Medical infusion device system with extended dosing range

Abstract

The present invention relates to a medical infusion device system comprising: a first dosing chamber for delivering at least a first minimum dose of a liquid medicament; a second dosing chamber for delivering at least a second minimum dose of the liquid medicament; a fluid line operatively coupled to the first dosing chamber and the second dosing chamber for delivering a total amount of liquid medicament delivered by the first dosing chamber and the second dosing chamber to an outlet of the fluid line; and a controller for controlling the total amount of the liquid medicament. To provide relatively small and large doses both quickly and accurately, the second minimum dose of the liquid drug provided by the second dosing chamber is greater than the first minimum dose of the liquid drug provided by the first dosing chamber.

Description

[0001] The present invention relates to a medical infusion device system, which includes: a first dosing chamber configured to deliver a first minimum dose of a liquid drug in one or more multiples; a second dosing chamber configured to deliver a second minimum dose of the liquid drug in one or more multiples; a fluid line operatively coupled to the first dosing chamber and the second dosing chamber for delivering the total amount of the liquid drug delivered by the first dosing chamber and the second dosing chamber to an outlet of the fluid line; and a controller configured to control the total amount of the liquid drug to be delivered via the fluid line by operating the first dosing chamber and the second dosing chamber.

[0002] Medical infusion device systems known heretofore have been used to administer liquid drugs to a user. The liquid drugs are intended to improve the health condition of a patient. During use, the liquid drugs are dispensed by a first dosing chamber and a second dosing chamber. Thus, together, at least a first minimum dose provided by the first dosing chamber and at least a second minimum dose provided by the second dosing chamber constitute the total amount of the liquid drug. The operation of the first dosing chamber and the operation of the second dosing chamber are controlled by a controller. The first dosing chamber and the second dosing chamber are operated with the same type of liquid drug.

[0003] However, when there are two dosing chambers contributing to the total amount of the liquid drug to be delivered to a patient, the overall dosing accuracy of medical infusion systems known heretofore is based on the dosing accuracy of the first dosing chamber and the dosing accuracy of the second dosing chamber. It must be noted that the total dose administered does not result in an overdose or underdose of the liquid drug. In particular, when delivering a small amount of liquid drug, the deviation in the amount of the liquid drug delivered is significant for the total dose administered. For example, due to individual needs and metabolic characteristics, different users of medical infusion device systems known heretofore may have different requirements in terms of dosage. Infants generally require a lower dose of liquid drug than adults, and when using a medical infusion system used by both infants and adults, infants generally bear a higher risk of overdose. Such known medical infusion systems will exhibit an overall dosing accuracy that is a compromise between low-weight patients who require a higher dosing accuracy for smaller doses and large-weight patients who require a lower dosing accuracy for larger doses. In a medical infusion system with two chambers, the overall dosing accuracy is based on the dosing accuracy of the first dosing chamber and the dosing accuracy of the second dosing chamber.

[0004] Therefore, an object of the present invention is to provide a medical infusion device system that avoids at least one of the problems associated with medical infusion device systems known in the prior art. In particular, an object of the present invention is to provide a medical infusion device system that enables more variable dosing of a liquid drug.

[0005] At least one of the above objectives is solved by providing the subject matter described in the claims and throughout the specification.

[0006] According to a first aspect, a medical infusion device system is provided. The medical infusion device system includes: a first drug delivery chamber configured to deliver one or more of a first minimum drug delivery amount of a liquid drug; a second drug delivery chamber configured to deliver one or more of a second minimum drug delivery amount of the liquid drug; a fluid line operatively coupled to the first drug delivery chamber and the second drug delivery chamber for delivering a total amount of the liquid drug delivered by the first drug delivery chamber and the second drug delivery chamber to an outlet of the fluid line; and a controller configured to control the operation of the first drug delivery chamber and the second drug delivery chamber to provide the total amount of the liquid drug via the fluid line, wherein the second minimum drug delivery amount of the liquid drug provided by the second drug delivery chamber is greater than the first minimum drug delivery amount of the liquid drug provided by the first drug delivery chamber.

[0007] The first minimum drug delivery amount and the second minimum drug delivery amount are inherent parameters of the first drug delivery chamber and the second drug delivery chamber, respectively. The first minimum drug delivery amount and the second minimum drug delivery amount are determined by the infrastructure, mechanisms, and electronics of the first drug delivery chamber and the second drug delivery chamber, respectively, and any additional components of the medical infusion device system required to deliver a liquid drug dose by operating the first drug delivery chamber and the second drug delivery chamber, respectively. For example, the respective minimum drug delivery amounts of the first drug delivery chamber and the second drug delivery chamber are equal to the minimum volumes delivered from the first drug delivery chamber or the second drug delivery chamber, respectively, into the ambient air, i.e., there is no other pressure hindering the flow leaving the outlets of the first drug delivery chamber or the second drug delivery chamber, compared to the pressure of the ambient air. The first minimum drug delivery amount and the second minimum drug delivery amount cannot be further reduced by operating the first drug delivery chamber and the second drug delivery chamber individually, i.e., the first minimum drug delivery amount and the second minimum drug delivery amount are the respective minimum amounts that can be repeatedly delivered by operating the first drug delivery chamber and the second drug delivery chamber, respectively, with a standard deviation of ±5% under the settings of the medical infusion device. The first minimum drug delivery amount is the minimum possible volume that can be delivered by operating the first drug delivery chamber. Similarly, the second minimum drug delivery amount is the minimum possible volume that can be delivered by operating the second drug delivery chamber.

[0008] However, since the first minimum dosage and the second minimum dosage are used together to constitute the total amount of the liquid drug delivered through the outlet of the fluid line of the medical infusion device system, the first minimum dosage and the second minimum dosage can be used to vary the total amount of the liquid drug, which can then be delivered via the fluid line. The first minimum dosage can be added to the second minimum dosage and vice versa. That is, the second minimum dosage can also be added to the first minimum dosage. Therefore, a larger amount of only one or more of the second minimum dosage or only one or more of the first minimum dosage can be administered separately, so that the total dosage can be extended by using both the first dosing chamber and the second dosing chamber. In particular, by dividing the total amount of the liquid drug to be administered into multiple amounts of the first minimum dosage and the second minimum dosage, the respective accuracies of the first dosing chamber and the second dosing chamber can be utilized to provide the total amount of the liquid drug with high accuracy.

[0009] The first minimum dosage and the second minimum dosage have different volumes, where the second minimum dosage is greater than the first minimum dosage, i.e., the first dosage is less than the second minimum dosage. Therefore, a relatively large volume can be delivered to the user of the medical infusion device system by delivering one or more multiples of the second minimum dosage. Delivering one or more multiples of the second minimum dosage to provide the relatively large volume is faster than delivering the relatively large volume by delivering the first dosage at a correspondingly higher multiple.

[0010] Controlling the operation of the first dosing chamber and the second dosing chamber can deliver the total volume by: providing a relatively large volume by actuating the second dosing chamber, and providing a relatively small volume by actuating the first dosing chamber. Therefore, by delivering volumes from both the first dosing chamber and the second dosing chamber simultaneously, the total volume delivered can be advantageously increased beyond the maximum volume that can be delivered by the second dosing chamber. In the context of the present invention, the controller is an electronic component configured to control the actuation of the first dosing chamber and the second dosing chamber. For example, the controller can be a microprocessor. "Operatively coupled" means the configuration of the medical device system in which the fluid line is in fluid communication with the first dosing chamber and the second dosing chamber such that the liquid drug from the first dosing chamber and / or the second dosing chamber can flow out of the respective dosing chambers through the outlet.

[0011] According to an embodiment of the present invention, the outlet of the fluid line can be formed by or operatively coupled to an intubation or infusion device. The coupling can be irreversible or reversible, preferably reversible. The intubation can be a steel intubation or a soft intubation, preferably a soft intubation.

[0012] According to an embodiment of the present invention, the medical infusion device system may include an infusion pump having a first drug delivery chamber, a second drug delivery chamber, a fluid line, and a controller. The controller may be located inside the infusion pump, or the controller may be a separate device, such as a remote control communicatively connected to the infusion pump. The remote control may be a mobile device or a personal computer. The infusion pump may be a patch pump, i.e., a body-wearable pump, which includes an adhesive layer for temporarily adhering the body-wearable pump to the patient's body.

[0013] The liquid drug may be any kind of insoluble drug. In particular, the liquid drug may be insulin or glucagon.

[0014] According to one embodiment, the controller is configured to operate the first drug delivery chamber and the second drug delivery chamber simultaneously for transferring the liquid drug to the second drug delivery chamber in an amount equal to one or more of the first minimum drug delivery amounts and / or for transferring the liquid drug to the first drug delivery chamber in an amount equal to one or more of the second minimum drug delivery amounts.

[0015] The controller can not only control the operations of the first dosing chamber and the second dosing chamber to deliver a liquid medicament through the outlet of the fluid line, but also control the simultaneous operations of the first dosing chamber and the second dosing chamber to transfer the liquid medicament from one of the first dosing chamber or the second dosing chamber to the corresponding other one of the first dosing chamber or the second dosing chamber. For example, one or more times the minimum first dosing amount can be transferred from the first dosing chamber to the second dosing chamber and vice versa. In addition, one or more times the minimum second dosing amount can be transferred from the first dosing chamber to the second dosing chamber and vice versa. Thus, the controller can be advantageously used to balance the filling liquid levels in the first dosing chamber and the second dosing chamber. The transfer of liquid to the first dosing chamber can be advantageous in cases where, for certain patients, such as patients with low body weight, such as children, a very small amount of liquid medicament is typically to be delivered and the small amount is below the minimum dosing amount that can be delivered by the second dosing chamber. Thus, replenishment of the first dosing chamber increases the total volume of the liquid medicament, which can be delivered by the first dosing chamber in an amount less than the minimum dosing amount of the second dosing chamber but greater than the total volume of the first dosing chamber. For example, in the case where a relatively large amount of liquid medicament is to be delivered through the outlet of the fluid line, during an idle phase, the liquid medicament can first be transferred from the first dosing chamber to the second dosing chamber. Secondly, once the liquid medicament has been transferred from the first dosing chamber to the second dosing chamber, a relatively large amount can be delivered only by controlling the operation of the second dosing chamber via the outlet of the fluid line. Thus, the delivery speeds of the first dosing chamber and the second dosing chamber can be utilized more beneficially than: providing a relatively large amount of liquid medicament by controlling the operation of the first dosing chamber, which may take longer than when using the second dosing chamber.

[0016] According to an embodiment of the present invention, the controller is configured to control the simultaneous operations of the first dosing chamber and the second dosing chamber for delivering a total amount of the liquid medicament via the fluid line and through the outlet, wherein the total amount of the liquid medicament is equal to the sum or difference of one or more times the first minimum dosing amount of the liquid medicament and one or more times the second minimum dosing amount of the liquid medicament, and wherein the total amount of the liquid medicament delivered to the outlet is equal to or greater than zero.

[0017] By operating the first drug delivery chamber and the second drug delivery chamber simultaneously, at least the first drug dose or a multiple thereof can be transferred into the second drug delivery chamber, or at least the second drug dose or a multiple thereof can be transferred into the first drug delivery chamber. Thus, the first minimum drug dose or a multiple thereof can be subtracted from the second minimum drug dose, and vice versa. That is, the second minimum drug dose or a multiple thereof can be subtracted from the first minimum drug dose. The total amount of liquid drug provided by controlling the first drug delivery chamber and the second drug delivery chamber can be the sum of the first minimum drug dose or a multiple thereof and the second minimum drug dose or a multiple thereof; or the total amount of liquid drug provided by operating the first drug delivery chamber and the second drug delivery chamber simultaneously can be the difference between one or more multiples of the first minimum drug dose and one or more multiples of the second minimum drug dose. However, in the case of subtraction, the total amount of liquid drug should not be a negative amount, which may cause the liquid drug and / or body fluid to be withdrawn from the patient into the outlet. For the transfer of liquid drug from the first drug delivery chamber to the second drug delivery chamber, or vice versa, the dosing accuracy has no effect on the dosing provided by the medical infusion device system. However, the transfer of liquid drug from one drug delivery chamber to another helps the user to adapt the configuration of the medical infusion device system to the user's individual needs. For example, a user who frequently administers a small amount of liquid drug will likely have a higher need to replenish the first drug delivery chamber.

[0018] Accordingly, in one embodiment, the controller is configured to control the operation of the first drug delivery chamber and the second drug delivery chamber for providing the total amount of the liquid drug via the fluid line, wherein the total amount of the liquid drug is equal to or greater than zero. This safety mechanism is associated with the advantage of preventing liquid from entering the outlet or the fluid line. In one embodiment, the medical infusion device system includes a sensor configured to detect negative pressure in the outlet, wherein the sensor is operatively connected to the controller to prevent the liquid drug from flowing through the outlet into the first drug delivery chamber and / or the second drug delivery chamber. Additionally or alternatively, the medical infusion device system may include a check valve that prevents the liquid drug from flowing through the outlet into the first drug delivery chamber and / or the second drug delivery chamber.

[0019] According to one embodiment of the present invention, the first dosing chamber is operatively coupled to a first drive mechanism for actuating the first dosing chamber, and wherein the second dosing chamber is operatively coupled to a second drive mechanism for actuating the second dosing chamber, and wherein the controller is configured to control the operation of the first drive mechanism and the second drive mechanism. The operation of the first drive mechanism can be controlled by the controller to dispense liquid medicament from the first dosing chamber or to allow liquid medicament to enter the first dosing chamber. Similarly, the operation of the second drive mechanism can be controlled by the controller to dispense liquid medicament from the second dosing chamber or to allow liquid medicament to enter the second dosing chamber. Thus, since the first drive mechanism is operatively coupled to the first dosing chamber and the second drive mechanism is operatively coupled to the second dosing chamber, controlling the operation of the first drive mechanism and the second drive mechanism also controls the operation of the first dosing chamber and the second dosing chamber, and thus controls the total amount of liquid medicament flowing through the fluid line. In this context, "operatively coupled" means that the drive mechanism is configured to effect, respectively, the discharge or filling of liquid medicament from or into the corresponding dosing chamber.

[0020] According to one embodiment of the present invention, the first dosing chamber is a first reservoir configured to contain the liquid medicament, wherein the first dosing chamber includes a first plunger movably disposed within the first reservoir for delivering the first minimum dose of the liquid medicament one or more times when actuated by the first drive mechanism, and the second dosing chamber is a second reservoir configured to contain the liquid medicament, wherein the second dosing chamber includes a second plunger movably disposed within the second reservoir for delivering the second minimum dose of the liquid medicament one or more times when actuated by the second drive mechanism.

[0021] The first drive mechanism moves the first plunger within the first reservoir. The first reservoir forms the first dosing chamber. By advancing the first plunger within the first reservoir in a first direction, liquid medicament is dispensed from the first reservoir. When the first plunger is moved by the first drive mechanism in a second direction opposite to the first direction, liquid medicament is aspirated into the first reservoir. Similarly, the second drive mechanism moves the second plunger within the second reservoir. The second reservoir forms the second dosing chamber. When advancing in a third direction within the second reservoir, liquid medicament is dispensed from the second reservoir. When the second plunger is moved within the second reservoir in a fourth direction opposite to the third direction, liquid medicament is aspirated into the second reservoir. Thus, the first plunger is configured to move one or more times the first minimum dose, and the second plunger is configured to move one or more times the second minimum dose.

[0022] According to one embodiment of the present invention, the first reservoir has a first cross-section, and the second reservoir has a second cross-section different from the first cross-section. For example, the second cross-section of the second reservoir may be larger than the first cross-section of the first reservoir. By having cross-sections of different sizes, the delivery volume provided when the first plunger is moved a unit distance within the first reservoir is less than the delivery volume provided by moving the second plunger approximately the same distance within the second reservoir. "Cross-section" refers to the area of the plunger in contact with the liquid drug during use of the medical infusion device system.

[0023] According to one embodiment of the present invention, the second minimum dose is equal to an integer multiple of the first minimum dose. Since the second minimum dose is greater than the first minimum dose, the first minimum dose is equal to or less than half of the second minimum dose. For example, the second minimum dose may be equal to x times the first minimum dose, where x is an integer equal to 2, 3, 4, 5, 6, 7, 8, 9, or 10. Thus, the total amount of the liquid drug may be one or more times the second minimum dose plus or minus one or more times the first minimum dose. Thus, both large and small amounts of the liquid drug can be delivered by the medical infusion device system relatively quickly and with high accuracy compared to: a medical infusion device system having only one dosing chamber or two dosing chambers capable of delivering the same minimum dose. For example, the first minimum dose may be 0.01 ml, 0.001 ml, 0.0001 ml, 0.00001 ml, or 0.000001 ml.

[0024] At least one of the above objects is also solved by a method for operating a medical infusion device system according to one or more of the foregoing embodiments, wherein the method includes controlling, by the controller, the operation of the first dosing chamber and the second dosing chamber for providing the total amount of the liquid drug via the fluid line, wherein the total amount of the liquid drug is equal to or greater than zero, and the total amount of the liquid drug is equal to one or more times the first minimum dose plus or minus one or more times the second minimum dose.

[0025] Further advantages, features, and technical effects of the present invention will become apparent from the following description of the embodiments and the drawings.

[0026] Figure 1 A schematic diagram of a medical infusion device system according to an embodiment of the present invention is shown; and Figure 2a Shows according to Figure 1 a first operating mode of the medical infusion device system, Figure 2b Shows according to Figure 1 a second operating mode of the medical infusion device system,Figure 2c shows the third operating mode of a medical infusion device system according to Figure 1 and

[0027] Figure 2d shows the fourth operating mode of a medical infusion device system according to Figure 1 .

[0028] Figure 1 shows a schematic view of a medical infusion device system 1 according to an embodiment of the present invention. The medical infusion device system 1 includes a first drug delivery chamber 1 and a second drug delivery chamber 2. The first drug delivery chamber 2 forms a first reservoir configured to hold a liquid drug. A first plunger 2b is movable within the reservoir, wherein the movement of the first plunger 2b is caused by a first drive mechanism 2a. A fluid line 4 is operatively coupled to the first drug delivery chamber 2. Thus, when moved forward in a first direction, the liquid drug is dispensed from the first reservoir into the fluid line 4. When moved in a direction opposite to the first direction, the liquid drug is drawn into the first drug delivery chamber 2.

[0029] The fluid line 4 is further operatively coupled to a second drug delivery chamber 3. The second drug delivery chamber 3 forms a second reservoir that is also configured to hold the same amount of liquid drug as contained in the first drug delivery chamber 2. A second plunger 3b is movably disposed within the second drug delivery chamber 3, wherein the movement of the second plunger 3b is caused by a second drive mechanism 3a. Similar to the movement of the first plunger 2b, by moving the second plunger 3b in a second direction, the liquid drug contained in the second drug delivery chamber 3 is pushed into the fluid line 4, and when the second plunger 3b is moved in a direction opposite to the second direction, the liquid drug is allowed to enter the second drug delivery chamber 3.

[0030] The operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by a controller 6. The controller 6 is configured to control the operation of the first drug delivery chamber 2 and the second drug delivery chamber 3 to provide a total amount of liquid drug via the fluid line 4. The fluid line 4 includes an outlet 5. Here, the outlet 5 is coupled to an intubation tube.

[0031] The first dosing chamber 2 is configured to deliver one or more first minimum doses of a liquid medicament. Similarly, the second dosing chamber 3 is configured to deliver one or more of a second minimum dose of the liquid medicament, wherein the second minimum dose of the liquid medicament provided by the second dosing chamber 3 is greater than the first minimum dose of the liquid medicament provided by the first dosing chamber 2. The total amount of the liquid medicament is formed by adding or subtracting one or more first minimum doses and one or more second doses. Here, the cross-section of the first dosing chamber 2 is smaller than the cross-section of the second dosing chamber 3. Thus, the amount of liquid provided by the first dosing chamber 2 when the first plunger 2b is moved by a certain distance is less than the amount of liquid provided by the second dosing chamber 3 when the second plunger 3b is moved by approximately the same distance. In Figure 1 c

[0032] Figures 2a to 2d illustrates four exemplary operating modes of the medical infusion device system 1 according to Figure 1 an embodiment. The controller 6 is configured to control the operation of the first dosing chamber 2 and the second dosing chamber 3 and is thus configured to control the total amount of the liquid medicament delivered via the fluid line 4 and the outlet 5 of the fluid line 4.

[0033] The first operating mode is schematically illustrated in Figure 2a . According to the first operating mode, the operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by the controller 6 such that the first plunger 2b and the second plunger 3b are further advanced within the first dosing chamber 2 and the second dosing chamber 3, respectively. Thus, the liquid medicament is dispensed from the first dosing chamber 2 and the second dosing chamber 3 into the fluid line 4. Thus, at least the first minimum dose provided by the first dosing chamber 2 and at least the second minimum dose provided by the second dosing chamber 3 are added to reach the total amount of the liquid volume. In Figure 2a the flow of the liquid medicament and the corresponding movement of the first plunger 2b and the second plunger 3b are indicated by arrows.

[0034] The second operating mode is schematically illustrated in Figure 2b . According to the second operating mode, the operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by the controller 6 such that the first plunger 2b retracts within the first reservoir formed by the first dosing chamber 2 while the second plunger 3b is further advanced within the second reservoir formed by the second dosing chamber 3. However, one or more first minimum doses aspirated into the first dosing chamber 2 by retracting the first plunger 2b within the first dosing chamber 2 are less than one or more second minimum doses provided by further advancing the second plunger 3b within the second dosing chamber 3. Thus, the resulting total liquid volume is dispensed through the fluid line 4 and the outlet 5. Similarly, in Figure 2bIn it, the flow of the liquid drug and the corresponding movement of the first plunger 2b and the second plunger 3b are indicated by arrows. A part of the liquid amount dispensed from the second dosing chamber 3 is transferred into the first dosing chamber 2, while the remaining part of the liquid amount dispensed from the second dosing chamber 3 is delivered through the outlet 5 of the fluid line 4. The total amount provided through the outlet 5 is equal to the amount of the liquid drug provided by the second dosing chamber 3 minus the amount of the liquid drug aspirated into the first dosing chamber 2.

[0035] Figure 2c Schematically shows the third operating mode of the medical infusion device system 1 according to Figure 1 According to the third operating mode, the operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by the controller 6. The first drive mechanism 2a and the second drive mechanism 3a are operated so as to simultaneously move the first plunger 2b within the first dosing chamber 2 and the second plunger 3b within the second dosing chamber 3. Under the control of the controller 6, the first drive mechanism 2a retracts the first plunger 2b within the first dosing chamber 3, while the second plunger 3b further advances within the second dosing chamber 3. The amount of the liquid drug aspirated into the first dosing chamber 2 by retracting the first plunger 2b within the first dosing chamber 2 is equal to one or more times the first minimum dosing amount. At the same time, the amount of the liquid drug dispensed from the second dosing chamber 3 by further advancing the second plunger 3b within the second dosing chamber 3 is equal to the amount of the liquid drug aspirated into the first dosing chamber 2. Therefore, the total amount of the liquid drug dispensed through the outlet 5 of the fluid line 4 is zero. Thus, through this operating mode, the liquid drug is completely transferred from the second dosing chamber 3 into the first dosing chamber 2.

[0036] Similarly, as Figure 2d schematically visualized in, the liquid drug can be transferred from the first dosing chamber 2 into the second dosing chamber 3 through the fourth operating mode. The operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by the controller 6. Under the control of the controller, the first drive mechanism 2a is operated to further advance the first plunger 2b within the first dosing chamber 2, while the second drive mechanism 3a is operated to simultaneously retract the second plunger 3b within the second dosing chamber 3. The amount of the liquid drug dispensed from the first dosing chamber 2 is equal to one or more times the first minimum dosing amount. The amount of the liquid drug aspirated into the second dosing chamber 3 by retracting the second plunger 3b within the second dosing chamber 3 is equal to the amount of the liquid drug provided by the first dosing chamber 2, and is also equal to one or more times the second minimum dosing amount.

[0037] List of reference numerals

[0038] 1 Medical infusion device system

[0039] 2 First dosing chamber

[0040] 2a First driving mechanism

[0041] 2b First plunger

[0042] 3 Second dosing chamber

[0043] 3a Second driving mechanism

[0044] 3b Second plunger

[0045] 4 Fluid pipeline

[0046] 5 Outlet of the fluid pipeline

[0047] 6 Controller

Claims

1. A medical infusion device system (1), comprising ● A first dosing chamber (2) configured to deliver a first minimum dose of one or more multiples of a liquid drug; · A second dosing chamber (3) configured to deliver a second minimum dose of one or more multiples of the liquid drug; · A fluid line (4) operatively coupled to the first dosing chamber (2) and the second dosing chamber (3) for delivering a total amount of liquid drug through an outlet (5) of the fluid line (4), the total amount of liquid drug being provided by the first dosing chamber (2) and the second dosing chamber (3); and · A controller (6) configured to control the operation of the first dosing chamber (2) and the second dosing chamber (3) to provide the total amount of liquid drug via the fluid line (4), wherein, The second minimum dose of the liquid drug provided by the second dosing chamber (3) is greater than the first minimum dose of the liquid drug provided by the first dosing chamber (2).

2. The medical infusion device system (1) according to claim 1, wherein, The controller (6) is configured to control the simultaneous operation of the first dosing chamber (2) and the second dosing chamber (3) for transferring the liquid drug to the second dosing chamber (3) in an amount equal to one or more times the first minimum dose of the liquid drug and / or for transferring the liquid drug to the first dosing chamber (2) in an amount equal to one or more times the second minimum dose of the liquid drug.

3. The medical infusion device system (1) according to claim 1 or 2, wherein, The controller (6) is configured to control the simultaneous operation of the first dosing chamber (2) and the second dosing chamber (3) for delivering the total amount of the liquid drug via the fluid line (4) and through the outlet (5), wherein the total amount of the liquid drug is equal to the sum or difference of one or more times the first minimum dose of the liquid drug and one or more times the second minimum dose of the liquid drug, and wherein the total amount of the liquid drug delivered through the outlet (5) is equal to or greater than zero.

4. The medical infusion device system (1) according to any one of claims 1 to 3, wherein, The first dosing chamber (2) is operatively coupled to a first drive mechanism (2a) configured to actuate the first dosing chamber (2), and the second dosing chamber (3) is operatively coupled to a second drive mechanism (3a) configured to actuate the second dosing chamber (3), wherein the controller (6) is configured to control the operation of the first drive mechanism (2a) and the second drive mechanism (3a).

5. The medical infusion device system (1) according to claim 4, wherein, The first dosing chamber (2) is a first reservoir configured to contain the liquid drug, wherein the first dosing chamber includes a first plunger (2b) movably disposed within the first reservoir for delivering the first minimum dose of the liquid drug one or more times when actuated by the first drive mechanism (2a), and the second dosing chamber (3) is a second reservoir configured to contain the liquid drug, wherein the second dosing chamber (3) includes a second plunger (3b) movably disposed within the second reservoir for delivering the second minimum dose of the liquid drug one or more times when actuated by the second drive mechanism (3a).

6. The medical infusion device system (1) according to claim 5, wherein, The first reservoir has a first cross-section, and the second reservoir has a second cross-section different from the first cross-section.

7. The medical infusion device system (1) according to any one of claims 1 to 6, wherein, The second minimum dose is equal to an integer multiple of the first minimum dose.

8. A method for operating a medical infusion device system (1) according to any one of claims 1 to 7, wherein, The controller (6) controls the operation of the first dosing chamber (2) and the second dosing chamber (3) for providing the total amount of the liquid drug via the fluid line (4), wherein the total amount of the liquid drug is equal to or greater than zero, and the total amount of the liquid drug is equal to one or more times the first minimum dose plus or minus one or more times the second minimum dose.

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