Cosmetic

Abstract

A cosmetic comprising: (A) a polyglycerol fatty acid ester-based surfactant; (B) an aliphatic alcohol having 8-40 carbon atoms; (C) one or more compounds selected from the group consisting of compounds represented by general formula (1) and pharmacologically acceptable salts thereof (in general formula (1), R1, R3, R4 and R6 each independently represent an alkyl group having 1-3 carbon atoms, and R2 and R5 each independently represent a hydrogen atom or an alkyl group having 1-3 carbon atoms); (D) a thickener having a structure represented by general formula (2) (in general formula (2), R7 and R8 each independently represent a hydrogen atom or an alkyl group having 1-3 carbon atoms); and (E) water. # imgabs0 #

Description

Technical Field

[0001] The present invention relates to a cosmetic. Specifically, it relates to a stable cosmetic having a whitening effect. Background Art

[0002] In order to use a cosmetic comfortably, the feel when applied to the skin or the like is important. For example, an oil-in-water type emulsified cosmetic exhibits a viscous state with a smooth surface state, and when applied to the skin, it can suppress the evaporation of moisture from the skin and give the skin a moist feeling.

[0003] Patent Document 1 describes an oil-in-water type emulsified composition prepared by mixing glycerin, water, a polar oil, and a polyglycerol fatty acid ester, and states that it has excellent feel in use and compatibility with makeup.

[0004] On the other hand, as a topical skin agent having an excellent whitening effect, pyrimidinylpyrazole compounds are known. For example, Patent Document 2 describes that pyrimidinylpyrazole compounds have an excellent effect of inhibiting melanin production in skin pigment cells and are useful as whitening agents.

[0005] Prior Art Documents

[0006] Patent Documents

[0007] Patent Document 1: Japanese Patent Application Laid-Open No. 2007-153754

[0008] Patent Document 2: Japanese Patent No. 4586108 Summary of the Invention

[0009] Problems to be Solved by the Invention

[0010] The above-mentioned polyglycerol fatty acid ester has high safety and low irritation, and the feel of the cosmetic containing it on the skin becomes good. However, if a pyrimidinylpyrazole compound is mixed in a cosmetic containing a polyglycerol fatty acid ester and a higher alcohol in order to impart a whitening effect, the uniform state of the cosmetic is gradually destroyed and finally separation occurs.

[0011] The present invention has been made in view of the above circumstances. An object of the present invention is to provide a stable cosmetic having a whitening effect.

[0012] Means for Solving the Problems

[0013] The present invention is as follows.

[0014] <<Solution 1>> A cosmetic comprising:

[0015] (A) a polyglycerol fatty acid ester surfactant;

[0016] (B) an aliphatic alcohol having 8 to 40 carbon atoms;

[0017] (C) One or more selected from the compounds represented by the following general formula (1) and their pharmacologically acceptable salts;

[0018] (D) A thickener having the structure represented by the following general formula (2); and

[0019] (E) Water.

[0020]

[0021] (In general formula (1), R1, R3, R4 and R6 are each independently an alkyl group having 1 to 3 carbon atoms, and R2 and R5 are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)

[0022]

[0023] (In general formula (2), R7 and R8 are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)

[0024] "Scheme 2" The cosmetic according to Scheme 1, wherein R7 and R8 in the above general formula (2) are methyl groups.

[0025] "Scheme 3" The cosmetic according to Scheme 2, wherein the above component (D) is selected from

[0026] The copolymer of acryloyldimethyltaurine ammonium and N-vinylpyrrolidone, and

[0027] The copolymer of sodium acryloyldimethyltaurate, dimethylacrylamide and methylenebisacrylamide

[0028] One or more of them.

[0029] "Scheme 4" The cosmetic according to Scheme 1, wherein the HLB value of the above component (A) is 10 or more and 17 or less.

[0030] "Scheme 5" The cosmetic according to Scheme 1, wherein the above component (C) is selected from

[0031] The compound in which R1, R3, R4 and R6 in the above general formula (1) are methyl groups and R2 and R5 are hydrogen atoms,

[0032] The compound in which R1, R2, R3, R4 and R6 in the above general formula (1) are methyl groups and R5 is a hydrogen atom, and

[0033] The compound in which R1, R3, R4 and R6 in the above general formula (1) are methyl groups and R2 and R5 are ethyl groups

[0034] One or more of them.

[0035] Cosmetic according to Plan 6: The above-mentioned component (C) is selected from

[0036] compounds in which R1, R3, R4 and R6 in the above general formula (1) are methyl groups and R2 and R5 are hydrogen atoms,

[0037] compounds in which R1, R2, R3, R4 and R6 in the above general formula (1) are methyl groups and R5 is a hydrogen atom, and

[0038] compounds in which R1, R3, R4 and R6 in the above general formula (1) are methyl groups and R2 and R5 are ethyl groups

[0039] among which are one or more.

[0040] Cosmetic according to Plan 7: The above-mentioned component (C) is selected from

[0041] compounds in which R1, R3, R4 and R6 in the above general formula (1) are methyl groups and R2 and R5 are hydrogen atoms,

[0042] compounds in which R1, R2, R3, R4 and R6 in the above general formula (1) are methyl groups and R5 is a hydrogen atom, and

[0043] compounds in which R1, R3, R4 and R6 in the above general formula (1) are methyl groups and R2 and R5 are ethyl groups

[0044] among which are one or more.

[0045] Cosmetic according to Plan 8: The cosmetic according to any one of Plans 1 to 7 further contains (F) oil.

[0046] Cosmetic according to Plan 9: The mass ratio of the above-mentioned component (D) to the total mass of the cosmetic is 0.1% by mass or more and 0.5% by mass or less.

[0047] Cosmetic according to Plan 10: The cosmetic according to any one of Plans 1 to 7 is a cream, sunscreen, foundation, lotion or beauty liquid.

[0048] Effects of the Invention

[0049] According to the present invention, there is provided a cosmetic having a whitening effect and being stable. The cosmetic of the present invention is suitable for use as, for example, a whitening cream. Detailed Embodiments

[0050] Cosmetic

[0051] The cosmetic of the present invention contains:

[0052] (A) Polyglycerol fatty acid ester surfactants (hereinafter sometimes simply referred to as "fatty acid ester surfactants");

[0053] (B) Aliphatic alcohols having 8 to 40 carbon atoms (hereinafter sometimes simply referred to as "aliphatic alcohols");

[0054] (C) One or more selected from the compounds represented by the above general formula (1) and their pharmacologically acceptable salts (hereinafter sometimes collectively referred to as "pyrimidylpyrazole compounds");

[0055] (D) A thickener having the structure represented by the above general formula (2) (hereinafter sometimes referred to as "AMPS thickener"); and

[0056] (E) Water.

[0057] In addition to the components (A) to (E) above, the cosmetic of the present invention may further contain (F) an oil component.

[0058] The present inventors have conducted a detailed study on the phenomenon of the destruction of the uniform state of a cosmetic when a pyrimidylpyrazole compound is mixed in a cosmetic containing a polyglycerol fatty acid ester and a higher alcohol.

[0059] For a uniform cosmetic, it can be considered that, for example, a surfactant (such as polyglycerol fatty acid ester) and a higher alcohol form a laminated structure of a bimolecular film, water is enclosed between the hydrophilic groups of the laminated structure, and a network is formed in the water to become a gel state, presenting a uniform appearance. When an oil component is included together with the surfactant and the higher alcohol, the oil component is emulsified in the above gel to form a uniform oil-in-water type emulsified state called "α-gel".

[0060] A cosmetic containing an α-gel structure has the advantage that the feeling of use can be appropriately adjusted within a wide range from a refreshing feeling to a slightly thick feeling of use.

[0061] However, if a pyrimidylpyrazole compound is further mixed in the α-gel state cosmetic, it is presumed that the pyrimidylpyrazole compound acts on the laminated structure of the bimolecular film, the laminated structure is destroyed, and thus the uniform state of the cosmetic is destroyed.

[0062] The present inventors have found that if an AMPS thickener is added to a cosmetic containing a polyglycerol fatty acid ester and a higher alcohol, even if a pyrimidylpyrazole compound is further mixed, the uniform state of the cosmetic is not destroyed and the α-gel state is maintained, thus completing the present invention.

[0063] The reason for maintaining the uniform state of the cosmetic even when mixing pyrimidinyl pyrazole compounds by adding the above thickeners is not clear, but it is speculated that this is because the structure of taurine derived from the AMPS thickener blocks the action of pyrimidinyl pyrazole compounds on the stacked structure of the bilayer membrane.

[0064] However, the present invention is not bound by a specific theory.

[0065] Hereinafter, the elements constituting the cosmetic of the present invention will be described in turn.

[0066] 《(A) Polyglycerol fatty acid ester surfactants》

[0067] The component (A) in the cosmetic of the present invention is a polyglycerol fatty acid ester surfactant. The (A) fatty acid ester surfactant is mixed in the cosmetic of the present invention in order to form a stacked structure of a bilayer membrane together with the aliphatic alcohol (B) described later, enclose water between the hydrophilic groups of the stacked structure, and make the cosmetic in a uniform gel state.

[0068] (A) The fatty acid ester surfactant may be a compound formed by ester-bonding a fatty acid to a single terminal or both terminals of polyglycerol.

[0069] The degree of polymerization of polyglycerol may be 4 or more, 5 or more, 6 or more, or 8 or more, and may be 20 or less, 18 or less, 15 or less, or 12 or less.

[0070] The number of carbon atoms of the fatty acid may be 6 or more, 8 or more, 10 or more, 12 or more, 14 or more, or 16 or more, and may be 24 or less, 22 or less, 20 or less, 18 or less, 15 or less, 12 or less, or 10 or less. The number of carbon atoms of the fatty acid is the number of carbon atoms including the carboxyl group.

[0071] The fatty acid may be a saturated fatty acid or an unsaturated fatty acid. In addition, the alkyl group of the fatty acid may be straight-chain or branched-chain. In one embodiment of the present invention, the alkyl group of the fatty acid is saturated and straight-chain. In other embodiments of the present invention, the alkyl group of the fatty acid is saturated and branched-chain. In still other further embodiments of the present invention, the alkyl group of the fatty acid is unsaturated and straight-chain. In still other further embodiments of the present invention, the alkyl group of the fatty acid is unsaturated and branched-chain.

[0072] The (A) fatty acid ester surfactant in the cosmetic of the present invention can be, for example, one or more selected from polyglyceryl decanoate-10, polyglyceryl caprylate-6, polyglyceryl laurate-10, polyglyceryl myristate-10, diglyceryl myristate-10, polyglyceryl stearate-10, diglyceryl stearate-10, diglyceryl isostearate-10, etc. It should be noted that in the above, the number attached after the term "polyglyceryl" represents the degree of polymerization of polyglycerol.

[0073] (A) The HLB value of the fatty acid ester surfactant can be 10 or more, 12 or more, 14 or more, or 16 or more, and can be 17 or less, 15 or less, 14 or less, 13 or less, or 12 or less.

[0074] 《(B) Aliphatic alcohol》

[0075] The (B) component in the cosmetic of the present invention is an aliphatic alcohol having 8 to 40 carbon atoms. The (B) aliphatic alcohol is mixed in the cosmetic of the present invention in order to form a laminated structure of a bimolecular film together with the above-mentioned (A) component, enclose water between the hydrophilic groups of the laminated structure, and make the cosmetic in a uniform appearance of a gel state.

[0076] (B) The number of carbon atoms of the aliphatic alcohol is 8 or more, and can be 10 or more, 12 or more, 14 or more, or 16 or more. In addition, the number of carbon atoms is 40 or less, and can be 36 or less, 32 or less, 28 or less, 26 or less, or 24 or less.

[0077] (B) The aliphatic alcohol can be linear or branched. In a certain embodiment of the present invention, the (B) aliphatic alcohol is a saturated linear chain. In other embodiments of the present invention, the (B) aliphatic alcohol is a saturated branched chain. In addition, in still other further embodiments of the present invention, the (B) aliphatic alcohol is an unsaturated linear chain. In still other further embodiments of the present invention, the (B) aliphatic alcohol is an unsaturated branched chain.

[0078] The (B) aliphatic alcohol in the cosmetic of the present invention can be, for example, one or more selected from lauryl alcohol, myristyl alcohol, cetyl alcohol (palmitol), stearyl alcohol, behenyl alcohol, etc. An alcohol that is a mixture of cetyl alcohol and stearyl alcohol and is commercially available as "cetearyl alcohol" can also be used as the (B) aliphatic alcohol in the cosmetic of the present invention.

[0079] 《(C) Pyrimidylpyrazole compounds》

[0080] The (C) component in the cosmetic of the present invention is one or more selected from the compounds represented by the following general formula (1) and their pharmacologically acceptable salts.

[0081]

[0082] (In general formula (1), R1, R3, R4, and R6 are each independently an alkyl group having 1 to 3 carbon atoms, and R2 and R5 are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)

[0083] This (C) pyrimidylpyrazole compound is blended into the cosmetic of the present invention in order to impart a whitening effect to the cosmetic.

[0084] The alkyl group having 1 to 3 carbon atoms of R1 to R6 may be, for example, methyl, ethyl, n-propyl, isopropyl, or cyclopropyl, particularly may be methyl or ethyl, and typically may be methyl.

[0085] In a certain embodiment of the present invention, R1, R3, R4, and R6 in the above general formula (1) are all methyl. In other embodiments of the present invention, R2 and R5 in the above general formula (1) are both hydrogen atoms. In still other embodiments of the present invention, R1, R3, R4, and R6 in the above general formula (1) are all methyl, and R2 and R5 are both hydrogen atoms.

[0086] In a certain embodiment of the present invention, R1, R2, R3, R4, and R6 in the above general formula (1) are all methyl. In other embodiments of the present invention, R5 in the above general formula (1) is a hydrogen atom. In still other embodiments of the present invention, R1, R2, R3, R4, and R6 in the above general formula (1) are all methyl, and R5 is a hydrogen atom.

[0087] In a certain embodiment of the present invention, R2 and R5 in the above general formula (1) are both ethyl. In other embodiments of the present invention, R1, R2, R3, R4, and R6 in the above general formula (1) are all methyl, and R2 and R5 are both ethyl atoms.

[0088] The component (B) in the present invention may be selected from

[0089] 2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine,

[0090] 2-(3,5-dimethylpyrazol-1-yl)-4,5,6-trimethylpyrimidine, and

[0091] 5-ethyl-2-(4-ethyl-3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine, and

[0092] pharmacologically acceptable salts thereof

[0093] one or more compounds selected from the group consisting of

[0094] The pharmacologically acceptable salts of the compounds represented by the above general formula (1) may be, for example, acid addition salts of the compounds represented by the above general formula (1), and the acids in the acid addition salts may be inorganic acids or organic acids. The inorganic acids may be, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, etc., and the organic acids may be, for example, acetic acid, propionic acid, citric acid, lactic acid, oxalic acid, maleic acid, fumaric acid, succinic acid, tartaric acid, methanesulfonic acid, etc.

[0095] The compounds represented by the above general formula (1) can be synthesized by known methods and can also be obtained as commercially available products. Representative synthesis methods of the compounds represented by the above general formula (1) are disclosed, for example, in the above Patent Document 2.

[0096] 《(D) AMPS Thickener》

[0097] The (D) component in the cosmetic of the present invention is a thickener (AMPS thickener) having a structure represented by the following general formula (2).

[0098]

[0099] (In the general formula (2), R7 and R8 are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)

[0100] It is considered that the (D) AMPS thickener has the function of stably maintaining the laminated structure of the bimolecular film formed by the above (A) fatty acid ester surfactant and (B) aliphatic alcohol in a wide pH range. In addition, by blending the (D) AMPS thickener in the cosmetic, a refreshing feeling can be obtained.

[0101] The alkyl groups having 1 to 3 carbon atoms of R7 and R8 in the above general formula (2) can each independently be methyl, ethyl, n-propyl or isopropyl. In a certain embodiment of the present invention, both R7 and R8 in the general formula (2) are methyl.

[0102] The (D) AMPS thickener in the cosmetic of the present invention may be, for example,

[0103] Copolymer of acryloyldimethyltaurine ammonium and N-vinylpyrrolidone,

[0104] Copolymer of sodium acryloyldimethyltaurate, dimethylacrylamide and methylenebisacrylamide,

[0105] (Acrylamide / sodium acryloyldimethyltaurate) copolymer,

[0106] (Dimethylacrylamide / sodium acryloyldimethyltaurate) crosslinked polymer,

[0107] (2-Hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer,

[0108] (Sodium acrylate / sodium acryloyldimethyltaurate) copolymer

[0109] (Ammonium acryloyldimethyltaurate / polyoxyethylene behenyl ether-25 methacrylate) cross-linked polymer

[0110] (Sodium acrylate / sodium acryloyldimethyltaurate / dimethylacrylamide) cross-linked polymer

[0111] etc., and one or more than two kinds selected from them can be used.

[0112] "(E) Water"

[0113] The cosmetic of the present invention contains water as a solvent.

[0114] "(F) Oil component"

[0115] In addition to the above components (A) to (E), the cosmetic of the present invention may further contain (F) oil component. As the (F) oil component, an oil component commonly used in the fields of cosmetics, pharmaceuticals, etc. can be appropriately selected and used.

[0116] (F) The oil component can be selected and used from a solid oil component that is solid at room temperature (25 °C) and a liquid oil component that is liquid at this temperature.

[0117] As the solid oil component, for example, solid fats such as cocoa butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, hydrogenated palm oil, beef tallow, mutton fat, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, wood wax kernel oil, hardened fat, beef foot fat, wood wax, hydrogenated castor oil, etc.; waxes such as beeswax, candelilla wax, cotton wax, carnauba wax, myrica wax, insect wax, spermaceti wax, lignite wax, rice bran wax, lanolin, kapok wax, acetylated lanolin, sugarcane wax, isopropyl lanolate, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, lac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, POE hydrogenated lanolin alcohol ether, etc.; hydrocarbon waxes such as polyethylene wax, paraffin wax, pure ozokerite, petrolatum, microcrystalline wax,ルナセラ, ceresin, etc.; fatty acid glycerol ethers such as monostearyl glycerol ether (batyl alcohol); fatty acid glycerides such as acetyl glyceride, tri-2-heptylundecanoin, etc., and one or more than two kinds selected from them can be used.

[0118] As the liquid oil component, liquid fats, ester oils, hydrocarbon oils, silicone oils, etc. can be cited, and one or more than two kinds selected from them can be used.

[0119] As liquid oils and fats, for example, avocado oil, evening primrose oil, camellia oil, turtle oil, macadamia nut oil, sunflower oil, almond oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, peach kernel oil, wheat germ oil, camellia flower oil, sugar squalane, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, torreya seed oil, rice bran oil, white tung oil, Japanese tung oil, jojoba seed oil, germ oil, etc. can be mentioned, and one or more kinds selected from them can be used.

[0120] As ester oils, for example, cetyl octanoate, cetyl 2-ethylhexanoate, hexyl decyl dimethyl octanoate, ethyl laurate, hexyl laurate, isopropyl myristate, 2-hexyldecyl myristate, myristyl myristate, octyldodecyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, butyl stearate, isocetyl stearate, isocetyl isostearate, decyl oleate, dodecyl oleate, oleyl oleate, myristyl lactate, cetyl lactate, diisostearyl malate, cholesteryl 12-hydroxystearate, methyl ricinoleate, 2-octyldodecyl N-lauroyl-L-glutamate, 2-ethylhexyl succinate, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl ethylhexanoate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol didecanoate, neopentyl glycol dioctanoate, acetyl glyceride, glycerol di-2-heptylundecanoate, glycerol trioctanoate, glycerol trioctanoate, glycerol tri-2-ethylhexanoate, glycerol trimyristate, glycerol tripalmitoleate, glycerol tri-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetraoctanoate, pentaerythritol tetraethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, etc. can be mentioned, and one or more kinds selected from them can be used.

[0121] As hydrocarbon oils, for example, liquid paraffin, ozokerite, squalene, pristane, polybutene, hydrogenated polybutene, etc. can be mentioned, and one or more kinds selected from them can be used.

[0122] As silicone oils, for example, linear polysiloxanes such as dimethylpolysiloxane (also called "polydimethylsiloxane"), methylphenylpolysiloxane, diphenylpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc. can be mentioned, and one or more kinds selected from them can be used.

[0123] 《Other Components》

[0124] In addition to the above components (A) to (E) and the optional component (F), the cosmetic of the present invention may further contain other components.

[0125] Examples of other components include surfactants other than component (A), thickeners other than component (D), moisturizers, defoamers, cooling agents, pH adjusters, chelating agents, preservatives, antioxidants, pigments, fragrances, stabilizers, etc.

[0126] 《Mixing amounts of each component》

[0127] Regarding the mixing amount of the (A) fatty acid ester surfactant in the cosmetic of the present invention, as the mass ratio of the (A) fatty acid ester surfactant to the total mass of the cosmetic, it can be 1.0% by mass or more, 1.5% by mass or more, 2.0% by mass or more, or 2.5% by mass or more, and can be 10.0% by mass or less, 8.0% by mass or less, 6.0% by mass or less, 5.0% by mass or less, 4.0% by mass or less, or 3.0% by mass or less.

[0128] Regarding the mixing amount of the (B) aliphatic alcohol in the cosmetic of the present invention, as the mass ratio of the (B) aliphatic alcohol to the total mass of the cosmetic, it can be 0.5% by mass or more, 1.0% by mass or more, 1.5% by mass or more, 2.0% by mass or more, or 2.5% by mass or more, and can be 12.0% by mass or less, 10.0% by mass or less, 8.0% by mass or less, 6.0% by mass or less, 5.0% by mass or less, or 4.0% by mass or less.

[0129] Furthermore, in the cosmetic of the present invention, regarding the mixing ratio of the (A) fatty acid ester surfactant and the (B) aliphatic alcohol, as the mass ratio of the (B) aliphatic alcohol to the total mass of the two, it can be 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, 30% by mass or more, 40% by mass or more, or 50% by mass or more, and can be 75% by mass or less, 70% by mass or less, 65% by mass or less, 60% by mass or less, 55% by mass or less, or 50% by mass or less.

[0130] Regarding the mixing amount of the (C) pyrimidinylpyrazole compounds in the cosmetic of the present invention, as the mass ratio of the (C) pyrimidinylpyrazole compounds to the total mass of the cosmetic, it can be 0.05% by mass or more, 0.10% by mass or more, 0.15% by mass or more, 0.20% by mass or more, or 0.25% by mass or more, and can be 1.0% by mass or less, 0.8% by mass or less, 0.6% by mass or less, 0.5% by mass or less, or 0.4% by mass or less.

[0131] Regarding the blending amount of the (D) AMPS thickener in the cosmetic of the present invention, as the mass ratio of the (D) AMPS thickener to the total mass of the cosmetic, it can be 0.01% by mass or more, 0.03% by mass or more, 0.05% by mass or more, 0.07% by mass or more, 0.08% by mass or more, or 0.1% by mass or more, and can be 1.0% by mass or less, 0.8% by mass or less, 0.6% by mass or less, 0.5% by mass or less, or 0.3% by mass or less.

[0132] In addition, in the cosmetic of the present invention, the blending ratio of the (D) AMPS thickener to the total mass of the (A) fatty acid ester surfactant and the (B) aliphatic alcohol can be 0.1% by mass or more, 0.3% by mass or more, 0.5% by mass or more, 1.0% by mass or more, 1.5% by mass or more, or 2.0% by mass or more, and can be 12% by mass or less, 10% by mass or less, 8% by mass or less, 6% by mass or less, 5% by mass or less, 4% by mass or less, or 3% by mass or less.

[0133] When the cosmetic of the present invention contains the (F) oil component, regarding its blending amount, as the mass ratio of the (F) oil component to the total mass of the cosmetic, it can be 5% by mass or more, 10% by mass or more, 12% by mass or more, or 15% by mass or more, and can be 35% by mass or less, 30% by mass or less, 28% by mass or less, 25% by mass or less, 23% by mass or less, or 20% by mass or less.

[0134] 《pH of Cosmetic》

[0135] The pH of the present invention can be in the range of 4 or more and 8 or less.

[0136] 《Method for Manufacturing Cosmetic》

[0137] The cosmetic of the present invention can be manufactured by mixing the respective components of (A) to (E), the (F) component as an optional component, and other components to be blended as needed by an appropriate method. The temperature during mixing is, for example, 50°C or more and less than 100°C, preferably 60°C or more and 90°C or less.

[0138] When the cosmetic of the present invention contains optional components other than the components of (A) to (F), such as moisturizers, defoamers, cooling agents, pH adjusters, chelating agents, preservatives, antioxidants, pigments, fragrances, stabilizers, etc., the cosmetic of the present invention can be, for example, by

[0139] An emulsion phase composed of the respective components of (A) to (D) and (F), and

[0140] The main aqueous phase composed of the above-mentioned optional components and the remaining part of the (E) component

[0141] After separately modulating them, a method of mixing the two is used for modulation.

[0142] In this case, the temperature when mixing the components of the emulsion phase, the temperature when mixing the components of the main aqueous phase, and the temperature when mixing the emulsion phase and the main aqueous phase are all, for example, 50°C or higher and less than 100°C, preferably 60°C or higher and 90°C or lower.

[0143] "Use of Cosmetics"

[0144] The cosmetics of the present invention can be cosmetics for humans, and the product form is also arbitrary. The cosmetics of the present invention can be in appropriate forms such as, for example, cream, emulsified, lotion, etc.

[0145] The cosmetics of the present invention can be suitably applied to, for example, creams (such as skin creams), sunscreens (such as sunscreen lotions), foundations (such as emulsified foundations), lotions, beauty essences, etc.

[0146] Examples

[0147] Cosmetics described in Tables 1 to 3 below were manufactured and evaluated for stability. The manufacturing method and evaluation method of the cosmetics are as described below respectively.

[0148] "Cosmetic Modulation Method"

[0149] The cosmetics of each reference example, each comparative example, and each example were modulated as follows. First, ion-exchanged water (a part of component (E)), and the glycerol fatty acid esters (component (A) or other glycerol fatty acid esters), component (B), component (C), thickener (component (D) or other thickeners), and component (F) described in Tables 1 to 3 were mixed at 70 to 80°C to prepare an emulsion phase. In addition, ion-exchanged water (the remaining part of component (E)) and the main aqueous phase components described in Tables 1 to 3 were mixed at 70 to 80°C to prepare the main aqueous phase.

[0150] Next, while maintaining the liquid temperature at 70 to 80°C, the main aqueous phase was added to the emulsion phase and mixed, and then cooled to room temperature to obtain the cosmetics.

[0151] "Cosmetic Evaluation Method"

[0152] The obtained cosmetics were sealed in sample bottles and left standing at 60°C for 5 days (120 hours). The cosmetics after standing for 5 days were visually observed and evaluated according to the following criteria.

[0153] A: The case where the aqueous phase and the oil phase do not separate and there is no complete separation of the emulsion (extremely good)

[0154] B: The aqueous phase and the oil phase do not separate, and very little emulsion stratification is observed (good).

[0155] C: Although the aqueous phase and the oil phase do not separate, emulsion stratification is observed (slightly poor).

[0156] D: The case where the aqueous phase and the oil phase are separated (poor).

[0157]

[0158]

[0159]

[0160] The blending amounts of the respective components in Tables 1 to 3 are in units of "mass %". The so-called "compound (C-1)" of component (C) means "2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine hydrochloride". In addition, the so-called blending amount of component (E) (ion-exchanged water) being "residual" means that the total blending amount of component (E) (ion-exchanged water) is appropriately changed so that the total amount of each cosmetic is 100 mass %.

[0161] As observed in Table 1, the cosmetic of Reference Example 1 without the (C) pyrimidylpyrazole compound showed excellent stability even after standing at 60 °C for 5 days. Similarly, for the cosmetics of Reference Examples 2 to 5 in which a thickener was further blended in the cosmetic of Reference Example 1, excellent stability was also shown after standing at 60 °C for 5 days.

[0162] However, as observed in Table 2, for the cosmetic of Comparative Example 1 in which the (C) pyrimidylpyrazole compound was blended in the cosmetic of Reference Example 1, separation of the aqueous phase and the oil phase was observed after standing at 60 °C for 5 days.

[0163] In addition, as observed in Table 2, for the cosmetics of Comparative Examples 2 to 5 in which a thickener different from component (D) specified in the present invention was blended in the cosmetic of Comparative Example 1, there was no improvement effect on the stability after standing at 60 °C for 5 days, or if any, it was extremely small.

[0164] In contrast, as observed in Table 3, for the cosmetics of Examples 1 to 3 in which a thickener as component (D) specified in the present invention was blended in the cosmetic of Comparative Example 1, it was confirmed that the stability after standing at 60 °C for 5 days was improved.

Claims

1. A cosmetic, comprising: (A) A polyglycerol fatty acid ester surfactant; (B) An aliphatic alcohol having 8 to 40 carbon atoms; (C) One or more selected from the compounds represented by the following general formula (1) and their pharmacologically acceptable salts; (D) A thickener having the structure represented by the following general formula (2); and (E) Water, In general formula (1), R1, R3, R4, and R6 are each independently an alkyl group having 1 to 3 carbon atoms, and R2 and R5 are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms. In general formula (2), R7 and R8 are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.

2. The cosmetic according to claim 1, wherein R7 and R8 in general formula (2) are methyl groups.

3. The cosmetic according to claim 2, wherein the component (D) is selected from a copolymer of acryloyldimethyltaurine ammonium and N-vinylpyrrolidone, and a copolymer of acryloyldimethyltaurine sodium, dimethylacrylamide, and methylenebisacrylamide one or more.

4. The cosmetic according to claim 1, wherein the HLB value of the component (A) is 10 or more and 17 or less.

5. The cosmetic according to claim 1, wherein the component (C) is selected from a compound in which R1, R3, R4, and R6 in general formula (1) are methyl groups, and R2 and R5 are hydrogen atoms, a compound in which R1, R2, R3, R4, and R6 in general formula (1) are methyl groups, and R5 is a hydrogen atom, and a compound in which R1, R3, R4, and R6 in general formula (1) are methyl groups, and R2 and R5 are ethyl groups one or more.

6. The cosmetic according to claim 2, wherein the component (C) is selected from a compound in which R1, R3, R4, and R6 in general formula (1) are methyl groups, and R2 and R5 are hydrogen atoms, a compound in which R1, R2, R3, R4, and R6 in general formula (1) are methyl groups, and R5 is a hydrogen atom, and a compound in which R1, R3, R4, and R6 in general formula (1) are methyl groups, and R2 and R5 are ethyl groups one or more.

7. The cosmetic according to claim 3, wherein the component (C) is selected from a compound in which R1, R3, R4, and R6 in general formula (1) are methyl groups, and R2 and R5 are hydrogen atoms, a compound in which R1, R2, R3, R4, and R6 in general formula (1) are methyl groups, and R5 is a hydrogen atom, and a compound in which R1, R3, R4, and R6 in general formula (1) are methyl groups, and R2 and R5 are ethyl groups one or more.

8. The cosmetic according to any one of claims 1 to 7, further comprising (F) an oil component.

9. The cosmetic according to any one of claims 1 to 7, wherein the mass ratio of the component (D) to the total mass of the cosmetic is 0.1% by mass or more and 0.5% by mass or less.

10. The cosmetic according to any one of claims 1 to 7, which is a cream, sunscreen, foundation, lotion, or beauty liquid.

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