Traditional Chinese medicine composition and application thereof as medicine for improving adipose tissue insulin resistance

Abstract

The invention belongs to the technical field of traditional Chinese medicine prescriptions, and particularly relates to a traditional Chinese medicine composition and application of the traditional Chinese medicine composition as a medicine for improving adipose tissue insulin resistance. The traditional Chinese medicine composition comprises 8-12 parts of radix stephaniae tetrandrae, 25-35 parts of radix astragali, 10-20 parts of rhizoma atractylodis macrocephalae stir-fried with bran, 8-10 parts of honey-fried licorice root, 10-20 parts of poria cocos, 5-15 parts of pogostemon cablin, 10-20 parts of codonopsis pilosula, 8-10 parts of cassia twig, 15-25 parts of pericarpium citri reticulatae and 8-12 parts of gynostemma pentaphylla. After a patient suffering from the adipose tissue insulin resistance takes the traditional Chinese medicine composition according to the medical advice, the effect of reducing the adipose tissue insulin resistance is achieved, the BMI and the waist-hip ratio of the patient suffering from the adipose tissue insulin resistance can be reduced, and the sensitivity of the body to insulin is further improved; the blood sugar and the blood fat of a patient suffering from adipose tissue insulin can be reduced; when the traditional Chinese medicine composition is applied to a patient suffering from adipose tissue insulin resistance, the metabolic health of the body can be improved, and the adipose tissue insulin resistance index can be reduced, so that the morbidity of chronic diseases such as diabetes, hypertension, dyslipidemia and cardiovascular diseases is reduced.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine prescriptions, and particularly relates to a traditional Chinese medicine composition and its application as a drug for improving insulin resistance in adipose tissue. Background Art

[0002] Insulin resistance refers to a significant weakening of the biological effects of insulin in promoting glucose uptake and utilization, etc. Specifically, it is manifested as obstacles in the utilization of glucose by peripheral tissues, especially muscle and adipose tissues, that is, the target organs of insulin action (such as the liver, muscle, adipose tissue, etc.) have a biological response to a certain amount of insulin lower than the normal expected level, thereby resulting in hyperinsulinemia, causing dyslipidemia, leading to vascular endothelial dysfunction, increasing the risk of hypertension, and thus greatly increasing the incidence of cardiovascular diseases, such as coronary heart disease, myocardial infarction, stroke, etc. And adipose tissue insulin resistance refers to the specific occurrence of this disorder in adipose tissue, which is a common type of insulin resistance.

[0003] The resistance of adipocytes to insulin increases, which will increase the uptake of glucose by adipocytes, and then synthesize more fat. Therefore, fat synthesis will increase. On the other hand, due to insulin resistance, adipose tissue resists the effect of insulin in inhibiting lipolysis, resulting in increased enzyme activity of lipolysis, thereby promoting lipolysis. Although lipolysis increases, due to the overall metabolic disorder caused by insulin resistance, fat synthesis usually still exceeds lipolysis, leading to the accumulation of fat in the body, forming obesity and cardiovascular and cerebrovascular diseases, etc. Therefore, there is an urgent need for a traditional Chinese medicine composition to improve insulin resistance in adipose tissue. Summary of the Invention

[0004] In view of this, the present invention provides a traditional Chinese medicine composition and its application as a drug for improving insulin resistance in adipose tissue to solve the technical problem of improving insulin resistance in adipose tissue.

[0005] To achieve the above object, the present application adopts the following scheme:

[0006] A traditional Chinese medicine composition, comprising the following components:

[0007] Stephania tetrandra 8 - 12 parts, Astragalus membranaceus 25 - 35 parts, Atractylodes macrocephala Koidz. stir-fried with bran 10 - 20 parts, Glycyrrhiza uralensis Fisch. preparata 8 - 10 parts, Poria cocos 10 - 20 parts, Pogostemon cablin 5 - 15 parts, Codonopsis pilosula 10 - 20 parts, Cinnamomum cassia Presl 8 - 10 parts, Citrus reticulata Blanco 15 - 25 parts, Gynostemma pentaphyllum 8 - 12 parts, Alisma orientale 8 - 12 parts, and this traditional Chinese medicine composition can increase the sensitivity of the body to insulin.

[0008] Preferably, it includes the following components: 10 parts of Stephania tetrandra, 30 parts of Astragalus membranaceus, 15 parts of stir-fried Atractylodes macrocephala with bran, 9 parts of roasted Glycyrrhiza uralensis, 15 parts of Poria cocos, 12 parts of Pogostemon cablin, 15 parts of Codonopsis pilosula, 9 parts of Cinnamomum cassia, 20 parts of Citrus reticulata Blanco, 10 parts of Gynostemma pentaphyllum, 10 parts of Alisma orientale.

[0009] Furthermore, the traditional Chinese medicine composition includes pharmaceutically acceptable pharmaceutical excipients in traditional Chinese medicine pharmacy and is prepared into drug dosage forms applicable to clinical use, including tablets, oral liquids, pills, granules, capsules, injections, sustained-release and controlled-release preparations.

[0010] Furthermore, the application of the above traditional Chinese medicine composition as a drug for improving insulin resistance in adipose tissue is also provided.

[0011] In the above traditional Chinese medicine composition and its application as a drug for improving insulin resistance in adipose tissue, 8 - 12 parts of Stephania tetrandra, 25 - 35 parts of Astragalus membranaceus, 10 - 20 parts of stir-fried Atractylodes macrocephala with bran, 8 - 10 parts of roasted Glycyrrhiza uralensis, 10 - 20 parts of Poria cocos, 5 - 15 parts of Pogostemon cablin, 10 - 20 parts of Codonopsis pilosula, 8 - 10 parts of Cinnamomum cassia, 15 - 25 parts of Citrus reticulata Blanco, 8 - 12 parts of Gynostemma pentaphyllum, and 8 - 12 parts of Alisma orientale are used to form the traditional Chinese medicine composition. This traditional Chinese medicine composition can increase the sensitivity of the body to insulin, that is, improve the action of insulin in adipose tissue. After patients with adipose tissue insulin resistance take this traditional Chinese medicine composition according to the doctor's advice, it has the effect of reducing the insulin resistance index, and can also reduce the BMI and waist-to-hip ratio of patients with adipose tissue insulin resistance. As the waist-to-hip ratio of patients decreases, the sensitivity of the body to insulin is further improved; it can also reduce the blood sugar and blood lipids of patients with adipose tissue insulin, thereby helping to reduce the burden on pancreatic islet β cells, giving them more opportunities to rest and recover, and contributing to the process of insulin signal transduction and glucose transport; when this traditional Chinese medicine composition is applied to patients with adipose tissue insulin resistance, it can improve the metabolic health of the body, reduce the adipose tissue insulin resistance index, and thus reduce the prevalence of chronic diseases such as diabetes, hypertension, dyslipidemia, and cardiovascular diseases.

[0012] In addition, the traditional Chinese medicine composition provided by the present invention can also reduce the inflammatory factors in patients with adipose tissue insulin resistance. Description of the Drawings

[0013] Figure 1 It is a bar chart of inflammatory factor (TNF-α) in the test examples of this application.

[0014] Figure 2 It is a bar chart of inflammatory factor (IL-6) in the test examples of this application.

[0015] Figure 3 It is a bar chart of inflammatory factor (MCP-1mRNA) in the test examples of this application. Detailed Embodiments

[0016] To make the objectives and technical solutions of the present invention clearer and more understandable, the content of the present invention will be further described in detail through experiments. However, it should not be understood that the scope of the above-mentioned subject matter of the present invention is limited to the following experiments only. Any corresponding substitution or modification made based on the common general knowledge and customary means in the art without departing from the above-mentioned technical solutions of the present invention is included in the present invention.

[0017] The following further illustrates the technical solutions and technical effects of the present invention through specific experimental examples. It should be noted that the inventor has carried out relevant pharmacodynamic experimental studies to prove the efficacy of the traditional Chinese medicine composition of the present invention in improving insulin resistance in adipose tissue. It should be noted that the following experimental studies are all carried out on the basis of proving the drug safety, and the administration doses in the experimental studies are all within the safe dose range. The drugs selected in the following pharmacodynamic tests are the drugs obtained from the representative formula of the present invention and its preparation method; the inventor has also carried out pharmacodynamic experiments on other drugs, and the experimental results show the same or similar effects. However, due to space limitations, they are not listed one by one here.

[0018] 1. Drug materials

[0019] Metformin tablets (China Resources Double-Crane Pharmaceutical Co., Ltd., 0.5 g / tablet);

[0020] A decoction prepared by decocting 10 g of Stephania tetrandra, 30 g of Astragalus membranaceus, 15 g of stir-fried Atractylodes macrocephala with bran, 9 g of roasted Glycyrrhiza uralensis, 15 g of Poria cocos, 12 g of Pogostemon cablin, 15 g of Codonopsis pilosula, 9 g of Cinnamomum cassia, 20 g of Citrus reticulata Blanco, 10 g of Gynostemma pentaphyllum, and 10 g of Alisma orientale (decocted in the traditional Chinese medicine pharmacy of Yinchuan Traditional Chinese Medicine Hospital).

[0021] 2. Related technical solutions

[0022] 1) Collect patients with adipose tissue insulin resistance

[0023] The diagnostic criteria for patients with adipose tissue insulin are as follows:

[0024] (1) Waist circumference: for men, waist circumference ≥ 90 cm; for women, waist circumference ≥ 85 cm;

[0025] (2) Overweight and obesity degree: BMI ≥ 28 kg / m 2 (weight (kg) / [height (m)]2), obesity degree ≥ 20% [(actual weight - standard weight) / standard weight × 100%] is obesity, standard weight (kg) = height (cm) - 105, waist-hip ratio (WHR) = waist circumference / hip circumference (waist circumference: the perimeter between the lowest rib point and the upper edge of the iliac crest, measured with a flexible ruler at the end of exhalation and before the start of inhalation. Hip circumference: the horizontal perimeter at the most prominent part of the buttocks, measured with a flexible ruler), for adult men ≥ 0.9, for women ≥ 0.85, and at the same time meeting BMI ≥ 25 kg / m2 、If two of the following conditions are met: obesity percentage (%) ≥ 20%, waist-to-hip ratio ≥ 0.9 for adult males and ≥ 0.85 for adult females, overweight or obesity can be diagnosed;

[0026] (3) Blood glucose and insulin levels: By detecting fasting blood glucose and insulin levels, the insulin resistance index (such as HOMA-IR) can be calculated. If this index increases, it indicates possible insulin resistance. For the oral glucose tolerance test, after ingesting a certain amount of glucose, blood glucose and insulin levels are measured at different time points; if blood glucose increases while insulin secretion is excessive, it may also indicate the presence of insulin resistance;

[0027] (4) The main clinical manifestation is acanthosis nigricans: It is commonly seen in skin folds such as the neck, armpits, and groin, manifested as thickened and darkened skin, showing a velvet-like change, which is closely related to insulin resistance;

[0028] (5) Polycystic ovary syndrome (PCOS): In women, PCOS patients often have insulin resistance and may be accompanied by manifestations such as obesity, hirsutism, and acne;

[0029] If a patient meets any three of the above diagnostic criteria, the patient can be diagnosed as an adipose tissue insulin patient.

[0030] According to the above diagnostic criteria for adipose tissue insulin patients, 80 patients diagnosed as adipose tissue insulin patients were collected, who came from the outpatient and inpatient departments of the Endocrinology Department of Yinchuan Traditional Chinese Medicine Hospital from April 2022 to July 2023. The patients were randomly divided into a control group (n = 40 cases) and an experimental group (n = 40 cases), and there was no case dropout in both groups. Among them, there were 22 males and 18 females in the experimental group, with an age of (46.67 ± 14) years and a disease course of (4.66 ± 4.44) years, and a BMI of 27.38 ± 1.03 kg / m 2 , 24 males and 16 females in the control group, with an age of (44.28 ± 12.95) years, a disease course of (3.39 ± 2.4) years, and a BMI of 27.67 ± 0.55 kg / m2; There were no significant differences in the gender, age, disease course, and BMI data between the two groups of patients (P > 0.05), and they were comparable.

[0031] 2) Treatment methods

[0032] (1) Basic treatment: Both groups received health education and instructions regarding diet and exercise related to adipose tissue insulin resistance. Health education: Informed the patients about the concept, occurrence, and development of adipose tissue insulin resistance, informed that adipose tissue insulin resistance could increase the incidence of obesity and other related complications, and exhorted the patients and their families to actively implement health management. Informed the patients that they should actively monitor blood glucose and lipid changes to adjust the treatment plan in a timely manner. Reasonable diet: Maintain a balanced daily intake of food nutrients, and the intake of energy substances should be in proportion. The intake ratios of protein, fat, and carbohydrates can be controlled at 15%, 25%, and 60% per day, and other nutrients such as vitamins should be supplemented reasonably. Smoking, drinking, and other health-impairing behaviors are strictly prohibited. Maintain exercise: In addition to daily activities, supplemented with appropriate exercise, exercise 3 - 4 days a week, with moderate exercise intensity, and try to ensure that the exercise heart rate is 50% - 70% of the maximum heart rate (220 - age), this method reduces insulin resistance.

[0033] (2) Drug treatment

[0034] The control group was given conventional Western medicine treatment (metformin), and the experimental group, on the basis of conventional Western medicine treatment (metformin tablets), was additionally administered the decoction prepared by decocting the traditional Chinese medicine composition provided by the present invention. 12 weeks is a treatment course, that is, 3 months. Metformin tablets, 1 tablet each time, 2 times a day, orally before breakfast and dinner; the above-mentioned decoction, 1 dose per day, taken in two divided doses in the morning and evening.

[0035] (3) Data detection

[0036] After one treatment course, the main observations were the changes in the patients' insulin resistance index (HOMA-IR), body mass index (BMI), and waist-to-hip ratio (WHR); the secondary observations were: fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), inflammatory factors (IL-6, TNF-α). SPSS 25.0 software was used for data statistical analysis. Measurement data were expressed as mean ± standard deviation (x ± s). All the collected data were first subjected to a normality test. If they met normality and homogeneity of variance, paired t-tests were used for within-group comparison before and after treatment, and two independent sample t-tests were used for between-group comparison; if not, rank sum tests were used. Count data were analyzed using chi-square tests. Rank sum tests were used for ranked data. P < 0.05 indicated that the difference was statistically significant.

[0037] The TCM syndrome scores were evaluated according to the TCM syndrome efficacy evaluation criteria: If the TCM clinical symptoms basically disappeared and the syndrome score decreased by ≥95%, it was defined as clinical cure; if most of the TCM clinical symptoms disappeared or weakened and the syndrome score decreased by ≥70%, it was defined as marked effect; if the TCM clinical symptoms were significantly weakened and the syndrome score decreased by ≥30%, it was defined as effective; if the TCM clinical symptoms had no obvious improvement and the syndrome score decreased by <30%, it was defined as ineffective.

[0038] The calculation formula (Nimodipine method) was: TCM syndrome score = (score before treatment - score after treatment) / score before treatment × 100%.

[0039] 3. Experimental results

[0040] After treating the above two groups of patients with different treatment methods for one course of treatment (3 months), the main observation indicators of the two groups of patients before and after treatment were detected and statistically analyzed, namely, the insulin resistance index (HOMA-IR), body mass index, and waist-to-hip ratio were detected and statistically analyzed respectively.

[0041] 1) Comparison of the insulin resistance index (HOMA-IR) of adipose tissue in the two groups of patients before and after treatment, as shown in Table 1:

[0042] Table 1 Comparison of HOMA-IR between the two groups (x±s)

[0043]

[0044]

[0045] It can be seen from the data in Table 1 above that after treatment, the HOMA-IR of the patients in the experimental group decreased significantly compared with that of the control group (P < 0.01). Generally, the normal range of the insulin resistance index of adipose tissue is less than 2.69. If the calculation result is greater than or equal to 2.69 ± 0.57, it may indicate the existence of adipose tissue insulin resistance. The insulin resistance index of adipose tissue after treatment in the control group was close to 2.69, and there was still a risk of having adipose tissue insulin resistance. However, after treatment in the experimental group, the insulin resistance index of adipose tissue in the patients decreased to 2.28 ± 0.47*, significantly lower than 2.66, and there was no adipose tissue insulin resistance, indicating that the treatment method of the experimental group can increase the sensitivity of the body to insulin, that is, the effect of insulin in adipose tissue is improved.

[0046] 2) Comparison of the body mass index and waist-to-hip ratio of the two groups of patients before and after treatment, as shown in Table 2:

[0047] Table 2 Comparison of BMI and waist-to-hip ratio between the two groups (x±s)

[0048]

[0049] Note: Compared with the post-treatment of this group, *P < 0.05; compared with the post-treatment of the control group, ※P < 0.05.

[0050] A decrease in BMI generally means a reduction in body weight, with most of the reduction being adipose tissue, which is the main site for secreting some factors that cause the body to be resistant to insulin. Therefore, reducing adipose tissue helps to reduce insulin resistance in adipose tissue. Moreover, as BMI decreases, the metabolic health of the body improves, including the optimization of indicators such as blood glucose, blood lipids, and blood pressure. A decrease in the waist-to-hip ratio means a reduction in abdominal fat and a relative increase in hip fat, which reflects a change in fat distribution. Abdominal fat (especially visceral fat) is more closely related to insulin resistance. Therefore, its reduction helps to reduce insulin resistance, and as the waist-to-hip ratio decreases, the sensitivity of the body to insulin increases. As reflected by the data in Table 2 above, after respectively giving diet and exercise guidance and regular basic treatment for reducing blood sugar, blood pressure, and blood lipids to the two groups of patients with adipose tissue insulin resistance, the BMI and waist-to-hip ratio of both groups of patients decreased compared with before treatment, and the difference was statistically significant (P < 0.05). The decrease in BMI and waist-to-hip ratio of the experimental group was more obvious, and it was overall better than the control group (P < 0.05).

[0051] After treating the above two groups of patients with different treatment methods for one course of treatment (3 months), the secondary observation indicators of the two groups of patients before and after treatment were detected and statistically analyzed, that is, the blood glucose level, blood lipid level, and inflammatory factors (IL-6, TNF-α) were detected and statistically analyzed respectively.

[0052] 3) Comparison of the blood glucose levels of the two groups of patients before and after treatment is shown in Table 3:

[0053] Table 3 Comparison of blood glucose levels between the two groups (x±s)

[0054]

[0055] Note: Compared with the post-treatment of this group, *P < 0.05; compared with the post-treatment of the control group, ※P < 0.05.

[0056] As shown by the data in Table 3 above, after respectively giving diet and exercise guidance and regular basic treatment for reducing blood sugar, blood pressure, and blood lipids to the two groups of patients with adipose tissue insulin resistance, comparing the three indicators of fasting blood glucose, 2-hour postprandial blood glucose, and glycosylated hemoglobin ratio before and after treatment as the criteria for evaluating the blood glucose control of patients, the overall blood glucose decrease in the experimental group was better than that in the control group (P < 0.05). This shows that the treatment method adopted by the experimental group can reduce the body's demand for insulin, help reduce the burden on pancreatic islet β cells, give them more opportunities to rest and recover, and help the process of insulin signal transduction and glucose transport, enhancing the improvement of insulin sensitivity in adipose tissue compared with the control group.

[0057] 4) Comparison of blood lipid levels in the two groups of patients before and after treatment is shown in Table 4 as follows:

[0058] Table 4 Comparison of blood lipid levels in the two groups (x±s)

[0059]

[0060] Note: Compared with after treatment in this group, *P < 0.05; compared with after treatment in the control group, ※P < 0.05

[0061] Since the hyperlipidemia state in patients with adipose tissue insulin resistance can lead to excessive lipid deposition in adipocytes, which in turn interferes with the normal conduction of the insulin signaling pathway. However, the blood lipid levels (TG, TC, LDL) in the two groups of patients after treatment in Table 4 above all decreased (P < 0.05). Compared with the control group, the decreases in TG, TC, and LDL in the experimental group were more obvious (P < 0.05), indicating that the treatment method in the experimental group can further reduce the degree of adipose tissue insulin resistance compared with the control group.

[0062] 5) Comparison of traditional Chinese medicine treatment efficacy evaluation in the two groups of patients before and after treatment is shown in Table 5 as follows:

[0063] Table 5 Traditional Chinese medicine treatment efficacy evaluation in the two groups

[0064]

[0065] The data in Table 5 above show that after a 12-week observation period, the total effective rate of the experimental group was 75%, and that of the control group was 32.5%. The difference was statistically significant (P < 0.001), indicating that the treatment method used in the control group, that is, after adipose tissue insulin resistance patients took the above-mentioned decoction, could improve adipose tissue insulin resistance and significantly improve the clinical symptoms of patients.

[0066] 6) Comparison of inflammatory factors (IL-6, TNF-α) in the two groups of patients before and after treatment is shown in Table 6 as follows:

[0067] Table 6 Comparison of IL-6 and TNF-α in the two groups (x±s)

[0068]

[0069] Note: Compared with after treatment in this group, *P < 0.05; compared with after treatment in the control group, ※P < 0.01

[0070] As can be seen from the data in Table 6 above, after one course of treatment, the inflammatory factors (IL-6, TNF-α) in both groups of patients decreased compared with those before treatment (P < 0.05). Compared with the control group, the decrease in the experimental group was more significant (P < 0.01), indicating that the treatment method used in the experimental group not only improved insulin resistance in adipose tissue but also reduced inflammatory factors.

[0071] In summary, when the traditional Chinese medicine composition provided by the present invention is used as a drug for improving insulin resistance in adipose tissue, it can increase the sensitivity of the body to insulin, that is, improve the effect of insulin in adipose tissue, thereby reducing the insulin resistance index of patients with adipose tissue insulin resistance; and it can reduce the BMI and waist-to-hip ratio of patients with adipose tissue insulin resistance. As the waist-to-hip ratio of patients decreases, the sensitivity of the body to insulin is further improved; it can also reduce the blood sugar and blood lipids of patients with adipose tissue insulin, which helps to reduce the burden on pancreatic islet β cells, giving them more opportunities to rest and recover, and contributing to the process of insulin signal transduction and glucose transport; when this traditional Chinese medicine composition is applied to patients with adipose tissue insulin resistance, it can improve the metabolic health of the body, reduce the adipose tissue insulin resistance index, and thus reduce the prevalence of chronic diseases such as diabetes, hypertension, dyslipidemia, and cardiovascular diseases.

[0072] Furthermore, the following in vitro experiments were conducted to verify that the working solution in the experimental group could reduce adipose tissue inflammatory factors in the above test examples.

[0073] Mix 10 g of Stephania tetrandra, 30 g of Astragalus membranaceus, 15 g of stir-fried Atractylodes macrocephala with bran, 9 g of roasted Glycyrrhiza uralensis, 15 g of Poria cocos, 12 g of Pogostemon cablin, 15 g of Codonopsis pilosula, 9 g of Cinnamomum cassia, 20 g of Citrus reticulata Blanco, 10 g of Gynostemma pentaphyllum, and 10 g of Alisma orientale. After ultrafine grinding (400 mesh), weigh 1 mg of the powder and dissolve it in 2 ml of sterile phosphate (PBS) solution. Sonicate it at 60 °C for 2 h with supersonic waves to prepare a stock solution of 500 μg / ml. In the experiment, take 200 μl of the stock solution and add it to 2 ml of cell culture medium to dilute it into a working solution of 100 μg / ml. The results of the preliminary pre-experiment showed that the working solution had no significant effect on the proliferation of 3T3-L1 preadipocytes within the concentration range of 20 - 100 μg / ml (P > 0.05). The working solution with a concentration of 100 μg / ml was selected for the subsequent experiment in the laboratory.

[0074] After the experiment, the real-time PCR method was used to detect the expression of the main inflammatory factors TNF-α, IL-6, and MCP-1 mRNA in adipocytes, and the results are as Figures 1 to 3 and Table 7 shows:

[0075] Table 7 Effects of the working solution on the expression of TNF-α, IL-6, and MCP-1 mRNA

[0076]

[0077] Note: Compared with the control group, △P < 0.05, △△P < 0.005

[0078] From Figures 1 to 3 Combined with the data in Table 7 above, it shows that the working fluid (100 μg / ml) can inhibit the expression of TNF-α and MCP-1 mRNA in adipocytes (P < 0.005, P < 0.05) (n = 6), and there is no statistical significance in the expression of IL-6 mRNA compared with the control group (P > 0.05) (n = 6). That is to say, when the traditional Chinese medicine composition provided by the present invention and its application as a drug for improving insulin resistance in adipose tissue are used, the level of inflammatory factors of insulin resistance in adipose tissue can also be reduced.

[0079] As described above, it is only the specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should be covered within the protection scope of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: Includes the following components: The Chinese medicine composition comprises 8-12 parts of Stephania tetrandra, 25-35 parts of Astragalus, 10-20 parts of Rhizoma Atractylodis Macrocephalae with bran, 8-10 parts of Radix Glycyrrhizae, 10-20 parts of Poria, 5-15 parts of Patchouli, 10-20 parts of Codonopsis pilosula, 8-10 parts of Cinnamon twig, 15-25 parts of Citrus reticulatae, 8-12 parts of Gynostemma pentaphyllum and 8-12 parts of Rhizoma Alismatis. The Chinese medicine composition can increase the sensitivity of an organism to insulin.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following components: 10 parts of Stephania tetrandra, 30 parts of Radix Astragali, 15 parts of Rhizoma Atractylodis Macrocephalae with bran, 9 parts of Radix Glycyrrhizae, 15 parts of Poria, 12 parts of Poria, 15 parts of Codonopsis pilosula, 9 parts of Cinnamon twig, 20 parts of Citrus reticulatae, 10 parts of Gynostemma pentaphyllum and 10 parts of Rhizoma Alismatis.

3. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition comprises pharmaceutical excipients acceptable in Chinese medicine pharmacy and is prepared into drug dosage forms suitable for clinical use, including tablets, oral liquids, pills, granules, capsules, injections, and sustained-release preparations.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 as a drug for improving insulin resistance in adipose tissue.

Images