Antibodies against monkeypox virus A35R protein, their preparation methods and applications
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INST OF MICROBIOLOGY CHINESE ACAD OF SCI
- Filing Date
- 2025-03-17
- Publication Date
- 2026-05-26
AI Technical Summary
Current technologies lack monkeypox virus antibodies with high affinity and good in vitro neutralization, making the prevention and control of monkeypox virus infection difficult, especially in non-endemic countries where the transmission routes are diverse and the virus mutates rapidly, and there is a lack of effective antiviral therapies.
An antibody against monkeypox virus A35R protein was developed. Specific memory B cells were obtained by screening fully humanized mice with antibodies. Multiple monkeypox virus A35R monoclonal antibodies, including A35R-9E4, A35R-9F8, A35R-10C4, A35R-10D5, A35R-10E7, A35R-10H6, A35R-18E2, and A35R-18H2, were prepared and purified, exhibiting strong binding ability and high in vitro neutralization.
These monoclonal antibodies have strong binding affinity and in vitro neutralization properties to monkeypox virus, effectively neutralizing the virus and providing in vivo protection, thus offering new product possibilities for the detection and treatment of monkeypox virus.
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