Fixing device convenient for eye disease examination and eye operation treatment of mouse

Abstract

The invention designs a fixing device convenient for eye disease examination and eye operation treatment of a mouse. The fixing device comprises a clamping assembly, a horizontal moving mechanism, a front-back moving mechanism and a clamping mechanism, the horizontal moving mechanism is fixedly installed at the upper end of the clamping assembly, the front-back moving mechanism is movably installed at the upper end of the horizontal moving mechanism, and the clamping mechanism is fixedly installed at the upper end of the front-back moving mechanism. The clamping mechanism can move front and back, left and right through the horizontal moving mechanism and the front-back moving mechanism so that the clamping mechanism can be moved to the corresponding position of ophthalmic examination equipment, and the whole device can be clamped to the lower jaw support part of the slit lamp through the clamping assembly. The front end of the clamping mechanism is of an arc-shaped structure, so that the clamping mechanism can adapt to slit lamps of different models and can fix the slit lamps on ophthalmic examination equipment; for hospitals without special animal experiment operation platforms, the device can be used after being matched, and the defect that a special test bed is needed can be effectively overcome.

Description

Technical Field

[0001] The present invention belongs to the technical field of experimental animal fixing instruments, and particularly relates to a fixing device convenient for eye disease examination and eye operation treatment of mice. Background Art

[0002] In ophthalmic animal experiments on mice, devices such as fundus cameras and fundus lasers are increasingly widely used. They provide crucial evidence for in-depth research on the occurrence mechanism, development process, and drug efficacy evaluation of mouse eye diseases. However, due to the small size of mice and the significant differences in their physiological structures from humans, during the experiment, it is difficult to accurately fix the eye position and body position of mice. For example, the eyeballs are tiny, and at the same time, the eye structures are delicate, with high requirements for fine position adjustment, and it is difficult to continuously fix them by hand.

[0003] Therefore, it is particularly necessary to develop a suitable mouse fixing device to assist related eye examinations and experiments. Currently, although there are some mouse fixing devices, such as a mouse fixing device for ophthalmic high-resolution detection experiments disclosed in the patent with the publication number CN111134889B. This device designs the ear rod as a Z shape and moves the connection of the ear rod on the main body of the fixing device backward, so that there is no mechanical structure for fixing around the eyes of the mouse; at the same time, the mouth fixing structure is greatly simplified, and on the premise of ensuring its adjustable and fixable functions, the volume of this part is minimized as much as possible, providing convenience for examination and operation to a certain extent.

[0004] However, after the mouse is fixed by this device, there is no corresponding position adjustment device to adjust the position of the mouse. Moreover, the way it fixes the mouse's head is to directly press a relatively sharp structure against the mouse's head, which will inevitably cause harm to the mouse during the operation, resulting in the mouse being more restless. In addition, this device cannot effectively cooperate with the existing commonly used slit lamps in ophthalmology. For hospitals without a dedicated animal experiment operation platform, it is not convenient to use and difficult to achieve adaptation, and there are still deficiencies to a certain extent.

[0005] Therefore, a fixing device convenient for eye disease examination and eye operation treatment of mice is needed to solve the above technical problems. Summary of the Invention

[0006] To solve the above technical problems, the present invention designs a fixing device for facilitating the examination and ophthalmic operation treatment of mouse eye diseases. This device can be used in conjunction with existing commonly used ophthalmic examination instruments (taking a slit lamp as an example). For hospitals without a dedicated animal experiment operation platform, this device can be adapted for use, effectively solving the defect of the need for a dedicated test bench. At the same time, this device can effectively fix the head of the mouse, and after fixation, the eyes of the mouse can be completely exposed, and the head fixing device will not affect the eyes. In addition, when fixing the head of the mouse, this device uses a conical fixing design to restrict and fix the head of the mouse, replacing the traditional method of directly pressing a sharp fixing structure against the head of the mouse for fixation, which can effectively reduce the restlessness of the mouse and ensure the stability of the mouse during the examination. At the same time, this device can fix the head of the mouse, and after adjustment, it can be directly fixed without the need to continuously hold it by hand.

[0007] To achieve the above technical effects, the present invention discloses a fixing device for facilitating the examination and ophthalmic operation treatment of mouse eye diseases, including: a clamping assembly, a horizontal moving mechanism, a front-back moving mechanism, and a clamping mechanism; the horizontal moving mechanism is fixedly installed at the upper end of the clamping assembly, the front-back moving mechanism is movably installed at the upper end of the horizontal moving mechanism, and the clamping mechanism is fixedly installed at the upper end of the front-back moving mechanism.

[0008] The clamping mechanism includes: a support plate, a head clamping assembly, and an arc-shaped clamping plate; the support plate is fixedly installed at the upper end of the front-back moving mechanism, the head clamping assembly is installed on one side of the upper end of the support, and the arc-shaped clamping plate is detachably installed at the rear end of the head clamping assembly and on the upper end of the support plate; the head and torso of the mouse are fixed by the head clamping assembly and the arc-shaped clamping plate respectively to ensure the stability of the mouse.

[0009] Further, the head clamping assembly includes: a movable clamping block and a fixed clamping block. The lower end of the movable clamping block is movably installed on the support plate through a slider and is on the same plane as the fixed clamping block; semi-circular grooves are provided on both the movable clamping block and the fixed clamping block, and a head limiting plate is fixedly installed at the front end of the semi-circular groove.

[0010] An adjusting knob is movably installed at the uppermost end of the semi-circular groove of the movable clamping plate, and a head fixing plate is fixedly installed at the end of the adjusting knob; a fixed buckle is fixedly installed on the side wall of the movable clamping block; a release rod is movably installed at the upper end of the fixed clamping block, a spring is sleeved outside the release rod, and the spring is limited by a limiting block arranged inside the fixed clamping block of the movable clamping block; the release rod is directly opposite to the upper end of the fixed buckle, and the fixed buckle can be fixed on a clamping block arranged inside the fixed clamping block, and at the same time, the end of the fixed buckle is connected through a rotating shaft.

[0011] Further, a number of square grooves are symmetrically arranged in an array at the upper end of the support plate, and side grooves are arranged on the inner side walls of the square grooves. Limit bars are fixedly arranged at both ends of the arc-shaped clamping plate, and detachable installation is achieved through the mutual cooperation of the limit bars and the side grooves.

[0012] Further, the arc-shaped clamping plate is made of an elastic material.

[0013] Further, the clamping assembly includes a clamping base and a fixing knob; the clamping assembly is of a U-shaped structure, and the fixing knob is movably installed on the clamping base through threads, and the front end of the clamping base is of an arc-shaped structure; a control module is also fixedly arranged on the rear side wall of the clamping base.

[0014] Further, the horizontal movement mechanism and the front-back movement mechanism have the same structure. The horizontal movement mechanism includes a first motor, a first chute, and a first screw; the front-back movement mechanism includes a second chute, a second screw, and a second motor; the first screw is fixedly installed on the output shaft of the first motor, and the first screw is installed on the first chute, and the horizontal movement of the front-back movement mechanism is controlled by the forward or reverse rotation of the first motor; similarly, the front-back movement of the clamping mechanism is controlled by the front-back movement mechanism.

[0015] The beneficial effects of the present invention are:

[0016] The present invention designs a fixing device convenient for the examination and ocular operation and treatment of mouse eye diseases, including: a clamping assembly, a horizontal movement mechanism, a front-back movement mechanism, and a clamping mechanism; the horizontal movement mechanism is fixedly installed at the upper end of the clamping assembly, the front-back movement mechanism is movably installed at the upper end of the horizontal movement mechanism, and the clamping mechanism is fixedly installed at the upper end of the front-back movement mechanism; the horizontal movement mechanism and the front-back movement mechanism provided can move the clamping mechanism left, right, front, and back, so as to move it to the corresponding position irradiated by the ophthalmic examination equipment; at the same time, the entire device can be clamped on the ophthalmic examination equipment through the provided clamping assembly; the front end of the clamping mechanism is of an arc-shaped structure, which can adapt to different models of slit lamps; so as to be able to fix it on the mandibular support part of the slit lamp; for hospitals without a dedicated animal experiment operation platform, this device can be adapted for use, effectively solving the defect of the need for a dedicated test bench.

[0017] In addition, the clamping mechanism provided can clamp the mouse, and at the same time, the clamping mechanism is provided with corresponding structures for fixing the mouse's head and body; the mouse's head can be firmly fixed to prevent it from turning left and right. At the same time, by setting the head limiting plate to replace the traditional method of clamping the mouse's head with a sharp structure, the restlessness of the mouse can be effectively reduced, ensuring the stability of the mouse during the examination. Description of the Drawings

[0018] To more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments.

[0019] Figure 1 It is a schematic diagram of the overall structure of a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases;

[0020] Figure 2 It is a side view of a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases;

[0021] Figure 3 It is another schematic diagram of the overall structure of a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases;

[0022] Figure 4 It is an exploded view of a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases;

[0023] Figure 5 It is a partial schematic diagram of the head clamping assembly of a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases;

[0024] Figure 6 It is a partial sectional schematic diagram of the head clamping assembly of a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases;

[0025] Figure 7 It is a top view of the head clamping mechanism of Embodiment 3 in a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases;

[0026] Figure 8 It is a schematic diagram of the overall structure of the head clamping mechanism of Embodiment 3 in a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases;

[0027] Figure 9 It is a side view of the head clamping mechanism of Embodiment 3 in a fixing device for facilitating the examination and ocular operation and treatment of mouse eye diseases.

[0028] In the drawings, the list of components represented by each reference numeral is as follows:

[0029] 1 - Clamping assembly, 11 - Fixed knob, 12 - Clamping base, 13 - Control module, 2 - Horizontal movement mechanism, 21 - First motor, 22 - First chute, 23 - First screw, 3 - Front - rear movement mechanism, 31 - Second chute, 311 - Second screw, 312 - Second motor, 4 - Clamping mechanism, 40 - Support plate, 41 - Head clamping assembly, 410 - Slide block, 411 - Movable clamping block, 412 - Fixed clamping block, 413 - Adjusting knob, 414 - Head fixing plate, 415 - Head limiting plate, 416 - Fixed buckle, 4161 - Rotating shaft, 417 - Release rod, 4171 - Spring, 4172 - Limiting block, 4173 - Clamping block, 42 - Square groove, 421 - Side groove, 43 - Arc - shaped clamping plate, 431 - Limiting strip, 441 - Damping ball head, 442 - Head support plate, 443 - Limiting post, 444 - Head fixing belt, 45 - Turntable. Detailed implementation mode

[0030] Embodiment 1

[0031] A fixing device for facilitating the examination of mouse eye diseases and eye operation and treatment, comprising: a clamping assembly 1, a horizontal movement mechanism 2, a front - rear movement mechanism 3, and a clamping mechanism 4; the upper end of the clamping assembly 1 is fixedly installed with the horizontal movement mechanism 2, the upper end of the horizontal movement mechanism 2 is movably installed with the front - rear movement mechanism 3, and the upper end of the front - rear movement mechanism 3 is fixedly installed with the clamping mechanism 4;

[0032] The clamping mechanism 4 includes: a support plate 40, a head clamping assembly 411, and an arc - shaped clamping plate 43; the support plate 40 is fixedly installed at the upper end of the front - rear movement mechanism 3, the head clamping assembly 411 is installed on one side of the upper end of the support, and the arc - shaped clamping plate 43 is detachably installed at the rear end of the head clamping assembly 411, on the upper end of the support plate 40; the head and torso of the mouse are fixed by the head clamping assembly 411 and the arc - shaped clamping plate 43 respectively to ensure the stability of the mouse.

[0033] Embodiment 2

[0034] In this embodiment, based on the head clamping assembly 411 described in Embodiment 1, the head clamping assembly 411 includes: a movable clamping block 411 and a fixed clamping block 412. The lower end of the movable clamping block 411 is movably installed on the support plate 40 through a slide block 410 and is in the same plane as the fixed clamping block 412. As the installation basis of the head clamping assembly 411 and the arc - shaped clamping plate 43, it is fixed at the upper end of the front - rear movement mechanism 3; semi - circular grooves are provided on both the movable clamping block 411 and the fixed clamping block 412, and a head limiting plate 415 is fixedly installed at the front end of the semi - circular groove. The semi - circular groove is provided to adapt to the head structure of the mouse;

[0035] The movable clamping plate is movably installed with an adjusting knob 413 at the uppermost end of the semi-circular groove. The end of the adjusting knob 413 is fixedly installed with a head fixing plate 414. The adjusting knob 413 is fixedly installed in a threaded manner. Considering that after the head of the mouse is fixed by the semi-circular groove structure, when the mouse is small in size, there will still be a corresponding movement space for its head. Therefore, the head fixing plate 414 can be used to further fix it to prevent it from moving. At the same time, a fixing buckle 416 is fixedly installed on the side wall of the movable clamping block 411. The upper end of the fixed clamping block 412 is movably installed with a release rod 417. A spring 4171 is sleeved outside the release rod 417. The spring 4171 is limited by a limiting block 4172 arranged inside the fixed clamping block 412 and the movable clamping block 411. The release rod 417 is directly opposite to the upper end of the fixing buckle 416. The fixing buckle 416 can be fixed on a clamping block 4173 arranged inside the fixed clamping block 412. At the same time, the end of the fixing buckle 416 is connected by a rotating shaft 4161. When in use, directly slide the movable clamping block 411 so that the fixing buckle 416 can be fixed on the clamping block 4173. After use, directly press the release rod 417. The release rod 417 gradually contacts and presses the fixing buckle 416. At the same time, since the front end of the fixing buckle 416 is rotationally connected by a rotating shaft 4161, it will be compressed, so that the relative fixing effect between the fixing buckle 416 and the clamping block 4173 is lost. At this time, the movable clamping block 411 and the fixed clamping block 412 can be separated from each other. By using the head limiting plate 415 to replace the traditional sharp structure and combining structures such as the movable and fixed clamping blocks 412, the adjusting knob 413 and the head fixing plate 414, the head of the mouse can be stably fixed, preventing it from turning left and right, and not causing harm to the mouse. The fixing force can be adjusted according to the size of the mouse head by the adjusting knob 413, reducing the discomfort of the mouse, reducing the restlessness degree, ensuring the stability of the mouse during the inspection, and thus improving the accuracy and reliability of the experimental data.

[0036] At the same time, in this embodiment, based on the support plate 40 described in Embodiment 1, a plurality of square grooves 42 are symmetrically arranged in an array at the upper end of the support plate 40. A side groove 421 is arranged on the inner side wall of the square groove 42. Limit strips 431 are fixedly arranged at both ends of the arc-shaped clamping plate 43. The detachable installation is realized through the mutual cooperation of the limit strips 431 and the side grooves 421. The arc-shaped clamping plate 43 can elastically deform according to the body shape of the mouse and stably fix the trunk of the mouse. Cooperating with the head clamping assembly 411, the stability of the overall fixation of the mouse is further enhanced, ensuring the fixed position of the mouse during the experimental process and providing guarantee for the smooth progress of the experiment.

[0037] Embodiment 3

[0038] In this embodiment, the entire device can be clamped on the ophthalmic examination equipment by the provided clamping assembly 1 (in this embodiment, taking the slit lamp, a commonly used examination equipment in ophthalmology, as an example. Of course, this device can be clamped on slit lamps including but not limited to slit lamps); at the same time, the front end of the clamping mechanism 4 is an arc-shaped structure, which can adapt to different models of slit lamps. The clamping assembly 1 includes a clamping base 12 and a fixing knob 11; the clamping assembly 1 is a U-shaped structure, and the fixing knob 11 is movably installed on the clamping base 12 through threads, and the front end of the clamping base 12 is an arc-shaped structure; a control module 13 is also fixedly installed on the rear side wall of the clamping base 12. Some existing mouse fixing devices cannot effectively cooperate with the commonly used slit lamps in ophthalmology, and have poor adaptability to hospitals without special animal experiment operation platforms. This structure can firmly clamp the device on the chin rest part of the slit lamp, and the arc-shaped front end can fit different models of slit lamps, with a wide adaptation range. By adjusting the fixing knob 11, a stable connection between the device and the slit lamp is achieved, enabling hospitals without special platforms to use this device, solving the problem of relying on a special test bench, and reducing the experimental cost and equipment requirements.

[0039] Meanwhile, in this embodiment, based on the horizontal movement mechanism 2 and the front-back movement mechanism 3 described in Embodiment 1, the horizontal movement mechanism 2 and the front-back movement mechanism 3 have the same structure. The horizontal movement mechanism 2 includes a first motor 21, a first chute 22, and a first screw 23; the front-back movement mechanism 3 includes a second chute 31, a second screw 311, and a second motor 312; the first screw 23 is fixedly installed on the output shaft of the first motor 21, and the first screw 23 is installed on the first chute 22. The horizontal movement of the front-back movement mechanism 3 is controlled by the forward or reverse rotation of the first motor 21; similarly, the front-back movement of the clamping mechanism 4 is controlled by the front-back movement mechanism 3. Traditional mouse fixing devices lack a position adjustment device after fixation, making it difficult to adjust the mouse's eye position to a suitable examination or operation position. Traditional devices simply fix the mouse, but after fixation, it is often necessary to finely adjust the mouse's position; through the translation mechanism and the front-back movement mechanism 3, the clamping mechanism 4 can be accurately moved left and right and front and back. It can quickly and conveniently move the mouse to the best position irradiated by the slit lamp, meet different examination and operation requirements, improve the convenience and accuracy of experimental operations, enhance the experimental efficiency, and ensure that experimenters can more efficiently perform fundus examinations and operation treatments on mice.

[0040] Embodiment 4

[0041] In this embodiment, another head clamping mechanism for clamping and fixing a mouse's head is provided. Specifically, as Figure 7 、 Figure 8 、 Figure 9As shown in the figure; specifically, the head clamping mechanism includes a damping ball head 441 and a head support plate 442; the damping ball head 441 is movably installed at the upper end of the head support plate 442, the head support plate 442 is in a trapezoidal structure, limit posts are fixedly installed around the upper end of the head support plate 442, and a head fixing strap 444 is fixedly installed on one side of the rear end of the head support plate 442; at the same time, a turntable is further provided at the lower end of the head support plate 442, and at the same time the turntable 45 has a damping effect; at the same time, the head of the mouse can be fixed by the provided head support plate 442 and the fixing strap, and during the fixing process, the limit is carried out by the limit post 443; the angle of the head of the mouse can be arbitrarily adjusted by the provided damping ball head 441, so that the position of the head of the mouse after adjustment is fixed.

[0042] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific embodiments described.

Claims

1. A fixing device for convenient examination of eye diseases and eye operation treatment of mice, characterized in that: Clamping assembly, horizontal movement mechanism, front-back movement mechanism, clamping mechanism; the upper end of the clamping assembly is fixedly installed with the horizontal movement mechanism, the upper end of the horizontal movement mechanism is movably installed with the front-back movement mechanism, and the upper end of the front-back movement mechanism is fixedly installed with the clamping mechanism; The clamping mechanism includes: a support plate, a head clamping assembly, and an arc-shaped clamping plate; the support plate is fixedly installed at the upper end of the front-back movement mechanism, the head clamping assembly is installed on one side of the upper end of the support, and the arc-shaped clamping plate is detachably installed at the rear end of the head clamping assembly and at the upper end of the support plate; the head and torso of the mouse are fixed by the head clamping assembly and the arc-shaped clamping plate respectively to ensure the stability of the mouse.

2. A fixing device for convenient eye disease inspection and eye operation treatment of mice according to claim 1, characterized in that: The head clamping assembly includes: a movable clamping block and a fixed clamping block, the lower end of the movable clamping block is movably installed on the support plate through a slider and is on the same plane as the fixed clamping block; semi-circular grooves are formed on both the movable clamping block and the fixed clamping block, and a head limiting plate is fixedly installed at the front end of the semi-circular groove; An adjusting knob is movably installed at the uppermost end of the semi-circular groove of the movable clamping plate, and a head fixing plate is fixedly installed at the end of the adjusting knob; a fixed buckle is fixedly installed on the side wall of the movable clamping block; a release rod is movably installed at the upper end of the fixed clamping block, a spring is sleeved outside the release rod, and the spring is limited by a limiting block arranged inside the fixed clamping block of the movable clamping block; the release rod is directly opposite to the upper end of the fixed buckle, and the fixed buckle can be fixed on a clamping block arranged inside the fixed clamping block, and at the same time, the end of the fixed buckle is connected through a rotating shaft.

3. A fixing device for convenient eye disease inspection and eye operation treatment of mice according to claim 1, characterized in that: A plurality of square grooves are symmetrically arranged in an array at the upper end of the support plate, side grooves are arranged on the inner side walls of the square grooves, and limiting strips are fixedly arranged at both ends of the arc-shaped clamping plate, and the detachable installation is realized through the mutual cooperation of the limiting strips and the side grooves.

4. A fixing device for convenient eye disease inspection and eye operation treatment of mice according to claim 1, characterized in that: Including: The arc-shaped clamping plate is made of an elastic material.

5. A fixing device for convenient eye disease inspection and eye operation treatment of mice according to claim 1, characterized in that: The clamping assembly includes a clamping base and a fixing knob; the clamping assembly is of a U-shaped structure, and the fixing knob is movably installed on the clamping base through threads, and the front end of the clamping base is of an arc-shaped structure; a control module is also fixedly arranged on the rear side wall of the clamping base.

6. A fixing device for convenient eye disease inspection and eye operation treatment of mice according to claim 1, characterized in that: The horizontal movement mechanism and the front-back movement mechanism have the same structure. The horizontal movement mechanism includes a first motor, a first chute, and a first screw; the front-back movement mechanism includes a second chute, a second screw, and a second motor; the first screw is fixedly installed on the output shaft of the first motor, the first screw is installed on the first chute, and the horizontal movement of the front-back movement mechanism is controlled by the forward or reverse rotation of the first motor; similarly, the front-back movement of the clamping mechanism is controlled by the front-back movement mechanism.

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