Control method and control equipment for tumor electric field treatment system, tumor electric field treatment system, computer readable storage medium and computer program product

Abstract

The invention provides a control method and control equipment for a tumor electric field treatment system, the tumor electric field treatment system, a computer readable storage medium and a computer program product. The method comprises the following steps: determining a first voltage value between an initial voltage and a target voltage of an alternating electric field voltage of the tumor electric field treatment system; controlling the alternating electric field voltage of the tumor electric field treatment system to be boosted at a first speed between the initial voltage and the first voltage value; controlling the alternating electric field voltage of the tumor electric field treatment system to be boosted at a second speed lower than the first speed between the first voltage value and the target voltage; dividing a space between the first voltage value and the target voltage into a plurality of boosting intervals by using a plurality of voltage critical values; and in each boosting interval in the plurality of boosting intervals, controlling the alternating electric field voltage of the tumor electric field treatment system to be maintained for a preset time period every time the alternating electric field voltage is boosted by a preset voltage value at the second speed.

Description

Technical Field

[0001] The present disclosure relates to the technical field of medical devices, and particularly to a control method, a control device, a tumor electrotherapy system, a computer-readable storage medium, and a computer program product for a tumor electrotherapy system. Background Art

[0002] Electrotherapy is a tumor treatment method that interferes with the mitotic process of tumor cells through low-intensity, medium-high frequency alternating electric signals. Research shows that electrotherapy has significant effects in the treatment of diseases such as glioblastoma, non-small cell lung cancer, and malignant pleural mesothelioma. The electric field applied in this treatment method can affect the aggregation of tubulin, prevent the formation of the spindle, inhibit the mitotic process, and induce apoptosis of cancer cells.

[0003] Currently, a tumor electrotherapy system alternately applies alternating current signals to at least two pairs of electrodes that are in direct contact with the patient's skin in sequence to apply an alternating electric field voltage to the tumor site in at least two directions in a cyclic and alternating manner for tumor electrotherapy.

[0004] However, in the above system, voltage mutations occur when switching between alternating electric field voltages in different directions, which causes stinging pain to the patient's skin and affects the patient's health. In addition, the current tumor electrotherapy system lacks temperature control that cooperates with the control of the electric field voltage, and it is easy for the electrode temperature to be too high, causing low-temperature burns, or the temperature is insufficient and the alternating current signal cannot be applied in time. Summary of the Invention

[0005] In view of at least one of the above problems, the present disclosure provides a control solution for a tumor electrotherapy system, which eliminates the skin stinging caused by voltage mutations generated when switching between alternating electric field voltages in different directions by raising the alternating electric field voltage of the tumor electrotherapy system to the target treatment voltage in stages at different voltage boost speeds.

[0006] According to one aspect of the present disclosure, a control method for a tumor electrotherapy system is provided. The control method includes: determining a first voltage value between the initial voltage and the target voltage of the alternating electric field voltage of the tumor electrotherapy system; controlling the alternating electric field voltage of the tumor electrotherapy system to boost at a first speed between the initial voltage and the first voltage value; controlling the alternating electric field voltage of the tumor electrotherapy system to boost at a second speed lower than the first speed between the first voltage value and the target voltage; dividing the interval between the first voltage value and the target voltage into multiple voltage boost intervals by using multiple voltage critical values; and in each of the multiple voltage boost intervals, controlling the alternating electric field voltage of the tumor electrotherapy system to maintain a predetermined time period for every predetermined voltage value increase at the second speed.

[0007] In some embodiments, the plurality of voltage critical values are equally spaced between the first voltage value and the target voltage.

[0008] In some embodiments, the plurality of voltage critical values are not equally spaced between the first voltage value and the target voltage.

[0009] In some embodiments, for every two adjacent voltage critical values among the plurality of voltage critical values, the predetermined time period is equal.

[0010] In some embodiments, for every two adjacent voltage critical values among the plurality of voltage critical values, the predetermined time period is not equal and gradually increases as the voltage critical value increases.

[0011] In some embodiments, in each boosting interval among the plurality of boosting intervals, controlling the alternating electric field voltage of the tumor electric field treatment system to increase by a predetermined voltage value at the second speed and maintaining the predetermined time period further includes: between the first voltage value and the target voltage, controlling the alternating electric field voltages in two directions of the tumor electric field treatment system to boost at the second speed in sequence.

[0012] In some embodiments, in each boosting interval among the plurality of boosting intervals, controlling the alternating electric field voltage of the tumor electric field treatment system to increase by a predetermined voltage value at the second speed and maintaining the predetermined time period further includes: after passing through each boosting interval, after controlling the alternating electric field voltage in any one direction of the tumor electric field treatment system to increase by the predetermined voltage value at the second speed and maintaining the predetermined time period, until boosting to the target voltage and maintaining.

[0013] In some embodiments, the control method further includes: acquiring the electrode temperature of the tumor electric field treatment system; determining whether the electrode temperature is higher than a first temperature threshold; and in response to determining that the electrode temperature is higher than the first temperature threshold, controlling the alternating electric field voltage of the tumor electric field treatment system to decrease at a third speed based on the current voltage value.

[0014] In some embodiments, the control method further includes: determining whether the electrode temperature is higher than a second temperature threshold, where the second temperature threshold is greater than the first temperature threshold; and in response to determining that the electrode temperature is higher than the second temperature threshold, controlling the alternating electric field voltage of the tumor electric field treatment system to return to the initial voltage.

[0015] According to another aspect of the present disclosure, there is provided a control device for a tumor electric field therapy system, including: at least one processor; and at least one memory, the at least one memory being coupled to the at least one processor and storing instructions for execution by the at least one processor, the instructions when executed by the at least one processor causing the computing device to perform the steps of the method as described above.

[0016] According to yet another aspect of the present disclosure, there is provided a tumor electric field therapy system, including: the control device as described above; an electric field generating device electrically connected to the control device; and at least two pairs of electrodes electrically connected to the electric field generating device, wherein the control device controls the electric field generating device to alternately apply the alternating electric field voltage to the at least two pairs of electrodes.

[0017] In some embodiments, the tumor electric field therapy system further includes: a temperature sensor configured to detect the electrode temperature of at least one of the at least two pairs of electrodes.

[0018] According to still another aspect of the present disclosure, there is provided a computer-readable storage medium having computer program code stored thereon, the computer program code when run performing the control method as described above.

[0019] According to still another aspect of the present disclosure, there is provided a computer program product including a computer program, the computer program when executed by a machine performing the control method as described above. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] By referring to the following description of the specific embodiments of the present disclosure given in the accompanying drawings, the present disclosure will be better understood, and other objects, details, features and advantages of the present disclosure will become more apparent.

[0021] Figure 1 FIG. shows a schematic block diagram for implementing a tumor electric field therapy system according to an embodiment of the present disclosure.

[0022] Figure 2 FIG. shows an exemplary flowchart of a control method for a tumor electric field therapy system according to an embodiment of the present disclosure.

[0023] Figure 3 FIG. shows an exemplary flowchart of a process for boosting the alternating electric field voltage of a tumor electric field therapy system 100 at a second speed according to some embodiments of the present disclosure.

[0024] Figure 4 FIG. shows an exemplary structural diagram of a control device and an electric field generating device according to some embodiments of the present disclosure.

[0025] Figure 5It is a waveform diagram of a driving signal for periodic direction switching used to control the switching of the electric field application direction applied between the Y-direction electrode and the X-direction electrode.

[0026] Figure 6 It shows a schematic waveform diagram of an alternating electric field generated by applying a driving signal to the electrodes of a tumor electric field treatment system.

[0027] Figure 7 It shows a schematic waveform diagram of an alternating electric field generated by applying multiple different driving signals to the electrodes of a tumor electric field treatment system.

[0028] Figures 8A to 8E They respectively show schematic diagrams of different stages or boosting intervals of the boosting process of the alternating electric field voltage of a tumor electric field treatment system according to an embodiment of the present disclosure.

[0029] Figure 9 It shows a schematic diagram of the continuous voltage trend of the alternating electric field voltage applied in any direction of the electric field in a tumor electric field treatment system according to an embodiment of the present disclosure.

[0030] Figure 10 It shows a method for applying an alternating electric signal based on temperature according to an embodiment of the present disclosure. Detailed implementation mode

[0031] The preferred embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although the preferred embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to make the present disclosure more thorough and complete, and to fully convey the scope of the present disclosure to those skilled in the art.

[0032] In the following description, certain specific details are set forth for the purpose of explaining various embodiments of the invention to provide a thorough understanding of the various embodiments of the invention. However, those skilled in the relevant art will recognize that the embodiments can be practiced without one or more of these specific details. In other cases, well-known devices, structures, and technologies associated with the present disclosure may not be shown or described in detail so as not to unnecessarily obscure the description of the embodiments.

[0033] Unless the context requires otherwise, throughout the specification and claims, the words "comprise" and its variants, such as "comprising" and "having", should be understood in an open, inclusive sense, i.e., should be interpreted as "including, but not limited to".

[0034] References to "one embodiment" or "some embodiments" in the course of the specification mean that the particular features, structures, or characteristics described in connection with the embodiments are included in at least one embodiment. Thus, the appearances of "in one embodiment" or "in some embodiments" in various places throughout the specification are not necessarily all referring to the same embodiment. Additionally, the particular features, structures, or characteristics may be combined in any manner in one or more embodiments.

[0035] Furthermore, the terms first, second, third, fourth, etc. used in the specification and claims are for the sole purpose of clearly distinguishing the respective objects and do not limit the size or other order of the objects they describe.

[0036] Figure 1 A schematic block diagram showing a tumor electric field therapy system 100 for implementing embodiments according to the present disclosure is shown. As Figure 1 shown, the tumor electric field therapy system 100 of the present disclosure is used to apply an alternating electric signal to a patient's tumor site for tumor treatment, and includes a control device 110, an electric field generating device 120 electrically connected to the control device 110, and at least two pairs of electrodes 130 electrically connected to the electric field generating device 120.

[0037] The control device 110 is configured to control the electric field generating device 120 to generate an alternating electric signal for tumor treatment, and cyclically and alternately apply the generated alternating electric signal to at least two pairs of electrodes 130 that are arranged in pairs and affixed to the corresponding body surface of the patient's tumor, thereby alternately generating alternating electric fields in multiple directions that are cyclic and alternating between at least two pairs of electrodes 130 to act on the tumor site and inhibit the proliferation of tumor cells. Herein, the alternating electric signal generated by the electric field generating device 120 and applied to the electrodes 130 is also referred to as an alternating electric field voltage. The control device 110 may include at least one processor 112 and at least one memory 114 coupled to the at least one processor 112, and instructions executable by the at least one processor 112 are stored in the memory 114. When the instructions are executed by the at least one processor 112, at least a part of the control method 200 described below is executed.

[0038] The electric field generating device 120 can generate the above-mentioned alternating electric field voltage under the control of the control device 110 and sequentially apply the alternating electric field voltage to the corresponding electrodes 130. An exemplary structure of the electric field generating device 120 can be as follows for reference Figure 4 shown.

[0039] The at least two pairs of electrodes 130 may include two or more pairs of electrodes arranged at equal phase intervals from each other. In Figure 1In an example, at least two pairs of electrodes 130 may include, for example, a pair of Y-direction electrodes 132 and a pair of X-direction electrodes 134. The two electrodes 132 in the pair of Y-direction electrodes 132 and the two electrodes 134 in the pair of X-direction electrodes 134 may be arranged in parallel respectively, and the pair of Y-direction electrodes 132 and the pair of X-direction electrodes 134 may be arranged perpendicular to each other. When the alternating electric field signal generated by the electric field generating device 120 is applied to the pair of Y-direction electrodes 132, an alternating electric field in the Y direction is generated between the two electrodes 132. When the alternating electric field signal generated by the electric field generating device 120 is applied to the pair of X-direction electrodes 134, an alternating electric field in the X direction is generated between the two electrodes 134. The alternating electric field in the X direction and the alternating electric field in the Y direction are perpendicular to each other. The alternating electric field in the X direction and the alternating electric field in the Y direction are periodically alternately applied in a cycle. The application time of the alternating electric field in the X direction is t1, and the application time of the alternating electric field in the Y direction is t2. One application of the alternating electric field in the X direction and the alternating electric field in the Y direction in sequence is recorded as a period T, and T = t1 + t2. Generally, t1 = t2 = 1 second and T = 2 seconds. In other cases, the values of t1 and t2 may be the same or different, and are not limited to 1 second.

[0040] When the electric field generating device 120 alternately applies an alternating electric field voltage to the electrodes 132 and 134, a switching occurs between the alternating electric field in the X direction and the alternating electric field in the Y direction, and a voltage mutation may occur on the electrodes 132 and 134, thereby generating a spike signal impact. On the one hand, this spike signal impact may damage the hardware devices of the control device 110 or the electric field generating device 120, and on the other hand, it may stimulate the skin surface of the patient in contact with the electrodes 132 and 134, causing the patient to feel a tingling sensation. In addition, when the electric field generating device 120 alternately applies an alternating electric field voltage to the electrodes 132 and 134, the electrodes 132 and / or 134 will heat up accordingly. If the applied voltage cannot be adjusted in time according to the electrode temperature, it may occur that the human body surface is scalded due to too high an electrode temperature or the treatment effect cannot be achieved due to too low an electrode temperature.

[0041] To address at least one of the above problems, the present disclosure provides a control solution for a tumor electric field treatment system, which eliminates the skin tingling caused by the voltage mutation generated when switching between alternating electric field voltages in different directions by raising the alternating electric field voltage of the tumor electric field treatment system to the target voltage required for treatment in stages at different boosting speeds.

[0042] In some further embodiments, the present disclosure also timely acquires the electrode temperature and controls the applied alternating electric field voltage according to the electrode temperature, so as to avoid scalding the human body due to too high an electrode temperature or affecting the treatment effect due to too low an electrode temperature.

[0043] Figure 2Shows an exemplary flowchart of a control method 200 for a tumor electric field therapy system 100 according to an embodiment of the present disclosure. The control method 200 can be implemented by Figure 1 the control device 110 shown or implemented in the control device 110.

[0044] As Figure 2 shown, in step 210, the control device 110 can determine a first voltage value between the initial voltage and the target voltage of the alternating electric field voltage of the tumor electric field therapy system 100.

[0045] Here, the initial voltage V 0 refers to the voltage when the tumor electric field therapy system 100 starts treatment, which can usually be 0, or can also be a very small static voltage inside the tumor electric field therapy system 100. In this article, without special explanation, the initial voltage V 0 is defaulted to 0V.

[0046] The target voltage V max refers to the voltage that can act on tumor treatment, that is, the voltage required for tumor treatment. In the following description of this article, the target voltage V max is described as a fixed value, such as 160V. However, those skilled in the art can understand that depending on the different characteristics of different patients or different tumor types, the target voltage V max may be different, and the present disclosure is not limited to a specific target voltage value.

[0047] The first voltage value V a1 is used as the demarcation point between the fast stage and the slow stage of the rise of the alternating electric field voltage, and it can be any value set between the initial voltage V 0 and the target voltage V max In some embodiments, the first voltage value V a1 can be set to any value in the 40%-60% interval between the initial voltage V 0 and the target voltage V max Preferably, the first voltage value V a1 can be set to the intermediate value of the target voltage V max and the initial voltage V 0 Or, the first voltage value V a1 can be set to a voltage value that can achieve a basic tumor treatment effect. For example, assuming that according to clinical experience, an alternating electric field voltage of 80V can play a preliminary inhibitory role for the vast majority of tumors, then the first voltage value V a1 can be set to 80V.

[0048] Next, in step 220, between the initial voltage V 0 and the first voltage value V a1Between them, the control device 110 can control the alternating electric field voltage of the tumor electric field therapy system 100 to increase at the first speed S 1 Boost the voltage.

[0049] Initial voltage V 0 And the first voltage value V a1 The stage between is also referred to as the rapid voltage boost stage in this article. In this stage, the alternating electric field voltage of the tumor electric field therapy system 100 directly increases from the initial voltage V at a relatively fast speed 0 To the first voltage value V a1 . When the first voltage value V a1 Is a voltage value capable of achieving a basic tumor treatment effect, through this rapid voltage boost stage, the tumor electric field therapy system 100 can enter the working state of tumor treatment as soon as possible.

[0050] In some examples, in the rapid voltage boost stage, the alternating electric field voltage in each direction can increase at a speed of, for example, 5V per cycle (i.e., 5V / T) until it reaches the first voltage value V a1 .

[0051] Next, in step 230, between the first voltage value V a1 And the target voltage V max , the control device 110 can control the alternating electric field voltage of the tumor electric field therapy system 100 to increase at a second speed S 1 Lower than the first speed S 2 Boost the voltage.

[0052] Here, the stage between the first voltage value V a1 And the target voltage V max Is also referred to as the slow voltage boost stage in this article. In this stage, the alternating electric field voltage of the tumor electric field therapy system 100 increases at a slower speed until it reaches the target voltage V required for treatment max .

[0053] In some embodiments, the second speed S 2 Can be a fixed value, which makes the alternating electric field voltage in the slow voltage boost stage increase uniformly and slowly.

[0054] In some other embodiments, the second speed S 2 Can be a variable value that gradually decreases as the alternating electric field voltage increases, which can make the increase of the alternating electric field voltage in the slow voltage boost stage more gentle, so that the patient feels more comfortable.

[0055] Furthermore, since the first voltage value V a1 And the target voltage V maxThe voltage value in between is already relatively high. To make it less likely for the patient to feel the voltage change and have a better experience, the slow voltage increase stage can be further divided into multiple voltage increase intervals, and after increasing the voltage in each interval, it is maintained for a period of time to allow the human body to adapt to the increased voltage.

[0056] Figure 3 Shows an exemplary flowchart of the process (step 230) of controlling the alternating electric field voltage of the tumor electric field treatment system 100 at the second speed S 2 for voltage increase.

[0057] As Figure 3 shown, at step 232, the control device 110 can divide the first voltage value V a1 and the target voltage V max into multiple voltage increase intervals by using multiple voltage critical values.

[0058] In some embodiments, multiple voltage critical values (such as V a2 , V a3 , V a4 ...) can be equally spaced between the first voltage value V a1 and the target voltage V max . For example, assuming the target voltage V max is 160V, the first voltage value V a1 is set to 80V, and the number of voltage critical values is 3, then the voltage critical values V a2 , V a3 , V a4 can be set to 100V, 120V, and 140V respectively. In this case, the first voltage value V a1 and the target voltage V max are divided into 4 voltage increase intervals: 80V - 100V, 100V - 120V, 120V - 140V, and 140V - 160V.

[0059] In other embodiments, multiple voltage critical values (such as V a2 , V a3 , V a4 ...) are not equally spaced between the first voltage value V a1 and the target voltage V max . Preferably, in this case, the interval between the voltage critical values can decrease as the voltage critical value increases. For example, assuming the target voltage V max is 160V, the first voltage value V a1 is set to 80V, and the number of voltage critical values is 3, then the voltage critical values V a2 , V a3 , V a4Are set to 105V, 130V, and 145V respectively. In this case, the first voltage value V a1 and the target voltage V max are divided into four boosting intervals: 80V - 105V, 105V - 130V, 130V - 145V, and 145V - 160V.

[0060] In step 234, in each of the multiple boosting intervals, the control device 110 controls the alternating electric field voltage of the tumor treating electric field system 100 at the second speed S 2 to maintain a predetermined time period for each increase of a predetermined voltage value.

[0061] In some embodiments, for every two adjacent voltage critical values among multiple voltage critical values (such as V a2 、V a3 、V a4 ……), the predetermined time periods are equal. In this case, for each increase of a predetermined voltage value of the alternating electric field voltage, an equal time period is maintained.

[0062] In other embodiments, for every two adjacent voltage critical values among multiple voltage critical values (such as V a2 、V a3 、V a4 ……), the predetermined time periods are not equal and gradually increase as the voltage critical values increase. In this case, as the alternating electric field voltage increases, the maintained time period becomes longer and longer, so that the patient feels a more gentle increase in voltage and has a better experience.

[0063] As described above, the tumor treating electric field system 100 includes at least two pairs of electrodes 130. Therefore, in step 234, between the first voltage value V a1 and the target voltage V max , the control device 110 controls at least two pairs of electrodes 130 arranged at equal phase intervals of the tumor treating electric field system 100 to boost in sequence along their respective directions at the second speed S 2 . For example, as shown in Figure 1 , when at least two pairs of electrodes 130 include a pair of Y - direction electrodes 132 and a pair of X - direction electrodes 134, the alternating electric field voltages in the X and Y directions of the tumor treating electric field system 100 boost in sequence at the second speed S 2 .

[0064] In the above - mentioned manner, the embodiments of the present disclosure raise the alternating electric field voltage of the tumor treating electric field system 100 to the target voltage V max required for treatment in stages at different boosting speeds, so as to avoid excessive voltage mutations generated when switching the alternating electric field voltages in different directions and eliminate the skin tingling caused by the excessive voltage mutations.

[0065] Further, in some embodiments, the solution of the present disclosure also controls the applied alternating electric field voltage by timely obtaining the electrode temperature and based on the electrode temperature, so as to avoid scalding the human body due to too high electrode temperature or affecting the treatment effect due to too low electrode temperature.

[0066] Specifically, in step 230, the control device 110 may further obtain the electrode temperature of the tumor electric field therapy system 100. Here, the tumor electric field therapy system 100 or any electrode 130 may further include a temperature sensor (not shown in the figure), which can sense the electrode temperature in real time or periodically, and can feedback the sensed electrode temperature to the control device 110.

[0067] The control device 110 pre - sets a first temperature threshold Tth1, a second temperature threshold Tth2 and a third temperature threshold Tth3, where Tth3 < Tth1 < Tth2. It can be determined whether the electrode temperature is higher than the first temperature threshold Tth1, and in response to determining that the electrode temperature is higher than the first temperature threshold Tth1, the control device 110 controls the alternating electric field voltage of the tumor electric field therapy system 100 to step down at a third speed based on the current voltage value. Here, the absolute value of the third speed can be set to be greater than or equal to the second speed. For example, when the second speed is 0.5 V / T, the third speed can be - 1 V / T. In this way, when the electrode temperature exceeds the human body comfort temperature (such as the first temperature threshold Th1), the voltage can be stepped down at a faster speed, so as to quickly reduce the electrode temperature and make the human body return to the comfort temperature.

[0068] In addition, the control device 110 can further determine whether the electrode temperature is higher than the second temperature threshold Tth2, where the second temperature threshold Tth2 is greater than the first temperature threshold Tth1. In response to determining that the electrode temperature is higher than the second temperature threshold Tth2, the control device 110 can control the alternating electric field voltage of the tumor electric field therapy system 100 to return to the initial voltage V 0 , that is, shut down.

[0069] Here, the control device 110 can obtain the electrode temperature after each period T in the fast voltage - boosting stage, and perform voltage reduction or shut - down in the next period T, so as to timely adjust the alternating electric field voltage according to the electrode temperature, improve the temperature feedback speed, and avoid low - temperature scalding or treatment interruption.

[0070] Thereafter, if the control device 110 determines that the detected electrode temperature drops below the third temperature threshold Tth3, the control device 110 can continue the slow voltage - boosting stage described in step 230.

[0071] In this way, the control device 110 can timely learn about the temperature decrease in each cycle T and timely respond to the boosting process, avoiding excessive voltage reduction that may affect the treatment effect.

[0072] Hereinafter, specific embodiments of the present disclosure will be further described in detail through specific examples. Although some examples of the present disclosure are described with specific numerical values and specific settings in the following description, those skilled in the art can understand that these numerical values and settings are only exemplary and do not limit the protection scope of the present disclosure.

[0073] Figure 4 An exemplary structural diagram of the control device 110 and the electric field generating device 120 according to some embodiments of the present disclosure is shown.

[0074] As Figure 4 shown, the electric field generating device 120 may include an inverter boosting control unit 121 electrically connected to the control device 110, a DC power supply control unit 122 communicatively connected to both the control device 110 and the inverter boosting control unit 121, a filter control unit 123 electrically connected to the inverter boosting control unit 121, an AC voltage control unit 124 electrically connected to the filter control unit 123, a direction control unit 125 electrically connected to the control device 110, an X-direction switch 126 electrically connected to the direction control unit 125 and controlling the connection and disconnection between the AC voltage control unit 124 and two X-direction electrodes 134, and a Y-direction switch 127 electrically connected to the direction control unit 125 and controlling the connection and disconnection between the AC voltage control unit 124 and two Y-direction electrodes 132.

[0075] In some examples, the control device 110 can be implemented, for example, by a Microcontroller Unit (MCU). The MCU can have a reference voltage of 3.3V, for example. As described above in combination with Figure 1 the control device 110 may include a processor 112 and a memory 114. In addition, as Figure 4 shown, the control device 110 may further include a Digital-to-Analog Conversion (DAC) module 116 communicatively connected to the processor 112. In addition, in addition to the instructions for executing the Figure 2 control method 200 shown, the memory 114 is further configured to store system parameters of the electric field generating device 120, including the electric field frequency, the amplitude of the output AC voltage, the alternating current signal direction switching period, etc.

[0076] The processor 112 is configured to read the electric field frequency, output AC voltage amplitude, and alternating current signal direction switching period of the electric field generating device 120 from the memory 114. The processor 112 is further configured to output a periodic direction switching drive signal to the direction control unit 125 according to the read alternating current signal direction switching period of the electric field generating device 120. The processor 112 is further configured to output a pulse signal with the same frequency as the electric field frequency of the read electric field generating device 120, and an AC voltage amplitude value equal to the reference voltage amplitude value of the control device 110 to the inverter boost control unit 121 according to the electric field frequency and output AC voltage amplitude of the read electric field generating device 120 and the reference voltage of the control device 110. For example, the processor 112 can output a pulse signal to the inverter boost control unit 121 as a square wave with a frequency of 200 KHz, a voltage amplitude of 3.3 V, and a duty cycle of 50%.

[0077] The digital-to-analog conversion module 116 is communicatively connected to the DC power control unit 122. It has a DAC data register 1160 and can output a corresponding DC voltage to the DC power control unit 122 according to the digital value in the DAC data register 1160 to activate the DC power control unit 122. In one example, for the control device 110 with a reference voltage of 3.3 V, the DAC data register 1160 of the digital-to-analog conversion module 116 can store the digital value 2 12 The processor 112 controls the communication between the digital-to-analog conversion module 116 and the DC power control unit 122 to be turned on and off according to the read alternating current signal direction switching period of the electric field generating device 120, and controls whether the processor 112 outputs a pulse signal to the inverter boost control unit 121.

[0078] In an embodiment where the control device 110 performs boost control according to the electrode temperature, the control device 110 may further include an information feedback unit 118 for receiving the electrode temperature from a temperature sensor attached to the electrode 130.

[0079] In some embodiments, the electric field generating device 120 can output an alternating electric field voltage V with a frequency range of 100 - 500 KHz and a voltage range of 0 V - 160 V according to the treatment needs and specific boost mode and / or buck mode described in detail below tn, to generate a corresponding alternating electric field. Taking the output of a sine wave with a frequency of 200KHz and a peak-to-peak AC voltage of 160V as an example, the DC power supply control unit 122 receives a DC voltage signal of approximately 500mv output from the digital-to-analog conversion module 116 of the control device 110 and outputs a DC voltage signal of approximately 20V to the inverter-booster control unit 121. The inverter-booster control unit 121 has a booster module 1211 and an inverter module 1212 communicating with the booster module 1211. In some embodiments, the booster module 1211 can simultaneously receive a square wave with a frequency of 200KHz, a voltage amplitude of 3.3V, and a duty cycle of 50% output from the processor 112 of the control device 110 and a 20V DC voltage signal output from the DC power supply control unit 122, and perform superposition processing on the received square wave and DC voltage signal and then perform boosting processing to output a square wave with a frequency of 200KHz and an AC voltage amplitude of 80V to the inverter module 1212. The inverter module 1212 receives the square wave signal with a frequency of 200KHz and a voltage amplitude of 80V output from the booster module 1211, and performs inversion processing on the received square wave signal to output a square wave with a frequency of 200KHz and a voltage amplitude of ±80V to the filter control unit 123. The filter control unit 123 performs filtering processing on the received square wave with a frequency of 200KHz and a voltage amplitude of ±80V from the inverter module 1212 to obtain a sine wave with a frequency of 200KHz and an AC voltage peak-to-peak value of 160V, and outputs the sine wave with a frequency of 200KHz and an AC voltage peak-to-peak value of 160V after filtering processing to the AC voltage control unit 124. The AC voltage control unit 124 is simultaneously connected to the X-direction switch 126 and the Y-direction switch 127, and selectively applies the sine wave with a frequency of 200KHz and an AC voltage peak-to-peak value of 160V processed by the filter control unit 123 to two X-direction electrodes 134 or two Y-direction electrodes 132 electrically connected to the AC voltage control unit 124 according to the conduction or disconnection of the X-direction switch 126 and the Y-direction switch 127, so as to generate an X-direction alternating electric field between the two X-direction electrodes 134 or generate a Y-direction alternating electric field between the two Y-direction electrodes 132 to treat the tumor site.

[0080] The direction control unit 125 cyclically controls the on and off states of the X-direction switch 126 and the Y-direction switch 127 according to the periodic direction switching drive signal output by the processor 112 of the control device 110. Specifically, the processor 112 of the control device 110 controls the processor 112 to output a periodic direction switching drive signal to the direction control unit 125 according to the alternating current signal direction switching period read from the electric field generating device 120. Then, through the direction control unit 125, the X-direction switch 126 is alternately and cyclically turned on, the Y-direction switch 127 is turned off, or the X-direction switch 126 is turned off, and the Y-direction switch 127 is turned on, so as to realize that the sinusoidal wave with a frequency of 200 KHz and an alternating electric field voltage V tn received by the AC voltage control unit 124 is cyclically and alternately applied between the two X-direction electrodes 134 and the two Y-direction electrodes 132 electrically connected to the AC voltage control unit 124, so as to cyclically and alternately apply an X-direction alternating electric field and a Y-direction alternating electric field to the tumor site. The alternating electric field voltage V tn indicates the peak-to-peak value of the maximum AC voltage in the nth cycle T, where n ≥ 0 and is an integer.

[0081] That is, when the control device 110 controls the direction control unit 125 to turn on the X-direction switch 126 and turn off the Y-direction switch 127, the AC voltage control unit 124 applies a sinusoidal wave signal with a frequency of 200 KHz and an alternating electric field voltage V tn to the two X-direction electrodes 134 electrically connected thereto, and generates an X-direction alternating electric field between the two X-direction electrodes 134; when the control device 110 controls the direction control unit 125 to turn off the X-direction switch 126 and turn on the Y-direction switch 127, the AC voltage control unit 124 applies a sinusoidal wave signal with a frequency of 200 KHz and an alternating electric field voltage V tn to the two Y-direction electrodes 132 electrically connected thereto, and generates a Y-direction alternating electric field between the two Y-direction electrodes 132. In this embodiment, the duty cycle of the periodic direction switching drive signal output by the processor 112 of the control device 110 to the direction control unit 125 is 50%, and the period T is 2 s. That is, in the first cycle T, the direction control unit 125 controls the X-direction switch 126 to turn on at the 1st s and the Y-direction switch 127 to turn on at the 2nd s. In the second cycle T, the X-direction switch 126 turns on at the 3rd s and the Y-direction switch 127 turns on at the 4th s, and so on in a cycle. The tumor electric field treatment system 100 cyclically and alternately applies an alternating current signal to the X-direction electrode 134 and the Y-direction electrode 132 through the cyclic alternation of the X-direction switch 126 and the Y-direction switch 127 to treat the tumor site. In other embodiments, the duty cycle of the periodic direction switching drive signal output by the processor 112 of the control device 110 to the direction control unit 125 can also be any value between 30% and 50%.

[0082] Figure 5 It is a waveform diagram of a driving signal for periodic direction switching for controlling the switching of the electric field application direction applied between the Y-direction electrode 132 and the X-direction electrode 134, that is, a waveform diagram of the driving signals of the X-direction switch 126 and the Y-direction switch 127 by the direction control unit 125. The driving signal 51 and the driving signal 52 correspond to the X-direction electrode 134 and the Y-direction electrode 132 respectively. The duty ratios of the driving signals 51 and 52 are both 50%, and the period T is also 2 s. The X-direction switch 126 and the Y-direction switch 127 are alternately turned on and off in a cycle. The conduction time and the disconnection time of each switch are both 1 s. And at the same time point, only one of the X-direction switch 126 and the Y-direction switch 127 is on. That is, when the X-direction switch 126 is on, the X-direction electrode 134 generates an X-direction AC electric field. After the X-direction switch 126 is on for 1 s, the X-direction switch 126 is turned off, and the Y-direction switch 127 is turned on. The Y-direction electrode 132 generates a Y-direction AC electric field. After the Y-direction switch 127 is on for 1 s, the Y-direction switch 127 is turned off, and the X-direction switch 126 is turned on again, and so on in a cycle. That is, within one period T, the working time of the X-direction electrode 134 is t1, and the working time of the Y-direction electrode 132 is t2, and T = t1 + t2. The direction control unit 125 makes the target area alternately receive the action of the Y-direction and X-direction AC electric fields by switching the X-direction switch 126 and the Y-direction switch 127. In other embodiments, the duty ratios of the driving signals 51 and 52 can also be any value between 30% and 70%, and the sum of the duty ratios of the driving signals 51 and 52 is not greater than 100%.

[0083] Functionally, the memory 114, the processor 112, and the digital-to-analog conversion module 116 of the control device 110, as well as the inverter boost control unit 121, the filter control unit 123, and the AC voltage control unit 124 of the electric field generating device 120 together constitute an AC signal generator for generating an alternating electric field voltage applied to the electrode 130. The memory 114, the processor 112 of the control device 110, the direction control unit 125 of the electric field generating device 120, and the X-direction switch 126 and the Y-direction switch 127 electrically connected to the direction control unit 125 together constitute an AC signal controller for controlling the alternating electric field voltage applied to the electrode 130. When the AC voltage signal generated by the AC signal generator 10 is applied to the two X-direction electrodes 134, an X-direction alternating electric field is generated between the two X-direction electrodes 134. When the AC voltage signal generated by the AC signal generator 10 is applied to the two Y-direction electrodes 132, a Y-direction alternating electric field is generated between the two Y-direction electrodes 132.

[0084] Before the direction of the alternating electric field in the X direction between the two X-direction electrodes 134 and the alternating electric field in the Y direction between the two Y-direction electrodes 132 needs to be switched, the control device 110 disconnects the communication connection between the digital-to-analog conversion module 116 and the DC power supply control unit 122 through the processor 112, and stops outputting pulse signals to the inverter boost control unit 121 through the processor 112, so as to prevent the alternating electric field in the X direction generated by the two X-direction electrodes 134 and the alternating electric field in the Y direction generated by the two Y-direction electrodes 132 from being conducted simultaneously and affecting the treatment or inhibition effect. After the processor 112 stops outputting pulse signals to the inverter boost control unit 121 and the communication between the digital-to-analog conversion module 116 and the DC power supply control unit 122 is disconnected, then the direction control unit 125 is controlled to switch the X-direction switch 126 and the Y-direction switch 127.

[0085] When the peak-to-peak AC voltage needs to be 160V between both the two X-direction electrodes 134 and the two Y-direction electrodes 132, after the processor 112 of the control device 110 controls the direction control unit 125 to complete the switching of the alternating electric field in the X direction generated between the two X-direction electrodes 134 and the alternating electric field in the Y direction generated between the two Y-direction electrodes 132, the processor 112 of the control device 110 needs to control the digital-to-analog conversion module 116 to output a voltage of 484mV to the DC power supply control unit 122 to start the DC power supply control unit 122, so that the DC power supply control unit 122 outputs a DC electrical signal of 20V to the inverter boost control unit 121. At the same time, the processor 112 outputs a square wave signal of 200KHz to the inverter boost control unit 121, and after being processed by the filter control unit 123, the AC voltage control unit can output a sine wave of 200KHz and a peak-to-peak AC voltage of 160V to the two X-direction electrodes 134 or the two Y-direction electrodes 132. The value in the DAC data register 1160 corresponding to the DC electrical signal of 484mV output by the digital-to-analog conversion module 116 is 600 (484 * 4096 / 3300 ≈ 600). In this way, the control device 110 can control the electric field generating device 120 to generate the required voltage (such as 160V voltage).

[0086] The above combination Figure 4 The generation of the alternating electric field has been described in combination with the specific structural examples of the control device 110 and the electric field generating device 120 shown above. Those skilled in the art can understand that the above description is only exemplary, and the solutions of the present disclosure can also be implemented using control devices 110 and electric field generating devices 120 with other structures. The present disclosure is not limited to the above specific examples.

[0087] In some embodiments, the electric field generating device 120 controls the DC power control unit 122 through the processor 112 of the control device 110 to output a specific DC electric signal in a manner of constant boost time and constant buck time according to the obtained alternating electric signal direction switching period, and further makes the alternating electric field voltage V applied between the two pairs of electrodes 130 tn slowly rise or fall within their respective working periods T, so as to avoid the spike signal impact caused by the sudden change of the AC voltage output by the AC voltage control unit 124 when the control device 110 completes the switching between the X-direction alternating electric field and the Y-direction alternating electric field in the direction control unit 125, damaging the X-direction switch 126 and Y-direction switch 127 of the AC signal controller 20, or the spike pulse generated by the AC voltage mutation is transmitted to the X-direction electrode 134 and Y-direction electrode 132 arranged around the body surface of the tumor site, causing a tingling sensation in the human body. For specific reference, please refer to the following description.

[0088] Figure 6 shows a waveform schematic diagram of the alternating electric field generated by applying a driving signal to the electrode 130 of the tumor electric field treatment system 100; Figure 7 shows a waveform schematic diagram of the alternating electric field generated by applying multiple different driving signals to the electrode 130 of the tumor electric field treatment system 100. As Figure 6 shown, the control device 110 outputs a periodic direction switching driving signal to the direction control unit 125 to generate an X-direction alternating electric field between the two X-direction electrodes 134 for tumor electric field treatment, where the driving signal 51 is a partial waveform diagram of the periodic direction switching driving signal as Figure 5 shown, and the signal 61 is a sine wave schematic diagram applied to the two X-direction electrodes 134. The working time t1 of the X-direction alternating electric field is the electric field continuous conduction time of each period T in this direction. The stage corresponding to the alternating electric signal switching on period t3 (i.e., the boost time in the working period T) is the process in which the AC voltage applied to the two X-direction electrodes 134 rises from 0V to the alternating electric field voltage V tn (the maximum AC voltage value applied to the electrode within this period T), and the stage corresponding to the alternating electric signal switching off period t4 (i.e., the buck time in the working period T) is the process in which the AC voltage applied to the two X-direction electrodes 134 drops from the alternating electric field voltage V tn to the initial voltage V 0 (such as 0V). In this embodiment, the alternating electric signal switching on period t3 and the alternating electric signal switching off period t4 are the same. The time t5 between the boost time t3 and the buck time t4, the alternating electric signal remains at V tnRemain unchanged. To eliminate spike pulses, the control device 110 controls the change amount of the value in the DAC data register 1160 to cause the DC power control unit 122 to output a specific DC electrical signal in a manner of constant boost time and constant buck time, thereby causing the AC voltage output to the AC voltage control unit 124 to slowly increase during the boost process or slowly decrease during the buck process. In this case, the boost speed of the AC voltage within the period T is ΔV = V tn / t3. Similarly, the constant buck time t4 is also used in the buck process to eliminate spike pulses. In this case, the buck speed of the AC voltage within the period T is ΔV = V tn / t4. That is to say, the AC voltage in any electric field application direction within each period T increases to the alternating electric field voltage V tn at a constant boost time t3 or decreases to 0V at a constant buck time t4. The boost speed and the buck speed are equal and are proportional to the voltage value of the alternating electric field voltage V tn . The above-mentioned boost time, hold time, and buck time are all the output processes of the alternating electric field voltage within one period T.

[0089] In an embodiment including temperature control, the control device 110 also controls the alternating electric field voltage applied to the electrode 130 based on the electrode temperature on the electrode 130 obtained in each period T.

[0090] Specifically, a plurality of alternating electric field voltage values can be preset in the memory 114 in the control device 110 of the tumor electric field treatment system 100, such as the initial voltage V 0 , the first voltage value V a1 and a plurality of voltage critical values V a2 , V a3 , V a4 , and the target voltage V max , where V 0 < V a1 <V a2 <V a3 <V a4 <V max . Here, it is assumed that the initial voltage V 0 is 0V and the target voltage V max is 160V. In some embodiments, the value range of the first voltage value V a1 can be 70V - 90V, preferably 80V; the value range of the voltage critical value V a2 can be 90V - 110V, preferably 100V; the value range of the voltage critical value V a3 can be 110V - 130V, preferably 120V; the value range of the voltage critical value V a4The value range of [[ ]] can be 130V - 150V, preferably 140V. Multiple temperature thresholds are also preset in the processor 112 or the memory 114 of the tumor electric field therapy system 100, namely the first temperature threshold Tth1, the second temperature threshold Tth2, and the third temperature threshold Tth3, where Tth3 < Tth1 < Tth2. Further, the value range of Tth3 can be 38°C - 39.6°C, preferably 39.5°C; the value range of Tth1 can be 39.8°C - 40.5°C, preferably 40.4°C; the value range of Tth2 can be 40.8°C - 41.2°C, preferably 41°C.

[0091] Figures 8A to 8E Schematically show different stages or boosting intervals of the boosting process of the alternating electric field voltage of the tumor electric field therapy system 100 according to an embodiment of the present disclosure. Figure 9 Schematically shows the continuous voltage trend of applying an alternating electric field voltage in any direction in the tumor electric field therapy system 100 according to an embodiment of the present disclosure. As Figures 8A to 8E shown, in terms of the output of the alternating electric signal during the overall macroscopic long-term treatment process, when the tumor electric field therapy system 100 starts to output an alternating electric field signal for treatment, the alternating electric field voltage V tn in any direction starts to rise step by step from the initial voltage 0V at the beginning of the first cycle T. When the alternating electric field voltage V tn is at a relatively low voltage, that is, when the alternating electric field voltage V tn is less than V a1 , the heat generated by the electrode 130 is less than the heat dissipated from the application area. Therefore, the temperature of the electrode is lower than the human body temperature of the application area and much less than Tth3, and there will be no over-temperature phenomenon. During this stage, the alternating electric field voltage V tn can be boosted quickly to shorten the boosting time, so that the alternating electric field generated between the corresponding paired electrodes quickly reaches the field strength with a therapeutic effect. The voltage difference between the two alternating electric field voltages V tn in the same electric field application direction within two adjacent cycles T is equal, and is set as V c1 , that is, the corresponding alternating electric field voltage V tn in the latter cycle T minus the corresponding alternating electric field voltage V tn in its previous cycle T has a difference of V c1 , that is, V tn+1 - V tn = V c1 . The value range of this V c1 is 3V - 8V, more preferably 5V. In this case, the boosting speed in the fast boosting stage is the first speed S 1 = V c1 / T.

[0092] When the alternating electric field voltage V tn reaches V a1 , the heat accumulated on the electrode 130 increases, and its temperature gradually rises. At this time, the two alternating electric field voltages V tn in the corresponding electric field application directions within two adjacent periods T have a voltage difference V c2 (i.e., a predetermined voltage value), such that V c2 < V c1 , that is, V tn+1 - V tn = V c2 , and the value range of V c2 is 0.3V - 0.8V, more preferably 0.5V. In this case, the voltage boost rate in the slow voltage boost stage is the second speed S 2 = V c2 / T. And when the alternating electric field voltage V tn increases by this predetermined voltage value each time, it will maintain the current alternating electric field voltage output for a period of time. During this voltage maintenance stage, the voltage difference between the two alternating electric field voltages V tn in two adjacent periods T is 0V, that is, V tn+1 - V tn = 0V, to wait for the target area to adapt to the current electric field intensity and wait for the temperature of the electrode 130 to rise, so as to eliminate the phenomenon of temperature rise lag of the electrode 130 with the maintenance time of the current alternating electric field voltage value, making the subsequent application of the alternating electric signal more accurate. And as the alternating electric field voltage V tn gradually increases, it will successively reach each voltage critical value V a2 , V a3 , V a4 . In this embodiment, the corresponding alternating electric field voltage V tn gradually rises to the aforementioned voltage critical values V a2 , V a3 , V a4 , and the corresponding maintenance time will also increase accordingly until the alternating electric field voltage V tn reaches V max .

[0093] During the voltage boost stage and the maintenance stage of the above-mentioned alternating electric field voltage V tn , the tumor electric field treatment system 100 will detect the temperature of the corresponding electrode 130 once during the time interval when the corresponding pair of electrodes 130 stops applying the alternating electric signal in each period T. When the temperature of the electrode 130 exceeds Tth1, the alternating electric field voltage V tn will enter the voltage drop stage based on the current AC voltage. In the voltage drop stage, the voltage differences between any two alternating electric field voltages V tn in the same electric field application direction within two adjacent periods T are equal, and are set to V c3, that is, the corresponding alternating electric field voltage V within the subsequent period T tn minus the corresponding alternating electric field voltage V within its previous period T tn results in a difference of V c3 , V c3 <V c2 , that is, V tn+1 - V tn =V c3 , and the value range of V c3 is from -3V to -0.8V. Since |V c3 | > |V c2 |, the step-down rate of the corresponding AC voltage is faster than its step-up rate, enabling the step-down amplitude of the alternating electric field voltage V tn in this stage to be greater than the step-up amplitude, thereby reducing the generation of heat in the electrode 130 and achieving rapid cooling. Whenever the alternating electric field voltage V tn drops by a certain voltage value, it will enter the maintenance stage, maintaining the output of the current AC voltage value for a period of time. At this time, the alternating electric field voltage V tn , and further reducing the generated heat, the temperature of the electrode 130 decreases. When maintaining for a period of time, if the temperature of the electrode 130 still exceeds Tth1, the alternating electric field voltage V tn will enter the step-down stage again and repeat the above step-down process. During the step-down stage and the maintenance stage, the tumor electric field treatment system 100 detects the temperature of the corresponding electrode 130 once in each period T. When the temperature of the electrode 130 is lower than Tth3, the corresponding alternating electric field voltage V tn will enter the corresponding step-up stage based on the current AC voltage value.

[0094] During the above step-up stage, step-down stage, and maintenance stage, when the detected temperature of the electrode 130 exceeds Tth2, the tumor electric field treatment system 100 will stop, ceasing the output of the alternating electric signal to prevent the temperature of the corresponding skin patch area from being too high and causing scalding to the patient.

[0095] Specifically, during the step-up stage of the alternating electric field voltage V tn in the overall macroscopic long-term treatment process described above, the alternating electric field voltage V tn in any electric field application direction within each period T starts from 0V, rises to the alternating electric field voltage V tn after a constant step-up time, maintains for a constant constant voltage time, and then drops to 0V after a constant step-down time, completing the output of the alternating electric field voltage V tn within one period T. During the step-down stage of the alternating electric field voltage V tn in the overall macroscopic description above, the alternating electric field voltage V tn in any electric field application direction within each period T tnSimilarly, it starts from 0V and is boosted to the alternating electric field voltage V after a constant boosting time. tn , the alternating electric field voltage V tn After maintaining for a constant voltage time, it is then decreased to 0V after a constant voltage reduction time, completing the output of the alternating electric field voltage V within one cycle T. The AC voltage maintenance stage in the above-mentioned overall macroscopic long-term treatment process is the same and will not be elaborated here. tn In this embodiment, within one cycle T, the boosting time t3 of the alternating electric field in any direction is constantly 50ms, the voltage reduction time t4 is constantly 50ms, and the maintenance time t5 of the alternating electric field voltage V within this cycle T

[0096] is 900ms. The boosting time t3 is equal to the voltage reduction time t4. In other embodiments, the boosting time t3 and the voltage reduction time t4 may not be equal, and the value range is any value within 0ms - 200ms, and the sum of the maintenance time t5, the boosting time t3, and the voltage reduction time t4 of the alternating electric field voltage V within this cycle T tn is not greater than 1000ms. tn

[0097] Figures 5 to 9 Next, specifically referring to Figures 5 to 9 as shown, the output mode of the alternating electric field voltage of the tumor electric field treatment system 100 will be elaborated in detail. The tumor electric field treatment system 100 is turned on, and the X-direction alternating electric field and the Y-direction alternating electric field are periodically cycled and alternately applied. In this embodiment, V a1 = 80V. When V tn < V a1 and the alternating electric field voltage V tn has not reached V max and is in the previous stepwise boosting stage, the voltage difference V tn of the alternating electric field voltage V within two adjacent cycles T c1 = 5V, that is, V tn+1 - V tn = 5V, n ∈ [0, 16], and n is an integer. The specific boosting process is as follows.

[0098] From 0s to 1s, within the 1st cycle T, the X-direction alternating electric field outputs an alternating electric field voltage V t1 of 5V. That is, the alternating electric field voltage V in this direction t1Boost from 0V to 5V and then step down to 0V. Specifically, during the boost process, △V = 5V / 50ms = 0.1V / ms, that is, the electric field voltage in this direction increases by 0.1V every 1ms and lasts for 50ms, raising the voltage from 0V to 5V. The value of the DAC data register 1160 corresponding to the voltage 5V is 20, and the variable △DAC of the DAC data register 1160 per unit time t (1ms) is △DAC = 20 / 50 ≈ 0.4. The control device 110 increases the value of the DAC data register 1160 by 0.4 every 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. Calculating the output corresponding to the value 20 of the DAC data register 1160 is (20 * 3.3 / 4096) * 1000 ≈ 16mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by approximately 0.3mV every 1ms, causing the DC power control unit 122 to boost the voltage by 0.1V every 1ms for 50ms. After uniformly changing 50 times, the alternating electric field voltage V t1 Boost from 0V to 5V and maintain it for 900ms. During the step-down process, t4 is 50ms, △V = -5V / 50ms = -0.1V / ms, that is, the electric field voltage in this direction decreases by 0.1V every 1ms and lasts for 50ms, reducing the voltage from 5V to 0V. The value of the DAC data register 1160 corresponding to the voltage 5V is 20, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 20 / 50 ≈ 0.4. The control device 110 decreases the value of the DAC data register 1160 by 0.4 every 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. Calculating the output corresponding to the value 20 of the DAC data register 1160 is (20 * 3.3 / 4096) * 1000 ≈ 16mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by approximately 0.3mV every 1ms, causing the DC power control unit 122 to step down the voltage by 0.1V every 1ms for 50ms. After uniformly changing 50 times, the voltage decreases from 5V to 0V.

[0099] From 1s to 2s, within the first cycle T, the Y-direction alternating electric field outputs an alternating electric field voltage V t1 of 5V. That is, the alternating electric field voltage V in this direction t1 boosts from 0V to 5V and then steps down to 0V. For the specific output process, refer to the voltage output process of the X-direction alternating electric field from 0s to 1s described above, which will not be elaborated here.

[0100] From 2s to 3s, within the second cycle T, the X-direction alternating electric field outputs an alternating electric field voltage V t2 of 10V. That is, the alternating electric field voltage V in this direction t2Boost from 0V to 10V and then step down to 0V. Specifically, during the boost process, t3 is 50ms, △V = 10V / 50ms = 0.2V / ms, that is, the electric field voltage in this direction boosts by 0.2V every 1ms and lasts for 50ms, raising the voltage from 0V to 10V. The value of the DAC data register 1160 corresponding to the voltage of 10V is 38, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 38 / 50 ≈ 0.8. The control device 110 increases the value of the DAC data register 1160 by 0.8 every 1ms. The output corresponding to the value of the DAC data register 1160 of 4096 is 3.3V. Calculating, the output corresponding to the value of the DAC data register 1160 of 38 is (38 * 3.3 / 4096) * 1000 ≈ 31mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by about 0.6mV every 1ms, causing the DC power control unit 122 to boost by 0.2V every 1ms and last for 50ms. After changing evenly 50 times, the voltage boosts from 0V to 10V and is maintained for 900ms. During the step-down process, t4 is 50ms, △V = -10V / 50ms = -0.2V / ms, that is, the electric field voltage drops by 0.2V every 1ms and lasts for 50ms, dropping the voltage from 10V to 0V. The value of the DAC data register 1160 corresponding to the voltage of 10V is 38, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 38 / 50 ≈ 0.8. The control device 110 decreases the value of the DAC data register 1160 by 0.8 every 1ms. The output corresponding to the value of the DAC data register 1160 of 4096 is 3.3V. Calculating, the output corresponding to the value of the DAC data register 1160 of 38 is (38 * 3.3 / 4096) * 1000 ≈ 31mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by about 0.6mV every 1ms, causing the DC power control unit 122 to step down by 0.2V every 1ms and last for 50ms. After changing evenly 50 times, the voltage steps down from 10V to 0V.

[0101] From 3s to 4s, within the second cycle T, the Y-direction alternating electric field outputs an alternating electric field voltage V t2 of 10V. That is, the alternating electric field voltage Vt2 in this direction boosts from 0V to 10V and then steps down to 0V. For the specific output process, refer to the voltage output process of the X-direction alternating electric field during 2s - 3s mentioned above, which will not be elaborated here.

[0102] From 4s to 5s, within the third cycle T, the X-direction alternating electric field outputs an alternating electric field voltage V t3 of 15V. That is, the alternating electric field voltage V t3 in this direction boosts from 0V to 15V and then steps down to 0V. For the specific output process, refer to the voltage output process of the X-direction alternating electric field during 2s - 3s mentioned above, which will not be elaborated here.

[0103] From 5 s to 6 s, within the 3rd period T, the alternating electric field in the Y direction outputs an alternating electric field voltage V t3 which is 15 V. That is, the alternating electric field voltage V in this direction tn rises from 0 V to 15 V and then drops to 0 V. For the specific output process, refer to the voltage output process of the alternating electric field in the X direction during 2 s - 3 s described above, which will not be elaborated here.

[0104] From 6 s to 7 s, within the 4th period T, the alternating electric field in the X direction outputs an alternating electric field voltage V t4 which is 20 V. That is, the alternating electric field voltage V in this direction tn rises from 0 V to 20 V and then drops to 0 V. Specifically, during the voltage increase, t3 is 50 ms, △V = 20 V / 50 ms = 0.4 V / ms, that is, the electric field voltage in this direction increases by 0.4 V per 1 ms, lasting for 50 ms, and the voltage rises from 0 V to 20 V. The value of the DAC data register 1160 corresponding to the voltage 20 V is 75, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 75 / 50 ≈ 2. The control device 110 increases the value of the DAC data register 1160 by 2 per 1 ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3 V. Calculating the output corresponding to the value 75 of the DAC data register 1160 is (75 * 3.3 / 4096) * 1000 ≈ 60 mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by about 1.2 mV per 1 ms to make the DC power supply control unit 122 boost the voltage by 0.4 V per 1 ms, lasting for 50 ms. After uniformly changing 50 times, the voltage rises from 0 V to 20 V and is maintained for 900 ms. During the voltage decrease, t4 is 50 ms, △V = -20 V / 50 ms = -0.4 V / ms, that is, the electric field voltage drops by 0.4 V per 1 ms, lasting for 50 ms, and the voltage drops from 20 V to 0 V. The value of the DAC data register 1160 corresponding to the voltage 20 V is 75, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 75 / 50 ≈ 2. The control device 110 decreases the value of the DAC data register 1160 by 2 per 1 ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3 V. Calculating the output corresponding to the value 75 of the DAC data register 1160 is (38 * 3.3 / 4096) * 1000 ≈ 60 mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by about 1.2 mV per 1 ms to make the DC power supply control unit 122 drop the voltage by 0.4 V per 1 ms, lasting for 50 ms. After uniformly changing 50 times, the voltage drops from 20 V to 0 V.

[0105] From 7 s to 8 s, within the 4th period T, the alternating electric field in the Y direction outputs an alternating electric field voltage V t4is 20V. That is, the AC electric field voltage V in this direction t4 rises from 0V to 20V and then drops to 0V. For the specific output process, refer to the voltage output process of the X-direction AC electric field from 6s to 7s as described above, and it will not be elaborated here.

[0106] From 8s to 14s, within the 5th cycle T to the 7th cycle T, the X-direction AC electric field and the Y-direction AC electric field alternately output the AC electric field voltage V in sequence according to the above rules tn , that is, the AC electric field voltage V of the AC electric field in the same direction tn increases by 5V every time a cycle T passes.

[0107] From 14s to 15s, within the 8th cycle T, the X-direction AC electric field outputs the AC electric field voltage V t8is 40V. That is, the AC electric field voltage Vt8 in this direction rises from 0V to 40V and then drops to 0V. Specifically, during the voltage rise, t3 is 50ms, △V = 40V / 50ms = 0.8V / ms, that is, the electric field voltage in this direction rises by 0.8V per 1ms and lasts for 50ms, raising the voltage from 0V to 40V. The value of the DAC data register 1160 corresponding to the voltage 40V is 150, and the variable △DAC of the value of the DAC data register 1160 per unit time t is 150 / 50 = 3. The control device 110 increases the value of the DAC data register 1160 by 3 per 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. It is calculated that the output corresponding to the value 150 of the DAC data register 1160 is (150 * 3.3 / 4096) * 1000 ≈ 121mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by about 2.4mV per 1ms to make the DC power control unit 122 boost the voltage by 0.8V per 1ms and last for 50ms. After uniformly changing 50 times, the voltage rises from 0V to 40V and is maintained for 900ms. During the voltage drop, t4 is 50ms, △V = -40V / 50ms = -0.8V / ms, that is, the electric field voltage drops by 0.8V per 1ms and lasts for 50ms, dropping the voltage from 40V to 0V. The value of the DAC data register 1160 corresponding to the voltage 40V is 150, and the variable △DAC of the value of the DAC data register 1160 per unit time t is 150 / 50 ≈ 3. The control device 110 decreases the value of the DAC data register 1160 by 3 per 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. It is calculated that the output corresponding to the value 150 of the DAC data register 1160 is (150 * 3.3 / 4096) * 1000 ≈ 121mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by about 2.4mV per 1ms to make the DC power control unit 122 drop the voltage by 0.8V per 1ms and last for 50ms. After uniformly changing 50 times, the voltage drops from 40V to 0V.

[0108] From 15s to 16s, within the 8th cycle T, the AC electric field in the Y direction outputs an AC electric field voltage V t8 is 40V. That is, the AC electric field voltage V in this direction t8 rises from 0V to 40V and then drops to 0V. For the specific output process, refer to the voltage output process of the AC electric field in the X direction during 14s - 15s described above, which will not be elaborated here.

[0109] From 16s to 22s, within the 9th cycle T to the 11th cycle T, the AC electric fields in the X direction and the Y direction output AC electric field voltages V in sequence according to the above rules tn , that is, the AC electric field voltage V of the AC electric field in the same direction tnIncrease by 5V after one period T.

[0110] From 22s to 23s, within the 12th period T, the alternating electric field in the X direction outputs an alternating electric field voltage V t12 which is 60V. That is, the alternating electric field voltage V in this direction t12 rises from 0V to 60V and then drops to 0V. Specifically, during the voltage increase, t3 is 50ms, △V = 60V / 50ms = 1.2V / ms, that is, the electric field voltage in this direction increases by 1.2V per 1ms and lasts for 50ms, raising the voltage from 0V to 60V. The value of the DAC data register 1160 corresponding to the voltage 60V is 225, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 225 / 50 ≈ 5. The control device 110 increases the value of the DAC data register 1160 by 5 per 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. Calculating the output corresponding to the value 225 of the DAC data register 1160 is (225 * 3.3 / 4096) * 1000 ≈ 181mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by approximately 3.6mV per 1ms, causing the DC power supply control unit 122 to boost the voltage by 1.2V per 1ms for 50ms. After uniformly changing 50 times, the voltage rises from 0V to 60V and is maintained for 900ms. During the voltage decrease, t4 is 50ms, △V = -60V / 50ms = -1.2V / ms, that is, the electric field voltage decreases by 1.2V per 1ms and lasts for 50ms, dropping the voltage from 60V to 0V. The value of the DAC data register 1160 corresponding to the voltage 60V is 225, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 225 / 50 ≈ 5. The control device 110 decreases the value of the DAC data register 1160 by 5 per 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. Calculating the output corresponding to the value 225 of the DAC data register 1160 is (225 * 3.3 / 4096) * 1000 ≈ 181mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by approximately 3.6mV per 1ms, causing the DC power supply control unit 122 to lower the voltage by 1.2V per 1ms for 50ms. After uniformly changing 50 times, the voltage drops from 60V to 0V.

[0111] From 23s to 24s, within the 12th period T, the alternating electric field in the Y direction outputs an alternating electric field voltage V t12 which is 60V. That is, the alternating electric field voltage V in this direction t12 rises from 0V to 60V and then drops to 0V. For the specific output process, refer to the voltage output process of the alternating electric field in the X direction from 22s to 23s above, which will not be elaborated here.

[0112] From 24 s to 30 s, within the 13th cycle T to the 15th cycle T, the AC electric field in the X direction and the AC electric field in the Y direction output the AC electric field voltage V in turn according to the above rules. tn That is, the AC electric field voltage V of the AC electric field in the same direction tn increases by 5 V every time a cycle T passes.

[0113] In this embodiment, V a2 = 100 V. When V a1 ≤V tn <V a2 and the AC electric field voltage V tn has not reached V max and is in the previous stepped boost stage, the voltage difference V tn between the AC electric field voltages V c2 in two adjacent cycles T is 0.5 V. The specific boost process is as described below.

[0114] From 30 s to 31 s, within the 16th cycle T, the AC electric field in the X direction outputs the AC electric field voltage V t16 of 80 V. That is, the AC electric field voltage V in this direction t16Boost from 0V to 80V and then step down to 0V. Specifically, during the boost process, t3 is 50ms, ΔV = 80V / 50ms = 1.6V / ms, that is, the electric field voltage in this direction boosts by 1.6V per 1ms and lasts for 50ms, increasing the voltage from 0V to 80V. The value of the DAC data register 1160 corresponding to the voltage 80V is 300, and the variable ΔDAC of the DAC data register 1160 per unit time t is 300 / 50 = 6. The control device 110 increases the value of the DAC data register 1160 by 6 per 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. Calculating, the output corresponding to the value 300 of the DAC data register 1160 is (300 * 3.3 / 4096) * 1000 ≈ 242mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by approximately 4.8mV per 1ms, enabling the DC power control unit 122 to boost by 1.6V per 1ms and last for 50ms. After uniformly changing 50 times, the voltage increases from 0V to 80V and is maintained for 900ms. During the step-down process, t4 is 50ms, ΔV = -80V / 50ms = -1.6V / ms, that is, the electric field voltage drops by 1.6V per 1ms and lasts for 50ms, reducing the voltage from 80V to 0V. The value of the DAC data register 1160 corresponding to the voltage 80V is 300, and the variable ΔDAC of the DAC data register 1160 per unit time t is 300 / 50 = 6. The control device 110 decreases the value of the DAC data register 1160 by 6 per 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. Calculating, the output corresponding to the value 300 of the DAC data register 1160 is (300 * 3.3 / 4096) * 1000 ≈ 242mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by approximately 4.8mV per 1ms, enabling the DC power control unit 122 to step down by 1.6V per 1ms and last for 50ms. After uniformly changing 50 times, the voltage drops from 80V to 0V.

[0115] From 31s to 32s, within the 16th cycle T, the Y-direction alternating electric field outputs an alternating electric field voltage V t16 is 80V. That is, the alternating electric field voltage V in this direction t16 boosts from 0V to 80V and then steps down to 0V. For the specific output process, refer to the voltage output process of the X-direction alternating electric field during 30s - 31s described above, which will not be elaborated here.

[0116] From 32s to 33s, within the 17th cycle T, the X-direction alternating electric field outputs an alternating electric field voltage V t17 is 80.5V. That is, the alternating electric field voltage V in this direction t17Boost from 0V to 80.5V and then step down to 0V. For the specific output process, refer to the voltage output process of the X-direction alternating electric field from 30s to 31s mentioned above, which will not be elaborated here.

[0117] From 33s to 34s, within the 17th cycle T, the Y-direction alternating electric field outputs an alternating electric field voltage V t17 of 80.5V. That is, the alternating electric field voltage V t17 boosts from 0V to 80.5V and then steps down to 0V. For the specific output process, refer to the voltage output process of the X-direction alternating electric field from 30s to 31s mentioned above, which will not be elaborated here.

[0118] From 34s to 35s, within the 18th cycle T, the X-direction alternating electric field outputs an alternating electric field voltage V t18 of 81V. That is, the alternating electric field voltage V t18 boosts from 0V to 81V and then steps down to 0V. For the specific output process, refer to the voltage output process of the X-direction alternating electric field from 30s to 31s mentioned above, which will not be elaborated here.

[0119] From 35s to 36s, within the 18th cycle T, the Y-direction alternating electric field outputs an alternating electric field voltage V t18 of 81V. That is, the alternating electric field voltage V t18 boosts from 0V to 81V and then steps down to 0V. For the specific output process, refer to the voltage output process of the X-direction alternating electric field from 30s to 31s mentioned above, which will not be elaborated here.

[0120] From 36s to 52s, within the 19th cycle T to the 26th cycle T, the X-direction alternating electric field and the Y-direction alternating electric field alternately output the alternating electric field voltage V tn in accordance with the above rules, that is, the alternating electric field voltage V tn of the same-direction alternating electric field increases by 0.5V every time a cycle T passes.

[0121] When 80V ≤ V tn <100V, the alternating electric field voltage V tn gradually increases step by step as described in the above boosting method until the alternating electric field voltage V tn increases by 5V to reach 85V. In the subsequent 60s (i.e., 30 cycles T), the alternating electric field voltage V tn maintains an output of 85V to wait for the target area to adapt to the current electric field strength and at the same time wait for the temperature of electrode 130 to rise, using the maintenance time of 60s to eliminate the phenomenon of temperature lag of electrode 130.

[0122] That is, from the 16th cycle T to the 26th cycle T, the X-direction alternating electric field and the Y-direction alternating electric field alternately output the alternating electric field voltage V tn, that is, the alternating electric field voltage V of the alternating electric field in the same direction tn increases by 0.5V every time a period T passes. The alternating electric field voltage V of each direction of the alternating electric field tn increases from 80V to 85V through voltage boosting in 10 periods T.

[0123] From the 26th period T to the 56th period T, the alternating electric field voltage V of the X-direction alternating electric field and the Y-direction alternating electric field is alternately output in sequence tn , and during this period, the alternating electric field voltage V of each direction of the alternating electric field tn is kept output at 85V without change.

[0124] From the 56th period T to the 66th period T, the alternating electric field voltage V of the X-direction alternating electric field and the Y-direction alternating electric field is alternately output in sequence according to the above rule tn , that is, the alternating electric field voltage V of the alternating electric field in the same direction tn increases by 0.5V every time a period T passes. The alternating electric field voltage V of each direction of the alternating electric field tn increases from 85V to 90V through voltage boosting in 10 periods T.

[0125] From the 66th period T to the 96th period T, the alternating electric field voltage V of the X-direction alternating electric field and the Y-direction alternating electric field is alternately output in sequence tn , and during this period, the alternating electric field voltage V of each direction of the alternating electric field tn is kept output at 90V without change.

[0126] From the 96th period T to the 106th period T, the alternating electric field voltage V of the X-direction alternating electric field and the Y-direction alternating electric field is alternately output in sequence according to the above rule tn , that is, the alternating electric field voltage V of the alternating electric field in the same direction tn increases by 0.5V every time a period T passes. The alternating electric field voltage V of each direction of the alternating electric field tn increases from 90V to 95V through voltage boosting in 10 periods T.

[0127] From the 106th period T to the 136th period T, the alternating electric field voltage V of the X-direction alternating electric field and the Y-direction alternating electric field is alternately output in sequence tn , and during this period, the alternating electric field voltage V of each direction of the alternating electric field tn is kept output at 95V without change.

[0128] From the 136th period T to the 146th period T, the alternating electric field voltage V of the X-direction alternating electric field and the Y-direction alternating electric field is alternately output in sequence according to the above rule tn , that is, the alternating electric field voltage V of the alternating electric field in the same direction tnIncrease by 0.5V every cycle T. The alternating electric field voltage V of the alternating electric fields in all directions tn Both start from 95V and increase to 100V after 10 cycles T of voltage boost.

[0129] In short, the alternating electric field voltage V tn During the period from 80V to 100V, after it increases by 5V each time, the current voltage output needs to be maintained for 60s.

[0130] In this embodiment, V a3 = 120V. When V a2 ≤V tn <V a3 And when the alternating electric field voltage V tn has not reached V max and is in the previous stepped voltage boost stage, the voltage difference V tn of the alternating electric field voltage V between two adjacent cycles T c2 = 0.5V. The specific voltage boost process is as described below.

[0131] From 71s to 72s, within the 146th cycle T, the X-direction alternating electric field outputs an alternating electric field voltage V t146 of 100V. That is, the alternating electric field voltage V in this direction t146Boost from 0V to 100V and then step down to 0V. Specifically, during the boost, t3 is 50ms, ΔV = 100V / 50ms = 2V / ms, that is, the electric field voltage in this direction boosts by 2V every 1ms and lasts for 50ms, raising the voltage from 0V to 100V. The value of the DAC data register 1160 corresponding to the voltage of 100V is 375, and the variable ΔDAC of the DAC data register 1160 per unit time t is approximately 375 / 50 = 8. The control device 110 increases the value of the DAC data register 1160 by 8 every 1ms. The output corresponding to the value of the DAC data register 1160 of 4096 is 3.3V. Calculating the output corresponding to the value of the DAC data register 1160 of 375 is approximately (375 * 3.3 / 4096) * 1000 ≈ 302mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by approximately 6mV every 1ms, causing the DC power control unit 122 to boost by 2V every 1ms and last for 50ms. After uniform variation 50 times, the voltage is boosted from 0V to 100V and maintained for 900ms. During the step-down, t4 is 50ms, ΔV = -100V / 50ms = -2V / ms, that is, the electric field voltage drops by 2V every 1ms and lasts for 50ms, reducing the voltage from 100V to 0V. The value of the DAC data register 1160 corresponding to the voltage of 100V is 375, and the variable ΔDAC of the DAC data register 1160 per unit time t is approximately 375 / 50 = 8. The control device 110 reduces the value of the DAC data register 1160 by 8 every 1ms. The output corresponding to the value of the DAC data register 1160 of 4096 is 3.3V. Calculating the output corresponding to the value of the DAC data register 1160 of 375 is approximately (375 * 3.3 / 4096) * 1000 ≈ 3012mV. That is to say, the control device 110 reduces the output of the DAC data register 1160 by approximately 6mV every 1ms, causing the DC power control unit 122 to step down by 2V every 1ms and last for 50ms. After uniform variation 50 times, the voltage is stepped down from 100V to 0V.

[0132] From 71s to 72s, within the 146th cycle T, the Y-direction alternating electric field outputs an alternating electric field voltage V t146 of 100V. That is, the alternating electric field voltage V in this direction t146 boosts from 0V to 100V and then steps down to 0V. For the specific output process, refer to the output process of the alternating electric field voltage of 100V in the aforementioned X direction, which will not be elaborated here.

[0133] When 100V ≤ V tn <120V, the alternating electric field voltage V tn is as described in the above boost method. After the alternating electric field voltage V tn reaches 100V, within the subsequent 100s (i.e., 50 cycles T), this alternating electric field voltage V tnThe output is maintained at 100V to wait for the target area to adapt to the current electric field strength, and at the same time wait for the temperature of electrode 130 to rise. The maintenance time of 100s is used to eliminate the temperature lag phenomenon of electrode 130. Then, it gradually increases from 100V until the alternating electric field voltage V within the corresponding period T tn After increasing by 5V to reach 105V, within the subsequent 100s (i.e., 50 periods T), the alternating electric field voltage V tn is maintained at an output of 105V to wait for the target area to adapt to the current electric field strength, and at the same time wait for the temperature of electrode 130 to rise. The maintenance time of 100s is used to eliminate the temperature lag phenomenon of electrode 130. Until the alternating electric field voltage V tn reaches 120V and enters the next stepped voltage boost stage.

[0134] In short, the alternating electric field voltage V tn starting from reaching 100V, that is, stabilizing the output of 100V for 100s, until during the period of 120V, the alternating electric field voltage V tn after increasing by 5V each time, the current voltage output needs to be maintained for 100s.

[0135] In this embodiment, V a4 = 140V. When V a3 ≤ V tn <V a4 and the alternating electric field voltage V tn has not reached V max and is in the previous stepped voltage boost stage, the voltage difference V tn of the alternating electric field voltage V c2 between two adjacent periods T is 0.5V. The specific voltage boost process is as follows.

[0136] From 770s to 771s, within the 386th period T, the X - direction alternating electric field outputs an alternating electric field voltage V t386 of 120V. That is, the alternating electric field voltage V t386Boost from 0V to 120V and then step down to 0V. Specifically, during the boost process, t3 is 50ms, △V = 120V / 50ms = 2.4V / ms, that is, the electric field voltage in this direction boosts by 2.4V per 1ms and lasts for 50ms, raising the voltage from 0V to 120V. The value of the DAC data register 1160 corresponding to the voltage of 120V is 450, and the variable △DAC of the DAC data register 1160 per unit time t is 450 / 50 = 9. The control device 110 increases the value of the DAC data register 1160 by 9 per 1ms. The output corresponding to the value of 4096 in the DAC data register 1160 is 3.3V. It is calculated that the output corresponding to the value of 450 in the DAC data register 1160 is (450 * 3.3 / 4096) * 1000 ≈ 363mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by approximately 7.3mV per 1ms, enabling the DC power control unit 122 to boost by 2.4V per 1ms and last for 50ms. After uniformly changing 50 times, the voltage rises from 0V to 120V and is maintained for 900ms. During the step-down process, t4 is 50ms, △V = -120V / 50ms = -2.4V / ms, that is, the electric field voltage drops by 2.4V per 1ms and lasts for 50ms, reducing the voltage from 120V to 0V. The value of the DAC data register 1160 corresponding to the voltage of 120V is 450, and the variable △DAC of the DAC data register 1160 per unit time t is 450 / 50 = 9. The control device 110 decreases the value of the DAC data register 1160 by 9 per 1ms. The output corresponding to the value of 4096 in the DAC data register 1160 is 3.3V. It is calculated that the output corresponding to the value of 450 in the DAC data register 1160 is (450 * 3.3 / 4096) * 1000 ≈ 363mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by approximately 7.3mV per 1ms, enabling the DC power control unit 122 to step down by 2.4V per 1ms and last for 50ms. After uniformly changing 50 times, the voltage drops from 120V to 0V.

[0137] From 771s to 772s, within the 386th cycle T, the alternating electric field voltage V in the Y direction t386 is 120V. That is, the alternating electric field voltage V in this direction t386 boosts from 0V to 120V and then steps down to 0V. For the specific output process, refer to the output process of the alternating electric field voltage of 120V in the aforementioned X direction, which will not be elaborated here.

[0138] When 120V ≤ V tn <140V, the alternating electric field voltage V tn is as described in the above boost method. After the alternating electric field voltage V tn reaches 120V, within the subsequent 150s (i.e., 75 cycles T), this alternating electric field voltage Vtn Both maintain an output of 120V to wait for the target area to adapt to the current electric field strength, and at the same time wait for the temperature of electrode 130 to rise. Use a maintenance time of 150s to eliminate the phenomenon of temperature lag of electrode 130. Then gradually increase from 120V until the alternating electric field voltage V within the corresponding period T tn After increasing by 5V to reach 125V, within the subsequent 150s (i.e., 75 periods T), the alternating electric field voltage V tn Both maintain an output of 125V to wait for the target area to adapt to the current electric field strength, and at the same time wait for the temperature of electrode 130 to rise. Use a maintenance time of 150s to eliminate the phenomenon of temperature lag of electrode 130. Until the alternating electric field voltage V tn Reaches 140V and enters the next stepped voltage boost stage.

[0139] In short, the alternating electric field voltage V tn Starting from reaching 120V, that is, stabilizing the output of 120V and maintaining it for 150s. Until during the period of 140V, after the alternating electric field voltage Vtn increases by 5V each time, it is necessary to maintain the current voltage output for 150s.

[0140] In this embodiment, V max = 160V. When V a3 ≤V tn ≤V max And when the alternating electric field voltage V tn Has not reached V max And is in the previous stepped voltage boost stage, the voltage difference V tn Of the alternating electric field voltage V between two adjacent periods T c2 = 0.5V. The specific voltage boost process is as described below.

[0141] From 1430s to 1431s, within the 716th period T, the X-direction alternating electric field outputs an alternating electric field voltage V t716 Is 140V. That is, the alternating electric field voltage V in this direction t716Boost from 0V to 140V and then step down to 0V. Specifically, during the boost process, t3 is 50ms, △V = 140V / 50ms = 2.8V / ms, that is, the electric field voltage in this direction boosts by 2.8V per 1ms, lasting for 50ms, and the voltage is boosted from 0V to 140V. The value of the DAC data register 1160 corresponding to the voltage of 140V is 525, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 525 / 50 ≈ 11. The control device 110 increases the value of the DAC data register 1160 by 11 per 1ms. The output corresponding to the value of the DAC data register 1160 of 4096 is 3.3V. Calculate the output corresponding to the value of the DAC data register 1160 of 525 as (525 * 3.3 / 4096) * 1000 ≈ 423mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by about 8.5mV per 1ms, enabling the DC power control unit 122 to boost the voltage by 2.8V per 1ms, lasting for 50ms. After uniformly changing 50 times, the voltage is boosted from 0V to 140V and maintained for 900ms. During the step-down process, t4 is 50ms, △V = -140V / 50ms = -2.8V / ms, that is, the electric field voltage drops by 2.8V per 1ms, lasting for 50ms, and the voltage is stepped down from 140V to 0V. The value of the DAC data register 1160 corresponding to the voltage of 140V is 525, and the variable △DAC of the DAC data register 1160 per unit time t is △DAC = 525 / 50 ≈ 11. The control device 110 decreases the value of the DAC data register 1160 by 11 per 1ms. The output corresponding to the value of the DAC data register 1160 of 4096 is 3.3V. Calculate the output corresponding to the value of the DAC data register 1160 of 525 as (525 * 3.3 / 4096) * 1000 ≈ 423mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by about 8.5mV per 1ms, enabling the DC power control unit 122 to step down the voltage by 2.8V per 1ms, lasting for 50ms. After uniformly changing 50 times, the voltage is stepped down from 140V to 0V.

[0142] From 1431s to 1432s, within the 716th cycle T, the alternating electric field voltage V in the Y direction t716 is 140V. That is, the alternating electric field voltage V in this direction t716 boosts from 0V to 140V and then steps down to 0V. For the specific output process, refer to the output process of the alternating electric field voltage of 140V in the aforementioned X direction, which will not be elaborated here.

[0143] When 140V ≤ V tn ≤ 160V, the alternating electric field voltage V tn is as described in the above boost method. The alternating electric field voltage V tnAfter reaching 140V, within the subsequent 250s (i.e., 125 cycles T), the alternating electric field voltage V tn maintains an output of 140V to wait for the target area to adapt to the current electric field strength, and at the same time waits for the temperature of electrode 130 to rise. The maintenance time of 250s is used to eliminate the phenomenon of temperature lag of electrode 130. Then it gradually increases from 140V until the alternating electric field voltage V tn rises by 5V to reach 145V. Within the subsequent 250s (i.e., 125 cycles T), the alternating electric field voltage V tn maintains an output of 145V to wait for the target area to adapt to the current electric field strength, and at the same time waits for the temperature of electrode 130 to rise. The maintenance time of 250s is used to eliminate the phenomenon of temperature lag of electrode 130. Until the alternating electric field voltage V tn reaches 160V, and then according to the subsequent temperature detection situation, the alternating electric field voltage V tn is adjusted accordingly.

[0144] In short, the alternating electric field voltage V tn starting from reaching 140V, that is, stabilizing the output of 140V for 250s. Until during the period from 140V to 160V, the alternating electric field voltage V tn needs to maintain the current voltage output for 250s after each increase of 5V.

[0145] From 2510s to 2511s, within the 1256th cycle T, the X-direction alternating electric field outputs an alternating electric field voltage V t1256 of 160V. That is, the alternating electric field voltage V in this direction t1256Boost from 0V to 160V and then step down to 0V. Specifically, during the boost process, t3 is 50ms, △V = 160V / 50ms = 3.2V / ms, that is, the electric field voltage in this direction boosts by 3.2V per 1ms, lasting for 50ms, and the voltage is boosted from 0V to 160V. The value of the DAC data register 1160 corresponding to the voltage 160V is 600, and the variable △DAC of the DAC data register 1160 per unit time t is 600 / 50 = 12. The control device 110 increases the value of the DAC data register 1160 by 12 per 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. Calculate the output corresponding to the value 600 of the DAC data register 1160 as (600 * 3.3 / 4096) * 1000 ≈ 484mV. That is to say, the control device 110 increases the output of the DAC data register 1160 by about 9.6mV per 1ms to make the DC power control unit 122 boost by 3.2V per 1ms, lasting for 50ms. After 50 uniform changes, the voltage is boosted from 0V to 160V and maintained for 900ms. During the step-down process, t4 is 50ms, △V = -160V / 50ms = -3.2V / ms, that is, the electric field voltage drops by 3.2V per 1ms, lasting for 50ms, and the voltage is stepped down from 160V to 0V. The value of the DAC data register 1160 corresponding to the voltage 160V is 600, and the variable △DAC of the DAC data register 1160 per unit time t is 600 / 50 = 12. The control device 110 decreases the value of the DAC data register 1160 by 12 per 1ms. The output corresponding to the value 4096 of the DAC data register 1160 is 3.3V. Calculate the output corresponding to the value 600 of the DAC data register 1160 as (600 * 3.3 / 4096) * 1000 ≈ 484mV. That is to say, the control device 110 decreases the output of the DAC data register 1160 by about 9.6mV per 1ms to make the DC power control unit 122 step down by 3.2V per 1ms, lasting for 50ms. After 50 uniform changes, the voltage is stepped down from 160V to 0V.

[0146] From 2511s to 2512s, within the 1256th cycle T, the alternating electric field voltage V in the Y direction t1256 is 160V. That is, the alternating electric field voltage V in this direction t1256 boosts from 0V to 160V and then steps down to 0V. For the specific output process, refer to the output process of the alternating electric field voltage of 160V in the aforementioned X direction, which will not be elaborated here.

[0147] alternating electric field voltage V tn After reaching 160V, according to the subsequent temperature detection situation, the alternating electric field voltage V tn will be adjusted accordingly. The specific control scheme will be described in detail below.

[0148] When each electrode 130 is well applied, during the process of the alternating electric field voltage V tn starting from 0V at the beginning of treatment and slowly rising step by step to 160V through the above-mentioned steps, since the cumulative treatment time is short, the skin temperature at the application site of the electrode 130 will not exceed Tth1, that is, 40.4°C. Therefore, during the period when the alternating electric field voltage V tn reaches 160V, it is a continuous step-by-step voltage increase process and does not involve the step-down output of the tumor electric field treatment system 100.

[0149] In the tumor electric field treatment system 100, when the alternating electric field voltage V tn reaches 160V, the temperature of the corresponding electrode 130 will be detected once during the time interval when the alternating electric signal is stopped being applied to the corresponding pair of electrodes 130 in each period T. When the temperature of the electrode unit 210 exceeds Tth1, the current alternating electric field voltage Vtn will enter the step-down stage based on the current voltage. Specifically, the voltage difference between any two adjacent alternating electric field voltages V tn in the direction of the corresponding electric field application in two adjacent periods T is equal, and is set as V c3 , that is, the corresponding alternating electric field voltage V tn in the latter period T minus the corresponding alternating electric field voltage V tn in its previous period T is V c3 . In this embodiment, V c3 takes a value of -1V. In this case, the step-down speed in the step-down stage is the third speed S 3 =V c3 / T. Whenever the AC voltage drops by 10V, it enters the voltage maintenance stage to maintain the current AC voltage output for a duration of 180s. At this time, the heat generated by the reduction of the AC voltage decreases, and the temperature of the electrode 130 can be reduced. After maintaining for 180s, if the temperature of the electrode unit 210 still exceeds Tth1, it will enter the step-down stage again and repeat the above AC voltage adjustment process in the step-down stage and the maintenance stage after the step-down stage. During the step-down stage and the maintenance stage of the AC voltage, the tumor electric field treatment system 100 will detect the temperature of the corresponding electrode 130 once in each period T. When the temperature of the electrode 130 is lower than Tth3, the corresponding AC voltage will enter the aforementioned step-up stage based on the current voltage.

[0150] When some electrodes 130 are poorly applied, it will cause the impedance between the electrode 130 and the human body to become abnormally large, and further cause some corresponding electrodes 130 to heat up abnormally. During the process of the alternating electric field voltage V tn starting from 0V at the beginning of treatment and slowly rising step by step to 160V through the above-mentioned steps, there may also be some electrodes 130 whose temperatures exceed Tth1, and even exceed Tth2. Further, during the alternating electric field voltage V tnDuring the process from 0V at the start of treatment to 160V through the above-mentioned step-by-step slow voltage increase, the temperature of the corresponding electrode 130 is detected once during the time interval when the alternating electric signal is stopped being applied to the corresponding paired electrodes 130 within each cycle T. When the temperature of the electrode unit 210 exceeds Tth1, the current alternating electric field voltage V tn will enter the voltage reduction stage based on the current voltage. Specifically, for any two adjacent cycles T, the two alternating electric field voltages V tn in the direction of the corresponding electric field application have equal voltage differences, which are set to V c3 , that is, the corresponding alternating electric field voltage V tn in the latter cycle T minus the corresponding alternating electric field voltage V tn in its previous cycle T has a difference of V c3 . In this embodiment, the value of V c3 is -1V. In this case, the voltage reduction speed in the voltage reduction stage is the third speed S 3 =V c3 / T. Whenever the AC voltage drops by 10V, it enters the voltage maintenance stage to maintain the current AC voltage output for a duration of 180s. At this time, the heat generated by the reduction of the AC voltage decreases, and the temperature of the electrode 130 can be reduced. After maintaining for 180s, if the temperature of the electrode unit 210 still exceeds Tth1, it will enter the voltage reduction stage again and repeat the AC voltage adjustment process in the voltage reduction stage and the maintenance stage after the voltage reduction stage. During the AC voltage reduction stage and the maintenance stage, the tumor electric field treatment system 100 detects the temperature of the corresponding electrode 130 once in each cycle T. When the temperature of the electrode 130 is lower than Tth3, the corresponding AC voltage will be adjusted for corresponding voltage increase or maintenance according to the current alternating electric field voltage threshold range.

[0151] During the above-mentioned AC voltage increase stage, voltage reduction stage and maintenance stage, when the detected temperature of the electrode 130 exceeds Tth2, the tumor electric field treatment system 100 will stop the machine and stop the output of the alternating electric signal to prevent the temperature of the corresponding application area from being too high and causing scalding to the patient.

[0152] This application also provides a method for applying an alternating electric signal based on temperature, which is applied to the aforementioned tumor electric field treatment system 100. Referring to Figure 10 , this method includes:

[0153] Step 101: Start the tumor electric field treatment system 100;

[0154] Step 102: Alternately apply the AC voltage that increases step by step in cycles of T and uses V c1 as the voltage difference to the corresponding paired electrodes;

[0155] Step 103: Determine whether the AC voltage applied to each paired electrode is lower than Va1 When the AC voltage applied to the counter electrode is lower than V a1 then return to step 102 and continue to apply the AC voltage with V c1 as the voltage difference. When the AC voltage applied to the counter electrode is not lower than V a1 execute step 104;

[0156] Step 104: Determine whether there is an electrode unit temperature on each counter electrode higher than Tth1. When the electrode unit temperature on the counter electrode is higher than Tth1, execute step 120. When the electrode unit temperatures on the counter electrodes are not higher than Tth1, execute step 105;

[0157] Step 105: Determine whether the AC voltage applied to the corresponding counter electrode is lower than V a2 When the AC voltage applied to the corresponding counter electrode is lower than V a2 execute step 106. When the AC voltage applied to the corresponding counter electrode is not lower than V a2 execute step 107;

[0158] Step 106: Set the maintenance time t10 of the AC voltage after subsequent boosting of this counter electrode and execute step 112;

[0159] Step 107: Determine whether the AC voltage applied to the corresponding counter electrode is lower than V a3 When the AC voltage applied to the corresponding counter electrode is lower than V a3 execute step 108. When the AC voltage applied to the corresponding counter electrode is not lower than V a3 execute step 109;

[0160] Step 108: Set the maintenance time t20 of the AC voltage after subsequent boosting of this counter electrode and execute step 112;

[0161] Step 109: Determine whether the AC voltage applied to the corresponding counter electrode is lower than V a4 When the AC voltage applied to the corresponding counter electrode is lower than V a4 execute step 110. When the AC voltage applied to the corresponding counter electrode is not lower than V a4 execute step 111;

[0162] Step 110: Set the maintenance time t30 of the AC voltage after subsequent boosting of this counter electrode and execute step 112;

[0163] Step 111: Set the maintenance time t40 of the AC voltage after subsequent boosting of this counter electrode and execute step 112;

[0164] Step 112: Based on the current AC voltage, with V c2Continue to boost the voltage as the voltage difference and execute step 113;

[0165] Step 113: Determine whether the duration of continuous voltage boost reaches t50. After the duration of continuous voltage boost reaches t50, execute step 114. When the duration of continuous voltage boost does not reach t50, return to step 112;

[0166] Step 114: After the current AC voltage accumulatively boosts by V 1 enter the voltage boost waiting and maintaining state and execute step 115;

[0167] Step 115: Maintain the current AC voltage and execute step 116;

[0168] Step 116: Determine whether the waiting and maintaining duration reaches the set corresponding duration. When the waiting and maintaining duration reaches the corresponding duration, execute step 117. When the waiting and maintaining duration does not reach the corresponding duration, execute step 119;

[0169] Step 117: Determine whether the AC voltage applied to the corresponding pair of electrodes reaches V max When the AC voltage applied to the corresponding pair of electrodes reaches V max return to step 115. When the AC voltage applied to the corresponding pair of electrodes does not reach V max execute step 118;

[0170] Step 118: Continue to boost the voltage on the basis of the current AC voltage with V c2 as the voltage difference and return to step 104;

[0171] Step 119: Determine whether there is an electrode unit on the corresponding pair of electrodes whose temperature is higher than Tth1. When the temperature of the electrode unit on the pair of electrodes is higher than Tth1, execute step 120. When the temperature of the electrode unit on the pair of electrodes is not higher than Tth1, return to step 115;

[0172] Step 120: Determine whether there is an electrode unit on the corresponding pair of electrodes whose temperature is higher than Tth2. When the temperature of the electrode unit on the pair of electrodes is higher than Tth2, execute step 121. When the temperature of the electrode unit on the pair of electrodes is not higher than Tth2, execute step 122;

[0173] Step 121: The tumor electric field therapy system 100 shuts down and stops running;

[0174] Step 122: The tumor electric field therapy system 100 switches from the voltage boost state to the voltage drop state for the over-temperature pair of electrodes and executes step 123;

[0175] Step 123: The over-temperature pair of electrodes starts to drop the voltage on the basis of the current AC voltage with V c3 as the voltage difference and execute step 124;

[0176] Step 124: Determine whether the duration of continuous voltage reduction reaches t50. If the duration of continuous voltage reduction reaches t50, then execute Step 125. If the duration of continuous voltage reduction does not reach t50, return to Step 123;

[0177] Step 125: Accumulate the voltage reduction V 2 After that, enter the voltage reduction waiting and maintaining state and execute Step 126;

[0178] Step 126: Maintain the current AC voltage and execute Step 127;

[0179] Step 127: Determine whether the waiting and maintaining duration reaches t60. If the waiting and maintaining duration reaches t60, then execute Step 128. If the waiting and maintaining duration does not reach t60, then return to Step 126;

[0180] Step 128: Determine whether the temperatures of all electrode units on the corresponding paired electrodes are lower than Tth3. If the temperatures of all electrode units on the corresponding paired electrodes are lower than Tth3, execute Step 129. If there is an electrode unit on the corresponding paired electrodes whose temperature is not lower than Tth3, return to Step 123;

[0181] Step 129: The tumor electric field treatment system 100 switches from the voltage reduction state to the voltage increase state for the cooled paired electrodes and returns to Step 103.

[0182] Specifically, in Step 102, the voltage difference is the difference between the corresponding specific voltage Vtn in the latter cycle T and the corresponding specific voltage V in the previous cycle T within two adjacent cycles T; tn V c1 has a value range of 3V - 8V, preferably 5V.

[0183] In Step 103, V a1 has a value range of 70V - 90V, preferably 80V.

[0184] In Steps 104 and 119, the value range of Tth1 is 39.8°C - 40.5°C, preferably 40.4°C.

[0185] In Step 105, V a2 has a value range of 90V - 110V, preferably 100V.

[0186] In Step 106, the maintaining time t10 has a value range of 40s - 80s, preferably 60s.

[0187] In Step 107, V a3 has a value range of 110V - 130V, preferably 120V.

[0188] In step 108, the holding time t20 ranges from 80 s to 120 s, preferably 100 s.

[0189] In step 109, the value range of V a4 is from 130 V to 150 V, preferably 140 V.

[0190] In step 110, the holding time t30 ranges from 130 s to 170 s, preferably 150 s.

[0191] In step 111, the holding time t40 ranges from 230 s to 270 s, preferably 250 s.

[0192] In steps 112 and 118, the value range of V c2 is from 0.3 V to 0.7 V, preferably 0.5 V.

[0193] In steps 113 and 124, the value range of t50 is from 5 s to 15 s, preferably 10 s.

[0194] In step 114, the value range of V 1 is from 3 V to 8 V, preferably 5 V.

[0195] In step 119, the value range of Tth1 is from 39.8 °C to 40.5 °C, preferably 40.4 °C.

[0196] In step 120, the value range of Tth2 is from 40.8 °C to 41.2 °C, preferably 41 °C.

[0197] In step 123, the value range of V c3 is from -3 V to -0.8 V, preferably -1 V.

[0198] In step 125, the value range of V2 is from 8 V to 12 V, preferably 10 V.

[0199] In step 127, the value range of t60 is from 160 s to 200 s, preferably 180 s.

[0200] In steps 128 and 129, the value range of Tth3 is from 38 °C to 39.6 °C, preferably 39.5 °C.

[0201] Those skilled in the art can understand that Figure 1 and Figure 4 the tumor electro-field therapy system 100 and its components shown, such as the control device 110, are merely illustrative. In some embodiments, the tumor electro-field therapy system 100 may include more or fewer components.

[0202] The control method 200 for the tumor electric field therapy system 100 according to the present disclosure and the structure and operation of the control device 110 (and the electric field generating device 120) have been described above in conjunction with the accompanying drawings. However, those skilled in the art can understand that the execution of the steps and sub-steps of the method 200 is not limited to the order shown in the figures and described above, but can be executed in any other reasonable order. In addition, the tumor electric field therapy system 100 or the control device 110 does not necessarily include Figure 1 or Figure 4 all the components shown in

[0203] and may include only some of the components necessary to perform the functions described in the present disclosure, and the connection manners of these components are not limited to the forms shown in the figures.

[0204] In one or more exemplary designs, the functions described in the present disclosure can be implemented using hardware, software, firmware, or any combination thereof. For example, if implemented using software, the functions can be stored on a computer-readable medium as one or more instructions or codes, or transmitted as one or more instructions or codes on a computer-readable medium.

[0205] Each unit of the device disclosed herein can be implemented using discrete hardware components or can be integrally implemented on a hardware component such as a processor. For example, a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA), or other programmable logic devices, discrete gate or transistor logic, discrete hardware components, or any combination for performing the functions described herein can be used to implement or execute the various exemplary logic blocks, modules, and circuits described in conjunction with the present disclosure.

[0206] Those of ordinary skill in the art should also understand that the various exemplary logic blocks, modules, circuits, and algorithm steps described in conjunction with the embodiments of the present disclosure can be implemented as a combination of electronic hardware, computer software, or both.

[0207] The above description of the present disclosure is used to enable any ordinary person skilled in the art to implement or use the present disclosure. For those of ordinary skill in the art, various modifications to the present disclosure are obvious, and the general principles defined herein can also be applied to other variations without departing from the spirit and protection scope of the present disclosure. Therefore, the present disclosure is not limited to the examples and designs described herein, but is consistent with the broadest scope of the principles and novel features disclosed herein.

Claims

1. A control method for a tumor electric field treatment system, characterized in that: include: Determining a first voltage value between an initial voltage and a target voltage of an alternating electric field voltage of the tumor treatment field system; Between the initial voltage and the first voltage value, controlling the alternating electric field voltage of the tumor treatment field system to increase at a first speed; Between the first voltage value and the target voltage, controlling the alternating electric field voltage of the tumor electric field treatment system to increase at a second speed lower than the first speed; Dividing the first voltage value and the target voltage into a plurality of boost intervals by using a plurality of voltage threshold values; as well as In each of the plurality of boost intervals, the alternating electric field voltage of the tumor electric field therapy system is controlled to increase by a predetermined voltage value at the second speed for a predetermined period of time.

2. The control method according to claim 1, characterized in that: The plurality of voltage thresholds are evenly spaced between the first voltage value and the target voltage.

3. The control method according to claim 1, characterized in that: The plurality of voltage thresholds are distributed at unequal intervals between the first voltage value and the target voltage.

4. The control method according to claim 1, characterized in that: For every two adjacent voltage critical values ​​among the plurality of voltage critical values, the predetermined time periods are equal.

5. The control method according to claim 1, characterized in that: For every two adjacent voltage critical values ​​among the multiple voltage critical values, the predetermined time period is not equal and gradually increases as the voltage critical value increases.

6. The control method according to claim 1, characterized in that: In each of the plurality of boost intervals, controlling the alternating electric field voltage of the tumor electric field treatment system to increase by a predetermined voltage value at the second speed for a predetermined period of time further comprises: Between the first voltage value and the target voltage, the alternating electric field voltages in two directions of the tumor electric field treatment system are controlled to increase in sequence at the second speed.

7. The control method according to claim 6, characterized in that: In each of the plurality of boost intervals, controlling the alternating electric field voltage of the tumor electric field treatment system to increase by a predetermined voltage value at the second speed for a predetermined period of time further comprises: After each boosting interval, the alternating electric field voltage in any direction of the tumor electric field therapy system is controlled to increase the predetermined voltage value at the second speed and maintain it for the predetermined time period until it is boosted to the target voltage and maintained.

8. The control method according to claim 1, characterized in that: Also includes: Acquiring the electrode temperature of the tumor electric field treatment system; determining whether the electrode temperature is above a first temperature threshold; as well as In response to determining that the electrode temperature is higher than the first temperature threshold, the alternating electric field voltage of the tumor electric field therapy system is controlled to decrease at a third speed based on the current voltage value.

9. The control method according to claim 8, characterized in that: Also includes: determining whether the electrode temperature is above a second temperature threshold, wherein the second temperature threshold is greater than the first temperature threshold; as well as In response to determining that the electrode temperature is higher than the second temperature threshold, the alternating electric field voltage of the tumor treatment field system is controlled to return to the initial voltage.

10. A control device for a tumor electric field treatment system, characterized in that: include: at least one processor; as well as At least one memory, the at least one memory being coupled to the at least one processor and storing instructions for execution by the at least one processor, the instructions, when executed by the at least one processor, causing the computing device to perform the steps of the method according to any one of claims 1 to 9.

11. A tumor electric field treatment system, characterized in that: include: The control device as claimed in claim 10; an electric field generating device electrically connected to the control device; as well as At least two pairs of electrodes are electrically connected to the electric field generating device, wherein the control device controls the electric field generating device to alternately apply the alternating electric field voltage to the at least two pairs of electrodes.

12. The tumor electric field treatment system according to claim 11, characterized in that: Also includes: A temperature sensor is configured to detect an electrode temperature of at least one electrode of the at least two pairs of electrodes.

13. A computer-readable storage medium, characterized in that: A computer program code is stored thereon, and when the computer program code is executed, the control method according to any one of claims 1 to 9 is executed.

14. A computer program product, characterized in that The invention comprises a computer program which, when executed by a machine, performs the control method according to any one of claims 1 to 9.

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