Microneedle application device and microneedle patch packaging box thereof
By designing a micro-needle patching device, the combination of semi-enclosed cavity, pressure block and air extraction components is used to solve the problem of stable fit and micro-needle damage during the micro-needle patching application process, and the bubble-free and sterile patching effect is achieved, and the dissolution effect of micro-needle is improved.
Patent Information
- Application Number
- CN202510528218.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-25
- Publication Date
- 2025-06-24
AI Technical Summary
During the application process, it is difficult to firmly fit the skin, and it is prone to bubbles and uneven stress. The prior art pressure method or the use of needle inserters will damage the microneedle and affect the dissolution effect.
A micro-needle patching device is designed, including a semi-enclosed cavity, a pressure block and an air-exhaust assembly, which is sealed with the skin through the semi-enclosed cavity, and presses the micro-needle array and provides negative pressure through the air-exhaust assembly to assist the micro-needle to penetrate the skin.
The micro-needle patch is bubble-free and firmly applied to the skin surface, avoiding micro-needle damage, improving the dissolution effect of the micro-needle array, and achieving sterile operation.
Smart Images
Figure CN120189624A_ABST
Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of microneedle application, and particularly relates to a microneedle application device and a microneedle patch packaging box thereof. Background Art
[0002] As a drug delivery technology, microneedle drug delivery technology has advantages such as high user compliance, low dosage, and high safety. In recent years, microneedles have been widely used in the fields of drug delivery and medical aesthetics due to their ability to penetrate the skin and deliver active ingredients. After being made into microneedle patches, the microneedles are applied to the skin surface, and the microneedle array is completely inserted into the skin by pressing, so as to achieve the effect of drug delivery. The size of the microneedles is very fine, and the mechanics of the human skin surface are complex. During the actual application process of the microneedle patch, due to differences in the age and gender of users, there are certain differences in their skin conditions, stratum corneum thickness, and pressing force. It is difficult to master the appropriate force to insert the microneedles into the skin. If the force is too large, the microneedles are prone to breakage and deformation. If the force is too small, the microneedles cannot penetrate the skin stratum corneum. Moreover, the curvature of the skin will also cause uneven stress on the microneedle patch, making it difficult to apply, and it is impossible to achieve the effect of no bubbles and stable application.
[0003] In the prior art, the method of applying pressure is commonly used to improve the problem of uneven stress when applying the microneedle patch. The effect of applying pressure is similar to that of manual pressing, or the microneedle patch is pre-placed in the injector for application, which limits the use of the microneedle patch, and the microneedles are easily damaged during application, affecting the dissolution effect of the microneedle array. Therefore, it is necessary to study a microneedle application device that is convenient to carry and simple to use, so that users can easily take out the microneedle patch from the microneedle patch packaging box and apply it, without damaging the shape of the microneedles, ensuring that the microneedle patch is applied to the skin surface without bubbles, improving the dissolution effect of the microneedles; and it can also achieve aseptic operation during application, avoiding damage or contamination of the microneedle array when tearing the release paper. Summary of the Invention
[0004] To solve the above technical problems, the present invention provides a microneedle application device and a microneedle patch packaging box thereof.
[0005] The microneedle application device includes a housing, a semi-closed cavity surrounded by the housing, a pressure block disposed in the semi-closed cavity, and an air extraction assembly; the fixed end of the pressure block extends into the semi-closed cavity and is fixedly connected to the top of the semi-closed cavity, and the free end of the pressure block is flush with the open end of the semi-closed cavity; when the microneedle application device works, the open end of the semi-closed cavity fits against the skin to form a sealed cavity, surrounding the microneedle patch attached to the skin therein, the free end of the pressure block presses at least on the microneedle array area of the microneedle patch, and the air extraction assembly provides negative pressure for the sealed cavity.
[0006] The overall shape of the microneedle application device is approximately "L"-shaped, allowing the user to operate the microneedle application device with one hand. When the microneedle application device is working, the semi-closed cavity fits against the skin surface to surround the microneedle patch adhered to the skin. The pressure block corresponds to the microneedle array of the microneedle patch. The open end of the semi-closed cavity contacts the skin surface to form a seal inside the semi-closed cavity. When the air extraction component extracts air from the semi-closed cavity, a negative pressure is formed inside it, causing the skin surface to deform towards the semi-closed cavity. The skin approaching the microneedle patch helps the microneedle array to pierce the skin, and at the same time, the edge of the microneedle patch closely adheres to the skin surface.
[0007] Preferably, a flange is provided on the side of the pressure block near the free end, and a boss is provided on the free end face of the pressure block. When the microneedle application device is working, the boss at least presses on the microneedle array area of the microneedle patch.
[0008] The flange divides the semi-closed cavity into an inner cavity and an outer cavity that communicate with each other. The inner cavity is arranged on the side close to the fixed end of the pressure block, and the outer cavity is arranged on the side close to the free end of the pressure block. The surface of the boss that is flush with the open end of the semi-closed cavity is the support surface. When the microneedle application device is working, the support surface presses on the microneedle array area of the microneedle patch, and the plane of the flange close to the open end of the semi-closed cavity abuts against the edge of the microneedle patch. During the deformation of the skin towards the semi-closed cavity, the microneedle array pierces into the skin, and the skin adheres tightly to the edge of the microneedle patch.
[0009] Preferably, the microneedle application device further includes at least two mechanical claws and an actuating assembly. The mechanical claws are arranged around the free end of the pressure block inside the semi-closed cavity. When the microneedle application device is working, the mechanical claws perform a reciprocating motion of extending and retracting into the semi-closed cavity under the drive of the actuating assembly to clamp or release the microneedle patch.
[0010] Preferably, the arm of the mechanical claw extends into the semi-closed cavity through the gap between the flange and the inner wall of the housing and is connected to the actuating assembly. When the claw of the mechanical claw retracts, it is limited by the flange.
[0011] Gaps are provided between the flange and the arm of the mechanical claw and between the arm of the mechanical claw and the inner wall of the semi-closed cavity to facilitate the up and down movement of the mechanical claw. This gap enables the inner cavity and the outer cavity of the semi-closed cavity to communicate, which is beneficial for the air extraction component to extract air from the semi-closed cavity and exhaust all the gas inside the semi-closed cavity.
[0012] Preferably, the actuating assembly includes a push rod, an actuating rod connecting the mechanical claws, and a linkage connecting the push rod and the actuating rod. The actuating assembly is configured such that when the push rod is repeatedly pressed, the actuating rod performs a reciprocating motion under the drive of the linkage.
[0013] The linkage member includes a movable block and a push plate. The push plate is arranged at the bottom of the push rod. The movable block arranged on the movable rod is fixedly connected to the push plate. By pressing the push rod, the movable rod reciprocates in the housing and the semi-closed cavity under the driving action of the push plate and the movable block.
[0014] Preferably, the mechanical claw is L-shaped. After the mechanical claw extends out of the semi-closed cavity, its arm is inclined at 0-45° to open and clamp the microneedle patch.
[0015] When the movable rod moves downward to make the mechanical claw extend out of the semi-closed cavity, the arm of the mechanical claw is inclined at 0-45° to open and clamp the microneedle patch. The inclination angle of the arm of the mechanical claw is adjusted according to the size of the microneedle patch.
[0016] Preferably, the microneedle application device further includes a thin spring arranged in the semi-closed cavity and a thick spring arranged below the linkage member. The thin spring and the thick spring are used to control the mechanical claw to extend out of the open end of the semi-closed cavity and retract into the semi-closed cavity.
[0017] The thick spring is arranged below the push plate. One end of it is connected to the push plate, and the other end abuts against the bottom of the housing. The thin spring is sleeved on the pressure block. One end of it is connected to the mechanical claw, and the other end is connected to the top of the semi-closed cavity. When the push rod is pressed to move downward, the push plate receives the downward force of the push rod, so that the push plate and the movable block move downward at the same time to compress the thick spring. The movable block drives the movable rod to move downward. The thin spring changes from the compressed state to the relaxed state. The movable rod and the thin spring cooperate to make the mechanical claw move downward to extend out of the open end of the semi-closed cavity. When the push rod is pressed again to move upward, the push plate moves upward under the action of the rebound of the thick spring. At the same time, the movable block moves upward to drive the movable rod to move upward to return to the initial position. The thin spring changes from the relaxed state to the compressed state, and the mechanical claw moves upward to retract into the semi-closed cavity.
[0018] The mechanical claw can not only move under the action of the elastic force of the thick spring and the driving action of the movable rod, but also be controlled to move independently by the elastic force of the thin spring. When the open end of the semi-closed cavity abuts against the skin surface, that is, the claw part of the mechanical claw abuts against the skin surface, the thin spring is in the compressed state. At this time, when the push rod is pressed, the push plate is forced to move downward to compress the thick spring, and the movable rod moves downward without being driven by the linkage member. When the microneedle application device is moved away from the skin surface, the thin spring changes from the compressed state to the relaxed state under the action of the elastic force, and the mechanical claw extends out of the open end of the semi-closed cavity, and at the same time drives the movable rod to move downward. The contact area between the mechanical claw and the microneedle patch is very small. When the microneedle application device is moved away from the skin surface after the application is completed, the mechanical claw will not cause tearing or pulling damage to the edge of the microneedle patch and affect the dissolution effect of the microneedle array after the microneedle patch is applied.
[0019] The movable components of the microneedle application device further include a limit ring and a buffer block fixed to the top of the movable rod, and a locking member provided on the top of the pressing rod. The limit ring is used to limit the upward limit of the movable block on the movable rod, preventing the pressing plate from quickly resetting under the elastic force of the thick spring and damaging the movable components. The buffer block made of rubber is arranged below the limit ring and is used to slow down the force generated by the rebound of the pressing plate and the upward movement of the movable block, preventing the rapid upward movement of the movable rod from causing the mechanical claw to quickly retract and tear the edge of the microneedle patch, damaging the microneedle patch, and also preventing the rapid upward movement of the movable rod from damaging the movable components.
[0020] The bottom end of the locking member is correspondingly arranged with the top end of the pressing rod, and a sleeve is provided on its outer side. The guide groove on the locking member corresponds to the guide rail on the sleeve; a pressing member is provided on the top of the locking member, and the meshing teeth at the bottom end of the pressing member correspond to the protrusions on the side wall of the locking member. When pressing, the pressing member slides along the protrusion on the side wall of the locking member, and the meshing teeth at the bottom end drive the locking member to rotate so that the guide groove of the locking member falls into the guide rail of the sleeve and engages, the pressing rod moves downward and is fixed. At this time, the thick spring is compressed, and the movable rod moves downward under the driving action of the pressing plate and the movable block, and the mechanical claw extends out of the semi-closed cavity; when pressing again, the meshing teeth at the bottom end of the pressing member drive the locking member to rotate so that the guide groove of the locking member slides out of the guide rail of the sleeve, and at the same time, the pressing member slides along the protrusion on the side wall of the locking member to make the pressing rod move upward. At this time, the thick spring rebounds, and the movable rod moves upward under the driving action of the pressing plate and the movable block, and the mechanical claw retracts into the semi-closed cavity.
[0021] Preferably, the air extraction component includes a vacuum source and an air extraction pipe. One end of the air extraction pipe is connected to the vacuum source, and the other end is connected to the semi-closed cavity.
[0022] An air extraction hole is provided at the top of the semi-closed cavity. One end of the air extraction pipe is connected to the vacuum source, and the other end is connected to the air extraction hole. When the air extraction component performs suction, a negative pressure is formed in the semi-closed cavity, and the skin covered at the bottom of the semi-closed cavity will be sucked up and close to the outer cavity. The inner cavity is the vacuum buffer area of the semi-closed cavity, and its volume should be kept within a suitable range. If the volume of the inner cavity is too small, the vacuum degree generated after air extraction is low, and the suction force of the outer cavity on the skin is small. Slight air leakage will cause the semi-closed cavity to fail to reach the required vacuum requirement. If the volume of the inner cavity is too large, the vacuum degree generated after air extraction is high, and the time and difficulty for the semi-closed cavity to reach the required vacuum requirement increase.
[0023] The present invention also provides a micro - needle patch packaging box, which includes a groove - shaped storage part for storing the micro - needle patch, a release paper for fixing the micro - needle patch, and a sealing cover for closing the storage part; the release paper is generally annular, the outer edge of the release paper is fixed on the outer edge of the storage part, and the inner edge of the release paper is separably adhered to the hydrogel edge of the micro - needle patch, so as to suspend and fix the tip area of the micro - needle patch facing the groove in the storage part; when the micro - needle patch packaging box is used for a micro - needle application device, the open end of the semi - enclosed cavity fits the back of the micro - needle patch, and under the negative pressure provided by the air - extraction component, it drives the micro - needle patch to leave the storage part while peeling off the release paper.
[0024] Preferably, a grasping groove is provided at the outer edge of the storage part corresponding to the position of the mechanical claw of the micro - needle application device, and a cut is provided at the corresponding position of the release paper; when the micro - needle patch packaging box is used for a micro - needle application device, the mechanical claw extends out of the semi - enclosed cavity and extends into the grasping groove, and when retracting, it cooperates with the pressure block to clamp the hydrogel edge of the micro - needle patch, and drives the micro - needle patch to leave the storage part while peeling off the release paper.
[0025] When the micro - needle application device and the micro - needle patch packaging box are used correspondingly, the mechanical claw of the micro - needle application device extends into the grasping groove of the micro - needle patch packaging box to clamp the hydrogel edge of the micro - needle patch, and the micro - needle patch in the micro - needle patch packaging box is taken out by controlling the expansion and contraction of the mechanical claw. The mechanical claw first extends into the grasping groove of the storage part of the micro - needle patch packaging box to clamp the micro - needle patch, and then retracts to take out the micro - needle patch while peeling off the release paper adhered to the hydrogel, and places the micro - needle patch on the skin surface. Under the action of the pressure block and the air - extraction component, the micro - needle patch is applied to the skin surface without bubbles. During this process, the user has no direct contact with the micro - needle patch, which can not only prevent the micro - needle patch from being contaminated before application and achieve sterile application, but also prevent damage to the micro - needle array area of the micro - needle patch due to improper handling, affecting the dissolution effect of the micro - needle array.
[0026] The usage process of the micro - needle application device and its micro - needle patch packaging box is as follows: (1) Press the button, the push rod moves downward, the push plate receives the downward force from the push rod, so that the push plate drives the movable block to move downward to compress the thick spring, the movable block drives the movable rod to move downward, and the mechanical claw extends out of the open end of the semi - enclosed cavity and extends into the grasping groove of the micro - needle patch packaging box; (2) Press the button again, the push rod moves upward, the push plate moves upward under the action of the rebound of the thick spring, at the same time the movable block drives the movable rod to move upward, the mechanical claw clamps the edge of the hydrogel of the micro - needle patch and retracts, takes out the micro - needle patch from the storage part while peeling off the release paper. At this time, the thick spring is in a relaxed state and the thin spring is in a compressed state; (3) Place the microneedle application device on the skin surface, such that the open end of the semi-closed cavity fits against the skin to surround the microneedle patch therein, forming a sealed cavity. The boss of the pressure block presses against the microneedle array area of the microneedle patch. Press the switch to activate the vacuum source to evacuate the semi-closed cavity. When a negative pressure is formed in the semi-closed cavity, the skin is sucked up and deformed to assist the microneedle array in piercing the skin. At the same time, the bubbles in the microneedle array are evacuated. The hydrocolloid at the edge of the microneedle patch adheres tightly to the skin surface. Press the switch again to turn off the vacuum source. (4) Press the button. The push plate moves downward under the downward force of the push rod. The thick spring is in a compressed state. Remove the microneedle application device from the skin surface. The thin spring changes from the compressed state to the relaxed state. The mechanical claw releases the microneedle patch under the action of the elastic force, and at the same time drives the movable rod downward. The sterile application is completed, and the microneedle patch is applied to the skin surface without bubbles.
[0027] The microneedle application device can be used in combination with the microneedle patch packaging box or used alone. The user can reasonably adjust the usage process and steps of the microneedle application device according to the needs of the usage scenario. When the user uses the microneedle application device alone, place the microneedle patch on the skin surface and then surround the microneedle patch with the semi-closed cavity of the microneedle application device. After the semi-closed cavity forms a sealed cavity, evacuate it to form a negative pressure in the semi-closed cavity, causing the skin surface to deform. The microneedle patch is applied to the skin surface without bubbles. If the user uses the mechanical claw of the microneedle application device to pick up the microneedle patch, after the mechanical claw extends out of the semi-closed cavity, the opening angle of the arm of the mechanical claw can be adjusted according to the size of the microneedle patch to pick up the microneedle patch. Repeat the evacuation step to complete the application operation, so that the microneedle patch is applied to the skin surface without bubbles.
[0028] The present invention discloses a microneedle application device and a microneedle patch packaging box thereof. The microneedle application device includes a housing, a semi-closed cavity enclosed by the housing, a pressure block disposed in the semi-closed cavity, and an air extraction assembly; the fixed end of the pressure block extends into the semi-closed cavity and is fixedly connected to the top of the semi-closed cavity, and the free end of the pressure block is flush with the open end of the semi-closed cavity; when the microneedle application device works, the open end of the semi-closed cavity fits against the skin to form a sealed cavity, surrounding the microneedle patch attached to the skin therein, the free end of the pressure block presses at least on the microneedle array area of the microneedle patch, and the air extraction assembly provides negative pressure for the sealed cavity. The microneedle patch packaging box includes a groove-shaped storage part for storing the microneedle patch, a release paper for fixing the microneedle patch, and a sealing cover for closing the storage part; the release paper is generally annular, the outer edge of the release paper is fixed on the outer edge of the storage part, and the inner edge of the release paper is detachably adhered to the hydrocolloid edge of the microneedle patch to suspend and fix the tip area of the microneedle patch facing the groove in the storage part; when the microneedle patch packaging box is used for the microneedle application device, the open end of the semi-closed cavity fits against the back of the microneedle patch, and under the negative pressure provided by the air extraction assembly, it drives the microneedle patch to leave the storage part while peeling off the release paper.
[0029] The present invention discloses a microneedle application device and a microneedle patch packaging box thereof. The microneedle application device solves the problems that it is difficult for the microneedle array to penetrate the skin and the microneedle patch does not fit stably with the skin during the application process of the microneedle patch, and realizes bubble-free application of the microneedle patch on the skin surface; when the microneedle patch packaging box is used for the microneedle application device, the user clamps the microneedle patch through the mechanical claw of the microneedle application device, and there is no direct contact with the microneedle patch during the application process, which not only realizes aseptic operation, but also avoids damage or contamination of the microneedle array due to improper handling, affecting the dissolution effect of the microneedle array after the microneedle patch is applied. BRIEF DESCRIPTION OF THE DRAWINGS
[0030] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required for description in the embodiments. Obviously, the following drawings are some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.
[0031] Figure 1 It is a three-dimensional perspective view of the microneedle application device provided by the embodiment of the present invention.
[0032] Figure 2 It is an exploded view of the microneedle application device provided by the embodiment of the present invention.
[0033] Figure 3 It is a full cross-sectional view of the left view of the microneedle application device provided by the embodiment of the present invention.
[0034] Figure 4 It is a full cross-sectional view of the front view of the microneedle application device provided by the embodiment of the present invention.
[0035] Figure 5 It is the top view of the microneedle application device provided by the embodiment of the present invention.
[0036] Figure 6 It is a schematic diagram of the microneedle patch packaging box for the microneedle application device provided by the embodiment of the present invention. Reference numerals
[0037] 1 - Outer shell; 2 - Semi-closed cavity; 21 - Mechanical claw; 22 - Pressure block; 221 - Boss; 222 - Flange; 23 - Thin spring; 24 - Bolt; 31 - Pushing rod; 32 - Movable rod; 33 - Sleeve; 34 - Limiting ring; 35 - Buffer block; 36 - Pushing plate; 37 - Movable block; 38 - Thick spring; 39 - Locking member; 40 - Pressing member; 41 - Air extraction hole; 42 - Exhaust port; 43 - Button; 44 - Switch; 45 - Signal lamp; 5 - Battery; 51 - Circuit board; 6 - Air extraction assembly; 7 - Microneedle patch packaging box; 71 - Storage part; 72 - Gripping groove. Detailed implementation manners
[0038] In order to make the technical problems, technical solutions and beneficial effects solved by the present invention more clearly understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.
[0039] It should be understood that when used in this specification and the appended claims, the terms "comprises" and "comprising" indicate the presence of the described features, wholes, steps, operations, elements and / or components, but do not preclude the presence or addition of one or more other features, wholes, steps, operations, elements, components and / or their combinations.
[0040] It should also be understood that the terms used in the specification of the present invention are merely for the purpose of describing specific embodiments and are not intended to limit the present invention. As used in the specification of the present invention and the appended claims, unless the context clearly indicates otherwise, the singular forms "a", "an" and "the" are intended to include the plural forms; unless otherwise specified, the meaning of "plural" is two or more. It should be further understood that the term "and / or" used in the specification of the present invention and the appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations. In the description of the present invention, the numerical ranges include the present numbers. It should be understood that the terms "length", "width", "diameter", "area", "top", "bottom", "top", "bottom", "upper part", "upper part", etc. are based on the orientation or positional relationship shown in the drawings and should not be construed as limiting the present invention.
[0041] As shown in the attached Figure 1 of the specification, the microneedle application device includes a housing 1, a semi-closed cavity 2 enclosed by the housing 1, a pressure block 22 arranged in the semi-closed cavity 2, an air extraction assembly 6, at least two mechanical claws 21 and a movable assembly. The microneedle application device has an "L"-shaped structure. The housing 1 and the semi-closed cavity 2 are fixed by bolts 24, and a sealing ring is provided at the bolts 24 to improve the sealing performance of the semi-closed cavity 2.
[0042] As shown in the attached Figures 2 - 4 of the specification, the fixed end of the pressure block 22 extends into the semi-closed cavity 2 and is fixedly connected to the top of the semi-closed cavity 2. The free end of the pressure block 22 is flush with the open end of the semi-closed cavity 2. A flange 222 is provided on the side of the pressure block 22 near the free end, and a boss 221 is arranged on the free end surface of the pressure block 22. The flange 222 divides the semi-closed cavity 2 into a mutually communicating inner cavity and an outer cavity. The inner cavity is arranged on the side close to the fixed end of the pressure block 22, and the outer cavity is arranged on the side close to the free end of the pressure block 22.
[0043] The mechanical claws 21 are arranged in the semi-closed cavity 2 around the free end of the pressure block 22. The arm parts of the mechanical claws 21 extend into the interior of the semi-closed cavity 2 through the gap between the flange 222 and the inner wall of the housing 1 and are connected to the movable assembly. When the claw parts of the mechanical claws 21 retract, they are limited by the flange 222. The mechanical claws 21 are L-shaped. When the mechanical claws 21 extend out of the semi-closed cavity 2, the arm parts of the mechanical claws 21 open at an angle of 0-45° to clamp the microneedle patch.
[0044] The movable components include a push rod 31, a movable rod 32 connecting the mechanical claw 21, a limit ring 34 and a buffer block 35 fixed to the top of the movable rod 32, and a locking member 39 provided at the top of the push rod 31. The limit ring 34 and the buffer block 35 are made of rubber. The push rod 31 and the movable rod 32 are connected by a linkage member. The linkage member includes a movable block 37 provided on the movable rod 32 and a push plate 36 provided at the bottom of the push rod 31. The movable block 37 is fixedly connected to the push plate 36. The bottom end of the locking member 39 is correspondingly arranged with the top end of the push rod 31. A sleeve 33 is provided on the outside thereof. The guide groove on the locking member 39 corresponds to the guide rail on the sleeve 33. A pressing member 40 is provided at the top of the locking member 39. The engaging teeth at the bottom end of the pressing member 40 correspond to the protrusions on the side wall of the locking member 39. For the convenience of the user, the top of the pressing member 40 extends out of the sleeve 33 and is provided with a button 43.
[0045] A thin spring 23 and a thick spring 38 provided below the push plate 36 are arranged in the semi-closed cavity 2. One end of the thick spring 38 is connected to the push plate 36, and the other end abuts against the bottom of the housing 1. The thin spring 23 is sleeved on the pressure block 22. One end thereof is connected to the mechanical claw 21, and the other end is connected to the top of the semi-closed cavity 2. The air extraction assembly 6 includes a vacuum source and an air extraction pipe. One end of the air extraction pipe is connected to the air extraction hole 41 at the top of the semi-closed cavity 2, and the other end is connected to the vacuum source. The air extraction pipe is a flexible pipe that is convenient to place inside the housing. An exhaust port 42 is also provided on the vacuum source.
[0046] When the microneedle application device works, the open end of the semi-closed cavity 2 fits against the skin to form a sealed cavity, surrounding the microneedle patch attached to the skin. The boss 221 on the free end face of the pressure block 22 is at least pressed on the microneedle array area of the microneedle patch. The air extraction assembly 6 provides negative pressure for the sealed cavity. The skin covered at the bottom of the semi-closed cavity 2 will be sucked up and deformed. During this process, the microneedle array penetrates into the skin, and the edge of the skin is pressed tightly against the microneedle patch.
[0047] As shown in the attached Figure 5 description, the microneedle application device further includes a battery 5 and a circuit board 51 electrically connected to the air extraction assembly 6, a charging port, and a signal lamp 45. The charging port (not shown in the figure) is provided on the side of the housing 1. There is a switch 44 on the circuit board 51 for controlling the start and stop of the air extraction assembly 6. The signal lamp 45 is provided on the top of the housing 1, specifically three small lamps, which are respectively used to display the operating state of the air extraction assembly 6 (the left signal lamp 45 flashes), the charging state of the battery 5 (the middle signal lamp 45 flashes), and the full charge state of the battery 5 (the right signal lamp 45 flashes).
[0048] As shown in the attached Figure 6As shown in the figure, the micro-needle patch packaging box 7 includes a groove-shaped storage part 71 for storing the micro-needle patch, a release paper for fixing the micro-needle patch, and a sealing cover for closing the storage part 71. The outer edge of the annular release paper is fixed on the outer edge of the storage part 71, and the inner edge is separably adhered to the hydrocolloid edge of the micro-needle patch, so as to suspend and fix the tip area of the micro-needle patch facing the groove in the storage part 71. When the micro-needle application device works, the mechanical claw 21 extends into the grasping groove 72 of the micro-needle patch packaging box 7 to clamp the hydrocolloid edge of the micro-needle patch, take out the micro-needle patch and leave the release paper adhered to the micro-needle patch in the micro-needle patch packaging box 7. Example 1
[0049] When the user first applies the micro-needle patch on the skin surface and then uses the micro-needle application device, the usage steps of the micro-needle application device are as follows: (1) Apply the micro-needle patch on the skin surface. The bottom of the semi-closed cavity 2 of the micro-needle application device fits the skin surface so that the boss 221 of the pressure block 22 corresponds to the micro-needle array of the micro-needle patch. The open end of the semi-closed cavity 2 and the skin surround the micro-needle patch to form a seal. (2) Press the switch 44 to start the vacuum source to evacuate the semi-closed cavity 2. When a negative pressure is formed in the semi-closed cavity 2, the skin is sucked up and deformed to assist the micro-needle array to pierce the skin, and the hydrocolloid at the edge of the micro-needle patch adheres tightly to the skin surface. (3) Press the switch 44 again to turn off the vacuum source, and remove the micro-needle application device. The micro-needle patch is applied to the skin surface without bubbles. Example 2
[0050] When the user uses the micro-needle application device to pick up the micro-needle patch, manually remove the release paper and apply it, the usage steps of the micro-needle application device are as follows: (1) Press the button 43 to make the claw part of the mechanical claw 21 extend out of the open end of the semi-closed cavity 2 and open to pick up the micro-needle patch. (2) Press the button 43 again to make the claw part of the mechanical claw 21 clamp the micro-needle patch and retract into the semi-closed cavity 2. (3) Manually remove the release paper on the micro-needle patch, and fit the bottom of the semi-closed cavity 2 to the skin surface. The open end of the semi-closed cavity 2 and the skin surround the micro-needle patch to form a seal. (4) Press the switch 44 to start the vacuum source to evacuate the semi-closed cavity 2. When a negative pressure is formed in the semi-closed cavity 2, the skin is sucked up and deformed to assist the micro-needle array to pierce the skin, and the hydrocolloid at the edge of the micro-needle patch adheres tightly to the skin surface. (5) Press the switch 44 again to turn off the vacuum source, press the button 43, and remove the micro-needle application device so that the mechanical claw 21 releases the micro-needle patch under the action of elastic force and extends out of the open end of the semi-closed cavity 2. The micro-needle patch is applied to the skin surface without bubbles. Example 3
[0051] When the user uses the microneedle application device to pick up the microneedle patch in the sterile operation of applying the microneedle patch, the usage steps of the microneedle application device are as follows: (1) Tear open the sealing cover of the microneedle patch packaging box 7, press the button 43, so that the claw part of the mechanical claw 21 extends out of the semi-closed cavity 2 and correspondingly extends into the grasping groove 72 of the microneedle patch packaging box 7; (2) Press the button 43 again to make the mechanical claw 21 clamp the hydrocolloid edge of the microneedle patch and retract into the semi-closed cavity 2. Since the release paper is fixed on the outer edge of the storage part 71, the microneedle patch is peeled off from the release paper during the retraction process of the mechanical claw 21 taking out the microneedle patch; (3) Place the microneedle application device on the skin surface, make the semi-closed cavity 2 fit the skin to surround the microneedle patch to form a sealed cavity, press the switch 44 to start the vacuum source to evacuate the semi-closed cavity 2. When a negative pressure is formed in the semi-closed cavity 2, the skin is sucked up and deformed to assist the microneedle array to pierce the skin, and the hydrocolloid at the edge of the microneedle patch is closely attached to the skin surface. Press the switch 44 again to turn off the vacuum source; (4) Press the button 43, move the microneedle application device away to make the mechanical claw 21 release the microneedle patch under the action of elastic force, realizing sterile application, and the microneedle patch is applied to the skin surface without bubbles. Example 4
[0052] When the user uses the microneedle application device to pick up the microneedle patch in the sterile operation of applying the microneedle patch, the usage steps of the microneedle application device are as follows: (1) Press the button 43 to make the mechanical claw 21 extend into the packaging box where the microneedle patch is placed, and adjust the arm of the mechanical claw 21 to open to an angle that can clamp the microneedle patch; (2) Press the switch 44 to start the vacuum source, then press the button 43 to make the mechanical claw 21 clamp the hydrocolloid edge of the microneedle patch. When the mechanical claw 21 retracts into the semi-closed cavity 2, it drives the microneedle patch to leave the packaging box and peel off the release paper under the negative pressure provided by the air extraction component; (3) Place the microneedle application device on the skin surface, make the open end of the semi-closed cavity 2 fit the skin to surround the microneedle patch to form a sealed cavity, and continue to evacuate. When a negative pressure is formed in the semi-closed cavity 2, the skin is sucked up and deformed to assist the microneedle array to pierce the skin, and the hydrocolloid at the edge of the microneedle patch is closely attached to the skin surface. Press the switch 44 to turn off the vacuum source; (4) Press the button 43, move the microneedle application device away to make the mechanical claw 21 release the microneedle patch under the action of elastic force, realizing sterile application, and the microneedle patch is applied to the skin surface without bubbles.
[0053] As described above, it is only the specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims
1. A microneedle patch device, characterized in that: It comprises a shell, a semi-enclosed cavity enclosed by the shell, a pressure block and an air extraction component arranged in the semi-enclosed cavity; The fixed end of the pressure block extends into the semi-enclosed cavity and is fixedly connected to the top of the semi-enclosed cavity, and the free end of the pressure block is flush with the open end of the semi-enclosed cavity; When the microneedle patch device is working, the open end of the semi-enclosed cavity adheres to the skin to form a sealed cavity, enclosing the microneedle patch attached to the skin, the free end of the pressure block is pressed at least on the microneedle array area of the microneedle patch, and the vacuum assembly provides negative pressure for the sealed cavity.
2. The microneedle applicator according to claim 1, characterized in that: The side of the pressure block is provided with a flange near the free end, and the free end surface of the pressure block is provided with a boss. When the microneedle patch device is working, the boss is at least pressed on the microneedle array area of the microneedle patch.
3. The microneedle applicator according to claim 2, characterized in that: It also includes at least two mechanical claws and a movable component. The mechanical claws are arranged in the semi-enclosed cavity around the free end of the pressure block. When the microneedle patch device is working, the mechanical claws are driven by the movable component to extend and retract into the semi-enclosed cavity to reciprocate to clamp or release the microneedle patch.
4. The microneedle applicator according to claim 3, characterized in that: The arm of the mechanical claw passes through the gap between the flange and the inner wall of the shell and extends into the semi-enclosed cavity to be connected with the movable component. When the claw of the mechanical claw is retracted, it is limited by the flange.
5. The microneedle applicator according to claim 3, characterized in that: The movable component includes a pushing rod, a movable rod connected to the mechanical claw, and a linkage member connecting the pushing rod and the movable rod. The movable component is configured so that when the pushing rod is repeatedly pressed, the movable rod is driven by the linkage member to reciprocate.
6. The microneedle applicator according to claim 5, characterized in that: The mechanical claw is L-shaped. After the mechanical claw extends out of the semi-enclosed cavity, its arm is tilted 0-45° to open and clamp the microneedle patch.
7. The microneedle applicator according to claim 5, characterized in that: It also includes a thin spring arranged in the semi-enclosed cavity and a thick spring arranged below the linkage member, and the thin spring and the thick spring are used to control the mechanical claw to extend out of the opening end of the semi-enclosed cavity and retract into the semi-enclosed cavity.
8. The microneedle applicator according to claim 3, characterized in that: The vacuum assembly comprises a vacuum source and a vacuum pipe, one end of the vacuum pipe is connected to the vacuum source, and the other end of the vacuum pipe is connected to the semi-enclosed cavity.
9. A microneedle patch packaging box of the microneedle patch device according to any one of claims 1 to 8, characterized in that: The invention comprises a groove-shaped storage part for storing a microneedle patch, a release paper for fixing the microneedle patch, and a sealing cover for closing the storage part; the release paper is roughly annular, the outer edge of the release paper is fixed on the outer edge of the storage part, and the inner edge of the release paper is detachably bonded to the hydrocolloid edge of the microneedle patch, so that the needle tip area of the microneedle patch is suspended in the storage part facing the groove; When the microneedle patch packaging box is used in a microneedle patch device, the open end of the semi-enclosed cavity is attached to the back of the microneedle patch, and the negative pressure provided by the vacuum assembly drives the microneedle patch to leave the storage part while peeling off the release paper.
10. The microneedle patch packaging box according to claim 9, characterized in that: The outer edge of the storage part is provided with a grasping groove at a position corresponding to the mechanical claw of the microneedle applicator, and a cutout is provided at a corresponding position of the release paper; When the microneedle patch packaging box is used in a microneedle patch device, the mechanical claw extends out of the semi-enclosed cavity and into the grasping groove, and when retracting, it cooperates with the pressure block to clamp the hydrocolloid edge of the microneedle patch, and peels off the release paper while driving the microneedle patch to leave the storage part.