Traditional Chinese medicine preparation for treating orthopedic diseases as well as preparation method and application of traditional Chinese medicine preparation

Abstract

The invention discloses a traditional Chinese medicine preparation for treating orthopedic diseases. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 9-15 parts of rhizoma drynariae, 8-16 parts of cortex eucommiae, 6-13 parts of radix morindae officinalis, 9-16 parts of fructus lycii, 9-17 parts of semen cuscutae, 7-13 parts of radix trichosanthis, 6-14 parts of radix angelicae sinensis, 10-12 parts of caulis spatholobi and 18-23 parts of artificial tiger bone powder. The traditional Chinese medicine preparation is a pure traditional Chinese medicine preparation, achieves the effects of activating blood and strengthening bones, activating meridians to stop pain and accelerating bone healing under the interaction of the raw materials, is used for treating various orthopedic diseases such as femoral head necrosis, fracture and hairline fracture, and has the characteristics of quick effect, high cure rate, no relapse after cure, no toxic or side effect and capability of treating both symptoms and root causes; the taking is convenient and safe.

Description

Technical Field

[0001] The present invention relates to the technical field of orthopedics, and particularly relates to a traditional Chinese medicine preparation for treating orthopedic diseases, a preparation method thereof, and an application thereof. Background Art

[0002] Orthopedics is one of the most common departments in major hospitals, mainly studying the anatomy, physiology, and pathology of the musculoskeletal system, and using drugs, surgery, and physical methods to maintain and develop the normal form and function of this system.

[0003] However, in the prior art, for osteonecrosis of the femoral head, fractures, bone fractures, etc. in orthopedics, during the healing and recovery process, not only does the healing take a long time, but it also easily causes relatively high pain, making patients need to take painkillers. Most of the drugs are Western medicines, such as ibuprofen and painkillers. Although the clinical effect is good, the side effects are relatively large, and they cannot play a radical role. The disease recurs after stopping the drug, and some drugs are relatively expensive, and long-term use increases the economic burden on patients and also has an adverse impact on their bodies. Summary of the Invention

[0004] The present invention provides a traditional Chinese medicine preparation for treating orthopedic diseases, a preparation method thereof, and an application thereof to solve the problems raised in the above background art.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] A traditional Chinese medicine preparation for treating orthopedic diseases is composed of the following raw materials in parts by weight: 9 - 15 parts of Drynaria rhizome, 8 - 16 parts of Eucommia ulmoides, 6 - 13 parts of Morinda officinalis, 9 - 16 parts of Lycium barbarum, 9 - 17 parts of Cuscuta chinensis, 7 - 13 parts of Trichosanthes kirilowii root, 6 - 14 parts of Angelica sinensis, 10 - 12 parts of Spatholobus suberectus, and 18 - 23 parts of artificial tiger bone powder.

[0007] As a further improvement of this technical solution: it is composed of the following raw materials in parts by weight: 11 parts of Drynaria rhizome, 10 parts of Eucommia ulmoides, 9 parts of Morinda officinalis, 11 parts of Lycium barbarum, 9 parts of Cuscuta chinensis, 10 parts of Trichosanthes kirilowii root, 10 parts of Angelica sinensis, 10 parts of Spatholobus suberectus, and 20 parts of artificial tiger bone powder.

[0008] As a further improvement of this technical solution: it is composed of the following raw materials in parts by weight: 15 parts of Drynaria rhizome, 12 parts of Eucommia ulmoides, 8 parts of Morinda officinalis, 10 parts of Lycium barbarum, 9 parts of Cuscuta chinensis, 10 parts of Trichosanthes kirilowii root, 8 parts of Angelica sinensis, 10 parts of Spatholobus suberectus, and 18 parts of artificial tiger bone powder.

[0009] As a further improvement of this technical solution: it is composed of the following raw materials in parts by weight: 11 parts of Drynaria rhizome, 9 parts of Eucommia ulmoides, 13 parts of Morinda officinalis, 11 parts of Lycium barbarum, 9 parts of Cuscuta chinensis, 8 parts of Trichosanthes kirilowii root, 8 parts of Angelica sinensis, 12 parts of Spatholobus suberectus, and 19 parts of artificial tiger bone powder.

[0010] A preparation method of a traditional Chinese medicine preparation for treating orthopedic diseases, comprising the following steps:

[0011] (1) Raw material treatment: Remove impurities from various raw material components, cut them into sections, and then dry them, and weigh them according to the weight parts in each of the above traditional Chinese medicine preparations;

[0012] (2) Decoction: After mixing the raw materials of each traditional Chinese medicine preparation respectively, add water with a weight 8 times that of the raw materials, soak at 60 °C for 1 hour, then boil and reflux for 1 hour, filter to obtain the medicinal liquid and medicinal residues respectively. In the said medicinal residues, add water with a weight 6 times that of the residues, heat and reflux for 40 minutes, and combine the filtered medicinal liquid with the medicinal liquid obtained from the first filtration;

[0013] (3) Concentration and extraction: Concentrate the mixed medicinal liquid obtained in step (2) to a density of 1.0 - 1.1 g / cm³ at -0.07 to -0.08 MPa and 70 - 90 °C, then perform alcohol precipitation extraction to obtain the traditional Chinese medicine stock solution, and prepare the traditional Chinese medicine stock solution into a traditional Chinese medicine preparation.

[0014] As a further improvement of this technical solution: The application of the traditional Chinese medicine preparation in the preparation of drugs for treating orthopedic diseases.

[0015] As a further improvement of this technical solution: The application of the traditional Chinese medicine preparation in the preparation of drugs for treating femoral head necrosis.

[0016] As a further improvement of this technical solution: The application of the traditional Chinese medicine preparation in the preparation of drugs for treating fractures.

[0017] As a further improvement of this technical solution: The application of the traditional Chinese medicine preparation in the preparation of drugs for treating bone fractures.

[0018] Compared with the prior art, the beneficial effects of the present invention are:

[0019] The present invention is a pure traditional Chinese medicine preparation. Under the interaction of various raw materials, the drug achieves the effects of promoting blood circulation to strengthen bones, dredging collaterals to relieve pain, and accelerating bone healing. It is used for the treatment of various orthopedic diseases such as femoral head necrosis, fractures, and bone fractures, and has the characteristics of quick effect, high cure rate, no recurrence after cure, no toxic and side effects, treating both the symptoms and the root causes, and being convenient and safe to take.

[0020] The above description is only an overview of the technical solution of the present invention. In order to be able to more clearly understand the technical means of the present invention and implement it according to the content of the description, the following will be described in detail with reference to the preferred embodiments of the present invention and the accompanying drawings. The specific implementation manners of the present invention are given in detail by the following embodiments and their accompanying drawings. Brief Description of the Drawings

[0021] The accompanying drawings described herein are used to provide a further understanding of the present invention and form a part of this application. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0022] Figure 1 It is a schematic diagram of the preparation method of a traditional Chinese medicine preparation for treating orthopedic diseases proposed by the present invention. Detailed implementation manners

[0023] The principles and features of the present invention will be described below with reference to the accompanying drawings. The examples given are only for explaining the present invention and are not intended to limit the scope of the present invention. The present invention will be described more specifically by way of example in the following paragraphs with reference to the accompanying drawings. The advantages and features of the present invention will be clearer according to the following description and the claims. It should be noted that the drawings are all in a very simplified form and use non-precise scales, only for the purpose of facilitating and clearly assisting in explaining the purpose of the embodiments of the present invention.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the technical field to which the present invention belongs. The terms used in the description of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0025] Example 1:

[0026] In the embodiment of the present invention, a traditional Chinese medicine preparation for treating orthopedic diseases is composed of the following raw materials in parts by weight: 11 parts of drynaria rhizome, 10 parts of eucommia bark, 9 parts of morinda officinalis, 11 parts of wolfberry fruit, 9 parts of dodder seed, 10 parts of trichosanthes root, 10 parts of angelica sinensis, 10 parts of millettia reticulata and 20 parts of artificial tiger bone powder.

[0027] The above traditional Chinese medicine composition is made into a traditional Chinese medicine preparation, including the following steps:

[0028] (1) Raw material treatment: Remove impurities and cut into sections for each raw material component, and then dry them, and weigh them according to the weight parts in each of the above traditional Chinese medicine preparations;

[0029] (2) Decoction: After mixing the raw materials of each traditional Chinese medicine preparation respectively, add 8 times the weight of water, soak at 60 °C for 1 hour, then boil and reflux for 1 hour, filter to obtain the medicinal liquid and the medicinal residues respectively. In the medicinal residues, add 6 times the weight of water, heat and reflux for 40 minutes, and merge the filtered medicinal liquid with the medicinal liquid obtained by the first filtration;

[0030] (3) Concentration and extraction: Concentrate the mixed medicinal liquid obtained in step (2) to a density of 1.0 - 1.1 g / cm³ at -0.07 to -0.08 MPa and 70 - 90 °C, then perform alcohol precipitation extraction to obtain the original Chinese medicine liquid, and prepare the original Chinese medicine liquid into a Chinese medicine preparation.

[0031] Example 2:

[0032] In the embodiment of the present invention, a Chinese medicine preparation for treating orthopedic diseases is composed of the following raw materials in parts by weight: 15 parts of Drynaria rhizome, 12 parts of Eucommia ulmoides, 8 parts of Morinda officinalis, 10 parts of Lycium barbarum, 9 parts of Cuscuta chinensis, 10 parts of Trichosanthes kirilowii, 8 parts of Angelica sinensis, 10 parts of Spatholobus suberectus, and 18 parts of artificial tiger bone powder.

[0033] To prepare the above Chinese medicine composition into a Chinese medicine preparation, the following steps are included:

[0034] (1) Raw material treatment: Remove impurities from various raw material components, cut them into sections, and then dry them, and weigh them according to the weight parts in the above Chinese medicine preparations.

[0035] (2) Decoction: After mixing the raw materials of each Chinese medicine preparation respectively, add 8 times the weight of water, soak at 60 °C for 1 hour, then boil and reflux for 1 hour, filter to obtain the medicinal liquid and the medicinal residues respectively. In the medicinal residues, add 6 times the weight of water, heat and reflux for 40 minutes, and merge the filtered medicinal liquid with the medicinal liquid obtained from the first filtration.

[0036] (3) Concentration and extraction: Concentrate the mixed medicinal liquid obtained in step (2) to a density of 1.0 - 1.1 g / cm³ at -0.07 to -0.08 MPa and 70 - 90 °C, then perform alcohol precipitation extraction to obtain the original Chinese medicine liquid, and prepare the original Chinese medicine liquid into a Chinese medicine preparation.

[0037] Example 3:

[0038] In the embodiment of the present invention, a Chinese medicine preparation for treating orthopedic diseases is composed of the following raw materials in parts by weight: 11 parts of Drynaria rhizome, 9 parts of Eucommia ulmoides, 13 parts of Morinda officinalis, 11 parts of Lycium barbarum, 9 parts of Cuscuta chinensis, 8 parts of Trichosanthes kirilowii, 8 parts of Angelica sinensis, 12 parts of Spatholobus suberectus, and 19 parts of artificial tiger bone powder.

[0039] To prepare the above Chinese medicine composition into a Chinese medicine preparation, the following steps are included:

[0040] (1) Raw material treatment: Remove impurities from various raw material components, cut them into sections, and then dry them, and weigh them according to the weight parts in the above Chinese medicine preparations.

[0041] (2) Decoction: After mixing the raw materials of each traditional Chinese medicine preparation respectively, add water with a weight 8 times that of the raw materials, soak at 60°C for 1 hour, then boil and reflux for 1 hour, filter to obtain the medicinal liquid and medicinal residues respectively. In the said medicinal residues, add water with a weight 6 times that of the residues, heat and reflux for 40 minutes, and merge the filtered medicinal liquid with the medicinal liquid obtained from the first filtration;

[0042] (3) Concentration and extraction: Concentrate the mixed medicinal liquid obtained in step (2) to a density of 1.0 - 1.1 g / cm³ at -0.07 to -0.08 MPa and 70 - 90°C, then perform alcohol precipitation extraction to obtain the original traditional Chinese medicine liquid, and prepare the said original traditional Chinese medicine liquid into a traditional Chinese medicine preparation.

[0043] 1. Case selection

[0044] First, select a total of 40 patients with osteonecrosis of the femoral head, fractures or bone fractures, and then divide them into 4 groups, namely group 1, group 2, group 3, and group 4, with 10 people in each group for a total of four experimental groups.

[0045] 2. Administration method

[0046] For groups 1, 2, and 3, the experimental groups respectively use the products of Examples 1 - 3 of the present invention, twice a day, take it with warm water half an hour before meals, and take it continuously for 15 days. The fourth group is the control group, which does not take the medicine of the present invention, but uses western medicines such as Sanqi Shangyao Tablets commonly used in the market.

[0047] 3. Test results

[0048] After systematic clinical observation and statistical analysis, the summary is as follows:

[0049] I. Clinical manifestations

[0050] 1. Diagnosis by CT and X-ray film in the hospital.

[0051] 2. Relevant test reports.

[0052] 3. Pain and tenderness: Pain in joints and cervical vertebrae with direct or indirect tenderness.

[0053] II. Efficacy judgment criteria

[0054] Marked effect: It refers to those who meet one of the following: 1. Most of the sensory disorders return to normal; 2. Muscle appearance and muscle strength partially return to normal; 3. Most of the autonomic nerve function disorders return to normal; 4. Pathological reflex disappears.

[0055] Effective: It refers to those who meet one of the following: 1. Some of the subjective symptoms improve, or the affected limb feels strong and flexible; 2. Some of the sensory disorders improve; 3. Some of the autonomic nerve function disorders improve.

[0056] Ineffective: No change in various symptoms and signs.

[0057] III. The treatment results after half a month of medication are shown in Table 1.

[0058] Table 1

[0059]

[0060] The clinical treatment effects show that Examples 1-3 of the present invention are superior to Control Group 4. The total effective rate of the pharmaceutical preparations provided in Examples 1-3 of the present invention for treating orthopedic diseases is above 80%, and the pain of patients after taking the products of Examples 1-3 is significantly lower than that of Control Group 4.

[0061] The above are only the preferred embodiments of the present invention, and do not impose any form of limitation on the present invention. Any person skilled in the art can smoothly implement the present invention according to the illustrations in the specification and the above description. However, any equivalent changes such as slight modifications, evolutions made by those skilled in the art within the scope of the technical solution of the present invention by using the technical content disclosed above are equivalent embodiments of the present invention. At the same time, any equivalent changes, modifications, and evolutions made to the above embodiments based on the substantial technology of the present invention still fall within the protection scope of the technical solution of the present invention.

Claims

1. A Chinese medicine preparation for treating orthopedic diseases, characterized in that: The invention is composed of the following raw materials in parts by weight: 9-15 parts of Drynaria fortunei, 8-16 parts of Eucommia ulmoides, 6-13 parts of Morinda officinalis, 9-16 parts of Lycium barbarum, 9-17 parts of Cuscuta australis, 7-13 parts of Radix Trichosanthis, 6-14 parts of Angelica sinensis, 10-12 parts of Millettia spatholobi and 18-23 parts of artificial tiger bone powder.

2. A Chinese medicine preparation for treating orthopedic diseases according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 11 parts of Drynariae Rhizoma, 10 parts of Eucommia ulmoides, 9 parts of Morinda officinalis, 11 parts of Lycium barbarum, 9 parts of Cuscuta australis, 10 parts of Radix Trichosanthis, 10 parts of Angelica sinensis, 10 parts of Millettia spatholobi and 20 parts of artificial tiger bone powder.

3. A Chinese medicine preparation for treating orthopedic diseases according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 15 parts of Drynariae Rhizoma, 12 parts of Eucommia ulmoides, 8 parts of Morinda officinalis, 10 parts of Lycium barbarum, 9 parts of Cuscuta australis, 10 parts of Radix Trichosanthis, 8 parts of Angelica sinensis, 10 parts of Millettia spatholobi and 18 parts of artificial tiger bone powder.

4. A Chinese medicine preparation for treating orthopedic diseases according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 11 parts of Drynariae Rhizoma, 9 parts of Eucommia ulmoides, 13 parts of Morinda officinalis, 11 parts of Lycium barbarum, 9 parts of Cuscuta australis, 8 parts of Radix Trichosanthis, 8 parts of Angelica sinensis, 12 parts of Millettia spatholobi and 19 parts of artificial tiger bone powder.

5. A method for preparing a Chinese medicine preparation for treating orthopedic diseases according to any one of claims 1 to 4, characterized in that: It consists of the following steps: (1) Raw material processing: remove impurities from various raw material components, cut them into sections, and then dry them, and weigh them according to the weight proportions in the above-mentioned Chinese medicine preparations; (2) decoction: after mixing the raw materials of each Chinese medicine preparation, add 8 times the weight of water, soak at 60°C for 1 hour, then boil and reflux for 1 hour, filter to obtain the medicinal liquid and the medicinal residue, add 6 times the weight of water to the medicinal residue, heat and reflux for 40 minutes, and combine the filtered medicinal liquid with the medicinal liquid obtained by the first filtration; (3) Concentration and extraction: The mixed medicinal solution obtained in step (2) is concentrated at -0.07 to -0.08 MPa and 70 to 90°C to a density of 1.0 to 1.1 g / cm3, and then subjected to alcohol precipitation extraction to obtain a Chinese medicine stock solution, which is then prepared into a Chinese medicine preparation.

6. Use of the Chinese medicine preparation according to any one of claims 1 to 4 in the preparation of drugs for treating orthopedic diseases.

7. Use of the Chinese medicine preparation as described in any one of claims 1 to 4 in preparing drugs for treating femoral head necrosis.

8. Use of the Chinese medicine preparation according to any one of claims 1 to 4 in preparing medicine for treating fractures.

9. Use of the Chinese medicine preparation as claimed in any one of claims 1 to 4 in preparing medicine for treating bone fracture.

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