Ultra-low volume liquid for preventing and treating sugarcane weeds
By using the combination of nitrosulone and atrazine in the herbicide and adding mutton acid as a synergist, an ultra-low capacity liquid is prepared, which solves the problem of weed resistance after long-term use of existing herbicides, and achieves the purpose of significant synergistic effects on a variety of weeds and delays the development of drug resistance.
Patent Information
- Application Number
- CN202510306753.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-15
- Publication Date
- 2025-06-13
AI Technical Summary
After long-term use of existing herbicides, weeds are prone to develop resistance, resulting in reduced efficacy, and the effect of synergists is highly selective and cannot significantly synergize various weeds.
A super low-capacity liquid agent was prepared by combining nitrosulone and atrazine compound as the active ingredient and using mutton acid as a synergist. The mass ratio of nitrosulone, atrazine and mutton acid was optimized to improve the prevention effect of weeds.
The prevention effect of the combination of nitrosulphone and atrazine on weeds was significantly improved, delayed the development of drug resistance, reduced the dosage of the drug, and the ED50 value was lower than the ED50 value of any single dose, proving the advantages of synergistic effects.
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Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of ultra-low volume liquid agents, and particularly relates to an ultra-low volume liquid agent for controlling sugarcane weeds. Background Art
[0002] Weed damage in sugarcane fields is an important cause of sugarcane yield reduction. Since manual weeding is time-consuming, laborious and costly, the use of herbicides has become the main means of controlling weeds in sugarcane fields. However, the control spectrum of a single herbicide is limited, and continuous use easily makes weeds develop drug resistance, resulting in reduced drug efficacy. Mixing different herbicidal active ingredients is one of the effective and convenient ways for weed resistance management.
[0003] In the prior art, it has been disclosed that the mixture of mesotrione and atrazine can improve the control effect against resistant weeds and delay the emergence of resistance in resistant weeds. However, in the actual application process, even if the mixture delays the emergence of resistance, the weeds with existing resistance genes may still spread and gradually accumulate. Adding a suitable type and dose of synergist to the mixed agent can further delay the development of drug resistance and significantly reduce the long-term input of resistance management.
[0004] However, the effect of synergists is highly selective. It has a significant synergistic effect on specific weeds, but may be ineffective for other species. For example, silicone synergist can increase the absorption rate of cyhalofop-butyl by barnyardgrass by 80%, but only increase the absorption rate of cyhalofop-butyl by green foxtail by 20%. Moreover, even for the same synergist and the same herbicide, when the control targets are different, opposite effects may occur. For example, for mesotrione + atrazine + silicone, silicone will accelerate the penetration of mesotrione on corn leaves, which will instead increase the risk of phytotoxicity and thus lead to yield reduction; for diquat + glufosinate + mineral oil, mineral oil closes the stomata and hinders the rapid contact killing effect of diquat, reducing the control effect on weeds.
[0005] Caprylic acid, also known as n-octanoic acid, has the molecular formula C 8 H 16 O 2 , is a colorless and transparent oily liquid, widely present in nutmeg, lemon, apple, hops, etc., and is mainly used for making dyes, drugs, spices, plasticizers, etc. There has been no relevant report on using caprylic acid as a synergist for the mixture of mesotrione and atrazine. Summary of the Invention
[0006] The object of the present invention is to provide an ultra-low volume liquid agent for controlling sugarcane weeds, and its synergist can improve the control effect of the mixture of mesotrione and atrazine on weeds, which is of great significance for further delaying the development of drug resistance.
[0007] To achieve the above object, the present invention provides the following technical solutions:
[0008] An ultra-low volume liquid agent for controlling sugarcane weeds, the ultra-low volume liquid agent comprising an active ingredient and a synergist, the active ingredient being compounded by mesotrione and atrazine, and the synergist being caproic acid.
[0009] Further, the mass ratio of mesotrione, atrazine and caproic acid is 1:1.5:0.4 - 0.6
[0010] Further, the mass ratio of mesotrione, atrazine and caproic acid is 1:1.5:0.5.
[0011] Further, the ultra-low volume liquid agent further comprises one or several of a solvent, an anti-drift agent, an anti-evaporation agent, a stabilizer, a pH regulator, a safener, a dispersant, a silane coupling agent, a warning color and an antifreeze agent.
[0012] Further, the solvent is soybean vegetable oil; the anti-drift agent is polyacrylate; the anti-evaporation agent is methyl oleate; the stabilizer is dibutylhydroxytoluene; the pH regulator is 2% citric acid ethanol solution; the safener is fenclorim; the dispersant is fatty alcohol polyoxyethylene ether; the silane coupling agent is KH550; the warning color is solvent blue 35; the antifreeze agent is ethylene glycol.
[0013] Further, by mass percentage, the ultra-low volume liquid agent is prepared from the following components: mesotrione 6 - 12%, atrazine 12 - 18%, caproic acid 3 - 8%, anti-drift agent 0.2 - 0.5%, anti-evaporation agent 5 - 8%, stabilizer 0.1 - 0.3%, pH regulator 0.05 - 0.1%, safener 0.5 - 1%, dispersant 2 - 5%, silane coupling agent 1.2 - 1.6%, and the solvent is supplemented to 100%.
[0014] Further, by mass percentage, the ultra-low volume liquid agent is prepared from the following components: mesotrione 10%, atrazine 15%, caproic acid 5%, anti-drift agent 0.3%, anti-evaporation agent 6%, stabilizer 0.2%, pH regulator 0.1%, safener 1%, dispersant 3%, silane coupling agent 1.4%, and the solvent is supplemented to 100%.
[0015] Compared with the prior art, the present invention has the following beneficial effects:
[0016] (1) When the present invention uses caproic acid as a synergist for the compound combination of mesotrione and atrazine, when the mass ratio is 1:1.5:0.5, the co-toxicity coefficient value reaches 373.360, and the synergistic effect is significant. At the same time, the ED 50 value is also significantly lower than the ED of any single agent 50Value. It shows that when the mass ratio of mesotrione, atrazine and caprylic acid is 1:1.5:0.5, the synergistic effect of caprylic acid on the mesotrione and atrazine compound combination is optimal. Therefore, caprylic acid can be used as a synergist for the mesotrione and atrazine compound combination, which helps to improve the control effect of the mesotrione and atrazine compound combination on weeds and reduce the dosage of the mesotrione and atrazine agents. This is of great significance for further delaying the development of weed resistance.
[0017] (2) The present invention selects a compound combination of mesotrione and atrazine as the active ingredient, selects caprylic acid as the synergist, and adds other auxiliaries to prepare an ultra-low volume liquid agent, which can provide support for the ultra-low volume liquid agent for controlling sugarcane weeds. Detailed implementation mode
[0018] The technical solution of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts belong to the scope of protection of the present invention.
[0019] Example 1: Indoor bioassay
[0020] 1.1 Test weeds
[0021] Echinochloa crusgalli
[0022] 1.2 Test agents
[0023] 99% caprylic acid, 98% mesotrione, 95% atrazine.
[0024] The test agents were dissolved and diluted to a single-agent mother liquor of 5000 mg / L with a 0.1% Tween-80 aqueous solution. According to the preliminary pre-test, multiple groups of ratios were set. Then, the single-agent mother liquor and each group of ratio mixed agents were diluted into 5 mass concentration gradients, and the above agents were prepared and used immediately.
[0025] 1.3 Test method: (Refer to "NY / T 1155.4-2006 Pesticide indoor bioassay test guidelines Herbicides Part 4: Activity determination test Stem and leaf spray method").
[0026] The Echinochloa crusgalli seeds were sown in plastic pots, 15 seeds per pot. Keep the soil moist and cultivate under room temperature and 12 h of light. After the weed seedlings grew to the 3-leaf stage, thin out the seedlings, and leave 10 weed seedlings with consistent growth in each pot. Spray the prepared liquid medicine on the stems and leaves of the weed seedlings with a spray tower. Each treatment was repeated 5 times, and at the same time, a treatment of spraying a 0.1% Tween-80 aqueous solution was set as the blank control. After 14 days, weigh the fresh weight of the above-ground part of the weeds and calculate the fresh weight control effect.
[0027]
[0028] In the above formula: E--fresh weight control efficacy (%), C--fresh weight of the above-ground part of the control weeds (g), T--fresh weight of the above-ground part of the treated weeds (g).
[0029] 1.4 Data analysis
[0030] Perform regression analysis on the logarithm of the agent concentration and the probit value of the control efficacy to obtain the regression equation and ED50 of different agent treatments. Calculate the co-toxicity coefficient of the mixture using the Sun Yunpei method to evaluate the type of action: CTC ≤ 80 is antagonistic action, 80 < CTC < 120 is additive action, and CTC ≥ 120 is synergistic action. The results are shown in Table 1.
[0031]
[0032] In the above formula: ATI--actual toxicity index of the mixture; S--ED of the standard agent 50 , with the unit of g a.i. / hm 2 ; M--ED of the test agent 50 , with the unit of g a.i. / hm 2 .
[0033] TTI = TI A ×P A +TI B ×P B
[0034] In the above formula: TTI--theoretical toxicological index of the mixture; TI A --toxicity index of agent A; P A --percentage content of agent A in the mixture, with the unit of percentage (%); TI B --toxicity index of agent B; P B --percentage content of agent B in the mixture, with the unit of percentage (%).
[0035]
[0036] In the above formula: CTC--co-toxicity coefficient; ATI--actual toxicity index of the mixture; TTI--theoretical toxicity index of the mixture.
[0037] Table 1 Results of indoor bioassay
[0038]
[0039]
[0040] As can be seen from the results in Table 1, the compounding of mesotrione and atrazine showed a synergistic effect on controlling Echinochloa crusgalli, while the compounding of mesotrione, atrazine and caprylic acid showed antagonistic and additive effects on controlling Echinochloa crusgalli, respectively.
[0041] When caprylic acid was used as a synergist for the compounding combination of mesotrione and atrazine, when the mass ratio of mesotrione, atrazine and caprylic acid was 1:1.5:0.3 and 1:1.5:0.7, it showed an additive effect; although when the mass ratio was 1:1.5:0.4 or 1:1.5:0.6, it would show a synergistic effect, but the co-toxicity coefficient values at this time were all less than the co-toxicity coefficient value of the compounding of mesotrione and atrazine, and at the same time, the ED 50 value was close to or even higher than that of mesotrione single agent. When the mass ratio was 1:1.5:0.5, the co-toxicity coefficient value reached 373.360, which was significantly different, and at the same time, the ED 50 value was also significantly lower than the ED 50 value of any single agent.
[0042] Example 2: Ultra-low volume liquid agent
[0043] The formulation is shown in Table 2.
[0044] Table 2 Formulation of ultra-low volume liquid agent
[0045]
[0046]
[0047] The preparation method of the above ultra-low volume liquid agent includes the following steps:
[0048] S1. Add 54% of the total amount of plant soybean oil in the formulation to the mixing tank, heat it to 40°C, then add mesotrione, and shear and dissolve it at 1500 rpm for 20 min (after passing through a 100-mesh sieve); add atrazine (after passing through a 100-mesh sieve), and stir and disperse it at 500 rpm for 30 min under the protection of nitrogen (5 L / min);
[0049] S2. Stir and mix 3% of the total amount of plant soybean oil in the formulation with polyacrylate at 300 rpm evenly, and then add it to the mixing tank in S1, and shear it at 2000 rpm for 10 min;
[0050] S3. Dissolve fenclorim and the remaining plant soybean oil by stirring in a 50°C water bath, and then add it to the mixing tank in S1, and stir at 500 rpm for 10 min at 40°C;
[0051] S4. Add the remaining formulation raw materials in sequence, shear at high speed at 2500 rpm for 15 min, cool down to 25°C, and remove impurities with a 5-μm filter screen to obtain the ultra-low volume liquid agent.
Claims
1. An ultra-low volume liquid for controlling sugarcane weeds, characterized in that: The ultra-low volume liquid comprises an active ingredient and a synergist, wherein the active ingredient is compounded by mesotrione and atrazine, and the synergist is caprylic acid.
2. The ultra-low volume liquid according to claim 1, characterized in that: The mass ratio of mesotrione, atrazine and caprylic acid is 1:1.5:0.4-0.
6.
3. The ultra-low volume liquid according to claim 1, characterized in that: The mass ratio of mesotrione, atrazine and caprylic acid is 1:1.5:0.
5.
4. The ultra-low volume liquid according to claim 1, characterized in that: The ultra-low volume liquid also includes one or more of a solvent, an anti-drift agent, an anti-evaporation agent, a stabilizer, a pH regulator, a safener, a dispersant, a silane coupling agent, a warning color and an antifreeze agent.
5. The ultra-low volume liquid according to claim 4, characterized in that: The solvent is soybean vegetable oil; the anti-drift agent is polyacrylate; the anti-evaporation agent is methyl oleate; the stabilizer is butylated hydroxytoluene; the pH adjuster is 2% citric acid ethanol solution; the safener is fenthiocarb; the dispersant is fatty alcohol polyoxyethylene ether; the silane coupling agent is KH550; the warning color is solvent blue 35; and the antifreeze agent is ethylene glycol.
6. The ultra-low volume liquid according to claim 4, characterized in that: The ultra-low volume liquid is prepared from the following components in percentage by mass: 6-12% of mesotrione, 12-18% of atrazine, 3-8% of caprylic acid, 0.2-0.5% of anti-drift agent, 5-8% of anti-evaporation agent, 0.1-0.3% of stabilizer, 0.05-0.1% of pH regulator, 0.5-1% of safener, 2-5% of dispersant, 1.2-1.6% of silane coupling agent, and the solvent is supplemented to 100%.
7. The ultra-low volume liquid according to claim 4, characterized in that: The ultra-low volume liquid is prepared from the following components in percentage by mass: 10% of mesotrione, 15% of atrazine, 5% of caprylic acid, 0.3% of anti-drift agent, 6% of anti-evaporation agent, 0.2% of stabilizer, 0.1% of pH regulator, 1% of safener, 3% of dispersant, 1.4% of silane coupling agent, and the solvent is supplemented to 100%.