Antibacterial super-lubricity catheter

Abstract

The invention discloses an antibacterial super-lubricity catheter, and belongs to the field of new materials. The urethral catheter is prepared by the following steps: soaking the urethral catheter in a 3-aminopropyltrimethoxysilane solution, taking out the urethral catheter and drying the urethral catheter; immersing the dried catheter into a phytic acid solution, taking out and drying; and finally, immersing the dried catheter in a long-acting antibacterial material JUC and PEG mixed solution, slowly pulling out the catheter, and drying a sample in a drying oven to obtain a target product.

Description

Technical Field

[0001] The present invention relates to the field of materials, and particularly to an antibacterial super-slippery coated catheter. Background Art

[0002] Among all hospital-acquired infections, urinary tract infections account for about 40%, and 80% of urinary tract infections are caused by catheters. Catheter-induced urinary tract infections account for 35% - 50% of hospital infections in developed countries, ranking first among hospital infections. In addition, clinically, catheters need to be in contact with body tissues for a long or short time. Each time the catheter is inserted or removed from the tissue, the patient will experience varying degrees of burning pain, which is likely to cause corresponding mucosal damage and even tissue inflammation. This is mainly due to the relatively large friction coefficient between the surface material of the catheter and body tissues. Therefore, it is an important issue that urgently needs to be solved to prepare a catheter with anti-infection and lubrication functions. Summary of the Invention

[0003] The present invention provides a method for preparing an antibacterial super-slippery catheter that is simple, convenient, fast, easy to operate, and has less introduction of raw materials, effectively solving the problem of complex preparation, and can effectively antibacterial and reduce pain.

[0004] The object of the present invention can be achieved by the following technical solutions:

[0005] A method for preparing an antibacterial super-slippery coated catheter, the method comprising the following steps:

[0006] (1) 3-aminopropyltrimethoxysilane is added to a mixed solution of methanol and water, and stirred at room temperature for 0.5 - 3 hours to obtain a 3-aminopropyltrimethoxysilane solution; then the catheter is immersed in the 3-aminopropyltrimethoxysilane solution for 10 - 30 min, taken out and dried;

[0007] (2) The catheter dried in step (1) is immersed in the phytic acid solution described in step (3) for 10 - 60 min, taken out and dried;

[0008] (3) The catheter dried in step (2) is immersed in a mixed solution of a long-acting antibacterial material JUC and PEG for 10 - 60 min, slowly pulled out, and the sample is placed in a drying oven for drying to obtain the target product.

[0009] In the technical solution of the present invention: in step (1), the volume ratio of 3-aminopropyltrimethoxysilane, methanol and water is 0.1 - 5:80 - 190:10 - 50.

[0010] In the technical solution of the present invention: the catheter used in step (1) is a silicone catheter or a latex catheter.

[0011] In the technical solution of the present invention: in step (2), the concentration of the phytic acid solution is 0.1-2 wt%.

[0012] In the technical solution of the present invention: in the mixed solution of the long-acting antibacterial material JUC and PEG in step (3), the concentration of JUC is 0.1-5 wt%, and the concentration of PEG is 0.1-5 wt%.

[0013] In the technical solution of the present invention: in the mixed solution of the long-acting antibacterial material JUC and PEG in step (3), the concentration of JUC is 0.1-3.0 wt%, and the concentration of PEG is 0.1-3.0 wt%.

[0014] Advantages of the present invention:

[0015] The long-acting antibacterial material-coated catheter according to the technical solution of the present invention has a bactericidal effect on Staphylococcus aureus and Escherichia coli, and the bactericidal rate reaches more than 90%, with relatively low cytotoxicity and good lubricity. Specific embodiments

[0016] The following further illustrates the present invention in conjunction with embodiments, but the protection scope of the present invention is not limited thereto: Embodiment 1. Antibacterial and super-slippery coated latex catheter

[0017] 1. Prepare a silane coupling agent solution: 3-aminopropyltrimethoxysilane solution: 2 mL of 3-aminopropyltrimethoxysilane is added dropwise to a mixed solution of 180 mL of methanol and 20 mL of ultrapure water, and the solution is stirred at room temperature for 60 minutes.

[0018] 2. Immerse the catheter in the silane coupling agent solution: The silicone catheter is immersed in a 1 wt% 3-aminopropyltrimethoxysilane solution for 20 min, and then taken out and dried in an oven at 40°C.

[0019] 3. Prepare a phytic acid solution: Prepare a 0.5 wt% aqueous phytic acid solution.

[0020] 4. Immerse the catheter in the phytic acid solution: The catheter is immersed in a 0.5 wt% phytic acid solution for 15 min, and then taken out and dried in an oven at 40°C.

[0021] 5. Preparation of the super-slippery and antibacterial catheter: The treated catheter is immersed in a mixed solution of 0.2 wt% JUC and 1 wt% PEG (the solvent is water) for 10 min, slowly pulled out, and the sample is placed in an oven at 40°C for drying.

[0022] Embodiment 2. Antibacterial and super-slippery coated silicone catheter

[0023] 1. Prepare a silane coupling agent solution: 3-aminopropyltrimethoxysilane solution: 0.5 mL of 3-aminopropyltrimethoxysilane is added dropwise to a mixed solution of 180 mL of absolute ethanol and 20 mL of ultrapure water, and the solution is stirred at room temperature for 120 minutes.

[0024] 2. Soaking the catheter in silane coupling agent solution: The catheter was soaked in a 0.25 wt% 3-aminopropyltrimethoxysilane solution for 15 min, and then taken out and dried in an oven at 40 °C.

[0025] 3. Preparing phytic acid solution: Prepare an aqueous phytic acid solution with a concentration of 0.25 wt%.

[0026] 4. Soaking the catheter in phytic acid solution: The latex catheter was soaked in a 0.25 wt% phytic acid solution for 30 min, and then taken out and dried in an oven at 40 °C.

[0027] 5. Preparation of super-slippery antibacterial catheter: The treated catheter was immersed in a mixture of 0.1 wt% JUC and 1 wt% PEG (with water as the solvent) for 30 min, slowly pulled out, and the sample was placed in an oven at 40 °C for drying.

[0028] Performance detection:

[0029] Referring to standards such as "YY 0326-2016 Disposable Sterile Catheters", various indicators of Example 1 and Example 2 were detected, and the results are as follows:

[0030] Table 1. Detection results of samples in Example 1 and Example 2

[0031]

[0032] Conclusion: As can be seen from Table 1, the samples in Example 1 and Example 2 passed all the detections and met the requirements.

[0033] Table 2. Bactericidal effect, cytotoxicity, and surface sliding performance tests of samples in Example 1 and Example 2.

[0034]

[0035] Example 1 and Example 2 met the requirements for bactericidal effect against Staphylococcus aureus and Escherichia coli, and the bactericidal rates against Staphylococcus aureus and Escherichia coli were both 100%, reaching over 90%; the cytotoxicity was small and the lubricity was good.

Claims

1. A method for preparing an antibacterial super-slip coating urinary catheter, characterized in that: The method comprises the following steps: (1) adding 3-aminopropyltrimethoxysilane to a mixture of methanol and water, stirring at room temperature for 0.5 to 3 hours to obtain a 3-aminopropyltrimethoxysilane solution; then immersing a urinary catheter in the 3-aminopropyltrimethoxysilane solution for 10 to 30 minutes, taking it out and drying it; (2) soaking the catheter dried in step (1) in the phytic acid solution described in step (3) for 10 to 60 minutes, taking it out and drying it; (3) The catheter dried in step (2) is immersed in a mixture of long-acting antibacterial materials JUC and PEG for 10 to 60 minutes, slowly pulled out, and the sample is placed in a drying oven to dry, thereby obtaining the target product.

2. The preparation method according to claim 1, characterized in that: In step (1), the volume ratio of 3-aminopropyltrimethoxysilane, methanol and water is 0.1-5:80-190:10-50.

3. The preparation method according to claim 1, characterized in that: The urinary catheter used in step (1) is a silicone urinary catheter or a latex urinary catheter.

4. The preparation method according to claim 1, characterized in that: The concentration of the phytic acid solution in step (2) is 0.1-2 wt%.

5. The preparation method according to claim 1, characterized in that: In step (3), the long-acting antibacterial material JUC and PEG mixed solution has a JUC concentration of 0.1 to 5 wt %, and a PEG concentration of 0.1 to 5 wt %.

6. The preparation method according to claim 1, characterized in that: In step (3), the long-acting antibacterial material JUC and PEG mixed solution has a JUC concentration of 0.1 to 3.0 wt % and a PEG concentration of 0.1 to 3.0 wt %.

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