A soothing redness-reducing, blue light-protecting, after-sun repairing composition

Abstract

The application discloses a composition for soothing redness, resisting blue light and repairing after sun exposure, and belongs to the field of cosmetic preparations. The composition comprises Dendrobium officinale Kimura et Migo extract, Scutellaria baicalensis Georgi root extract and Acer Rubrum L. extract. The composition provided by the application has the effects of significantly soothing redness, resisting blue light and repairing after sun exposure.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of toiletry formulations, and specifically relates to a soothing, redness-reducing, blue light-resistant and after-sun repairing composition. BACKGROUND

[0002] With the increasing attention to skin health and beauty, there is an increasing demand for skincare products that can effectively solve skin problems. Among many skin problems, skin redness, sensitivity and blue light damage to the skin have become the focus of modern people's attention.

[0003] Skin redness and sensitivity are usually caused by various factors, such as environmental stimuli (air pollution, ultraviolet radiation), endogenous factors, lifestyle, etc. In order to effectively solve these problems, it is urgent to develop skincare products with soothing and redness-reducing functions. For example, CN114469772A provides an anti-inflammatory soothing composition based on targeted redness reduction, which uses a nanocarrier containing glycerides to coat hydroxysafflor yellow A, takes advantage of the good skin penetration of glycerides to carry and penetrate hydroxysafflor yellow A into the skin, improves the problem that hydroxysafflor yellow A is difficult to penetrate the epidermis of the skin, and enables hydroxysafflor yellow A to reach the site of inflammation, achieving the effects of targeted anti-inflammatory and soothing redness reduction. At the same time, this coating structure can also achieve sustained release of active ingredients, prolong the action time and improve the effect.

[0004] On the other hand, with the widespread use of electronic devices, the damage of blue light to the skin has also attracted people's attention. Blue light has strong penetration and wide sources, belongs to visible light with longer wavelength and stronger energy, can penetrate the skin surface, weaken the skin barrier, damage the extracellular matrix, induce oxidative stress to cause excessive free radical production, and thus cause skin darkening, aging, dullness, redness and dryness, etc. In order to resist the damage of blue light to the skin, it has become a trend to develop skincare products with anti-blue light function. Some plant extracts, such as hu zhi zi extract, can enhance the defense system of cells and effectively protect cells from blue light invasion; ingredients such as niacinamide can inhibit oxidative damage caused by blue light and reduce protein carbonylation, thereby protecting the skin from blue light damage.

[0005] In addition, after-sun repair is also an important part of skin care. After ultraviolet radiation, the skin is prone to damage such as redness, peeling, etc., which needs to be repaired in time. Some plant ingredients with soothing and repairing effects, such as horse chestnut, calendula, asiatic pennywort extract, can effectively soothe sun-damaged skin and promote the self-repair of the skin.

[0006] In summary, it is of great significance to develop a composition that can simultaneously achieve soothing, redness-reducing, blue light-resistant and after-sun repairing functions to meet the diversified needs of modern people for skin care. SUMMARY

[0007] The present application provides a soothing red repair, blue light resistance, after-sun repair composition, which has the effects of soothing red repair, blue light resistance and after-sun repair through the compounding of dendrobium officinale extract, scutellaria baicalensis root extract and acer spicatum extract.

[0008] In order to achieve the above-mentioned purpose, the present application adopts the following technical solutions:

[0009] In a first aspect, the present application provides an after-sun repair composition, which comprises the following mass parts of raw materials:

[0010] Dendrobium officinale extract: 1-6 parts;

[0011] Scutellaria baicalensis root extract: 0.1-1 part;

[0012] Acer spicatum extract: 0.1-2 parts.

[0013] Preferably, the composition comprises the following mass parts of raw materials:

[0014] Dendrobium officinale extract: 5-6 parts;

[0015] Scutellaria baicalensis root extract: 0.5-1 part;

[0016] Acer spicatum extract: 1-2 parts.

[0017] Further preferably, the composition comprises the following mass parts of raw materials:

[0018] Dendrobium officinale extract: 5 parts;

[0019] Scutellaria baicalensis root extract: 0.5 parts;

[0020] Acer spicatum extract: 1 part.

[0021] In a second aspect, the present application provides the use of the composition of the first aspect in the preparation of an after-sun repair skin care product having the effects of soothing red repair and blue light resistance.

[0022] Preferably, the dosage form of the skin care product is any one of cream, emulsion, serum, and mask.

[0023] In a third aspect, the present application provides a serum having the effects of soothing red repair, blue light resistance, and after-sun repair, which comprises the following mass percentage components:

[0024] The composition of the first aspect: 0.1-5wt%;

[0025] Humectant: 10-15wt%;

[0026] Thickening agent: 0.5-1.5wt%;

[0027] Preservative: 0.3-0.5wt%;

[0028] The balance is solvent.

[0029] Preferably, the humectant is glycerin, the thickening agent is carbomer and / or acrylates / C10-30 alkyl acrylate crosspolymer, the preservative is p-hydroxyacetophenone, and the solvent is deionized water.

[0030] In a fourth aspect, the present application provides a preparation method of the serum of the third aspect, comprising the following steps:

[0031] S1: adding a thickening agent and a humectant into a solvent and stirring uniformly to obtain a mixed solution;

[0032] S2: adding a soothing redness-reducing composition, a blue light-resistant composition, a post-sun repair composition, and a preservative into the mixed solution and mixing uniformly to obtain the serum.

[0033] Compared with the prior art, the present application has the following beneficial effects:

[0034] In the composition provided by the present application, the blue light-resistant and repair effects of the dendrobium officinale extract are combined with the soothing redness-reducing effect of the scutellaria baicalensis georgi extract, and the moisturizing effect of the lutea acer extract, so that the adverse reactions such as skin sensitivity and redness can be reduced, the recovery of damaged skin can be accelerated, the skin regeneration can be promoted, and the skin has more resistance when facing various stimulation and sensitivity problems. DETAILED DESCRIPTION

[0035] In order to better understand the present application, the present application will be further described below in combination with specific examples, wherein the terms used in the examples are used for describing specific specific embodiments, and do not constitute a limitation on the protection scope of the present application.

[0036] The experimental methods in the following examples not specified in the specific conditions are usually carried out according to the conventional conditions, or according to the conditions recommended by the manufacturer. Unless otherwise specified, the percentages and parts are calculated by weight.

[0037] Some raw materials and sources are as follows:

[0038] Dendrobium officinale extract: Shaanxi Xiaozhou Biotechnology Co., Ltd., item number AS-01.

[0039] Scutellaria baicalensis georgi extract: Shaanxi Saien Biotechnology Co., Ltd., item number: 10820.

[0040] Lutea acer extract: purchased from Lucas Meyer Company, item number: Expert.

[0041] Other raw materials and reagents are commercially available.

[0042] A post-sun repair composition, the mass ratio of raw materials is specifically as follows:

[0043] Composition 1: Dendrobium officinale extract: 5 parts, Scutellaria baicalensis extract: 0.5 parts, Acer truncatum extract: 1 part.

[0044] Composition 2: Dendrobium officinale extract: 1 part, Scutellaria baicalensis extract: 1 part, Acer truncatum extract: 2 parts.

[0045] Composition 3: Dendrobium officinale extract: 6 parts, Scutellaria baicalensis extract: 0.1 parts, Acer truncatum extract: 0.1 parts.

[0046] Composition ①: Different from composition 1, it lacks Dendrobium officinale extract, and the missing mass parts are made up of Scutellaria baicalensis extract and Acer truncatum extract in a mass ratio of 0.5:1.

[0047] Composition ②: Different from composition 1, it lacks Scutellaria baicalensis extract, and the missing mass parts are made up of Dendrobium officinale extract and Acer truncatum extract in a mass ratio of 5:1.

[0048] Composition ③: Different from composition 1, it lacks Acer truncatum extract, and the missing mass parts are made up of Dendrobium officinale extract and Scutellaria baicalensis extract in a mass ratio of 5:0.5.

[0049] Composition ④: Dendrobium officinale extract: 1 part, Scutellaria baicalensis extract: 5 parts, Acer truncatum extract: 0.5 parts.

[0050] Composition ⑤: Dendrobium officinale extract: 0.5 parts, Scutellaria baicalensis extract: 1 part, Acer truncatum extract: 5 parts.

[0051] An essence with soothing and red repairing, blue light resisting, and post-sun repair effects, the components and mass percentages of which are shown in the following table 1:

[0052] Table 1 Components and mass percentages of an essence with soothing and red repairing, blue light resisting, and post-sun repair effects

[0053] Serum 1 Serum 2 Serum 3 Serum 4 Serum 5 Composition / wt% 2 2 2 0.1 5 Composition No. 1 2 3 1 1 Moisturizer / wt% 13 13 13 15 10 Thickener / wt% 1 1 1 0.5 1.5 Preservative / wt% 0.4 0.4 0.4 0.5 0.3 Solvent / wt% To 100 To 100 To 100 To 100 To 100

[0054] Note: The solvent is deionized water, the humectant is glycerin, the preservative is p-hydroxyacetophenone, and the thickening agent is acrylic acid (ester) / C10-30 alkyl alcohol acrylate cross-linked polymer.

[0055] A specific preparation method of an essence with soothing and red repairing, blue light resisting, and post-sun repair effects is as follows:

[0056] S1: The thickening agent and the humectant are added to the solvent and stirred uniformly to obtain a mixture;

[0057] S2: soothing redness, resist blue light, after-sun repair composition, preservative, add into the mixed solution, mix evenly to obtain the serum.

[0058] Safety test

[0059] Safety evaluation was performed on the serums 1-5 according to the 2015 Cosmetic Safety Technical Specification as a reference standard. 50 people aged 16-65 years were randomly divided into groups, 10 people in each group, and skin patch test was performed respectively.

[0060] Test method: the test substance was placed in the patch tester, the amount was 0.020-0.025g, the patch tester with the test substance was covered on the back or forearm of the test subject with a non-irritating cloth-based adhesive tape, and the hand was pressed lightly to make it evenly attached to the skin surface, lasting for 24 hours. 30 minutes after removing the test patch, the skin reaction was observed after the indentation disappeared. If the result is negative, observe again at 24 hours and 48 hours after the patch test.

[0061] Evaluation criteria:

[0062] 0: negative reaction;

[0063] 1: suspicious reaction, only weak erythema;

[0064] 2: weak positive reaction, erythema, infiltration, edema, and papules may be present;

[0065] 3: strong positive reaction, erythema, infiltration, edema, and papules may be present;

[0066] 4: very strong positive reaction, obvious erythema, severe infiltration, edema, and confluent blisters, and the reaction exceeds the test area.

[0067] Test results: the skin reactions of all test subjects were negative.

[0068] The above test results show that the serum provided by the present application with soothing redness, blue light resistance, and after-sun repair effect is mild and non-irritating to the skin, and is safe to use.

[0069] Efficiency test

[0070] 1. Anti-blue light efficacy evaluation test

[0071] Test samples: compositions 1-3, 1-5, blank 1, blank 2.

[0072] Test sample configuration: use deionized water to configure compositions 1-3, 1-5 into 2wt% mixed solution, blank 1 and blank 2 samples only contain deionized water, and are prepared as needed.

[0073] Test cells: human keratinocytes, concentration 1x10 30.5 x 106cells / mL.

[0074] Test method: 2mL test cells were inoculated into 10 cell culture bottles, and then equal volumes (2mL) of test samples were added in turn, and then placed in a culture box with a blue light source for 24h, wherein blank 2 was shielded from blue light using lightproof tin paper, and after 24h, the cell viability was detected using the MTT detection method.

[0075] Cell viability = OD 测试样品 / OD 空白2 x 100%

[0076] Wherein OD 测试样品 is the OD 650nm value of the test sample; OD 空白2 is the OD 650nm value of blank 2.

[0077] Table 2 cell viability determination

[0078]

[0079]

[0080] Under the action of blue light, human keratinocytes will be damaged to a certain extent, resulting in a decrease in cell viability, so the anti-blue light effect of the composition can be known by determining the cell viability, and the higher the cell viability, the better the anti-blue light effect.

[0081] Comparing the results of the composition and blank 1, it can be known that the composition can effectively resist blue light.

[0082] Comparing the results of compositions 1-3, it can be known that composition 1 has the best anti-blue light effect.

[0083] Comparing the results of composition 1 and compositions ①-③, it can be known that the Dendrobium officinale Kimura et Migo extract, the Scutellaria baicalensis Georgi root extract and the Acer Rubrum extract in the present application have a synergistic effect.

[0084] Comparing the results of composition 1 and compositions ④-⑤, it can be known that when the mass fraction ratio of the Dendrobium officinale Kimura et Migo extract, the Scutellaria baicalensis Georgi root extract and the Acer Rubrum extract in the present application is within the range defined in the present application, the anti-blue light effect of the composition is the best.

[0085] Human body 30s instant soothing effect test

[0086] Test sample: compositions 1-3, ①-⑤, blank.

[0087] Test sample configuration: the test sample was configured into a 2wt% mixture using deionized water, and the blank sample only contained deionized water, and was prepared on demand.

[0088] Volunteer selection criteria: a) 18-60 years old healthy volunteers; b) subjects with no skin lesions / dermatitis in the test site; c) facial skin sensitive and dry; d) positive in lactic acid stinging test.

[0089] The number of volunteers is guaranteed to be more than 30, and the subjects are mainly indoor activities, avoiding long-term exposure to light and high temperature and high cold environment.

[0090] 270 volunteers aged 22-55 with sensitive facial skin (lactic acid stinging test score ≥3 on both sides of the nose) and dry skin were selected. Set up sample group and blank group, and randomly distribute the test area on the left and right faces of the volunteers. After 30 seconds of using the essence of the application, collect the red map by the skin facial image analyzer VISIA7, and analyze the skin redness a* value by Image-Pro Plus (IPP) analysis software to evaluate its moisturizing and soothing effect. The laboratory temperature is 21±1℃, and the relative humidity is 50%±10%.

[0091] The experiment uses self-control method and blank control method, the test period is 30 seconds, and the skin image collection times are 2, which are 0s and 30s respectively. The sample is coated according to the dosage of 0.25g / half face. Qualified subjects are selected according to the requirements. When visiting, wash the face with the specified cleansing product, sit quietly in the test environment for about 20-30 minutes, and start testing after the quiet sitting is over.

[0092] With the help of facial image analyzer VISIA7 (Canfield, USA), the changes of facial skin state are observed.

[0093] With the help of Image-Pro Plus software, the redness a* value is analyzed.

[0094] Skin redness a* value: a* value represents skin redness, and the increase of a* value indicates the increase of skin vascular reactivity.

[0095] The data is analyzed by SPSS19.0 data analysis software.

[0096] Skin redness a* difference = T0-T 30

[0097] T0 is the skin redness a* value when not coated.

[0098] T 30 T is the skin redness a* value after coating the test sample for 30 seconds.

[0099] The greater the skin redness a* difference, the better the soothing effect.

[0100] Table 3 Skin redness a* experimental results

[0101] ​ Test Group Difference Composition 1 8.44 # ]]> Composition 2 8.21 # ]]> Composition 3 8.34 # ]]> Composition 1 4.62 #* ]] Composition 2 4.73 #* ]]> Composition 3 5.04 #* ]]> Composition 4 6.95 #* ]]> Composition 5 6.42 #* ]]> Blank 0.14 #* ]]

[0102] Note: "*" indicates comparison with the blank group, p < 0.05; "*" indicates comparison with composition 1, p < 0.05.

[0103] Analysis of the results in Table 3:

[0104] The results showed that the skin redness a* of compositions 1-3 all decreased, with composition 1 showing the greatest decrease (difference), indicating that the serum prepared using the compositions of the present invention has a soothing effect.

[0105] Comparing the results of composition 1 and compositions ①-③, it can be seen that the extracts of Dendrobium officinale, Scutellaria baicalensis root, and Acer rubrum extract in this invention have a synergistic effect.

[0106] Comparing the results of composition 1 with those of compositions ④-⑤, it can be seen that when the mass ratio of Dendrobium officinale extract, Scutellaria baicalensis root extract, and Acer rubrum extract is within the range defined by this invention, the composition has the best soothing effect.

[0107] The embodiments described above are some, but not all, of the embodiments of this application. The detailed description of the embodiments of this application is not intended to limit the scope of the claimed application, but merely to illustrate selected embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

Claims

1. A composition for soothing redness, protecting against blue light, and repairing sunburn, characterized in that, Includes the following quantities of raw materials: Dendrobium officinale extract: 1-6 parts; Scutellaria baicalensis root extract: 0.1-1 part; Red maple extract: 0.1-2 parts; Among them, the Dendrobium officinale extract was purchased from Shaanxi Xiazhou Biotechnology Co., Ltd., product number AS-01; The Scutellaria baicalensis root extract was purchased from Shaanxi Saien Biotechnology Co., Ltd., product number: 10820; Red maple extract was purchased from Lucas Meyer, product code: Borēaline® Expert.

2. The composition according to claim 1, characterized in that, Includes the following quantities of raw materials: Dendrobium officinale extract: 5-6 parts; Scutellaria baicalensis root extract: 0.5-1 part; Red maple extract: 1-2 parts.

3. The composition according to claim 1, characterized in that, Includes the following quantities of raw materials: Dendrobium officinale extract: 5 parts; Scutellaria baicalensis root extract: 0.5 parts; Red maple extract: 1 part.

4. The use of the composition according to any one of claims 1-3 in the preparation of a skin care product having the effects of soothing redness, protecting against blue light, and repairing sunburn.

5. The application according to claim 4, characterized in that, The skincare product can be any one of the following forms: face cream, lotion, serum, or mask.

6. A serum with soothing and redness-reducing, blue light-protecting, and sun-repairing effects, characterized in that: The serum comprises the soothing, redness-reducing, blue light-protecting, and sun-repairing composition according to any one of claims 1-3, wherein the amount of the composition added to the serum is 0.1-5 wt%.

7. The essence according to claim 6, characterized in that, The serum also includes thickeners, moisturizers, preservatives, and solvents.

8. The essence according to claim 7, characterized in that, The thickener is carbomer and / or acrylate / C10-30 alkanol acrylate crosspolymer, the humectant is glycerin, the preservative is p-hydroxyacetophenone, and the solvent is deionized water.

9. A method for preparing the essence as described in claim 7 or 8, characterized in that, Includes the following steps: S1: Add the thickener and humectant to the solvent and stir until homogeneous to obtain a mixture; S2: Add the soothing, redness-reducing, blue light-protecting, and sun-repairing composition, along with preservatives, to the mixture and mix well to obtain the serum.

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