Ultrasonic radiation force and sound field characterization method and device, equipment and storage medium

Abstract

The invention relates to the technical field of ultrasonic radiation force and sound field characterization, and discloses an ultrasonic radiation force and sound field characterization method and device, equipment and a storage medium, and the method comprises the steps: obtaining an adjustment signal; in response to the adjustment signal, adjusting the relative phase of the pair of interdigital transducers so as to control the movement of the particles and obtain the movement data of the particles in the microcavity; calculating a correction factor according to the state of the particle in the microcavity, the radius of the particle and the distance between the particle and the piezoelectric substrate of the interdigital transducer; based on the particle size, the speed, the accelerated speed and the movement time of the particles, the fluid viscosity of the microcavity and the correction factor, the ultrasonic radiation force borne by the particles in the microcavity is obtained through calculation; calculation is carried out based on the ultrasonic radiation force, the sound pressure in the microcavity is obtained, and the ultrasonic radiation force borne by the particles and the sound field in the microcavity can be represented through the particle size, the speed, the acceleration and the movement time of the particles, the fluid viscosity of the microcavity and the correction factor.

Description

Technical Field

[0001] The present invention relates to the technical field of ultrasonic radiation force and sound field, and particularly relates to a method, a device, a computer device and a storage medium for characterizing ultrasonic radiation force and sound field. Background Art

[0002] Objects in the sound field produce effects such as scattering, reflection, and absorption on sound waves, causing an exchange of momentum carried by the sound field with the objects, and thus generating a mechanical effect called ultrasonic radiation force. Ultrasonic radiation force is widely used in non-contact manipulation of particles.

[0003] The tip of a traditional hydrophone used to measure the sound field is generally larger than 200 microns, making it difficult to accurately characterize the complex sound field in a microchannel. Moreover, since the microchannel is a closed environment, it is difficult for the hydrophone to penetrate into the microchannel to measure the sound field, and thus it is difficult to characterize the ultrasonic radiation force exerted on the particles and the sound field in the microchannel. Summary of the Invention

[0004] Based on this, in view of the technical problem in the prior art that it is difficult to characterize the ultrasonic radiation force exerted on particles and the sound field in a microchannel, a method, a device, a device and a storage medium for characterizing ultrasonic radiation force and sound field are proposed.

[0005] In a first aspect, a method for characterizing ultrasonic radiation force and sound field is provided. The method includes:

[0006] Obtain an adjustment signal;

[0007] In response to the adjustment signal, adjust the relative phase of a pair of interdigital transducers to control the movement of the microparticle, and obtain the motion data of the microparticle in the microchannel, where the motion data includes the velocity, acceleration, and motion time of the microparticle, and the microparticle is captured in the standing wave sound field of the surface acoustic wave generated by the interdigital transducer;

[0008] Calculate a correction factor according to the state of the microparticle in the microchannel, the radius of the microparticle, and the distance between the microparticle and the piezoelectric substrate of the interdigital transducer;

[0009] Based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor of the microparticle, calculate the ultrasonic radiation force exerted on the microparticle in the microchannel;

[0010] Based on the calculation of the ultrasonic radiation force, obtain the sound pressure in the microchannel.

[0011] In a second aspect, a device for characterizing ultrasonic radiation force and sound field is provided. The device includes:

[0012] An obtaining module, configured to obtain an adjustment signal;

[0013] A response module, configured to adjust the relative phase of a pair of interdigital transducers in response to the adjustment signal to control the movement of microparticles, and obtain the motion data of the microparticles in the microchannel, where the motion data includes the velocity, acceleration, and motion time of the microparticles, and the microparticles are captured in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers;

[0014] A first calculation module, configured to calculate a correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers;

[0015] A second calculation module, configured to calculate the ultrasonic radiation force received by the microparticles in the microchannel based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor;

[0016] A third calculation module, configured to perform calculations based on the ultrasonic radiation force to obtain the sound pressure in the microchannel.

[0017] In a third aspect, a computer device is provided, including a memory, a processor, and a computer program stored in the memory and executable on the processor. When the processor executes the computer program, the steps of the above ultrasonic radiation force and sound field characterization method are implemented.

[0018] In a fourth aspect, a computer-readable storage medium is provided. The computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the steps of the above ultrasonic radiation force and sound field characterization method are implemented.

[0019] The ultrasonic radiation force and sound field characterization method proposed by the present invention obtains an adjustment signal, then adjusts the relative phase of a pair of interdigital transducers in response to the adjustment signal to control the movement of microparticles, and obtains the motion data of the microparticles in the microchannel, where the motion data includes the velocity, acceleration, and motion time of the microparticles, and the microparticles are captured in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers. Then, a correction factor is calculated according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers. Furthermore, the ultrasonic radiation force received by the microparticles in the microchannel is calculated based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor. Finally, calculations are performed based on the ultrasonic radiation force to obtain the sound pressure in the microchannel, and the ultrasonic radiation force received by the microparticles and the sound field in the microchannel can be characterized by the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor. Description of the Drawings

[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0021] Among them:

[0022] Figure 1 It is an application environment diagram of the ultrasonic radiation force and sound field characterization method in an embodiment;

[0023] Figure 2 It is a flowchart of the ultrasonic radiation force and sound field characterization method in an embodiment;

[0024] Figure 3 It is a particle manipulation experiment diagram of the ultrasonic radiation force and sound field characterization method in an embodiment;

[0025] Figure 4 It is a force analysis diagram of the particles in the ultrasonic radiation force and sound field characterization method in an embodiment;

[0026] Figure 5 It is a structural block diagram of the ultrasonic radiation force and sound field characterization device in an embodiment;

[0027] Figure 6 It is a structural block diagram of a computer device in an embodiment;

[0028] Figure 7 It is a structural block diagram of a computer device in another embodiment. Specific embodiments

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the technical field to which this application belongs; the terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" and any variations thereof in the specification and claims of this application and the above drawings are intended to cover non-exclusive inclusion. The terms "first", "second", etc. in the specification and claims of this application or the above drawings are used to distinguish different objects and are not used to describe a specific order.

[0030] Reference to "embodiment" in this document means that the specific features, structures, or characteristics described in connection with the embodiment can be included in at least one embodiment of the present application. The phrase appears in various places in the specification and does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0031] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0032] The method for characterizing ultrasonic radiation force and sound field provided by the embodiments of the present invention can be applied in an application environment such as Figure 1 where the client 110 communicates with the server 120 through a network. The server 120 can receive an adjustment signal through the client 110, and then, in response to the adjustment signal, adjust the relative phase of a pair of interdigital transducers to control the movement of microparticles and obtain the motion data of the microparticles in the microchannel. The motion data includes the velocity, acceleration, and motion time of the microparticles. The microparticles are captured in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers. Then, according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers, a correction factor is calculated. Furthermore, based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor of the microparticles, the ultrasonic radiation force received by the microparticles in the microchannel is calculated. Finally, based on the calculation of the ultrasonic radiation force, the sound pressure in the microchannel is obtained, and the ultrasonic radiation force received by the microparticles and the sound field in the microchannel can be characterized through the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor. Among them, the client 110 can be, but is not limited to, various personal computers, laptop computers, smartphones, tablet computers, and portable wearable devices. The server 120 can be implemented by an independent server or a server cluster composed of multiple servers. The present invention will be described in detail below through specific embodiments.

[0033] Please refer to Figure 2 as shown in Figure 2 which is a flowchart of a method for characterizing ultrasonic radiation force and sound field provided by an embodiment of the present invention, including the following steps:

[0034] Step S101: Obtain an adjustment signal;

[0035] For example, adjustment operation buttons are displayed on the display screen of a computer device. In response to a click operation by the user on the adjustment operation buttons, an adjustment instruction is triggered, and then, based on the adjustment instruction, the adjustment signal is generated.

[0036] Step S102: In response to the adjustment signal, adjust the relative phase of a pair of interdigital transducers to control the movement of the microparticles, and obtain the motion data of the microparticles in the microchannel, where the motion data includes the velocity, acceleration, and motion time of the microparticles, and the microparticles are captured in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers;

[0037] Among them, the microchannel can be a polydimethylsiloxane (PDMS) channel, and the microparticles can be polystyrene microspheres. It should be noted that when the polystyrene microspheres are in the standing wave sound field of the surface acoustic wave generated by a pair of interdigital transducers, the microspheres will be captured at the position of the standing wave node. Changing the relative phase of a pair of interdigital transducers can change the position of the standing wave node, thereby controlling the quantitative movement of the polystyrene microspheres captured at the position of the standing wave node. As Figure 3 shown in the particle manipulation experimental diagram, change the relative phase of a pair of interdigital transducers to control the quantitative movement of the polystyrene microspheres at the position of the standing wave node.

[0038] It should also be noted that surface acoustic wave: The surface acoustic wave is also called Rayleigh wave, which is a kind of ultrasonic wave propagating along the surface of an object, usually generated by an interdigital transducer. The interdigital transducer is formed by plating interdigital electrodes on a piezoelectric substrate. When a sinusoidal wave signal with a corresponding frequency is input, a surface wave signal with a corresponding frequency will be generated. It has the characteristics of high frequency, miniaturization, and low energy loss.

[0039] For example, during the movement of the microspheres, the displacement information of the microspheres is obtained through the cross-correlation algorithm, and the time interval Δt between two adjacent images is fixed, so as to obtain the movement speed of the microspheres. By performing cross-correlation calculations on all adjacent images during the manipulation of the microspheres, the trajectory of the microparticle movement and the speed of movement at each moment are obtained.

[0040] Step S103: Calculate a correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducer;

[0041] In one embodiment, if the state of the microparticles in the microchannel is that the particles are suspended in the middle of the microchannel, then based on the radius of the microparticles and the distance between the microparticles and the piezoelectric substrate of the interdigital transducer, a correction factor is calculated.

[0042] The correction factor when the particles are suspended in the middle of the microchannel is represented by the following formula:

[0043]

[0044] Wherein, r refers to the radius of the particle, z refers to the distance between the particle and the piezoelectric substrate of the interdigital transducer, and χ2 refers to the correction factor.

[0045] In one embodiment, when the state of the particle in the microchannel is that the particle is not suspended in the middle of the microchannel, the correction factor is calculated based on the radius of the particle, the distance between the particle and the piezoelectric substrate of the interdigital transducer, and the channel width of the microchannel.

[0046] The correction factor is represented by the following formula:

[0047]

[0048] χ2 = χ1(z) + χ1(h - z) - 1

[0049] Wherein, χ2 refers to the correction factor, r refers to the radius of the particle, z refers to the distance between the particle and the piezoelectric substrate of the interdigital transducer, and h refers to the channel width of the microchannel.

[0050] Specifically, as Figure 4 shown in the force analysis diagram of the particle.

[0051] Step S104: Calculate the ultrasonic radiation force received by the particle in the microchannel based on the particle size, the velocity, the acceleration, the movement time, the fluid viscosity of the microchannel, and the correction factor;

[0052] In one embodiment, the ultrasonic radiation force is represented by the following formula:

[0053]

[0054] F d = 6πμR c vχ2

[0055]

[0056] Wherein, F rad represents the ultrasonic radiation force received by the particle, F d represents the viscous drag force, m represents the mass of the particle, v represents the movement speed of the particle, t represents the movement time of the particle, μ represents the fluid viscosity of the fluid in the microchannel, R c represents the particle size, and χ2 represents the correction factor.

[0057] Step S105: Calculate based on the ultrasonic radiation force to obtain the sound pressure in the microchannel.

[0058] The sound pressure in the microchannel is as follows:

[0059]

[0060]

[0061]

[0062] where F rad represents the ultrasonic radiation force exerted on the particle, p a represents the sound pressure in the microchannel, k represents the wave number of the surface acoustic wave generated by the interdigital transducer, d represents the distance of the particle from the standing wave node, a represents the radius of the particle, ρ0 represents the density of the microchannel environment, c0 represents the sound speed of the microchannel environment, is the ratio of the particle density of the particle to the density of the fluid in the microchannel, is the ratio of the particle compression ratio to the liquid compression ratio.

[0063] The particle compression ratio and the liquid compression ratio can be calculated through the compression ratio formula. Among them, the compression ratio formula is as follows:

[0064] where c represents the sound speed and ρ represents the density.

[0065] The ultrasonic radiation force and sound field characterization method proposed in this embodiment obtains an adjustment signal, then adjusts the relative phase of a pair of interdigital transducers in response to the adjustment signal to control the movement of the particle, and obtains the motion data of the particle in the microchannel. Among them, the motion data includes the velocity, acceleration, and motion time of the particle. The particle is captured in the standing wave sound field of the surface acoustic wave generated by the interdigital transducer, and then a correction factor is calculated according to the state of the particle in the microchannel, the radius of the particle, and the distance between the particle and the piezoelectric substrate of the interdigital transducer. Furthermore, based on the particle size, the velocity, the acceleration, the motion time, the fluid viscosity of the microchannel, and the correction factor of the particle, the ultrasonic radiation force exerted on the particle in the microchannel is calculated. Finally, based on the calculation of the ultrasonic radiation force, the sound pressure in the microchannel is obtained, and the ultrasonic radiation force exerted on the particle and the sound field in the microchannel can be characterized through the particle size, the velocity, the acceleration, the motion time, the fluid viscosity of the microchannel, and the correction factor.

[0066] Please refer to Figure 5 shown. In one embodiment, an ultrasonic radiation force and sound field characterization device is provided. The device includes:

[0067] An acquisition module 10 for acquiring an adjustment signal;

[0068] A response module 20, configured to adjust the relative phase of a pair of interdigital transducers in response to the adjustment signal to control the movement of microparticles and obtain the motion data of the microparticles in the microchannel, wherein the motion data includes the velocity, acceleration, and motion time of the microparticles, and the microparticles are captured in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers;

[0069] A first calculation module 30, configured to calculate a correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers;

[0070] A second calculation module 40, configured to calculate the ultrasonic radiation force received by the microparticles in the microchannel based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor;

[0071] A third calculation module 50, configured to perform calculations based on the ultrasonic radiation force to obtain the sound pressure in the microchannel.

[0072] In one embodiment, the first calculation module 30 is further configured to: if the state of the microparticles in the microchannel is that the particles are suspended in the middle of the microchannel, calculate the correction factor based on the radius of the microparticles and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers.

[0073] The correction factor is represented by the following formula:

[0074]

[0075] where r refers to the radius of the microparticles, z refers to the distance between the microparticles and the piezoelectric substrate of the interdigital transducers, and χ2 refers to the correction factor.

[0076] In one embodiment, the first calculation module 30 is further configured to: if the state of the microparticles in the microchannel is that the particles are not suspended in the middle of the microchannel, calculate the correction factor based on the radius of the microparticles, the distance between the microparticles and the piezoelectric substrate of the interdigital transducers, and the channel width of the microchannel.

[0077] In one embodiment, the correction factor is represented by the following formula:

[0078]

[0079] χ2 = χ1(z) + χ1(h - z) - 1

[0080] Wherein, χ2 refers to the correction factor, r refers to the radius of the particle, z refers to the distance between the particle and the piezoelectric substrate of the interdigital transducer, and h refers to the channel width of the microchannel.

[0081] In one embodiment, the ultrasonic radiation force is expressed by the following formula:

[0082]

[0083] F d = 6πμR c vχ2

[0084]

[0085] Wherein, F rad represents the ultrasonic radiation force received by the particle, F d represents the viscous drag force, m represents the mass of the particle, v represents the moving speed of the particle, t represents the moving time of the particle, μ represents the fluid viscosity of the fluid in the microchannel, R c represents the particle size of the particle, and χ2 represents the correction factor.

[0086] In one embodiment, the sound pressure in the microchannel is shown by the following formula:

[0087]

[0088]

[0089]

[0090] Wherein, F rad代 represents the ultrasonic radiation force received by the particle, p a represents the sound pressure in the microchannel, k respectively represents the wave number of the surface acoustic wave generated by the interdigital transducer, d represents the distance of the particle from the standing wave node, a represents the radius of the particle, ρ0 represents the density of the microchannel environment, c0 represents the sound speed of the microchannel environment, is the ratio of the particle density of the particle to the density of the fluid in the microchannel, is the ratio of the particle compression ratio to the liquid compression ratio.

[0091] In one embodiment, a computer device is provided. The computer device can be a server, and its internal structure diagram can be as Figure 6As shown in the figure. The computer device includes a processor, a memory, a network interface, and a database connected through a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile and / or volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program, and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The network interface of the computer device is used to communicate with an external client through a network connection. When the computer program is executed by the processor, it realizes the functions or steps on the server side of an ultrasonic radiation force and sound field characterization method.

[0092] In one embodiment, a computer device is provided. The computer device can be a client, and its internal structure diagram can be as Figure 7 shown in the figure. The computer device includes a processor, a memory, a network interface, a display screen, and an input device connected through a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The network interface of the computer device is used to communicate with an external server through a network connection. When the computer program is executed by the processor, it realizes the functions or steps on the client side of an ultrasonic radiation force and sound field characterization method.

[0093] In one embodiment, a computer device is proposed, including a memory, a processor, and a computer program stored in the memory and executable on the processor. When the processor executes the computer program, the following steps are realized:

[0094] Obtain an adjustment signal;

[0095] In response to the adjustment signal, adjust the relative phase of a pair of interdigital transducers to control the movement of the microparticles, and obtain the motion data of the microparticles in the microchannel. The motion data includes the velocity, acceleration, and motion time of the microparticles, and the microparticles are captured in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers;

[0096] Calculate a correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers;

[0097] Based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor of the microparticles, calculate the ultrasonic radiation force received by the microparticles in the microchannel;

[0098] Based on the calculation of the ultrasonic radiation force, the sound pressure in the microchannel is obtained.

[0099] The ultrasonic radiation force and sound field characterization method proposed in this embodiment obtains an adjustment signal, then adjusts the relative phase of a pair of interdigital transducers in response to the adjustment signal to control the movement of microparticles, and obtains the motion data of the microparticles in the microchannel, where the motion data includes the velocity, acceleration, and motion time of the microparticles. The microparticles are trapped in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers. Then, according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers, a correction factor is calculated. Furthermore, based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor, the ultrasonic radiation force received by the microparticles in the microchannel is calculated. Finally, based on the calculation of the ultrasonic radiation force, the sound pressure in the microchannel is obtained, and it is possible to characterize the ultrasonic radiation force received by the microparticles and the sound field in the microchannel through the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor.

[0100] In one embodiment, a computer-readable storage medium is proposed. The computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the following steps are implemented:

[0101] Obtain an adjustment signal;

[0102] In response to the adjustment signal, adjust the relative phase of a pair of interdigital transducers to control the movement of microparticles, and obtain the motion data of the microparticles in the microchannel, where the motion data includes the velocity, acceleration, and motion time of the microparticles. The microparticles are trapped in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers;

[0103] Calculate a correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers;

[0104] Based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor, calculate the ultrasonic radiation force received by the microparticles in the microchannel;

[0105] Based on the calculation of the ultrasonic radiation force, obtain the sound pressure in the microchannel.

[0106] The method for characterizing ultrasonic radiation force and sound field proposed in this embodiment obtains an adjustment signal, and then, in response to the adjustment signal, adjusts the relative phase of a pair of interdigital transducers to control the movement of microparticles, and obtains the motion data of the microparticles in the microchannel. The motion data includes the velocity, acceleration, and motion time of the microparticles. The microparticles are trapped in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers. Then, according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers, a correction factor is calculated. Furthermore, based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor of the microparticles, the ultrasonic radiation force received by the microparticles in the microchannel is calculated. Finally, based on the calculation of the ultrasonic radiation force, the sound pressure in the microchannel is obtained, and it is possible to characterize the ultrasonic radiation force received by the microparticles and the sound field in the microchannel through the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor.

[0107] It should be noted that for the functions or steps that can be realized by the above computer-readable storage medium or computer device, reference can be made to the relevant descriptions on the server side and the client side in the foregoing method embodiments. To avoid repetition, they will not be described in detail here.

[0108] Those of ordinary skill in the art can understand that all or part of the processes of implementing the methods in the above embodiments can be completed by instructing relevant hardware through a computer program. The computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the above method embodiments. Among them, any reference to a memory, storage, database, or other medium used in the embodiments provided in the present application can include non-volatile and / or volatile memories. Non-volatile memories can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memories can include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in various forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

[0109] Those skilled in the art can clearly understand that, for the convenience and conciseness of description, only the above division of each functional unit and module is used as an example. In actual applications, the above functions can be allocated to different functional units and modules according to needs, that is, the internal structure of the device is divided into different functional units or modules to complete all or part of the functions described above.

[0110] The above-described embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention, and should all be included in the protection scope of the present invention.

Claims

1. An ultrasonic radiation force and sound field characterization method, characterized in that, The ultrasonic radiation force and sound field characterization method includes: Obtaining an adjustment signal; In response to the adjustment signal, adjusting the relative phase of a pair of interdigital transducers to control the movement of microparticles, and obtaining the motion data of the microparticles in the microchannel, where the motion data includes the velocity, acceleration, and motion time of the microparticles, and the microparticles are trapped in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers; Calculating a correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers; Calculating the ultrasonic radiation force received by the microparticles in the microchannel based on the particle size, velocity, acceleration, motion time, fluid viscosity of the microchannel, and the correction factor; Calculating the sound pressure in the microchannel based on the ultrasonic radiation force.

2. The ultrasonic radiation force and sound field characterization method according to claim 1, characterized in that, The step of calculating the correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers includes: If the state of the microparticles in the microchannel is that the particles are suspended in the middle of the microchannel, then calculating the correction factor based on the radius of the microparticles and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers.

3. The ultrasonic radiation force and sound field characterization method according to claim 2, characterized in that, The correction factor is represented by the following formula: where r refers to the radius of the microparticles, z refers to the distance between the microparticles and the piezoelectric substrate of the interdigital transducers, and χ2 refers to the correction factor.

4. The ultrasonic radiation force and sound field characterization method according to claim 1, characterized in that, The step of calculating the correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers further includes: If the state of the microparticles in the microchannel is that the particles are not suspended in the middle of the microchannel, then calculating the correction factor based on the radius of the microparticles, the distance between the microparticles and the piezoelectric substrate of the interdigital transducers, and the channel width of the microchannel.

5. The ultrasonic radiation force and sound field characterization method according to claim 4, characterized in that, The correction factor is represented by the following formula: χ2 = χ1(z) + χ1(h - z) - 1 where χ2 refers to the correction factor, r refers to the radius of the microparticles, z refers to the distance between the microparticles and the piezoelectric substrate of the interdigital transducers, and h refers to the channel width of the microchannel.

6. The ultrasonic radiation force and sound field characterization method according to claim 1, characterized in that, The ultrasonic radiation force is represented by the following formula: F d = 6πμR c vχ2 Among them, F rad represents the ultrasonic radiation force on the particle, F d represents the viscous drag force, m represents the mass of the particle, v represents the moving speed of the particle, t represents the moving time of the particle, μ represents the fluid viscosity of the fluid in the microchannel, R c represents the particle size of the particle, and χ2 represents the correction factor.

7. The ultrasonic radiation force and sound field characterization method according to claim 1, characterized in that, The sound pressure in the microchannel is as shown in the following formula: Among them, F rad represents the ultrasonic radiation force received by the microparticle, p a represents the acoustic pressure in the microchannel, k represents the acoustic wave number of the surface acoustic wave generated by the interdigital transducer respectively, d represents the distance of the microparticle from the standing wave node, a represents the radius of the microparticle, ρ0 represents the density of the microchannel environment, c0 represents the sound speed of the microchannel environment, is the ratio of the particle density of the microparticle to the density of the fluid in the microchannel, is the ratio of the particle compression ratio to the liquid compression ratio.

8. An ultrasonic radiation force and sound field characterization device, characterized in that, The ultrasonic radiation force and sound field characterization device includes: An acquisition module for acquiring an adjustment signal; A response module for adjusting the relative phase of a pair of interdigital transducers in response to the adjustment signal to control the movement of microparticles and acquiring the motion data of the microparticles in the microchannel, where the motion data includes the velocity, acceleration, and motion time of the microparticles, and the microparticles are trapped in the standing wave sound field of the surface acoustic wave generated by the interdigital transducers; A first calculation module for calculating a correction factor according to the state of the microparticles in the microchannel, the radius of the microparticles, and the distance between the microparticles and the piezoelectric substrate of the interdigital transducers; A second calculation module, configured to calculate the ultrasonic radiation force exerted on the particle in the microchannel based on the particle size, the velocity, the acceleration, the movement time, the fluid viscosity of the microchannel, and the correction factor; A third calculation module, configured to calculate the sound pressure in the microchannel based on the ultrasonic radiation force.

9. A computer device, comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, characterized in that, When the processor executes the computer program, the steps of the ultrasonic radiation force and sound field characterization method according to any one of claims 1 to 7 are implemented.

10. A computer-readable storage medium storing a computer program, characterized in that, When the computer program is executed by the processor, the steps of the ultrasonic radiation force and sound field characterization method according to any one of claims 1 to 7 are implemented.

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