Pulsation simulation method and system based on blood pump

Abstract

The invention relates to a pulse simulation method and system based on a blood pump, and the method comprises the steps: firstly obtaining at least one heart indication signal, judging whether the heart indication signal is abnormal or not according to the heart indication signal, and adjusting the rotation speed of the blood pump according to the heart indication signal after the judgment result is normal. Compared with constant-flow perfusion, the flow and blood pressure which are more accordant with physiology can be provided, the pulse change of the heart cannot be resisted, the output power of the blood pump can be timely adjusted along with the change of the cardiac function of a patient, a better perfusion effect can be generated, and the thrombus risk is reduced; and compared with constant current, the damage to blood cells is not obviously changed. According to the application, abnormal conditions can be eliminated, the heart indication signal is accurately judged, and synchronous starting is performed according to the pressurization point and the depressurization point of ventricular contraction and expansion, so that accurate following shot is performed on heart pulsation. And moreover, the time required by a counterpulsation period is greatly shortened, and rapid pressurization and depressurization operation is realized.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a pulsation simulation method and system based on a blood pump. Background Art

[0002] In clinical scenarios, heart pulsation simulation is mainly used to improve cardiac hemodynamics and solve the problem of insufficient cardiac pumping capacity, such as left ventricular assist; at the same time, it provides temporary organ perfusion protection in scenarios such as organ transplantation.

[0003] Existing devices improve heart function through mechanical assistance, mainly through the periodic inflation and deflation of the balloon in the aorta, enhancing coronary perfusion and distal blood flow and reducing cardiac afterload, thereby buying treatment time for critically ill heart disease patients or transitioning to more advanced support methods.

[0004] Since traditional balloon counterpulsation relies on the inflation and deflation of the air bag to complete pressure regulation, the inflation based on this principle takes a certain amount of time to complete, so preparations need to be made before ventricular contraction, and the T wave needs to be found as the starting point for the inflation action. If the heart's T wave disappears or weakens due to abnormal conditions, such as hyperkalemia, ventricular fibrillation, etc., the action of the balloon counterpulsation will be affected, which may cause the pressurization point that should have been started synchronously during ventricular contraction to be missed due to incomplete inflation, resulting in a missed beat.

[0005] And because inflation causes the minimum cycle of each balloon counter-beat to be longer, when the heart rate rises, it will lead to a larger heartbeat-inflation ratio, which will reduce the ventricular assist capacity. At the same time, the maximum speed of deflation depends entirely on the physical properties of the balloon, and rapid blood pressure reduction may not be possible.

[0006] In summary, traditional balloon anti-pulsation has the following defects: 1. Sensitive to trigger signals. If the ECG signal (such as T wave, R wave) or aortic pressure waveform (such as dicrotic notch) is misidentified or abnormal, it may cause inflation and deflation to be too early or too late, weakening the auxiliary effect and even increasing the burden on the heart.

[0007] 2. The balloon inflation mechanism causes the preparation time and single action cycle to be too long, and it cannot effectively follow up after the heart rate rises, which increases the heartbeat-inflation ratio and weakens the auxiliary effect, that is, poor counterpulsation. Other reasons may also cause poor counterpulsation, such as severe left ventricular systolic dysfunction, a significant decrease in systemic vascular resistance, and a too small balloon.

[0008] 3. The adjustment of the slope of the pulsation curve is limited, mainly due to the physical properties of the balloon.

[0009] 4. The catheter needs to be introduced through the blood vessels. Leaving it in place for too long may cause local or systemic infection, and may also induce thrombosis. Summary of the invention

[0010] In order to solve the defects that abnormal conditions cause the disappearance or weakening of the heart T wave, resulting in the missed beat of the boost point that should have been started synchronously during ventricular contraction due to incomplete inflation, and the inflation causes the minimum cycle of each balloon counter-pulsation to be longer, which may make it impossible to reduce the pressure quickly when required, the present invention proposes a pulsation simulation method based on a blood pump.

[0011] The technical solution adopted by the present invention is a pulsation simulation method based on a blood pump, comprising: acquiring at least one cardiac indication signal; Determine whether the heart indication signal is abnormal; The blood pump adjusts its speed according to normal heart instructions.

[0012] In some embodiments, including: Acquiring electrocardiogram signals and / or intracardiac pressure signals; Determine whether the electrocardiogram signal and / or intracardiac pressure signal are abnormal; The blood pump adjusts its rotation speed according to normal electrocardiogram signals and / or intracardiac pressure signals.

[0013] In some embodiments, the step of adjusting the rotation speed of the blood pump according to the normal electrocardiogram signal and the intracardiac pressure signal includes: When the electrocardiogram signal reaches the apex of the R wave and / or the intracardiac pressure signal reaches the ventricular systolic phase, the blood pump performs pressurization, and the blood pump pressurization rate matches the intracardiac pressure change rate; When the electrocardiogram signal reaches the midpoint of the T wave and / or the intracardiac pressure signal reaches the ventricular diastole, the blood pump performs decompression, and the decompression rate of the blood pump matches the intracardiac pressure change rate.

[0014] In some embodiments, the step of adjusting the rotation speed of the blood pump according to the normal electrocardiogram signal and / or the intracardiac pressure signal includes: While the blood pump is adjusting its own rotation speed, the intracardiac pressure is monitored and the rotation speed is kept constant when the target value is reached.

[0015] In some embodiments, the step of acquiring an electrocardiogram signal and / or an intracardiac pressure signal includes: Acquire electrocardiogram signal and intracardiac pressure signal simultaneously; The electrocardiogram signal and the intracardiac pressure signal are mutually verified.

[0016] In some embodiments, the blood pump is a magnetically levitated blood pump.

[0017] In some embodiments, in the step of determining whether the cardiac indication signal is abnormal, if the cardiac indication signal is abnormal, the step includes: Determine the type of anomaly based on the anomaly database; The blood pumping pattern is regulated by abnormal species.

[0018] In some embodiments, in the step of adjusting the pumping mode of the blood pump by the abnormality category, the pumping mode includes at least one of a first pumping mode and a second pumping mode; The first pump-out mode performs pulsatile perfusion corresponding to the abnormal type; The second pump-out mode is to drive the intracardiac pressure in response to signal loss.

[0019] In order to solve the defects of the existing pulsation simulation system that the heart T wave disappears or weakens under abnormal conditions, resulting in the missed beat of the boost point that should be started synchronously during ventricular contraction due to incomplete inflation, and the long minimum cycle of each balloon counter-beat due to inflation, which may not be able to achieve rapid pressure reduction when required, the present invention proposes a pulsation simulation system based on a blood pump.

[0020] The technical solution adopted by the present invention is a pulsation simulation system based on a blood pump, comprising: A sensor module, for acquiring at least one cardiac indication signal; The control module is connected with the sensor module signal to determine whether the heart indication signal is abnormal; The blood pump is connected to the control module signal, and the blood pump adjusts its own rotation speed according to the normal heart indication signal.

[0021] In some embodiments, the sensing module includes an intracardiac pressure sensor and an electrocardiograph, and both the intracardiac pressure sensor and the electrocardiograph are signal-connected to the control module.

[0022] Compared with the prior art, the present invention has the following beneficial effects: The present application discloses a pulsation simulation method and system based on a blood pump. First, at least one heart indication signal for evaluating the heart pulsation state is obtained, and the heart indication signal is judged whether it is abnormal. After the judgment result is normal, the blood pump adjusts its own speed according to the heart indication signal. In this way, a more accurate pulsation flow can be obtained. Compared with constant flow perfusion, it can provide a more physiological flow and blood pressure, will not fight against the pulsation changes of the heart itself, and can adjust the blood pump output power in time with the changes in the patient's cardiac function. It can produce a better perfusion effect, reduce the risk of thrombosis, and the damage to blood cells is not significantly changed compared with the constant flow. Compared with the prior art, the pulsation simulation method and system based on a blood pump disclosed in the present application can eliminate abnormal situations, accurately judge the heart indication signal, and start synchronously according to the boost point and depressurization point of ventricular contraction and expansion, so as to accurately follow the heart pulsation. And it greatly reduces the time required for the counter-beat cycle, and realizes rapid boost and depressurization operations. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The present invention is described in detail below with reference to the embodiments and accompanying drawings, wherein: Figure 1 A schematic flow chart of a pulsation simulation method based on a blood pump provided in accordance with an embodiment of the present invention is shown; Figure 2 A schematic flow chart of a pulsation simulation method based on a blood pump according to another embodiment of the present invention is shown; Figure 3 A schematic diagram of a process of using only electrocardiogram signals in a pulsation simulation method based on a blood pump according to an embodiment of the present invention is shown; Figure 4 A schematic diagram of a flow chart of using only an intracardiac pressure signal in a pulsation simulation method based on a blood pump according to an embodiment of the present invention is shown; Figure 5 A module schematic diagram of a blood pump-based pulsation simulation system provided according to an embodiment of the present invention is shown. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical scheme and advantages of the present invention clearer, the embodiments of the present invention will be further described in detail below in conjunction with the accompanying drawings. Examples of embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar components or components with the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be interpreted as limiting the present invention.

[0025] The present invention discloses a pulsation simulation method based on a blood pump, please refer to Figures 1 to 4 ,include: acquiring at least one cardiac indication signal; Determine whether the heart indication signal is abnormal; The blood pump adjusts its speed according to normal heart instructions.

[0026] Among them, the heart indication signal refers to the electrocardiogram signal, intracardiac pressure signal, heart sound signal, cardiac blood flow output and other indication signals that can indicate the heart's pulsation state and stage. By analyzing the heart indication signal, the operator can obtain the heart's pulsation stage.

[0027] Specifically, the heart can be divided into several stages: atrial contraction (atrial depolarization), ventricular contraction (left and right ventricular depolarization), ventricular slow repolarization, ventricular rapid repolarization, and ventricular filling. The T wave is located in the area of ​​ventricular rapid repolarization, and ventricular diastole ends at the end of the T wave. The electrocardiogram signal can judge the heart pulsation stage by time and peaks and troughs. The specific electrocardiogram waveforms are P wave, PR segment, QRS complex, ST segment, T wave, and TP segment. The intracardiac pressure signal can reflect the heart load through the pressure, that is, systolic pressure / diastolic pressure. The heart sound signal can judge the heart pulsation stage through the vibration sound produced by blood flow and valve closure during heart contraction and diastole. The amount of blood pumped by the heart can judge the heart pulsation stage through the overall pumping efficiency.

[0028] Abnormal signals refer to the situation where, in some cases, some phases of the heart's pulsation are unclear or lost. For example, in cases of hyperkalemia or ventricular fibrillation, the heart's T wave disappears or weakens. At this time, it is necessary to judge such phenomena in order to provide accurate control information for the blood pump.

[0029] By using a blood pump to adjust the flow, a more precise pulsating flow can be obtained compared to constant flow perfusion, providing a more physiological flow and blood pressure, which will not conflict with the heart's own pulsating changes, can produce a better perfusion effect, reduce the risk of thrombosis, and has no significant change in the damage to blood cells compared to constant flow.

[0030] Among them, there is at least one heart indication signal. When there are multiple heart indication signals, different types of heart indication signals can be coordinated with each other and monitor the heart pulsation state from different dimensions, so as to obtain more real and reliable stage data. It is also possible to select the most appropriate one from multiple heart indication signals as an indicator for judging whether the heart indication signal is abnormal, and participate in the subsequent pumping flow adjustment process.

[0031] With multiple selectable heart indication signals, the blood pump speed adjustment can be more precise to meet more practical needs. For example, if the doctor or patient requires a staged large flow or high pressure effect, the upper limit of pressure or flow can be adjusted directly. The blood pump will automatically meet the changing needs during the pulsation process, reducing the damage to the human body caused by drug pressurization in the past. At the same time, as the patient's recovery level increases, the auxiliary demand for the blood pump will also decrease. At this time, the auxiliary capacity can also be reduced by adjusting the upper limit of pressure or flow.

[0032] This application does not limit the number of blood pumps. Series mode: When the pressure increase capacity of a single blood pump is insufficient, such as when the heart rate is too fast or it is used for large animals, multiple blood pumps can be connected in series. The relevant control method refers to the control method for a single blood pump. Parallel mode: When the flow rate of a single blood pump is insufficient, multiple blood pumps can be connected in parallel. The relevant control method refers to the control method for a single blood pump.

[0033] The present application also has a fixed mode: when used for perfusion of isolated organs, real-time biological information of the human body is no longer required, but simulated pulsating flow helps to supply and protect isolated organs, so the maximum / minimum perfusion pressure / flow can be set, and then the appropriate pulsating waveform can be selected to enable the device to increase or decrease pressure within a limited range, and the waveform change curvature can also be set.

[0034] The present application discloses a pulsation simulation method based on a blood pump. When the heart rate is too fast, a mixed pulsation of heartbeat and blood pump pulsation can be adopted, that is, a certain heartbeat-blood pump pulsation ratio is adopted.

[0035] In some embodiments, including: Acquiring electrocardiogram signals and / or intracardiac pressure signals; Determine whether the electrocardiogram signal and / or intracardiac pressure signal are abnormal; The blood pump adjusts its rotation speed according to normal electrocardiogram signals and / or intracardiac pressure signals.

[0036] Specifically, the heart indication signal is an electrocardiogram signal and / or an intracardiac pressure signal, which are the most intuitive for determining the heart state stage. In this embodiment, the heart indication signal can be an electrocardiogram signal, an intracardiac pressure signal, or both.

[0037] In some embodiments, the step of adjusting the rotation speed of the blood pump according to the normal electrocardiogram signal and the intracardiac pressure signal includes: When the electrocardiogram signal reaches the apex of the R wave and / or the intracardiac pressure signal reaches the ventricular systolic phase, the blood pump performs pressurization, and the blood pump pressurization rate matches the intracardiac pressure change rate; When the electrocardiogram signal reaches the midpoint of the T wave and / or the intracardiac pressure signal reaches the ventricular diastole, the blood pump performs decompression, and the decompression rate of the blood pump matches the intracardiac pressure change rate.

[0038] Among them, the apex of the R wave is located in the QRS complex, which corresponds to the ventricular contraction period, and at this time, the left and right ventricular depolarization process is also in progress. The T wave is the ventricular rapid repolarization stage, and the midpoint of the T wave corresponds to the midpoint position of the T wave, at which the ventricular diastole phase begins.

[0039] The electrocardiogram signal reaching the apex of the R wave and the intracardiac pressure signal reaching the ventricular contraction phase are respectively different expressions of the electrocardiogram signal and the intracardiac pressure signal when the heart pulse arrives at the same stage. When reaching this point, the blood pump is pressurized, and the present application specifically limits the matching of the pressurization rate of the blood pump and the rate of change of the intracardiac pressure, so as to perfectly match the pulsation state of the heart.

[0040] At the same time, please note that this point is the point where the pump boost takes effect, that is, the delay problem of the pump control signal is ignored; if the signal delay problem is considered, the boost signal input point can be set to the midpoint of the T wave + ∆t1, so that the starting point of the boost effect is the top of the R wave.

[0041] The electrocardiogram signal reaching the midpoint of the T wave and the intracardiac pressure signal reaching the ventricular diastole are different expressions of the electrocardiogram signal and the intracardiac pressure signal when the heart pulse arrives at the same stage. When reaching this point, the blood pump decompresses, and the present application specifically limits the matching of the decompression rate of the blood pump and the rate of change of the intracardiac pressure, so as to perfectly match the pulsation state of the heart.

[0042] At the same time, please note that this point is the point where the pump takes effect of reducing pressure, that is, the delay problem of the pump control signal is ignored; if the signal delay problem is considered, the pressure reduction signal input point can be set to the pressure increase signal input point + ∆t2, and this ∆t2 can be corrected as the collected electrocardiogram signal continues to increase, so that the pressure reduction starting point of the pump is the midpoint of the T wave.

[0043] In some embodiments, the step of adjusting the rotation speed of the blood pump according to the normal electrocardiogram signal and / or the intracardiac pressure signal includes: While the blood pump is adjusting its own rotation speed, the intracardiac pressure is monitored and the rotation speed is kept constant when the target value is reached.

[0044] It should be noted that when the intracardiac pressure reaches the target value, the blood pump speed can be kept constant to prevent the pressure increase or pressure reduction transition. That is, when the flow rate is increasing, when the detection reaches the target value, the speed increase is stopped to prevent the pressure increase transition; when the flow rate is decreasing, when the detection reaches the target value, the speed reduction is stopped to prevent the pressure reduction transition.

[0045] In some embodiments, please refer to Figure 2 In the step of the blood pump adjusting its own rotation speed according to the normal electrocardiogram signal and / or the intracardiac pressure signal, it includes: in the process of the blood pump adjusting its own rotation speed, the flow rate pumped by the blood pump is monitored, and when the target value is reached, the blood pump maintains a constant rotation speed.

[0046] In some embodiments, the step of acquiring an electrocardiogram signal and / or an intracardiac pressure signal includes: Acquire electrocardiogram signal and intracardiac pressure signal simultaneously; The electrocardiogram signal and the intracardiac pressure signal are mutually verified.

[0047] Specifically, after simultaneously acquiring the electrocardiogram signal and the intracardiac pressure signal, the two need to be verified against each other to determine the authenticity of the signals. In theory, both will simultaneously receive signals indicating changes in the phase of the heart pulse. If the signals are not generated at the same time in the same phase, it means that an error has occurred in the acquisition of the signal, and they need to be checked and corrected and verified against each other before the subsequent steps can be carried out.

[0048] In some embodiments, the blood pump is a magnetically levitated blood pump.

[0049] Using a magnetically levitated blood pump has the following advantages: The impeller driven by magnetic levitation technology can quickly meet the target pressure requirements through speed changes, and eliminates problems such as long pulsation cycle or missed beats caused by no preparatory action; The slope of the pulsation curve of the magnetically suspended blood pump can be precisely controlled to balance hemodynamics with cell damage such as hemolysis; The frictionless characteristics of the impeller can achieve less damage to biological cells and blood compared to blood pumps with single-point bearings, and are more adaptable to pulsating conditions.

[0050] In some embodiments, in the step of determining whether the cardiac indication signal is abnormal, if the cardiac indication signal is abnormal, the step includes: Determine the type of anomaly based on the anomaly database; The blood pumping pattern is regulated by abnormal species.

[0051] Among them, the abnormal database stores abnormal signals of different types of heart indication signals and the corresponding abnormal types. After receiving the abnormal signal, the type of the heart indication signal can be judged through the abnormal database. After judging the type, the heart indication signal is similarly matched to determine what kind of abnormal signal it is and obtain the corresponding abnormal type.

[0052] It should be noted that the method for judging whether the heart indication signal is abnormal can be a key threshold judgment method, that is, when it exceeds or is lower than the threshold range at a certain key position, the heart indication signal is judged to be abnormal; it can also be a priori data fitting method, that is, fitting the obtained heart indication signal with the prior normal heart indication signal to judge whether it meets the requirements.

[0053] In some embodiments, in the step of adjusting the pumping mode of the blood pump by the abnormality category, the pumping mode includes at least one of a first pumping mode and a second pumping mode; The first pump-out mode performs pulsatile perfusion corresponding to the abnormal type; The second pump-out mode is to drive the intracardiac pressure in response to signal loss.

[0054] When the ECG waveform is abnormal, a specific pulsation can be output according to the abnormal ECG waveform. Pulsating perfusion is blood delivery in a non-constant flow mode, and the flow rate changes in the form of a pulsating curve. When the ECG signal is lost, the intracardiac pressure drive mode can be started. The intracardiac pressure drive is to adjust the flow of the blood pump based on the intracardiac pressure signal.

[0055] In order to solve the defects of the existing pulsation simulation system that the heart T wave disappears or weakens under abnormal conditions, resulting in the missed beat of the boost point that should be started synchronously during ventricular contraction due to incomplete inflation, and the long minimum cycle of each balloon counter-beat due to inflation, which may not be able to achieve rapid pressure reduction when required, the present invention proposes a pulsation simulation system based on a blood pump.

[0056] The technical solution adopted by the present invention is, please refer to Figure 5 , a pulsation simulation system based on a blood pump, comprising: A sensor module, for acquiring at least one cardiac indication signal; The control module is connected with the sensor module signal to determine whether the heart indication signal is abnormal; The blood pump is connected to the control module signal, and the blood pump adjusts its own rotation speed according to the normal heart indication signal.

[0057] In some embodiments, the sensing module includes an intracardiac pressure sensor and an electrocardiograph, and both the intracardiac pressure sensor and the electrocardiograph are signal-connected to the control module.

[0058] In the description of this specification, if the terms "embodiment one", "this embodiment", "in an embodiment" and the like appear, it means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in the invention or at least one embodiment or example of the invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example; moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in an appropriate manner.

[0059] In the description of this specification, the terms "connect", "install", "fix", "set", "have", etc. are all understood in a broad sense. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0060] In the description of this specification, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "comprises", "comprising" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the statement "comprising a ..." does not exclude the presence of other identical elements in the process, method, article or device including the element.

[0061] The above description of the embodiments is to facilitate ordinary technicians in the technical field to understand and apply the technology of this case. People familiar with the technology in this field can obviously easily make various modifications to these examples and apply the general principles described here to other embodiments without creative work. Therefore, this case is not limited to the above embodiments. Modifications to the following situations should all be within the scope of protection of this case: ① A new technical solution implemented based on the technical solution of the present invention and combined with existing common knowledge, the technical effect produced by the new technical solution does not exceed the technical effect of the present invention; ② The equivalent replacement of some features of the technical solution of the present invention by using known technology, the technical effect produced is the same as the technical effect of the present invention; ③ The technical solution of the present invention can be expanded, and the substantive content of the expanded technical solution does not exceed the technical solution of the present invention; ④ The equivalent transformation made by using the contents of the description and drawings of the present invention is directly or indirectly applied to other related technical fields.

Claims

1. A pulsation simulation method based on a blood pump, characterized in that: include: acquiring at least one cardiac indication signal; determining whether the heart indication signal is abnormal; The blood pump adjusts its own rotation speed according to the normal heart indication signal.

2. A pulsation simulation method based on a blood pump according to claim 1, characterized in that: include: Acquiring electrocardiogram signals and / or intracardiac pressure signals; Determining whether the electrocardiogram signal and / or the intracardiac pressure signal are abnormal; The blood pump adjusts its own rotation speed according to the normal electrocardiogram signal and / or the intracardiac pressure signal.

3. A pulsation simulation method based on a blood pump according to claim 2, characterized in that: The step of adjusting the rotation speed of the blood pump according to the normal electrocardiogram signal and the intracardiac pressure signal includes: When the electrocardiogram signal reaches the apex of the R wave and / or the intracardiac pressure signal reaches the ventricular systole, the blood pump performs pressurization, and the pressurization rate of the blood pump matches the rate of change of the intracardiac pressure; When the electrocardiogram signal reaches the midpoint of the T wave and / or the intracardiac pressure signal reaches the ventricular diastole, the blood pump performs decompression, and the decompression rate of the blood pump matches the intracardiac pressure change rate.

4. A pulsation simulation method based on a blood pump according to claim 2, characterized in that: The step of adjusting the blood pump's rotation speed according to the normal electrocardiogram signal and / or the intracardiac pressure signal includes: When the blood pump adjusts its own rotation speed, the size of the intracardiac pressure is monitored, and the rotation speed is kept constant when the target value is reached.

5. A pulsation simulation method based on a blood pump according to claim 2, characterized in that: The step of acquiring an electrocardiogram signal and / or an intracardiac pressure signal includes: Acquire the electrocardiogram signal and the intracardiac pressure signal simultaneously; The electrocardiogram signal and the intracardiac pressure signal are mutually verified.

6. A pulsation simulation method based on a blood pump according to any one of claims 1 to 5, characterized in that: The blood pump is a magnetically suspended blood pump.

7. A pulsation simulation method based on a blood pump according to any one of claims 1 to 5, characterized in that: In the step of determining whether the heart indication signal is abnormal, if the heart indication signal is abnormal, it includes: Determine the type of anomaly based on the anomaly database; The pumping pattern of the blood pump is adjusted according to the abnormality type.

8. A pulsation simulation method based on a blood pump according to claim 7, characterized in that: In the step of adjusting a pumping mode of the blood pump according to the abnormality category, the pumping mode includes at least one of a first pumping mode and a second pumping mode; The first pumping mode performs corresponding pulsatile perfusion according to the abnormal type; The second pumping mode performs intracardiac pressure driving in response to signal loss.

9. A pulsation simulation system based on a blood pump, characterized in that: include: A sensor module, for acquiring at least one cardiac indication signal; A control module, connected to the sensor module signal, to determine whether the heart indication signal is abnormal; The blood pump is connected to the control module signal, and the blood pump adjusts its own rotation speed according to the normal heart indication signal.

10. A pulsation simulation system based on a blood pump according to claim 9, characterized in that: The sensing module includes an intracardiac pressure sensor and an electrocardiograph, and both the intracardiac pressure sensor and the electrocardiograph are signal-connected to the control module.

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