Photoionization ion mobility spectrometry for rapid switching of combined reagent ions and applications

By rapidly switching the photoionization ion mobility spectra of combined reagent ions and utilizing different airflow modes and reagent molecule switching devices, the problem of low ionization source efficiency in existing technologies has been solved, achieving highly sensitive and selective detection of substances with high proton affinity in complex matrices.

CN120164777BActive Publication Date: 2026-04-28DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
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Patent Information

Application Number
CN202311722842.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-12-14
Publication Date
2026-04-28
Estimated Expiration
2043-12-14

AI Technical Summary

Technical Problem

Existing ion mobility spectrometry sources have low ionization efficiency, making it difficult to achieve high selectivity and sensitivity for the detection of different samples, especially high proton affinity substances in complex matrices.

Method used

By rapidly switching the photoionization ion mobility spectra of combined reagent ions, and utilizing different airflow modes and reagent molecule switching devices, different reagent molecules such as C3H6O2 and (H2O)n+ can be combined to achieve highly sensitive and selective detection of different target substances in complex matrices.

Benefits of technology

It improves the detection sensitivity and selectivity for substances with high proton affinity in complex matrices, such as ammonia, hazardous chemical hydrazine, and plasticizer phthalates, and enables highly sensitive early warning of substances at extremely low concentrations and accurate quantitative detection of substances at high concentrations.

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Abstract

The present application relates to a kind of photoionization ion mobility spectrometry of fast switching combination reagent ion, including photoionization ion mobility spectrometry, reagent ion generation device, reagent molecule carrier gas is introduced to reagent molecule into the reaction zone of ion mobility spectrometry, different types of reagent ions can be obtained by switching different gas paths and reagent molecules in positive ion mode, and the reagent ions in conventional gas flow mode are mainly (C3H6O)2H + , after switching combination gas path device, new hydrate cluster reagent ion H3O (H2O) n + Is generated by the regulation of acetone and water reagent molecule, and the reactivity is higher, the sensitivity of target detection is higher, so that by switching different gas paths, the high sensitivity and high selectivity detection of target compound can be realized, such as the detection of exhaled air ammonia and atmospheric ammonia in complex matrix background, and any sample pretreatment process is not needed.
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