Medical contrast agent exosmosis injury treatment system
By designing a medical contrast agent extravasation injury treatment system combining CT scanning and photobiological treatment, the problems of poor treatment effects and high risk of side effects in the prior art are solved, and precise treatment and safe operation of the contrast agent extravasation area are achieved.
Patent Information
- Application Number
- CN202510443381.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-10
- Publication Date
- 2025-06-20
AI Technical Summary
In the prior art, when dealing with extravasive damage to contrast agents in medical imaging departments, there are problems such as poor treatment effect, complex operation and high risk of side effects.
A medical contrast agent extravasation injury treatment system is designed. Using a light device with dense light sources combined with CT energy spectrum sequence scanning, the light intensity and light time of the light device are adjusted to achieve accurate photobiotherapy in the contrast agent extravasation area by analyzing the iodine contrast agent extravasation image of the patient's limb.
The system can achieve accurate and targeted treatment of the extravasation area of the contrast agent, reduce treatment side effects, improve treatment efficiency, and nurses can operate directly and use safely.
Smart Images
Figure CN120168880A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of medical technologies, and particularly to a treatment system for contrast agent extravasation injury in the medical imaging department. Background Art
[0002] The global demand for CT enhanced scans has shown exponential growth. The annual number of CT examinations in the United States exceeds 75 million cases (50% of which require contrast agent injection), and the annual injection volume in South Korea reaches 4×10 6 cases. In China, with the aging of the population and the increasing burden of chronic diseases such as cardiovascular and cerebrovascular diseases and malignant tumors, the usage of contrast agents has shown a significant growth trend. As an enhanced examination drug for imaging diagnosis, iodinated contrast media (ICM) can change tissue contrast, accurately observe blood vessels, internal organs and organs, and is more likely to distinguish normal tissues and disease areas. Its development has undergone a technological iteration from ionic type (osmotic pressure > 1500 mOsm / kg H2O) to non-ionic type (osmotic pressure 580 - 800 mOsm / kg H2O) [2], but extravasation always remains an important clinical risk.
[0003] Modern CT enhancement technology relies on precise pharmacokinetic control. The total iodine amount (300 - 400 mgI / mL) and the injection flow rate (3 - 6 mL / s) jointly determine the peak of vascular enhancement. An optimized flow rate of 4 - 5 mL / s is recommended for coronary CTA to achieve visualization of coronary artery branches. Although the high-pressure injection system significantly improves the flow rate control accuracy compared with manual injection, the risk of mechanical venous injury has increased the incidence of contrast agent extravasation (ECM) to 0.1% - 1.2% reported abroad and 0.31% - 2.38% reported in China. ECM is defined as the abnormal leakage of ICM injected into the blood vessel into the subcutaneous / tissue space, and its occurrence degree is significantly positively correlated with the solution osmotic pressure, injection flow rate and venous elastic modulus.
[0004] The clinical manifestations of ECM present a dose-dependent pathological process: mild manifestations are local pain and inflammatory swelling; in moderate to severe cases, epidermal blisters can develop within 48 hours and subcutaneous tissue necrosis and compartment syndrome (requiring emergency fasciotomy) can develop within 72 hours. Multiple regression analysis shows that the independent risk factors for ECM include: ① patient factors: female (OR = 1.541), age (OR = 1.008), diabetic microangiopathy (OR = 2.265); ② technical factors: injection flow rate > 3 mL / s (OR = 6.073); ③ pathological factors: malignant tumor chemotherapy (OR = OR = 0.394), venous thrombosis (OR = 2.157) [9 - 10]. This complication not only leads to delays in diagnosis and treatment and increases medical costs, but also significantly reduces patient satisfaction with medical treatment.
[0005] The benzene ring structure of iodinated contrast media (ICM) endows it with significant cytotoxic characteristics, which can induce irreversible damage to renal epithelial cells, endothelial cells, and stem cells. Its toxicological mechanism mainly involves a cascade reaction mediated by reactive oxygen species (ROS): by activating mitochondrial-dependent oxidative stress, triggering the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) signaling pathways, leading to DNA double-strand breaks and lipid peroxidation of the cell membrane, and ultimately initiating the apoptosis program. It is worth noting that large-sample clinical studies have confirmed that contrast agent exposure can increase the DNA damage rate by 107% compared with the plain scan group (P < 0.01). At the same time, ROS significantly upregulates the expression of pro-inflammatory factors such as IL-1β, IL-6, and TNF-α by activating the NF-κB signaling axis, forming a synergistic amplification effect with the MAPK pathway, and jointly exacerbating cell necrosis and cytokine storm.
[0006] The osmotic pressure of commonly used clinical ICM reaches 2-3 times that of plasma osmotic pressure (280-320 mOsm / kg H2O). This hypertonic environment can induce the imbalance of the vascular endothelial cell membrane potential and cause cytoplasmic dehydration and shrinkage through the mechanism of osmotic shock. In vitro experiments show that hypertonic ICM can activate the NF-κB signal transduction pathway, promote the depolymerization of cytoskeletal proteins, disrupt the tight junction complex, and significantly increase vascular permeability (P < 0.05).
[0007] As a heterologous stimulant, ECM can activate pattern recognition receptors (PRRs), initiate the NF-κB signaling axis, and induce local vasodilation and leukocyte chemotaxis and infiltration. Activated macrophages produce IL-1β through the NLRP3 inflammasome, forming a positive feedback loop with TNF-α and IL-6, leading to the amplification of the inflammatory cascade. Morphological studies show that ICM exposure can increase the blurriness of the rabbit venous endothelial cell membrane boundary and reduce the microvillus density, significantly weakening the integrity of the vascular structure (P < 0.01).
[0008] Large-area extravasation (20-100 mL) can produce a significant mass effect, causing a sudden increase in tissue interstitial pressure, exceeding the critical threshold of capillary perfusion pressure. This change in the pressure gradient can lead to microcirculation disorders and trigger ischemia-reperfusion injury. Accounting for 10% of the extravasation, in severe cases, it can progress to compartment syndrome, accelerating the process of tissue ischemia and necrosis.
[0009] The high viscosity characteristics of ICM (4.7 - 11.8 mPa·s at 37°C) significantly delay the diffusion rate of interstitial fluid and prolong the exposure time of toxic substances. This retention effect synergizes with osmotic damage to establish a vicious cycle of "toxic accumulation - microcirculation disorder - tissue necrosis". After the pathological process peaks within 24 - 48 hours, it can persist to form chronic granulomatous inflammation lasting for 4 - 6 weeks.
[0010] In recent years, clinical intervention studies on iodine contrast agent extravasation have focused on three major fields: physical therapy, western medicine, and traditional Chinese medicine.
[0011] Traditional material therapy mainly involves elevating the affected limb combined with cold compress, but there are significant deficiencies at the implementation level. Existing studies show that key parameters such as the duration and frequency interval of cold compress are mostly based on clinical experience and lack evidence-based medical support. In practical operations, simple self-made devices (such as gloves or plastic bags) are commonly used for cold compress materials, resulting in problems such as low patient compliance and increased risk of local frostbite. More notably, there is currently no standardized cold compress protocol for quantitative research data on tissue repair.
[0012] Mucopolysaccharide polysulfate cream has become the preferred option in western medicine clinical applications due to its clear anti-inflammatory mechanism and swelling-eliminating effect. However, existing studies are mostly limited to single-center, small-sample observations, and there are still significant knowledge gaps in aspects such as drug penetration kinetics, dose-effect relationship, and optimization of combined treatment regimens.
[0013] Applying traditional Chinese medicine Jinhuang Powder externally can reduce the levels of inflammatory factors, but the compound preparation has complex components, an unclear effective material basis, and a risk of skin sensitization, severely restricting its clinical application and transformation.
[0014] Photobiomodulation has good application prospects in multiple medical treatment fields, especially in the treatment of extravasation of irritating drugs or phlebitis. Nurses can directly operate it with few side effects, but it is severely restricted in the treatment of iodine contrast agent extravasation in the imaging department due to the lack of suitable photobiological treatment equipment. Summary of the Invention
[0015] The objective of the present invention is to provide a contrast agent extravasation injury treatment system capable of performing photobiological treatment on the iodine extravasation area of patients.
[0016] A medical contrast agent extravasation injury treatment system for achieving the above objective of the present invention includes:
[0017] A lighting device densely distributed with multiple light sources;
[0018] A workbench supporting the lighting device;
[0019] And a light source power supply for supplying power to the multiple light sources in the lighting device;
[0020] A controller for adjusting the power supply parameters of a light source power supply to control a light irradiation device for performing photobiological therapy;
[0021] Wherein, the controller analyzes the iodine contrast agent extravasation image data of the patient's limb (such as the arm) obtained by CT energy spectrum sequence scanning, obtains parameters such as the light intensity and light irradiation time of the light irradiation device, and adjusts the light source power parameters by using the obtained light intensity and light irradiation time parameters, so as to control the light irradiation device to perform photobiological therapy on the extravasated patient.
[0022] Preferably, a plurality of light sources for performing photobiological therapy are densely arranged at equal intervals on the inner wall of the cylindrical outer shell of the light irradiation device.
[0023] Preferably, each light source is connected to the light source power supply through a bus, each light source is assigned an address, and the controller controls the light source power supply to supply power to the light source according to the address assigned to the light source.
[0024] Preferably, the controller also obtains light irradiation area parameters (such as the light irradiation area position, light irradiation area area, etc.) by analyzing the iodine contrast agent extravasation image of the patient's limb, and uses the light irradiation area parameters to select the light sources corresponding to the light irradiation area among the plurality of light sources in the light irradiation device as the light sources for photobiological therapy.
[0025] Preferably, a limb bracket for supporting the patient's limb is installed in the light irradiation device so as to always keep the patient's limb at the axis position of the light irradiation device.
[0026] Preferably, the limb bracket is an arc-shaped bracket, including a frame body and a support rod for supporting the frame body; the frame body of the arc-shaped bracket includes a plurality of arc-shaped rods distributed at intervals and a connecting rod for connecting the plurality of arc-shaped rods together.
[0027] Preferably, the connecting rod includes an upper connecting rod connecting the upper parts of the arc-shaped rods and a lower connecting rod connecting the bottom parts of the arc-shaped rods.
[0028] Preferably, the controller includes: an iodine area and thickness calculation module for the extravasation area, which is used to calculate the layer thickness of the iodine extravasation area according to the limb image from the CT energy spectrum sequence scanning; a light irradiation estimation module, which is used to estimate the light intensity and light irradiation time according to the calculated layer thickness of the iodine extravasation area; a voltage adjustment instruction module, which is used to generate an adjustment instruction for adjusting the working voltage of the light source power supply according to the estimated light intensity; a timing module, which is used to set the timing duration for the light source power supply to supply power to the light source according to the estimated light irradiation time, so as to control the light source power supply to supply power to the light source of the light irradiation device within this timing duration.
[0029] Preferably, the controller further includes: a light positioning module for determining a light position according to the area of the iodine contrast agent extravasation region from the calculation module; a light source selection module for selecting a light source corresponding to the determined light position according to the determined light position, so that the light source power supply supplies power to the selected light source.
[0030] Preferably, the controller further includes: a driver control module for controlling the movement of the limb bracket; an image analysis module for obtaining the in-place information of the limb bracket by analyzing the video image from the camera disposed inside the light irradiation device, so that the driver control module stops the movement of the limb bracket according to the in-place information of the limb bracket.
[0031] Preferably, the light positioning module determines the light irradiation region and area according to the distribution and area of the iodine contrast agent extravasation region of the patient, and determines the corresponding light position according to the light irradiation region and area.
[0032] Preferably, the light positioning module obtains the light irradiation region and light irradiation area including a plurality of light sources by placing a virtual cylindrical light irradiation model with a plurality of virtual light sources around the patient limb image showing the area of the iodine extravasation region of the patient.
[0033] The present invention has the following beneficial technical effects: 1) It can be directly operated by nurses and has small side effects; 2) It can achieve precise and targeted treatment of contrast agent extravasation; 3) It can perform photobiological treatment on all contrast agent extravasation regions of the patient at one time; 4) It can prevent the risk of burns to the human body during photobiological treatment; 5) It can automatically adjust the treatment position of the patient's contrast agent extravasation region. Description of the Drawings
[0034] Figure 1 is a schematic diagram of a medical contrast agent extravasation injury treatment system of the present invention;
[0035] Figure 2 is Figure 1 a left view of the contrast agent extravasation injury treatment instrument 100 in
[0036] Figure 3 is Figure 2 a schematic diagram of the first embodiment of the light irradiation device 110 in
[0037] Figure 4 is Figure 2 and Figure 3 a schematic diagram of the limb bracket 112 in
[0038] Figure 5 is an unfolded schematic diagram of the light source 118 installed on the inner wall of the light irradiation device;
[0039] Figure 6 is Figure 1 a schematic diagram of the first embodiment of the controller 200 in
[0040] Figure 7 is Figure 1 a schematic diagram of the second embodiment of the controller 200 in
[0041] Figure 8 a schematic diagram of selecting a light-illuminated area;
[0042] Figure 9 and Figure 10 is Figure 2 a schematic diagram of the second embodiment of the light-illuminating device 110 in
[0043] Figure 11 a schematic diagram of a control device applicable to the second embodiment of the light-illuminating device.
[0044] 100 - Contrast agent extravasation injury treatment instrument; 110 - Light-illuminating device; 111 - Light-illuminating device housing; 112 - Limb support; 113 - Arc rod; 114 - Support rod; 115 - Lower connecting rod; 116 - Upper connecting rod; 117 - Bottom plate; 118 - Light source; 120 - Workbench; 130 - Underframe; 140 - Driver; 141 - Hydraulic cylinder; 142 - Piston; 143 - Flange; 144 - Hydraulic cylinder base; 200 - Controller; Light source power supply 210; 300 - CT equipment. Detailed implementation manners
[0045] Low-intensity laser therapy (also known as photobiomodulation PBM) is a non-invasive therapy that uses non-ionizing light (low-power laser irradiation) to regulate cell functions. Through the interaction of light energy and biological tissues, it triggers photochemical reactions, promotes tissue repair, and thus reduces inflammation and alleviates pain.
[0046] Photobiomodulation interacts with photoreceptors of biological tissues through light quanta of specific wavelengths, inducing multi-cascade biological effects, and achieving beneficial regulations such as enhanced vascular endothelial function, normalization of cell membrane permeability, improvement of microcirculation, increase in capillary blood flow reserve, normalization of platelet aggregation characteristics, and normalization of the elasticity of red blood cells and the structure and function of the deformed red blood cell index.
[0047] The inventor of the present invention established an animal model of iodine contrast agent extravasation in the hind limbs of rabbits, and applied photobiomodulation to the pathological repair of iodine contrast agent extravasation, achieving good therapeutic effects.
[0048] Figure 1 Shows a medical contrast agent extravasation injury treatment system of the present invention, including a light-illuminating device 110, a workbench 120 for supporting the light-illuminating device 110, and a controller 200.
[0049] In one example, the controller 200 can be a CT device controller. By analyzing and processing the iodine contrast agent extravasation images of the patient's limb obtained from the CT 300 energy spectrum sequence scan, parameters such as the illumination intensity and illumination time of the illumination device 110 are obtained. Then, the illumination device is controlled to perform photobiological therapy on the patient using the obtained illumination intensity and illumination time.
[0050] In another example, the controller 200 can be a dedicated controller. By analyzing and processing the iodine contrast agent extravasation images of the patient's limb obtained from the CT 300 energy spectrum sequence scan, parameters such as the illumination intensity, illumination time, and illumination area of the illumination device 110 are obtained. Then, the illumination device is controlled to perform photobiological therapy on the iodine contrast agent extravasation site of the patient using the obtained illumination intensity, illumination time, and illumination area and other parameters.
[0051] Figures 2 - 5 Show the first embodiment of the illumination device 110. The illumination device 110 can be cylindrical or umbrella-shaped. The present invention preferably uses a cylindrical illumination device. On the inner wall of the illumination device housing 111, a plurality of light sources 118 for performing photobiological therapy are densely arranged at equal intervals, such as Figure 3 and Figure 5 shown.
[0052] Figure 5 Show the rectangular distribution diagram of the light sources 118 of the illumination device 110. Each light source 118 is connected to the light source power supply 210 through a bus. Each light source 118 is assigned an address such as 118-11, 118-1n, 118-n1, 118-nn, etc. The controller 200 controls the light source power supply 210 to supply power to the light source 118 according to the address of the light source 118.
[0053] In addition, the controller 200 can also select several light sources 118 for photobiological therapy according to the illumination area parameters, such as selecting Figure 8 the light sources 118 shown by the dotted line for photobiological therapy.
[0054] Such as Figure 2 and Figure 3 shown, a limb bracket 112 for supporting the patient's limb is installed in the illumination device 110. The limb bracket 112 can always keep the extravasation site of the patient at the central position of the illumination device 110, so that the distance between each light source 118 and the limb is basically equal, to improve the photobiological therapy effect. And it can also strictly control the epidermal temperature at 39.5 ± 0.5 °C during PBM treatment to prevent the risk of burns caused by the patient's limb contacting the light source 118.
[0055] The limb bracket 112 is an arc-shaped bracket, including a bracket body and a support rod 114 for supporting the bracket body. The arc-shaped bracket body includes a plurality of arc-shaped rods 113 distributed at intervals and connecting rods for connecting the plurality of arc-shaped rods 113 together, such as the upper connecting rod 116 and the lower connecting rod 115. The lower connecting rod 115 can be fixedly connected to the housing 111 of the lighting device.
[0056] Alternatively, the lower connecting rods 115 are also connected together through a bottom plate 117, and the front end and the rear end of the bottom plate 117 are fixedly connected to the housing 111 of the lighting device (such as by welding).
[0057] Figure 1 The function of the chassis 130 in [reference] is to raise the lighting device 110 so that it is convenient for the patient to insert the limb into the lighting device 110. Alternatively, the chassis 130 and the workbench can be combined into one object.
[0058] Figure 6 shows the first embodiment of the controller 200 of the lighting device 110 applicable to Figures 2 - 5 The controller 200 includes: a light source power supply for supplying power to the lighting device 110; an extravasation area iodine contrast agent area and thickness calculation module (abbreviated as the calculation module) for calculating the layer thickness of the iodine contrast agent extravasation area according to the limb image from the CT energy spectrum sequence scan 300; a light intensity estimation module for estimating the light intensity and the light time according to the calculated layer thickness of the iodine contrast agent extravasation area; a voltage adjustment instruction module for generating an adjustment instruction for adjusting the working voltage of the light source power supply according to the estimated light intensity; and a timing module for setting the timing duration for turning on the light source power supply according to the estimated light time, so as to control the light source power supply to supply power to the lighting device 110 during the timing duration.
[0059] The calculation module, the light intensity estimation module, the voltage adjustment instruction module, and the timing module of the controller 200 can all be implemented by the hardware and software of the CT device processor.
[0060] The light intensity estimation module estimates the light irradiation amount according to the layer thickness of the iodine contrast agent extravasation area, and then determines the light intensity and the light time according to the relationship of light irradiation amount = light intensity × light time. For example, when the light time is a fixed value, the light intensity is equal to the light irradiation amount divided by the fixed light time value, so as to adjust the voltage of the light source power supply according to the calculated light intensity; when the light intensity is a fixed value (when the light source voltage is a fixed value), the light time is equal to the light irradiation amount divided by the fixed light intensity value, so as to set the timing duration of the timing module according to the calculated light time. The light irradiation amount depends on the layer thickness of the iodine extravasation area, and the thicker the layer thickness of the iodine extravasation area, the more (greater) the light irradiation amount estimated by the light intensity estimation module.
[0061] In an example where the illumination time is a fixed value and the timing duration set by the timing module is a fixed value, the voltage adjustment instruction module stores a correspondence table between the illumination intensity and the light source voltage. When receiving the illumination intensity output by the illumination estimation module, it obtains the required light source voltage by looking up this correspondence table, and then generates a corresponding voltage adjustment instruction, which is sent to the light source power supply to adjust its working voltage to the required light source voltage.
[0062] In another example where the illumination time is a fixed value and the timing duration set by the timing module is a fixed value, the voltage adjustment instruction module determines the voltage adjustment instruction by comparing the illumination intensity output by the illumination estimation module with a preset illumination intensity threshold. For example, if the illumination intensity is greater than the illumination intensity threshold, the voltage adjustment instruction is determined as an instruction to increase the light source voltage; if the illumination intensity is less than or equal to the illumination intensity threshold, the voltage adjustment instruction is determined as an instruction to decrease the light source voltage. There can be multiple illumination intensity thresholds, such as a first illumination intensity threshold corresponding to a high light source voltage, a second illumination intensity threshold corresponding to a medium light source voltage, a third illumination intensity threshold corresponding to a low light source voltage, etc.
[0063] In an example where the illumination intensity is a fixed value and the voltage adjustment instruction module generates an adjustment instruction not to adjust the light source voltage, the timing module sets a timing duration equal to the illumination duration.
[0064] The light source power supply includes a power manager, which adjusts the working voltage of the light source power supply according to the adjustment instruction to adjust the light source voltage to the required value and supplies power to the light source 118 within the timing duration.
[0065] Figure 6 Shown applicable to Figures 2 - 5 The first embodiment of the controller 200 of the illumination device 110 can provide the most basic photobiological therapy effect.
[0066] Patients with iodine extravasation injury need to undergo multiple photobiological therapies using the medical imaging department contrast agent extravasation injury treatment system of the present invention. During each photobiological therapy, the patient's image is obtained by energy spectrum scanning of the CT system. The controller analyzes and calculates the patient's image to obtain the layer thickness of the iodine contrast agent extravasation area, and further calculates the illumination intensity and illumination time parameters based on the layer thickness of the contrast agent extravasation area. When the patient's limb extends into the illumination device 110 to prepare for photobiological therapy, the controller controls the light source of the illumination device 110 for photobiological therapy according to the calculated illumination intensity and illumination time parameters. The disadvantage of this embodiment is that both the iodine extravasation area and the normal area of the patient will receive photobiological therapy.
[0067] Figure 7 Shown applicable to Figures 2 - 5 The second embodiment of the controller 200 of the illumination device 110. As Figure 7As shown in the figure, the controller 200 includes: a light source power supply for supplying power to the lighting device 110; an iodine contrast agent extravasation area and thickness calculation module (hereinafter referred to as the calculation module) for calculating the area and layer thickness of the iodine contrast agent extravasation area based on the limb image from the CT energy spectrum sequence scan 300; a lighting positioning module for determining the lighting position based on the area of the iodine contrast agent extravasation area from the calculation module; a light source selection module for selecting a light source corresponding to the lighting position according to the determined lighting position and area; a lighting estimation module for estimating the lighting intensity and lighting time based on the calculated layer thickness of the iodine extravasation area; for generating an adjustment instruction for adjusting the working voltage of the light source power supply according to the estimated lighting intensity; a timing module for setting the timing duration as the lighting time with a timer according to the estimated lighting time, the timer controlling the light source power supply to supply power to the lighting device 110 and stopping the light source power supply from supplying power to the lighting device 110 after the timing expires.
[0068] The lighting positioning module can determine the lighting area of the light source 118 based on the distribution and area of the iodine contrast agent extravasation area of the patient, thereby determining the lighting position. For example, first, a virtual cylindrical lighting model with multiple virtual light sources is established, and the number and position of each virtual light source correspond one by one to the number and position of the light sources 118 in the lighting device 110; then, by placing the virtual cylindrical lighting model with multiple virtual light sources around the patient limb image showing the area of the iodine contrast agent extravasation area of the patient, the straight lines from the periphery of the iodine extravasation area on the patient limb image to the virtual light sources are used to determine the lighting area composed of multiple virtual light sources, such as Figure 8 the first lighting area composed of 12 virtual light sources and the second lighting area composed of 16 virtual light sources described above; a light source selection module for selecting the light source 118 corresponding to the lighting area according to the determined lighting area and connecting it to the light source power supply. For example, the light sources 118 in the 4th to 7th columns of the 3rd to 5th rows are selected as the first lighting area and connected to the light source power supply.
[0069] The lighting estimation module estimates the light irradiation amount based on the layer thickness of the iodine contrast agent extravasation area, and then determines the lighting intensity and lighting time according to the relationship of light irradiation amount = lighting intensity × lighting time. For example, when the lighting time is a fixed value, the lighting intensity is equal to the light irradiation amount divided by the fixed value of the lighting time, so as to adjust the voltage of the light source power supply according to the calculated lighting intensity; when the lighting intensity is a fixed value (when the light source voltage is a fixed value), the lighting time is equal to the light irradiation amount divided by the fixed value of the lighting intensity, so as to set the timing duration of the timing module according to the calculated lighting time. The light irradiation amount depends on the layer thickness of the iodine contrast agent extravasation area, and the thicker the layer thickness of the iodine contrast agent extravasation area, the more (greater) the light irradiation amount estimated by the lighting estimation module.
[0070] In an example where the illumination time is a fixed value and the timing duration set by the timing module is a fixed value, the voltage adjustment instruction module stores a correspondence table between the illumination intensity and the light source voltage. When the illumination intensity output by the illumination estimation module is received, the required light source voltage is obtained by looking up this correspondence table, and then a corresponding voltage adjustment instruction is generated and sent to the light source power supply to adjust its working voltage to the required light source voltage.
[0071] In another example where the illumination time is a fixed value and the timing duration set by the timing module is a fixed value, the voltage adjustment instruction module determines the voltage adjustment instruction by comparing the illumination intensity output by the illumination estimation module with a preset illumination intensity threshold. For example, if the illumination intensity is greater than the illumination intensity threshold, the voltage adjustment instruction is determined as an instruction to increase the light source voltage; if the illumination intensity is less than or equal to the illumination intensity threshold, the voltage adjustment instruction is determined as an instruction to decrease the light source voltage. There can be multiple illumination intensity thresholds, such as a first illumination intensity threshold corresponding to a high light source voltage, a second illumination intensity threshold corresponding to a medium light source voltage, a third illumination intensity threshold corresponding to a low light source voltage, etc.
[0072] In an example where the illumination intensity is a fixed value and the voltage adjustment instruction module generates an adjustment instruction not to adjust the light source voltage, the timing module sets a timing duration equal to the illumination duration.
[0073] The light source power supply includes a power manager. This power manager adjusts the working voltage of the light source power supply according to the adjustment instruction to adjust the light source voltage to the required value and supplies power to the light source 118 in the selected illumination area within the timing duration, for example, supplies power to the light sources in the first illumination area and the second illumination area, and lights all the light sources in the first illumination area and the second illumination area.
[0074] In this embodiment, during each photobiological therapy, the CT system's energy spectrum scan is used to obtain the patient's image. The controller analyzes and calculates the patient's image to obtain the position, area, and slice thickness of the area where the iodine contrast agent has extravasated in the patient. Based on the position and area of the area where the iodine contrast agent has extravasated in the patient, the illumination position and area parameters are determined, and then the corresponding light source 118 is selected according to the illumination position and area parameters; the illumination intensity and illumination time parameters are calculated based on the slice thickness of the contrast agent extravasation area. When the patient's limb extends into the illumination device 110 to prepare for photobiological therapy, the limb position needs to be adjusted so that the area where iodine has extravasated is aligned with the selected light source; then the controller controls the selected light source 118 to perform photobiological therapy according to the calculated illumination intensity and illumination time parameters. Figure 7 Shown applicable to Figures 2 - 5 The second embodiment of the controller 200 of the illumination device 110 can achieve precise and targeted treatment of the area where the iodine contrast agent has extravasated.
[0075] Figure 9 and Figure 10Shows the second embodiment of the illumination device of the present invention. The difference between this embodiment of the illumination device 110 and the first embodiment is that the limb support 112 is movably installed within the illumination device 110, and a driver 140 for moving the movable limb support 112 is provided on the workbench 120. A chute (not shown in the figure) is provided on the inner part of the housing of the illumination device 110, and the bottom plate 117 of the limb support 112 is installed in the chute for easy sliding.
[0076] The driver 140 includes a hydraulic cylinder 141, a hydraulic cylinder base 144 provided on the workbench 120 between the hydraulic cylinder 141, a piston 142 driven by the hydraulic cylinder 141 to perform telescopic movement, and a flange 143 fixed to the front end of the piston 142 and the rear end of the limb support 112.
[0077] The hydraulic cylinder 141 is controlled by the controller 200. By controlling the inflow and outflow of hydraulic oil in the rod chamber and the non-rod chamber of the hydraulic cylinder (which is a well-known technology), the position of the limb support 112 for supporting the patient's limb in the illumination device 110 is finely adjusted. In order to accurately adjust the limb position, a micro camera 145 can be installed on the inner wall of the illumination device 110, so that the controller 200 can finely adjust the limb support 112 according to the video image transmitted back by the camera 145. Figure 9 Shows the situation where the driver 140 drives the limb support 112 to move to the left, Figure 10 Shows the situation where the driver 140 drives the limb support 112 to move to the right.
[0078] Figure 11 Shows an example of the controller 200 applicable to the second embodiment of the illumination device 110. As Figure 11 shown, the controller 200 includes: a light source power supply for supplying power to the illumination device 110; an iodine extravasation area area and thickness calculation module (abbreviated as the calculation module) for calculating the iodine extravasation area area and layer thickness according to the limb image from the CT device 300; an illumination positioning module for determining the illumination position according to the iodine extravasation area area from the calculation module; a light source selection module for selecting a light source corresponding to the illumination position according to the determined illumination position; an illumination estimation module for estimating the illumination intensity and illumination time according to the calculated iodine extravasation area layer thickness; for generating an adjustment instruction for adjusting the working voltage of the light source power supply according to the estimated illumination intensity; a timing module for setting a timer with a timing duration equal to the illumination time according to the estimated illumination time, the timer controlling the light source power supply to supply power to the illumination device 110 and stopping the light source power supply from supplying power to the illumination device 110 after the timing expires; an image analysis module for obtaining the in-place information of the limb support 120 by analyzing the video image from the camera; a driver control module for controlling the operation of the driver 140.
[0079] During photobiological therapy, a mark is made on the patient's wrist or other part (such as pasting a label or applying a mark), and then the patient's limb is placed on the limb support 120. The driver 140 drives the limb support 120 to move towards the rear end or the back end of the light irradiation device 110. The camera 145 on the light irradiation device 110 takes pictures of the patient's limb and transmits the video image to the image analysis module.
[0080] In one example, the driver control module controls the reciprocating movement of the piston 141 of the driver 140; the image analysis module analyzes the video image taken by the camera. When it is determined that there is a patient mark in the normal image, a stop movement instruction is sent to the driver control module; the driver control module stops the operation of the driver 140 according to the stop movement instruction of the image analysis module.
[0081] The light irradiation positioning module can determine the light irradiation area of the light source 118 according to the distribution and area of the patient's iodine extravasation area, so as to determine the light irradiation position. For example, first, a virtual cylindrical light irradiation model with multiple virtual light sources is established, and the quantity and position of each virtual light source correspond one by one to the quantity and position of the light source 118 in the light irradiation device 110; then, by placing the virtual cylindrical light irradiation model with multiple virtual light sources around the patient limb image showing the area of the patient's iodine extravasation area, the straight lines from the periphery of the iodine extravasation area on the patient limb image to the virtual light sources are used to determine the light irradiation area composed of multiple virtual light sources, such as Figure 8 the first light irradiation area composed of 12 virtual light sources and the second light irradiation area composed of 16 virtual light sources as described; the light source selection module is used to select the light source 118 corresponding to the light irradiation area according to the determined light irradiation area and connect it to the light source power supply. For example, the light sources 118 in the 4th to 7th columns of the 3rd to 5th rows are selected as the first light irradiation area and connected to the light source power supply.
[0082] The light irradiation estimation module estimates the light irradiation amount according to the layer thickness of the iodine extravasation area, and then determines the light irradiation intensity and light irradiation time according to the relationship of light irradiation amount = light irradiation intensity × light irradiation time. For example, when the light irradiation time is a fixed value, the light irradiation intensity is equal to the light irradiation amount divided by the fixed value of the light irradiation time, so as to adjust the voltage of the light source power supply according to the calculated light irradiation intensity; when the light irradiation intensity is a fixed value (when the light source voltage is a fixed value), the light irradiation time is equal to the light irradiation amount divided by the fixed value of the light irradiation intensity, so as to set the timing duration of the timing module according to the calculated light irradiation time. The light irradiation amount depends on the layer thickness of the iodine extravasation area. The thicker the layer thickness of the iodine extravasation area, the more (larger) the light irradiation amount estimated by the light irradiation estimation module.
[0083] In an example where the illumination time is a fixed value and the timing duration set by the timing module is a fixed value, the voltage adjustment instruction module stores a correspondence table between the illumination intensity and the light source voltage. When receiving the illumination intensity output by the illumination estimation module, it obtains the required light source voltage by looking up this correspondence table, and then generates a corresponding voltage adjustment instruction, which is sent to the light source power supply to adjust its working voltage to the required light source voltage.
[0084] In another example where the illumination time is a fixed value and the timing duration set by the timing module is a fixed value, the voltage adjustment instruction module determines the voltage adjustment instruction by comparing the illumination intensity output by the illumination estimation module with a preset illumination intensity threshold. For example, if the illumination intensity is greater than the illumination intensity threshold, the voltage adjustment instruction is determined as an instruction to increase the light source voltage; if the illumination intensity is less than or equal to the illumination intensity threshold, the voltage adjustment instruction is determined as an instruction to decrease the light source voltage. There can be multiple illumination intensity thresholds, such as a first illumination intensity threshold corresponding to a high light source voltage, a second illumination intensity threshold corresponding to a medium light source voltage, a third illumination intensity threshold corresponding to a low light source voltage, etc.
[0085] In an example where the illumination intensity is a fixed value and the voltage adjustment instruction module generates an adjustment instruction not to adjust the light source voltage, the timing module sets a timing duration equal to the illumination duration.
[0086] The light source power supply includes a power manager, which adjusts the working voltage of the light source power supply according to the adjustment instruction to adjust the light source voltage to the required value and supplies power to the light source 118 in the selected illumination area within the timing duration, such as supplying power to the light sources in the first illumination area and the second illumination area, and lighting all the light sources in the first illumination area and the second illumination area.
[0087] Figure 11 The controller 200 of the second embodiment of the illumination device applicable to the display can automatically adjust the position of the contrast agent extravasation area of the patient's limb in the illumination device, realizing precise and targeted treatment of contrast agent extravasation.
[0088] In summary, a medical contrast agent extravasation injury treatment system of the present invention includes: an illumination device 110 densely arranged with a plurality of light sources 118; a workbench 120 supporting the illumination device 110; and a light source power supply 210 for supplying power to the plurality of light sources in the illumination device 110; a controller 200 for adjusting the power supply parameters of the light source power supply 210 to control the illumination device 110 to perform photobiological therapy; the controller 220 analyzes the iodine contrast agent extravasation image data of the patient's limb obtained by the CT300 energy spectrum sequence scan, obtains the illumination intensity and illumination time parameters of the illumination device 110, and adjusts the light source power supply parameters by using the obtained illumination intensity and illumination time parameters to control the illumination device 110 to perform photobiological therapy on the patient.
[0089] Among them, a plurality of light sources 118 for performing photobiological therapy are densely arranged at equal intervals on the inner wall of the cylindrical housing 111 of the lighting device 110.
[0090] Among them, each light source 118 is connected to the light source power supply 210 through a bus, and each light source 118 is assigned an address. The controller 200 controls the light source power supply 210 to supply power to the light source 118 according to the address assigned to the light source 118.
[0091] Among them, the controller 220 also obtains the illumination area parameters (such as the illumination area position, illumination area area, etc.) by analyzing the iodine contrast agent extravasation image data of the patient's limb, and uses the illumination area parameters to select the light source 118 corresponding to the illumination area among the multiple light sources in the lighting device 110 as the photobiological therapy light source.
[0092] Among them, a limb bracket 112 for supporting the patient's limb is installed in the lighting device 110, which is used to keep the patient's limb at the axis position of the lighting device 110 all the time.
[0093] Among them, the limb bracket 112 is an arc-shaped bracket, including a frame body and a support rod 114 for supporting the frame body; the frame body of the arc-shaped bracket includes a plurality of arc-shaped rods 113 distributed at intervals and a connecting rod for connecting the plurality of arc-shaped rods 113 together.
[0094] Among them, the connecting rod includes an upper connecting rod 116 connecting the upper part of the arc-shaped rod 113 and a lower connecting rod 115 connecting the bottom of the arc-shaped rod 113.
[0095] Among them, the controller 200 includes: an iodine contrast agent area and thickness calculation module in the extravasation area, which is used to calculate the layer thickness of the iodine extravasation area according to the limb image from the CT device 300; an illumination estimation module, which is used to estimate the illumination intensity and illumination time according to the calculated layer thickness of the iodine contrast agent extravasation area; a voltage adjustment instruction module, which is used to generate an adjustment instruction for adjusting the working voltage of the light source power supply according to the estimated illumination intensity; a timing module, which is used to set the timing duration for the light source power supply to supply power to the light source 118 according to the estimated illumination time, so as to control the light source power supply to supply power to the light source 118 of the lighting device 110 during this timing duration.
[0096] Among them, the controller 200 also includes: an illumination positioning module, which is used to determine the illumination position according to the area of the iodine contrast agent extravasation area from the calculation module; a light source selection module, which is used to select the light source 118 corresponding to the illumination position according to the determined illumination position, so that the light source power supply supplies power to the selected light source 118.
[0097] Among them, the controller 200 further includes: a driver control module for controlling the movement of the limb bracket 120; an image analysis module, which obtains the in-place information of the limb bracket 120 by analyzing the video images from the camera disposed inside the lighting device 110, so that the driver control module stops the movement of the limb bracket 120 according to the in-place information of the limb bracket 120.
[0098] Among them, the light positioning module determines the light area and area according to the distribution and area of the iodine contrast agent extravasation area of the patient, and determines the corresponding light position according to the light area and area.
[0099] Among them, the light positioning module obtains the light area and light area including a plurality of light sources by placing a virtual cylindrical light model with a plurality of virtual light sources around the patient limb image showing the area of the iodine contrast agent extravasation area of the patient.
[0100] Although the present invention has been described in detail above, the present invention is not limited thereto, and those skilled in the art of the present technology can make various modifications according to the principles of the present invention. Therefore, all modifications made according to the principles of the present invention should be understood to fall within the protection scope of the present invention.
Claims
1. A medical contrast agent extravasation injury treatment system, comprising: A lighting device (110) densely distributed with a plurality of light sources (118); A workbench (120) supporting the lighting device (110); A light source power supply (210) for supplying power to a plurality of light sources in the lighting device 110; A controller (200) for adjusting power supply parameters of a light source power supply (210) to control the illumination device (110) to perform photobiotherapy; The controller (220) obtains the illumination intensity and illumination time parameters of the illumination device (110) by analyzing the imaging data such as the iodine extravasation area and thickness of the patient's limbs obtained by CT (300) energy spectrum sequence scanning, and adjusts the light source power supply parameters using the obtained illumination intensity and illumination time parameters to control the illumination device (110) to perform photobiological treatment on the extravasation patient.
2. According to the medical contrast agent extravasation injury treatment system of claim 1, a plurality of light sources (118) for photobiotherapy are densely distributed at equal intervals on the inner wall of the cylindrical shell (111) of the illumination device (110).
3. According to the medical contrast agent extravasation injury treatment system of claim 2, each light source (118) is connected to the light source power supply (210) via a bus, each light source (118) is assigned a dedicated address, and the controller (200) controls the light source power supply (210) to supply power to the light source (118) according to the address assigned to the light source (118).
4. According to the medical contrast agent extravasation injury treatment system of claim 3, the controller (220) further obtains illumination area parameters by analyzing iodine extravasation images of the patient's limbs, and uses the illumination area parameters to select a light source (118) corresponding to the illumination area from among the multiple light sources in the illumination device (110) as a photobiotherapy light source.
5. According to the medical contrast agent extravasation injury treatment system according to claim 1 or 3, a limb support (112) for supporting the patient's limb is installed in the illumination device (110) to always keep the patient's limb in the center position of the illumination device (110).
6. According to the medical contrast agent extravasation injury treatment system of claim 5, the limb support (112) is an arc-shaped support, including a frame body and a support rod (114) supporting the frame body; the arc-shaped support frame body includes a plurality of arc-shaped rods (113) distributed at intervals and a connecting rod connecting the plurality of arc-shaped rods (113) together.
7. According to the medical contrast agent extravasation injury treatment system of claim 3, the controller (200) comprises: An iodine extravasation area and thickness calculation module is used to calculate the iodine extravasation area and layer thickness according to the limb image from the CT energy spectrum sequence scan 300; A light estimation module is used to estimate the light intensity and light exposure time according to the calculated iodine extravasation area and layer thickness; A voltage adjustment instruction module, used to generate an adjustment instruction for adjusting the operating voltage of the light source power supply according to the estimated light intensity; The timing module is used to set the timing duration for the light source power supply to supply power to the light source (118) according to the estimated illumination time, so as to control the light source power supply to supply power to the light source (118) of the illumination device (110) within the timing duration.
8. The medical contrast agent extravasation injury treatment system according to claim 7, wherein the controller (200) further comprises: An illumination positioning module, used for determining an illumination position according to the iodine extravasation area from the calculation module; The light source selection module is used to select a light source (118) corresponding to the illumination position according to the determined illumination position, so that the light source power supply supplies power to the selected light source (118).
9. The medical contrast agent extravasation injury treatment system according to claim 9, wherein the controller (200) further comprises: A driver control module for controlling the movement of the limb support (120); The image analysis module obtains information on the position of the limb support (120) by analyzing a video image from a camera disposed inside the illumination device (110), so that the driver control module stops the movement of the limb support (120) according to the information on the position of the limb support (120).
10. According to the medical contrast agent extravasation injury treatment system of claim 9, the illumination positioning module obtains the illumination region and illumination area including multiple light sources by placing a virtual cylindrical illumination model with multiple virtual light sources around the patient's limb image showing the area of the patient's contrast agent extravasation region.