A Chinese medicine external-use drug delivery device with convenient adjustment of drug delivery rate

Abstract

The present invention discloses a Chinese medicine external-use drug delivery device that is convenient for adjusting the drug delivery rate, comprising a drug delivery head with a cavity inside, an EVA film fixedly connected to the bottom of the drug delivery head, a large number of micropores provided on the EVA film, a magnetic plate connected to the top of the drug delivery head via a lifting and adjusting device, the lifting and adjusting device being used to control the distance between the magnetic plate and the drug delivery head, a liquid guide tube fixedly connected to the side wall of the drug delivery head, a liquid storage ball fixedly connected to one end of the liquid guide tube, and a hanging ring fixedly connected to the top of the liquid storage ball. The present invention realizes continuous and stable release of external-use drugs through the thermomagnetic effect, is simple to operate, solves the limitations of traditional drug delivery methods, and shows great potential in the fields of chronic disease management, local treatment, etc., and by controlling the distance between the magnetic plate and the drug delivery head, the transdermal drug delivery rate can be adjusted to achieve adjustment of the drug delivery rate according to the condition of the disease.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a Chinese medicine external-use drug delivery device which is convenient for adjusting drug delivery rate. Background Art

[0002] Liquid Chinese herbal topical preparations can play a unique role in clinical treatment through continuous transdermal administration. They are particularly suitable for conditions that require local sustained effects or avoid oral administration, such as local treatment of chronic skin diseases (such as psoriasis and eczema).

[0003] Existing methods of administering liquid Chinese herbal topical preparations generally involve nurses manually applying or pouring them onto the lesions. However, for patients with some chronic diseases (such as psoriasis and diabetic foot ulcers) who require long-term medication, traditional methods of administration not only require frequent manual application, which is difficult for those with limited mobility, but also cannot adjust the transdermal delivery rate according to the condition of the patient.

[0004] Therefore, it is necessary to design a Chinese medicine external-use drug delivery device that is easy to adjust the drug delivery rate. Summary of the Invention

[0005] The present invention provides a Chinese medicine external-use drug dispenser that is convenient for adjusting the drug delivery rate, so as to solve the problems raised in the above-mentioned background technology.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A Chinese medicine external-use dosing device that facilitates adjustment of dosing rate, comprising a dosing head with a cavity inside, an EVA film fixedly connected to the bottom of the dosing head, the EVA film being provided with a large number of micropores, a magnetic plate connected to the top of the dosing head via a lifting and adjusting device, the lifting and adjusting device being used to control the distance between the magnetic plate and the dosing head, a liquid guide tube fixedly connected to the side wall of the dosing head, a liquid storage ball fixedly connected to one end of the liquid guide tube, a hanging ring fixedly connected to the top of the liquid storage ball, and a Chinese medicine external-use drug stored in the liquid storage ball, the liquid guide tube, and the dosing head;

[0008] The traditional Chinese medicine external preparation is composed of paramagnetic particles and traditional Chinese medicine liquid. The paramagnetic particles are nanometer γ-Fe2O3 particles with primary amine groups modified on the surface. The paramagnetic particles are used to give the traditional Chinese medicine external preparation magnetism.

[0009] Preferably, the lifting and adjusting device includes a threaded rod and a limit plate, the threaded rod is rotatably connected to the upper side of the dosing head, the limit plate is fixedly connected to the upper side of the dosing head, the magnetic plate is threadedly connected to the threaded rod, the limit plate passes through the side wall of the magnetic plate, and the upper end of the threaded rod is fixedly connected to a baffle.

[0010] Preferably, a scale is provided on the side wall of the limiting plate.

[0011] Preferably, a fixing ring is fixedly connected to the periphery of the bottom of the dosing head, an adhesive layer is provided on the bottom side wall of the fixing ring, and a release paper is provided on the bottom side wall of the adhesive layer.

[0012] Preferably, the EVA film has a thickness of 200 μm, and the micropores on the EVA film have a pore size of 100-500 nm.

[0013] Preferably, the preparation method of the nano γ-Fe2O3 particles with surface modified primary amine groups is:

[0014] S1, solvent dispersion: γ-Fe2O3 nanoparticles were dispersed in anhydrous ethanol and sonicated for 30 min to form a homogeneous suspension;

[0015] S2, surface modification reaction: heat to 60-80°C and stir for 4-8 hours to hydrolyze APTES and react with the hydroxyl groups on the surface of γ-Fe2O3;

[0016] S3, centrifugation: After the reaction is completed, the modified nanoparticles are separated by centrifugation and washed with ethanol several times to remove unreacted APTES;

[0017] S4, drying: drying the modified nanoparticles in a vacuum at 40-60° C. to obtain nano-γ-Fe 2 O 3 particles with primary amine groups modified on the surface.

[0018] Preferably, the liquid storage ball is located above the dosing head.

[0019] Preferably, the method of using the Chinese medicine external-use applicator is:

[0020] The first step is to remove the release paper so that the EVA film on the bottom side of the drug delivery head is attached to the patient's skin lesion. The adhesive layer on the bottom side of the fixing ring can fix the drug delivery head on the skin.

[0021] The second step is to hang the liquid storage ball on the patient's clothes through the hanging ring so that the liquid storage ball is above the medication head;

[0022] In the third step, before the EVA film is attached to the skin, the Chinese herbal external preparation in the dosing head is magnetized by the magnetic field force of the magnetic plate, and the viscosity of the Chinese herbal external preparation in the dosing head increases sharply and the fluidity decreases. Since the magnetic susceptibility of the Chinese herbal external preparation decreases with increasing temperature, when the EVA film is attached to the skin, the heat from the skin enters the Chinese herbal external preparation in the dosing head, and the magnetism of the Chinese herbal external preparation in the dosing head decreases after being heated, and the viscosity of the Chinese herbal external preparation is restored. The Chinese herbal external preparation in the dosing head can penetrate the EVA film and enter the dermis through the lipids between skin cells to complete the dosing.

[0023] Preferably, in the third step, because the temperature of the Chinese herbal external preparation in the dosing head increases, the magnetism of the Chinese herbal external preparation in the dosing head gradually decreases. At this time, the Chinese herbal external preparation in the catheter connected to one side of the dosing head is not affected by body temperature. After the magnetism of the Chinese herbal external preparation in the catheter is greater than that in the dosing head, the Chinese herbal external preparation in the catheter is driven by the magnetic field force of the magnetic plate, and the Chinese herbal external preparation in the storage ball will continue to flow through the catheter into the dosing head, and by controlling the distance between the magnetic plate and the dosing head, the closer the magnetic plate is to the dosing head, the greater the magnetic field force on the Chinese herbal external preparation in the dosing head, and thus the speed at which the Chinese herbal external preparation in the catheter flows into the dosing head increases, and the skin delivery rate of the Chinese herbal external preparation in the dosing head increases, thereby realizing the regulation of the delivery rate.

[0024] Preferably, the EVA film changes from a glassy state to a highly elastic state at body temperature, which can improve the diffusion efficiency of drug molecules in the external Chinese medicine.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] The present invention achieves continuous and stable release of topical drugs through the thermomagnetic effect. It is simple to operate and solves the limitations of traditional drug delivery methods. It shows great potential in the fields of chronic disease management and local treatment. By controlling the distance between the magnetic plate and the drug delivery head, the transdermal drug delivery rate can be adjusted, thereby achieving adjustment of the drug delivery rate according to the condition of the disease.

[0027] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention and to implement it according to the contents of the description, the following preferred embodiments of the present invention are described in detail with reference to the accompanying drawings. The specific implementation methods of the present invention are given in detail by the following embodiments and the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of this application. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0029] Figure 1 This is a schematic diagram of the overall structure of a Chinese medicine external-use drug delivery device that is convenient for adjusting the drug delivery rate, as proposed by the present invention;

[0030] Figure 2 This is a schematic cross-sectional view of the drug delivery head proposed in the present invention;

[0031] Figure 3 This is a schematic diagram of the overall structure of a Chinese medicine external-use drug delivery device proposed by the present invention, which is convenient for adjusting the drug delivery rate.

[0032] In the accompanying drawings, the components represented by the reference numerals are as follows:

[0033] 1. Release paper; 2. Fixing ring; 3. Dosing head; 4. Magnetic plate; 5. Limiting plate; 6. Threaded rod; 7. Baffle; 8. Liquid guide tube; 9. Liquid storage ball; 10. Hanging ring; 11. Traditional Chinese medicine for external use; 12. EVA film; 13. Adhesive layer. DETAILED DESCRIPTION

[0034] The principles and features of the present invention are described below with reference to the accompanying drawings. The examples provided are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. The following paragraphs describe the present invention in more detail by way of example with reference to the accompanying drawings. It should be noted that the drawings are all in a very simplified form and are not to exact scale, and are only used for the purpose of conveniently and clearly illustrating the embodiments of the present invention.

[0035] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used in this specification of the present invention are for the purpose of describing specific embodiments only and are not intended to limit the present invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0036] See also Figures 1 to 3 In an embodiment of the present invention, a Chinese medicine external preparation dosing device that is convenient for adjusting the dosing rate includes a dosing head 3 with a cavity inside. An EVA (ethylene-vinyl acetate copolymer) film 12 is fixedly connected to the bottom of the dosing head 3. The EVA film 12 is provided with a large number of micropores. The EVA film 12 has a thickness of 200 μm and a pore size of 100-500 nm. The EVA film 12 transforms from a glassy state to a highly elastic state at body temperature (approximately 32-37°C), thereby improving the diffusion efficiency of drug molecules in the Chinese medicine external preparation 11.

[0037] The top of the dosing head 3 is connected to the magnetic plate 4 through a lifting and adjusting device. The lifting and adjusting device is used to control the distance between the magnetic plate 4 and the dosing head 3. The lifting and adjusting device includes a threaded rod 6 and a limit plate 5. The threaded rod 6 is rotatably connected to the upper side of the dosing head 3, and the limit plate 5 is fixedly connected to the upper side of the dosing head 3. The magnetic plate 4 is threadedly connected to the threaded rod 6. The limit plate 5 passes through the side wall of the magnetic plate 4. The upper end of the threaded rod 6 is fixedly connected to a baffle 7. A scale ruler is provided on the side wall of the limit plate 5, and the distance between the magnetic plate 4 and the dosing head 3 can be checked by the scale ruler.

[0038] A liquid guide tube 8 is fixedly connected to the side wall of the dosing head 3, one end of the liquid guide tube 8 is fixedly connected to a liquid storage ball 9, the top of the liquid storage ball 9 is fixedly connected to a hanging ring 10, and a Chinese medicine external preparation 11 is stored in the liquid storage ball 9, the liquid guide tube 8 and the dosing head 3. A fixing ring 2 is fixedly connected to the bottom periphery of the dosing head 3, and an adhesive layer 13 is provided on the bottom side wall of the fixing ring 2, and a release paper 1 is provided on the bottom side wall of the adhesive layer 13;

[0039] The Chinese medicine external preparation 11 is composed of paramagnetic particles and Chinese medicine liquid. The paramagnetic particles are used to give the Chinese medicine external preparation 11 magnetism. The paramagnetic particles are nano γ-Fe2O3 particles with primary amine groups modified on the surface. The nano γ-Fe2O3 particles can load a large amount of drugs or biological molecules in the Chinese medicine external preparation 11, and then penetrate through skin appendages (such as hair follicles, sebaceous glands) or stratum corneum gaps. The surface modification of the nano γ-Fe2O3 particles with primary amine groups helps to enhance skin permeability, and the surface modification has biocompatibility, which can achieve non-toxic, non-irritating, and non-allergic drug delivery through the skin.

[0040] The preparation method of nano γ-Fe2O3 particles with surface modified primary amine groups is as follows:

[0041] S1, solvent dispersion: γ-Fe2O3 nanoparticles were dispersed in anhydrous ethanol and sonicated for 30 min to form a homogeneous suspension;

[0042] S2, surface modification reaction: heat to 60-80°C and stir for 4-8 hours to hydrolyze APTES (3-aminopropyltriethoxysilane) and react with the hydroxyl groups on the surface of γ-Fe2O3;

[0043] S3, centrifugation: After the reaction is completed, the modified nanoparticles are separated by centrifugation and washed with ethanol several times to remove unreacted APTES;

[0044] S4, drying: drying the modified nanoparticles in a vacuum at 40-60° C. to obtain nano-γ-Fe 2 O 3 particles with primary amine groups modified on the surface.

[0045] The method of using the Chinese medicine external-use applicator is as follows:

[0046] In the first step, first remove the release paper 1 so that the EVA film 12 on the bottom side of the drug delivery head 3 is attached to the patient's skin lesion. The adhesive layer 13 on the bottom side of the fixing ring 2 can fix the drug delivery head 3 on the skin.

[0047] The second step is to hang the liquid storage ball 9 on the patient's clothes or on a rack through the hanging ring 10, ensuring that the liquid storage ball 9 is located above the medication head 3;

[0048] In the third step, before the EVA film 12 is attached to the skin, the Chinese herbal medicine 11 in the dosing head 3 is subjected to the magnetic field force of the magnetic plate 4 and generates magnetism, and the viscosity of the Chinese herbal medicine 11 in the dosing head 3 increases sharply and the fluidity decreases. Since the magnetic susceptibility of the Chinese herbal medicine 11 decreases with increasing temperature, when the EVA film 12 is attached to the skin, the heat of the skin enters the Chinese herbal medicine 11 in the dosing head 3, and the magnetism of the Chinese herbal medicine 11 in the dosing head 3 decreases after being heated, and the viscosity of the Chinese herbal medicine 11 is restored. The nano-γ-Fe2O3 particles in the Chinese herbal medicine 11 in the dosing head 3 can load a large amount of drugs or biomolecules, and then pass through the EVA film 12 and enter the dermis through the intercellular lipids of the skin to complete the drug administration;

[0049] Among them, because the temperature of the Chinese herbal external preparation 11 in the dosing head 3 increases, the magnetism of the Chinese herbal external preparation 11 in the dosing head 3 gradually decreases. At this time, the Chinese herbal external preparation 11 in the catheter tube 8 connected to one side of the dosing head 3 is not affected by body temperature. After the magnetism of the Chinese herbal external preparation 11 in the catheter tube 8 is greater than that of the Chinese herbal external preparation 11 in the dosing head 3, the Chinese herbal external preparation 11 in the catheter tube 8 is driven by the magnetic field force of the magnetic plate 4. The Chinese herbal external preparation 11 in the liquid storage ball 9 will continue to flow through the catheter tube 8 into the dosing head 3, and by controlling the distance between the magnetic plate 4 and the dosing head 3, the closer the magnetic plate 4 is to the dosing head 3, the greater the magnetic field force on the Chinese herbal external preparation 11 in the dosing head 3, and then the speed at which the Chinese herbal external preparation 11 in the catheter tube 8 flows into the dosing head 3 increases, and the skin delivery rate of the Chinese herbal external preparation 11 in the dosing head 3 increases, thereby realizing the regulation of the delivery rate.

[0050] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Any ordinary technician in this industry can smoothly implement the present invention as shown in the drawings and described above. However, any equivalent changes, modifications and evolutions made by technicians familiar with this profession without departing from the scope of the technical solution of the present invention using the technical content disclosed above are all equivalent embodiments of the present invention. At the same time, any equivalent changes, modifications and evolutions made to the above embodiments based on the essential technology of the present invention are still within the scope of protection of the technical solution of the present invention.

Claims

1. A Chinese medicine external-use drug delivery device that is convenient for adjusting the delivery rate, comprising a delivery head (3) with a cavity inside, characterized in that: The bottom of the dosing head (3) is fixedly connected to an EVA film (12), and a large number of micropores are provided on the EVA film (12). The top of the dosing head (3) is connected to a magnetic plate (4) via a lifting and adjusting device, and the lifting and adjusting device is used to control the distance between the magnetic plate (4) and the dosing head (3). A liquid guide tube (8) is fixedly connected to the side wall of the dosing head (3), and one end of the liquid guide tube (8) is fixedly connected to a liquid storage ball (9). The top of the liquid storage ball (9) is fixedly connected to a hanging ring (10). The liquid storage ball (9), the liquid guide tube (8) and the dosing head (3) store a Chinese medicine for external use (11); The lifting and adjusting device comprises a threaded rod (6) and a limit plate (5), wherein the threaded rod (6) is rotatably connected to the upper side of the dosing head (3), the limit plate (5) is fixedly connected to the upper side of the dosing head (3), the magnetic plate (4) is threadedly connected to the threaded rod (6), the limit plate (5) passes through the side wall of the magnetic plate (4), and the upper end of the threaded rod (6) is fixedly connected to a baffle (7); The Chinese medicine external preparation (11) is composed of paramagnetic particles and Chinese medicine liquid, wherein the paramagnetic particles are nano γ-Fe2O3 particles with primary amine groups modified on the surface, and the paramagnetic particles are used to impart magnetic properties to the Chinese medicine external preparation (11); The EVA film (12) changes from a glassy state to a highly elastic state at body temperature, thereby improving the diffusion efficiency of drug molecules in the traditional Chinese medicine for external use (11).

2. A Chinese medicine external-use drug delivery device that is convenient for adjusting the drug delivery rate according to claim 1, characterized in that: A scale is provided on the side wall of the limiting plate (5).

3. A Chinese medicine external-use drug delivery device that is convenient for adjusting drug delivery rate according to claim 2, characterized in that: A fixing ring (2) is fixedly connected to the periphery of the bottom of the dosing head (3), an adhesive layer (13) is provided on the bottom side wall of the fixing ring (2), and a release paper (1) is provided on the bottom side wall of the adhesive layer (13).

4. A Chinese medicine external-use drug delivery device that is convenient for adjusting drug delivery rate according to claim 3, characterized in that: The EVA film (12) has a thickness of 200 μm, and the micropore diameter on the EVA film (12) is 100-500 nm.

5. A Chinese medicine external-use drug delivery device that is convenient for adjusting drug delivery rate according to claim 4, characterized in that: The preparation method of the nano γ-Fe2O3 particles with surface modified primary amine groups is as follows: S1, solvent dispersion: γ-Fe2O3 nanoparticles were dispersed in anhydrous ethanol and sonicated for 30 min to form a homogeneous suspension; S2, surface modification reaction: heat to 60-80°C and stir for 4-8 hours to hydrolyze APTES and react with the hydroxyl groups on the surface of γ-Fe2O3; S3, centrifugation: After the reaction is completed, the modified nanoparticles are separated by centrifugation and washed with ethanol several times to remove unreacted APTES; S4, drying: drying the modified nanoparticles in a vacuum at 40-60° C. to obtain nano-γ-Fe 2 O 3 particles with primary amine groups modified on the surface.

6. A Chinese medicine external preparation dispenser that is convenient for adjusting the dosing rate according to claim 5, characterized in that: The liquid storage ball (9) is located above the dosing head (3).

7. A Chinese medicine external-use drug delivery device that is convenient for adjusting drug delivery rate according to claim 6, characterized in that: The method of using the Chinese medicine external-use applicator is as follows: In the first step, the release paper (1) is removed so that the EVA film (12) on the bottom side of the drug delivery head (3) is attached to the patient's skin lesion, and the adhesive layer (13) on the bottom side of the fixing ring (2) can fix the drug delivery head (3) on the skin; The second step is to hang the liquid storage ball (9) on the patient's clothes through the hanging ring (10) so that the liquid storage ball (9) is located above the drug delivery head (3); In the third step, before the EVA film (12) is attached to the skin, the Chinese herbal medicine (11) in the dosing head (3) is subjected to the magnetic field force of the magnetic plate (4) and generates magnetism. The viscosity of the Chinese herbal medicine (11) in the dosing head (3) increases sharply and the fluidity decreases. Since the magnetic susceptibility of the Chinese herbal medicine (11) decreases with increasing temperature, when the EVA film (12) is attached to the skin, the heat of the skin enters the Chinese herbal medicine (11) in the dosing head (3). The magnetism of the Chinese herbal medicine (11) in the dosing head (3) decreases after being heated, and the viscosity of the Chinese herbal medicine (11) is restored. The Chinese herbal medicine (11) in the dosing head (3) can penetrate the EVA film (12) and enter the dermis through the intercellular lipids of the skin, completing the dosing.

8. A Chinese medicine external-use drug delivery device that is convenient for adjusting drug delivery rate according to claim 7, characterized in that: In the third step, because the temperature of the Chinese herbal medicine (11) in the dosing head (3) increases, the magnetism of the Chinese herbal medicine (11) in the dosing head (3) gradually decreases. At this time, the Chinese herbal medicine (11) in the catheter (8) connected to one side of the dosing head (3) is not affected by the body temperature. After the magnetism of the Chinese herbal medicine (11) in the catheter (8) is greater than that of the Chinese herbal medicine (11) in the dosing head (3), the Chinese herbal medicine (11) in the catheter (8) is driven by the magnetic force of the magnetic plate (4), and the liquid storage ball (9) is moved. ) will continue to flow into the drug delivery head (3) through the liquid guide tube (8), and by controlling the distance between the magnetic plate (4) and the drug delivery head (3), the closer the magnetic plate (4) is to the drug delivery head (3), the greater the magnetic field force on the Chinese herbal medicine (11) in the drug delivery head (3), and thus the speed at which the Chinese herbal medicine (11) in the liquid guide tube (8) flows into the drug delivery head (3) increases, and the skin delivery rate of the Chinese herbal medicine (11) in the drug delivery head (3) increases, thereby achieving regulation of the drug delivery rate.

Images