Sample target plate, sample target groove and mass spectrometer

Abstract

The invention discloses a sample target plate. The sample target plate comprises a target holder and a target surface, at least two groups of target point units are arranged on the upper surface of the target surface, the target holder is provided with a first plane, the first plane is used for bearing the target surface, and the sample target plate is matched with a sample target groove of a mass spectrometer through the target holder; the target point unit comprises a plurality of target points which are sequentially arranged in the first direction, and the target points are used for bearing samples; after the sample target plate is mounted in the sample target groove, the target units of which at least part of targets are sequentially positioned at the detection position of the mass spectrometer are target target units along with the movement of the sample target groove; the target surface is matched with the target holder in at least two directions; and / or the target holder is matched with the sample target groove in at least two directions; when the target surface and / or the target holder are / is changed in different directions and mounted in the sample target groove, different target point units sequentially become target point units; the position precision in the target plate detection process is improved, and the sample detection quantity on the same target plate can be improved.

Description

Technical Field

[0001] The invention relates to the technical field of mass spectrometry detection, and in particular to a sample target plate, a sample target groove and a mass spectrometer. Background Art

[0002] A mass spectrometer, also known as a mass spectrometer, is centered around a mass analyzer and an ion detector, and is designed to separate substances and detect their composition. The ion source is used to ionize sample molecules under high vacuum conditions, the mass analyzer is used to separate ions of different masses, and the ion detector is used to collect and amplify ion signals to provide data for the computer to draw a mass spectrum. A mass spectrometer is centered around an ion source, a mass analyzer, and an ion detector. The ion source is a device that moves the sample back and forth, left and right, under high vacuum conditions, and the mass analyzer and ion detector also require the sample to be placed on the detection channel.

[0003] Since the mass spectrometer separates and detects atoms, molecules or molecular fragments of a substance based on the principle that charged particles can be deflected in an electromagnetic field, the ions are bombarded with energy and fly upward to the detector. The flight channel does not need to move or change, and samples at different positions are sampled by moving the coordinates of the motion platform.

[0004] Existing mass spectrometers all use an XY cross motion mechanism as the power source for the reciprocating motion of the target plate. The XY cross motion mechanism requires the cooperation of two sets of guide mechanisms in two directions, which affects the movement accuracy of the target plate. In addition, the two sets of guide mechanisms occupy a large space, which makes the volume of the vacuum chamber accommodating the motion mechanism larger, affecting the vacuum pumping efficiency. If one set of guide mechanisms is used as the power source for the reciprocating motion of the target plate, the sample needs to be arranged along the moving direction of the guide mechanism, which cannot meet the needs of some customers for the sample detection volume on the same target plate.

[0005] Therefore, how to provide a sample target plate, a sample target slot and a mass spectrometer to at least partially solve the above-mentioned drawbacks is a technical problem that technicians in this field currently need to solve. Summary of the invention

[0006] The object of the present invention is to provide a sample target plate, a sample target slot and a mass spectrometer, which can improve the sample detection amount on the same target plate compared to a sample target plate with only one set of target point units.

[0007] To achieve the above object, the present invention provides a sample target plate, which is used to carry a sample and is configured to be installed in cooperation with a sample target slot of a mass spectrometer to achieve mass spectrometry detection of the sample. The sample target plate includes a target holder and a target surface; At least two groups of target point units are arranged on the upper surface of the target surface, the target holder is provided with a first plane, the first plane is used to carry the target surface, and the sample target plate is installed in cooperation with the sample target slot of the mass spectrometer through the target holder; The target point unit includes a plurality of target points sequentially arranged along a first direction, and the target points are used to carry samples; when the sample target plate is mounted to the sample target slot, a target point unit that can realize at least part of the target points sequentially being located at the mass spectrometer detection position as the sample target slot moves is a target target point unit; The target surface is installed in cooperation with the target holder in at least two orientations; and / or the target holder is installed in cooperation with the sample target slot in at least two orientations; when the target surface and / or the target holder changes to different orientations and is installed in the sample target slot, different target point units become target target point units in turn.

[0008] Preferably, there are two groups of target units, and the two groups of target units are arranged in parallel on the upper surface of the target surface; When the sample target plate is installed in the sample target slot, one group of target point units is the target target point units; When the target holder is horizontally rotated 180° and installed in the sample target groove, or the target surface is horizontally rotated 180° and installed in the target holder, the other group of target point units is the target target point units.

[0009] Preferably, there are four groups of target units, and the four groups of target units are arranged in parallel on the upper surface of the target surface; When the sample target plate is installed in the sample target slot, one group of target point units is the target target point units; When the target surface is horizontally rotated 180° with the target holder and installed in the sample target groove, the target holder is stationary and the target surface is horizontally rotated 180° and installed in the target holder, or the target holder is horizontally rotated 180° and installed in the sample target groove and the target surface is horizontally rotated 180° and installed in the target holder, the other three groups of target point units are target target point units in turn.

[0010] Preferably, the target holder is provided with a slide groove for the target surface to slide into, a slide entrance is provided at one end of the slide groove in the sliding direction, and a limit portion is provided at the other end of the slide groove in the sliding direction, the limit portion is used to abut against the corner of the target surface to limit the sliding distance of the target surface.

[0011] Preferably, the target holder is provided with a third through hole and a fourth through hole, the third through hole can be assembled with the third positioning piece on the sample target groove, and the fourth through hole can be assembled with the fourth positioning piece on the sample target groove.

[0012] Preferably, the upper surface of the target surface further includes a second identification mark, and the second identification mark is used for identifying different target surfaces and / or different target point units and / or different target points and / or sample information on different target points.

[0013] The present invention also provides a sample target slot, which is arranged in a mass spectrometer and is used to carry the above-mentioned sample target plate. The sample target slot is provided with at least two installation positions. Correspondingly, at least two groups of target point units are arranged on the sample target plate. When the sample target plate is installed to different installation positions in the sample target slot, different target point units become target target point units in turn.

[0014] The present invention also provides a mass spectrometer, comprising the sample target groove.

[0015] Preferably, the mass spectrometer further comprises a motion mechanism capable of driving the sample target groove to move along the first direction.

[0016] Compared with the above background technology, the sample target plate provided by the present invention is used to carry samples and is configured to be installed in cooperation with the sample target slot of the mass spectrometer to realize mass spectrometry detection of the samples. The sample target plate includes a target holder and a target surface; at least two groups of target units are arranged on the upper surface of the target surface, and the target holder is provided with a first plane, which is used to carry the target surface, and the sample target plate is installed in cooperation with the sample target slot of the mass spectrometer through the target holder; the target unit includes a plurality of targets arranged in sequence along a first direction, and the target points are used to carry the samples; when the sample target plate is installed in the sample target slot, the target unit that can realize at least part of the targets being located in sequence at the detection position of the mass spectrometer as the sample target slot moves is the target target unit; the target surface is installed in cooperation with the target holder in at least two orientations; and / or the target holder is installed in cooperation with the sample target slot in at least two orientations; when the target surface and / or the target holder changes to different orientations and is installed in the sample target slot, different target units become target target units in sequence.

[0017] Specifically, at least two groups of target point units are arranged on the target surface, and the at least two groups of target point units each include a plurality of target points sequentially arranged along a first direction for carrying samples, thereby increasing the number of target points on the target surface, thereby increasing the number of samples that can be carried at a single time, and the target surface is installed in cooperation with the target holder in at least two orientations; and / or the target holder is installed in cooperation with the sample target slot in at least two orientations; after the sample target plate is placed in the sample target slot, a group of target point units is realized as the target target point unit through the unidirectional movement of the sample target slot, and the targets in the target unit are sequentially located at the detection position of the mass spectrometer for detection, and the group of target point units is waited for After the element detection is completed, the sample target plate is installed in another orientation in conjunction with the sample target slot, and then the sample target slot is moved unidirectionally to realize another group of target units as target target units. The targets in the target units are located in turn at the detection position of the mass spectrometer for detection. In this way, only the sample target slot moves in one direction, and the installation method between the target surface and the target holder and between the target holder and the sample target slot is adjusted to complete the detection of two or more groups of target units, which can improve the position accuracy of the target plate detection process. At the same time, compared with the sample target plate with only one group of target units, it can increase the sample detection volume on the same target plate. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0019] Figure 1 A schematic diagram of the structure of a target surface provided by an embodiment of the present invention; Figure 2 A schematic diagram of the structure of a target holder provided by an embodiment of the present invention; Figure 3 for Figure 2 The main view of Figure 4 for Figure 2 Rear view of Figure 5 for Figure 3 Sectional view along AA; Figure 6 A schematic diagram of the structure of the target surface provided by an embodiment of the present invention being assembled to the target holder; Figure 7 for Figure 6 A top view of Figure 8 for Figure 6 Exploded diagram of Fig. 9 A schematic diagram of the structure of a sample target groove provided by an embodiment of the present invention; Fig.10 A cross-sectional view of a sample target groove provided by an embodiment of the present invention; Fig.11 A schematic diagram of the structure when the target surface provided by an embodiment of the present invention is horizontally rotated 180°; Fig.12 A schematic diagram of the structure of the target holder provided by an embodiment of the present invention when it is horizontally rotated 180°; Fig.13 A schematic diagram of the structure of the target holder provided by an embodiment of the present invention being assembled to the sample target groove; Fig.14 A schematic diagram of the structure of the sample target holder injection provided by an embodiment of the present invention; Fig.15 for Fig.14 A partial enlarged view of Fig.16 A schematic structural diagram of another perspective of sample target holder injection provided by an embodiment of the present invention; Fig.17 A schematic diagram of the structure of the motion direction of the motion mechanism provided by an embodiment of the present invention; Fig.18A schematic diagram of the structure of a target point unit in group A of the target surface provided by an embodiment of the present invention as a target target unit; Fig.19 A schematic diagram of the structure in which the target point units of group B in the target surface provided by the embodiment of the present invention are target target units; Fig. 20 A schematic diagram of the structure of a target point unit in a group D in a target surface provided by an embodiment of the present invention as a target target unit; Fig.21 A schematic diagram of the structure of a target point unit in group C in a target surface provided by an embodiment of the present invention as a target target unit; Fig. 22 A schematic diagram of the structure of another sample target groove provided by an embodiment of the present invention; Fig.23 A schematic structural diagram of a target surface provided with two groups of target units in an embodiment of the present invention, in which a group B of target units are target target units; Fig.24 A schematic structural diagram of a target surface provided with two groups of target units in an embodiment of the present invention, in which a group A of target units is a target target unit.

[0020] in: 100-target surface, 111-target point, 112-central axis, 113-column number identification code, 114-position identification code, 115-corner, 116-column number identification label, 117-barcode area, 118-target plate number, 119-first through hole, 120-second through hole; 200-target holder, 210-first plane, 211-third through hole, 212-fourth through hole, 220-guide member, 221-first end, 222-second end, 223-limiting portion, 224-second plane, 225-second chamfer, 230-first notch, 240-second notch, 250-first magnetic member, 260-protective sheet, 270-pick-and-place position, 280-positioning groove; 300-sample target groove, 310-second groove, 311-first protrusion, 312-third positioning member, 313-fourth positioning member, 320-removal and placement groove, 330-second magnetic member, 340-avoidance position; 400-cover plate; 500-Movement mechanism. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] In order to enable those skilled in the art to better understand the scheme of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0023] In the description of the present invention, it is necessary to understand that the orientations or positional relationships indicated by the terms "upper", "lower", "top", "bottom", etc. are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the position or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as a limitation of the present invention.

[0024] The purpose of the present invention is to provide a sample target plate, a sample target groove 300 and a mass spectrometer, which can improve the position accuracy during the target plate detection process, and at the same time, compared with a sample target plate with only one set of target point units, can increase the sample detection amount on the same target plate.

[0025] It should be noted that, in this embodiment, the X direction in the drawings is defined as the first direction, and the Y direction is defined as the second direction, and the first direction and the second direction are perpendicular to each other.

[0026] See also Figures 1 to 24 To achieve the above-mentioned purpose, the present invention provides a sample target plate, which is used to carry samples and is configured to be installed in cooperation with a sample target slot 300 of a mass spectrometer to realize mass spectrometry detection of the samples. The sample target plate includes a target holder 200 and a target surface 100; the target surface 100 is a flat thin plate, which can be made of ultra-thin silicon steel, ceramic material, plastic material, etc., and at least two groups of target point units are arranged on the upper surface of the target surface 100. The target holder 200 is provided with a first plane 210, and the first plane 210 is used to carry the target surface 100. The sample target plate is connected to the mass spectrometer through the target holder 200. The target unit includes a plurality of targets 111 arranged in sequence along a first direction, that is, the central axis 112 of the same target unit extends along the first direction, and the target 111 is used to carry the sample; when the sample target plate is installed in the sample target slot 300, the target unit that can realize at least part of the target points 111 (preferably all the target points 111 in this embodiment) being located in sequence at the detection position of the mass spectrometer along with the movement of the sample target slot 300 is the target target unit, that is, the target unit placed at the detection position is the target target unit, and the detection position can refer to the attached Fig.18 To Attachment Fig.24 At the M mark in the figure, the target unit corresponding to the M mark is the target target unit; the target surface 100 is installed in cooperation with the target holder 200 in at least two orientations; and / or the target holder 200 is installed in cooperation with the sample target groove 300 in at least two orientations; when the target surface 100 and / or the target holder 200 changes to different orientations and is installed in the sample target groove 300, different target units become target target units in turn.

[0027] Among them, the target surface 100 is installed in cooperation with the target holder 200 in at least two orientations, including but not limited to the rotation and translation of the target surface 100 relative to the target holder 200, and the target holder 200 is installed in cooperation with the sample target groove 300 in at least two orientations, also including but not limited to the rotation and translation of the target holder 200 relative to the sample target groove 300. Taking the case where the target units are set into two groups, namely the first group of target units and the second group of target units, as an example, when the sample target plate is installed in cooperation with the sample target slot 300 in one orientation, it can ensure that the first group of target units are located at a preset position in the sample target slot 300 (the preset position can be the position of the target unit), and the detection of samples on each target point 111 in the first group of target units is completed under the drive of the sample target slot 300, and then the orientation of the sample target plate relative to the sample target slot 300 is adjusted so that the first group of target units move out of the preset position and the second group of target units are located at the preset position in the sample target slot 300, and the detection of samples on each target point 111 in the second group of target units is completed under the drive of the sample target slot 300, wherein the orientation change of the sample target plate relative to the sample target slot 300 includes but is not limited to the rotation of the target surface 100 and the rotation and translation of the target holder 200.

[0028] Specifically, at least two groups of target point units are arranged on the target surface 100, and the at least two groups of target point units each include a plurality of target points 111 sequentially arranged along a first direction for carrying samples, thereby increasing the number of target points 111 on the target surface 100, thereby increasing the number of samples that can be carried at a time (in the present application, the number of samples that can be carried at a time refers to the number of samples that the sample target plate can carry at one time, which is basically equivalent to the number of target points 111 on the target surface 100), the target surface 100 is installed in cooperation with the target holder 200 in at least two orientations; and / or the target holder 200 is installed in cooperation with the sample target groove 300 in at least two orientations; after the sample target plate is placed in the sample target groove 300, a group of target point units is realized as the target target unit through the unidirectional movement of the sample target groove 300, The targets 111 in the target unit are sequentially located at the detection position of the mass spectrometer for detection. After the detection of this group of target units is completed, the sample target plate is installed in another orientation in conjunction with the sample target slot 300. Then, through the unidirectional movement of the sample target slot 300, another group of target units is realized as the target target unit. The targets 111 in the target unit are sequentially located at the detection position of the mass spectrometer for detection. In this arrangement, only the sample target slot 300 moves in one direction, and the installation method between the target surface 100 and the target holder 200 and between the target holder 200 and the sample target slot 300 is adjusted to complete the detection of two or more groups of target units, which can improve the position accuracy of the target plate detection process. At the same time, compared with the sample target plate with only one group of target units, the sample detection amount on the same target plate can be increased.

[0029] In one embodiment, two groups of target units are provided, and the two groups of target units are arranged in parallel on the upper surface of the target surface 100; when the sample target plate is installed in the sample target groove 300, one group of target units is the target target unit; when the target holder 200 is horizontally rotated 180° and installed in the sample target groove 300, or the target surface 100 is horizontally rotated 180° and installed in the target holder 200, the other group of target units is the target target unit; that is, the detection of one group of target units is completed by installing the sample target plate including the target holder 200 and the target surface 100 in the sample target groove 300, and then the detection of the other group of target units is completed by installing the sample target plate including the target holder 200 and the target surface 100 in the sample target groove 300 after the target holder 200 is horizontally rotated 180° or the target surface 100 is horizontally rotated 180° and then the sample target plate is installed as a whole in the sample target groove 300.

[0030] Furthermore, if Figures 18 to 21 As shown, there are four groups of target units, and the four groups of target units are arranged in parallel on the upper surface of the target surface 100; Fig.18 As shown, when the sample target plate is installed in the sample target slot 300, the target point units of group A are the target target point units; Fig.19 As shown, when the target holder 200 is stationary and the target surface 100 is horizontally rotated 180° and installed into the target holder 200, the target point units of group B are the target target points; Fig. 20 As shown, in Fig.18 On the basis of, when the target surface 100 is horizontally rotated 180° with the target holder 200 and installed in the sample target groove 300, the target point unit of group D is the target target point unit; Fig.21 As shown, in Fig.18 On the basis of, when the target holder 200 drives the target surface 100 to rotate horizontally 180° and install it into the sample target groove 300, and the target surface 100 is rotated horizontally 180° and installed into the target holder 200, the C group of target units are the target target units, wherein there is no actual sequence requirement for the detection of the four groups of target units. For example, the target surface 100 can be horizontally rotated 180° first and then installed into the target holder 200 again, and the target holder 200 can remain stationary relative to the sample target groove 300 to detect the second group of target units as target target units, and then the target surface 100 does not move and the target holder 200 rotates 180° and then cooperates with another position of the sample target groove 300 to realize the detection of the third group of target units, and then the target holder 200 does not move and the target surface 100 rotates 180° relative to the target holder 200 to realize the detection of the fourth group of target units.

[0031] In one embodiment, the target holder 200 is provided with a slide groove for the target surface 100 to slide in, and a sliding entrance is provided at one end of the slide groove in the sliding direction, and a limit portion 223 is provided at the other end of the slide groove in the sliding direction, and the limit portion 223 is used to abut against the corner portion 115 of the target surface 100 to limit the sliding distance of the target surface 100; the target holder 200 is provided with a first plane 210, and two mutually parallel guide members 220 arranged at intervals on the first plane 210, and the two guide members 220 extend toward each other at one end away from the first plane 210 to form a first guide groove, and the above-mentioned slide groove is formed between the two first guide grooves, and the first guide groove can be slidably matched with both sides of the target surface 100 in the second direction, so that the target surface 100 can slide onto the first plane 210, thereby avoiding the problem that the target plate is easily placed on the target holder 200 from top to bottom. The problem of uneven target plate height; the two guide members 220 each include a first end 221 and a second end 222, a sliding entrance for the target surface 100 to slide into the first plane 210 is formed between the two first ends 221, and a limiting portion 223 is provided on the opposite side of the two second ends 222, and the limiting portion 223 can abut against the corners 115 on the target surface 100 to limit the sliding distance of the target surface 100, and when the target surface 100 slides along the first guide groove until the two corners 115 at one end abut against the limiting portion 223, the target surface 100 moves into place, and when the target surface 100 is detected after the first group of target point units are detected, the target surface 100 is slid out along the first guide groove, and the other end of the target surface 100 is placed in the sliding entrance, and continues to slide along the first guide groove until the two corners 115 at this end abut against the limiting portion 223, and the target surface 100 moves into place again.

[0032] When only two groups of target units are set on the target surface 100, the detection of the two groups of target units can be achieved by horizontally rotating the target holder 200 by 180°, and the corners 115 on the target surface 100 can be set differently. For example, the four corners 115 of the target surface 100 are set to two large chamfers and two small chamfers, and only the two large chamfers can abut against the limit portion 223 to prevent the staff from installing it upside down.

[0033] Furthermore, the target holder 200 also includes a first notch 230 and a second notch 240, the first notch 230 is located between the two first ends 221; the second notch 240 is arranged at the end of the target holder 200 away from the first notch 230; the first notch 230 and the second notch 240 can make the target surface 100 partially suspended, so as to be used for the target surface 100 to slide in and out along the first guide groove. During the sliding in process, the second notch 240 forms an escape space for the handheld target surface 100 to slide in along the first guide groove, so as to facilitate pushing the target surface 100 until the corner 115 abuts against the limit portion 223; during the sliding out process, the second notch 240 enables the staff to hold the target surface 100 on both sides or one side in the second direction to clamp the target surface 100 and move it outward. When the movement is blocked, the staff can push the target surface 100 at the first notch 230 to facilitate the target surface 100 to slide out to the end away from the first notch 230.

[0034] The first ends 221 of the two guide members 220 are each provided with a second chamfer 225 so that the sliding entrance has a flared structure. Through the arrangement of the second chamfer 225 and the corner portion 115, the two corner portions 115 at one end of the target surface 100 can fall horizontally or vertically into the sliding entrance, thereby increasing the way in which the target surface 100 can be placed at the sliding entrance, thereby avoiding the collision between the end of the target surface 100 and the side wall of the target holder 200 and the guide member 220. The target holder 200 is also provided with a first groove, in which a first magnetic member 250 capable of magnetically attracting the target surface 100 is provided so that the target surface 100 is attached to the first plane 210. The first magnetic member 250 and a protective sheet 260 for closing the first groove can be arranged on the top and / or bottom of the target holder 200. The first magnetic member 250 can be made of a neodymium iron boron magnet, etc., and the protective sheet 260 can be made of a silicon wafer, as long as the above-mentioned purpose can be achieved. The first magnetic member 250 can provide a magnetic guiding force for the target surface 100 to be placed in the first plane 210 . At the same time, after the corner 115 of the target surface 100 slides into the position of the limiting portion 223 of the target holder 200 , the first magnetic member 250 can keep the target surface 100 in the target holder 200 and prevent it from sliding out.

[0035] In some embodiments, both side portions of the target holder 200 are recessed to form a pick-up and placement position 270 to facilitate the staff to transfer the target holder 200. The tops of the two guide members 220 each have a second plane 224, which is parallel to the first plane 210, for stacking the target holders 200 and preventing the target surface 100 placed on the first plane 210 from being squeezed.

[0036] In one embodiment, the target holder 200 is provided with a third through hole 211 and a fourth through hole 212. The third through hole 211 can be assembled with the third positioning piece 312 on the sample target groove 300, and the fourth through hole 212 can be assembled with the fourth positioning piece 313 on the sample target groove 300. The number of the third through holes 211 and the fourth through holes 212 can be set according to actual needs. Taking two groups of third through holes 211 and two groups of fourth through holes 212 as an example, the third through holes 211 and the fourth through holes 212 are opened on the first plane 210 and pass through the target holder 200. One third through hole 211 and one fourth through hole 212 serve as a group of positioning structures. For example, when a group of positioning structures are assembled with the third positioning piece 312 and the fourth positioning piece 313 on the sample target groove 300, a group of target point units in the target surface 100 placed on the target holder 200 can be realized as target points. The point unit is detected, and then the group of positioning structures is removed, and another group of positioning structures is assembled with the third positioning member 312 and the fourth positioning member 313 on the sample target groove 300, so that another group of target point units can be detected as the target target point units, and the cross-sectional shapes of the third through hole 211 and the fourth through hole 212, as well as the cross-sectional shapes of the third positioning member 312 and the fourth positioning member 313 can be set according to actual needs, so that the third positioning member 312 and the third through hole 211 can be adapted to each other, and the fourth positioning member 313 and the fourth through hole 212 can be adapted to each other.

[0037] Furthermore, the third through holes 211 and the fourth through holes 212 of the same group of positioning structures can be spaced apart along the first direction, and when there are two groups of positioning structures, the two third through holes 211 can be centrally symmetrically arranged, and the two fourth through holes 212 can be centrally symmetrically arranged; the two third through holes 211 can also be spaced apart along the target unit arrangement direction, and the two fourth through holes 212 can be spaced apart along the target unit arrangement direction. In a feasible scheme, the third positioning member 312 and the fourth positioning member 313 both adopt a conical body, one of the third through hole 211 and the fourth through hole 212 adopts a circular through hole adapted to the conical body, and the other adopts an elliptical through hole adapted to the conical body, the sample target plate is axially positioned through the circular through hole, and the planar movement of the sample target plate is further restricted through the elliptical through hole, and at the same time, the elliptical through hole facilitates the matching process between the sample target plate and the sample target groove 300.

[0038] The upper surface of the target surface 100 also includes a second identification mark, which is used to identify different target surfaces 100 and / or different target units and / or different targets 111 and / or sample information on different target points 111, wherein the second identification mark includes a column number identification code 113, a position identification code 114, a column number identification label 116, a barcode area 117, and a target plate number 118, and the target plate number 118 and the barcode area 117 are respectively used for identification and scanning of the identification device to distinguish different target surfaces 100; the column number identification label 116 corresponds to the target unit one by one, and is used to mark the column number of the target unit, that is, to distinguish different target units on the same target surface 100; the column number identification code 113 is located at one end of the target unit in the first direction, and is used to assist in distinguishing different target units on the same target surface 100; the position identification code 114 is located at one end of the target unit in the first direction, and is used to assist in distinguishing different target units on the same target surface 100; The identification code 114 is set at one end of the target 111 in the first direction, and is used to distinguish different targets 111 on the same target unit, so that different or the same samples set on different targets 111 can be identified. After the camera recognizes the column number identification code 113, it automatically injects the sample and records the column number. The position identification codes 114 corresponding to the targets 111 in each column can be arranged starting from 1, for example, 1, 2, 3...12. The position identification codes 114 corresponding to the targets 111 in each column can also be set differently. For example, the position identification codes 114 on the first group of target units are 1, 2, 3...12 in sequence, and the position identification codes 114 on the second group of target units are set to 13, 14, 15...24 in sequence. The camera can perform dual authentication of the target 111 sites to ensure the accuracy of sample recording and collection.

[0039] The present application also provides a sample target slot 300, which is arranged in a mass spectrometer and is used to carry the above-mentioned sample target plate. The sample target slot 300 is provided with at least two mounting positions, and correspondingly, at least two groups of target units are provided on the sample target plate. When the sample target plate is installed to different mounting positions in the sample target slot 300, different target units become target target units in turn, and the two mounting positions can be partially overlapped, so that the sample target plate can be translated or rotated or both translated and rotated and then placed at different positions on the sample target slot 300, so that different target units are used as target target units for subsequent detection.

[0040] For example, the sample target slot 300 is provided with two mounting positions, and one surface of the target surface 100 is provided with four groups of target units (group A target unit, group B target unit, group C target unit, and group D target unit). First, the target surface 100 with the target holder 200 is placed on the first mounting position of the sample target slot 300, and the group A target unit is at the M position as the target target unit for subsequent detection. Then, the sample target plate is horizontally rotated 180° and then placed in the first mounting position so that the group B target unit, which is symmetrical with the center of the group A target unit, is located at the M position. The point unit is at the M position as the target target point unit for subsequent detection, and then the sample target plate is translated to the second installation position of the sample target groove 300 so that the D group of target point units are at the M position as the target target unit for subsequent detection, and finally the sample target plate is horizontally rotated 180° and continued to be placed in the second installation position of the sample target groove 300 so that the C group of target point units that are symmetrical with the center of the D group of target point units are at the M position as the target target unit for subsequent detection, in this way, the detection of four groups of target point units is completed in sequence.

[0041] When the sample target slot 300 is provided with two mounting positions, and the target surface 100 is provided with only two groups of target units (group A target units and group B target units), the target surface 100 with the target holder 200 can be placed on the first mounting position of the sample target slot 300 with the group A target units at the M position as the target target units for subsequent detection, and then the target surface 100 with the target holder 200 can be translated to the second mounting position of the sample target slot 300 with the group B target units at the M position as the target target units for subsequent detection.

[0042] In addition, the sample target groove 300 is provided with a second groove 310, and a pick-up and placement accommodating groove 320 extending to both sides of the second groove 310, and the pick-up and placement accommodating groove 320 is used for picking up and placing the target holder 200; the bottom surface of the second groove 310 is provided with a first protrusion 311, the third positioning member 312 and the fourth positioning member 313, the bottom of the target holder 200 is provided with a third plane, and a plurality of positioning grooves 280 of the same depth are opened on the third plane, the first protrusion 311 is adapted to the positioning groove 280 and corresponds one to one, the top of the first protrusion 311 is a plane structure, and all the plane structures are coplanar, which is convenient for the stable placement of the target holder 200, and at the same time, a gap can be created between the third plane and the bottom surface of the second groove 310, thereby avoiding the situation where the third plane and the second groove 310 cannot fit together due to accidental contact with foreign objects. A third groove is also provided on the bottom surface of the second groove 310, and a second magnetic member 330 is provided in the third groove. The second magnetic member 330 can be magnetically attracted to the first magnetic member 250 in the target holder 200 to limit the axial separation of the sample target plate or the target holder 200 from the planar structure, thereby improving the stability of the target holder 200 after being placed in the second groove 310.

[0043] The present application also provides a mass spectrometer, including the above-mentioned sample target slot 300, which also has all the beneficial effects of the above-mentioned sample target slot 300. In addition, the mass spectrometer also includes a motion mechanism 500 that can drive the sample target slot 300 to move along the first direction and the perpendicular XY direction. Driven by the motion mechanism 500, the sample target slot 300 separates from the cover plate 400 and enters the interior of the vacuum chamber for sample identification. The sample target slot 300 is provided with a target avoidance position 340 at the injection end, which can avoid interference with the cover plate 400 during the target in and out movement, and smoothly complete the injection movement.

[0044] It should be noted that, in this specification, relational terms such as first and second are merely used to distinguish one entity from other entities, but do not necessarily require or imply any actual relationship or order between these entities.

[0045] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0046] The principles and implementation methods of the present invention are described in this article using specific examples. The description of the above embodiments is only used to help understand the method and core ideas of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made to the present invention without departing from the principles of the present invention, and these improvements and modifications also fall within the scope of protection of the present invention.

Claims

1. A sample target plate, which is used to carry a sample and is configured to be installed in cooperation with a sample target slot of a mass spectrometer to achieve mass spectrometry detection of the sample, characterized in that: The sample target plate comprises a target holder and a target surface; At least two groups of target point units are arranged on the upper surface of the target surface, the target holder is provided with a first plane, the first plane is used to carry the target surface, and the sample target plate is installed in cooperation with the sample target slot of the mass spectrometer through the target holder; The target point unit includes a plurality of targets sequentially arranged along a first direction, and the target points are used to carry the sample; when the sample target plate is mounted to the sample target slot, the target point unit that can realize at least part of the target points sequentially being located at the detection position of the mass spectrometer as the sample target slot moves is the target target point unit; The target surface is installed in cooperation with the target holder in at least two orientations; and / or the target holder is installed in cooperation with the sample target slot in at least two orientations; when the target surface and / or the target holder changes to different orientations and is installed in the sample target slot, the different target point units become the target target point units in turn.

2. The sample target plate according to claim 1, characterized in that: The target holder is provided with a sliding groove for the target surface to slide into, a sliding entrance is provided at one end of the sliding groove in the sliding direction, and a limiting portion is provided at the other end of the sliding groove in the sliding direction, and the limiting portion is used to abut against the corner of the target surface to limit the sliding distance of the target surface.

3. The sample target plate according to claim 2, characterized in that: The target holder is provided with a third through hole and a fourth through hole. The third through hole can be assembled with the third positioning piece on the sample target groove, and the fourth through hole can be assembled with the fourth positioning piece on the sample target groove.

4. The sample target plate according to claim 2, characterized in that: The upper surface of the target surface also includes a second identification mark, which is used to identify different target surfaces and / or different target point units and / or different target points and / or sample information on different target points.

5. The sample target plate according to any one of claims 1 to 4, characterized in that: The target point units are provided in two groups, and the two groups of target point units are arranged in parallel on the upper surface of the target surface; When the sample target plate is mounted to the sample target slot, one group of the target point units is a target target point unit; When the target holder is horizontally rotated 180° and installed in the sample target groove, or the target surface is horizontally rotated 180° and installed in the target holder, another group of target point units is the target target point units.

6. The sample target plate according to any one of claims 1 to 4, characterized in that: The target point units are arranged in four groups, and the four groups of target point units are arranged in parallel on the upper surface of the target surface; When the sample target plate is mounted to the sample target slot, one group of the target point units is a target target point unit; When the target surface is horizontally rotated 180° with the target holder and installed in the sample target groove, the target holder is stationary and the target surface is horizontally rotated 180° and installed in the target holder, or the target holder is horizontally rotated 180° and installed in the sample target groove and the target surface is horizontally rotated 180° and installed in the target holder, the other three groups of target point units are target target point units in turn.

7. A sample target slot, which is arranged in a mass spectrometer and is used to carry the sample target plate according to any one of claims 1 to 6, characterized in that: The sample target slot is provided with at least two installation positions, and correspondingly, the sample target plate is provided with at least two groups of target point units. When the sample target plate is installed to different installation positions in the sample target slot, different target point units become the target target point units in turn.

8. A mass spectrometer, characterized in that Comprising the sample target groove as described in claim 7.

9. The mass spectrometer according to claim 8, characterized in that It also includes a motion mechanism capable of driving the sample target groove to move along a first direction.

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