Material taking device and material taking method for cervical conization specimen

Abstract

The invention provides a sampling device for a cervical conization specimen and a method for sampling the cervical conization specimen by using the sampling device, the sampling device comprises a sampling device and a sampling chopping board, the sampling device penetrates through a hollow cavity of the cervical conization specimen to be matched with a concave part on the sampling chopping board, and movable parts of the sampling device move relatively to realize sampling of the cervical conization specimen. And the cervical conization specimen between the sampling device and the sampling chopping board is cut. The cervical conization specimen can be equally divided, so that average distribution can be ensured, errors caused by manual operation can be reduced, the operation time can be shortened, the working efficiency can be improved, and most importantly, the risk of misdiagnosis and misjudgment can be reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a sampling device and a sampling method for cervical conization specimens. Background Art

[0002] Cervical cancer is a common malignant tumor that seriously threatens women's health and has become a major global public health problem. In the secondary prevention of cervical cancer prevention and treatment, carrying out cervical cancer screening and diverting those with abnormal screening results are important management links.

[0003] According to epidemiological statistics, in 2020, the number of newly diagnosed cervical cancer cases in China reached 1.09 million, and the number of deaths reached 0.59 million. Currently, the incidence and mortality of cervical cancer in China are still on the rise. The 5-year overall survival rate of cervical cancer patients is 68%, while the survival rate of patients with recurrent or metastatic cervical cancer is still poor, only 17%. If timely and effective diagnosis, treatment, and management of cervical precancerous lesions and early invasive cancer can be carried out, the incidence of recurrent or metastatic cervical cancer can be reduced and the survival rate of patients can be improved. Therefore, in the current application of clinical diagnosis and treatment technologies, reliable methods for early diagnosis and treatment of cervical cancer are still needed.

[0004] Early cervical lesions are detected through screening. The main screening methods include cervical cytology examination, HPV DNA detection, ploidy analysis, and DNA methylation technology, etc. Through screening, these patients are stratified and diverted for management, and positive cases are screened out for further treatment. Among them, some patients need to undergo cervical biopsy and subsequent cervical conization examination. Therefore, the pathological sampling and pathological diagnosis of cervical conization specimens are very important in clinical work.

[0005] In the routine sampling of pathological specimens in the pathology department, an ordinary medical pathological sampling knife is used. The cervical conization specimen needs to be placed according to the clinically marked orientation, the cut edges of the internal os, external os, and lateral edges of the cervix are inked, and then cut in a clockwise direction in turn. It is required to equally divide each point like a clock, and all samples are taken at 12 o'clock and placed in 12 embedding cassettes for all embedding. This requires high skills from pathologists and takes a long time.

[0006] Currently, there is no suitable sampling knife that can integrally fix and cut the cervical conization specimen, which is likely to cause uneven distribution of each point of the cervix, increasing the risk of misdiagnosis and misjudgment, and also consuming more time of pathologists.

[0007] Therefore, there is an urgent need for a sampling device for cervical conization specimens to improve the sampling efficiency and accuracy of cervical conization specimens. Summary of the Invention

[0008] In order to solve the deficiencies of the existing technologies, the objective of the present invention is to provide a sampling device and a sampling method for cervical conization specimens, so as to equally divide the cervical conization specimens, shorten the operation time, improve the work efficiency, and reduce the risk of misdiagnosis and misjudgment.

[0009] To achieve the above objective, in the first aspect of the present invention, a sampling device for cervical conization specimens is provided. The sampling device includes: a sampler and a sampling anvil. The sampler passes through the hollow cavity of the cervical conization specimen and cooperates with the recess on the sampling anvil. The movable component of the sampler moves relatively, and cuts the cervical conization specimen located between the sampler and the sampling anvil. The sampler includes: a cutting assembly and a positioning assembly. The cutting assembly includes: a plurality of cutting knives, a cutting knife fixing rod, a pressing handle, a stop element, and a spring; the positioning assembly includes: a positioning sleeve, a gripping handle, and a positioning rod; the cutting knife fixing rod is a hollow member, and a part of it is sleeved on the positioning rod. Among them,

[0010] A plurality of cutting knives are installed on the cutting knife fixing rod. The pressing handle is threadedly connected to the cutting knife fixing rod. The stop element is installed on the cutting knife fixing rod, and the spring is sleeved on the lower part of the cutting knife fixing rod;

[0011] The positioning sleeve has a middle penetrating part. The middle penetrating part has a plurality of slots. The plurality of slots respectively correspond to the plurality of cutting knives one by one, so that each cutting knife penetrates the corresponding slot and radially extends to a certain distance outside the radial direction of the positioning sleeve. The certain distance enables the cutting knife to completely cover the cervical conization specimen when cutting downward, so as to completely cut the cervical conization specimen into multiple equally divided samples. In an embodiment of the first aspect, the cutting knife fixing rod includes: a spring installation part, a cutting knife installation part, and a handle connection part. Among them,

[0012] The spring installation part is located at the lower part of the cutting knife fixing rod, and a spring is sleeved on its outer part;

[0013] The cutting knife installation part is located above the spring installation part, and a plurality of cutting knives are evenly distributed around the cutting knife installation part along the circumferential direction of the cutting knife installation part;

[0014] The handle connection part is located at the upper part of the cutting knife fixing rod, and a thread is provided on its outer part for threaded connection with the pressing handle.

[0015] In an embodiment of the first aspect, a groove is provided at a position near the handle connection part at the upper part of the cutting knife fixing rod for installing the stop element.

[0016] In an embodiment of the first aspect, the pressing handle has a threaded connection end and a pressing end. The pressing end is in a dome shape, and the threaded connection end is used for threaded connection with the handle connection part.

[0017] In an embodiment of the first aspect, the positioning sleeve further includes: a closed end and an open end, wherein,

[0018] Threads are provided on the outside of the open end for threaded connection with the gripping handle;

[0019] The outside of the closed end is U-shaped similar to the bottom of a test tube, and the inner bottom end thereof is a flat plane;

[0020] A positioning rod is provided at the central position of the flat plane at the inner bottom end of the closed end.

[0021] In an embodiment of the first aspect, the gripping handle has an outer gripping portion, a first through hole and a threaded connection hole, wherein,

[0022] The first through hole is in clearance fit with the cutting knife fixing rod;

[0023] The threaded connection hole is used to cooperate with the threads provided on the outside of the open end of the positioning sleeve;

[0024] Wherein, the first through hole and the threaded connection hole are coaxially arranged, and the diameter of the first through hole is smaller than the diameter of the threaded connection hole, forming a stop portion of the gripping handle, and the stop element cooperates with the stop portion to limit the stroke range of the cutting knife fixing rod.

[0025] In an embodiment of the first aspect, a recessed structure or pattern is provided on the outer gripping portion.

[0026] In an embodiment of the first aspect, the specimen cutting board includes a flat bottom and an upper part with a positioning recess, wherein,

[0027] The positioning recess is arranged at the central position of the upper part of the specimen cutting board, and its shape matches the outside of the closed end of the positioning sleeve to position the positioning sleeve.

[0028] In an embodiment of the first aspect, the spring can vary between a first position and a second position, wherein, at the first position, the flange of the stop element abuts against the stop portion of the gripping handle, and a plurality of cutting knives are located above the cervical conization specimen; at the second position, the cutting edges of the plurality of cutting knives abut against the upper surface of the upper part of the specimen cutting board.

[0029] To achieve the above object, in the second aspect of the present invention, there is provided a method for taking a cervical conization specimen using the above-mentioned specimen taking device for cervical conization specimens, including:

[0030] Placing the cervical conization specimen on the specimen cutting board such that the hollow cavity of the cervical conization specimen is aligned with the positioning recess on the specimen cutting board;

[0031] Insert the sampler into the hollow cavity of the cervical conization specimen and cooperate with the positioning recess on the sampling anvil;

[0032] Hold the outside of the gripping handle of the sampler, and at the same time press down the pressing handle of the sampler to cut and sample the cervical conization specimen;

[0033] Among them, the various states of the sampling device when cutting the cervical conization specimen are as follows:

[0034] When the sampling device starts to cut the cervical conization specimen, the sampler is in the initial position. Among them, the spring is in the first compressed state. In the first compressed state, the flange of the stop element abuts against the stop portion of the gripping handle, and multiple cutting blades are located above the cervical conization specimen;

[0035] When the sampling device cuts the cervical conization specimen, the pressing handle is pressed down, and the cutting blade fixing rod connected to the pressing handle slides down along the positioning rod, and multiple cutting blades move down accordingly to cut the cervical conization specimen;

[0036] When the sampling device finishes cutting the cervical conization specimen, the sampler is in the final position. Among them, the spring is in the second compressed state. In the second compressed state, the cutting edges of multiple cutting blades abut against the upper surface of the upper part of the sampling anvil.

[0037] Advantageous effects

[0038] The sampling device for cervical conization specimens of the present invention has the following advantageous effects:

[0039] (1) The specimen can be evenly divided, which can not only ensure average distribution, reduce the error of manual operation, but also shorten the operation time, improve work efficiency, and most importantly, reduce the risk of misdiagnosis and misjudgment.

[0040] (2) The fixation and cutting of the cervical conization specimen are realized through a simple design.

[0041] Other features and advantages of the present invention will be described in the subsequent specification, and part of them will become obvious from the specification, or will be understood by implementing the present invention. Description of the drawings

[0042] The drawings are used to provide a further understanding of the present invention, and constitute a part of the specification, and together with the embodiments of the present invention, are used to explain the present invention, and do not constitute a limitation to the present invention. In the drawings:

[0043] Figure 1 It is a schematic diagram of the sampling device for cervical conization specimens according to an embodiment of the present invention;

[0044] Figure 2 It is a perspective view of the sampler;

[0045] Figure 3 is a perspective view of the cutting assembly;

[0046] Figure 4 is a perspective view of the cutting tool fixing rod;

[0047] Figure 5 is a perspective view of the positioning assembly;

[0048] Figure 6 is a perspective view of the positioning sleeve;

[0049] Figure 7 is a perspective view of the gripping handle;

[0050] Figure 8 is a perspective view of the material cutting chopping board. Detailed implementation manners

[0051] Embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although some embodiments of the present invention are shown in the drawings, it should be understood that the present invention can be implemented in various forms and should not be construed as limited to the embodiments set forth herein. On the contrary, these embodiments are provided to more thoroughly and completely understand the present invention. It should be understood that the drawings and embodiments of the present invention are only for exemplary purposes and are not used to limit the protection scope of the present invention.

[0052] It should be understood that the steps recited in the method embodiments of the present invention can be executed in a different order and / or executed in parallel. In addition, the method embodiments may include additional steps and / or omit the steps shown. The scope of the present invention is not limited in this regard.

[0053] As used herein, the term "including" and its variants are open-ended, that is, "including but not limited to". The term "based on" is "at least partially based on". The term "one embodiment" means "at least one embodiment"; the term "another embodiment" means "at least one additional embodiment"; the term "some embodiments" means "at least some embodiments". The relevant definitions of other terms will be given in the following description.

[0054] It should be noted that the modifications of "one" and "multiple" mentioned in the present invention are illustrative rather than restrictive. Those skilled in the art should understand that unless otherwise clearly specified in the context, it should be understood as "one or more". "Multiple" should be understood as two or more.

[0055] Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

[0056] Embodiment 1

[0057] Figure 1shows a sampling device for cervical conization specimens according to Embodiment 1 of the present invention, which consists of Figure 1 As can be seen, the sampling device for cervical conization specimens of the present invention includes: a sampler 1 and a sampling anvil 2. During operation, the sampler 1 passes through the hollow cavity of the cervical conization specimen ( Figure 1 shown by the dotted line therein) and cooperates with the recess on the sampling anvil 2, and the movable part of the sampler 1 moves relatively to cut the cervical conization specimen located between the sampler 1 and the sampling anvil 2.

[0058] Figure 2 shows a perspective view of the sampler, as Figure 2 shown, the sampler 1 includes: a cutting assembly 10 and a positioning assembly 11. The cutting assembly 10 and the positioning assembly 11 are combined to form the sampler 1.

[0059] Figure 3 shows a perspective view of the cutting assembly, as Figure 3 shown, the cutting assembly 10 includes: a plurality of cutting knives 101, a cutting knife fixing rod 102, a pressing handle 103, a stop element 104 and a spring (not shown). The plurality of cutting knives 101 are mounted on the cutting knife fixing rod 102, the pressing handle 103 is threadedly connected to the cutting knife fixing rod 102, the stop element 104 is mounted on the cutting knife fixing rod 102, and the spring is sleeved on the lower part of the cutting knife fixing rod 102.

[0060] Figure 4 The cutting knife fixing rod is shown separately, as Figure 4 shown, the cutting knife fixing rod 102 includes: a spring mounting portion 1021, a cutting knife mounting portion 1022, and a handle connecting portion 1023. The spring mounting portion 1021 is located at the lower part of the cutting knife fixing rod 102, and its outer diameter size is smaller than the outer diameter size of the cutting knife mounting portion 1022. The spring is sleeved on the outside of the spring mounting portion 1021. The cutting knife mounting portion 1022 is located above the spring mounting portion 1021, and the plurality of cutting knives 101 are circumferentially distributed around the cutting knife mounting portion 1022. Preferably, the plurality of cutting knives 101 are welded and fixed to the circumference of the cutting knife mounting portion 1022. The handle connecting portion 1023 is located at the upper part of the cutting knife fixing rod 102, and its outside is provided with a thread for threadedly connecting with the pressing handle 103. A groove 1024 is provided at a position near the handle connecting portion 1023 at the upper part of the cutting knife fixing rod 102 for mounting the stop element 104.

[0061] It should be particularly noted that the inside of the cutting knife fixing rod 102 is a hollow structure to cooperate with the positioning assembly 11 to realize the positioning of the cutting assembly 10.

[0062] For cervical conization specimens, the cervical conization specimens need to be evenly divided into 12 parts. Therefore, multiple cutting knives are preferably arranged in 12 pieces.

[0063] In addition, the pressing handle 103 has a threaded connection end and a pressing end. The pressing end is in a dome shape. For an ergonomic design, it is convenient for the hand to apply a downward pressing force on the pressing handle 103. The threaded connection end is used for threaded connection with the handle connection part 1023.

[0064] Figure 5 The schematic diagram of the positioning component is shown, as Figure 5 shown, the positioning component 11 includes: a positioning sleeve 111, a gripping handle 112 and a positioning rod 113. The positioning rod 113 is arranged at the middle position of the bottom of the positioning sleeve 111, and the gripping handle 112 is in threaded fit with the upper part of the positioning sleeve 111.

[0065] The positioning sleeve 111 is as Figure 6 shown and includes: a closed end 1111, an open end 1112 and an intermediate penetrating part 1113. The outside of its open end 1112 is provided with threads for threaded connection with the gripping handle 112. The outside of the closed end 1111 of the positioning sleeve 111 is in a U shape similar to the bottom of a test tube, and the inner bottom end thereof is a flat plane. The positioning rod 113 is arranged at the center position of the flat plane at the inner bottom end of the closed end 1111 of the positioning sleeve 111, and is used to insert into the hollow interior of the cutter fixing rod 102 when assembled with the cutting component 10, so that the cutter fixing rod 102 slides along the surface of the positioning rod 113. An intermediate penetrating part 1113 is opened above the closed end 1111 of the positioning sleeve 111, and the intermediate penetrating part 1113 penetrates through to the open end 1112. The intermediate penetrating part 1113 has a plurality of slots, and the plurality of slots respectively correspond one by one to the plurality of cutting knives 101 installed on the cutter fixing rod 102. Each cutting knife installed on the cutter fixing rod 102 penetrates through the corresponding slot provided on the intermediate penetrating part and radially extends to a certain distance outside the radial direction of the positioning sleeve. This certain distance enables the cutting knife to completely cover the cervical conization specimen when cutting downward, so as to completely cut the cervical conization specimen into multiple evenly divided samples.

[0066] Figure 7 The gripping handle is shown, as Figure 7As shown, the grasping handle 112 has an outer grasping portion 1121, a first through hole 1122, and a threaded connection hole 1123. The first through hole 1122 has a clearance fit with the cutting knife fixing rod 102. The threaded connection hole 1123 is used for mating with the thread provided on the outside of the open end 1112 of the positioning sleeve. The first through hole 1122 and the threaded connection hole 1123 are coaxially arranged, but the diameter of the first through hole 1122 is smaller than the diameter of the threaded connection hole 1123, forming a stop portion of the grasping handle 112. The stop element 104 installed in the upper groove of the cutting knife fixing rod 102 cooperates with the stop portion of the grasping handle 112, thereby restricting the stroke range of the cutting knife fixing rod 102. A recessed structure or pattern is provided on the outer grasping portion 1121 to increase the frictional force between the hand and the grasping handle and prevent the hand from slipping on the grasping handle when the hand is wet.

[0067] Figure 8 A material-taking cutting board is shown, such as Figure 8 As shown, the material-taking cutting board 2 includes a flat bottom 21 and an upper portion 22 having a positioning recess 221. The positioning recess 221 is arranged at the central position of the upper portion of the material-taking cutting board. The shape of the positioning recess 221 matches the outside of the closed end 1111 of the positioning sleeve 111 to position the positioning sleeve 111.

[0068] Embodiment 2

[0069] In this embodiment, the present invention provides a method for taking materials from a cervical conization specimen by using the above-mentioned material-taking device for cervical conization specimens. The method includes the following steps:

[0070] Place the cervical conization specimen on the material-taking cutting board such that the hollow cavity of the cervical conization specimen is aligned with the positioning recess on the material-taking cutting board;

[0071] Insert the material-taking device into the hollow cavity of the cervical conization specimen and cooperate with the positioning recess on the material-taking cutting board;

[0072] Grasp the outside of the grasping handle of the material-taking device and simultaneously press down the pressing handle of the material-taking device to cut and take materials from the cervical conization specimen;

[0073] The states of the material-taking device during cutting the cervical conization specimen are as follows:

[0074] When the material-taking device starts to cut the cervical conization specimen, the material-taking device 1 is in the initial position. Among them, the spring is in the first compressed state. In this first compressed state, the flange of the stop element 104 abuts against the stop portion of the grasping handle 112, and the plurality of cutting knives 101 are located above the cervical conization specimen;

[0075] When the sampling device cuts the cervical conization specimen, the pressing handle 103 is pressed down, and the cutting tool fixing rod 102 connected to the pressing handle 103 slides down along the positioning rod 113, and the plurality of cutting tools 101 move downward accordingly to cut the cervical conization specimen;

[0076] When the sampling device finishes cutting the cervical conization specimen, the sampler 1 is in the terminal position. Among them, the spring is in the second compressed state. In this second compressed state, the cutting edges of the plurality of cutting tools 101 abut against the upper surface of the upper part 22 of the sampling anvil 2.

[0077] It can be understood that when the pressing force on the pressing handle 103 is released, the spring returns to the first compressed state, and the sampler 1 returns to the initial position again.

[0078] Those of ordinary skill in the art can understand that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A device for collecting cervical conization specimens, characterized in that: The material collection device comprises: a material collection device and a material collection anvil. The material collection device passes through the hollow cavity of the cervical conization specimen and cooperates with the concave portion on the material collection anvil. The movable part of the material collection device moves relatively to cut the cervical conization specimen between the material collection device and the material collection anvil. The material collection device comprises: a cutting assembly and a positioning assembly. The cutting assembly comprises: a plurality of cutting knives, a cutting knife fixing rod, a pressing handle, a stop element and a spring. The positioning assembly comprises: a positioning sleeve, a gripping handle and a positioning rod. The cutting knife fixing rod is a hollow component, and a part of it is sleeved on the positioning rod, wherein, A plurality of cutting knives are installed on a cutting knife fixing rod, a pressing handle is threadedly connected to the cutting knife fixing rod, a stopper element is installed on the cutting knife fixing rod, and a spring sleeve is arranged at the lower part of the cutting knife fixing rod; The positioning sleeve has a middle penetration portion, which has a plurality of narrow grooves. The plurality of narrow grooves correspond to the plurality of cutting knives one by one, so that each cutting knife penetrates the corresponding narrow groove and radially extends to a certain distance radially outside the positioning sleeve. The certain distance allows the cutting knife to completely cover the cervical cone specimen when cutting downward, thereby completely cutting the cervical cone specimen into a plurality of equally divided samples.

2. The device for collecting cervical conization specimens according to claim 1, characterized in that: The cutting knife fixing rod comprises: a spring mounting portion, a cutting knife mounting portion, and a handle connecting portion, wherein: The spring installation part is located at the lower part of the cutting knife fixing rod, and a spring is sleeved on the outside of the spring installation part; The cutting blade installation part is located above the spring installation part, and a plurality of cutting blades are evenly distributed around the cutting blade installation part along the circumference of the cutting blade installation part; The handle connecting portion is located at the upper part of the cutting knife fixing rod, and a thread is arranged on the outside of the handle connecting portion for being threadedly connected with the pressing handle.

3. The device for collecting cervical conization specimens according to claim 2, characterized in that: A groove is arranged at a position on the upper part of the cutting knife fixing rod near the handle connecting part for installing a stop element.

4. The device for collecting cervical conization specimens according to claim 2, characterized in that: The pressing handle has a threaded connection end and a pressing end, the pressing end is in a dome shape, and the threaded connection end is used for threaded connection with the handle connection part.

5. The device for collecting cervical conization specimens according to claim 1, characterized in that: The positioning sleeve also includes a closed end and an open end, wherein The outer side of the open end is provided with a thread for threaded connection with the grip handle; The closed end is externally U-shaped similar to the bottom of a test tube, and its internal bottom end is a flat surface; Wherein, a positioning rod is arranged at the center position of the flat plane of the inner bottom end of the closed end.

6. The device for collecting cervical conization specimens according to claim 5, characterized in that: The grip handle has an outer grip portion, a first through hole and a threaded connection hole, wherein: The first through hole is in clearance fit with the cutting knife fixing rod; The threaded connection hole is used to cooperate with the thread provided on the outer side of the open end of the positioning sleeve; The first through hole and the threaded connection hole are coaxially arranged, and the diameter of the first through hole is smaller than the diameter of the threaded connection hole, forming a stop portion of the gripping handle, and the stop element cooperates with the stop portion to limit the travel range of the cutting knife fixing rod.

7. The device for collecting cervical conization specimens according to claim 6, characterized in that: A recessed structure or pattern is provided on the outer gripping portion.

8. The device for obtaining cervical conization specimens according to claim 6, characterized in that: The cutting board comprises a flat bottom and an upper portion with a positioning recess, wherein: The positioning recess is arranged at the center of the upper part of the cutting board, and its shape matches the outer part of the closed end of the positioning sleeve to position the positioning sleeve.

9. The device for collecting cervical conization specimens according to claim 6, characterized in that: The spring can change between a first position and a second position, wherein, in the first position, the flange of the stop element abuts against the stop portion of the gripping handle, and multiple cutting knives are located above the cervical conization specimen; in the second position, the cutting edges of the multiple cutting knives abut against the upper surface of the upper part of the sampling anvil.

10. A method for obtaining a cervical conization specimen using the device for obtaining a cervical conization specimen according to any one of claims 6 to 9, comprising: Placing the cervical conization specimen on the cutting board so that the hollow cavity of the cervical conization specimen is aligned with the positioning recess on the cutting board; Insert the sampling device into the hollow cavity of the cervical conization specimen and match it with the positioning recess on the sampling cutting board; Hold the outside of the grab handle of the sampler and press the pressing handle of the sampler downward to cut and sample the cervical conization specimen; The various states of the sampling device when cutting the cervical conization specimen are as follows: When the sampling device starts cutting the cervical conization specimen, the sampling device is in an initial position, wherein the spring is in a first compressed state, in which the flange of the stop element abuts against the stop portion of the gripping handle, and the plurality of cutting knives are located above the cervical conization specimen; When the sampling device cuts the cervical conization specimen, the pressing handle is pressed, and the cutting knife fixing rod connected to the pressing handle slides downward along the positioning rod, and the multiple cutting knives move downward to cut the cervical conization specimen; When the sampling device finishes cutting the cervical conization specimen, the sampling device is in the final position, wherein the spring is in the second compressed state, in which the cutting edges of the plurality of cutting knives abut against the upper surface of the upper portion of the sampling anvil.

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