Observation method for discussing curative effect of graphene acupoint patch on primary dysmenorrhea based on acupoint theory

Abstract

The invention discloses an observation method for discussing the curative effect of a graphene acupoint patch on primary dysmenorrhea based on the acupoint theory, and mainly relates to the technical field of traditional Chinese medicine external treatment. Comprising the following steps of: screening and grouping subjects: formulating a primary dysmenorrhea diagnosis standard, screening the subjects according to the standard, dividing the subjects into an experimental group and a control group according to a random number table method, and ensuring that the two groups have no statistical difference in baseline data such as age, disease course and disease severity. The beneficial effects of the invention are that specific acupoints are selected for application according to the acupoint theory. Graphene is used as a novel nano material, has excellent thermal conductivity, electrical conductivity and biocompatibility, and can quickly transfer energy to deep acupoints, promote qi and blood circulation and relieve dysmenorrhea symptoms. Meanwhile, specific acupuncture points such as Shenque, Guanyuan, Sanyinjiao and the like are selected for application, and deep understanding and understanding of etiology and pathogenesis of primary dysmenorrhea are achieved based on the theory of traditional Chinese medicine.

Description

Technical Field

[0001] The present invention relates to the technical field of external treatment methods in traditional Chinese medicine, and specifically to an observation method for the curative effect of graphene acupoint patches in treating primary dysmenorrhea based on acupoint theory. Background Technique

[0002] The statements in this part only provide background technical information related to the present invention and do not necessarily constitute prior art.

[0003] With the acceleration of the modern social life rhythm and the improvement of women's awareness of physiological health care, primary dysmenorrhea has become a health problem that cannot be ignored. Primary dysmenorrhea, also known as functional dysmenorrhea, refers to the abdominal pain during menstruation, which is usually related to the hormonal changes in the menstrual cycle and may affect women's learning, work and quality of life.

[0004] Traditional Chinese medicine attributes the occurrence of dysmenorrhea to factors such as qi stagnation and blood stasis, and accumulation of cold and dampness, and emphasizes relieving symptoms by regulating the balance of qi and blood and warming yang to dispel cold. Acupoint therapy is a commonly used method in traditional Chinese medicine for treating dysmenorrhea. By stimulating specific acupoints (or meridian points) of the human body, it can adjust visceral functions, improve blood circulation, and relieve pain. The application of acupoints has shown good curative effects in the treatment of various pathological states and has become an important part of traditional Chinese medicine clinical practice.

[0005] In recent years, with the development of science and technology and the continuous progress of materials science, graphene, as a new material with excellent electrical conductivity, thermal conductivity and mechanical properties, has attracted extensive attention. The application potential of graphene in the biomedical field is extensive, especially showing good prospects in drug delivery, tissue engineering and biosensors, etc.

[0006] Graphene acupoint patch is a new type of treatment array. By making a patch with graphene material and attaching it to the corresponding acupoints for therapy. This patch can not only relieve dysmenorrhea by adjusting local temperature and promoting blood circulation, but also realize the slow release and delivery of drugs through the biocompatibility of graphene itself, thereby enhancing the curative effect. Compared with traditional medical means, the treatment of dysmenorrhea with graphene acupoint patches has the advantages of simple operation, non-invasive, safe and comfortable, etc.

[0007] When observing the efficacy of graphene acupoint patches in the treatment of primary dysmenorrhea, the design of the research method is extremely important. On the one hand, researchers need to select appropriate acupoints to ensure the pertinence and effectiveness of the treatment. For example, commonly used acupoints such as Guanyuan (CV4) and Sanyinjiao (SP6) are used. On the other hand, reasonable cycle design and collation of the baseline characteristics of patients also provide guarantees for the efficacy observation. The specific observation method can adopt a randomized controlled trial (RCT). Dysmenorrhea patients are divided into an experimental group and a control group. The experimental group is treated with graphene acupoint patches, while the control group can use traditional application therapies, such as traditional Chinese medicine application and hot compress. The main indicators for efficacy observation include pain scores, quality of life evaluation, and related biochemical indicators.

[0008] The efficacy observation of graphene acupoint patches also needs to concern the comprehensiveness of the patient experience. Introducing pain scales and quality of life assessment scales and conducting comparative analysis before and after treatment can provide data support for the further optimization of the therapy. The feedback and subjective feelings of patients are equally important in the efficacy observation. By quantifying the satisfaction and compliance of patients, the durability of the treatment effect can be explored more deeply. Summary of the Invention

[0009] The purpose of the present invention is to provide a method for observing the efficacy of graphene acupoint patches in the treatment of primary dysmenorrhea based on acupoint theory. The method of the present invention uses graphene acupoint patches in the implementation of the treatment plan and selects specific acupoints for application according to acupoint theory. As a new type of nanomaterial, graphene has excellent thermal conductivity, electrical conductivity, and biocompatibility, and can quickly transfer energy to the deep part of the acupoints, promote the circulation of qi and blood, and relieve dysmenorrhea symptoms. At the same time, the selection of specific acupoints such as Shenque (CV8), Guanyuan (CV4), and Sanyinjiao (SP6) for application is also based on the in-depth understanding and recognition of the etiology and pathogenesis of primary dysmenorrhea in traditional Chinese medicine theory. This targeted treatment plan makes the treatment effect more significant and also reflects the individuation and precision of traditional Chinese medicine treatment.

[0010] To achieve the above object, the present invention is realized through the following technical solutions:

[0011] A method for observing the efficacy of graphene acupoint patches in the treatment of primary dysmenorrhea based on acupoint theory. Subject screening and grouping: Establish a diagnostic criterion for primary dysmenorrhea, screen subjects according to the criterion, and divide the subjects into an experimental group and a control group according to the random number table method to ensure that there are no statistical differences in the baseline data such as age, course of disease, and severity of the disease between the two groups;

[0012] Implementation of the treatment plan: Use graphene acupoint patches for the experimental group, and select specific acupoints such as Shenque (CV8), Guanyuan (CV4), and Sanyinjiao (SP6) for application according to acupoint theory, and clarify the application time, frequency, and course of treatment; The control group uses placebo acupoint patches with the same appearance but no graphene component, and applies them to the same acupoints in the same way.

[0013] Pain intensity assessment: Using the Visual Analogue Scale (VAS), before treatment, during each menstrual cycle of treatment, and after treatment, the subjects were asked to rate the pain intensity of their dysmenorrhea, and the results of each rating were accurately recorded;

[0014] Traditional Chinese medicine (TCM) syndrome scoring: A scoring scale covering common TCM syndromes of primary dysmenorrhea such as lower abdominal pain, distension, lumbosacral soreness, and fear of cold and cold limbs was formulated. Corresponding scores were given according to the severity of symptoms, and scoring statistics were carried out before and after treatment respectively.

[0015] Adopting a targeted quality of life scale: The Dysmenorrhea Impact Scale was selected to comprehensively evaluate the quality of life of the subjects before and after treatment from dimensions such as daily activities, work and study, social interaction, and emotions, and the score changes in each dimension were quantitatively analyzed.

[0016] Before application, the skin of the acupoints needs to be cleaned and disinfected, and a specific fixing method is used to ensure the stability of the acupoint patch on the acupoints and prevent it from falling off.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0018] The method of the present invention adopts strict criteria and the random number table method in the screening and grouping of subjects, ensuring that there are no statistical differences in baseline data such as age, course of disease, and severity of the disease between the experimental group and the control group, thereby improving the reliability and accuracy of the experimental results. This scientific method of subject screening and grouping lays a solid foundation for subsequent efficacy observation and data analysis.

[0019] The method of the present invention uses graphene acupoint patches in the implementation of the treatment plan and selects specific acupoints for application according to the theory of acupoints. As a new type of nanomaterial, graphene has excellent thermal conductivity, electrical conductivity, and biocompatibility, and can quickly transfer energy to the deep part of the acupoints, promote the circulation of qi and blood, and relieve dysmenorrhea symptoms. At the same time, the selection of specific acupoints such as Shenque, Guanyuan, and Sanyinjiao for application is also based on the in-depth understanding and recognition of the etiology and pathogenesis of primary dysmenorrhea in traditional Chinese medicine theory. This targeted treatment plan makes the treatment effect more significant and also reflects the individualization and precision of traditional Chinese medicine treatment.

[0020] The method of the present invention uses a variety of evaluation tools and scales in the efficacy evaluation, including the Visual Analogue Scale (VAS), the TCM syndrome scoring scale, and the quality of life evaluation scale, etc. These evaluation tools and scales can comprehensively and objectively evaluate the changes in the pain intensity, TCM syndromes, and quality of life of the subjects from multiple dimensions, providing rich information and data support for efficacy observation and data analysis. This multi-dimensional evaluation method makes the efficacy evaluation more comprehensive and accurate, and also provides a strong basis for clinical decision-making.

[0021] The method of the present invention also focuses on the monitoring and recording of adverse reactions during the experiment. By detailedly recording the occurrence time, degree and treatment measures of adverse reactions such as skin allergies, swelling and itching, an adverse reaction evaluation system is established. This strict monitoring and timely treatment of adverse reactions not only ensures the safety of the subjects, but also provides a useful reference for further optimizing the treatment plan.

[0022] The method of the present invention uses statistical methods to analyze and process the collected data, and clarifies the significance level of data differences between different groups. This scientific statistical analysis method makes the results of efficacy observation more objective and reliable, and at the same time provides strong data support for verifying the effectiveness and superiority of graphene acupoint patches in the treatment of primary dysmenorrhea. Description of the Drawings

[0023] Appendix Figure 1 is the implementation and evaluation flowchart of the treatment plan for the method of observing the curative effect of graphene acupoint patches in the treatment of primary dysmenorrhea based on the acupoint theory of the present invention.

[0024] Appendix Figure 2 is the flowchart of adverse reaction detection in the present invention. Detailed Embodiments

[0025] The following further elaborates the present invention in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by this application.

[0026] What is described in the present invention is a method for observing the curative effect of graphene acupoint patches in the treatment of primary dysmenorrhea based on the acupoint theory, and the main structure includes

[0027] The specific implementation method of the method for observing the curative effect of graphene acupoint patches in the treatment of primary dysmenorrhea based on the acupoint theory is as follows:

[0028] Subject screening and grouping; First, formulate clear diagnostic criteria for primary dysmenorrhea, which should cover the main symptoms, signs and necessary medical examination results of dysmenorrhea. Then, select suitable subjects according to this standard to ensure that they meet the diagnostic requirements of primary dysmenorrhea.

[0029] Next, use the random number table method to randomly divide the subjects into an experimental group and a control group, and the number of subjects in each group should be equal or close to ensure the reliability of the experimental results. At the same time, the baseline data such as age, disease course, and disease severity of the two groups of subjects should be detailedly recorded and statistically analyzed to ensure that there are no statistical differences between the two groups in these aspects, so as to exclude the influence of other factors on the experimental results.

[0030] Implementation of the treatment plan; the subjects in the experimental group were treated with graphene acupoint patches. According to the theory of acupoints, specific acupoints such as Shenque, Guanyuan, and Sanyinjiao were selected as the application points. These acupoints are considered to be closely related to the occurrence and development of dysmenorrhea in traditional Chinese medicine theory. By applying graphene acupoint patches, these acupoints can be stimulated to achieve the purpose of regulating qi and blood, warming and dredging the meridians, and relieving pain.

[0031] Before application, the skin of the acupoints needs to be thoroughly cleaned and disinfected to avoid infections and other adverse reactions. Then, the graphene acupoint patches are accurately applied to the selected acupoints, and a specific fixation method is used to ensure the stability of the acupoint patches and prevent them from falling off during the application process. At the same time, the application time, frequency, and treatment course need to be clarified to ensure the effectiveness and safety of the treatment.

[0032] The subjects in the control group were applied with placebo acupoint patches that had the same appearance as the graphene acupoint patches but no graphene components. The patches were applied to the same acupoints in the same way to exclude the influence of other factors on the experimental results.

[0033] Efficacy evaluation; before treatment, during each menstrual cycle of treatment, and after the treatment, the visual analogue scale (VAS) was used to score the degree of dysmenorrhea pain of the subjects. The subjects scored the degree of pain according to their own feelings, and each scoring result was accurately recorded.

[0034] At the same time, a scoring scale covering common traditional Chinese medicine syndromes of primary dysmenorrhea such as lower abdominal pain, distension, lumbosacral soreness, and fear of cold and cold limbs was formulated, and corresponding scores were given according to the severity of the symptoms. Scoring statistics were carried out before and after treatment to evaluate the improvement of traditional Chinese medicine syndromes.

[0035] In addition, targeted quality of life scales such as the Dysmenorrhea Impact Inventory (DII) were also selected to comprehensively evaluate the changes in the quality of life of the subjects from dimensions such as daily activities, work and study, social interaction, and emotions. Quantitative analysis of the score changes in each dimension was carried out to evaluate the impact of the treatment on the quality of life of the subjects.

[0036] Adverse reaction monitoring; during the experiment, the possible adverse reactions of the subjects, such as skin allergy, redness, swelling, and itching, need to be closely monitored. The occurrence time, degree, and treatment measures of the adverse reactions are detailedly recorded, and an adverse reaction evaluation system is established. For the subjects who have severe adverse reactions, the treatment needs to be stopped in time and corresponding treatment measures need to be taken.

[0037] Data statistical analysis; finally, statistical methods were used to analyze and process the collected data. Statistical analysis methods include but are not limited to t-tests, analysis of variance, chi-square tests, etc. The significance level of the data differences between different groups was clarified to scientifically evaluate the efficacy observation results of graphene acupoint patches in the treatment of primary dysmenorrhea.

[0038] By comparing and analyzing various efficacy indicators of the experimental group and the control group, the effectiveness and superiority of the graphene acupoint patch based on acupoint theory in the treatment of primary dysmenorrhea can be verified. At the same time, it also provides a scientific basis for further clinical application and promotion.

[0039] The method of the present invention adopts strict criteria and the random number table method in the screening and grouping of subjects, ensuring that there are no statistical differences in baseline data such as age, disease course, and disease severity between the experimental group and the control group, thereby improving the reliability and accuracy of the experimental results. This scientific method of subject screening and grouping lays a solid foundation for subsequent efficacy observation and data analysis.

[0040] The method of the present invention uses a graphene acupoint patch in the implementation of the treatment plan and selects specific acupoints for application according to acupoint theory. As a new type of nanomaterial, graphene has excellent thermal conductivity, electrical conductivity, and biocompatibility, and can quickly transfer energy to the deep part of the acupoints, promoting qi and blood circulation and relieving dysmenorrhea symptoms. At the same time, the selection of specific acupoints such as Shenque, Guanyuan, and Sanyinjiao for application is also based on the in-depth understanding and recognition of the etiology and pathogenesis of primary dysmenorrhea in traditional Chinese medicine theory. This targeted treatment plan makes the treatment effect more significant and also reflects the individualization and precision of traditional Chinese medicine treatment.

[0041] The method of the present invention uses a variety of evaluation tools and scales in the efficacy evaluation, including the Visual Analogue Scale (VAS), the traditional Chinese medicine syndrome scoring scale, and the quality of life assessment scale, etc. These evaluation tools and scales can comprehensively and objectively evaluate the changes in aspects such as the pain degree, traditional Chinese medicine syndrome, and quality of life of the subjects from multiple dimensions, providing rich information and data support for efficacy observation and data analysis. This multi-dimensional evaluation method makes the efficacy evaluation more comprehensive and accurate, and also provides a strong basis for clinical decision-making.

Claims

1. Based on acupoint theory, the method for observing the efficacy of graphene acupoint patch in treating primary dysmenorrhea is explored, which is characterized by: include: Subject screening and grouping: Establish diagnostic criteria for primary dysmenorrhea, screen subjects according to the criteria, and divide subjects into experimental group and control group according to the random number table method to ensure that there is no statistical difference in baseline data such as age, disease course, and disease severity between the two groups; Implementation of the treatment plan: The experimental group was given graphene acupoint patches. According to acupoint theory, specific acupoints such as Shenque, Guanyuan, Sanyinjiao were selected for application, and the application time, frequency and course of treatment were clearly defined. The control group was given placebo acupoint patches with the same appearance but without graphene components, which were applied to the same acupoints in the same way.

2. The method for observing the efficacy of graphene acupoint patch in treating primary dysmenorrhea based on acupoint theory according to claim 1, characterized in that: Pain severity assessment: Using the visual analogue scale (VAS), the subjects rated their own dysmenorrhea pain severity before treatment, during each menstrual cycle and after treatment, and each rating result was accurately recorded; TCM syndrome scoring: A scoring scale covering common TCM syndromes of primary pain such as lower abdominal pain, heaviness, lumbar pain, chills and cold limbs was developed. Corresponding scores were given according to the severity of the symptoms, and the scores were statistically analyzed before and after treatment.

3. The method for observing the efficacy of graphene acupoint patch in treating primary dysmenorrhea based on acupoint theory according to claim 2 is characterized in that: Use targeted quality of life scale: Use the Dysmenorrhea Impact Scale to comprehensively evaluate the quality of life of the subjects before and after treatment from the dimensions of daily activities, work and study, social interaction, and emotions, and quantitatively analyze the changes in scores in each dimension.

4. The method for observing the efficacy of graphene acupoint patch in treating primary dysmenorrhea based on acupoint theory according to claim 3 is characterized in that: The skin of the acupoints needs to be cleaned and disinfected before application, and a specific fixing method should be used to ensure the stability of the patch on the acupoints to prevent it from falling off.

5. The method for observing the efficacy of graphene acupoint patch in treating primary dysmenorrhea based on acupoint theory according to claim 4 is characterized in that: In the S4 step, in addition to conventional indicators, a quality of life assessment scale is also included to comprehensively evaluate the patient's quality of life before and after treatment, including dimensions such as physiological function, psychological state, and social activities.

6. The method for observing the efficacy of graphene acupoint patch in treating primary dysmenorrhea based on acupoint theory according to claim 5, characterized in that: It also includes steps for monitoring adverse reactions during the experiment, recording in detail the time, extent and treatment measures of adverse reactions such as skin allergies, redness, swelling, itching, etc., and establishing an adverse reaction evaluation system.

7. The method for observing the efficacy of graphene acupoint patch in treating primary dysmenorrhea based on acupoint theory according to claim 6, characterized in that: A control group was set up, which used placebo acupoint patches or traditional treatment methods. The various efficacy indicators between the experimental group and the control group were compared and analyzed to verify the effectiveness and superiority of graphene acupoint patches based on acupoint theory in the treatment of primary dysmenorrhea.

8. The method for observing the efficacy of graphene acupoint patch in treating primary dysmenorrhea based on acupoint theory according to claim 7, characterized in that: Statistical methods are used to analyze the collected data, including but not limited to t-test, analysis of variance, chi-square test, etc., to clarify the significance of the differences in data between different groups in order to scientifically evaluate the efficacy observation results.

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