Single imaging animal fixing device, multi-imaging animal fixing device and animal cabin

Abstract

The embodiment of the invention discloses a single imaging animal fixing device, a multi-imaging animal fixing device and an animal cabin. The single imaging animal fixing device comprises a tray for accommodating a single imaging animal, and the tray is provided with a fixing part for fixing each part of the imaging animal. Wherein the fixing parts of all the parts of the imaging animal are arranged at the fixing positions on the tray, and standardized positioning of the imaging animal can be achieved. The multi-imaging animal fixing device comprises a plurality of single-imaging animal fixing devices which are connected together, so that a plurality of animals can be scanned at the same time in a standardized positioning manner. The animal cabin comprises single imaging animal fixing devices and / or multi-imaging animal fixing devices, the number of the single imaging animal fixing devices in the animal cabin can be flexibly adjusted according to requirements, and the internal space of the animal cabin can be utilized to the maximum extent.

Description

Technical Field

[0001] The present application relates to the field of animal imaging, and particularly to a single-imaging animal fixing device, a multi-imaging animal fixing device, and an animal cabin. Background Art

[0002] Animal experiments refer to scientific research using animals (such as mice) to obtain new knowledge in aspects such as biology and medicine or to solve specific problems. In some animal experiments, it is necessary to scan and image the animals. To ensure image quality (e.g., reduce motion artifacts), it is necessary to fix the imaging animals. However, the existing imaging animal fixing solutions cannot achieve standardized positioning of the imaging animals and have low placement efficiency. For example, experimenters use tape to fix mice in a random position on a plane, and generally directly fix the animals in the animal cabin, which requires a high standard for the animal cabin itself and cannot meet the usage requirements of animal experiments. The existing animal cabins are basically customized products based on scanning equipment, which cannot meet diverse experimental needs, and the structures of the animal cabins and their animal fixing devices are provided by the manufacturers for adaptation, unable to adapt to the different experimental needs of different users, resulting in low experimental efficiency. Summary of the Invention

[0003] A first aspect of an embodiment of the present specification provides a single-imaging animal fixing device, including a tray for accommodating a single imaging animal. The tray is provided with a head fixing part, a front limb fixing part, and a rear limb fixing part. The head fixing part is used to fix the head of the imaging animal, the front limb fixing part is used to fix the front limbs of the imaging animal, and the rear limb fixing part is used to fix the rear limbs of the imaging animal. The head fixing part, the front limb fixing part, and the rear limb fixing part are all arranged at fixed positions on the tray to fix the positioning of the imaging animal.

[0004] In some embodiments, the front limb fixing part and / or the rear limb fixing part is a groove structure.

[0005] In some embodiments, the front limb fixing part and / or the rear limb fixing part is a hole structure.

[0006] In some embodiments, the outer shape of the tray is consistent with the outer shape of the imaging animal.

[0007] In some embodiments, the tray is further provided with a tail fixing part, and the tail fixing part is used to fix the tail of the imaging animal.

[0008] In some embodiments, the imaging animal is a mouse.

[0009] In some embodiments, the tail fixing part is a groove structure.

[0010] In some embodiments, the tray is further provided with a first marker accommodating portion adjacent to the front limb fixing portion and a second marker accommodating portion adjacent to the hind limb fixing portion. Both the first marker accommodating portion and the second marker accommodating portion are used to accommodate markers, and the markers are visible in the medical images of the imaged animal.

[0011] In some embodiments, the markers are visible in multiple imaging modalities.

[0012] In some embodiments, the medical images include one or more of magnetic resonance images, positron emission tomography images, computed tomography images, and single photon emission computed tomography images.

[0013] In some embodiments, the tray is for being placed in the animal cabin and is detachably connected to the cabin body of the animal cabin.

[0014] The second aspect of the embodiments of this specification provides a multi-imaging animal fixing device, including a plurality of single-imaging animal fixing devices as described in any embodiment of this specification connected together.

[0015] In some embodiments, the single-imaging animal fixing devices in the multi-imaging animal fixing device are arranged in at least two layers. Among them, the single-imaging animal fixing devices in different layers are connected together by a support portion. The support portion includes a first part and a second part arranged opposite to each other. The first part is used to support the head fixing portion in the single-imaging animal fixing device, and the second part is used to support the end opposite to the head fixing portion in the single-imaging animal fixing device.

[0016] In some embodiments, the support portion further includes a third part between the first part and the second part, and the third part abuts against the bottom of the tray of the single-imaging animal fixing device at the bottom layer.

[0017] The third aspect of the embodiments of this specification provides an animal cabin, including: a cabin body; and a single-imaging animal fixing device as described in any embodiment of this specification and / or a multi-imaging animal fixing device as described in any embodiment of this specification.

[0018] The fourth aspect of the embodiments of this specification provides an animal imaging system, including an animal cabin as described in any embodiment of this specification.

[0019] Embodiments of the present specification provide a single-imaging animal fixing device, a multi-imaging animal fixing device, and an animal cabin. The single-imaging animal fixing device includes a tray for accommodating a single imaging animal (e.g., a mouse), and the tray is provided with fixing parts for fixing various parts of the imaging animal (e.g., the head, forelimbs, hind limbs, tail). Among them, the fixing parts of various parts of the imaging animal are all arranged at fixed positions on the tray to fix the positioning of the imaging animal. That is, the single-imaging animal fixing device can achieve the standardized positioning of the imaging animal. The multi-imaging animal fixing device includes a plurality of the single-imaging animal fixing devices connected together, and can enable a plurality of animals (e.g., a plurality of mice) to be scanned simultaneously in a standardized position. The animal cabin includes the single-imaging animal fixing device and / or the multi-imaging animal fixing device, and the number of the single-imaging animal fixing devices in the animal cabin can be flexibly adjusted according to needs, and the internal space of the animal cabin can be maximally utilized. Description of the Drawings

[0020] This application will be further described by way of exemplary embodiments, and these exemplary embodiments will be described in detail through the drawings. These embodiments are not restrictive. In these embodiments, the same numbers represent the same structures, where:

[0021] Figure 1 is a schematic structural diagram of a single-imaging animal fixing device shown according to some embodiments of the present specification;

[0022] Figure 2 is a schematic diagram of a multi-imaging animal fixing device with a double-layer structure shown according to some embodiments of the present specification;

[0023] Figure 3 is a schematic structural diagram of an animal cabin shown according to some embodiments of the present specification.

[0024] Reference numerals in the drawings: 10 - single-imaging animal fixing device; 20 - multi-imaging animal fixing device; 30 - animal cabin; 100 - tray; 110 - head fixing part; 111 - headgear; 112 - dental rod; 120 - forelimb fixing part; 130 - hind limb fixing part; 140 - tail fixing part; 150 - first marker accommodating part; 160 - second marker accommodating part; 210 - first part; 220 - second part; 230 - third part; 300 - cabin body. Detailed Embodiments

[0025] Exemplary embodiments or implementations will be described in detail herein, and examples thereof are shown in the drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The implementations described in the following exemplary embodiments do not represent all implementations consistent with the present application. On the contrary, they are merely examples of devices and methods consistent with some aspects of the present application as detailed in the appended claims.

[0026] The terms used in this application are for the purpose of describing specific embodiments only and are not intended to limit the present application. The singular forms "a", "the", and "said" used in this application and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise.

[0027] It should be understood that the terms "first", "second", and similar terms used in the specification and claims of this application do not denote any order, quantity, or importance, but are only used to distinguish different components. Similarly, terms such as "a" or "one" do not denote a quantity limitation, but rather indicate the presence of at least one. Unless otherwise specified, terms such as "front", "rear", "lower", and / or "upper" are for convenience of description only and are not limited to a particular position or spatial orientation. The terms "comprising" or "including" and similar terms mean that the elements or items appearing before "comprising" or "including" cover the elements or items listed after "comprising" or "including" and their equivalents, and do not exclude other elements or items.

[0028] It should be noted that although the embodiments of this specification mainly use mice (e.g., mice, rats) as examples for illustration, the fixing device provided in the embodiments of this specification can also be applied to the fixation of other imaging animals, especially small mammals, such as guinea pigs, hamsters, bamboo rats, weasels, rabbits, and the like.

[0029] Figure 1 It is a schematic structural diagram of a single imaging animal fixing device shown in some embodiments of this specification.

[0030] As Figure 1 shown, the single imaging animal fixing device 10 includes a tray 100 for accommodating a single imaging animal, and the tray 100 is provided with a head fixing portion 110, a front limb fixing portion 120, a hind limb fixing portion 130, and a tail fixing portion 140.

[0031] The head fixing part 110 is used to fix the head of the imaging animal. In some embodiments, the head fixing part 110 may include a headgear 111 and a dental rod 112. The headgear 111 is a sleeve-like structure for accommodating the head of the imaging animal, and the dental rod 112 is a rod-like structure for fixing the teeth of the imaging animal (such as rodents like mice and rabbits). The dental rod 112 has an opening (such as a circular or other shaped opening) to hook the teeth of the imaging animal (such as rodents like mice and rabbits). In some embodiments, the head fixing part 110 may include ear rods (not shown). The ear rods are rod-like structures. By inserting the ear rods into the ear canals of the imaging animal and abutting against the skull of the imaging animal, the fixation of the head of the imaging animal can be achieved. The head fixing part 110 may include two ear rods, where one ear rod is for inserting into the left ear canal of the imaging animal and the other ear rod is for inserting into the right ear canal of the imaging animal.

[0032] The front limb fixing part 120 is used to fix the front limbs of the imaging animal.

[0033] As Figure 1 shown, the front limb fixing part 120 can be designed as a groove structure. The groove structure provides sufficient operating space, facilitating the operator to fix the front limbs of the imaging animal to the front limb fixing part 120 or remove them from the front limb fixing part 120.

[0034] The front limb fixing part 120 can also be designed as other structures (not shown). For example, the front limb fixing part 120 can also be designed as a hole structure. The hole structure has a cavity that penetrates through the front limb fixing part 120. After passing the front limbs of the imaging animal through the cavity of the front limb fixing part 120, the front limbs of the imaging animal can be effectively fixed under the restriction of the cavity. The hole structure is not only easier to fix the front limbs of the animal, but also does not form pressure on the front limbs of the animal, making the subsequent imaging area easier to distinguish and enabling a better imaging effect.

[0035] The hind limb fixing part 130 is used to fix the hind limbs of the imaging animal.

[0036] As Figure 1 shown, the hind limb fixing part 130 can be designed as a groove structure. The groove structure provides sufficient operating space, facilitating the operator to fix the hind limbs of the imaging animal to the hind limb fixing part 130 or remove them from the hind limb fixing part 130.

[0037] The hind limb fixing part 130 can also be designed into other structures (not shown). For example, the hind limb fixing part 130 can also be designed into a hole structure which has a cavity running through the hind limb fixing part 130. After passing the hind limbs of the imaging animal through the cavity of the hind limb fixing part 130, the hind limbs of the imaging animal can be effectively fixed under the restriction of the cavity. The hole structure not only makes it easier to fix the hind limbs of the animal, but also does not form pressure on the hind limbs of the animal, making the subsequent imaging area easier to distinguish and enabling better imaging effects.

[0038] The animals used in animal experiments are usually quadruped animals. Correspondingly, the tray 100 is provided with two front limb fixing parts 120 and two hind limb fixing parts 130 to fix the four limbs (i.e., two front limbs and two hind limbs) of the imaging animal.

[0039] The tail fixing part 140 is used to fix the tail of the imaging animal. It should be noted that for some imaging animals without tails (such as guinea pigs) or imaging animals with relatively short tails (the influence of tail movement on imaging can be ignored, such as weasels), the tail fixing part 140 can be omitted. For some imaging animals with long tails (such as mice), the tail fixing part 140 is necessary.

[0040] As Figure 1 shown, the tail fixing part 140 can be designed into a groove structure which provides sufficient operating space, facilitating the operator to fix the tail of the imaging animal to the tail fixing part 140 or remove it from the tail fixing part 140.

[0041] The tail fixing part 140 can also be designed into other structures (not shown). For example, the tail fixing part 140 can also be designed into a hole structure (i.e., there is a cavity inside the structure). After passing the tail of the imaging animal through the cavity of the tail fixing part 140, the tail of the imaging animal can be effectively fixed under the restriction of the cavity.

[0042] It is worth noting that in some scenarios, it is necessary to insert an indwelling needle into the tail of the imaging animal. Due to the fixing effect of the tail fixing part 140, the indwelling needle located in the tail of the imaging animal is also fixed. In this way, the indwelling needle can be prevented from failing due to a change in position.

[0043] Referring to Figure 1, when the single-imaging animal fixing device 10 includes a tail fixing part 140, the head fixing part 110, the front limb fixing part 120, the hind limb fixing part 130 and the tail fixing part 140 are all arranged at fixed positions on the tray 100 to fix the positioning of the imaging animal. Of course, when the single-imaging animal fixing device 10 does not include a tail fixing part 140, the head fixing part 110, the front limb fixing part 120 and the hind limb fixing part 130 are all arranged at fixed positions on the tray 100 to fix the positioning of the imaging animal. That is, the single-imaging animal fixing device 10 can achieve the standardized positioning of the imaging animal.

[0044] The advantages of the single-imaging animal fixing device 10 include but are not limited to: (1) It can achieve rapid switching of the sample (imaging animal, such as a mouse) on different scanning devices (such as CT devices, MR devices, PET devices, etc.) without changing the relative position between the sample and the tray, so as to achieve the fusion of multimodal images; (2) It can establish a multimodal image template, and thus establish a multimodal image database.

[0045] In some embodiments, the outer shape of the tray 100 is consistent with the outer shape of the imaging animal. Specifically, the size of the surface of the tray 100 in contact with the imaging animal can be designed according to the body size of the imaging animal. Taking the imaging animal as a mouse as an example, based on mouse ergonomics design, when the mouse is placed in the tray 100, the body of the mouse can better fit the tray 100, which helps to achieve rapid fixation of various parts of the mouse, tail vein injection, positioning and subsequent imaging.

[0046] In some embodiments, on the basis of the single-imaging animal fixing device 10, other auxiliary means can be used to enhance the fixation of the imaging animal. For example, tape can be used to stick the limbs and tail of the mouse to the corresponding fixing parts to prevent the limbs and tail of the mouse from detaching from the corresponding fixing parts during the imaging process.

[0047] In some embodiments, such as Figure 1As shown, the tray 100 is further provided with a first marker accommodating portion 150 adjacent to the front limb fixing portion 120 and a second marker accommodating portion 160 adjacent to the rear limb fixing portion 130. Both the first marker accommodating portion 150 and the second marker accommodating portion 160 are used to accommodate markers (sometimes also referred to as tracers), and the markers can be developed in the medical images of the imaged animals. The marker can be a solid or a liquid. The medical images include one or more of magnetic resonance images, positron emission tomography images, computed tomography images, and single photon emission computed tomography images. In some embodiments, the marker can be developed in multiple imaging modalities. For example, the marker can be developed in CT images and MR images simultaneously. The ability of the marker to be developed in multiple imaging modalities can make image positioning and registration more convenient. In some embodiments, the marker can be accommodated in a specific part in any feasible manner. Taking the liquid marker as an example, the marker can be accommodated in the first marker accommodating portion 150 and the second marker accommodating portion 160 by means such as smearing method, spraying method, injection method, dropping method, filter paper adhesion method, etc. Since the marker can be developed in the medical image, with the help of the first marker accommodating portion 150 and the second marker accommodating portion 160, the fusion accuracy of multi-modal images can be improved, and the pain points in the prior art such as the image fusion accuracy being limited by the mechanical structure movement accuracy and the animal positioning of the imaged animal can be solved. In addition, since the first marker accommodating portion 150 and the second marker accommodating portion 160 are adjacent to the fixing portions of the limbs, it helps to quickly locate the limbs of the imaged animal in the medical image.

[0048] In some embodiments, the tray is used to be placed in the animal chamber and is detachably connected to the chamber body of the animal chamber. For example, threaded connection, snap connection, etc. By first fixing the animal on the tray and then placing the tray in the animal chamber, the needs of high-throughput animal experiments can be met, which is beneficial to improving the experimental efficiency.

[0049] The embodiments of the present specification further provide a multi-imaging animal fixing device, and the multi-imaging animal fixing device includes a plurality (two or more) of single-imaging animal fixing devices 10 connected together. The plurality of single-imaging animal fixing devices 10 can be arranged in one layer or can be arranged in multiple layers (at least two layers). Relying on the multi-imaging animal fixing device, synchronous scanning of multiple imaged animals (for example, multiple mice) can be realized.

[0050] When the plurality of single-imaging animal fixing devices 10 are arranged in at least two layers, the single-imaging animal fixing devices 10 in different layers can be connected together through a support portion. The support portion includes a first part and a second part arranged oppositely, the first part is used to support the head fixing portion 110 in the single-imaging animal fixing device 10, and the second part is used to support the end portion (for example, the tail fixing portion 140) opposite to the head fixing portion 110 in the single-imaging animal fixing device 10.

[0051] In some embodiments, the first part and the single-imaging animal fixing device 10 are connected together by a snap structure (e.g., a card slot or a snap). In some embodiments, the second part and the single-imaging animal fixing device 10 are connected together by a snap structure (e.g., a card slot or a snap).

[0052] Figure 2 is a schematic diagram of a multi-imaging animal fixing device with a double-layer structure shown in some embodiments of this specification. As Figure 2 shown, the multi-imaging animal fixing device 20 includes four single-imaging animal fixing devices 10 connected together by a support part. The four single-imaging animal fixing devices 10 are arranged in two layers, with two single-imaging animal fixing devices 10 in each layer. The support part includes a first part 210 and a second part 220. The first part 210 is used to support four head fixing parts 110. The second part 220 is used to fix four tail fixing parts 140.

[0053] In some embodiments, a first groove is formed at the bottom of the head fixing part 110, and the edge of the first part 210 is embedded in the first groove to achieve the support for the single-imaging animal fixing device 10. In some embodiments, a second groove is formed at the bottom of the tail fixing part 140, and the edge of the second part 220 is embedded in the second groove to achieve the support for the single-imaging animal fixing device 10. In an alternative embodiment, a first groove is formed at the edge of the first part 210, and the head fixing part 110 is embedded in the first groove to obtain the support of the first part 210. Similarly, a second groove is formed at the edge of the second part 220, and the tail fixing part 140 is embedded in the second groove to obtain the support of the second part 220.

[0054] Different combination methods can be achieved through support parts with different structures to meet different usage requirements. For example, referring to Figure 2 , both the first part 210 and the second part 220 only retain the lower half (e.g., omit the upper T-shaped structure) to achieve the combination of two single-imaging animal fixing devices 10 in a single layer. Another example, referring to Figure 2 , when the second layer is changed to have only one single-imaging animal fixing device, it is allowed to design the upper ends of the first part 210 and the second part 220 to be shorter (e.g., simplified from a T-shaped structure to a handle-shaped structure).

[0055] In some embodiments, referring to Figure 2, the supporting part further includes a third part 230 between the first part 210 and the second part 220, and the third part 230 abuts against the bottom of the tray of the bottommost single-imaging animal fixing device 10. That is, the bottom of the supporting part presents as a larger tray for receiving the plurality of single-imaging animal fixing devices 10. Relying on the third part 230, the plurality of single-imaging animal fixing devices 10 can be combined more stably together, and it is beneficial to the overall movement of the multi-imaging animal fixing device 20.

[0056] Figure 3 is a schematic structural diagram of an animal cabin shown according to some embodiments of the present specification. As Figure 3 shown, the animal cabin 30 includes a cabin body 300 and a multi-imaging animal fixing device 20.

[0057] In other embodiments, the animal cabin 30 includes a cabin body 300 and a single-imaging animal fixing device 10. In still other embodiments, the animal cabin 30 includes a cabin body 300, a single-imaging animal fixing device 10, and a multi-imaging animal fixing device 20.

[0058] In some embodiments, the single / multi-imaging animal fixing device is detachably connected to the cabin body 300. By way of example only, the single / multi-imaging animal fixing device can be detachably fixed to the inner wall of the cabin body 300 by means of snap connection.

[0059] The traditional animal cabin has a slot for fixing the imaging animal on the inner wall. On the one hand, the slot cannot fix the imaging animal separately from the animal cabin, and the animal cabin cannot perform experimental preparations (such as fixing the animal to be scanned) on the animal to be scanned during use. Moreover, due to the large volume of the animal cabin, it will occupy more space in the scanning scenario. On the other hand, the slot design of a single animal cabin is fixed, which is not conducive to flexibly supporting various synchronous scanning methods (especially multi-layer synchronous scanning methods). The single-imaging animal fixing device and multi-imaging animal fixing device provided by the embodiments of the present specification separate the centralized storage function and the auxiliary imaging function of the traditional animal cabin, save more space in the scanning scenario and support more synchronous scanning methods (especially multi-layer synchronous scanning methods). In addition, relying on the flexible and variable multi-imaging animal fixing device 20 (especially the multi-imaging animal fixing device 20 with a multi-layer structure), the animal cabin provided by the embodiments of the present specification can centrally store more fixed imaging animals. Moreover, the single / multi-imaging animal fixing device of the present specification itself has a fixing function and a positioning function, and has a simple structure and is easy to manufacture. It can be easily placed in the cabin body of the existing animal cabin, and is not only applicable to various types of animal cabin bodies and scanning devices, but also multiple and / or various different models of single / multi-imaging animal fixing devices can be configured for a set of animal imaging systems to meet different usage requirements of users.

[0060] In some embodiments, an animal chamber 30 includes a plurality of single / multi-imaging animal fixing devices. An animal chamber 30 may be configured with a plurality of single-imaging animal fixing devices, or a plurality of multi-imaging animal fixing devices, or one or more single-imaging animal fixing devices and one or more multi-imaging animal fixing devices simultaneously. Of course, the plurality of single-imaging animal fixing devices / multi-imaging animal fixing devices may all be the same, or partially the same, or all of different models.

[0061] The embodiments of this specification also provide an animal imaging system, and the animal imaging system includes an animal chamber 30. The animal imaging system further includes a scanning device, and the scanning device includes a CT device, an MR device, a PET device, a SPECT device, or a multi-modal scanning device that is a combination thereof (such as a PET-CT device, a PET-MR device, etc.).

[0062] The beneficial effects that the embodiments of this application may bring include but are not limited to: (1) Provide a single-imaging animal fixing device, which can realize the rapid switching of a sample (imaging animal, such as a mouse) on different scanning devices (such as a CT device, an MR device, a PET device, etc.), and without changing the relative position between the sample and the tray, so as to realize the fusion of multi-modal images; (2) Relying on the single-imaging animal fixing device, a multi-modal image template can be established, and thus a multi-modal image database can be established; (3) Provide a multi-imaging animal fixing device, which can realize the synchronous scanning of multiple imaging animals (such as multiple mice); (4) The single-imaging animal fixing device and the multi-imaging animal fixing device separate the centralized storage function and the auxiliary imaging function of the traditional animal chamber, and are more space-saving in the scanning scenario and support more synchronous scanning methods (especially the multi-layer synchronous scanning method); (5) Provide an animal chamber that can centrally store more fixed imaging animals. It should be noted that the beneficial effects that may be produced by different embodiments are different. In different embodiments, the beneficial effects that may be produced may be any one or several of the above combinations, or any other beneficial effects that may be obtained.

[0063] The basic concepts have been described above. Obviously, for those skilled in the art, the above detailed disclosure is only an example and does not constitute a limitation to this application. Although not explicitly stated here, those skilled in the art may make various modifications, improvements, and corrections to this application. Such modifications, improvements, and corrections are proposed in this application, so such modifications, improvements, and corrections still belong to the spirit and scope of the exemplary embodiments of this application.

[0064] Meanwhile, this application uses specific terms to describe the embodiments of this application. For example, "an embodiment", "one embodiment", and / or "some embodiments" mean a certain feature, structure, or characteristic related to at least one embodiment of this application. Therefore, it should be emphasized and noted that "an embodiment" or "one embodiment" or "an alternative embodiment" mentioned twice or more at different positions in this specification does not necessarily refer to the same embodiment. In addition, certain features, structures, or characteristics in one or more embodiments of this application can be appropriately combined.

Claims

1. A single-imaging animal fixation device, characterized in that, Comprising a tray for accommodating a single imaging animal; The tray is provided with a head fixing part, a front limb fixing part and a hind limb fixing part. The head fixing part is used for fixing the head of the imaging animal, the front limb fixing part is used for fixing the front limbs of the imaging animal, and the hind limb fixing part is used for fixing the hind limbs of the imaging animal; The head fixing part, the front limb fixing part and the hind limb fixing part are all arranged at fixed positions on the tray to fix the positioning of the imaging animal.

2. The single-imaging animal fixing device according to claim 1, characterized in that, The front limb fixing part and / or the hind limb fixing part is a groove structure.

3. The single-imaging animal fixation device according to claim 1, wherein The front limb fixing part and / or the hind limb fixing part is a hole structure.

4. The single-imaging animal fixation device according to claim 1, characterized in that, The outer shape of the tray is consistent with the outer shape of the imaging animal.

5. The single-imaging animal fixation device according to claim 1, wherein The tray is further provided with a tail fixing part, and the tail fixing part is used for fixing the tail of the imaging animal.

6. The single-imaging animal fixing device according to claim 5, wherein, The imaging animal is a mouse.

7. The single-imaging animal fixing device according to claim 5, wherein The tail fixing part is a groove structure.

8. The single-imaging animal fixing device according to claim 1, characterized in that, The tray is further provided with a first marker accommodating part adjacent to the front limb fixing part and a second marker accommodating part adjacent to the hind limb fixing part. The first marker accommodating part and the second marker accommodating part are both used for accommodating markers, and the markers are visible in the medical images of the imaging animal.

9. The single imaging animal fixing device according to claim 8, wherein the marker is visible in multiple imaging modalities.

10. The single imaging animal fixing device according to claim 8, wherein the medical images include one or more of magnetic resonance images, positron emission tomography images, computed tomography images, and single photon emission computed tomography images.

11. The single imaging animal fixing device according to claim 1, wherein the tray is used to be placed in an animal cabin and is detachably connected to the cabin body of the animal cabin.

12. A multi-imaging animal fixing device, characterized in that, Comprising a plurality of single imaging animal fixing devices connected together as described in any one of claims 1 to 11.

13. The multi-imaging animal fixing device according to claim 12, characterized in that, The single imaging animal fixing devices in the multi-imaging animal fixing device are arranged in at least two layers. Among them, the single imaging animal fixing devices in different layers are connected together by a support part. The support part includes a first part and a second part arranged oppositely. The first part is used for supporting the head fixing part in the single imaging animal fixing device, and the second part is used for supporting the end opposite to the head fixing part in the single imaging animal fixing device.

14. The multi-imaging animal fixing device according to claim 13, characterized in that, The support part further includes a third part between the first part and the second part, and the third part abuts against the bottom of the tray of the single imaging animal fixing device in the bottom layer.

15. An animal cabin, characterized in that, Comprising: A cabin body; And The single imaging animal fixing device as described in any one of claims 1 to 11 and / or the multi-imaging animal fixing device as described in any one of claims 12 to 14.

16. An animal imaging system, comprising the animal cabin as described in claim 15.

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