Active constant-speed treatment method for patients with neurodegenerative diseases and myasthenia

By combining drug treatment and active isospeed training, using real-time monitoring and adaptive impedance training to dynamically adjust the drug dose and training intensity, the lag and inefficiency problems in the treatment of neurodegenerative diseases and myasthenia in the prior art are solved, and the treatment effect and quality of life are significantly improved.

CN120148732APending Publication Date: 2025-06-13BEIHANG UNIV
View PDF 0 Cites 1 Cited by

Patent Information

Application Number
CN202510069776.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-16
Publication Date
2025-06-13

AI Technical Summary

Technical Problem

In the treatment of patients with neurodegenerative diseases and myasthenia, drug treatment lacks real-time monitoring methods, and it is difficult to dynamically adjust the dose and treatment course. Rehabilitation training lacks quantitative and scientific support. The isospeed training equipment is large in size, complex in operation, poor portability, and lacks real-time data feedback mechanisms, which affect rehabilitation efficiency and neurologic recovery.

Method used

An active isospeed treatment method for patients with neurodegenerative diseases and myasthenia is proposed. Combined with drug treatment and active isospeed training, dynamically adjusting drug dose and training intensity through real-time monitoring and adaptive impedance training, and personalized adjustment suggestions are provided using cloud data analysis.

Benefits of technology

Through the synergy between drug treatment and active isospeed training, the lag, subjectivity and inefficiency problems in traditional treatment are solved, and the treatment effect and quality of life of patients with neurodegenerative diseases and myopathy are significantly improved.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN120148732A_ABST
    Figure CN120148732A_ABST
Patent Text Reader

Abstract

The invention discloses an active constant-speed treatment and training method for patients with neurodegenerative diseases and myasthenia, and the method comprises the steps: promoting nerve remodeling through active constant-speed training, enabling the patients to use active constant-speed training equipment, and adjusting the training speed, the angle range and the impedance torque. The device activates a specific muscle group in a safe and controllable environment through an adaptive impedance training technology, gradually enhances training impedance to improve muscle strength, enhances muscle contraction efficiency through targeted training, promotes neural pathway reconstruction and improves nerve-muscle cooperative control ability, and thus achieves neural function recovery and improvement. Therefore, drug therapy provides neuroprotection and muscle function support for a patient, active constant-speed training further promotes the rehabilitation progress through accurate control and real-time feedback, and meanwhile, the flexibility and individuation of training are improved through the multi-mode man-machine interaction and cloud remote guidance functions, so that the rehabilitation effect of the patient is improved. And the treatment effect and life quality of patients with neurodegenerative diseases and myasthenia are improved.
Need to check novelty before this filing date? Find Prior Art

Description

Technical Field

[0001] The present invention relates to the technical field of myasthenia treatment, and particularly to an active isokinetic treatment method for neurodegenerative diseases and myasthenia patients. Background Art

[0002] Existing treatments for neurodegenerative diseases and myasthenia patients mainly rely on the combination of drugs and rehabilitation training. Drug treatment usually uses neuroprotective agents, muscle relaxants, etc., combined with rehabilitation means such as artificial-assisted standing training and joint stretching to improve the patient's function. In addition, isokinetic training equipment has been gradually applied to the field of sports rehabilitation, providing support for the recovery of neuromuscular function with its characteristics of quantitative detection and efficient training.

[0003] However, the existing technology has deficiencies. Drug treatment lacks real-time monitoring means, making it difficult to dynamically adjust the dosage and treatment course. The curative effect depends on the coordination of rehabilitation training, but the training is mainly based on manual guidance, lacking quantitative and scientific support. At the same time, isokinetic training equipment is large in size, complex in operation, and poor in portability, restricting its application in scenarios such as home. In addition, there is a lack of a real-time data feedback mechanism, making it difficult to accurately control the training intensity, and the effect evaluation is subjective, affecting the rehabilitation efficiency and the recovery of nerve function. Summary of the Invention

[0004] The present invention aims to solve at least one of the technical problems in the related art to some extent.

[0005] For this purpose, the object of the present invention is to propose an active isokinetic treatment method for neurodegenerative diseases and myasthenia patients, which can solve the deficiencies of the existing technology, that is, drug treatment lacks real-time monitoring means, making it difficult to dynamically adjust the dosage and treatment course, the curative effect depends on the coordination of rehabilitation training, but the training is mainly based on manual guidance, lacking quantitative and scientific support. At the same time, isokinetic training equipment is large in size, complex in operation, and poor in portability, restricting its application in scenarios such as home. In addition, there is a lack of a real-time data feedback mechanism, making it difficult to accurately control the training intensity, and the effect evaluation is subjective, affecting the rehabilitation efficiency and the recovery of nerve function.

[0006] To achieve the above object, the present invention proposes an active isokinetic treatment method for neurodegenerative diseases and myasthenia patients, including the following steps: S1. According to the type of neurodegenerative disease and the degree of myasthenia of the patient, select the following drug combinations: Drugs for promoting neuroprotection, including antioxidants, neurotrophic factors or neuroprotective agents, for slowing down neuronal degeneration; Muscle relaxants, for relieving muscle spasm and improving motor ability; Auxiliary drugs for enhancing nerve-muscle conduction function, including acetylcholinesterase inhibitors or other drugs that can improve nerve conduction efficiency; S2. Develop a personalized drug usage plan, specifically including: Dynamically adjust the drug dosage, and adjust the daily dosage according to the patient's weight, muscle strength measurement results, and treatment stage; Determine the drug taking time and cycle, and optimize the drug action time window by continuously monitoring the patient's muscle strength, nerve conduction function, and related biomarkers; S3. Combine drug treatment with rehabilitation training, where the rehabilitation training includes: Use an active isokinetic training device for targeted muscle strength training, and enhance the drug efficacy by improving the nerve-muscle coordination ability; During the patient's rehabilitation training, evaluate the drug treatment effect through real-time data feedback, and adjust the training intensity and drug combination plan if necessary; S4. Through remote monitoring and cloud data analysis, regularly evaluate the patient's treatment progress, and provide personalized adjustment suggestions based on the data to ensure the synergistic effect of drug treatment and rehabilitation training.

[0007] The active isokinetic treatment method for neurodegenerative diseases and myasthenia patients of the present invention, the synergistic effect of drug treatment and active isokinetic training, combined with technologies such as real-time monitoring, adaptive impedance training, and cloud dynamic adjustment, comprehensively solves the problems of lag, subjectivity, and low efficiency in traditional treatments. Drug treatment provides neuroprotection and muscle function support for patients, and active isokinetic training further promotes the rehabilitation progress through precise control and real-time feedback. At the same time, the multi-mode human-computer interaction and cloud remote guidance functions improve the flexibility and personalization of training. Generally speaking, the present invention significantly improves the treatment effect and quality of life of neurodegenerative diseases and myasthenia patients.

[0008] In addition, the active isokinetic treatment method for neurodegenerative diseases and myasthenia patients proposed above according to the present invention may also have the following additional technical features: Specifically, an active isokinetic training method for neurodegenerative diseases and myasthenia patients as described in claim 1, characterized by including the following steps: S1. Active isokinetic training promotes nerve remodeling. The patient uses an active isokinetic training device to adjust the training speed, angle range, and impedance torque. The device activates specific muscle groups in a safe and controllable environment through adaptive impedance training technology, gradually increases the training impedance to enhance muscle strength, and enhances the muscle contraction efficiency through targeted training, promoting the reconstruction of nerve pathways and the improvement of nerve-muscle coordination control ability, thereby achieving the restoration and improvement of nerve function; S2. Human-computer interaction muscle strength monitoring. The device is equipped with a torque sensor and an angle sensor to collect the torque and angle data of knee joint movement in real time. The data is transmitted to the supporting mobile application through a Bluetooth module, and provides the following interface: a. Gamification interface: Displays the knee joint extension angle and torque magnitude in a cartoon form, and at the same time scores according to each training, and the accumulated points are used as a reference for training effects; b. Real-time data display interface: Displays the changes in torque and angle during the training process in the form of curves or bar charts, facilitating the patient to intuitively understand the training performance; The said monitoring and feedback mechanism ensures that the patient can adjust the training actions and intensity in real time, improving the training accuracy and efficiency; S3. Dynamically adjust the rehabilitation plan. The mobile application allows the patient to flexibly set training parameters according to actual needs, including isokinetic speed, number of training sessions, and duration. The device is connected to the cloud system, and the therapist can access the patient's training data in real time through the cloud, including impedance torque, knee joint angle, and training performance. Based on the patient's real-time data, professional rehabilitation personnel provide remote guidance and dynamically adjust the training plan to ensure the optimization of training effects.

[0009] Specifically, the active isokinetic training device gradually increases the impedance training intensity to activate specific muscle groups and promote the neuroplasticity reconstruction of the nervous system, while enhancing the patient's muscle strength and endurance.

[0010] Specifically, the gamification interface is designed for child users. It shows the training effects through the interaction of cartoon characters, combines the scoring mechanism and incentive feedback to mobilize the patient's training enthusiasm.

[0011] Specifically, the real-time data display interface is designed for adult users. It shows the torque and angle of each knee joint movement through bar charts or curves, providing an intuitive reference for training data.

[0012] Specifically, the function of dynamically adjusting the rehabilitation plan is based on the cloud data analysis. The therapist optimizes the personalized rehabilitation plan in real time according to the patient's training performance and synchronously adjusts it through the mobile application.

[0013] Specifically, an active isokinetic treatment and its training method for neurodegenerative diseases and myasthenia patients, according to the combination of claims 1-6, is characterized in that, through the combined use of drug treatment and active isokinetic training, it further improves the effect of nerve function recovery, reduces the myasthenia symptoms of the patient, and delays the progression of the disease.

[0014] The additional aspects and advantages of the present invention will be partially given in the following description, partially will become obvious from the following description, or will be understood through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The above-mentioned and / or additional aspects and advantages of the present invention will become obvious and easy to understand from the following description of the embodiments in conjunction with the drawings, wherein: Figure 1It is a schematic diagram of the rehabilitation mechanism; Figure 2 It is a schematic diagram of the gamification interface; Figure 3 It is a schematic diagram of the real-time data display interface. Specific implementation manners

[0016] The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the accompanying drawings are exemplary and are intended to explain the present invention and should not be construed as limiting the present invention. On the contrary, the embodiments of the present invention include all variations, modifications, and equivalents falling within the spirit and scope of the appended claims.

[0017] The active isokinetic treatment method for neurodegenerative diseases and myasthenia patients according to the embodiments of the present invention will be described below in conjunction with the accompanying drawings.

[0018] As Figures 1-3 shown, the active isokinetic treatment method for neurodegenerative diseases and myasthenia patients according to the embodiments of the present invention, the drug treatment method of the present invention includes the following steps: (1) Select a drug combination according to the patient's condition, including drugs promoting neuroprotection (such as antioxidants, neurotrophic factors), muscle relaxants, and drugs enhancing neuro-muscular conduction function; (2) Dynamically adjust the drug dosage and usage cycle by monitoring the patient's muscle strength, nerve conduction function, and biomarkers; (3) Combine drug treatment with rehabilitation training to enhance the drug efficacy.

[0019] It should be noted that drug treatment provides a scientific basis for drug dosage adjustment by real-time monitoring of the patient's physiological indicators, such as serum neuroinflammatory factor levels and muscle strength changes. For example, for Parkinson's disease patients, dynamically adjusting the dosage of neurotrophic factors can effectively protect neurons and delay the progression of the disease. In addition, the combination with rehabilitation training can promote the maximization of the drug treatment effect, especially providing support during the recovery process of the patient's neuro-muscular function.

[0020] The active isokinetic training method of the present invention includes the following steps: (1) The patient uses an active isokinetic training device, which can adjust the training speed, angle range, and impedance torque to ensure accurate training intensity; (2) The device activates specific muscle groups by providing adaptive impedance to enhance muscle strength and promote the reconstruction of nerve pathways; (3) Real-time monitor the knee joint movement data and transmit the data to the mobile application through the Bluetooth module for the user to view the training performance.

[0021] It should be noted that this device dynamically adjusts the impedance level through the "adaptive impedance training technology", solving the problem that the fixed impedance of traditional training devices cannot adapt to the needs of patients. For example, for patients with mild myasthenia symptoms, the device can gradually increase the impedance, thereby activating more muscle fibers and promoting muscle strength enhancement. The miniaturized design of the device makes it suitable for home use, and combined with the real-time monitoring function, it ensures the safety and scientific nature of the patients' training.

[0022] The described human-computer interaction muscle strength monitoring method includes: (1) A gamified interface, mainly targeted at child users, with cartoon characters interacting with training actions, real-time displaying the knee joint angle and torque and providing feedback on scores; (2) A real-time data display interface, targeted at adult users, presenting training data in the form of curves or bar charts to help patients intuitively understand their training performance.

[0023] It should be noted that the gamified interface stimulates the training enthusiasm of child patients through cartoon interaction design and combined with real-time score feedback. For example, through the cartoon display of "kicking distance", the knee joint extension angle and torque are transformed into game elements. And the real-time data display interface enables adult patients to understand the training progress at any time and adjust their training actions according to the data through intuitive graphical display, improving the training efficiency.

[0024] The described rehabilitation plan dynamic adjustment method includes: (1) Adjusting training parameters through a mobile application, including isokinetic speed, number of repetitions per set, and training time; (2) Connecting the device to a cloud system, and the therapist remotely adjusts the rehabilitation plan through real-time data analysis; (3) Providing personalized guidance based on the patients' training data.

[0025] It should be noted that the rehabilitation plan dynamic adjustment function combines cloud real-time monitoring and data analysis capabilities. The therapist can provide remote guidance for patients based on the impedance torque and angle performance during the patients' training process. For example, in the rehabilitation training of patients with amyotrophic lateral sclerosis, the therapist can dynamically adjust the training intensity according to real-time data, thereby meeting the rehabilitation needs at different stages and improving the training effect.

[0026] Furthermore, the described active isokinetic training device activates specific muscle groups and promotes the neuroplasticity reconstruction of the nervous system by gradually increasing the impedance training intensity, while enhancing the muscle strength and endurance of patients.

[0027] It should be noted that when using the training device, the user needs to actively exert force. If no force is exerted, the device will not generate damping, and the device will not actively apply force to the limb during use, thus ensuring the safety of the training process. The patient selects an appropriate isokinetic level according to their own strength level (such as 45° / s, 60° / s, 90° / s, 120° / s, etc.), and actively exerts force to resist the device. The device provides adaptive resistance according to the speed level selected by the patient, stimulates the continuous activation of muscle fibers and promotes the remodeling of neural pathways, improving the rehabilitation efficiency.

[0028] Furthermore, the human-computer interaction function supports multi-mode data display, including a gamified interface and a real-time data display interface. The user can choose to display training data in a curve or bar chart and view the moment and angle changes of each knee joint extension in real time.

[0029] It should be noted that this function adapts to the needs of different patients through flexible multi-mode display. Combining with the disclosure, the gamified interface can stimulate the training interest of child patients, while the real-time data display interface provides scientific and quantitative training feedback for adult patients. This diverse design enhances the user experience and ensures that patients of different ages and training goals can achieve the best results.

[0030] Furthermore, the method further improves the effect of nerve function recovery, reduces the myasthenia symptoms of patients, and delays the progression of the disease through the combined use of drug treatment and active isokinetic training.

[0031] It should be noted that the synergistic effect of drug treatment and active isokinetic training comprehensively promotes the rehabilitation effect in a two-pronged manner. For example, drugs protect neurons and improve the nerve-muscle conduction efficiency, while active isokinetic training activates neural pathways through real-time data monitoring and gradually enhanced impedance training to achieve functional remodeling. The two complement each other and provide an efficient and scientific comprehensive treatment plan for patients.

[0032] In summary, the active isokinetic treatment method for neurodegenerative diseases and myasthenia patients in the embodiments of the present invention comprehensively solves the problems of lag, subjectivity, and low efficiency in traditional treatments through the synergistic effect of drug treatment and active isokinetic training, combined with technologies such as real-time monitoring, adaptive impedance training, and cloud dynamic adjustment. Drug treatment provides nerve protection and muscle function support for patients, and active isokinetic training further promotes the rehabilitation progress through precise control and real-time feedback. At the same time, the multi-mode human-computer interaction and cloud remote guidance functions improve the flexibility and personalization of training. Generally speaking, the present invention significantly improves the treatment effect and quality of life of patients with neurodegenerative diseases and myasthenia.

[0033] In the description of this specification, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0034] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples", etc. means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0035] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those of ordinary skill in the art can make changes, modifications, substitutions, and variations to the above embodiments within the scope of the present invention.

Claims

1. An active isokinetic treatment method for patients with neurodegenerative diseases and myasthenia, characterized in that: The following steps are involved: S1. Choose the following drug combination based on the type of neurodegenerative disease and degree of muscle weakness: Drugs that promote neuroprotection, including antioxidants, neurotrophic factors, or neuroprotectants, are used to slow neuronal degeneration; muscle relaxants, used to relieve muscle spasms and improve movement ability; Auxiliary drugs that enhance nerve-muscle conduction function, including acetylcholinesterase inhibitors or other drugs that can improve nerve conduction efficiency; S2. Develop a personalized medication plan, including: Dynamically adjust drug dosage, adjusting daily dose according to the patient's weight, muscle strength test results and treatment stage; Determine the time and cycle of drug administration, and optimize the drug's action time window by continuously monitoring the patient's muscle strength, nerve conduction function, and related biomarkers; S3. Combine drug treatment with rehabilitation training, where the rehabilitation training includes: Use active isokinetic training equipment to conduct targeted strength training to enhance drug efficacy by improving neuromuscular synergy; During patient rehabilitation training, the effectiveness of drug treatment is evaluated through real-time data feedback, and the training intensity and drug combination regimen are adjusted when necessary; S4. Through remote monitoring and cloud data analysis, the patient's treatment progress is regularly evaluated, and personalized adjustment suggestions are provided based on the data to ensure the synergistic effect of drug treatment and rehabilitation training.

2. An active isokinetic training method for patients with neurodegenerative diseases and myasthenia as claimed in claim 1, characterized in that: The following steps are involved: S1. Active isokinetic training promotes neural remodeling. Patients use active isokinetic training equipment to adjust the training speed, angle range and impedance torque. The equipment activates specific muscle groups in a safe and controllable environment through adaptive impedance training technology, gradually increases training impedance to improve muscle strength, and enhances muscle contraction efficiency through targeted training, promoting neural pathway reconstruction and improving neuromuscular synergistic control ability, thereby achieving neural function recovery and improvement; S2, Human-machine interactive muscle force monitoring, the device is equipped with torque sensor and angle sensor, real-time collection of knee joint movement torque and angle data, the data is transmitted to the supporting mobile phone application through the Bluetooth module, providing the following interface: a. Gamified interface: The knee extension angle and torque are displayed in cartoon form. Points are scored based on each training session, and accumulated points are used as a reference for training results. b. Real-time data display interface: Displays the changes in torque and angle during training in the form of curves or bar graphs, allowing patients to intuitively understand their training performance; The monitoring and feedback mechanism ensures that patients can adjust training movements and intensity in real time to improve training accuracy and efficiency; S3. Dynamic adjustment of rehabilitation programs. The mobile application allows patients to flexibly set training parameters according to actual needs, including isokinetic speed, number of training sessions and duration. The device is connected to the cloud system, and therapists can access patients' training data in real time through the cloud, including impedance torque, knee joint angle and training performance. Based on patients' real-time data, professional rehabilitation personnel can provide remote guidance and dynamically adjust training programs to ensure optimal training results.

3. The active isokinetic training method for patients with neurodegenerative diseases and myasthenia according to claim 2, characterized in that: Active isokinetic training equipment gradually increases the intensity of resistance training to activate specific muscle groups and promote neuroplastic reconstruction of the nervous system, while improving patients' muscle strength and endurance.

4. The active isokinetic training method for patients with neurodegenerative diseases and myasthenia according to claim 2, characterized in that: The gamification interface is designed for child users. It demonstrates the training effect through interactive cartoon characters and combines a scoring mechanism with motivational feedback to motivate patients to be more active in training.

5. The active isokinetic training method for patients with neurodegenerative diseases and myasthenia according to claim 2, characterized in that: The real-time data display interface is designed for adult users. It displays the torque and angle of each knee joint movement through a bar graph or curve, providing an intuitive training data reference.

6. The active isokinetic training method for patients with neurodegenerative diseases and myasthenia according to claim 2, characterized in that: The dynamic adjustment function of the rehabilitation plan is based on cloud data analysis. The therapist optimizes the personalized rehabilitation plan in real time according to the patient's training performance, and makes simultaneous adjustments through the mobile application.

7. An active isokinetic treatment and training method for patients with neurodegenerative diseases and myasthenia according to the combination of claims 1 to 6, characterized in that: Through the combined use of drug therapy and active isokinetic training, the effect of neurological function recovery can be further improved, the patient's muscle weakness symptoms can be reduced, and the progression of the disease can be delayed.

Citation Information

Cited By

  • Exercise data analysis system and method for amyotrophic lateral sclerosis assessment

    CN121583566A