Bowel-relaxing oral liquid and preparation method thereof

Abstract

The invention discloses a bowel-relaxing oral liquid and a preparation method thereof. The invention relates to the technical field of medicines, in particular to a bowel-relaxing oral liquid which comprises the following raw material components by weight: 180g of radix rehmanniae, 180g of radix rehmanniae preparata, 36g of radix aconiti carmichaeli, 36g of cortex cinnamomi, 90g of angelica sinensis, 90g of fructus aurantii immaturus, 36g of cortex magnoliae officinalis, 72g of radix achyranthis bidentatae, 180g of radix paeoniae alba and 120g of herba cistanche. The bowel-relaxing oral liquid can obviously improve the excrement quality, relieve the discomfort of the anus during defecation and shorten the defecation time interval and the defecation time of each time; the traditional Chinese medicine composition has a remarkable curative effect on senile body fluid deficiency type habitual constipation and postoperative and postpartum blood deficiency type habitual constipation.

Description

Technical Field

[0001] The present invention relates to the field of medicine, and particularly to a laxative oral liquid and a preparation method thereof. Background Art

[0002] Constipation is a common symptom of digestive system diseases and belongs to intestinal diseases. It refers to the condition where due to abnormal conduction of the large intestine, the stool becomes dry and hard, the defecation cycle is prolonged; or although the defecation cycle is not long, the feces are dry and hard and difficult to excrete; or the feces are not hard, but there is a feeling of defecation, but the defecation is not smooth. In "Huangdi Neijing", it has been recognized that constipation is related to the spleen and stomach being affected by cold, heat in the intestine, etc. Zhang Zhongjing had a relatively comprehensive understanding of constipation and put forward different pathogenesis of cold, heat, deficiency and excess. The location of the disease of constipation is in the large intestine, which is due to abnormal conduction of the large intestine, but it is often related to the dysfunction of the spleen, stomach, liver and kidney. The stomach is connected to the intestine. Excessive heat in the stomach is transmitted downward to the large intestine, burning and consuming body fluids. Excessive heat in the large intestine causes dry feces to accumulate. The general principle of modern medicine for treating habitual constipation is catharsis. Chronic habitual constipation patients often rely on cathartic drugs or even enemas to defecate, which further weakens the stress ability of the intestinal mucosa and makes constipation more serious. At present, there are already many Chinese and Western laxative drugs (such as: Maren Pills, Aloe Vera Capsules, Intestine-Clearing Tea, Polyethylene Glycol Electrolyte Powder, etc.), but due to large side effects, some patients cannot take them for a long time.

[0003] Oral liquid is based on traditional Chinese medicine decoction, extracts the effective components of the medicine, adds adjuvants such as flavoring agents and bacteriostatic agents, and is made into a sterile or semi-sterile oral liquid according to the ampoule filling and sealing process of injections. At present, the production of oral liquids is diversified, so they have different effects. Commonly, they have the function of moistening the intestine and relieving constipation. As a result, there are many existing oral liquids for moistening the intestine and relieving constipation, and the product types are diverse. However, their health care effects are different, and some have higher manufacturing costs, and some production processes are more complex, which cannot well meet the needs of different people. Summary of the Invention

[0004] Aiming at the technical problems in the above-mentioned prior art that constipation patients have large side effects by taking cathartic drugs, etc., and the extraction process of laxative oral liquid is complex and costly.

[0005] To solve the above problems, the present application provides a laxative oral liquid, and the raw materials of the oral liquid are raw rehmannia root, prepared rehmannia root, aconite, cinnamon, angelica sinensis, immature bitter orange, magnolia officinalis, achyranthes bidentata, white peony root, and cistanche deserticola.

[0006] Specifically, the weight ratio of each raw material component in the oral liquid is: 180 g of raw rehmannia root, 180 g of prepared rehmannia root, 36 g of aconite, 36 g of cinnamon, 90 g of angelica sinensis, 90 g of immature bitter orange, 36 g of magnolia officinalis, 72 g of achyranthes bidentata, 180 g of white peony root, and 120 g of cistanche deserticola.

[0007] A preparation method of a laxative oral liquid includes the following steps: S1: Take 180g of Radix Rehmanniae, 180g of Rehmanniae Preparata, 36g of Radix Aconiti Lateralis, 36g of Cinnamon Bark, 90g of Radix Angelicae Sinensis, 90g of Fructus Aurantii Immaturus, 36g of Magnolia Officinalis, 72g of Achyranthes Bidentatae, 180g of Paeonia lactiflora, 120g of Cistanche Deserticola, add 10 times the amount of water and decoct for 150min to extract the solution; S2: Add 8 times the amount of water to the filtered medicinal residue and decoct for 120 minutes to extract the solution; S3: The solutions extracted from S1 and S2 are mixed and concentrated under negative pressure; S4: adding a preservative to the concentrated solution and then packaging; S5: Sterilize the packaged solution bag at 110°C for 30 minutes.

[0008] The pharmacological effects of each Chinese medicine are as follows: Raw Rehmannia is sweet, bitter and cold in nature, and enters the heart, liver and kidney meridians. It has the effects of clearing away heat and cooling blood, nourishing yin and promoting body fluid.

[0009] Rehmannia glutinosa is sweet and slightly warm in nature. It enters the liver and kidney meridians. It has the effects of nourishing blood and yin, replenishing essence and marrow, nourishing kidney yin, and moistening the intestines and promoting bowel movements.

[0010] Aconite is pungent, sweet, and very hot. It enters the heart, kidney, and spleen meridians. It has the effects of restoring yang and rescuing adverse conditions, replenishing fire and aiding yang, and dispelling cold and relieving pain.

[0011] Cinnamon is pungent, sweet, and very hot. It enters the spleen, kidney, heart, and liver meridians. It has the functions of replenishing fire and supporting yang, dispelling cold and relieving pain, warming the meridians and dredgeing blood vessels, and guiding fire back to the origin.

[0012] Angelica sinensis is sweet, pungent and warm, and enters the liver, heart and spleen meridians. White peony root is bitter, sour and slightly cold, and enters the liver and spleen meridians, and moistens the intestines and promotes bowel movements.

[0013] Citrus aurantium, bitter, pungent, sour, warm, enters the spleen, stomach and large intestine meridians.

[0014] Magnolia officinalis is bitter, pungent and warm. It enters the spleen, stomach, lung and large intestine meridians. It promotes qi and relieves bloating, and relaxes the intestines and promotes bowel movements.

[0015] Achyranthes bidentata is bitter, sweet and sour, and neutral in nature. It enters the liver and kidney meridians. It can tonify the liver and kidneys, strengthen the waist and knees, and has a downward nature.

[0016] White peony root is bitter, sour and slightly cold. It enters the liver and spleen meridians, moistening the intestines and promoting bowel movements.

[0017] Cistanche deserticola is sweet, salty and warm. It enters the kidney and large intestine meridians. It has the effects of replenishing kidney yang, moistening the intestines and promoting bowel movements.

[0018] The beneficial effects of the present invention are: The laxative oral liquid in the present application can significantly improve stool quality, relieve anal discomfort during defecation, shorten the defecation time interval and the duration of each defecation; it has a significant effect on habitual constipation of the elderly with body fluid deficiency type and postoperative and postpartum blood deficiency type.

[0019] The oral liquid prepared by the method of the present invention has simple manufacturing processes and equipment, resulting in a relatively low manufacturing cost of the oral liquid. It is suitable for large-scale production and can improve the efficiency of enterprises. Description of the Drawings

[0020] Figure 1 It is the process flow chart of the present invention. Detailed Embodiments

[0021] In order to enable those of ordinary skill in the art to better understand the technical solution of the present invention, the technical solution of the present invention will be further described below through embodiments. Embodiment 1

[0022] A preparation method of a laxative oral liquid includes the following steps: S1: Take 180 g of Rehmannia glutinosa, 180 g of Rehmannia glutinosa preparata, 36 g of Aconitum carmichaelii, 36 g of Cinnamomum cassia, 90 g of Angelica sinensis, 90 g of Fructus aurantii immaturus, 36 g of Magnolia officinalis, 72 g of Achyranthes bidentata, 180 g of Paeonia lactiflora, and 120 g of Cistanche deserticola, add 10 times the amount of water, and decoct for 150 min to obtain an extraction solution; S2: Add 8 times the amount of water to the filtered medicinal residues and decoct for 120 min to obtain an extraction solution; S3: Mix the solutions extracted in S1 and S2 and concentrate under negative pressure; S4: Add a preservative to the concentrated solution and then carry out sub-packaging; S5: Sterilize the sub-packaged solution package at 110 °C for 30 min.

[0023] Specifically, the preservative added in S4 is sodium benzoate. Embodiment 2

[0024] A preparation method of a laxative oral liquid includes the following steps: S1: Take 36 g of Cinnamomum cassia, 90 g of Angelica sinensis, 90 g of Fructus aurantii immaturus, and 36 g of Magnolia officinalis to distill and extract volatile oils; S2: Add 10 times the amount of water to the medicinal residues after distillation, together with 180 g of Rehmannia glutinosa, 180 g of Rehmannia glutinosa preparata, 36 g of Aconitum carmichaelii, 72 g of Achyranthes bidentata, 180 g of Paeonia lactiflora, and 120 g of Cistanche deserticola, and decoct for 150 min to obtain an extraction solution; Extract continuously for 3 times, each time for 1.5 hours, and combine the extraction solutions; S3: Filter and concentrate the solution obtained in S2; S4: Add honey and the volatile oils obtained in S1 to the solution concentrated in S3; S5: Sterilize the sub-packaged solution package at 110 °C for 30 min.

[0025] It should be noted that the above filtration processes are all carried out using a sieve with a mesh size of 80 - 120 for filtering the medicinal liquid.

[0026] Rule of law Shengdi is sweet, bitter and cold in nature, and enters the heart, liver and kidney meridians. It has the effects of clearing heat and cooling blood, nourishing yin and promoting body fluid. Shudi is sweet and slightly warm in nature, and enters the liver and kidney meridians. It has the effects of nourishing blood and yin, replenishing essence and benefiting marrow. Shengdi and Shudi are both monarch medicines, which nourish kidney yin, moisten the intestines and relieve constipation, and the intention is to "seek yang in yin", that is, to nourish kidney yang with products that nourish yin and replenish essence, so as to have the effect of nourishing original yang.

[0027] Aconite, pungent, sweet, very hot, enters the heart, kidney, spleen meridians, and has the functions of restoring yang and rescuing adverse conditions, replenishing fire and supporting yang, dispersing cold and relieving pain. Cinnamon, pungent, sweet, very hot, enters the spleen, kidney, heart, and liver meridians, and has the functions of replenishing fire and supporting yang, dispersing cold and relieving pain, warming the meridians and unblocking the vessels, and guiding fire back to the origin. Aconite and cinnamon are both ministers, and the dosage is small. They warm and nourish the yang in the kidney, and are intended to slightly grow a little fire to generate kidney qi.

[0028] Cistanche deserticola is sweet, salty, and warm in nature. It enters the kidney and large intestine meridians and has the effect of tonifying kidney yang and moistening the intestines and promoting bowel movements. Achyranthes bidentata is bitter, sweet, and sour in nature and is neutral in nature. It enters the liver and kidney meridians and can tonify the liver and kidneys, strengthen the waist and knees, and has a downward nature.

[0029] Angelica sinensis is sweet, pungent, and warm, and enters the liver, heart, and spleen meridians. White peony root is bitter, sour, and slightly cold, and enters the liver and spleen meridians. The combination of Angelica sinensis and white peony root can nourish blood and harmonize blood, and moisten the intestines and promote bowel movements.

[0030] Citrus aurantium, bitter, pungent, sour, warm, enters the spleen, stomach, and large intestine meridians. Magnolia officinalis, bitter, pungent, warm, enters the spleen, stomach, lung, and large intestine meridians. Citrus aurantium and Magnolia officinalis both promote qi and relieve bloating, and widen the intestine and promote bowel movements.

[0031] Cistanche, Achyranthes bidentata, Chinese angelica, white peony root, immature bitter orange and Magnolia officinalis are used as adjuvant drugs to help the main drugs warm and nourish the kidney yang, guide the fire back to the origin, nourish the blood, moisten the intestines and promote bowel movements.

[0032] Typical Cases Wang, male, 50 years old, with no history of herbal medicine allergy. He visited on July 21, 2023. Chief complaint: Difficult defecation for 1 month. Current medical history: The patient reported that he would experience difficult defecation every summer, and felt that it was more severe this year than before. Difficult defecation occurred 1 month ago without obvious cause, and taking "probiotics" orally by himself was ineffective. Current symptoms: Loose stools, sticky, difficult defecation, once a day, occasionally with dry stool heads. Two days ago, due to improper diet, there was distension in the epigastric region, occasional acid reflux, normal appetite, normal urination, average night rest, fear of cold, cold hands and feet in winter, hot palms and soles in summer, and increased sweating. Past medical history: Cervical spondylosis, hypothyroidism caused by Hashimoto's thyroiditis, usually taking "Euthyrox" for treatment. Allergy history: Denied. Physical examination: Conscious, in good spirits, no obvious abnormalities were seen in the skin and mucous membranes, superficial lymph nodes were not palpable, and no obvious abnormalities were found in the head and neck, chest, heart, lungs and abdomen examinations. Physiological reflexes were present, and pathological reflexes were not elicited. No obvious abnormalities were found in the specialized physical examination. Tongue diagnosis: Pale tongue, white coating. Pulse diagnosis: Deep. Diagnosis: Constipation (yang deficiency syndrome). Treatment method: Focus on warming yang and tonifying the kidney, guiding fire back to its origin, nourishing blood and moistening the intestines for defecation. After taking the defecation oral liquid in this application for 1 month, review. On August 21, 2023, during the follow-up visit, the patient reported that the stools were basically formed after taking the medicine for 1 month, the distension in the epigastric region improved, and still had fear of cold. Diagnosis: Constipation (yang deficiency syndrome). Doctor's advice: Continue taking the medicine for 1 month. The phone follow-up visit reported that the stools were smooth and not dry again.

[0033] II. Li, female, 55 years old. She visited on May 10, 2023. Chief complaint: Dry stools for more than 2 years. The patient has had repeated difficulty in defecating dry stools for 2 years, once every 5 - 7 days, accompanied by abdominal distension, belching, and poor appetite. Usually, the whole body is afraid of cold. Tongue diagnosis: Pale red tongue, white coating. Pulse diagnosis: Deep and thready. She had a previous physical examination, and colonoscopy showed no obvious abnormalities. Diagnosis: Constipation (yang deficiency syndrome). Treatment method: Focus on warming yang and tonifying the kidney, guiding fire back to its origin, nourishing blood and moistening the intestines for defecation. Take the defecation oral liquid orally for 2 weeks. On May 24, 2023, during the follow-up visit, the patient reported that the stools were softer and easier to excrete after taking this medicine, once every 3 days, the abdominal distension improved, and the appetite increased. Diagnosis: Constipation (yang deficiency syndrome). Doctor's advice: Continue taking the medicine for 1 month. The phone follow-up visit reported that the stools were smooth and not dry again.

[0034] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

Claims

1. A laxative oral liquid, characterized in that: The raw materials of the oral liquid are raw rehmannia, cooked rehmannia, aconite root, cinnamon bark, angelica root, immature bitter orange, magnolia bark, Achyranthes bidentata, white peony root and Cistanche deserticola.

2. A laxative oral liquid according to claim 1, characterized in that: The weight ratio of each raw material component in the oral liquid is: 180g of raw rehmannia, 180g of cooked rehmannia, 36g of aconite, 36g of cinnamon, 90g of angelica, 90g of immature bitter orange, 36g of Magnolia officinalis, 72g of Achyranthes bidentata, 180g of white peony root, and 120g of Cistanche deserticola.

3. The method for preparing a laxative oral liquid as claimed in claim 2, characterized in that: The following steps are involved: S1: Take 180g of Radix Rehmanniae, 180g of Rehmanniae Preparata, 36g of Radix Aconiti Lateralis, 36g of Cinnamon Bark, 90g of Radix Angelicae Sinensis, 90g of Fructus Aurantii Immaturus, 36g of Magnolia Officinalis, 72g of Achyranthes Bidentatae, 180g of Paeonia lactiflora, 120g of Cistanche Deserticola, add 10 times the total weight of the drugs in water and decoct for 150min to extract the solution; S2: Add 8 times the amount of water to the filtered medicinal residue and decoct for 120 minutes to extract the solution; S3: The solutions extracted from S1 and S2 are mixed and concentrated under negative pressure; S4: adding a preservative to the concentrated solution and then packaging; S5: Sterilize the packaged solution bag at 110°C for 30 minutes.

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