Novel medicinal and edible traditional Chinese medicine composition capable of reducing blood sugar and preparation method of novel medicinal and edible traditional Chinese medicine composition

Abstract

The invention provides a novel medicinal and edible blood sugar reducing traditional Chinese medicine composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions, and the novel medicinal and edible blood sugar reducing traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of grapefruit, 5-10 parts of litchi, 5-10 parts of guava, 3-8 parts of mulberry, 3-10 parts of wolfberry, 12-15 parts of radix trichosanthis, 5-10 parts of radix puerariae, 5-10 parts of codonopsis pilosula and 3-8 parts of radix scrophulariae. Most of the raw materials used in the invention are edible and medicinal, have small toxicity, overcome the toxic and side effects of other hypoglycemic drugs, especially western medicines, and especially overcome the disadvantage of damage to liver and kidney after long-term use of western medicines, have no toxic and side effects in long-term test use, are safe when being used according to daily dose and treatment course, and cooperate with each other to complement each other, and have no toxic and side effects. All the medicines are combined to enhance the curative effect and treat both symptoms and root causes.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and particularly relates to a novel hypoglycemic traditional Chinese medicine composition for both medicine and food and a preparation method thereof. Background Art

[0002] Diabetes is also known as consumptive thirst in traditional Chinese medicine. The incidence of this disease is very high all over the world and is increasing year by year. The clinical manifestations of this disease are that patients drink a lot, urinate a lot, eat a lot and are emaciated. The term "consumptive thirst" first appeared in "Huangdi Neijing". In "Shuowen Jiezi", "xiao" means consumption and dissipation; the original meaning of "ke" is exhaustion, the same as "jie", and the water is dried up. Here, the main thing is to distinguish the different appellations when the term "consumptive thirst" is used as a disease name. Looking at medical records of all dynasties, the similar appellations mainly include: consumptive thirst, triple consumptive thirst, lung consumptive thirst, consumptive impediment, diaphragmatic consumptive thirst, middle consumptive thirst, kidney consumptive thirst and renal consumptive thirst, etc. In the era of "Huangdi Neijing", there was already an understanding of consumptive thirst disease, and both the etiology, pathogenesis, clinical symptoms and treatment prognosis were elaborated. Regarding its etiology, it was considered that overeating fatty and sweet foods, emotional disorders, excessive fatigue, and weak internal organs; and heat binding in the gastrointestinal tract and consuming body fluids were its pathogenesis. There were also clear descriptions of the characteristic symptoms such as excessive drinking, excessive urination, excessive eating and emaciation. In the Han Dynasty, Zhang Zhongjing specifically discussed the methods for treating consumptive thirst disease, with prescriptions and theories. In "Synopsis of the Golden Chamber", it was considered that stomach heat and kidney deficiency were the main causes of consumptive thirst disease. Specific treatment prescriptions were proposed: White Tiger Decoction plus Ginseng, Clam Powder Powder, Kidney Qi Pill, etc. In the Sui and Tang dynasties, traditional Chinese medicine's understanding of consumptive thirst disease was further improved. Chao Yuanfang classified consumptive thirst disease into 8 types such as consumptive thirst syndrome, consumptive disease syndrome, consumptive thirst with deficiency and death syndrome, etc., and also proposed exercise therapy for this disease. In the Song, Jin and Yuan dynasties, there was a new understanding of this disease. Wang Huaiyin et al. in the Song Dynasty, in "Taiping Holy Prescriptions for Universal Relief", there was a volume of "Theory of Triple Consumptive Thirst", which divided "triple consumptive thirst" into upper, middle and lower energizers according to symptoms, "The so-called triple consumptive thirst, one is called consumptive thirst, the second is called middle consumptive thirst, and the third is called kidney consumptive thirst". Since Liu Hejian established the theory of triple consumptive thirst with dryness and heat in "Theory of Triple Consumptive Thirst", and Zhao Xianke established the theory of mainly treating the kidney for triple consumptive thirst, each formed a system. Chen Shiduo, Yu Chang and others also strongly advocated the view that treating consumptive thirst should be based on the kidney, and self-made "Combined Treatment Decoction", using 3 liang of Rehmannia glutinosa, 2 liang of Cornus officinalis, 2 liang of Ophiopogon japonicus, 5 qian of Plantago asiatica and 1 liang of Scrophularia ningpoensis, decocted in water for oral administration. This prescription nourishes the kidney and clears fire. They strongly advocated emphasizing that the consumptive syndrome is a fire syndrome and opposed using pungent and hot products such as aconite and cinnamon. Yu Chang pointed out in "Theory of Consumptive Thirst": "The suffering of consumptive thirst often starts subtly and becomes severe. It starts from the stomach and finally affects the lungs and kidneys", expounding that consumptive thirst disease finally ends in the kidney, so it is also emphasized to be based on the kidney.

[0003] Methods for treating consumptive thirst in traditional Chinese medicine include psychotherapy, diet control, food therapy, exercise therapy, acupuncture, and drug therapy. Among them, drug therapy is the main method. From "Huangdi Neijing" to "Qianjin Yaofang", although there is a classification method for the three types of consumptive thirst, most treatments used a single formula to govern all. Zhang Zhongjing in the Han Dynasty used Shenqi Pills to treat consumptive thirst with excessive urination. Sun Simiao in the Tang Dynasty mostly used herbs for nourishing yin and clearing heat, such as Rehmannia glutinosa, Coptis chinensis, Ophiopogon japonicus, and Limax flavus. In the Song Dynasty, "Huoren Shu" recorded the "main formula for treating all three types of consumptive thirst". Zhang Congzheng in the Jin Dynasty used the soup of boiling silkworm cocoons to mainly treat the three types of consumptive thirst, and the treatment of the three types of consumptive thirst separately had become a settled conclusion by the Qing Dynasty. Just as Cheng Zhongling said, "The symptoms of the three types of consumptive thirst are all due to the accumulation of dry heat. Generally, for treating the upper type, it is advisable to clear the lungs and also clear the stomach, with Erdong Decoction as the main formula. For treating the middle type, it is advisable to clear the stomach and also clear the kidneys, with Shengdi Bawu Decoction as the main formula. For treating the lower type, it is advisable to nourish the kidneys and also tonify the lungs, with Decoction of Rehmannia glutinosa and Shengmai Powder combined." This shows that although the three types of consumptive thirst are treated separately, the treatment cannot be completely separated, and the triple energizer should be taken into account. Due to the complexity and diversity of the causes of consumptive thirst disease, the clinical symptoms vary greatly, and the treatment methods are different. The following are summarized: ① The method of nourishing yin and clearing heat: Among the heat-clearing herbs, Coptis chinensis is most commonly used, followed by Gypsum fibrosum. ② The method of tonifying the kidneys, mostly using Liuwei Dihuang Pills, and sometimes Bawei Pills (warming and tonifying the kidney yang). ③ The method of strengthening the spleen, replenishing qi, and nourishing yin: mainly using formulas such as Buzhong Yiqi Decoction, Guipi Decoction, and Zhuye Huangqi Decoction. Add Schisandra chinensis and Ophiopogon japonicus to Buzhong Yiqi Decoction. Past medical experts mostly used herbs for clearing heat and promoting fluid production, nourishing yin and tonifying the kidneys, with Fangfengtongsheng Powder, Gypsum fibrosum, Dendrobium officinale, Paeonia lactiflora, Coix lacryma-jobi, Glycyrrhiza uralensis, Ophiopogon japonicus, Fructus gardeniae, Poria cocos, and Phragmites communis.

[0004] From scientific and technological literature, we have also found many reports on the treatment of diabetes with traditional Chinese medicine preparations. However, among the drug components we currently know, some have complex compositions, different treatment methods, some have high costs, some have insufficiently significant curative effects, and the effective components are not easy to control. Therefore, they are not suitable for promotion, especially not for large-scale industrial production.

[0005] Diabetes is mainly related to the three viscera of the spleen, lungs, and kidneys. The symptoms include excessive thirst with frequent drinking, voracious appetite, polyuria, and weight loss. Diabetes is also known as the three types of consumptive thirst syndrome. In the upper type, there is dry heat in the lungs, which burns body fluids, resulting in polyuria and thirst. In the middle type, there is accumulation of heat in the spleen and stomach, leading to voracious appetite. In the lower type, the kidney qi is not consolidated, and the ministerial fire is deficient, resulting in excessive drinking and polyuria and easy weight loss. Currently, diabetes is generally treated with Western medicine, but Western medicine treatment has relatively large side effects and the curative effect is not persistent. Severe diabetes patients need to rely on insulin injections to maintain. Therefore, it is necessary to design a new type of hypoglycemic traditional Chinese medicine composition that can be used as both medicine and food and its preparation method. Summary of the Invention

[0006] The purpose of the present invention is to provide a new type of hypoglycemic traditional Chinese medicine composition that can be used as both medicine and food and its preparation method, so as to solve the technical problem of the poor treatment effect of existing hypoglycemic traditional Chinese medicine.

[0007] To achieve the above purpose, the technical scheme adopted by the present invention is as follows:

[0008] A novel hypoglycemic traditional Chinese medicine composition for both food and medicine use, which is made from the following raw materials in parts by weight: 5 - 15 parts of pomelo, 5 - 10 parts of litchi, 5 - 10 parts of guava, 3 - 8 parts of mulberry, 3 - 10 parts of Chinese wolfberry, 12 - 15 parts of trichosanthes root, 5 - 10 parts of kudzu root, 5 - 10 parts of codonopsis pilosula, 3 - 8 parts of scrophularia ningpoensis.

[0009] Further, it is made from the following raw materials in parts by weight: 10 parts of pomelo, 8 parts of litchi, 8 parts of guava, 5 parts of mulberry, 8 parts of Chinese wolfberry, 13 parts of trichosanthes root, 8 parts of kudzu root, 8 parts of codonopsis pilosula, 5 parts of scrophularia ningpoensis.

[0010] Further, the litchi is sour litchi.

[0011] A preparation method of a novel hypoglycemic traditional Chinese medicine composition for both food and medicine use

[0012] (1) Juice the sour litchi and pomelo pulp with a juicer, filter the juice, and heat and concentrate it to obtain liquid A;

[0013] (2) Add 5 times the amount of water to mulberry, Chinese wolfberry, and guava, heat to boiling and extract with water twice, each time for 2 - 3 hours. Concentrate the water extract by heating, filter it to obtain water extract B;

[0014] (3) Chop trichosanthes root, kudzu root, codonopsis pilosula, and scrophularia ningpoensis, then put them into 5 times the amount of water, heat to boiling and extract with water twice, each time the boiling time is more than 4 hours. Concentrate the water extract by heating, filter it to obtain water extract C;

[0015] (4) Mix liquid A, liquid B, and liquid C, add 70 - 95% ethanol to precipitate, with the volume ratio of the mixed liquid: 70 - 95% ethanol = 1:3. After mixing, let it stand at 4℃ - 8℃ for 16 - 24 hours, filter to remove the precipitate to obtain liquid C;

[0016] (5) Recover ethanol. Put liquid C in an ethanol recovery device to recover ethanol, concentrate the recovered medicinal liquid by heating to obtain liquid D. Take liquid D, add appropriate syrup and excipients to obtain oral liquid, or continue to concentrate liquid D by heating to obtain liquid extract E, spray - dry it to obtain dry extract powder. Take dry extract powder F, mix it evenly with appropriate excipients to make granules, or add appropriate excipients to make capsules, tablets, long - acting capsules and other pharmaceutical dosage forms available in medicine.

[0017] Due to adopting the above - mentioned technical solution, the present invention has the following beneficial effects:

[0018] Most of the raw materials used in the present invention are both food and medicine, with low toxicity, overcoming the toxic and side effects of other hypoglycemic drugs, especially western medicines, especially the disadvantage of the damage to the liver and kidneys caused by long - term use of western medicines. No toxic and side effects have been found in long - term experimental use. Using the product of the present invention according to the daily dose and treatment course is safe. The drugs cooperate with each other, complement each other's advantages, and have a synergistic effect. All the drugs are used together to enhance the curative effect and treat both the symptoms and the root causes. Detailed Implementation Modes

[0019] To make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the following preferred embodiments are given to further elaborate on the present invention in detail. However, it should be noted that many details listed in the specification are only for enabling the reader to have a thorough understanding of one or more aspects of the present invention, and these aspects of the present invention can be implemented even without these specific details.

[0020] Embodiment 1:

[0021] Weigh the following traditional Chinese medicine components: (unit: g)

[0022] Acid litchi 5, pomelo 5, guava 6, mulberry 4, wolfberry 4, trichosanthes root 12, kudzu root 5, codonopsis pilosula 5, scrophularia root 3.

[0023] Its production steps are as follows:

[0024] 1. Take 5 g of acid litchi and 5 g of pomelo, squeeze the juice, filter the juice, and heat and concentrate it to obtain intermediate product A.

[0025] 2. Take 6 g of guava, 4 g of mulberry, and 4 g of wolfberry, add 5 times the amount of water, heat and boil for water extraction twice, 2 hours each time. Concentrate the water extraction solution, filter it to obtain intermediate product B solution.

[0026] 3. Chop 12 g of trichosanthes root, 5 g of kudzu root, 5 g of codonopsis pilosula, and 3 g of scrophularia root, then put them into 5 times the amount of water, heat and boil for water extraction twice, with the boiling time each time being more than 4 hours. Concentrate the water extraction solution by heating, filter it to obtain water extraction solution C;

[0027] 4. Combine A, B and C. Add 3 times the amount of 70 - 95% ethanol, mix well, and let it stand at 4°C - 8°C for 16 - 24 hours. Filter to remove the precipitate. Obtain solution C, recover the ethanol from solution C, and concentrate the recovered medicinal liquid by heating to obtain solution D.

[0028] 5. Take solution D, add appropriate amount of syrup and excipients, can it, sterilize it, and package it to obtain the finished product, and the product name is "Shutangbao Oral Liquid".

[0029] Embodiment 2:

[0030] Weigh the following traditional Chinese medicine components: (unit: g)

[0031] Acid litchi 6 g, pomelo 6 g, guava 5 g, mulberry 4.5 g, wolfberry 5 g, trichosanthes root 13, kudzu root 6, codonopsis pilosula 6, scrophularia root 4.

[0032] Its production steps are as follows:

[0033] 1. Take the above various components, and in the production process, perform steps such as squeezing the juice, water extraction, and alcohol precipitation to obtain concentrated solution D.

[0034] 2. Concentrate Liquid D by heating to obtain the fluid extract E, and then perform spray drying to obtain the intermediate dry extract powder F.

[0035] 3. Take the dry extract powder F, mix it with excipients, granulate, fill into capsules and subpackage, and then package with aluminum foil to obtain the finished product. The product name is "Shutangbao Capsules".

[0036] Example 3:

[0037] Weigh the following traditional Chinese medicine ingredients: (unit: g)

[0038] Litchi chinensis Sonn. var. philippinensis Radl. 5.5 g, Citrus maxima (Burm.) Merr. 6.5 g, Psidium guajava Linn. 5.5 g, Morus alba L. 4 g, Lycium barbarum L. 4.5 g, Trichosanthes kirilowii Maxim. 14, Pueraria lobata (Willd.) Ohwi 7, Codonopsis pilosula (Franch.) Nannf. 7, Scrophularia ningpoensis Hemsl. 5.

[0039] Its production steps are as follows:

[0040] 1. Take the above various drugs. During the production process, perform steps such as juicing, water extraction, and alcohol precipitation in the same way as the capsule preparation method to obtain the dry extract powder F.

[0041] 2. Take the dry extract powder F, mix it with excipients, granulate, dry, subpackage into bags to obtain the finished product. The product name is "Shutangbao Granules".

[0042] Example 4:

[0043] Take the following traditional Chinese medicine ingredients (unit: g)

[0044] Litchi chinensis Sonn. var. philippinensis Radl. 8, Citrus maxima (Burm.) Merr. 12, Psidium guajava Linn. 8, Morus alba L. 7, Lycium barbarum L. 9, Trichosanthes kirilowii Maxim. 15, Pueraria lobata (Willd.) Ohwi 8, Codonopsis pilosula (Franch.) Nannf. 8, Scrophularia ningpoensis Hemsl. 7.

[0045] Its production steps are as follows:

[0046] 1. Take the above various drugs. During the production process, perform steps such as juicing, water extraction, and alcohol precipitation in the same way as the capsule preparation to obtain the intermediate fluid extract E.

[0047] 2. Take the intermediate product fluid extract E, mix it with appropriate excipients, granulate, tableting, package to obtain the finished product. The product name is "Shutangbao Tablets".

[0048] Example 5:

[0049] Take the following traditional Chinese medicine ingredients (unit: g)

[0050] Litchi chinensis Sonn. var. philippinensis Radl. 10, Citrus maxima (Burm.) Merr. 15, Psidium guajava Linn. 10, Morus alba L. 8, Lycium barbarum L. 10, Trichosanthes kirilowii Maxim. 15, Pueraria lobata (Willd.) Ohwi 10, Codonopsis pilosula (Franch.) Nannf. 10, Scrophularia ningpoensis Hemsl. 8.

[0051] Its production steps are as follows:

[0052] Take the above various drugs. During the production process, perform steps such as juicing, water extraction, and alcohol precipitation in the same way as the capsule preparation to obtain the intermediate fluid extract E.

[0053] Take the intermediate product, the fluid extract E, mix it with appropriate excipients, make it into long-acting capsules, package it to obtain the finished product, and the product name is "Sutangbao Long-acting Capsules".

[0054] The following is the clinical research report of the present invention:

[0055] The drug of the present invention was entrusted to four provincial-level hospitals for clinical verification. The working steps and experimental results are as follows: Clinical data:

[0056] I. General information

[0057] There were 156 cases of type 2 diabetes, all of which met the diagnostic criteria for type 2 diabetes. Most of them were newly admitted inpatients and a small number were outpatients. According to the WHO diagnostic criteria for diabetes, 156 cases were diagnosed as non-insulin-dependent diabetes mellitus (NIDDM) and 2 cases were insulin-dependent diabetes mellitus (IDDM). Among them, 89 were male and 69 were female. The 2 IDDM patients were 1 male and 1 female, and their ages were 18 years old and 22 years old respectively. The ages of the remaining 156 NIDDM patients were as follows: 15 cases were under 39 years old, 29 cases were ~49 years old, 33 cases were ~59 years old, 59 cases were ~69 years old, and 20 cases were ~83 years old. The youngest age was 30 years old and the oldest was 83 years old. After admission and before taking the medicine, the fasting and 2-hour postprandial blood glucose and triglyceride levels were measured. Then, it was taken 3 times a day, 10 ml each time, before meals, and after 2 weeks of continuous use, the fasting and 2-hour postprandial blood glucose and triglyceride levels were rechecked. Blood glucose detection method: Glucose oxidase method; Triglyceride detection method: GPO-POD enzyme method. The Shutangbao oral liquid was developed by this research group and produced by Guangxi Rongxian Xinghuo Beverage and Food Factory.

[0058] II. Diagnostic criteria:

[0059] According to the WHO diagnostic criteria for diabetes, non-insulin-dependent and insulin-dependent diabetes were diagnosed.

[0060] 1. Toxic and side effects: No adverse reactions and toxic and side effects occurred during the clinical trial.

[0061] 2. Typical cases:

[0062] Case 1: Li Mou, male, 72 years old, a retired cadre of an organ in Guangxi. An inpatient in the Department of Diabetes, Jiangbin Hospital of the Autonomous Region. Admitted to the hospital in November 1995. Clinically diagnosed with type 2 diabetes. Before taking other hypoglycemic drugs, Shutangbao was tested for 3 days, 3 times a day, 10 ml each time, before meals. The experimental results showed that the blood glucose levels before taking the medicine, 1 hour, 4 hours, and 4 days after taking the medicine were 253, 128, 82, and 76 mg / dL respectively. The self-perceived symptoms improved, the urine volume and water intake decreased, and the curative effect was remarkable.

[0063] Case 2:

[0064] Wang, male, 75 years old, from Nanning, cadre. Admitted to Jiangbin Hospital of the autonomous region in August 1995. Clinically diagnosed with type 2 diabetes. Took Shutangbao for 3 days, 3 times a day, 10 ml each time, taken before meals. Experimental results: blood glucose levels before taking, 1 hour after taking, 4 hours after taking, and 4 days after taking were 321, 243, 72, and 122 mg / dL respectively. Self-reported symptoms improved, urine volume and water intake decreased, and the curative effect was remarkable.

[0065] Case 3:

[0066] Xu, female, 56 years old, from Nanning, cadre. Patient of the People's Hospital of the autonomous region. Clinically diagnosed with type 2 diabetes. In September 1995, under the guidance of a chief physician, tried taking Shutangbao for 15 days. Fasting blood glucose and 2-hour postprandial blood glucose before taking were 19.6 and 22.7 mmol / L respectively. After taking Shutangbao, fasting blood glucose and 2-hour postprandial blood glucose were 11.2 and 13.1 mmol / L respectively. Self-reported symptoms improved, urine volume and water intake decreased, and the curative effect was remarkable.

[0067] Case 4:

[0068] Zhu, male, 44 years old, inpatient of the Affiliated Hospital of Youjiang Medical University. Admitted to the Department of Diabetes in November 1995. Clinically diagnosed with type 2 diabetes. Took Shutangbao for 15 days. 3 times a day, 10 ml each time, taken before meals. Fasting blood glucose and 2-hour postprandial blood glucose before taking were 8.0 and 17.27 mmol / L respectively. After taking, fasting blood glucose and 2-hour postprandial blood glucose were 6.0 and 11.30 mmol / L respectively. Self-reported symptoms improved, urine volume and water intake decreased, and the curative effect was remarkable.

[0069] Case 5:

[0070] Huang, male, 70 years old, inpatient of the Affiliated Hospital of Youjiang Medical University. Clinically diagnosed with type 2 diabetes. Took Shutangbao for 15 days. 3 times a day, 10 ml each time. Before taking the medicine, serum total cholesterol (T-ch), cholesterol in high-density lipoprotein (HDL-C), and triglyceride (TG) were 6.41, 0.56, and 7.52 mmol / L respectively. After taking, they were 5.18, 1.16, and 4.52 mmol / L respectively. Self-reported symptoms improved, and the curative effect was remarkable.

[0071] Summary:

[0072] The above clinical data reveal:

[0073] 1. The drug Shutangbao of the present invention has the effects of clearing heat and promoting fluid production, nourishing yin and tonifying the kidney, and is applicable to the treatment of consumptive thirst (diabetes).

[0074] 2. The Shutangbao of the present invention has the effects of reducing blood glucose and blood lipids on type 2 diabetes, and the curative effect is obvious. It is applicable to the treatment of type 2 diabetes.

[0075] 3. This product is safe and reliable, and no obvious adverse reactions or toxic and side effects were found during the observation of patients.

[0076] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A novel Chinese medicine composition for lowering blood sugar that can be used as both medicine and food, characterized in that: The invention is prepared from the following raw materials in parts by weight: 5-15 parts of grapefruit, 5-10 parts of litchi, 5-10 parts of guava, 3-8 parts of mulberry, 3-10 parts of wolfberry, 12-15 parts of trichosanthes, 5-10 parts of kudzu root, 5-10 parts of codonopsis pilosula and 3-8 parts of radix polygoni aviculare.

2. A novel Chinese medicine composition for lowering blood sugar for both medical and edible use according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 10 parts of pomelo, 8 parts of litchi, 8 parts of guava, 5 parts of mulberry, 8 parts of wolfberry, 13 parts of trichosanthes, 8 parts of kudzu root, 8 parts of codonopsis pilosula and 5 parts of radix polygoni aviculare.

3. A novel Chinese medicine composition for lowering blood sugar for both medical and edible use according to claim 1, characterized in that: The litchi is sour litchi.

4. A novel edible and medicinal hypoglycemic Chinese medicine composition and its preparation method according to claim 1, characterized in that: (1) Sour lychee and pomelo pulp are squeezed with a juicer, the juice is filtered, and heated and concentrated to obtain liquid A; (2) Add 5 times the amount of water to mulberry, wolfberry and guava, heat and boil, extract twice, each time for 2-3 hours, heat and concentrate the water extract, filter, and obtain water extract B; (3) Chop Radix Trichosanthis, Radix Puerariae, Codonopsis pilosula and Radix Glehniae, add 5 times the amount of water, heat and boil the water extract twice, each time boiling for more than 4 hours, heat and concentrate the water extract, filter, and obtain water extract C; (4) Mixing Solution A, Solution B and Solution C, adding 70-95% ethanol to the mixture for precipitation, the volume ratio of which is 1:

3. After mixing, the mixture is placed at 4°C-8°C for 16-24 hours, and the precipitate is filtered to obtain Solution C; (5) Recovering ethanol: placing liquid C in an ethanol recovery device to recover ethanol, heating and concentrating the recovered liquid to obtain liquid D, taking liquid D, adding appropriate amounts of syrup and excipients to obtain an oral solution, or continuing to heat and concentrate liquid D to obtain a fluid extract E, spray drying to obtain a dry extract powder, taking dry extract powder F, mixing it with appropriate amounts of excipients to prepare granules, or adding appropriate amounts of excipients to prepare capsules, tablets, long-acting capsules and other pharmaceutically usable dosage forms.