Packing dressing

Abstract

The invention discloses a filling dressing, and relates to the technical field of medical dressings, the filling dressing is prepared from composite yarn, the composite yarn is of a double-layer composite structure, the two-layer structure of the composite yarn comprises an inner hydrophilic layer and an outer hydrophobic layer, the composite yarn is formed by wrapping inner hydrophilic fibers with outer hydrophobic fibers, and the outer hydrophobic fibers wrap the inner hydrophilic fibers. The outer hydrophobic layer is made of hydrophobic fiber filaments; the composite yarn formed by weaving the outer-layer hydrophobic fibers and the inner-layer hydrophilic fibers in a matched mode is used, then the composite yarn is woven into the complete dressing to be used by a patient, the woven filling dressing has the good liquid absorption and anti-infection functions due to the matching of different materials of the inner layer and the outer layer, and meanwhile due to the hydrophilicity and hydrophobicity of the inner layer and the outer layer, the anti-infection effect is good. Meanwhile, due to the fact that the dressing is formed by weaving the composite yarn, the integrality is good, the good anti-adhesion performance is achieved, and due to the effect of the inner layer material, the dressing further has the effects of stopping bleeding, inhibiting bacteria and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of medical dressings, and particularly relates to a packing dressing. Background Art

[0002] The so-called packing dressing is a dressing used for packing body cavities such as nasal cavities, vaginas, fistulas, etc. and deep skin wounds, which is significantly different from the field of conventional sheet dressings. The main functions that a packing dressing needs to have include hemostasis, drainage, exudate absorption, debridement, etc. The existing types of packing dressings are mainly cotton-based oil gauze packing drainage strips, alginates, and vaginal antibacterial gels. The cotton-based oil gauze packing drainage strip has a single function and can only play a basic drainage role, without hemostasis and antibacterial functions, and cannot absorb exudate; it is not suitable for bleeding and infected body cavities, such as after nasal surgery. The alginate packing dressing has good exudate absorption ability, but it will gelify after absorbing exudate; after the alginate dressing gels, its mechanical strength will decrease significantly, and it is easy to have residues when removing the dressing from the body cavity, and the residual dressing will contaminate the wound surface and affect the normal healing of the wound. Antibacterial packing dressings such as vaginal antibacterial gels will also kill probiotics while killing bacteria, destroying the microbial balance, resulting in repeated, multiple, and intractable bacterial vaginitis. The present invention prepares a packing dressing with multiple functions of anti-infection, liquid absorption, hemostasis, and anti-adhesion through the simple compounding of yarns, and the antibacterial mechanism of this dressing is completely different from the traditional bactericidal mechanism, without killing probiotics, which is beneficial to maintaining the microecological balance of the wound. Summary of the Invention

[0003] Object of the Invention: The technical problem to be solved by the present invention is to provide a packing dressing, which solves the problem that the existing packing dressings cannot simultaneously have functions such as hemostasis, drainage, bacteriostasis, exudate absorption, and non-adhesion.

[0004] Technical Solution

[0005] To solve the above problems, the technical solution provided by the present invention is as follows:

[0006] A packing dressing, the packing dressing is a fabric, and the packing dressing is prepared by weaving a plurality of composite yarns.

[0007] The composite yarn has a double-layer composite structure. The double-layer structure of the composite yarn is respectively an inner hydrophilic layer and an outer hydrophobic layer. The inner hydrophilic layer is made of hydrophilic fibers, and the outer hydrophobic layer is made of hydrophobic fibers;

[0008] The composite yarn is formed by the hydrophobic fibers of the outer hydrophobic layer located on the outer layer wrapping the hydrophilic fibers of the inner hydrophilic layer located on the inner layer;

[0009] The hydrophobic fibers of the outer hydrophobic layer are made of hydrophobic fiber filaments, and the hydrophilic fibers of the inner hydrophilic layer are made of hydrophilic fiber yarns, and the hydrophilic fiber yarns are hydrophilic fiber filaments or hydrophilic staple fibers.

[0010] Further, the inner hydrophilic fiber filaments have at least one of the following functions: liquid absorption, antibacterial, hemostasis, and anti-adhesion;

[0011] The inner hydrophilic fiber filaments include cotton, chitosan, oxidized cellulose, and collagen fibers.

[0012] Further, the outer hydrophobic fiber filaments are diacetate fiber or triacetate fiber filaments or PMP melt-spun fibers.

[0013] Further, the structure of the composite yarn is that the outer hydrophobic fiber filaments are wound around the inner hydrophilic fiber yarns, and the winding density is 7-15 turns per centimeter of length.

[0014] Further, at least one outer hydrophobic fiber filament and at least one inner hydrophilic fiber yarn are provided.

[0015] Further, the inner hydrophilic fiber material is composed of one or more hydrophilic fiber filaments in contact with each other and uniformly distributed, and forms an integral filament structure in a long strip shape.

[0016] Further, multiple outer hydrophobic fiber filaments are arranged side by side and obliquely rotatably wound around the inner hydrophilic fibers.

[0017] Further, at least two outer fiber filaments are provided, and at least two outer hydrophobic fiber filaments are cross-wound around the integral filament structure formed by the inner hydrophilic fiber filaments.

[0018] Further, both the hydrophobic fiber filaments and the inner hydrophilic fiber filaments are selected to be 32 counts.

[0019] Further, the packing dressing is woven from the composite yarn in a form of weaving, knitting, or knitting.

[0020] Beneficial effects

[0021] Adopting the technical solution provided by the present invention, compared with the prior art, it has the following beneficial effects:

[0022] The packing dressing of the present invention's application is made by using a composite yarn woven with an outer hydrophobic fiber and an inner hydrophilic fiber. Then, the composite yarn is woven into a complete dressing for patients to use. Due to the cooperation of different materials in the inner and outer layers, the woven packing dressing has good liquid absorption and anti-infection functions. At the same time, due to the hydrophilic and hydrophobic properties of the inner and outer layers, it also has the effect of preventing backflow. At the same time, since the dressing is woven from composite yarn, it has good integrity, thus bringing good anti-adhesion performance. And due to the function of the inner layer material, it also has effects such as hemostasis and antibacterial. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram of the yarn structure;

[0024] Figure 2 It is a scanning electron microscope image of the fabric adsorbing blood cells;

[0025] Figure 3 It is a graph of the test results of the anti-adhesion performance of the fabric of the present invention;

[0026] Figure 4 It is a graph of the data of the backflow prevention test effect of the fabric of the present invention and the control fabric;

[0027] Figure 5 It is a schematic diagram of the usage scenario of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0028] Combined with the attached Figures 1-5 A packing dressing, which is a fabric and is applied in the form of a whole piece of fabric. The fabric constituting the packing dressing is made by weaving a number of composite yarns. When in use, multiple composite yarns are woven into a whole piece of fabric, and then the fabric is used as a packing dressing. The packing dressing is woven into a fabric by a number of composite yarns in a weaving, knitting, and braiding manner, preferably weaving. Compared with knitting, the surface of the dressing will be smoother, and it is not easy to produce edges and corners to stimulate the wound surface when packing; compared with braiding, knitting has higher production efficiency.

[0029] The composite yarn forms a complete dressing through weaving, so as to be used by users, and the prepared packing dressing is covered on the wound surface.

[0030] The composite yarn is composed of a double-layer yarn combination, divided into an inner hydrophilic layer and an outer hydrophobic layer. The outer hydrophobic layer wraps the inner hydrophilic layer. The outer hydrophobic layer is made of a hydrophobic fiber material, and the inner hydrophilic layer is made of a hydrophilic fiber material.

[0031] The hydrophobic fiber of the outer hydrophobic layer is a hydrophobic fiber filament, and the hydrophilic fiber of the inner hydrophilic layer is a hydrophilic fiber yarn.

[0032] Since the yarn contains filaments and staple fibers, the outer hydrophobic layer selects filaments, which can avoid the problem that when the outer hydrophobic layer is made of staple fiber spun yarn, the outer hydrophobic layer made of staple fibers will shed staple fibers and contaminate the wound surface; while the inner hydrophilic layer can be made of yarn composed of filaments or staple fibers because it is located inside.

[0033] The hydrophilic fiber material of the inner layer has the properties of liquid absorption, hemostasis, and antibacterial, thus achieving the effect of promoting wound healing. The hydrophilic fiber material of the inner layer is preferably cotton, chitosan, oxidized cellulose, and collagen fiber.

[0034] When chitosan is used as the inner layer fiber material, it has the functions of hemostasis, antibacterial, and promoting wound healing. At the same time, chitosan itself has good biocompatibility and biodegradability. After being absorbed by the human body, it can also regulate the body's acid-base balance and enhance the user's immunity.

[0035] Hemostasis: Chitosan has a hemostatic function and can be used for hemostasis treatment of skin, wounds and other parts.

[0036] Antibacterial: Chitosan has an inhibitory effect on a variety of bacteria and can be used for disinfection and antibacterial treatment in the medical field.

[0037] Promote wound healing: Chitosan can promote wound healing and accelerate tissue repair.

[0038] Biocompatibility and biodegradability: Chitosan has good biocompatibility and biodegradability, can be absorbed by the human body, and will not cause harm to the human body.

[0039] Regulate the body's acid-base balance: Chitosan can increase the blood pH value, which helps to regulate the body's acid-base balance.

[0040] Enhance immunity: Chitosan can enhance the quality and quantity of immune specific somatic cells and has a positive effect on the human immune system.

[0041] When oxidized cellulose is used as the inner layer fiber material, it has the characteristics of good biocompatibility, biodegradability, and non-toxicity. It also has the characteristics of hemostasis, antibacterial, easy absorption, and convenient use.

[0042] Hemostasis: Oxidized cellulose has a good hemostatic effect. It can quickly promote blood coagulation through physical action and effectively control bleeding of small blood vessels. Its hemostatic mechanism is to aggregate platelets in the wound surface blood on the mesh gauze, quickly form a gel-like black substance, and coagulate blood clots, thus achieving the purpose of hemostasis.

[0043] Completely absorbed: Oxidized cellulose can be completely absorbed in the body and has almost no specific reaction to the surrounding tissues.

[0044] Convenient to use: Oxidized cellulose, such as fabric, can easily adhere to the irregular bleeding surface. During use, suture, wrapping, filling, and dressing methods can be applied, and it can be widely used in almost all surgical methods.

[0045] Bactericidal: Oxidized cellulose has a certain bactericidal effect.

[0046] When collagen fibers are used as the inner layer fiber material, they can promote wound regeneration, repair the skin and tissues.

[0047] Filling and repair: Collagen fibers can fill the skin and at the same time promote tissue repair and regeneration.

[0048] Maintaining skin elasticity: The high toughness and tensile resistance of collagen fibers can maintain skin elasticity and firmness, preventing and delaying skin aging.

[0049] Affecting microcirculation: The generation, densification and thickening deposition of collagen fibers will affect the microcirculation function of the human body. Microcirculation disorders may lead to the occurrence of various diseases, so the state of collagen fibers is of great significance to human health.

[0050] When chitosan, oxidized cellulose and collagen fibers are used as the inner layer fiber materials, they all have direct effects such as hemostasis, antibacterial and promoting wound healing, and have significant effects as the inner layer materials of double-layer packing dressings.

[0051] The outer layer fiber material is a hydrophobic fiber material, which is used to contact the bacteria on the wound surface and adsorb the bacteria on the wound surface. Preferably, it is diacetate fiber, that is, diacetate fiber filaments. Diacetate fiber filaments are often used in the medical field for making dressings and drug carriers. The diacetate fiber filaments can be replaced by hydrophobic fiber materials that meet medical standards including but not limited to triacetate fiber filaments, PMP melt-spun fibers, etc.

[0052] When the composite yarn is woven, the outer layer fiber material wraps the inner layer fiber material. By winding and coating the outer hydrophobic fiber material on the inner hydrophilic fiber material, a composite yarn is formed that has both a strong bacterial adhesion function to peel bacteria from the wound surface and the function of absorbing the fluid inside the wound surface.

[0053] Then, several composite yarns are made into a complete and usable packing dressing, which can not only adhere to the surface bacteria of the wound surface, but also suck out the deep bacteria of the wound surface through absorbing the exudate of the wound surface to contact with the dressing, so as to achieve the effect of peeling bacteria from the wound surface.

[0054] Since the adhesion of bacteria requires direct contact with the packing dressing, when the packing dressing made of the composite yarn using the above technical solution acts on the wound surface, it can perform the same functions as the composite yarn. It can not only adhere to the surface bacteria, but also suck out the deep-layer bacteria in the wound surface by absorbing the wound exudate and bringing them into contact with the dressing, thereby stripping the bacteria from the wound surface.

[0055] Moreover, the packing dressing made of the composite yarn can also prevent backflow. Since the inner layer is made of hydrophilic fibers, after the hydrophilic fibers absorb the wound exudate, the outer hydrophobic fibers can play a role in blocking the backflow of the exudate. And because the liquid will flow to the side with less liquid content, the exudate has the property of approaching and being stored in the hydrophilic fibers. At the same time, combined with the outer hydrophobic fiber material, the situation of backflow will be greatly reduced.

[0056] Since the diacetate fiber filaments of the outer hydrophobic fibers are not prone to wrinkling and have the properties of moisture absorption and quick drying, when the complete packing dressing covers the wound surface, after the outer hydrophobic fibers come into direct contact with the wound surface, they can directly transfer the wound exudate to the inner hydrophilic fibers. The inner hydrophilic fibers store the exudate inside. At the same time, because the outer hydrophobic fibers themselves are not prone to wrinkling and are in filament structure, during the process of weaving the composite yarn, there will be no messy fiber lines and the integrity is good. Each outer hydrophobic fiber is woven outside the inner layer fibers, with strong integrity. Therefore, the outer hydrophobic fibers will not adhere to the patient's wound surface, and the patient can easily remove the packing dressing without causing secondary damage to the wound surface when removing it.

[0057] Since the inner layer fibers are chitosan, oxidized cellulose and collagen fibers, all of which have the functions of hemostasis, bacteriostasis and promoting wound healing, the packing dressing also has good therapeutic effects.

[0058] Since the packing dressing is woven from composite yarns, and each composite yarn is woven separately from the inner and outer layer fibers, the packing dressing woven from the composite yarns has strong integrity. After the composite yarns are woven into an integrated structure, they are not easy to break and fall off. Therefore, no residues will be left on the wound surface, and the wound surface can be kept in a relatively clean environment.

[0059] The outer hydrophobic fiber material is wound around the inner hydrophilic material, and there are various winding methods. The winding density of the outer hydrophobic fibers wound around the inner hydrophilic fibers is 7 - 15 turns of the outer hydrophobic fibers wound around every 1 cm long inner hydrophilic layer. The specific winding methods include but are not limited to the following several.

[0060] The materials for making the composite yarn are preferably selected as the outer hydrophobic fiber material being diacetate fiber filaments and the inner hydrophilic fiber material being cotton yarn.

[0061] In a preferred embodiment, as Figure 3As shown, the outer hydrophobic fiber material is composed of one or more hydrophobic fiber filaments arranged side by side in contact with each other, and the inner hydrophilic fiber material is composed of one or more hydrophilic fiber filaments in contact with each other and evenly distributed, and as far as possible forms an integral filament structure similar to a cylinder. The outer hydrophobic fiber filaments arranged side by side are wound around the inner fiber filament structure. The winding method of the outer hydrophobic fiber material is rotational inclined winding, that is, spiral winding. The wide surface of the outer hydrophobic fiber formed by arranging side by side is in direct contact with the inner hydrophilic fiber filaments. At the same time, the bottom edge of the first winding is connected to the top edge of the second winding, so as to wind the outer hydrophobic fiber filaments around the inner hydrophilic fiber filaments, so as to meet the requirement of the outer hydrophobic fiber material wrapping the inner hydrophilic fiber material.

[0062] Among them, the outer hydrophobic fiber material is wound around the inner hydrophilic fiber material with one hydrophobic fiber filament. The inner hydrophilic fiber is composed of one or more yarns in parallel contact. One outer hydrophobic fiber is inclined to wind around the inner hydrophilic fiber. The outer hydrophobic fiber in the winding state is an inclined winding structure with the side in full contact with the inner hydrophilic fiber. At this time, the outer hydrophobic fiber can completely cover the inner hydrophilic fiber, that is, a monofilament wrapped fabric.

[0063] In another embodiment, as Figure 4 shown, the inner hydrophilic fiber material is composed of one or more hydrophilic fiber filaments in contact with each other and evenly distributed, and as far as possible forms an integral filament structure similar to a cylinder. The outer hydrophobic fiber material is cross-wound around the integral filament structure formed by the inner hydrophilic fiber with at least two filaments, so as to wind the outer hydrophobic fiber filaments around the inner hydrophilic fiber filaments, so as to meet the requirement of the outer hydrophobic fiber material wrapping the inner hydrophilic fiber material.

[0064] Among them, the outer hydrophobic fiber material uses two hydrophobic fibers to wind around the inner hydrophilic fiber material. The two outer hydrophobic fiber filaments are cross-wound around the inner hydrophilic fiber material. The inner hydrophilic fiber material is composed of one or more inner hydrophilic fibers in parallel contact. The two outer hydrophobic fibers are completely wrapped around the inner hydrophilic fiber by cross-winding, that is, a double-filament wrapped fabric.

[0065] The stuffing dressings formed by the composite yarn fabrics of the above two winding methods have the following functions:

[0066] 1. Liquid absorption and anti-infection: Since the inside is hydrophilic fiber, when the stuffing dressing covers the wound of the patient, it can absorb the body fluid secreted by the patient's wound surface; by absorbing the exudate from the wound surface, the deep bacteria on the wound surface are sucked out and come into contact with the dressing, so as to strip the bacteria from the wound surface, so that the stuffing dressing has anti-infectivity.

[0067] 2. Anti-backflow: The composite yarn has a hydrophobic outer layer and a hydrophilic inner layer structure design, which is beneficial for the rapid absorption of the infiltrated liquid in the cavity and can prevent the infiltrated liquid from backflowing out of the yarn under compression. Under the same test conditions, the simulated backflow rate of the composite yarn is about 20%-25%, and the backflow rate of the all-cotton gauze is about 40%; the backflow volume of the composite yarn is reduced by about 20%-15% compared with that of the all-cotton gauze.

[0068] 3. Anti-adhesion: The anti-adhesion performance refers to the ability of the dressing to adhere to human tissues. Good anti-adhesion means that the dressing is not easy to adhere to the wound tissue and is easy to replace the dressing, and it is not easy to cause secondary damage to the tissue when replacing the dressing. Under the same test environment, the adhesion force of the composite yarn is about 0.7-0.8N, and the adhesion force of the cotton gauze is about 3.0N.

[0069] Although the oil gauze is a recognized dressing with anti-adhesion effect and its adhesion force is about 0.3N, the oil gauze does not have the ability to absorb liquid.

[0070] 4. Hemostasis: This yarn has a certain hemostatic performance, and the coagulation index is about 15%. Its hemostasis mechanism is as follows: the hydrophobic fiber surface adsorbs platelets and red blood cells to activate the coagulation function, and the hemostasis is achieved by the compression effect of the yarn after absorbing liquid and swelling on the bleeding point.

[0071] The packing dressings formed by the composite yarn fabrics in the above two winding methods, after subsequent experimental comparison, such as Figure 4 For the winding method, the liquid infiltration absorption rate and the bacterial adhesion rate of the double-filament coated fabric with two acetate fibers cross-wound on the outer layer are higher than those of the single-filament coated fabric with a single-filament one-way winding method such as Figure 3 Although the liquid infiltration absorption rate and the bacterial adhesion rate of the single-filament coated fabric are lower than those of the double-filament coated fabric, they are all significantly better than the fabric composed of pure hydrophobic fibers.

[0072] The preparation process of the composite yarn is as follows:

[0073] The 32-count diacetate fiber filaments are coated on the 32-count cotton yarn through a wool spinning flower twisting small prototype to obtain the composite yarn.

[0074] When the composite yarn is made by the inclined winding method, the parameters of the equipment are that the upper hollow spindle speed is 0 rpm, the lower hollow spindle speed is 600 rpm, the core wire roller speed is 1 m / min, and the output roller speed is 1.1 m / min.

[0075] When the composite yarn is made by the cross-winding method, the parameters of the equipment are that the upper hollow spindle speed is 600 rpm, the lower hollow spindle speed is 600 rpm, the core wire roller speed is 1 m / min, and the output roller speed is 1.1 m / min.

[0076] The obtained composite yarn is woven into a packing dressing through a handheld flat knitting machine.

[0077] The device is not limited to the wool spinning and twisting small prototype and the handheld flat knitting machine.

[0078] Experimental example

[0079] Select diacetate filament as the outer hydrophobic fiber material and cotton yarn as the inner hydrophilic fiber material.

[0080] The specifications of both the diacetate filament and the cotton yarn are selected as 32 counts.

[0081] Put the 32-count diacetate filament and 32-count cotton yarn into the knitting machine to produce composite yarns and stuffing dressings.

[0082] The preferred composite knitting machine is: the wool spinning and twisting small prototype; the preferred knitting machine for stuffing dressings is: the handheld flat knitting machine.

[0083] Directly set the composite knitting machine, and use the inclined winding method and the cross winding method to produce composite yarns respectively, so as to obtain the single-filament coated fabric and the double-filament coated fabric of the present technical solution. The single-filament coated fabric and the double-filament coated fabric are used as experimental examples respectively. At the same time, since there are multiple materials available for the inner hydrophilic layer of the single-filament coated fabric and the double-filament coated fabric, the experimental examples can be correspondingly changed according to the different materials used as the inner hydrophilic layer, and just indicate it during the experiment.

[0084] Comparative example 1

[0085] In the prior art, a new idea of separating bacteria from the wound surface when changing the dressing is realized by enhancing the binding force between bacteria and the dressing, and it is verified that the PMP fiber fabric obtained by electrospinning and melt spinning has strong bacterial adhesion, and the PMP fiber fabric obtained by melt spinning is the closest to the fabric structure of the present invention. Therefore, PMP melt spinning is selected to weave into the stuffing dressing.

[0086] Comparative example 2

[0087] Directly select the stuffing dressing made of acetate fiber fabric as Comparative example 2, so as to observe the changes in the liquid seepage absorption rate and bacterial adhesion of the composite yarns of the single-filament coated fabric and the double-filament coated fabric in the experimental examples compared with the acetate fiber fabric.

[0088] 1. Liquid seepage absorption rate experiment

[0089] The experimental method is as follows: Prepare the materials for the experiment. Place the prepared simulated wound exudate in a round petri dish. Cover the packing dressings of Experimental Example 1 and Experimental Example 2, and Comparative Example 1 and Comparative Example 2 on the experimental apparatus with the same simulated wound conditions for 30 minutes to allow the packing dressings to fully absorb the liquid. Record the weight before contacting the exudate as m1 and the weight after contacting the exudate as m2. The calculation method for the absorption rate of wound exudate is: liquid absorption amount = (m2 - m1) / m1.

[0090] The experimental results are as follows:

[0091]

[0092] It can be seen from the experimental results that the melt-spun fabrics of cellulose acetate and PMP are hydrophobic and have no liquid absorption property. Cotton yarn has good hydrophilicity, and the liquid absorption rate can reach up to more than 8 times its own weight. The overall liquid absorption rate of the composite yarn is lower than that of the pure cotton fabric because the composite yarn contains both hydrophilic components and hydrophobic components. At the same time, the winding of the outer hydrophobic cellulose acetate restricts the liquid absorption expansion of the core cotton yarn, resulting in the liquid absorption rate of the composite yarn being about 4 times its own weight. The liquid absorption rate of the double-filament covered yarn fabric is slightly higher than that of the single-filament covered composite yarn fabric, probably because there are mutual overlaps of hydrophobic filaments in the double-filament covered yarn fabric, resulting in more void structures, providing more liquid absorption expansion space for the cotton yarn in the core of the double-filament covered yarn.

[0093] 2. Bacterial adhesion performance experiment

[0094] The experimental method is as follows: Cut the sample to be tested into a 3 cm × 3 cm sample and place it in a 50 mL centrifuge tube for standby. Take the Staphylococcus aureus bacterial liquid in the logarithmic growth phase and put it into the centrifuge tube. Centrifuge at 8000 r / min for 5 min using a high-speed centrifuge. After centrifugally washing 3 times with sterile water, pour off the supernatant, then add bacterial culture medium, and measure the absorbance value at 600 nm using an ultraviolet spectrophotometer. Dilute it into a bacterial suspension with OD600 = 0.1. Add 5 mL of the bacterial suspension to each 50 mL centrifuge tube containing the sample to be tested, then add 20 mL of culture medium, seal it, and place it in a 37 °C biochemical incubator for static culture. After culturing for 12 h, take out the sample film with adhered bacteria, wash it 3 times with sterile water, put it into a new 10 mL centrifuge tube, add 2 mL of 10% CCK-8 solution (diluted with PBS), place this centrifuge tube in the biochemical incubator for incubation for 4 h. After taking it out, transfer the upper layer solution to a 96-well plate, and measure the absorbance value of the solution at 450 nm using an enzyme-labeling instrument. The level of the absorbance value can reflect the number of adhered bacteria. The higher the absorbance, the more bacteria are adhered. Set 5 parallel samples in each group, and use SPSS 16.0 to calculate the mean ± standard deviation of the optical density measured in each group.

[0095] The experimental results are as follows:

[0096]

[0097] From the test results, it can be seen that the number of bacteria adhered to the coated fabric formed by the composite yarn is significantly better than that of the single-component fabrics of acetate fiber and PMP. Moreover, for any material selected for the inner layer fibers of the inner hydrophilic layer, its bacteria adhesion is better than that of the single-component fabrics of acetate fiber and PMP. And among the coated fabrics formed by the composite yarn, the number of bacteria adhered to chitosan is the largest. Because chitosan is positively charged, in addition to adhering bacteria through hydrophobic interaction, the charge interaction also plays a certain role. At the same time, it can also be seen that the double-filament coated yarn fabric has a higher number of bacteria adhered than the single-filament coated yarn fabric.

[0098] 3. Anti-adhesion performance experiment:

[0099] Experimental method:

[0100] The potential adhesiveness of five non-woven fabrics as wound dressings was tested with reference to the method of YY / T 1477.4-2017. The method is to use thrombin to coagulate animal fibrinogen into fibrin clots, and use the fibrin clots as a damaged wound tissue model. The dressing to be tested is placed on the wound model for a certain period of time and a certain pressure is applied, and then the potential adhesion performance of the dressing to be tested on the wound is evaluated by testing the peeling force when the dressing to be tested is peeled off from the wound model.

[0101] (1) Preparation of the wound model (fibrin clot).

[0102] Weigh 0.9 g of sodium chloride and add it to a beaker containing 100 mL of deionized water to prepare a sodium chloride solution. Then add 30,000 units of thrombin to it and dissolve it fully to obtain a thrombin solution for standby. Weigh 10 g of bovine serum albumin and add it to a beaker containing 1000 mL of sterile PBS to dissolve and prepare a BSA-PBS solution. Then weigh 30 g of fibrinogen and stir it fully to dissolve to obtain a fibrinogen solution. Use a pipette to dispense the fibrinogen solution into disposable 6-well cell culture plates, 10 mL per well. Then add 1 mL of thrombin solution to each well and stir it quickly to mix it evenly. First, place the well plate containing the fibrin clot in an incubator at (37 ± 2) °C for 1 h, and then take it out and cool it at room temperature for 2 h to make it solidify and form for standby.

[0103] (2) Dressing adhesion test.

[0104] Cut the dressing to be tested into pieces of 5 cm × 10 cm according to the fibrin clot size. Then, sandwich the fibrin clot between two pieces of the dressing to be tested, and apply a 100 g weight on it. Place it in an incubator (temperature: 37 °C, humidity: 85%) to allow the dressing to be tested to adhere to the fibrin clot for 24 h. After adhesion, remove the weight, take out the dressing combination to be tested and let it stand for 2 h to cool to room temperature. Then, use a universal tensile testing machine to test the peeling force when the dressing to be tested is peeled off from the fibrin clot. The peeling force can be used to evaluate the potential adhesiveness between the dressing to be tested and the wound surface.

[0105] And the results of the potential adhesiveness test of five non-woven fabrics as wound dressings are as Figure 3 shown, where Adhesion force (N) represents the adhesion force. The lower the adhesion force, the better the anti-adhesion performance.

[0106] It can be seen from the test results that oil gauze is the most commonly used anti-adhesion dressing in the market. The test results show that the anti-adhesion effect of this product is slightly weaker than that of oil gauze and acetate fiber dressing, and significantly better than that of absorbent cotton and ordinary gauze, with good anti-adhesion effect.

[0107] 4. Backflow effect experiment:

[0108] The experimental method is as follows: Immerse the dressing in the wound exudate simulation liquid until saturated, weigh and record. Place the saturated dressing on the absorbent filter paper, and weigh it after squeezing the dressing with a heavy object for different times. Determine the backflow effect based on the weight loss.

[0109] The experimental results are as Figure 4 shown. The greater the mass loss, the more the originally adsorbed liquid is lost, which means the more liquid exuded from the dressing and the worse the anti-backflow performance.

[0110] It can be seen from the test results that acetate fiber and PMP melt-spun fabrics are not hydrophilic, and can only retain a small amount of liquid in the fabric gaps, with very low liquid absorption performance. Cotton gauze and composite yarn fabrics both have good liquid absorption performance. However, the backflow rate of cotton gauze reaches 44.75%, the backflow rate of double-wrapped yarn is 21.98%, and the backflow rate of single-wrapped yarn fabric is 30.47%. Double-wrapped yarn shows the best anti-backflow effect. The anti-backflow rate of the composite yarn packing dressing is significantly better than that of cotton yarn.

[0111] 5. Coagulation performance experiment:

[0112] Coagulation experiment method: Take 1 ml of whole blood and add it to 10 ml of 0.2 mol / l calcium chloride solution to obtain calcified whole blood.

[0113] Sample group: Take 50 mg of the sample in each group and add it to a 50 ml centrifuge tube, along with 1 ml of calcified whole blood and 20 ml of PBS buffer solution with pH = 7.4 (±0.1).

[0114] Blank control group: 1 ml of calcified whole blood was added to 20 ml of PBS buffer with pH = 7.4 (±0.1).

[0115] After the three groups were separately placed statically in an incubator at 37°C for 10 min, the supernatant was taken and the absorbance at 540 nm was measured in a 96-well plate. The coagulation index calculation formula is: I = [(Ac - As) / Ac] × 100%, where Ac is the absorbance of the blank control and As is the absorbance of the test sample.

[0116] The test results are as follows in the table:

[0117]

[0118] The higher the coagulation index, the more blood cells adsorbed on the fabric, that is, the higher the coagulation performance.

[0119] The test results show that the coagulation rate of the composite coated yarn is higher than that of the single-component yarn fabric; the double-filament coated yarn is better than the single-filament coated yarn; the hemostatic performance is the highest when the core yarn is chitosan and oxidized cellulose, slightly better than the composite yarn fabric with collagen as the core yarn, and significantly better than the composite yarn fabric with cotton yarn as the core yarn.

[0120] 5. Contact angle experiment:

[0121] Experimental method: It can be directly measured, and the smaller the contact angle, the better its hydrophilicity.

[0122] Table 2. Contact angle test results of several different fabrics

[0123]

[0124] Due to the good hydrophilicity of degreased cotton yarn, the liquid shows an almost completely wetted state; the esterification rate of diacetate fiber is about 74% - 92%, with weak hydrophilicity, and the contact angle measured at different sites is between 65 - 75; the PMP melt-spun fabric is a polyolefin material, showing strong hydrophobicity, and the contact angle measurement is between 126 - 135; the surface contact angle of the diacetate fiber filament coated yarn fabric is 111 - 124. This may be because the uneven structure formed by the filament winding during fiber formation plays a role similar to the lotus leaf effect, resulting in a significantly increased contact angle compared to the pure diacetate fiber fabric; for the double-filament coated yarn, the outer diacetate fibers overlap with each other, exposing some highly hydrophilic cotton fabrics, unexpectedly showing a similar effect of guiding moisture, and being able to absorb liquid quickly. Combining the measurement data of the contact angle, the composite yarn fabric with double-filament coating has faster and more excellent liquid absorption performance.

[0125] The above-described embodiments merely represent several implementation manners of the present invention. The description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the patent for the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all fall within the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention shall be subject to the appended claims.

Claims

1. A packing dressing, characterized in that: The packing dressing is a fabric, wherein the packing dressing is woven from a plurality of composite yarns. The composite yarn is a double-layer composite structure, and the double-layer structure of the composite yarn comprises an inner hydrophilic layer and an outer hydrophobic layer, wherein the inner hydrophilic layer is made of hydrophilic fiber, and the outer hydrophobic layer is made of hydrophobic fiber; The composite yarn is formed by the hydrophobic fibers of the outer hydrophobic layer located in the outer layer wrapping the hydrophilic fibers of the inner hydrophilic layer located in the inner layer, The hydrophobic fibers of the outer hydrophobic layer are made of hydrophobic fiber filaments, and the hydrophilic fibers of the inner hydrophilic layer are made of hydrophilic fiber yarns, and the hydrophilic fiber yarns are hydrophilic fiber filaments or hydrophilic fiber staple fibers.

2. A packing dressing according to claim 1, characterized in that: The inner layer of hydrophilic fiber filaments has at least one of the following functions: liquid absorption, antibacterial, hemostasis and anti-adhesion; The inner layer of hydrophilic fiber filaments includes cotton, chitosan, oxidized cellulose and collagen fibers.

3. A packing dressing according to claim 1, characterized in that: The outer layer hydrophobic fiber filaments are diacetate fiber or triacetate fiber filaments or PMP melt-spun fibers.

4. A packing dressing according to claim 1, characterized in that: The structure of the composite yarn is that the outer layer of hydrophobic fiber filaments are wound around the inner layer of hydrophilic fiber yarns, and the winding density is 7-15 turns per centimeter length.

5. A packing dressing according to claim 1, characterized in that: The outer layer hydrophobic fiber filaments and the inner layer hydrophilic fiber yarns are provided as at least one.

6. A packing dressing according to claim 5, characterized in that: The inner layer hydrophilic fiber material is composed of one or more hydrophilic fiber filaments that are in contact with each other and evenly distributed and combined to form a long strip-shaped integral filament structure.

7. A packing dressing according to claim 5, characterized in that: The plurality of outer layer hydrophobic fiber filaments are arranged side by side and are wound around the inner layer hydrophilic fibers in an oblique rotational manner.

8. A packing dressing according to claim 1, characterized in that: The outer layer fiber filaments are arranged in at least two pieces, and the at least two outer layer hydrophobic fiber filaments are cross-wound on the integral filament structure formed by the inner layer hydrophilic fiber filaments.

9. A packing dressing according to claim 1, characterized in that: The hydrophobic fiber filaments and the inner layer hydrophilic fiber filaments are both selected to be 32 counts.

10. A packing dressing according to claim 1, characterized in that: The packing dressing is woven from the composite yarn in the form of weaving, braiding or knitting.

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