Traditional Chinese medicine oral tablet for treating urinary system lithiasis of dogs and cats

Abstract

The invention provides a traditional Chinese medicine oral tablet for treating urinary system lithiasis of dogs and cats, and relates to the technical field of traditional Chinese medicine oral tablets. The traditional Chinese medicine oral tablet for treating urinary system lithiasis of dogs and cats specifically comprises the following steps: S1, raw material treatment; s2, mixing and granulating; s3, drying and tabletting; and S4, coating treatment. A tablet coating material is prepared by extracting flavor substances from natural chicken liver powder, medicine components are wrapped in a chicken liver flavor layer, the bitter taste of the medicine is covered, it is ensured that pets are pleasant to eat, meanwhile, texture optimization is conducted, the tablet is crisp in texture, easy to chew and convenient to swallow, and food refusal caused by the fact that the tablet is too hard or too soft is avoided.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine oral tablets, in particular to a Chinese medicine oral tablet for treating urinary calculi in dogs and cats. Background Art

[0002] As people's living standards improve, keeping pets has become a new way of life. In recent years, the number of pet dogs and cats has increased year by year across the country. Keeping dogs and cats indoors in the home will restrict the cat's exercise and diet to a certain extent, and some diseases will follow. Stone disease in dogs and cats is one of the most common diseases that troubles owners and veterinarians.

[0003] Traditional treatment options are mostly surgical stone removal, which not only poses risks to the health of dogs and cats, but also costs a lot, causing certain financial pressure on pet owners. Secondly, surgical stone removal may not completely remove the stones, and it is easy to relapse. There are some types of drugs on the market that claim to be able to treat canine and cat stone disease, but most of them are Western medicines for diuretics and anti-inflammatory, with large side effects. Some also add Chinese medicine ingredients, but most of them are powders, which are not convenient to feed to dogs and cats. Therefore, there is an urgent need for a Chinese medicine tablet that can be used safely for a long time and is easy to feed to treat such diseases. Summary of the invention

[0004] In view of the deficiencies of the prior art, the present invention provides a Chinese medicine oral tablet for treating urinary calculi in dogs and cats, which solves the problem that it is inconvenient to feed dogs and cats in the prior art.

[0005] To achieve the above objectives, the present invention is implemented by the following technical scheme: a Chinese medicine oral tablet for treating urinary calculi in dogs and cats, specifically comprising the following steps:

[0006] S1. Raw material processing

[0007] Selecting Rhizoma Alismatis, Herba Lysimachiae, Herba Lygodii, and Gizzardii Gallifoliae, removing impurities and moldy parts, drying the herbs to a moisture content of ≤8%, and crushing them into 80-mesh fine powders. Using an airflow mill to crush the fine powders at nanometer level, the supersonic airflow speed is 300-500m / s, and the particles after crushing are graded and separated, the coarse particles are returned to the crushing area, and the fine particles are collected for standby use;

[0008] S2. Mixing and granulation

[0009] Weigh 85kg of nano-grade Chinese medicine powder (30kg of Rhizoma Alismatis, 25kg of Herba Lygodii, 15kg of Herba Lygodii, 15kg of Herba Galliformis Gizzardii) according to the mass ratio, add 4kg of sodium carboxymethyl starch, 1kg of magnesium stearate, 2kg of hydroxypropyl methylcellulose, and 3kg of talcum powder, mix until the color is uniform, add purified water to make a soft material, granulate with a swing granulator, and pass through a 14-mesh sieve;

[0010] S3. Drying and tableting

[0011] The wet granules were dried at 60°C until the moisture content was ≤5%, and then granulated into tablets with a tablet weight of 0.3 g / tablet;

[0012] S4. Coating treatment

[0013] Preparation of coating solution:

[0014] 2kg of polyvinyl alcohol, 1kg of polyethylene glycol and 2kg of chicken liver powder are dissolved in 45kg of 99% ethanol, filtered and sprayed on the surface of tablets preheated to 40-50°C, and multi-layer coating is applied to increase the weight by 5%. After coating, the tablets are polished and cured at 40-50°C, and the surface of the tablets is smooth and has a chicken liver flavor.

[0015] Preferably, in the nano-scale pulverization step, the particle size is 100-500 nm, the classification zone adopts centrifugal separation, and the fine particle collection efficiency is ≥95%.

[0016] Preferably, when the coating liquid is sprayed, hot air at 50-60° C. is introduced simultaneously, the rotation speed of the coating pan is 10-20 rpm, and the spraying speed and the drying speed are dynamically balanced.

[0017] Preferably, the tablets are prepared using enteric coating technology, and the coating layer dissolves in an intestinal environment with a pH of ≥6.8 to achieve targeted release.

[0018] Preferably, the chicken liver powder is prepared by cooking, freeze-drying and grinding fresh chicken liver, and the particle size is ≤100 mesh.

[0019] Preferably, the tablet hardness is 4-6 kg / cm 2 , friability ≤0.8%, the active feeding rate of dogs and cats in the palatability test is ≥90%, the tablet takes effect 2-4 hours after taking the medicine, the bioavailability is ≥85%, the treatment course is 7-14 days, and the stone dissolution rate is ≥80%.

[0020] Preferably, the tablets are independently packaged in aluminum-plastic blisters with three specifications of 0.3g / tablet, 0.5g / tablet and 1.0g / tablet, and the packaging humidity is ≤30%RH.

[0021] Preferably, in the formula, the mass ratio of Gallus gallus domesticus to Lygodium japonicum is 1:1, and the mass ratio of sodium carboxymethyl starch to hydroxypropyl methylcellulose is 2:1.

[0022] The present invention provides a Chinese medicine oral tablet for treating urinary calculi in dogs and cats. It has the following beneficial effects:

[0023] The invention provides a Chinese medicine oral tablet for treating urinary system calculi of dogs and cats. The technology crushes drug components to nanometer level through nanometer crushing, significantly increases the surface area of ​​the drug, improves the solubility and absorption rate, and enhances the efficacy. Enteric coating technology is adopted to accurately release the drug in the intestine, reduce the damage of gastric acid to the drug, improve bioavailability, optimize the drug formula, promote rapid absorption of the drug, shorten the onset time, and relieve the symptoms of pets more quickly. The drug components are scientifically proportioned, drug interactions are avoided, and the risk of side effects is reduced. Each tablet is independently packaged for easy carrying and storage, and is prevented from being damp and deteriorated. Tablets of different specifications are provided to meet the needs of pets of different sizes. The tablets are of moderate size, which is convenient for owners to directly feed or mix into food, simplifying the feeding process. Flavor substances are extracted from natural chicken liver powder to make tablet coating materials, and the drug components are wrapped in a chicken liver flavor layer to cover up the bitter taste of the drug, ensuring that the pet is willing to eat it. At the same time, the texture is optimized to make the tablets crisp and easy to chew, so that the pets can swallow them conveniently and avoid refusal to eat due to tablets being too hard or too soft. DETAILED DESCRIPTION

[0024] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] The embodiment of the present invention provides a Chinese medicine oral tablet for treating urinary calculi in dogs and cats, which specifically comprises the following steps:

[0026] S1. Raw material processing

[0027] Selecting Rhizoma Alismatis, Herba Lysimachiae, Herba Lygodii, and Gizzardii Gallifoliae, removing impurities and moldy parts, drying the herbs to a moisture content of ≤8%, and crushing them into 80-mesh fine powders. Using an airflow mill to crush the fine powders at nanometer level, the supersonic airflow speed is 300-500m / s, and the particles after crushing are graded and separated, the coarse particles are returned to the crushing area, and the fine particles are collected for standby use;

[0028] S2. Mixing and granulation

[0029] Weigh 85kg of nano-grade Chinese medicine powder (30kg of Rhizoma Alismatis, 25kg of Herba Lygodii, 15kg of Herba Lygodii, 15kg of Herba Galliformis Gizzardii) according to the mass ratio, add 4kg of sodium carboxymethyl starch, 1kg of magnesium stearate, 2kg of hydroxypropyl methylcellulose, and 3kg of talcum powder, mix until the color is uniform, add purified water to make a soft material, granulate with a swing granulator, and pass through a 14-mesh sieve;

[0030] S3. Drying and tableting

[0031] The wet granules were dried at 60°C until the moisture content was ≤5%, and then granulated into tablets with a tablet weight of 0.3 g / tablet;

[0032] S4. Coating treatment

[0033] Preparation of coating solution:

[0034] 2kg of polyvinyl alcohol, 1kg of polyethylene glycol and 2kg of chicken liver powder are dissolved in 45kg of 99% ethanol, filtered and sprayed on the surface of tablets preheated to 40-50°C, and multi-layer coating is applied to increase the weight by 5%. After coating, the tablets are polished and cured at 40-50°C, and the surface of the tablets is smooth and has a chicken liver flavor.

[0035] In the nano-scale crushing step, the particle size is 100-500nm, the classification zone is separated by centrifugal force, and the fine particle collection efficiency is ≥95%. When spraying the coating liquid, 50-60℃ hot air is introduced simultaneously, the coating pan speed is 10-20rpm, and the spray speed and drying speed are dynamically balanced. The tablets use enteric coating technology, and the coating layer dissolves in the intestinal environment of pH ≥ 6.8 to achieve targeted release. Chicken liver powder is made from fresh chicken liver by cooking, freeze-drying and grinding, with a particle size of ≤100 mesh. The tablet hardness is 4-6kg / cm 2 , friability ≤0.8%, active feeding rate of dogs and cats in palatability test ≥90%, tablets take effect 2-4 hours after taking the medicine, bioavailability ≥85%, treatment course 7-14 days, stone dissolution rate ≥80%. The tablets are individually packaged in aluminum-plastic blisters, with specifications of 0.3g / tablet, 0.5g / tablet, and 1.0g / tablet, and packaging humidity ≤30%RH. The mass ratio of chicken gizzard lining to sea sand in the formula is 1:1, and the mass ratio of sodium carboxymethyl starch to hydroxypropyl methylcellulose is 2:1.

[0036]

[0037]

[0038] Table 1: Palatability comparison experiment (n=50 dogs and cats)

[0039] Test indicators Tablets of this technology Ordinary Chinese medicine tablets Test Method Active feeding rate 92％ 35％ Double basin free choice method (24 hours) Average feeding time 8.7 seconds Unfinished Infrared sensor timing system Residual drug amount 0.05g / tablet 0.82g / tablet Precision weighing method

[0040] Table 2: In vitro dissolution test (simulated intestinal fluid)

[0041]

[0042] Table 3: Clinical effect verification (canine urinary stones case)

[0043]

[0044]

[0045] Table 4: Stability test (25℃ / RH60%)

[0046]

[0047] The technology of the present invention improves the solubility and absorption rate of the drug through nano-scale crushing, enhances the efficacy, and uses enteric coating technology to accurately release the drug in the intestine, reduce gastric acid damage, and improve bioavailability. Optimize the drug formula to promote rapid absorption, shorten the onset time, and relieve pet symptoms. Strictly select high-quality raw materials and use a fully automated production line to ensure product safety and reliability. Independent packaging is convenient for carrying and storage, and a variety of specifications are provided to meet the needs of different pets. The tablets are moderately sized and easy to feed, simplifying the feeding process. The bitter taste of the drug is covered by chicken liver flavor coating to ensure that pets are happy to eat it, and the texture is crispy and easy to chew to avoid refusal to eat.

[0048] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine oral tablet for treating urinary calculi in dogs and cats, characterized in that: The specific steps include: S1. Raw material processing Selecting Rhizoma Alismatis, Herba Lysimachiae, Herba Lygodii, and Gizzardii Gallifoliae, removing impurities and moldy parts, drying the herbs to a moisture content of ≤8%, and crushing them into 80-mesh fine powders. Using an airflow mill to crush the fine powders at nanometer level, the supersonic airflow speed is 300-500m / s, and the particles after crushing are graded and separated, the coarse particles are returned to the crushing area, and the fine particles are collected for standby use; S2. Mixing and granulation Weigh 85kg of nano-grade Chinese medicine powder (30kg of Rhizoma Alismatis, 25kg of Herba Lygodii, 15kg of Herba Lygodii, 15kg of Herba Galliformis Gizzardii) according to the mass ratio, add 4kg of sodium carboxymethyl starch, 1kg of magnesium stearate, 2kg of hydroxypropyl methylcellulose, and 3kg of talcum powder, mix until the color is uniform, add purified water to make a soft material, granulate with a swing granulator, and pass through a 14-mesh sieve; S3. Drying and tableting The wet granules were dried at 60°C until the moisture content was ≤5%, and then granulated into tablets with a tablet weight of 0.3 g / tablet; S4. Coating treatment Preparation of coating solution: 2kg of polyvinyl alcohol, 1kg of polyethylene glycol and 2kg of chicken liver powder are dissolved in 45kg of 99% ethanol, filtered and sprayed on the surface of tablets preheated to 40-50°C, and multi-layer coating is applied to increase the weight by 5%. After coating, the tablets are polished and cured at 40-50°C, and the surface of the tablets is smooth and has a chicken liver flavor.

2. A Chinese medicine oral tablet for treating urinary calculi in dogs and cats according to claim 1, characterized in that: In the nano-scale pulverization step, the particle size is 100-500 nm, the classification zone adopts centrifugal separation, and the fine particle collection efficiency is ≥95%.

3. A Chinese medicine oral tablet for treating urinary calculi in dogs and cats according to claim 1, characterized in that: When the coating liquid is sprayed, hot air at 50-60° C. is introduced simultaneously, the rotation speed of the coating pan is 10-20 rpm, and the spraying speed and the drying speed are dynamically balanced.

4. A Chinese medicine oral tablet for treating urinary calculi in dogs and cats according to claim 1, characterized in that: The tablet adopts enteric coating technology, and the coating layer dissolves in the intestinal environment with a pH of ≥6.8 to achieve targeted release.

5. A Chinese medicine oral tablet for treating urinary calculi in dogs and cats according to claim 1, characterized in that: The chicken liver powder is prepared by boiling, freeze-drying and grinding fresh chicken liver, and the particle size is ≤100 meshes.

6. A Chinese medicine oral tablet for treating urinary calculi in dogs and cats according to claim 1, characterized in that: The tablet hardness is 4-6kg / cm 2 , friability ≤0.8%, the active feeding rate of dogs and cats in the palatability test is ≥90%, the tablet takes effect 2-4 hours after taking the medicine, the bioavailability is ≥85%, the treatment course is 7-14 days, and the stone dissolution rate is ≥80%.

7. A Chinese medicine oral tablet for treating urinary calculi in dogs and cats according to claim 1, characterized in that: The tablets are independently packaged in aluminum-plastic blisters with three specifications of 0.3 g / tablet, 0.5 g / tablet and 1.0 g / tablet, and the packaging humidity is ≤30% RH.

8. A Chinese medicine oral tablet for treating urinary calculi in dogs and cats according to claim 1, characterized in that: In the formula, the mass ratio of chicken's gizzard lining to Lygodium japonicum is 1:1, and the mass ratio of sodium carboxymethyl starch to hydroxypropyl methylcellulose is 2:1.

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