Preparation method of in-situ sodium alginate hydrogel disposable gloves

Abstract

The invention discloses a preparation method of in-situ sodium alginate hydrogel disposable gloves, which is used for forming the sodium alginate hydrogel disposable gloves on the surface of a human hand in situ, and the preparation method comprises the following steps: dissolving sodium alginate and a thickening agent in water to prepare a first solution; dissolving calcium chloride in water to prepare a second solution; after the first solution is uniformly coated on the surface of a hand, the second solution is sprayed on the surface of the first solution, and after gel is formed, the sodium alginate hydrogel disposable gloves are prepared in situ. According to the preparation method of the in-situ sodium alginate hydrogel disposable gloves, the forming process of the sodium alginate hydrogel is transferred to the surface of a human hand, so that the prepared gloves fit with the hand shape are convenient to use, and the sodium alginate hydrogel is degradable and environmentally friendly.

Description

[0001] This application is a divisional application of the invention patent application with the application date of July 28, 2022, application number 2022108983886, and invention title "In-situ Sodium Alginate Hydrogel Disposable Gloves and Preparation Method Thereof". Technical Field

[0002] The present invention belongs to the technical field of gloves, and specifically relates to a preparation method of in-situ sodium alginate hydrogel disposable gloves to form in-situ sodium alginate hydrogel disposable gloves on the surface of the human hand. Background Art

[0003] Most traditional disposable gloves are plastic disposable gloves, latex disposable gloves, rubber disposable gloves, etc., which have the characteristics of low price and convenient use, and are widely used in the fields of food, medicine, chemical industry, electronics, etc.

[0004] However, these gloves are basically prepared through fixed molds. Although there are different specifications and sizes, there are still problems of being too large or too small during use, and it is difficult to perfectly fit the hands of all users. In addition, most traditional disposable gloves are made of non-degradable materials such as plastics and rubbers, which also bring a burden to the environment in the case of large-scale manufacturing and use. Therefore, it is of great significance to design an environmentally friendly disposable glove that can perfectly fit the hand. Summary of the Invention

[0005] In view of this, in order to overcome the defects of the prior art, the purpose of the present invention is to provide an application of sodium alginate hydrogel in in-situ preparation of disposable gloves and a specific preparation method, which can perfectly fit the shape of the hand, is convenient to use, and the sodium alginate hydrogel is degradable and environmentally friendly.

[0006] In order to achieve the above purpose, the present invention adopts the following technical solutions:

[0007] The present invention provides an application of sodium alginate hydrogel in in-situ preparation of disposable gloves.

[0008] The present invention also provides a disposable glove prepared based on the above application.

[0009] According to some preferred embodiments of the present invention, the disposable glove is prepared by the following method:

[0010] Dissolve sodium alginate and thickener in water to prepare a first solution; dissolve calcium chloride in water to prepare a second solution;

[0011] The first solution is evenly applied to the surface of the hand, and the second solution is sprayed onto the surface of the first solution. The mass ratio of the first solution to the second solution is 1:1 to 1.1, and a disposable glove made of sodium alginate hydrogel is prepared in situ. In some embodiments, the second solution can be sprayed onto the surface of the first solution in the form of a spray. After the two solutions come into contact, a hydrogel is rapidly formed on the contact surface, wrapping the entire hand and closely contacting the hand skin.

[0012] According to some preferred embodiments of the present invention, the disposable glove is prepared by the following method:

[0013] Sodium alginate, a thickening agent, and calcium carbonate powder are dissolved in water to prepare a first solution; glucono delta-lactone is dissolved in water to prepare a second solution;

[0014] The first solution and the second solution are mixed evenly and then applied to the surface of the hand. The mass ratio of the first solution to the second solution is 1:1. After the gel is formed, a disposable glove made of sodium alginate hydrogel is prepared in situ. Glucono delta-lactone will slowly hydrolyze and release H + + in the aqueous solution, dissolving calcium carbonate and releasing Ca 2+ 2+ so as to gelate sodium alginate.

[0015] According to some preferred embodiments of the present invention, the viscosity of the first solution is 10000 to 40000 cp.s at 25°C.

[0016] According to some preferred embodiments of the present invention, the mass ratio of calcium chloride or calcium carbonate to sodium alginate is 0.3:1 to 0.8:1. The gloves obtained with the ratio within this range have the best strength. The essence of forming the gel is that calcium ions react chemically with sodium alginate. If there are too few calcium ions, the gel strength is insufficient, and if there are too many calcium ions, it is restricted by the amount of sodium alginate and the reaction no longer continues.

[0017] According to some preferred embodiments of the present invention, the concentration of sodium alginate in the first solution is 1% to 5%.

[0018] According to some preferred embodiments of the present invention, the concentration of calcium chloride is 1% to 5%. If the concentration is too low, the gel strength is insufficient. When the calcium chloride concentration is further increased, the gel performance does not change significantly, and an excessive addition amount will affect the final performance of the glove; the mass concentration of calcium carbonate is 1% to 5%.

[0019] According to some preferred embodiments of the present invention, the concentration of glucono delta-lactone in the second solution is calculated based on the mass ratio of glucono delta-lactone to calcium carbonate being 1:2 to 1:6.

[0020] According to some preferred embodiments of the present invention, the thickener is one or a combination of more than one of carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, and polyvinylpyrrolidone. The thickener is a commonly used thickener in the cosmetics and daily chemical industries, and its function is to adjust the viscosity of the first solution so that it can evenly adhere to the surface of the hand and will not flow down, making the apparent viscosity of the first solution about 10,000 - 40,000 cp.s; if the viscosity is too low, the solution has good fluidity and cannot adhere to the surface of the hand, and if the viscosity is too high, the time required to prepare the solution is too long, reducing production efficiency and being inconvenient to use.

[0021] According to some preferred embodiments of the present invention, the first solution and / or the second solution contains a disinfectant, and the disinfectant is one or a combination of more than one of medical alcohol, quaternary ammonium salt, benzalkonium chloride, triclosan, and polyhexamethylene biguanide. Whether to add and the added concentration can be determined according to the applicable occasion of the disposable gloves. When used in an environment where antibacterial is required, at least the minimum inhibitory concentration needs to be reached.

[0022] The invention principle of this application is as follows: Sodium alginate is a heteropolysaccharide composed of β-1,4-D-mannuronic acid (M) and α-1,4-D-guluronic acid (G), and its molecule contains rich -COO - groups. When a divalent cation is added to an aqueous solution of sodium alginate, the Na + in the G unit will exchange with these divalent cations to form a three-dimensional network structure, causing the sodium alginate solution to transform into a gel. Ca 2+ has both high chelating ability and low biological toxicity and is a divalent cation suitable for preparing sodium alginate hydrogel. It will be formed on the surface of the hand during the transformation of the sodium alginate solution into a gel, so that a disposable glove that fits the hand can be in-situ prepared.

[0023] Due to the implementation of the above technical solutions, the present invention has the following advantages compared with the prior art: The preparation method of the in-situ sodium alginate hydrogel disposable glove in the present invention forms the formation process of the sodium alginate hydrogel on the surface of the human hand, so that the prepared sodium alginate hydrogel forms a glove that fits the hand shape, is convenient to use, and the sodium alginate hydrogel is degradable and environmentally friendly. Detailed Embodiments

[0024] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0025] Sodium alginate is a natural polysaccharide extracted from brown algae, with good biocompatibility and biodegradability. The aqueous solution of sodium alginate easily combines with divalent cations to form a gel. Based on this, the present invention provides an in-situ sodium alginate hydrogel disposable glove and its preparation method, which has the characteristics of environmental friendliness and convenient use, and can perfectly fit the user's hand.

[0026] According to different usage methods (spraying or mixing and smearing), the preparation method of the in-situ disposable glove of the present invention has the following two forms (the concentrations mentioned below are defaulted to mass concentrations):

[0027] The first preparation method includes the following steps:

[0028] 1. Dissolve sodium alginate and thickener in water to prepare a first solution, and the viscosity of the first solution is 10000 - 40000 cp.s (25 °C). Among them, the concentration of sodium alginate is 1% - 5%. If the concentration is too low, the gel layer will be too thin; if it is too high, the viscosity of the solution will be too high, which is inconvenient to use.

[0029] 2. Dissolve calcium chloride and disinfectant in water to prepare a second solution. Among them, the concentration of calcium chloride is 1% - 5%. If its concentration is too low, the gel strength is insufficient. When further increasing the concentration of calcium chloride, the gel performance has no significant change, and an excessive addition amount will affect the final performance of the glove; different disinfectants require different concentrations, and at least the minimum inhibitory concentration should be reached.

[0030] 3. When in use, evenly apply the first solution on the surface of the hand, and then spray the second solution on the surface of the hand in the form of a spray, that is, an in-situ sodium alginate hydrogel disposable glove is prepared on the surface of the hand. After the two solutions come into contact, a hydrogel is quickly formed on the contact surface, wrapping the entire hand and closely contacting the hand skin.

[0031] Before use, it is best to clean and dry the hand to avoid serious dirt or excessive moisture from affecting the formation and use of the glove.

[0032] The second preparation method includes the following steps:

[0033] 1. Dissolve and disperse sodium alginate, thickener, calcium carbonate powder, and disinfectant in water to prepare a first solution, and the viscosity of the first solution is 10000 - 40000 cp.s (25 °C). Among them, the mass concentration of sodium alginate is 1% - 5%. If its concentration is too low, the gel layer will be too thin; if it is too high, the viscosity of the solution will be too high, which is inconvenient to use; the mass concentration of calcium carbonate is 1% - 5%, and different disinfectants require different concentrations, and at least the minimum inhibitory concentration should be reached.

[0034] 2. Dissolve glucono delta-lactone in water to prepare a second solution. The concentration of glucono delta-lactone in the second solution is calculated based on the mass ratio of glucono delta-lactone to calcium carbonate being 1:2 to 1:6. Glucono delta-lactone will slowly hydrolyze in aqueous solution to release H + , dissolve calcium carbonate and release Ca 2+ thus causing the sodium alginate to gelate.

[0035] 3. When in use, mix the first solution and the second solution and apply them to the surface of the hand. After the gel is formed, a sodium alginate hydrogel disposable glove is prepared in situ on the surface of the hand.

[0036] Among them, the thickener is a thickener commonly used in the cosmetics and daily chemical industries, such as carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, polyvinylpyrrolidone, etc. Its function is to adjust the viscosity of the first solution so that it can evenly adhere to the surface of the hand and will not flow down. The required concentrations of different types of thickeners are generally different, and they are adjusted to control the apparent viscosity of the first solution to be about 10,000 - 40,000 cp.s at 25°C. The disinfectant is medical alcohol, quaternary ammonium salt, benzalkonium chloride, triclosan, polyhexamethylene biguanide, etc. The required concentrations of different disinfectants are different, and at least the minimum inhibitory concentration should be reached.

[0037] The hydrogel prepared by the above method has a certain strength and contains a disinfectant component. While serving as a disposable glove, it also plays a role in cleaning and disinfecting the hand.

[0038] Example 1

[0039] The steps for in-situ preparation of a sodium alginate hydrogel disposable glove in this example are as follows:

[0040] 1. Dissolve 3 g of sodium alginate and 0.8 g of thickener in 100 mL of water to prepare a first solution. The viscosity of the first solution is 28,000 cp.s (25°C). The concentration of sodium alginate is 2.9%.

[0041] 2. Dissolve 1.2 g of calcium chloride and 0.2 g of disinfectant in 100 mL of water to prepare a second solution. The concentration of calcium chloride is 1.2%, and the concentration of the disinfectant is 0.2%.

[0042] 3. When in use, evenly apply the first solution on the surface of the hand, and then spray the second solution on the surface of the hand in the form of a spray. The dosage of the second solution is 1.1 times that of the first solution, and a sodium alginate hydrogel disposable glove is prepared in situ on the surface of the hand.

[0043] Example 2

[0044] The steps for in-situ preparation of a sodium alginate hydrogel disposable glove in this example are as follows:

[0045] 1. Dissolve 2 g of sodium alginate and 0.5 g of thickener in 100 mL of water to prepare a first solution, and the viscosity of the first solution is 20,000 cp.s (25 °C). The concentration of sodium alginate is 2%.

[0046] 2. Dissolve 1.4 g of calcium chloride and 0.2 g of disinfectant in 100 mL of water to prepare a second solution. The concentration of calcium chloride is 1.4%, and the concentration of disinfectant is 0.2%.

[0047] 3. When in use, evenly apply the first solution on the surface of the hand, and then spray the second solution on the surface of the hand in the form of a spray. The dosage of the second solution is 1.05 times that of the first solution, that is, a sodium alginate hydrogel disposable glove is prepared in situ on the surface of the hand.

[0048] Example 3

[0049] The steps for in-situ preparation of a sodium alginate hydrogel disposable glove in this example are as follows:

[0050] 1. Dissolve and disperse 3.5 g of sodium alginate, 0.5 g of thickener, 1.2 g of calcium carbonate powder, and 0.2 g of disinfectant in 100 mL of water to prepare a first solution, and the viscosity of the first solution is 25,000 cp.s (25 °C). The mass concentration of sodium alginate is 3.3%; the mass concentration of calcium carbonate is 1.1%.

[0051] 2. Dissolve 0.5 g of glucono-delta-lactone in 100 mL of water to prepare a second solution.

[0052] 3. When in use, mix the first solution and the second solution and apply them on the surface of the hand. The mass ratio of the first solution to the second solution is 1:1. After the gel is formed, a sodium alginate hydrogel disposable glove is prepared in situ on the surface of the hand.

[0053] Example 4

[0054] The steps for in-situ preparation of a sodium alginate hydrogel disposable glove in this example are as follows:

[0055] 1. Dissolve and disperse 2.5 g of sodium alginate, 0.8 g of thickener, 1 g of calcium carbonate powder, and 0.2 g of disinfectant in 100 mL of water to prepare a first solution, and the viscosity of the first solution is 26,000 cp.s (25 °C). The mass concentration of sodium alginate is 2.5%; the mass concentration of calcium carbonate is 1%.

[0056] 2. Dissolve 0.3 g of glucono-delta-lactone in 100 mL of water to prepare a second solution.

[0057] 3. When in use, mix the first solution and the second solution and apply them to the surface of the hand. The mass ratio of the first solution to the second solution is 1:1. After the gel is formed, a sodium alginate hydrogel disposable glove is prepared in situ on the surface of the hand.

[0058] Comparative Example 1

[0059] The difference between this comparative example and Example 1 is that the concentration of calcium chloride in the second solution of this comparative example is 0.5%, resulting in insufficient gel strength and inability to form a disposable glove.

[0060] Comparative Example 2

[0061] The difference between this comparative example and Example 3 is that the concentration of glucono - δ - lactone in the second solution of this comparative example is too low, and the mass ratio of glucono - δ - lactone to calcium carbonate is 1:10, resulting in insufficient gel strength and inability to form a disposable glove.

[0062] Comparative Example 3

[0063] The difference between this comparative example and Example 3 is that the ratio of the first solution to the second solution is 3:1, that is, the proportion of the second solution is too low. The other formulation components and preparation steps are basically the same as those in Example 3. The gel strength obtained in this comparative example is insufficient and unable to form a disposable glove.

[0064] Testing and Results

[0065] Apply the preparation method in the examples to a hand model. After molding, demold to obtain sample gloves, and conduct impermeability and tensile property tests according to the methods specified in GB24786 - 2009. The results are shown in Table 1.

[0066] Table 1 Test Results

[0067] Sample Water impermeability Tensile strength (MPa) Example 1 Qualified 18 Example 2 Qualified 17 Example 3 Qualified 22 Example 4 Qualified 20 Commercially available polyethylene gloves Qualified 17

[0068] Note: The commercially available gloves in the table are disposable polyethylene gloves produced by Haimen Yangzi Medical Devices Co., Ltd.

[0069] It can be seen from the test results in Table 1 that the in - situ sodium alginate hydrogel disposable glove prepared by the present invention can achieve impermeability and tensile strength equal to or better than those of existing commercially available disposable gloves, and can meet the needs of daily use.

[0070] The object of the present invention is to provide an in-situ sodium alginate hydrogel disposable glove, which is environmentally friendly and convenient to use, and can perfectly fit the user's hand. The present invention adopts two methods: dissolving sodium alginate and thickener in water to prepare a first solution; dissolving calcium chloride and disinfectant in water to prepare a second solution. When in use, the first solution is evenly applied on the surface of the hand, so that a layer of sodium alginate solution covers the surface of the hand, and then the second solution is sprayed on the surface of the hand in the form of a spray. After the two solutions come into contact, a hydrogel is rapidly formed on the contact surface, wrapping the entire hand and closely contacting the hand skin; or, sodium alginate, thickener, calcium carbonate powder, and disinfectant are dissolved in water and dispersed evenly to obtain a first solution, and glucono delta-lactone is dissolved in a small amount of water to obtain a second solution. Before use, the first solution and the second solution are mixed evenly and then applied on the surface of the hand. After the solution gels, the gel layer will wrap the entire hand and closely contact the hand skin; wherein glucono delta-lactone will slowly hydrolyze and release H + , causing calcium carbonate to dissolve and release Ca 2+ , thereby gelling sodium alginate. The disposable glove of the present invention can be generated in-situ on the surface of the hand, perfectly fit the shape of the hand, and is convenient to use, avoiding the problems of difficult wearing and inappropriate size of ordinary disposable gloves; it is a degradable sodium alginate hydrogel, which is green and environmentally friendly; functional materials can be added in appropriate amounts according to actual needs. For example, when a disinfectant is added, it also has the function of hand disinfection.

[0071] Although the name of this application is disposable glove, under the premise of meeting various usage requirements, it can also achieve the purpose of multiple uses.

[0072] The above embodiments are only used to illustrate the technical concept and characteristics of the present invention, and their purpose is to enable those who are familiar with this technology to understand the content of the present invention and implement it accordingly. It cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit and essence of the present invention should be covered within the protection scope of the present invention.

Claims

1. A method for preparing an in-situ sodium alginate hydrogel disposable glove, which is used to form an in-situ sodium alginate hydrogel disposable glove on the surface of a human hand, and is characterized in that, The preparation method comprises the following steps: Dissolve sodium alginate and a thickening agent in water to prepare a first solution; Dissolve calcium chloride in water to prepare a second solution; After evenly coating the first solution on the surface of the hand, spray the second solution on the surface of the first solution. After the gel is formed, a disposable glove made of sodium alginate hydrogel is prepared in situ.

2. The preparation method according to claim 1, characterized in that, The second solution is sprayed on the surface of the first solution in the form of a spray. After the second solution and the first solution come into contact, a hydrogel is formed on the contact surface, wrapping the entire hand and closely contacting the hand skin, and a disposable glove made of sodium alginate hydrogel is formed in situ.

3. The preparation method according to claim 1, characterized in that, The viscosity of the first solution at 25 °C is 10,000 to 40,000 cp.s.

4. The preparation method according to claim 1, characterized in that, The mass ratio of calcium chloride to sodium alginate is 0.3:1 to 0.8:

1.

5. The preparation method according to claim 1, characterized in that, The concentration of sodium alginate in the first solution is 1% to 5%.

6. The preparation method according to claim 1, characterized in that, The concentration of calcium chloride in the second solution is 1% to 5%.

7. The preparation method according to claim 1, characterized in that, The thickening agent is a combination of one or more selected from carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, and polyvinylpyrrolidone.

8. The preparation method according to claim 1, characterized in that, The first solution and / or the second solution contains a disinfectant.

9. The preparation method according to claim 8, wherein The disinfectant is a combination of one or more selected from medical alcohol, quaternary ammonium salts, benzalkonium chloride, triclosan, and polyhexamethylene biguanide.

10. The preparation method according to any one of claims 1-9, characterized in that, The steps further include cleaning and drying the hand before evenly coating the first solution on the surface of the hand.

11. A disposable glove made of in-situ sodium alginate hydrogel prepared by the preparation method according to any one of claims 1-10.