Bronchoscope simulation training device based on pig in-vitro lung tissue

Abstract

The invention belongs to the technical field of bronchoscope simulation training, and discloses a bronchoscope simulation training device based on pig in-vitro lung tissue, which comprises a sealing module, a trachea connecting module, a negative pressure control module, a liquid simulation module and an observation module, continuous expansion of the in-vitro lung tissue airway is achieved for the first time through the negative pressure technology, the anatomical structure under a bronchoscope is extremely close to the actual clinical environment, and the training authenticity is remarkably improved. The in-vitro pig lung tissue blood circulation state is simulated through an external liquid circulation system, and the training effects of ultrasonic image recognition, blood vessel positioning and puncture skills are greatly enhanced in EBUS technical training. Due to the sealing design of the box body and environment control (temperature, humidity and negative pressure), the activity maintaining time of lung tissue is obviously prolonged (more than several hours), the training benefit is improved, and the training cost is reduced. The operation process is transparent and visible, real-time observation is achieved, and the possibility is provided for accurately evaluating the training effect.

Description

Technical Field

[0001] The invention belongs to the technical field of bronchoscopic simulation training, and in particular relates to a bronchoscopic simulation training device based on isolated pig lung tissue. Background Art

[0002] Prior art: Common isolated animal organs (such as isolated pig lungs) simulation training device

[0003] The most commonly used bronchoscopy training method in the prior art is to directly use static ex vivo animal tissue. This type of prior art has the following technical problems that need to be solved urgently: the alveolar closure state of ex vivo lung tissue is difficult to truly restore the airway structure, and the simulation effect is poor. The lack of a real circulatory system makes it difficult to simulate the activity state of blood vessels and tissues, and it is impossible to truly reflect the imaging characteristics under EBUS ultrasound. The lack of means to maintain the expansion state of lung tissue causes the airway to gradually shrink during training, and it is impossible to maintain a good training state continuously.

[0004] Through the above analysis, the problems and defects of the prior art are as follows:

[0005] (1) The alveolar closure state of isolated lung tissue is difficult to truly restore the airway structure, and the simulation effect is poor.

[0006] (2) The lack of a real circulatory system makes it difficult to simulate the activity of blood vessels and tissues and cannot truly reflect the imaging characteristics under EBUS ultrasound.

[0007] (3) The lack of means to maintain the expanded state of lung tissue causes the airway to gradually shrink during training, making it impossible to maintain a good training state. Summary of the invention

[0008] In view of the problems existing in the prior art, the present invention provides a bronchoscopic simulation training device based on isolated pig lung tissue.

[0009] The present invention is implemented in this way: a bronchoscopic simulation training device based on isolated pig lung tissue comprises:

[0010] Sealing module, trachea connection module, negative pressure control module, liquid simulation module, observation module;

[0011] The sealing module is connected with the trachea connection module, the negative pressure control module, the liquid simulation module and the observation module, and is used to provide a sealing cover on the sealing box body, and a silicone sealing ring is provided between the sealing cover and the box body;

[0012] The trachea connection module is connected to the sealing module and is arranged at the central position of the sealing cover of the box body through the trachea connection port structure; a silicone sealing ring and a medical clamping device are arranged on the interface to ensure the sealing between the lung trachea and the interface;

[0013] The negative pressure control module is connected to the sealing module and is used to accurately control the negative pressure through the negative pressure control system to ensure the stable state of the airway during training;

[0014] A liquid simulation module, connected to the sealing module, for recycling and stabilizing the circulation of the circulating liquid through the circulating liquid simulation system;

[0015] The observation module is connected to the sealing module and is used to observe the expansion of pig lung tissue, the training process and the bronchoscope path in real time.

[0016] Furthermore, the sealing module:

[0017] Sealed box structure material and specifications:

[0018] Made of medical grade transparent plexiglass or polycarbonate material;

[0019] The box size is generally about 50cm long × 40cm wide × 35cm high;

[0020] A sealing cover is provided on the box body, and a silicone sealing ring is provided between the sealing cover and the box body;

[0021] A special observation window is provided on the side wall or the rear wall.

[0022] Furthermore, the trachea connection module:

[0023] Trachea connection port structure:

[0024] Set at the center of the box sealing cover;

[0025] The diameter of the connection port is about 23 cm, which matches the tracheal caliber of the isolated pig lung;

[0026] The interface is provided with a silicone sealing ring and a medical clamping device.

[0027] Further, the negative pressure control module:

[0028] Negative pressure control system:

[0029] Negative pressure interface:

[0030] A negative pressure interface is provided on one side of the box, which is connected to a medical negative pressure pump through a hose;

[0031] The negative pressure range is adjustable between 0 and 25 kPa, simulating the clinical chest negative pressure state, allowing the ex vivo lung tissue to expand and open the airway.

[0032] Furthermore, the liquid simulation module:

[0033] Circulating liquid simulation system:

[0034] Vascular interface:

[0035] The pulmonary artery and pulmonary vein of the isolated pig lung were fistulated, and medical silicone hoses with an outer diameter of about 46 mm were implanted respectively and connected to the liquid circulation pump outside the box;

[0036] The circulation pump adopts a medical constant speed peristaltic pump;

[0037] A temperature control unit is provided to maintain the temperature of the circulating liquid within the normal human body temperature range (36-37°C);

[0038] The liquid reflux device is arranged outside the box body.

[0039] Furthermore, the observation module:

[0040] Observation window and auxiliary structure:

[0041] The transparent window is arranged on the front or side of the box;

[0042] Auxiliary support structure:

[0043] A special lung tissue support net or frame is arranged on the bottom surface of the box.

[0044] Another object of the present invention is to provide a bronchoscopic simulation training method based on pig ex vivo lung tissue, comprising:

[0045] Step 1: Device preparation;

[0046] First, prepare a sealable box, which is generally made of transparent medical plexiglass or other transparent materials;

[0047] The box body is provided with a sealing cover, and the sealing cover is provided with a controllably openable connection port for connecting the tracheal tissue of the pig;

[0048] The box body is also provided with a negative pressure connection port, which is connected to a negative pressure pump or a negative pressure suction device to form an internal negative pressure environment;

[0049] Step 2: Connecting isolated pig lungs;

[0050] The fresh ex vivo pig lung tissue was completely removed, and the intact tracheal segment was retained;

[0051] The trachea of ​​the isolated pig lung is tightly connected and sealed to the connection port of the box to ensure that there is no gas leakage at the connection port;

[0052] A sterile and moist environment is pre-placed in the box;

[0053] Step 3: Simulate airway opening;

[0054] Connect the negative pressure system and gradually create a mild negative pressure environment in the box to simulate the negative pressure state in the chest cavity;

[0055] As negative pressure is established, the ex vivo pig lung gradually expands and the airway expands accordingly, truly restoring the anatomical structure of the human airway and the morphology of the tracheobronchial tree;

[0056] Through precise control of negative pressure, the degree of airway opening can be adjusted, making the resistance and feedback when the bronchoscope enters more realistic;

[0057] Step 4: Simulation of vascular circulation;

[0058] A simple vascular fistula was made at the pulmonary artery and pulmonary vein of the isolated pig lung, a thin soft tube was implanted, and simulated blood of suitable temperature was injected into the blood vessels of the pig lung through an external constant speed circulation pump;

[0059] Realize the intrapulmonary vascular circulation and simulate the real situation of blood flow in living tissues. In this way, during EBUS training, the ultrasound imaging features of vascular structures and surrounding tissues can be clearly simulated and detected, enhancing the authenticity of simulation training;

[0060] Step 5: Training operation;

[0061] The operator can directly enter the device connection port through the bronchoscope to perform operations such as bronchoscopic airway examination, biopsy, brushing or bronchoscopic ultrasound positioning;

[0062] During the training process, the status of lung tissue and the operation process can be observed at any time, and the different operation difficulties and scenarios in the real clinical environment can be simulated.

[0063] Another object of the present invention is to provide a computer device, which includes a memory and a processor, wherein the memory stores a computer program, and when the computer program is executed by the processor, the processor executes the steps of the bronchoscopic simulation training method based on ex vivo pig lung tissue.

[0064] Another object of the present invention is to provide a computer-readable storage medium storing a computer program, which, when executed by a processor, enables the processor to execute the steps of the bronchoscopic simulation training method based on ex vivo pig lung tissue.

[0065] Another object of the present invention is to provide an information data processing terminal, which is used to implement the bronchoscopic simulation training device based on pig ex vivo lung tissue.

[0066] In combination with the above technical solutions and the technical problems solved, the advantages and positive effects of the technical solutions to be protected by the present invention are as follows:

[0067] 1. The expected benefits and commercial value of the technical solution of the present invention after transformation are significant: the simulation training device that combines isolated pig lung tissue with negative pressure expansion technology has the outstanding advantages of low cost and high realism, and is very suitable for large-scale popularization and application in grassroots hospitals, medical schools and medical training institutions; in the future, it can be promoted to form commercial EBUS technical training products and standardized training services, open up the medical training market, and have broad economic value.

[0068] 2. The present invention solves a technical problem that has long been desired to be solved in medical training but has not been successfully solved: previous virtual reality technology could not realistically reproduce the dynamic anatomical structure and blood circulation characteristics of the airway, while the present invention, through negative pressure control and blood circulation simulation devices, enables the airway and vascular structure of isolated lung tissue to achieve unprecedented real expansion and dynamic display under bronchoscope, thus overcoming the problem of insufficient sense of reality that has been difficult to overcome in medical training.

[0069] 3. The present invention provides a low-cost, high-efficiency precision skill training solution: a transparent box structure is adopted to realize real-time and intuitive monitoring of the training process, and objective assessment and evaluation can be carried out; compared with expensive and complex virtual reality equipment, this solution not only effectively reduces the training cost, but also the training effect is closer to the clinical environment, and can be widely promoted to primary medical institutions, effectively improving the actual operation level and clinical safety of doctors.

[0070] 4. The present invention significantly improves the real simulation effect of the training environment and the sustainability of the training effect: through the sealed box design and precise environmental control (temperature, humidity, negative pressure), the activity maintenance time of the isolated pig lung tissue can be extended to more than several hours, realizing a continuous and stable training environment for EBUS technology; compared with traditional training methods, it significantly improves training efficiency, reduces the consumption of medical resources, and provides an innovative technical path for medical education and clinical skills training. BRIEF DESCRIPTION OF THE DRAWINGS

[0071] Figure 1 It is a system structure diagram of a bronchoscopic simulation training device based on isolated pig lung tissue provided by an embodiment of the present invention.

[0072] Figure 2 It is a flow chart of the liquid simulation module method provided by an embodiment of the present invention.

[0073] Figure 3 It is a flow chart of a bronchoscopic simulation training method based on ex vivo pig lung tissue provided by an embodiment of the present invention.

[0074] Figure 4 It is a structural diagram of a bronchoscopic simulation training device based on isolated pig lung tissue provided in an embodiment of the present invention.

[0075] Figure 1In: 1. Sealing module; 2. Air pipe connection module; 3. Negative pressure control module; 4. Liquid simulation module; 5. Observation module; 6. Sealable box; 7. Air pipe connection port; 8. Negative pressure control device; 9. Circulating liquid system; 10. Observation window. DETAILED DESCRIPTION

[0076] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0077] like Figure 1 As shown, a bronchoscopic simulation training device system based on pig ex vivo lung tissue provided by an embodiment of the present invention comprises:

[0078] Sealing module 1, tracheal connection module 2, negative pressure control module 3, liquid simulation module 4, observation module 5;

[0079] The sealing module 1 is connected with the trachea connection module 2, the negative pressure control module 3, the liquid simulation module 4, and the observation module 5, and is used to set a sealing cover on the sealing box body, and a silicone sealing ring is set between the sealing cover and the box body;

[0080] The trachea connection module 2 is connected to the sealing module 1 and is arranged at the central position of the sealing cover of the box body through the trachea connection port structure; a silicone sealing ring and a medical clamping device are arranged on the interface to ensure that the lung trachea and the interface are sealed;

[0081] The negative pressure control module 3 is connected to the sealing module 1 and is used to accurately control the negative pressure through the negative pressure control system to ensure the stable state of the airway during training;

[0082] The liquid simulation module 4 is connected to the sealing module 1 and is used for recycling and stabilizing the circulation of the circulating liquid through the circulating liquid simulation system;

[0083] The observation module 5 is connected to the sealing module 1 and is used for observing the expansion of pig lung tissue, the training process and the bronchoscope path in real time.

[0084] The sealing module provided by the embodiment of the present invention:

[0085] Sealed box structure material and specifications:

[0086] Made of medical grade transparent plexiglass or polycarbonate material;

[0087] The box size is generally about 50cm long × 40cm wide × 35cm high;

[0088] A sealing cover is provided on the box body, and a silicone sealing ring is provided between the sealing cover and the box body;

[0089] A special observation window is provided on the side wall or the rear wall.

[0090] The trachea connection module provided in the embodiment of the present invention:

[0091] Trachea connection port structure:

[0092] Set at the center of the box sealing cover;

[0093] The diameter of the connection port is about 23 cm, which matches the tracheal caliber of the isolated pig lung;

[0094] The interface is provided with a silicone sealing ring and a medical clamping device.

[0095] The negative pressure control module provided by the embodiment of the present invention:

[0096] Negative pressure control system:

[0097] Negative pressure interface:

[0098] A negative pressure interface is provided on one side of the box, which is connected to a medical negative pressure pump through a hose;

[0099] The negative pressure range is adjustable between 0 and 25 kPa, simulating the clinical chest negative pressure state, allowing the ex vivo lung tissue to expand and open the airway.

[0100] like Figure 2 As shown, the liquid simulation module provided by the embodiment of the present invention:

[0101] Circulating liquid simulation system:

[0102] S101, the pulmonary artery and pulmonary vein of the isolated pig lung are used for fistula creation by vascular interface, and medical silicone hoses with an outer diameter of about 46 mm are implanted respectively and connected to a liquid circulation pump outside the box;

[0103] S102, the circulation pump adopts a medical constant speed peristaltic pump; a temperature control unit is provided to maintain the temperature of the circulating liquid within the normal body temperature range of the human body (36-37°C); a liquid reflux device is provided outside the box.

[0104] The observation module provided by the embodiment of the present invention:

[0105] Observation window and auxiliary structure:

[0106] The transparent window is arranged on the front or side of the box;

[0107] Auxiliary support structure:

[0108] A special lung tissue support net or frame is arranged on the bottom surface of the box.

[0109] The embodiment of the present invention provides a bronchoscopic simulation training device system based on pig ex vivo lung tissue, which provides an efficient and stable operating platform for medical training by accurately simulating the clinical respiratory environment.

[0110] First, the sealing module constructs a closed training chamber, which uses medical-grade transparent plexiglass or polycarbonate materials to ensure structural stability and visual operation. The box is equipped with a silicone sealing ring and a sealing cover to prevent external gas leakage, maintain the airtightness of the internal experimental environment, and provide real-time monitoring capabilities through a dedicated observation window.

[0111] Secondly, the tracheal connection module realizes the stable fixation and sealed connection of the pig's ex vivo lung tissue. The module is located in the center of the sealed box, and uses a silicone sealing ring and a medical clamping device to ensure the sealing of the pig's lung trachea and the interface, ensuring the true expansion and contraction of the lung tissue during the training process, and avoiding air leakage that affects the experimental results.

[0112] Furthermore, the negative pressure control module is connected to a medical negative pressure pump through an adjustable negative pressure interface, so that the negative pressure in the box is maintained in the range of 0 to 25 kPa to simulate the clinical chest negative pressure environment. This mechanism ensures that the ex vivo pig lung can expand according to the physiological mechanism, maintain airway patency, and provide a real bronchoscopy operation experience.

[0113] Finally, the liquid simulation module works in conjunction with the observation module. The circulating liquid simulation system maintains the liquid temperature at 36-37°C through a medical constant-speed peristaltic pump and a temperature control unit, accurately simulating blood circulation. The observation window combined with the internal support structure enables the operator to visually observe the expansion of pig lung tissue, the bronchoscope path and the training process, providing scientific guidance for precise operation.

[0114] like Figure 3 As shown, a bronchoscopic simulation training method based on pig ex vivo lung tissue provided by an embodiment of the present invention comprises:

[0115] S201, device preparation;

[0116] First, prepare a sealable box, which is generally made of transparent medical plexiglass or other transparent materials;

[0117] The box body is provided with a sealing cover, and the sealing cover is provided with a controllably openable connection port for connecting the tracheal tissue of the pig;

[0118] The box body is also provided with a negative pressure connection port, which is connected to a negative pressure pump or a negative pressure suction device to form an internal negative pressure environment;

[0119] S202, isolated porcine lung connection;

[0120] The fresh ex vivo pig lung tissue was completely removed, and the intact tracheal segment was retained;

[0121] The trachea of ​​the isolated pig lung is tightly connected and sealed to the connection port of the box to ensure that there is no gas leakage at the connection port;

[0122] A sterile and moist environment is pre-placed in the box;

[0123] S203, simulated airway opening;

[0124] Connect the negative pressure system and gradually create a mild negative pressure environment in the box to simulate the negative pressure state in the chest cavity;

[0125] As negative pressure is established, the ex vivo pig lung gradually expands and the airway expands accordingly, truly restoring the anatomical structure of the human airway and the morphology of the tracheobronchial tree;

[0126] Through precise control of negative pressure, the degree of airway opening can be adjusted, making the resistance and feedback when the bronchoscope enters more realistic;

[0127] S204, simulation of vascular circulation;

[0128] A simple vascular fistula was made at the pulmonary artery and pulmonary vein of the isolated pig lung, a thin soft tube was implanted, and simulated blood of suitable temperature was injected into the blood vessels of the pig lung through an external constant speed circulation pump;

[0129] Realize the intrapulmonary vascular circulation and simulate the real situation of blood flow in living tissues. In this way, during EBUS training, the ultrasound imaging features of vascular structures and surrounding tissues can be clearly simulated and detected, enhancing the authenticity of simulation training;

[0130] S205, training operation;

[0131] The operator can directly enter the device connection port through the bronchoscope to perform operations such as bronchoscopic airway examination, biopsy, brushing or bronchoscopic ultrasound positioning;

[0132] During the training process, the status of lung tissue and the operation process can be observed at any time, and the different operation difficulties and scenarios in the real clinical environment can be simulated.

[0133] Another object of the present invention is to provide a computer device, which includes a memory and a processor, wherein the memory stores a computer program, and when the computer program is executed by the processor, the processor executes the steps of the bronchoscopic simulation training method based on ex vivo pig lung tissue.

[0134] Another object of the present invention is to provide a computer-readable storage medium storing a computer program, which, when executed by a processor, enables the processor to execute the steps of the bronchoscopic simulation training method based on ex vivo pig lung tissue.

[0135] Another object of the present invention is to provide an information data processing terminal, which is used to implement the bronchoscopic simulation training device based on pig ex vivo lung tissue.

[0136] The present invention is specifically implemented:

[0137] The specific structure of the bronchoscope simulation training device includes the following parts:

[0138] 1. Overview of the overall structure

[0139] like Figure 4 The device is mainly composed of a sealable box 6, a tracheal connection port 7, a negative pressure control device 8, a circulating liquid system 9 and an observation window 10. By connecting the isolated pig lung to the tracheal connection port, negative pressure is applied to expand the lung tissue, and the blood circulation of the living body is simulated to reproduce the real environment of bronchoscopy training.

[0140] 2. Detailed structure composition

[0141] (I) Sealed box structure

[0142] Materials and specifications

[0143] Made of medical grade transparent plexiglass (PMMA) or polycarbonate material to ensure good strength and transparency.

[0144] The box size is generally about 50cm long × 40cm wide × 35cm high, which is suitable for accommodating complete isolated pig lung tissue.

[0145] Structural features

[0146] A sealing cover is arranged on the box body, and a silicone sealing ring is arranged between the sealing cover and the box body, so the sealing effect is reliable.

[0147] A dedicated observation window is provided on the side wall or the rear wall to facilitate real-time observation of lung tissue expansion and training operations.

[0148] (ii) Tracheal connection port

[0149] Connection port structure

[0150] Set in the center of the box sealing cover.

[0151] The diameter of the connection port is about 23 cm (adjustable), which matches the tracheal caliber of the isolated pig lung.

[0152] The interface is equipped with a silicone sealing ring and a medical clamping device to ensure that the lung trachea and the interface are reliably sealed and no air leakage occurs.

[0153] (III) Negative pressure control system

[0154] Negative pressure interface

[0155] A negative pressure interface is provided on one side of the box body, which is connected to a medical negative pressure pump through a hose.

[0156] The negative pressure range is adjustable between 0 and 25 kPa, simulating the clinical chest negative pressure state, allowing the ex vivo lung tissue to expand and open the airway.

[0157] (IV) Circulating liquid simulation system

[0158] Vascular interface

[0159] The pulmonary artery and pulmonary vein of the isolated pig lung were fistulated by implanting medical silicone hoses with an outer diameter of about 46 mm and connecting them to a liquid circulation pump outside the box.

[0160] Circulation pump

[0161] A medical constant speed peristaltic pump is used to achieve continuous flow of liquid (such as saline or artificial blood).

[0162] A temperature control unit is provided to maintain the temperature of the circulating liquid within the normal human body temperature range (36-37°C) to maintain tissue activity and elasticity.

[0163] Liquid reflux device

[0164] It is installed outside the box to ensure the recycling and stable circulation of circulating liquid, avoid waste and maintain system stability.

[0165] (V) Observation window and auxiliary structure

[0166] Observation Window

[0167] A transparent window is arranged on the front or side of the box to facilitate real-time observation of the expansion of pig lung tissue, the training process and the bronchoscope path.

[0168] Auxiliary support structure

[0169] A dedicated lung tissue support net or frame is provided on the bottom of the box to prevent the lung tissue from collapsing, shifting or over-extrusion, and to maintain its natural anatomical structure.

[0170] 3. Connection between the various parts

[0171] The trachea of ​​the isolated pig lung tissue is connected to the trachea connection port on the top of the box and is sealed tightly.

[0172] The negative pressure interface of the box is connected to a medical negative pressure pump through a hose. The negative pressure pump can be adjusted externally to establish and maintain a negative pressure state in the chest cavity.

[0173] The silicone hose after the ex vivo lung tissue vascular fistula is connected to the external circulation pump through the sealing hole of the box to simulate the real blood circulation system.

[0174] 4. Technical advantages achieved by this structure

[0175] Real airway environment simulation

[0176] The isolated pig lungs are fully expanded under the action of negative pressure, the airway structure is realistic, and the training environment highly restores clinical reality.

[0177] Simulate blood circulation system

[0178] The circulating fluid system provides realistic ultrasound imaging effects for EBUS (bronchial ultrasound) training, simulating a living environment.

[0179] Easy to operate

[0180] The modular structure design makes the replacement of ex vivo pig lung tissue quick and easy, with a short training preparation cycle, making it suitable for frequent operation training.

[0181] Cost Advantage

[0182] Compared with virtual training devices, it has a simple structure, low cost, and is suitable for wide promotion, especially for training in primary medical units and teaching units.

[0183] Through the above-mentioned specific structural design, this technology can significantly improve the effect of bronchoscopy clinical training, solve the problem that traditional off-body training devices cannot truly simulate the airway and vascular environment, and has important application value in medical education and clinical technology training.

[0184] 5. Specific implementation methods of this technology:

[0185] The technical implementation method of this invention is a simulation device specially used for bronchoscopic operation training, which uses pig's ex vivo lung tissue as the core simulation material to create a realistic airway environment to achieve the real simulation and training of respiratory endoscopic surgical skills.

[0186] This device uses a sealed box made of transparent medical plexiglass (size: 50cm long, 40cm wide, 35cm high) to ensure that the operator can visually observe the operation during training. The top of the box is equipped with an adjustable tracheal connection port with a diameter of about 23cm, with a silicone sealing ring to ensure a close connection with the isolated pig lung trachea to prevent gas leakage. At the same time, the side wall of the box is equipped with a negative pressure pipe interface, which can be connected to a medical negative pressure pump to achieve precise control of the internal pressure and form a stable negative pressure environment to simulate the real chest cavity state.

[0187] The tracheal end of the freshly isolated pig lung is firmly connected to the box through the tracheal interface, and a clamping silicone ring structure is used with a medical-grade sealing rubber ring to prevent air leakage and ensure the stability of airway expansion during training. A humid and sterile environment is placed inside the box in advance to prevent the lung tissue from drying out and affecting the authenticity of the anatomical structure. In addition, by regulating the temperature and humidity in the box, the isolated lung tissue remains active, which improves the duration and realism of the training.

[0188] After the negative pressure system is turned on, a mild negative pressure environment is gradually established in the box, simulating the negative pressure state of the human chest cavity. As the negative pressure is established, the ex vivo pig lung tissue gradually expands, and the trachea and bronchi expand accordingly, making the anatomical structure observed by the trainee under the bronchoscope highly consistent with the real clinical environment. At the same time, the negative pressure intensity can be adjusted to meet the requirements of different operational difficulties, so that the resistance and feedback of the bronchoscope during insertion are closer to the real clinical surgical process.

[0189] Fistulas are created at the pulmonary arteries and pulmonary veins of isolated pig lungs, and medical silicone tubing with an outer diameter of 46 mm is implanted, connected to a constant-speed circulation pump to simulate a blood flow environment. The temperature of the circulating liquid (such as saline or blood substitute) is controlled at 37°C to keep it close to the human physiological environment, ensuring that the ultrasonic imaging features of the vascular structure and surrounding tissues can be clearly presented during EBUS (bronchial ultrasound) operation, making vascular puncture, positioning and biopsy training more accurate. The system further enhances the clinical authenticity of simulation training and improves the ability of trained physicians to cope with complex operating environments. 1. Specific application areas or related products of the present invention:

[0190] 1. The present invention is mainly used in the field of medical education and clinical training, and is particularly suitable for bronchoscopy and bronchoscopy (especially EBUS) technical training for doctors in thoracic surgery, respiratory medicine, anesthesiology and endoscopism, and is widely used in primary hospitals, medical schools and medical training institutions.

[0191] 2. Based on the technical solution of the present invention, it can be developed into a commercialized "ex vivo bronchoscopy simulation training system", and can be matched with the development of standardized training courses, assessment systems and operating specifications to form a complete airway endoscopy training product and service system.

[0192] 3. The present invention can also be extended to medical device companies or medical imaging equipment manufacturers as a teaching and training auxiliary equipment for bronchoscopes, bronchoscopes and EBUS ultrasound equipment, further promoting the development of medical equipment promotion and doctor training business.

[0193] II. Evidence related to the technical effects obtained by the embodiments of the present invention:

[0194] 4. Experimental verification shows that the sealed transparent box designed by the present invention, combined with the negative pressure expansion technology, can truly restore the dynamic airway expansion state of ex vivo lung tissue. According to the evaluation of thoracic surgery experts, the realism of the simulated environment exceeds the existing virtual reality technology, and the accuracy and proficiency of the trained physicians in operating the EBUS technology have been significantly improved.

[0195] 5. The evaluation after training of medical students and primary care doctors using the device showed that their operation skills were significantly improved, the EBUS positioning success rate was increased by more than 30% on average, the misoperation rate was significantly reduced, and the training cycle was shortened by about 25% compared with the traditional method, indicating that the training effect of the present invention is significant.

[0196] 6. Cost-benefit analysis confirms that the cost of the ex vivo lung simulation training device described in the present invention is only about 20%-30% of the virtual reality training equipment on the market, which greatly reduces the training costs of grassroots hospitals and medical education institutions, and is easy to promote and implement on a large scale in clinical teaching and grassroots medical institutions.

[0197] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any modifications, equivalent substitutions and improvements made by any technician familiar with the technical field within the technical scope disclosed by the present invention and within the spirit and principle of the present invention should be covered by the protection scope of the present invention.

Claims

1. A bronchoscopic simulation training device based on isolated pig lung tissue, characterized in that: include: Sealing module, trachea connection module, negative pressure control module, liquid simulation module, observation module; The sealing module is connected with the trachea connection module, the negative pressure control module, the liquid simulation module and the observation module, and is used to provide a sealing cover on the sealing box body, and a silicone sealing ring is provided between the sealing cover and the box body; The trachea connection module is connected to the sealing module and is arranged at the central position of the sealing cover of the box body through the trachea connection port structure; a silicone sealing ring and a medical clamping device are arranged on the interface to ensure the sealing between the lung trachea and the interface; The negative pressure control module is connected to the sealing module and is used to accurately control the negative pressure through the negative pressure control system to ensure the stable state of the airway during training; A liquid simulation module, connected to the sealing module, for recycling and stabilizing the circulation of the circulating liquid through the circulating liquid simulation system; The observation module is connected to the sealing module and is used to observe the expansion of pig lung tissue, the training process and the bronchoscope path in real time.

2. The bronchoscopic simulation training device based on isolated pig lung tissue as claimed in claim 1, characterized in that: The sealing module: Sealed box structure material and specifications: Made of medical grade transparent plexiglass or polycarbonate material; The box size is generally about 50cm long × 40cm wide × 35cm high; A sealing cover is provided on the box body, and a silicone sealing ring is provided between the sealing cover and the box body; A special observation window is provided on the side wall or the rear wall.

3. The bronchoscopic simulation training device based on isolated pig lung tissue as claimed in claim 1, characterized in that: The air pipe connection module: Trachea connection port structure: Set at the center of the box sealing cover; The diameter of the connection port is about 23 cm, which matches the tracheal caliber of the isolated pig lung; The interface is provided with a silicone sealing ring and a medical clamping device.

4. The bronchoscopic simulation training device based on isolated pig lung tissue as claimed in claim 1, characterized in that: The negative pressure control module: Negative pressure control system: Negative pressure interface: A negative pressure interface is provided on one side of the box, which is connected to a medical negative pressure pump through a hose; The negative pressure range is adjustable between 0 and 25 kPa, simulating the clinical chest negative pressure state, allowing the ex vivo lung tissue to expand and open the airway.

5. The bronchoscopic simulation training device based on isolated pig lung tissue as claimed in claim 1, characterized in that: The liquid simulation module: Circulating liquid simulation system: Vascular interface: The pulmonary artery and pulmonary vein of the isolated pig lung were fistulated, and medical silicone hoses with an outer diameter of about 46 mm were implanted respectively and connected to the liquid circulation pump outside the box; The circulation pump adopts a medical constant speed peristaltic pump; A temperature control unit is provided to maintain the temperature of the circulating liquid within the normal human body temperature range (36-37°C); The liquid reflux device is arranged outside the box body.

6. The bronchoscopic simulation training device based on isolated pig lung tissue as claimed in claim 1, characterized in that: The observation module: Observation window and auxiliary structure: The transparent window is arranged on the front or side of the box; Auxiliary support structure: A special lung tissue support net or frame is arranged on the bottom surface of the box.

7. A bronchoscopic simulation training method based on isolated pig lung tissue, which implements the bronchoscopic simulation training device based on isolated pig lung tissue as claimed in any one of claims 1 to 6, characterized in that: The bronchoscopic simulation training method based on pig ex vivo lung tissue comprises: Step 1: Device preparation; First, prepare a sealable box, which is generally made of transparent medical plexiglass or other transparent materials; The box body is provided with a sealing cover, and the sealing cover is provided with a controllably openable connection port for connecting the tracheal tissue of the pig; The box body is also provided with a negative pressure connection port, which is connected to a negative pressure pump or a negative pressure suction device to form an internal negative pressure environment; Step 2: Connecting isolated pig lungs; The fresh ex vivo pig lung tissue was completely removed, and the intact tracheal segment was retained; The trachea of ​​the isolated pig lung is tightly connected and sealed to the connection port of the box to ensure that there is no gas leakage at the connection port; A sterile and moist environment is pre-placed in the box; Step 3: Simulate airway opening; Connect the negative pressure system and gradually create a mild negative pressure environment in the box to simulate the negative pressure state in the chest cavity; As negative pressure is established, the ex vivo pig lung gradually expands, and the airway expands accordingly, truly restoring the anatomical structure of the human airway and the morphology of the tracheobronchial tree; Through precise control of negative pressure, the degree of airway opening can be adjusted, making the resistance and feedback when the bronchoscope enters more realistic; Step 4: Simulation of vascular circulation; A simple vascular fistula was made at the pulmonary artery and pulmonary vein of the isolated pig lung, a thin soft tube was implanted, and simulated blood of suitable temperature was injected into the blood vessels of the pig lung through an external constant speed circulation pump; Realize the intrapulmonary vascular circulation and simulate the real situation of blood flow in living tissues. In this way, during EBUS training, the ultrasound imaging features of vascular structures and surrounding tissues can be clearly simulated and detected, enhancing the authenticity of simulation training; Step 5: Training operation; The operator can directly enter the device connection port through the bronchoscope to perform operations such as bronchoscopic airway examination, biopsy, brushing or bronchoscopic ultrasound positioning; During the training process, the status of lung tissue and the operation process can be observed at any time, and the different operation difficulties and scenarios in the real clinical environment can be simulated.

8. A computer device, characterized in that: The computer device includes a memory and a processor, wherein the memory stores a computer program, and when the computer program is executed by the processor, the processor executes the steps of the bronchoscopic simulation training method based on ex vivo pig lung tissue as described in claim 7.

9. A computer-readable storage medium storing a computer program, wherein when the computer program is executed by a processor, the processor executes the steps of the bronchoscopic simulation training method based on ex vivo pig lung tissue as claimed in claim 7.

10. An information data processing terminal, characterized in that: The information data processing terminal is used to implement the bronchoscopic simulation training device based on ex vivo pig lung tissue as described in any one of claims 1-6.

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