Disinfectant containing plant extract and preparation method thereof

Abstract

The invention discloses a disinfectant containing plant extracts and a preparation method of the disinfectant. The core of the disinfectant is that a honeysuckle extract, a scutellaria baicalensis extract, a coptis chinensis extract, a rheum officinale extract and triclosan are compounded through a nano-loading technology and placed in a gel matrix to form a slow-release system. The preparation method comprises the following steps: performing HPLC quantitative monitoring on the plant active ingredients; the triclosan and the nano-carrier are processed into a nano-carrier with the average particle size smaller than or equal to 100 nm through technologies such as high-pressure homogenization; and mixing the components with the gel base material, and stabilizing the pH value of the system at 5.5-6.5 by using a pH regulator. The disinfectant disclosed by the invention realizes rapid and broad-spectrum killing of gram-positive bacteria, gram-negative bacteria and fungi by virtue of a synergistic effect of multiple components, and has lasting antibacterial ability by virtue of a nano slow-release effect. The pH value of the product is close to the skin, and the product is detected to be in a non-irritating level and has the advantages of good stability, high safety and suitability for mothers and infants.

Description

Technical Field

[0001] This application relates to the field of disinfectant technology, and more specifically, to a disinfectant containing plant extracts and its preparation method, which is particularly suitable for mothers and infants who have extremely high requirements for safety and mildness. Background Technology

[0002] With increasing public awareness of health, especially among infants and young children whose immune systems are not yet fully developed, the development of safe, effective, and non-irritating disinfection products has become a significant market demand. However, existing disinfectants all have limitations to varying degrees when applied in mother-and-baby settings.

[0003] In the international market, mainstream disinfectants are mainly alcohols such as ethanol and isopropanol, or triclosan-based formulations. While alcohol-based disinfectants are fast-acting, long-term or frequent use can dissolve the skin's natural sebum, leading to dry, cracked skin and increasing the risk of contact dermatitis in children. As for chemical-based formulations, such as triclosan, their widespread use has led to increased resistance to common pathogens like Staphylococcus aureus, resulting in decreased bactericidal efficacy. Furthermore, while Australian tea tree oil products derived from natural plants are favored due to their natural origin, their antibacterial effect against Gram-negative bacteria is generally poor, and the high cost of raw materials limits their large-scale application.

[0004] In the domestic market, chlorine-containing disinfectants (such as 84 disinfectant) and phenolic disinfectants (such as Lysol) are more common. While these products have strong bactericidal capabilities, they are highly irritating and can easily damage the acidic protective film on the skin's surface, altering the skin's microecology and potentially causing burns or allergies to the delicate skin of infants and young children. According to a report in the *Chinese Journal of Disinfection*, the incidence of adverse reactions to these disinfectants in infants and young children exceeds 20%, posing a significant safety hazard. Meanwhile, traditional Chinese medicine-based disinfectant products, such as those containing Artemisia argyi extract, are emerging. These are typically prepared using traditional water extraction processes. However, the active ingredients extracted using this process are complex and unstable, easily degrading and oxidizing during production and storage. This results in large fluctuations in the content of effective ingredients and poor antibacterial durability, making it difficult to meet the requirements for stable and long-lasting disinfection.

[0005] Therefore, there is an urgent need in this field for an innovative disinfection product that can simultaneously achieve high efficiency and broad-spectrum antibacterial activity, long-lasting effect, safety and non-irritation, stable properties, and suitability for mothers and infants. Summary of the Invention

[0006] To address the aforementioned issues, this application provides a disinfectant containing plant extracts and a method for preparing the same.

[0007] The technical solution adopted in this application is as follows: In a first aspect, a disinfectant containing plant extracts comprises the following components: honeysuckle extract, scutellaria baicalensis extract, coptis chinensis extract, rhubarb extract, triclosan, a nanocarrier, a gel matrix, and a pH adjuster; wherein the triclosan is encapsulated in the nanocarrier using nano-loading technology, and then dispersed together with the traditional Chinese medicine extracts in the gel matrix to form a sustained-release system, and the viscosity of the disinfectant is 3000-4000 mPa·s at 25°C.

[0008] Furthermore, based on the total weight of the disinfectant, the content of each component is as follows: Honeysuckle extract, calculated as chlorogenic acid, 0.1%-5%; Scutellaria baicalensis extract, calculated as baicalin, 0.1%-5%; Coptis chinensis extract, calculated as berberine, 0.05%-2%; Rhubarb extract, calculated as emodin, 0.05%-2%; Triclosan 0.05%-1%; Nanocarriers 0.5%-10%; Gel matrix 0.5%-5%; Use an appropriate amount of pH adjuster to maintain the pH value of the system at 5.5-6.5; The remainder is solvent.

[0009] Furthermore, the aforementioned nanocarrier is a nonionic surfactant emulsion, wherein the nonionic surfactant is Tween 80 or poloxamer.

[0010] Furthermore, the aforementioned nano-loading technology is one of high-pressure homogenization emulsification, microencapsulation, or nanofiber loading technology.

[0011] Furthermore, the gel matrix is ​​one or more of carbomer, hydroxypropyl methylcellulose, or sodium alginate.

[0012] Furthermore, the pH adjuster mentioned above is one of the following: a glycerol-triethanolamine buffer system, a citrate-sodium citrate buffer system, or a sodium hydroxide solution.

[0013] Secondly, this application provides a method for preparing the above-mentioned disinfectant containing plant extracts, which includes the following steps: (a) Provide extracts of honeysuckle, scutellaria, coptis and rhubarb, and use high performance liquid chromatography to quantitatively monitor chlorogenic acid, baicalin, berberine and emodin in them; (b) Triclosan was processed with nanocarrier materials using nano-loading technology to obtain triclosan nano-supports with an average particle size ≤100nm; (c) The gel matrix is ​​dispersed in a partial solvent and swollen to form a transparent gel base; (d) Under stirring conditions, the Chinese herbal extract obtained in step (a) and the triclosan nanosupport obtained in step (b) are added sequentially to the gel base obtained in step (c) and mixed evenly. (e) Add a pH adjuster to adjust and maintain the pH of the system at 5.5-6.5, and add the remaining solvent to the total volume. After homogenization, the disinfectant solution is obtained.

[0014] Furthermore, in step (b), when high-pressure homogenization emulsification is used, the pressure is 80-150 MPa and the number of cycles is 3-8. Furthermore, in step (b), when microencapsulation technology is used, the wall material is gelatin, gum arabic, or chitosan.

[0015] In summary, this application has the following beneficial effects: Compared with existing technologies, the disinfectant containing plant extracts and its preparation method provided by this invention, through the integration of a unique component compounding concept and advanced formulation technology, produce a significant synergistic effect, specifically reflected in the following aspects: 1. This invention creatively combines four complementary Chinese herbal extracts (honeysuckle, scutellaria, coptis, and rhubarb) with a low dose of the chemical bactericide triclosan. The four active ingredients (chlorogenic acid, baicalin, berberine, and emodin) act on different targets in the bacterial cell wall, cell membrane, and metabolic processes, forming a multi-pathway synergistic attack with the bactericidal mechanism of triclosan. This combination not only significantly broadens the antibacterial spectrum, exhibiting excellent killing effects against Gram-positive bacteria, Gram-negative bacteria, and fungi (e.g., a kill log of ≥5.00 against Escherichia coli within 2 minutes), but more importantly, this multi-target action mode greatly increases the mutation threshold of microorganisms, effectively delaying or even avoiding the problem of drug resistance easily caused by single components (especially triclosan), thus resolving the contradiction between "high efficiency and drug resistance" in existing technologies.

[0016] 2. This invention overcomes the drawbacks of traditional disinfectants, such as rapid release of active ingredients and short-lived effects, by innovatively introducing nano-loading technology (e.g., high-pressure homogenization emulsification, microencapsulation). By encapsulating triclosan in nanocarriers (e.g., Tween 80, poloxamer, or liposomes) and controlling their particle size to ≤100nm, a slow and controllable release of the active ingredient at the site of action is achieved. This "nano-slow-release reservoir" effect enables the product to not only take effect quickly but also maintain an effective antibacterial concentration for a long time. Testing showed that its 8-hour inhibition zone diameter remained ≥8mm, significantly superior to traditional Chinese medicine water extracts whose active ingredients are easily degraded, thus solving the technical bottleneck of "poor antibacterial durability" in existing plant disinfectants.

[0017] 3. This invention adheres to the principle of "safety and gentleness" from the very beginning of its formulation design. Firstly, a buffer system such as glycerol-triethanolamine precisely stabilizes the product's pH at 5.8±0.2, highly consistent with the natural acidic pH range of healthy skin, avoiding the risk of chlorine- or phenolic disinfectants damaging the skin's acidic protective film. Secondly, the nanoscale dispersion system significantly reduces the direct contact area between irritating substances and the skin. Finally, authoritative testing has shown that the product's safety fully meets the daily use needs of infants and people with sensitive skin, successfully overcoming the industry challenge of "high incidence of adverse reactions" associated with traditional chemical disinfectants. Attached Figure Description

[0018] Figure 1 The process flow diagram of the disinfectant provided in this application. Detailed Implementation

[0019] The embodiments of the present invention will be described in detail below with reference to the examples. However, those skilled in the art will understand that the following examples are only for illustrating the present invention and should not be regarded as limiting the scope of the present invention. Specific conditions not specified in the examples shall be carried out according to conventional conditions or conditions recommended by the manufacturer. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0020] The following provides a detailed description of specific embodiments of the present invention. It should be understood that the specific embodiments described herein are for illustrative and explanatory purposes only and are not intended to limit the scope of the invention.

[0021] Example of raw material preparation Preparation Example 1: Preparation of Honeysuckle Extract 1. Raw materials: Take 1 kg of dried honeysuckle and grind it into coarse powder.

[0022] 2. Extraction: Ultrasonic-assisted ethanol extraction was used. The crude honeysuckle powder was placed in an extraction tank, and 10 times (10L) of 70% ethanol solution was added. Ultrasonic extraction was performed twice at 50℃ (300W power, 40kHz frequency), 30 minutes each time.

[0023] 3. Filtration and Concentration: Combine the two extracts, filter through a 200-mesh filter cloth, and collect the filtrate. Concentrate the filtrate under reduced pressure at 60℃ and -0.08MPa until no alcohol odor remains, to obtain a thick extract.

[0024] 4. Purification: The thick extract was purified by passing it through a macroporous adsorption resin column (model AB-8). First, it was eluted with 5 column volumes of deionized water to remove impurities such as polysaccharides, and then eluted with 6 column volumes of 30% ethanol solution. This ethanol eluent was collected.

[0025] 5. Drying: After the ethanol eluent containing the target component is concentrated again under reduced pressure, it is spray dried (inlet air temperature 180℃, outlet air temperature 90℃) to obtain a light yellow to brownish-yellow honeysuckle extract powder.

[0026] 6. Quality testing: According to the methods in the Chinese Pharmacopoeia, the chlorogenic acid content in this batch of honeysuckle extract was determined by high performance liquid chromatography to be 5.8%.

[0027] Preparation Example 2: Preparation of Scutellaria baicalensis extract 1. Raw materials: Take 1 kg of dried Scutellaria baicalensis and grind it into powder.

[0028] 2. Extraction: The water decoction extraction method was used. The crude powder of Scutellaria baicalensis was added to 12 times (12L) of purified water and heated under reflux for extraction 3 times, each time for 1.5 hours.

[0029] 3. Acid precipitation: Combine the three decoctions and filter while hot through a 200-mesh filter cloth. At 60℃, slowly add hydrochloric acid solution while stirring to adjust the pH of the filtrate to 1.5-2.0. Let stand for 12 hours to allow baicalin to fully precipitate.

[0030] 4. Washing and drying: Discard the supernatant and collect the precipitate. Wash the precipitate successively with a small amount of acidic water (pH=3) and an appropriate amount of ethanol until the washing solution is colorless. Place the precipitate in a vacuum drying oven and dry it at 70°C to constant weight to obtain a yellow powdery Scutellaria baicalensis extract.

[0031] 5. Quality testing: In accordance with the methods in the Chinese Pharmacopoeia, the content of baicalin in the Scutellaria baicalensis extract obtained in this batch was determined by high performance liquid chromatography to be 85%.

[0032] Preparation Example 3: Preparation of Coptis chinensis extract 1. Raw materials: Take 1 kg of dried Coptis chinensis and grind it into coarse powder.

[0033] 2. Extraction: Acid percolation method was used. The coarse powder of the medicinal material was moistened with a 1% sulfuric acid aqueous solution and evenly packed into the percolation cylinder. The same acid aqueous solution was added as the percolate. After soaking for 12 hours, percolation was carried out at a flow rate of 2-3 times the column volume per hour. The percolate was collected until it became colorless.

[0034] 3. Salting out: Add purified sodium chloride to the collected leachate and stir until the solution concentration reaches 7% (w / v). Let it stand overnight to allow berberine hydrochloride to crystallize out. Filter and collect the yellow crystals. Wash the crystals with a small amount of ice-cold acetone to remove impurities.

[0035] 4. Drying: The washed crystals were vacuum dried at 60°C to obtain a yellow needle-like Coptis chinensis extract (mainly berberine hydrochloride).

[0036] 5. Quality testing: In accordance with the methods in the Chinese Pharmacopoeia, the content of berberine in the Coptis chinensis extract obtained in this batch was determined by high performance liquid chromatography to be 90% (calculated as berberine).

[0037] Preparation Example 4: Preparation of Rhubarb Extract 1. Raw materials: Take 1 kg of dried rhubarb and grind it into powder.

[0038] 2. Hydrolysis and Extraction: A continuous extraction method combining acid hydrolysis and organic solvent was employed. Rhubarb powder was mixed with a 2% sulfuric acid aqueous solution and refluxed for 2 hours. After cooling, the mixture was filtered, and the residue was collected and washed with water until neutral. The residue was then placed in a Soxhlet extractor and continuously refluxed with 8 times the volume of chloroform until the extract was colorless.

[0039] 3. Concentration and Extraction: The chloroform was recovered, yielding a brownish-black viscous substance. This viscous substance was extracted with a suitable amount of 1% sodium hydroxide solution, and the alkaline aqueous layer was collected. Hydrochloric acid was slowly added dropwise to the alkaline aqueous layer to adjust the pH to 2-3, at which point free anthraquinone components such as emodin precipitated again.

[0040] 4. Filtration and drying: Filter by suction, collect the precipitate, wash with purified water until neutral, and dry under vacuum at 60°C to obtain an orange-yellow to orange-red rhubarb extract powder.

[0041] 5. Quality testing: Following the methods in the Chinese Pharmacopoeia, the content of emodin in the rhubarb extract obtained in this batch was determined by high performance liquid chromatography to be 3.5%.

[0042] Example 1 This embodiment provides a disinfectant made from plant extracts, which comprises the following components by weight percentage: Active extracts: Honeysuckle extract (calculated as chlorogenic acid) 2.5%; Scutellaria baicalensis extract (calculated as baicalin) 2.5%; Coptis chinensis extract (calculated as berberine) 1.0%; Rheum palmatum extract (calculated as emodin) 1.0%; Triclosan 0.078%; Additives: The nanocarrier is Tween 80, with a content of 5.5%; the gel matrix is ​​sodium alginate, with a content of 3.0%; the pH adjuster is a glycerol-triethanolamine buffer system, in appropriate amount, to maintain the pH value of the system at 5.5-6.5; The remainder is water.

[0043] The preparation method of this disinfectant includes (process flow as follows) Figure 1 As shown): (a) Extracts of honeysuckle, scutellaria, coptis and rhubarb were prepared by preparation examples 1-4; (b) Triclosan and nanocarrier materials were treated by high-pressure homogenization emulsification at a pressure of 80-150 MPa and a cycle of 3-8 times to obtain triclosan nanocarriers with an average particle size of ≤100 nm. (c) The gel matrix is ​​dispersed in a partial solvent and swollen to form a transparent gel base; (d) Under stirring conditions, the Chinese herbal extract obtained in step (a) and the triclosan nanosupport obtained in step (b) are added sequentially to the gel base obtained in step (c) and mixed evenly. (e) Add a pH adjuster to adjust and maintain the pH of the system at 5.5-6.5, and add the remaining solvent to the total volume. After homogenization, the disinfectant solution is obtained.

[0044] Example 2 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: Active extracts: Honeysuckle extract (calculated as chlorogenic acid) 5.0%; Scutellaria baicalensis extract (calculated as baicalin) 1.0%; Coptis chinensis extract (calculated as berberine) 2.0%; Rheum palmatum extract (calculated as emodin) 0.15%.

[0045] The other components and preparation methods are the same as in Example 1.

[0046] Example 3 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: Active extracts: Honeysuckle extract (calculated as chlorogenic acid) 0.15%; Scutellaria baicalensis extract (calculated as baicalin) 5.0%; Coptis chinensis extract (calculated as berberine) 0.15%; Rheum palmatum extract (calculated as emodin) 2.0%; The other components and preparation methods are the same as in Example 1.

[0047] Example 4 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: The content of triclosan is 0.05%.

[0048] The other components and preparation methods are the same as in Example 1.

[0049] Example 5 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: The content of triclosan is 1.0%.

[0050] The other components and preparation methods are the same as in Example 1.

[0051] Example 6 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: Additives: The nanocarrier is Tween 80, with a content of 10%; the gel matrix is ​​sodium alginate, with a content of 5.0%; the pH adjuster is a citric acid-sodium citrate buffer system, in appropriate amount, to maintain the pH value of the system at 5.5-6.5; The other components and preparation methods are the same as in Example 1.

[0052] Example 7 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: Additives: The nanocarrier is Tween 80, with a content of 2.5%; the gel matrix is ​​sodium alginate, with a content of 1.5%; the pH adjuster is a glycerol-triethanolamine buffer system, in appropriate amount, to maintain the pH value of the system at 5.5-6.5; The other components and preparation methods are the same as in Example 1.

[0053] Example 8 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: Additives: The nanocarrier is poloxamer, with a content of 1.5%; the gel matrix is ​​hydroxypropyl methylcellulose, with a content of 0.5%; the pH adjuster is a glycerol-triethanolamine buffer system, in appropriate amounts, to maintain the pH value of the system at 5.5-6.5; The other components and preparation methods are the same as in Example 1.

[0054] Example 9 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: Additives: The nanocarrier is poloxamer, with a content of 4.0%; the gel matrix is ​​carbomer, with a content of 0.5%; the pH adjuster is a glycerol-triethanolamine buffer system, in appropriate amounts, to maintain the pH value of the system at 5.5-6.5; The other components and preparation methods are the same as in Example 1.

[0055] Example 10 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: In step (2) of preparing the disinfectant, triclosan and nanocarrier materials are processed by microencapsulation technology with chitosan as the wall material to obtain triclosan nanocarriers with an average particle size ≤100nm.

[0056] Example 11 This embodiment provides a disinfectant solution made from plant extracts, which differs from Embodiment 1 in that: In step (2) of preparing the disinfectant, triclosan and nanocarrier materials are processed by microencapsulation technology with gum arabic as the wall material to obtain triclosan nanocarriers with an average particle size ≤100nm.

[0057] Comparative Example Comparative Example 1 This comparative example provides a disinfectant that differs from Example 1 in that it does not contain active extracts of traditional Chinese medicine and has a triclosan content of 0.015%.

[0058] Comparative Example 2 This comparative example provides a disinfectant that differs from Example 1 in that it contains 3.5% honeysuckle extract (calculated as chlorogenic acid) and 3.5% scutellaria extract (calculated as baicalin), but does not contain coptis and rhubarb extracts.

[0059] Comparative Example 3 This comparative example provides a disinfectant that differs from Example 1 in that it contains 3.5% Coptis chinensis extract (calculated as berberine) and 3.5% rhubarb extract (calculated as emodin); and does not contain honeysuckle and Scutellaria baicalensis extracts.

[0060] Comparative Example 4 This comparative example provides a disinfectant solution that differs from Example 1 in that it does not contain nanocarrier materials. In the preparation process, the active extract of traditional Chinese medicine and triclosan are added to the gel base in sequence, mixed well, and a pH adjuster is added to adjust and maintain the pH value of the system at 5.5-6.5. At the same time, the remaining solvent is added to the total volume, and the solution is homogenized to obtain the final product.

[0061] Performance testing I. Experimental Methods 1. Quantitative suspension sterilization experiment According to GB / T 38502-2020 "Laboratory Test Methods for the Bactericidal Efficacy of Disinfectants", Escherichia coli (ATCC25922), Staphylococcus aureus (ATCC 6538), and Candida albicans (ATCC 10231) were used as experimental strains. The disinfectants provided in Examples 1 and 10 of this application and Comparative Examples 1-4 were used as test samples. Commercially available 75% ethanol disinfectant was used as a positive control, and phosphate buffer was used as a negative control. The logarithmic kill value (KL) was calculated.

[0062] 2. Antibacterial durability test (1) Inoculation: Use a cotton swab to evenly spread a Staphylococcus aureus suspension with a concentration of 1×10^6 CFU / mL on the surface of an MHA plate.

[0063] (2) Initial sample addition: Take 3 sterile filter paper discs and place them evenly on the inoculated plate. Add 20 μL of the disinfectant solution of this invention and the control sample to the center of 2 of the paper discs respectively. Use the other disc as a blank control (add PBS).

[0064] (3) Initial culture and measurement: After spreading the plates in a 4°C refrigerator for 2-4 hours, transfer them to a 37°C incubator for 18-24 hours. Measure and record the diameter of the inhibition zone (including the diameter of the paper disc) using calipers.

[0065] (4) Simulating sustained action: On another group of inoculated plates, the disinfectant solution of the present invention and the control sample were also added. The plates were first placed at room temperature (25°C) for 8 hours to simulate the continuous action environment of the product on the skin surface.

[0066] (5) Second culture and measurement: After 8 hours, transfer the plate to a 37℃ constant temperature incubator and continue to culture for 18-24 hours. Measure and record the diameter of the inhibition zone again.

[0067] II. The experimental results are shown in Table 1: Table 1. As can be seen from Table 1: Compared to Comparative Examples 1-3, the disinfectant provided in this application has a 2-minute kill log value (KL) of ≥5.00 against Escherichia coli and Candida albicans, which proves that the product of this invention has rapid, broad-spectrum and efficient bactericidal ability.

[0068] The disinfectant provided in this application still showed an inhibition zone diameter of ≥8mm after 8 hours, and this value was significantly greater than that of the control sample (Comparative Example 4) without nano-release technology. This proves that the "nano-release library" effect of the present invention can effectively prolong the action time of the active ingredients and provide long-lasting antibacterial protection.

[0069] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A disinfectant containing plant extracts, characterized in that, It comprises the following components: honeysuckle extract, scutellaria extract, coptis extract, rhubarb extract, triclosan, nanocarrier, gel matrix, and pH adjuster; the triclosan is encapsulated in the nanocarrier using nano-loading technology, and then dispersed together with the traditional Chinese medicine extract in the gel matrix to form a sustained-release system.

2. The disinfectant containing plant extracts according to claim 1, characterized in that, Based on the total weight of the disinfectant, the content of each component is as follows: Honeysuckle extract, calculated as chlorogenic acid, 0.1%-5%; Scutellaria baicalensis extract, calculated as baicalin, 0.1%-5%; Coptis chinensis extract, calculated as berberine, 0.05%-2%; Rhubarb extract, calculated as emodin, 0.05%-2%; Triclosan 0.05%-1%; Nanocarriers: 0.5%-10%; Gel matrix 0.5%-5%; Use an appropriate amount of pH adjuster to maintain the pH value of the system at 5.5-6.5; The remainder is solvent.

3. The disinfectant containing plant extracts according to claim 2, characterized in that, The nanocarrier is a nonionic surfactant emulsion, and the nonionic surfactant is Tween 80 or poloxamer.

4. The disinfectant containing plant extracts according to claim 2, characterized in that, The nano-loading technology is one of high-pressure homogenization emulsification, microencapsulation, or nanofiber loading technology.

5. The disinfectant containing plant extracts according to claim 2, characterized in that, The gel matrix is ​​one or more of carbomer, hydroxypropyl methylcellulose, or sodium alginate.

6. The disinfectant containing plant extracts according to claim 2, characterized in that, The pH adjuster is one of the following: a glycerol-triethanolamine buffer system, a citrate-sodium citrate buffer system, or a sodium hydroxide solution.

7. A method for preparing a disinfectant containing plant extracts as described in any one of claims 1-6, characterized in that, Includes the following steps: (a) Provide extracts of honeysuckle, scutellaria, coptis and rhubarb, and use high performance liquid chromatography to quantitatively monitor chlorogenic acid, baicalin, berberine and emodin in them; (b) Triclosan was processed with nanocarrier materials using nano-loading technology to obtain triclosan nano-supports with an average particle size ≤100 nm; (c) The gel matrix is ​​dispersed in a portion of the solvent and swells to form a transparent gel base; (d) Under stirring conditions, the Chinese herbal extract obtained in step (a) and the triclosan nanosupport obtained in step (b) are added sequentially to the gel base obtained in step (c) and mixed evenly. (e) Add a pH adjuster to adjust and maintain the pH of the system at 5.5-6.5, and add the remaining solvent to the full volume. After homogenization, the disinfectant solution is obtained.

8. The method for preparing the disinfectant containing plant extracts according to claim 7, characterized in that, In step (b), when high-pressure homogenization emulsification is used, the pressure is 80-150 MPa and the number of cycles is 3-8.

9. The method for preparing a disinfectant containing plant extracts according to claim 7, characterized in that, In step (b), when microencapsulation technology is used, the wall material is gelatin, gum arabic, or chitosan.

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