Traditional Chinese medicine composition and application thereof in preparation of medicine for preventing and treating alcoholic gastritis

Abstract

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for preventing and treating alcoholic gastritis. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 15 to 20 parts of radix puerariae, 15 to 20 parts of rhizoma phragmitis, 15 to 20 parts of rhizoma imperatae, 10 to 15 parts of dried herba dendrobii, 6 to 10 parts of fructus citri sarcodactylis, 10 to 15 parts of radix codonopsis, 10 to 15 parts of herba pogostemonis, 10 to 15 parts of herba lophatheri, 6 to 10 parts of herb tea and 10 to 15 parts of pericarpium citri reticulatae. The traditional Chinese medicine is mainly used for clearing heat and promoting diuresis, is supplemented by nourishing yin and regulating qi, not only relieves the symptoms (headache, thirst and nausea) of alcoholism, but also protects the root of spleen, stomach, liver and kidney, and is integrally synergetic to take both symptoms and root causes into consideration; the formula embodies the comprehensive thought of clearing, benefiting, tonifying and regulating in the traditional Chinese medicine, not only conforms to the traditional anti-alcohol theory, but also considers the modern metabolic mechanism, and has higher clinical practical value.

Description

Technical Field

[0001] The present invention belongs to the technical field of biomedicine, and particularly relates to a traditional Chinese medicine composition and its application in the preparation of drugs for preventing and treating alcoholic gastritis. Background Art

[0002] Alcoholic gastritis is mucosal erosion caused by excessive drinking. The main symptom is upper abdominal pain, and gastric bleeding may also occur, often accompanied by esophagitis. However, in the food culture of our country, drinking is often inevitable, so the situation of excessive drinking occurs from time to time.

[0003] In order to protect the gastric mucosa and reduce the harm caused by drinking, Chinese patent application with publication number CN113786429A discloses a red date extract for protecting the gastric mucosa, a preparation method, uses and a traditional Chinese medicine composition. This technology makes a fluid extract by extracting red date raw materials with water, or makes a semi-solid in the form of jujube paste by steaming red date raw materials in a water bath, or makes a semi-solid in the form of jujube paste by steaming red date raw materials under pressure. The obtained red date extract has a good effect on treating chronic gastritis (especially alcoholic gastritis).

[0004] Developing more formulae that can be used to prevent and treat alcoholic gastritis and providing more ways for drinkers to relieve physical discomfort caused by excessive drinking is a problem that needs to be solved currently. Summary of the Invention

[0005] The object of the present invention is to provide a traditional Chinese medicine composition. By mass fraction, the traditional Chinese medicine composition comprises the following raw medicinal materials: 15 - 20 parts of kudzu root, 15 - 20 parts of reed root, 15 - 20 parts of lanceolate leaf of imperata, 10 - 15 parts of dried dendrobium, 6 - 10 parts of fingered citron, 10 - 15 parts of pilose asiabell root, 10 - 15 parts of patchouli, 10 - 15 parts of lophatherum gracile, 6 - 10 parts of edible cold tea, and 10 - 15 parts of dried tangerine peel.

[0006] This formula embodies the comprehensive thinking of traditional Chinese medicine in "clearing heat, promoting diuresis, tonifying deficiency, and regulating functions". It not only conforms to the traditional theory of relieving alcohol intoxication but also takes into account modern metabolic mechanisms, having high clinical practical value. In the formula, both reed rhizome and cogongrass rhizome are good herbs for clearing heat and promoting fluid production, as well as diuresis and detoxification; reed rhizome, being cold in nature and attributing to the lung and stomach meridians, can clear heat and promote fluid production, remove vexation and quench thirst, especially good at clearing heat and toxins in the lung and stomach, and promoting alcohol metabolism; cogongrass rhizome, being sweet and cold, attributing to the lung, stomach, and bladder meridians, can cool blood and stop bleeding, promote diuresis and relieve stranguria, help alcohol excrete from urine, and relieve vexation and thirst after drinking, so they are used as the monarch herbs together. Kudzu root can relieve muscle fever and promote fluid production. Modern research has confirmed that it can accelerate alcohol decomposition and relieve symptoms such as headache and thirst; dendrobium, being sweet and slightly cold, can nourish yin and clear heat, promote the production of gastric fluid, repair the damage of alcohol to gastric yin, and improve dry mouth and throat; agastache can aromatically transform dampness, awaken the spleen and harmonize the stomach, relieve discomfort such as nausea and abdominal distension after drinking; lophatherum gracile, being sweet and bland for promoting diuresis and dampness elimination, clearing heat and removing vexation, helps the monarch herbs in diuresis and detoxification, and accelerates the metabolism of the liver, and they are used as the minister herbs together. Finger citron can soothe the liver, regulate qi, resolve phlegm, relieve the dredging of the liver after drinking, repair the spleen and stomach functions, and improve discomfort such as fullness and distension in the epigastrium; codonopsis pilosula, being sweet and neutral for replenishing qi, prevents the excessive consumption of vital qi by heat-clearing and dampness-drying herbs, and protects the qi of the spleen and stomach; herbal tea for relieving alcohol toxicity can clear heat and detoxify, promote digestion and resolve food stagnation, assist in relieving alcohol toxicity, relieve gastrointestinal heat accumulation after drinking, and protect the liver, and they are used as the assistant herbs together. Tangerine peel can regulate qi and harmonize the middle, guide the herbs into the spleen and stomach meridians, and enhance the synergistic effect of the whole formula, so it is used as the envoy herb.

[0007] Among them, the combination of reed rhizome, cogongrass rhizome, kudzu root, and dendrobium works together to achieve the effect of clearing heat and promoting fluid production. Aiming at the core pathogenesis of alcohol transforming into heat and injuring body fluid (dry mouth, vexation and thirst), it can clear heat and promote fluid production, and relieve the heat and toxins of alcohol; the combination of cogongrass rhizome and lophatherum gracile promotes diuresis and relieves stranguria, accelerates the excretion of alcohol and its metabolites (such as acetaldehyde) from urine, reduces the burden on the liver, and further protects the liver; the combination of agastache, tangerine peel, and finger citron aromatically transforms dampness, regulates qi and harmonizes the middle, and improves the syndrome of dampness obstructing the spleen and stomach after drinking (nausea, abdominal distension, loss of appetite); the combination of dendrobium and codonopsis pilosula nourishes yin and protects the stomach, replenishes qi and strengthens the healthy qi, preventing the excessive injury of vital qi by heat-clearing and dampness-drying herbs, and is suitable for the physical conditioning of long-term drinkers; the whole formula mainly focuses on clearing heat and promoting diuresis, supplemented by nourishing yin and regulating qi, relieving both the symptoms of alcohol toxicity (headache, thirst, nausea) and protecting the root of the spleen, stomach, liver, and kidney. The overall coordination takes both the symptoms and root causes into consideration.

[0008] Based on this, the present invention also provides the application of the above traditional Chinese medicine composition in the preparation of drugs for preventing and treating alcoholic gastritis.

[0009] The research of the present invention finds that the above traditional Chinese medicine composition can effectively prevent the occurrence of ethanol-induced gastric mucosal lesions or alleviate the symptoms of ethanol-induced gastric mucosal lesions, and has good curative effects in preventing and treating alcoholic gastritis.

[0010] The present invention also provides an anti-alcoholism tea, and the active ingredients of the anti-alcoholism tea at least include the water extract or decoction of the above traditional Chinese medicine composition.

[0011] Among them, the water extract is prepared by the following method:

[0012] (1) Add distilled water with a volume 10 times that of the said traditional Chinese medicine composition, and perform reflux extraction to obtain a filtrate.

[0013] Preferably, the reflux extraction is performed at least 2 times, with each time being at least 2 h.

[0014] (2) Combine all the filtrates, concentrate them, and then dry to obtain the water extract.

[0015] The decoction is prepared by the following method: Add water with a volume 8 - 12 times that of the said traditional Chinese medicine composition, and decoct over a slow fire for at least 2 h to obtain the decoction.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0017] In the traditional Chinese medicine composition of the present invention, Phragmites australis, Imperata cylindrica, Pueraria lobata, and Dendrobium officinale are combined in compatibility to achieve the effect of clearing heat and promoting fluid production together, aiming at the core pathogenesis of heat generated by alcohol damaging body fluid (dry mouth, polydipsia), and playing the role of clearing heat and promoting fluid production and relieving alcohol - derived heat toxin; Imperata cylindrica and Lophatherum gracile are combined in compatibility to promote diuresis and relieve stranguria, accelerating the excretion of alcohol and its metabolites (such as acetaldehyde) from urine, reducing the burden on the liver, and further protecting the liver; Agastache rugosa, Citrus reticulata Blanco, and Citrus medica L. var. sarcodactylis are combined in compatibility to aromatize dampness and regulate qi and harmonize the middle energizer, improving the syndrome of dampness - obstructing the spleen and stomach after drinking (nausea, abdominal distension, loss of appetite); Dendrobium officinale and Codonopsis pilosula are combined in compatibility to nourish yin and protect the stomach, replenish qi and strengthen the healthy qi, preventing the excessive damage to healthy qi by drugs for clearing heat and promoting diuresis, and being suitable for the physical conditioning of long - term drinkers; The whole formula mainly focuses on clearing heat and promoting diuresis, supplemented by nourishing yin and regulating qi, relieving both the symptoms of alcohol toxin (headache, thirst, nausea) and protecting the root of the spleen, stomach, liver, and kidney. The overall coordination takes both the symptoms and root causes into consideration; This formula embodies the comprehensive idea of "clearing, promoting diuresis, tonifying, and regulating" in traditional Chinese medicine, conforming to both the traditional theory of relieving alcohol and taking into account the modern metabolic mechanism, and having high clinical practical value. Description of the Drawings

[0018] Figure 1 This shows that the anti - alcoholism tea of the present invention relieves alcohol - induced gastric mucosal injury and down - regulates the gene expression levels of inflammatory factors;

[0019] Among them, Control represents the blank control group, Alcohol represents the alcohol model group, JJC - L, JJC - M, and JJC - H respectively represent the low, medium, and high dose groups of the anti - alcoholism tea, Relative expression of TNF - α / IL - 1β / IL - 6mRNA represents the relative mRNA expression levels of TNF - α, IL - 1β, or IL - 6, and the same applies hereinafter;

[0020] Figure 2 This shows that the anti - alcoholism tea of the present invention reduces the oxidative stress level of alcohol - induced gastritis;

[0021] Among them, NO / MDA / SOD / CAT release (ratio to control) respectively represents the release levels of NO, MDA, SOD, or CAT (relative to the blank control group);

[0022] Figure 3 This invention's hangover tea down-regulates the relative expression levels of HIF-1α, VEGF, and VEGFR2 in gastric tissue;

[0023] Among them, Relative expression of HIF-1α / VEGF / VEGFR2 (ratio to control) respectively represents the relative expression levels of HIF-1α, VEGF, or VEGFR2 (relative to the blank control group);

[0024] Figure 4 It is for determining the administration concentration of the medicated serum of the hangover tea, the ethanol concentration, the time, and the administration concentration of ethanol-induced GES-1;

[0025] Among them, Cell viability (of control%) represents cell viability (relative to the blank control group, expressed as a percentage), and JJC / Ethanol concentration represents the concentration of the medicated serum of the hangover tea or ethanol;

[0026] Figure 5 It is for the effect of the medicated serum of the hangover tea on the gene expression levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in ethanol-induced cells;

[0027] Figure 6 It is for the effect of the medicated serum of the hangover tea on the ROS level in ethanol-induced cells;

[0028] Among them, Intracelluar ROS represents intracellular ROS;

[0029] Figure 7 It is for the effect of the medicated serum of the hangover tea on the levels of NO, MDA, SOD, and CAT in ethanol-induced cells. Detailed implementation method

[0030] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings and embodiments.

[0031] Example 1 Preparation of hangover tea (aqueous extract)

[0032] Weigh 5 g of Phragmites australis rhizome, 5 g of Imperata cylindrica rhizome, 2.5 g of dried Dendrobium officinale, 2.5 g of Citrus medica var. sarcodactylis, 2.5 g of Codonopsis pilosula (superior grade), 2.5 g of Pogostemon cablin, 2.5 g of Pueraria lobata, 2.5 g of Lophatherum gracile, 1.5 g of Herba Pogostemonis (superior grade), and 2.5 g of dried tangerine peel respectively, add 10 times the amount of distilled water, reflux and extract twice, 2 h each time, filter, combine the filtrates, concentrate under reduced pressure, and dry under reduced pressure to obtain the anti-alcoholism tea (aqueous extract).

[0033] Example 2 Intervention of the anti-alcoholism tea (aqueous extract) on alcohol-induced gastric injury in mice

[0034] 1. Establishment of the alcohol-induced gastric injury mouse model and administration

[0035] Raise 7-week-old male C57BL / 6 mice with a body weight of 20 ± 3 g. The breeding temperature is 25°C and the humidity is 60 ± 5%. After 7 days of adaptive feeding, subsequent experiments are carried out. From the 8th day, randomly group and intragastrically administer: blank control group (10 ml / kg normal saline), model group (10 ml / kg normal saline), anti-alcoholism tea group (1 g / kg, 2 g / kg, 4 g / kg anti-alcoholism tea); from the 15th day, except for the mice in the blank control group intragastrically administered distilled water, mice in each group are intragastrically administered commercially available 50% ethanol (12 mL / kg × BW); once a day for 7 consecutive days to induce acute alcoholic liver injury, and weigh the body weight.

[0036] After the last administration and 12 h of fasting, take samples, photograph and weigh the gastric mucosa, draw blood from the heart, and retain the liver, stomach, ileum, cecum, and feces. After anesthetizing the mice, draw blood from the heart, separate the serum, and measure various biochemical indexes.

[0037] 2. Histopathological analysis

[0038] Take out the gastric tissue of each mouse and fix it in 10% neutral buffered formalin for 24 h. Dehydrate the tissue samples and embed them in paraffin. Each tissue wax block is sectioned (5 μm) along its entire length, and the sections are stained with hematoxylin and eosin (H&E). The H&E staining results of the tissue are shown as color images captured at a magnification of 400 times under an optical microscope.

[0039] It can be seen from Figure 1 that the gastric tissue of the mice in the blank control group showed a normal histological structure of the mucosa, submucosa, and muscular region without histological changes; while the gastric tissue of the mice in the model group was significantly damaged by ethanol, showing bleeding, erosion, and ulcers (see Figure 1 A), severe congestion and swelling of the mucosal layer, and infiltration of inflammatory cells in the submucosa (see Figure 1 B); while pretreatment with the anti-alcoholism tea can significantly reduce the gastric mucosal bleeding caused by ethanol.

[0040] 3. qRT-PCR analysis

[0041] The tissue samples were lysed using TRIzol reagent. Total RNA was extracted according to the standard operating procedure of the total RNA kit. The concentration and purity of RNA were detected using NanoDrop 2000. Reverse transcription was performed using Prime Script TM RT reagent Kit. The obtained cDNA was subjected to RT-PCR analysis using TB Premix EX Taq II kit. Each reaction system was added to a 96-well plate, and the ct values of each gene (TNF-α, IL-1β, and IL-6) were detected using a Roche LightCycler 480 real-time PCR instrument. Among them, GAPDH was used as an internal reference gene, and the results are as Figure 1 shown in Figures C-E.

[0042] The results showed that compared with the blank control group, after ethanol treatment, the mRNA expressions of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 were significantly enhanced; while the pretreatment with the anti-alcoholism tea significantly inhibited the expression levels of inflammatory factor genes in ethanol-induced mice. It is indicated that the pretreatment with the anti-alcoholism tea can improve ethanol-induced gastric mucosal lesions and effectively protect mice from ethanol-induced gastric mucosal damage.

[0043] 4. Detection using NO, MDA, SOD, and CAT kits

[0044] The levels of NO, MDA, SOD, and CAT in the gastric tissue were detected according to the kit instructions, and the results are as Figure 2 shown.

[0045] As Figure 2 can be seen, compared with the blank control group, the expression levels of NO and MDA in the gastric tissue homogenate of the model group mice were significantly increased (P < 0.01), and the expression levels of SOD and CAT were significantly decreased (P < 0.01); while the pretreatment with the anti-alcoholism tea reversed this phenomenon, indicating that the intervention with the anti-alcoholism tea can significantly reduce the increased oxidative stress level in the gastric tissue caused by ethanol.

[0046] 5. Mechanism of the anti-alcoholism tea in alleviating gastric tissue damage in mice with alcoholic gastritis

[0047] Figure 3 The Western blot results showed that compared with the blank control group, the expressions of HIF-1α, VEGF, and VEGFR2 in the model group were significantly up-regulated (P < 0.05). After treatment with the anti-alcoholism tea, the expressions of HIF-1α, VEGF, and VEGFR2 in the gastric tissue were significantly decreased, suggesting that the anti-alcoholism tea may relieve gastric tissue damage by reducing the secretion of HIF-1α, VEGF, and VEGFR2.

[0048] 6. Determination of the administration concentration of the anti-alcoholism tea-containing serum and the administration concentration of ethanol-induced GES-1

[0049] The drug concentration was screened according to the CCK-8 results to determine that the drug had no toxic effect on the cells. As Figure 4 shown in Figure A, compared with the 0% group, the serum containing 5-20% anti-alcohol tea decreased the cell viability (P < 0.01). Based on the comprehensive CCK-8 experimental results, the subsequent drug concentration was determined to be administered at a concentration of 0.01-2.5%.

[0050] The ethanol concentration was screened according to the CCK-8 results. As Figure 4 shown in Figure B, after different concentrations of ethanol acted on CES-1 cells for 2-6 h, they all caused a certain degree of cell damage to GES-1 cells. Among them, after incubating GES-1 cells with 90 mM ethanol for 4 h, the cell inhibition rate reached 71.8%. The experiment showed that incubating with a 90 mM ethanol solution for 4 h was the optimal condition for establishing a cell damage model of GES-1 cells.

[0051] The effective drug concentration was screened according to the CCK-8 results. The effects of different concentrations of anti-alcohol tea on the activity of ethanol-induced CES-1 cells are shown in Figure 4 Figure C. It can be seen that the growth of the cells showed a certain proliferation trend with the increase of the concentration, that is, with the increase of the drug concentration, the serum containing anti-alcohol tea promoted the cell growth, but there was no statistical significance. When the concentration of the serum containing the drug reached 0.1%, it promoted the growth of GES-1 cells (P < 0.05); when the concentration of the serum containing the drug reached 0.5%, it promoted the growth of GES-1 cells (P < 0.01); when the concentration of the serum containing the drug reached 1%, it promoted the growth of GES-1 cells, but there was no statistical significance. Therefore, in this experiment, the low, medium, and high doses of drug administration were set at 0.1%, 0.25%, and 0.5% respectively.

[0052] 7. Inhibition of the gene expression levels of inflammatory factors in ethanol-induced GES-1 by the serum containing anti-alcohol tea

[0053] GEC-1 cells were seeded onto 6-well microplates and divided into a blank control group, a model group, and an anti-alcohol tea group (the culture medium contained 0.1%, 0.25%, and 0.5% anti-alcohol tea serum). After incubation for 24 h, 90 mM ethanol solution was added and incubation was continued for 4 h for induction. Then, the gene expression levels of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in the cells of each group were detected, and the results are as Figure 5 shown.

[0054] It can be seen that ethanol induction significantly enhanced the mRNA expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in GEC-1 cells of the model group, while pretreatment with anti-alcohol tea down-regulated the gene expression levels of each inflammatory factor.

[0055] 8. Determination of ROS in GES-1 cells

[0056] GES-1 cells were seeded onto 6-well microplates and divided into a blank control group, a model group, and an anti-hangover tea group (the culture medium contained 0.1%, 0.25%, or 0.5% anti-hangover tea serum), and cultured for 24 h; then 90 mM ethanol was added and incubation was continued for 4 h for induction. Then, after treatment with the ROS-sensitive probe 2',7'-dichlorodihydrofluorescein (DCFH-DA; Yonsei Biotechnology, Nanjing, China) following the previously established protocol (Zhao et al., 2021), the cells were rinsed with PBS and incubated with DCFH-DA for 30 min. The fluorescence intensity was detected using a fluorescence microscope.

[0057] The results were as Figure 6 shown. Compared with the blank control group, the ROS fluorescence intensity in the model group was significantly enhanced; while after administration of anti-hangover tea serum, the ROS fluorescence intensity in the cells was significantly decreased (P < 0.01).

[0058] 9. Detection of intracellular NO, MDA, SOD, and CAT levels

[0059] GES-1 cells were treated using the above method, and then the levels of NO, MDA, SOD, and CAT in the cells were detected according to the kit instructions. The results were as Figure 7 shown.

[0060] It was Figure 7 found that compared with the blank control group, the expression levels of NO and MDA in the model group cells were significantly increased (P < 0.01), and the expression levels of SOD and CAT were significantly decreased (P < 0.01); while pretreatment with anti-hangover tea reversed this phenomenon, indicating that anti-hangover tea intervention could significantly reduce the increase in intracellular oxidative stress levels caused by ethanol.

[0061] Example 2

[0062] Patient symptoms: Li Mou, male, 42 years old, a business person, with long-term alcohol drinking for socializing, mild abnormal liver function (elevated ALT), often feeling fatigued, dry mouth and bitter taste, red tongue, slightly greasy yellow coating, and deep and slippery pulse.

[0063] Take 20 g of Pueraria lobata, 15 g of Phragmites communis root, 15 g of Imperata cylindrica root, 15 g of Dendrobium officinale, 10 g of Citrus medica var. sarcodactylis, 10 g of Codonopsis pilosula, 10 g of Pogostemon cablin, 10 g of Lophatherum gracile, 6 g of Herba Pogostemonis, and 10 g of Citrus reticulata Blanco; add 5 times the volume of water, boil, and then simmer for 2 h to obtain anti-hangover tea (decoction).

[0064] This anti-hangover tea was administered to the patient once a day for 21 consecutive days; after 21 days, a reexamination showed that the ALT index had dropped to the normal range, the post-alcohol fatigue had decreased, and the bitter taste symptom had disappeared.

[0065] Example 3

[0066] Patient information: Tan, female, 28 years old, developed vomiting, stomach pain, headache, acid reflux and heartburn after drinking excessively at a dinner party. She also had loose stools, yellow urine, dark red tongue, white tongue coating, and a deep and slightly slippery pulse.

[0067] Take 15g of Pueraria root, 20g of Phragmites australis, 20g of Imperata root, 10g of dried Dendrobium, 10g of Citrus hand, 15g of Codonopsis pilosula, 10g of Patchouli, 10g of Lophatherum gracile, 6g of Herbal Tea, and 10g of Tangerine peel; add 5 times the volume of water, boil and then simmer for 2h to obtain hangover tea (water decoction).

[0068] Give the patient this hangover tea immediately and the vomiting will be relieved within 30 minutes, and the stomach pain will be relieved and the headache will disappear after 2 hours.

[0069] Example 4

[0070] Patient information: Mr. Wang, male, 50 years old, has a long history of drinking. A physical examination one year ago revealed alcoholic fatty liver. Over the past six months, he has often felt abdominal distension and discomfort, dull pain in the liver area, dry and bitter mouth, sticky stools, slightly yellow urine, pale red tongue, white and yellow tongue coating, liver function showed abnormal ALT index, and blood lipid tests showed high triglycerides.

[0071] Take 20g of Pueraria root, 15g of Phragmites australis, 15g of Imperata root, 10g of dried Dendrobium, 10g of Citrus citron, 10g of Codonopsis pilosula, 15g of Patchouli, 10g of Lophatherum gracile, 6g of Herbal Tea, and 10g of Tangerine peel; add 5 times the volume of water, boil and then simmer for 2h to obtain hangover tea (water decoction).

[0072] The patient was given the hangover tea, one dose per day, along with a low-fat diet, for a course of three months. After the treatment, B-ultrasound showed that liver fat infiltration was reduced, abdominal distension disappeared, liver function was normal, and blood lipid indicators improved.

[0073] Example 5

[0074] Patient information: Zhang, female, 35 years old, has a long history of drinking. In the past six months, she has frequently experienced epigastric distension, loss of appetite, bitter taste in the mouth in the morning, occasional acid reflux, pale tongue, and greasy white tongue coating after drinking.

[0075] Take 15g of Pueraria root, 20g of Phragmites australis, 15g of Imperata root, 10g of dried Dendrobium, 6g of Citrus hand, 10g of Codonopsis pilosula, 10g of Patchouli, 10g of Lophatherum gracile, 6g of Herba Lycopodiellae, 10g of Citrus reticulatae, 10g of Citrus reticulatae; add 5 times the volume of water, boil and then simmer for 2h to obtain hangover tea (water decoction).

[0076] The patient was given this alcohol-relieving tea to drink as tea every day for 2 weeks. After 2 weeks, the distension in the epigastric region was significantly relieved, the appetite was restored, and the tongue coating turned thin and white.

[0077] Example 6

[0078] Patient information: Ye, male, 24 years old. Due to work reasons, the patient needs to drink alcohol frequently and hopes to reduce the risk of drunkenness. Currently, there are no obvious organic lesions found in the physical examination.

[0079] Take 15 g of Pueraria lobata, 15 g of Phragmites communis root, 15 g of Imperata cylindrica root, 10 g of Dendrobium officinale, 10 g of Citrus medica var. sarcodactylis, 10 g of Codonopsis pilosula, 10 g of Pogostemon cablin, 10 g of Lophatherum gracile, 6 g of Herba Pogostemonis, 10 g of Citrus reticulata Blanco; add 5 times the volume of water, boil and then simmer for 2 h to obtain the anti-hangover tea (decoction).

[0080] Give the patient the anti-hangover tea 1 hour before drinking, and then drink alcohol as normal. The drunkenness time is delayed by 2 hours under the same amount of alcohol consumption, and the hangover reaction is reduced the next day.

Claims

1. A Chinese medicine composition, characterized in that: Calculated by weight, the drug comprises the following raw materials: 15-20 parts of kudzu root, 15-20 parts of reed root, 15-20 parts of Imperata root, 10-15 parts of dried dendrobium, 6-10 parts of bergamot, 10-15 parts of codonopsis pilosula, 10-15 parts of patchouli, 10-15 parts of lophatherum gracile, 6-10 parts of herbal tea, and 10-15 parts of tangerine peel.

2. Use of the Chinese medicine composition as claimed in claim 1 in preparing a drug for preventing and treating alcoholic gastritis.

3. A hangover-relief tea, characterized in that: The effective ingredients thereof at least include the water extract or water decoction of the traditional Chinese medicine composition as claimed in claim 1.

4. The hangover-relief tea according to claim 3, characterized in that The aqueous extract is prepared by the following method: (1) adding 10 times the volume of distilled water to the traditional Chinese medicine composition, refluxing and extracting to obtain a filtrate; (2) All filtrates are combined, concentrated and dried to obtain the water extract.

5. The hangover-relief tea according to claim 4, characterized in that In step (1), reflux extraction is performed at least twice, each time for at least 2 hours.

6. The hangover-relief tea according to claim 3, characterized in that: Add 8-12 times the volume of water to the traditional Chinese medicine composition, and simmer for at least 2 hours to obtain the water decoction.

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