Multi-effect composite treatment agent for body surfaces of livestock and poultry and application method of multi-effect composite treatment agent

Abstract

The invention relates to the technical field of livestock and poultry breeding, in particular to a livestock and poultry body surface multi-effect composite treatment agent and an application method thereof. 10 parts of glutaraldehyde; 7 to 8 parts of benzalkonium chloride; 3 to 4 parts of amitraz missible oil; 1 part of dexamethasone; and 15 to 20 parts of cross-linked glucan. According to the cross-linked dextran, dextran molecular chains are connected through a chemical cross-linking agent (epichlorohydrin) to form a three-dimensional network structure, so that drugs can be attached to the cross-linked dextran, the effect of controlling sustained release of the drugs is achieved, damage to the body surfaces of livestock and poultry caused by a large dose is avoided, and the drug delivery efficiency is improved. The anti-inflammatory effect of the treating agent on the body surface of the sick pig is obviously better than that of a traditional disinfectant, meanwhile, the collagen deposition variable of the corium layer of the body surface of the sick pig using the treating agent is smaller than that of the sick pig using the traditional disinfectant, that is, the stimulation of the treating agent on the body surface of the sick pig is smaller than that of the traditional disinfectant, and the treating agent is suitable for the sick pig. And the skin wilt is not easily caused.

Description

Technical Field

[0001] The invention relates to the technical field of animal and poultry breeding, and in particular to a multi-effect composite treatment agent for the surface of animal and poultry and an application method thereof. Background Art

[0002] Livestock and poultry are important sources of protein for residents. In order to increase their production, they are often raised in large-scale farms. Compared with ordinary free-range farming, they have greater advantages in terms of livestock and poultry excrement treatment, environmental pollution treatment, and management costs. In order to improve the resistance of livestock and poultry in farms and reduce the occurrence and spread of infectious diseases, it is necessary to administer necessary drugs while feeding.

[0003] However, the efficacy of traditional disinfectants evaporates quickly, and sick pigs need to be sprayed in small quantities and multiple times, which consumes a lot of labor. At the same time, traditional disinfectants are highly irritating to the skin and can easily cause skin atrophy. For this reason, we propose a multi-effect composite treatment agent for livestock and poultry surfaces and its application method to solve the above problems. Summary of the invention

[0004] The purpose of the present invention is to provide a multi-effect composite treatment agent for livestock and poultry body surfaces and an application method thereof, so as to solve the problems raised in the above-mentioned background technology.

[0005] To achieve the above object, the present invention provides the following technical solution: a multi-effect composite treatment agent for livestock and poultry body surface, comprising the following components:

[0006] 50 parts of purified water;

[0007] Glutaraldehyde 10 parts;

[0008] Benzalkonium chloride 7-8 parts;

[0009] 3-4 parts of amitraz emulsifiable concentrate;

[0010] Dexamethasone 1 part;

[0011] 15-20 parts of cross-linked polysaccharide.

[0012] Further preferably, the purified water is the solvent matrix, the glutaraldehyde has the effect of a disinfection enhancer, the benzalkonium chloride has the effect of a cationic disinfectant, the amitraz emulsifiable concentrate has the effect of a neurotoxic acaricide, and the dexamethasone has the effect of a precise anti-inflammatory agent.

[0013] Further preferably, the cross-linked dextran is mainly made of glucose through chemical reaction. Dextran is a high molecular weight polysaccharide formed by glucose units connected by α-1,6-glycosidic bonds. The cross-linked dextran is formed by connecting the dextran molecular chains through a chemical cross-linking agent (epichlorohydrin) to form a three-dimensional network structure, so that drugs can be attached thereto, thereby achieving the effect of controlling the sustained release of drugs and avoiding damage to the body surface of livestock and poultry due to large doses of drugs.

[0014] Further preferably, the method comprises the following steps:

[0015] S1: precooling the treatment agent to 15°C, using 40kHz ultrasonic dispersion to ensure that benzalkonium chloride, glutaraldehyde, amitraz, dexamethasone and cross-linked dextran are fully mixed and the dynamic viscosity reaches 2.5-3.0mPa·s;

[0016] S2: loading the treatment agent into a drug spraying machine;

[0017] S3: Adjust the parameters of the sprayer to make the spray pressure: 0.3MPa; droplet size: 50-80μm; coverage density: 0.25L / m 2 ;

[0018] S4: Spray the body surface of sick pigs evenly, twice a day in the morning and evening, for 3 consecutive days as a course of treatment.

[0019] Compared with the prior art, the beneficial effects of the present invention are as follows: the cross-linked dextran of the present invention is mainly made of glucose through chemical reaction. Dextran is a high molecular weight polysaccharide formed by connecting glucose units through α-1,6-glycosidic bonds. The cross-linked dextran is formed by connecting dextran molecular chains through a chemical cross-linking agent (epichlorohydrin) to form a three-dimensional network structure, so that drugs can be attached thereto, thereby achieving the effect of controlling the sustained release of drugs and avoiding damage to the body surface of livestock and poultry due to a large amount of drugs. The anti-inflammatory effect of the treatment agent on the body surface of sick pigs is significantly better than that of traditional disinfectants. At the same time, the collagen deposition variable of the dermis layer on the body surface of sick pigs using the treatment agent is smaller than that of sick pigs using traditional disinfectants, that is, the stimulation of the treatment agent on the body surface of sick pigs is relatively smaller than that of traditional disinfectants, and it is not easy to cause skin atrophy. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] Example

[0022] The present invention provides a technical solution: a multi-effect composite treatment agent for the surface of livestock and poultry, which is composed of the following components:

[0023] 50 parts of purified water;

[0024] Glutaraldehyde 10 parts;

[0025] Benzalkonium chloride 7-8 parts;

[0026] 3-4 parts of amitraz emulsifiable concentrate;

[0027] Dexamethasone 1 part;

[0028] 15-20 parts of cross-linked polysaccharide.

[0029] In this embodiment, specifically: purified water is the solvent matrix, glutaraldehyde acts as a disinfectant synergist, benzalkonium chloride acts as a cationic disinfectant, amitraz emulsifiable concentrate acts as a neurotoxic acaricide, and dexamethasone acts as a precise anti-inflammatory agent;

[0030] The C12-C14 alkyl chain of benzalkonium chloride forms a Schiff base structure with the aldehyde group of glutaraldehyde, which enhances the stability of the system; dexamethasone promotes the secretion of antimicrobial peptide (β-defensin) through positive feedback regulation;

[0031] In this embodiment, specifically: cross-linked dextran is mainly made of glucose through chemical reaction. Dextran is a high molecular weight polysaccharide formed by glucose units connected by α-1,6-glycosidic bonds. Cross-linked dextran is formed by connecting dextran molecular chains through chemical cross-linking agents (epichlorohydrin) to form a three-dimensional network structure, so that drugs can be attached thereto, thereby achieving the effect of controlling the sustained release of drugs and avoiding damage to the body surface of livestock and poultry caused by a large amount of drugs;

[0032] In this embodiment, specifically, the following steps are included:

[0033] S1: precool the treatment agent to 15°C, use 40kHz ultrasonic dispersion to ensure that benzalkonium chloride, glutaraldehyde, amitraz, dexamethasone and cross-linked dextran are fully mixed and the dynamic viscosity reaches 2.5-3.0mPa·s;

[0034] S2: Loading the treatment agent into the drug spraying machine;

[0035] S3: Adjust the parameters of the sprayer to make the spray pressure: 0.3MPa; droplet size: 50-80μm; coverage density: 0.25L / m 2 ;

[0036] S4: Spray the body surface of sick pigs evenly, twice a day in the morning and evening, for 3 consecutive days as a course of treatment.

[0037] Experimental verification

[0038] Experimental Group

[0039] 10 fattening pigs (weight 60-80kg) suffering from scabies and eczema were selected, and the treatment agent was used to treat the body surface of the sick pigs. A three-day course of treatment was sprayed once in the morning and evening every day. The inflammatory factor (IL-6) on the surface of the affected area and the amount of collagen deposition in the dermis were measured 30 minutes after the medication, and the following table was obtained:

[0040]

[0041] Control group

[0042] Ten fattening pigs (weight 60-80kg) suffering from scabies and eczema were selected, and traditional disinfectants were used to treat the body surface of the sick pigs. A three-day course of treatment was sprayed once in the morning and evening every day. The inflammatory factor (IL-6) on the surface of the affected area and the amount of collagen deposition in the dermis were measured 30 minutes after medication, and the records were obtained as follows:

[0043]

[0044] By comparing the data in the two tables, it can be learned that the anti-inflammatory effect of the treatment agent on the body surface of sick pigs is significantly better than that of traditional disinfectants. At the same time, the collagen deposition variable in the dermis of the sick pigs using the treatment agent is smaller than that of the sick pigs using traditional disinfectants. That is, the stimulation of the treatment agent on the body surface of sick pigs is smaller than that of traditional disinfectants, and it is not easy to cause skin atrophy.

[0045] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A multi-effect composite treatment agent for livestock and poultry body surface, characterized in that , consists of the following components, including: 50 parts of purified water; Glutaraldehyde 10 parts; Benzalkonium chloride 7-8 parts; 3-4 parts of amitraz emulsifiable concentrate; Dexamethasone 1 part; 15-20 parts of cross-linked polysaccharide.

2. The livestock and poultry body surface multi-effect composite treatment agent and its application method according to claim 1, characterized in that: The purified water is a solvent matrix, the glutaraldehyde acts as a disinfectant enhancer, the benzalkonium chloride acts as a cationic disinfectant, the amitraz emulsifiable concentrate acts as a neurotoxic acaricide, and the dexamethasone acts as a precise anti-inflammatory agent.

3. The multi-effect composite treatment agent for livestock and poultry body surface according to claim 2, characterized in that: The cross-linked dextran is mainly made of glucose through chemical reactions. Dextran is a high molecular weight polysaccharide formed by glucose units connected by α-1,6-glycosidic bonds. The cross-linked dextran is formed by connecting dextran molecular chains through a chemical cross-linking agent (epichlorohydrin) to form a three-dimensional network structure, so that drugs can be attached thereto, thereby achieving the effect of controlling the sustained release of drugs and avoiding damage to the body surface of livestock and poultry caused by large doses of drugs.

4. The application method of the livestock and poultry body surface multi-effect composite treatment agent according to claim 3, characterized in that: The steps include: S1: precooling the treatment agent to 15°C, using 40kHz ultrasonic dispersion to ensure that benzalkonium chloride, glutaraldehyde, amitraz, dexamethasone and cross-linked dextran are fully mixed and the dynamic viscosity reaches 2.5-3.0mPa·s; S2: loading the treatment agent into a drug spraying machine; S3: Adjust the parameters of the sprayer to make the spray pressure: 0.3MPa; droplet size: 50-80μm; coverage density: 0.25L / m 2 ; S4: Spray the body surface of sick pigs evenly, twice a day in the morning and evening, for 3 consecutive days as a course of treatment.

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