Preparation method and application of compound preparation

Abstract

The invention relates to the field of biological medicine, in particular to a preparation method and application of a compound preparation, and the compound preparation is prepared from the following raw materials in parts by mass: 10-15 parts of fructus evodiae, 10-15 parts of fructus psoraleae, 5-10 parts of semen cuscutae, 10-15 parts of fennel, 5-10 parts of fructus amomi, 10-15 parts of rhizoma cyperi, 10-15 parts of perillaseed, 10-15 parts of frankincense and 10-15 parts of myrrh. The fructus evodiae is used for dispelling cold coagulation and relieving arthralgia, the fructus psoraleae is used for strengthening the spleen, the semen cuscutae is used for tonifying the kidney, the fennel and the fructus amomi are used for strengthening the transportation and transformation functions of the spleen and the stomach, the rhizoma cyperi and the perillaseed are used for soothing the liver and regulating qi, and the frankincense and the myrrh are added for promoting qi circulation The hot compress bag, the acupoint patch and the massage essential oil prepared by the invention are mainly used for treating muscular pain, eliminating cold to stop pain, warming and activating meridians and tonifying liver and kidney, are used for treating the temporomandibular joint disorder, have the effect of treating both symptoms and root causes, and enhance the long-term effect of treating the temporomandibular joint disorder. Wide application prospects are realized.

Description

Technical Field

[0001] The present invention relates to the field of biomedicine, and particularly to a preparation method and application of a compound preparation. Background Art

[0002] Temporomandibular joint disorders (TMDs) are related diseases of tissues in the temporomandibular joint region, including joints, muscles, etc. It is the fourth most common cause of chronic pain in the population. TMDs have a high prevalence rate, affect mental health, and can also cause anxiety, depression, sleep disorders, etc. It greatly affects people's quality of life and significantly increases the social and economic burden. For patients with TMDs who present with joint and muscle pain, it is of great significance to create a targeted formula for application on the pain points and acupoints.

[0003] Evodia rutaecarpa is the dried nearly ripe fruit of Evodia rutaecarpa, Evodia rutaecarpa var. officinalis or Evodia rutaecarpa var. bodinieri of the Rutaceae family. It is warm in nature, pungent and bitter in taste, and belongs to the liver, spleen, stomach and kidney meridians. Its functions are: dispersing cold and relieving pain, descending adverse qi and stopping vomiting, assisting yang and stopping diarrhea, and is used for headache due to cold pathogen attacking jueyin meridian, abdominal pain due to cold hernia, beriberi due to cold dampness, and abdominal pain during menstruation; Psoralea corylifolia is the dried ripe fruit of Psoralea corylifolia of the Leguminosae family. It is warm in nature, pungent and bitter in taste, and belongs to the kidney, pericardium, spleen, stomach and lung meridians. It can tonify the kidney and strengthen bones, and strengthen the spleen yang. Cuscuta chinensis is a parasitic plant of the genus Cuscuta in the Convolvulaceae family. It can tonify both yang and yin, with the characteristics of being warm but not dry and tonifying without stagnation, and is a good medicine for gently tonifying the liver and kidney; Fructus Foeniculi is the dried ripe fruit of Foeniculum vulgare of the Umbelliferae family. It is warm in nature and belongs to the liver, kidney, spleen and stomach meridians. It has the functions of warming yang and dispelling cold, regulating qi and relieving pain, and is mainly used for treating stomach cold and vomiting, and low back pain; Fructus Amomi is the dried ripe fruit of Amomum villosum of the Zingiberaceae family. It is warm in nature, pungent in taste, and belongs to the spleen, stomach and kidney meridians. It has the functions of promoting digestion by removing dampness, warming the middle-jiao and strengthening the spleen, etc., and can treat symptoms such as disharmony between the liver and stomach, and distending pain due to qi stagnation; Cyperus rotundus and Perilla frutescens have the effect of soothing the liver and regulating qi; Olibanum and Myrrh have the effect of promoting qi circulation and relieving pain. The above several medicinal materials complement each other, playing the roles of dispersing cold and relieving pain, warming the meridian and dredging collaterals, and tonifying the liver and kidney. The drug action is mild and can enhance the long-term curative effect of treating temporomandibular joint disorders.

[0004] It is recorded in "Huangdi Neijing" that the liver dominates the tendons and the kidney dominates the bones. Tonifying the liver and kidney means tonifying the muscles and bones. The entire fascia of the body depends on the nourishment of liver blood. Only when the liver blood is sufficient can the fascia of the limbs obtain sufficient nutrition through "nourishing qi to the tendons". Only when the kidney qi is sufficient can the bone marrow be full, the muscles and bones be strong, and normal activities be maintained. The onset of temporomandibular joint disorders is related to muscle and bone strain. Previously, most of the prescriptions for treating joints and muscles mainly focused on promoting blood circulation to remove stasis and warming the meridian to dredge collaterals. However, these prescriptions are not strong enough in tonifying the liver and kidney. When used for modern patients with temporomandibular joint disorders, the clinical curative effect is poor and the condition is prone to recurrence.

[0005] Therefore, according to the related technologies described above, there is an urgent need to develop a preparation method and application of a compound preparation. Summary of the Invention

[0006] In view of this, the purpose of the present invention is to provide a preparation method and application of a compound preparation to solve the problems of poor clinical efficacy and easy recurrence of the disease course when used in modern patients with temporomandibular joint disorders in the prior art.

[0007] Based on the above purpose, the present invention provides a preparation method and application of a compound preparation.

[0008] A preparation method of a compound preparation includes the following steps:

[0009] Crush evodia rutaecarpa, psoralea corylifolia, cuscuta chinensis, fennel, amomum villosum, cyperus rotundus, perilla seed, frankincense, and myrrh into powder, sieve it, mix it, add water, stir well, decoct after mixing evenly, filter after decocting, and finally dry the filtrate to obtain the compound preparation.

[0010] Preferably, the mass ratio of evodia rutaecarpa, psoralea corylifolia, cuscuta chinensis, fennel, amomum villosum, cyperus rotundus, perilla seed, frankincense, and myrrh is 10 - 15:10 - 15:5 - 10:10 - 15:5 - 10:10 - 15:10 - 15:10 - 15:10 - 15.

[0011] Preferably, the mass ratio of the total mass of evodia rutaecarpa, psoralea corylifolia, cuscuta chinensis, fennel, amomum villosum, cyperus rotundus, perilla seed, frankincense, and myrrh to the mass of water is 1 - 1.5:0.8 - 1.3.

[0012] Preferably, the decocting process is to first boil at 70 - 80 °C and then decoct at 40 - 50 °C for 1 h.

[0013] Preferably, the filtration is carried out by mesh filtration; the drying temperature is 70 - 80 °C.

[0014] An application of a compound preparation, characterized in that the compound preparation is used to prepare hot compress packs, acupoint patches, and massage essential oils.

[0015] The preparation process of the hot compress pack is as follows:

[0016] Crush the compound preparation into powder, sieve it, and package it into a hot compress pack. It can be reused more than 20 times. Before each use, heat it by steaming over water for hot compress.

[0017] The preparation process of the acupoint patch is as follows:

[0018] Crush the compound preparation into powder, sieve it, and mix it with fresh honey to form a paste to obtain the acupoint patch.

[0019] The acupoint patch is applied to the painful point area and the acupoints and xi-cleft points of the corresponding meridians. When fresh honey and the compound preparation are mixed and become a supersaturated solution, it will crystallize into a white paste. When preparing the acupoint patch, the dosage of honey is controlled to maintain its supersaturated solution state, thereby improving the adhesion and absorption effect.

[0020] The preparation process of the massage essential oil is as follows:

[0021] After the compound preparation is ground into powder and sieved, it is extracted with essential oil to obtain the massage essential oil.

[0022] Preferably, the essential oil is any one of sweet almond oil and jojoba oil. A suitable base oil is selected according to different skin types, such as sweet almond oil or jojoba oil, to enhance skin absorption and comfort.

[0023] Preferably, the extraction is any one of ultrasonic extraction and steam distillation. Through extraction, a massage essential oil rich in active ingredients can be obtained, which can enhance the therapeutic effect, enable the efficacy of the drug to better penetrate into the skin, and thus improve pain and discomfort.

[0024] Advantages of the present invention:

[0025] The present invention provides a preparation method and application of a compound preparation. In the present invention, evodia fruit, psoralea fruit, dodder seed, fennel fruit, amomum fruit, cyperus rhizome, perilla seed, frankincense and myrrh are mixed to make a hot compress pack, acupoint patch and massage essential oil. Evodia fruit dispels cold and stops arthralgia pain, supplemented by psoralea fruit to strengthen the spleen, dodder seed to tonify the kidney, and fennel fruit and amomum fruit to enhance the function of the spleen and stomach in transportation and transformation, assisted by cyperus rhizome and perilla seed to soothe the liver and regulate qi, and added with frankincense and myrrh to promote qi circulation and relieve pain. The present invention can effectively relieve joint and muscle pain caused by temporomandibular joint disorder; the present invention promotes blood circulation by activating blood circulation to remove stasis, achieving the effect of dispelling cold and relieving pain; the components in the present invention also have the effects of warming the meridian and dredging collaterals, improving blood circulation disorder caused by cold-dampness, and thus reducing pain; through the combination of multiple medicinal materials, the present invention can enhance the liver and kidney functions in the body and improve related symptoms caused by liver and kidney deficiency; through the overall combination in the formula, the present invention can not only relieve the existing symptoms of patients, but also improve the overall health level of patients to a certain extent and reduce the possibility of repeated disease courses;

[0026] The present invention is mainly used for treating muscle pain, dispelling cold and relieving pain, warming the meridian and dredging collaterals. Compared with the prior art, it can tonify the liver and kidney, enhance the long-term effect of treating temporomandibular joint disorder, and has a simple preparation method, can reduce production costs, meet the needs of different patients, is convenient to use, and has a wide application prospect. Specific embodiments

[0027] To make the purpose, technical solution and advantages of the present invention clearer, the following further elaborates on the present invention in detail with specific embodiments.

[0028] Example 1: A preparation method of a compound preparation, comprising the following steps:

[0029] Pulverize 10 g of Evodia rutaecarpa, 10 g of Psoralea corylifolia, 5 g of Cuscuta chinensis, 10 g of Foeniculum vulgare, 5 g of Amomum villosum, 10 g of Cyperus rotundus, 10 g of Perilla frutescens, 10 g of Olibanum, and 10 g of Myrrha, sieve the powder, mix it, add 64 g of water, and stir well. After stirring evenly, first boil it at 70 °C, then decoct it at 40 °C for 1 h. After decocting, filter it with a wire mesh, and finally dry the filtrate at 70 °C to obtain the compound preparation.

[0030] Example 2: A preparation method of a compound preparation, comprising the following steps:

[0031] Pulverize 11 g of Evodia rutaecarpa, 11 g of Psoralea corylifolia, 6 g of Cuscuta chinensis, 11 g of Foeniculum vulgare, 6 g of Amomum villosum, 11 g of Cyperus rotundus, 11 g of Perilla frutescens, 11 g of Olibanum, and 11 g of Myrrha, sieve the powder, mix it, add 73 g of water, and stir well. After stirring evenly, first boil it at 72 °C, then decoct it at 42 °C for 1 h. After decocting, filter it with a wire mesh, and finally dry the filtrate at 80 °C to obtain the compound preparation.

[0032] Example 3: A preparation method of a compound preparation, comprising the following steps:

[0033] Pulverize 12 g of Evodia rutaecarpa, 12 g of Psoralea corylifolia, 7 g of Cuscuta chinensis, 12 g of Foeniculum vulgare, 7 g of Amomum villosum, 12 g of Cyperus rotundus, 12 g of Perilla frutescens, 12 g of Olibanum, and 12 g of Myrrha, sieve the powder, mix it, add 82 g of water, and stir well. After stirring evenly, first boil it at 74 °C, then decoct it at 44 °C for 1 h. After decocting, filter it with a wire mesh, and finally dry the filtrate at 75 °C to obtain the compound preparation.

[0034] Example 4: A preparation method of a compound preparation, comprising the following steps:

[0035] Pulverize 13 g of Evodia rutaecarpa, 13 g of Psoralea corylifolia, 8 g of Cuscuta chinensis, 13 g of Foeniculum vulgare, 8 g of Amomum villosum, 13 g of Cyperus rotundus, 13 g of Perilla frutescens, 13 g of Olibanum, and 13 g of Myrrha, sieve the powder, mix it, add 91 g of water, and stir well. After stirring evenly, first boil it at 76 °C, then decoct it at 46 °C for 1 h. After decocting, filter it with a wire mesh, and finally dry the filtrate at 72 °C to obtain the compound preparation.

[0036] Example 5: A preparation method of a compound preparation, comprising the following steps:

[0037] Mix 14 g of Evodia rutaecarpa, 14 g of Psoralea corylifolia, 9 g of Cuscuta chinensis, 14 g of Foeniculum vulgare, 9 g of Amomum villosum, 14 g of Cyperus rotundus, 14 g of Perilla frutescens, 14 g of Olibanum, and 14 g of Myrrha into powder, sieve them, mix them together, add 99 g of water, and stir well. After stirring evenly, first boil at 78 °C, then decoct at 48 °C for 1 h. After decocting, filter with a wire mesh, and finally dry the filtrate at 73 °C to obtain a compound preparation.

[0038] Example 6: A preparation method of a compound preparation, comprising the following steps:

[0039] Mix 15 g of Evodia rutaecarpa, 15 g of Psoralea corylifolia, 10 g of Cuscuta chinensis, 15 g of Foeniculum vulgare, 10 g of Amomum villosum, 15 g of Cyperus rotundus, 15 g of Perilla frutescens, 15 g of Olibanum, and 15 g of Myrrha into powder, sieve them, mix them together, add 95 g of water, and stir well. After stirring evenly, first boil at 80 °C, then decoct at 40 - 50 °C for 1 h. After decocting, filter with a wire mesh, and finally dry the filtrate at 74 °C to obtain a compound preparation.

[0040] In the present invention, a compound preparation is obtained by mixing Evodia rutaecarpa, Psoralea corylifolia, Cuscuta chinensis, Foeniculum vulgare, Amomum villosum, Cyperus rotundus, Perilla frutescens, Olibanum, and Myrrha. Evodia rutaecarpa dispels cold and relieves arthralgia pain, supplemented by Psoralea corylifolia to strengthen the spleen, Cuscuta chinensis to tonify the kidney, and Foeniculum vulgare and Amomum villosum to enhance the function of the spleen and stomach in transportation and transformation. Assisted by Cyperus rotundus and Perilla frutescens to soothe the liver and regulate qi, and added with Olibanum and Myrrha to promote qi circulation and relieve pain.

[0041] In the present invention, after the compound preparation is ground into powder and sieved, it is encapsulated into a hot compress pack, and the hot compress pack can be reused more than 20 times. Before each use, heat it in water for hot compress; after the compound preparation is ground into powder and sieved, it is mixed with fresh honey to form a paste to obtain an acupoint patch, which is applied to the painful points and the acupoints and Xi-cleft points of the corresponding meridians. When fresh honey and the compound preparation are mixed and become a supersaturated solution, it will crystallize into a white paste. When preparing the acupoint patch, control the dosage of honey to maintain its supersaturated solution state, thereby improving the adhesion and absorption effect; after the compound preparation is ground into powder and sieved, it is extracted with essential oil to obtain massage essential oil. Select a suitable base oil according to different skin types, such as sweet almond oil or jojoba oil, which can enhance skin absorption and comfort. The massage essential oil rich in active ingredients can be obtained by ultrasonic extraction or steam distillation, which can enhance the therapeutic effect and make the efficacy of the drug better penetrate into the skin, thereby improving pain and discomfort.

[0042] The present invention promotes blood circulation by activating blood circulation and removing blood stasis, achieving the effects of dispelling cold and relieving pain; the components in the present invention also have the functions of warming meridians and dredging collaterals, improving poor blood circulation caused by cold and dampness, and thus alleviating pain; through the combination of various medicinal materials, the present invention can enhance the liver and kidney functions in the body and improve the related symptoms caused by liver and kidney deficiency; through the overall combination in the formula, the present invention can not only relieve the existing symptoms of patients, but also improve the overall health level of patients to a certain extent and reduce the possibility of recurrence of the disease course.

[0043] The present invention is mainly used for treating muscle pain, dispelling cold and relieving pain, warming meridians and dredging collaterals. Compared with the prior art, it can tonify the liver and kidney, enhance the long-term effect of treating temporomandibular joint disorders, and has a simple preparation method, which can reduce production costs, meet the needs of different patients, is convenient to use, and has a broad application prospect.

[0044] Those of ordinary skill in the art should understand that the discussion of any embodiment above is only exemplary and is not intended to imply that the scope of the present invention is limited to these examples; under the concept of the present invention, the technical features in the above embodiments or different embodiments can also be combined, the steps can be implemented in any order, and there are many other variations in different aspects of the present invention as described above, which are not provided in detail for the sake of brevity.

[0045] The invention is intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A method for preparing a compound preparation, characterized in that: The following steps are involved: Grind Evodia rutaecarpa, Psoralea corylifolia, Cuscuta australis, fennel, Amomum villosum, Cyperus rotundus, Perilla seed, frankincense and myrrh into powder, sieve and mix, add water and stir thoroughly, mix evenly and then boil, filter after boiling, and finally dry the filtrate to obtain a compound preparation.

2. The method for preparing the compound preparation according to claim 1, characterized in that: The mass ratio of the Evodia rutaecarpa, Psoralea corylifolia, Cuscuta australis, fennel, Amomum villosum, Cyperus rotundus, Perilla seed, frankincense and myrrh is 10-15:10-15:5-10:10-15:5-10:10-15:10-15:10-15:10-15:10-15.

3. The method for preparing the compound preparation according to claim 1, characterized in that: The mass ratio of the total mass of the cornus officinalis, psoralea corylifolia, dodder seed, fennel seed, amomum villosum, cyperus rotundus, perilla seed, frankincense and myrrh to water is 1-1.5:0.8-1.

3.

4. The method for preparing the compound preparation according to claim 1, characterized in that: The decoction process in step S1 is to first boil at 70-80° C. and then decoct at 40-50° C. for 1 hour.

5. The method for preparing the compound preparation according to claim 1, characterized in that: The filtration in step S1 is mesh filtration; the drying temperature is 70-80°C.

6. The use of the compound preparation according to any one of claims 1 to 5, characterized in that: The compound preparation is used for preparing hot packs, acupoint stickers and massage essential oils.

7. The use of the compound preparation according to claim 6, characterized in that: The preparation process of the hot bun is as follows: The compound preparation is ground into powder, sieved, and then packaged into hot packs; The hot pack is heated in water before each use for hot compress.

8. The use of the compound preparation according to claim 6, characterized in that: The preparation process of the acupuncture patch is as follows: The compound preparation is ground into powder and sieved, and then mixed with fresh honey into a paste to obtain an acupuncture point patch; The agent is ground into powder and sieved, and then mixed with fresh honey into a paste to obtain an acupoint patch, which is applied to the painful area and the acupoints and Xi points of the corresponding meridians.

9. The use of the compound preparation according to claim 6, characterized in that: The preparation process of the acupuncture patch is as follows: The compound preparation is powdered and sieved, and then extracted with essential oil to obtain massage essential oil; The essential oil is any one of sweet almond oil and jojoba oil; The extraction is any one of ultrasonic extraction and steam distillation.