Hair composition containing selenium disulfide inclusion

Abstract

The invention belongs to the field of daily chemicals, and particularly relates to a hair composition containing a selenium disulfide inclusion. The hair composition containing the selenium disulfide inclusion is characterized by comprising the following raw materials in percentage by weight: 0.2-2.0% of the selenium disulfide inclusion, 0.5-2.0% of the selenium disulfide inclusion and the balance of water. 8%-20% of an anionic surfactant; 0.5%-6% of an ampholytic surfactant; 0.5%-2% of a nonionic surfactant; 0.5%-10% of a liquid crystal phase induction structuring agent; 0.2%-0.8% of cationic polysaccharide; 0.05%-5% of a non-volatile conditioner; and the balance of pure water. The hair composition provided by the invention has the advantages of low irritation, good anti-dandruff effect, good anti-dandruff durability and good foam stability.

Description

Technical Field

[0001] The present invention belongs to the field of daily chemicals, and particularly relates to a hair care composition containing selenium disulfide inclusions. Background Art

[0002] Dandruff is the product of the metabolism of epidermal cells on the human head. The normal death and shedding of epidermal cells is a natural and normal physiological process. Under healthy conditions, this metabolic process usually takes about 28 days to complete. However, the presence of Malassezia disrupts this balance. According to relevant literature reports, Malassezia lives on the saturated fatty acids decomposed from sebum, and the remaining unsaturated fatty acids will penetrate into the scalp, thereby triggering an inflammatory response in the human body. When inflammation occurs, the proliferation of scalp cells will accelerate abnormally, and the moving speed of cells towards the scalp surface will also increase abnormally, ultimately resulting in large-scale shedding of surface cells, forming visible dandruff. The problem of dandruff has become the second largest hair health problem that plagues consumers after hair loss. In view of this, the market share of anti-dandruff shampoos has accounted for more than 35% of the total shampoo market. Although anti-dandruff products emerge in an endless stream, about 70% of the people using anti-dandruff products think that the effects of these products are not ideal.

[0003] At present, the antidandruff agents commonly used in antidandruff shampoo and other antidandruff products on the market include OCT (pyridone ethanolamine salt), ZPT (pyrithione copper zinc), HP100 (hexamidine di (hydroxyethyl sulfonate) salt), climbazole (climbazole), Runanti HS (bispyrithione), SL-900 (undecylenamide MEA disodium sulfosuccinate), salicylic acid, etc. However, each of these antidandruff agents has obvious disadvantages. For example, salicylic acid only has a bactericidal effect, and its anti-dandruff effect is poor. In addition, it is highly irritating and can easily damage the scalp. ZPT can be used to prepare opaque shampoos, which have good anti-dandruff and antipruritic effects, but it is easy to change color when it encounters iron ions, has a high price, and has been banned from use in cosmetics by the EU since March 2022 due to its reproductive toxicity. Climbazole has an inhibitory effect on spore-forming bacteria or pityriasis ovale, Candida albicans, and Trichophyton, which cause dandruff, but its anti-dandruff and antipruritic effects are not very obvious, and it is harmful to aquatic organisms and may pollute the aquatic environment. Undecene derivatives have mild effects and good water solubility, but when used, special attention should be paid to the compatibility with some cationic conditioners in the formula to prevent precipitation. The above anti-dandruff agents generally have problems such as high toxicity, poor solubility, or poor anti-dandruff effect. In addition, ketofuranazole is an anti-dandruff and antipruritic agent approved by the US FDA in 1992 for use in shampoo. It has a good anti-dandruff effect, but it is an antifungal drug and is listed as a prohibited raw material for cosmetics in my country. Moreover, although intermittent use of these antidandruff agents can effectively inhibit the growth of bacteria and fungi, long-term use can easily cause skin irritation, allergies and other problems. While killing bacteria, they also cause serious damage to the scalp sebum. Not only do they fail to achieve the goal of curing dandruff, but they make dandruff more likely to recur. In addition, there are some compatibility issues in actual formulation applications.

[0004] Selenium disulfide is a low-toxic and highly effective anti-dandruff raw material. The "China Cosmetics Hygiene Standard" (2015 edition) clearly stipulates that the limit of its use in hair rinse products is 1%. The relevant toxicological data summarized by the European Chemicals Agency (ECHA) show that the acute oral LD50 value of selenium disulfide for female Crl:WI Wistar rats is between 300 and 2000 mg / kg. According to Regulation (EC) No1272 / 2008, it can be classified as "Category 4" for acute oral exposure. In vitro skin corrosion tests conducted in a reconstructed human epidermal model showed that selenium disulfide is non-corrosive to the skin; in vitro eye irritation tests on isolated chicken eyes also concluded that selenium disulfide is non-irritating; in Salmonella typhimurium and Escherichia coli reverse mutation tests, selenium disulfide is considered to be non-mutagenic. Based on the evaluation of these toxicological data, from the perspective of safety, selenium disulfide is a more preferred type of anti-dandruff agent. It has the effects of anti-seborrhea, inhibiting the reproduction of Malassezia, and resisting epidermal hyperplasia, and has a good therapeutic effect on dandruff and seborrheic dermatitis of the scalp.

[0005] However, selenium disulfide has some significant defects and deficiencies in practical applications. Firstly, selenium disulfide is a water-insoluble solid with a large density, and its particle size is uneven. If the suspension ability of the system is poor, larger particles are likely to sink; if the rheological properties of the system are unstable and the viscosity of the material becomes thinner, selenium disulfide will agglomerate and settle to the bottom, resulting in the instability of the selenium disulfide suspension system, and further causing the product to delaminate, which seriously affects the appearance and use effect of the product. Secondly, selenium disulfide will undergo an oxidation reaction and change color in an overly acidic or overly alkaline environment, and it will also be affected by heat or light and change color. These two major problems, namely discoloration and flocculation, greatly limit the application and promotion of selenium disulfide.

[0006] Regarding the problems of selenium disulfide, some related patents have proposed solutions. Patent CN105456287A discloses selenium disulfide ultrafine powder and its preparation method. This invention solves the problems of long production time when preparing selenium disulfide ultrafine powder as a lotion by medium ball milling, as well as the quality problems of large selenium disulfide particles, uneven dispersion, and instability. However, this preparation method only targets selenium disulfide powder and does not provide a solution to the discoloration problem during the process of selenium disulfide fluid and fluid grinding. Patent CN111544332A suspends selenium disulfide by using an acrylic acid (ester) copolymer as a suspending agent. This copolymer is transformed into a salt by neutralization, and the mutual repulsion of like charges makes the molecules straighten to form an open structure. However, it has poor salt tolerance and is easily affected by ions in the formulation. Under neutral conditions, the few anionic charges on the thickener will be shielded by heteroionic ions, resulting in a significant weakening of the electrostatic repulsion between thickeners, a strong curling of the molecular chains, the formation of small and dense grids, and a significant reduction in both the "holding" and "preserving" water amounts, thereby causing the system to collapse rapidly and the viscosity to drop sharply. Therefore, it is necessary to avoid the presence of excessive ions in formulating the formulation to prevent the destruction of the thickener structure, and this system has certain limitations. Patent CN116421479A provides a composition containing a layered surfactant phase, a spherical granular double surfactant phase, or both coexisting, forming a liquid crystal phase with a closely packed three-dimensional structure, showing anisotropy and non-Newtonian fluid characteristics, thus improving the suspension stability of selenium disulfide. Compared with traditional carbopol suspension, its suspension ability is not affected by electrolytes and can maintain good suspension ability within a wide pH range. However, a single "suspension technology" cannot solve the problems of selenium disulfide agglomeration and sedimentation as well as oxidation and discoloration. Patent CN118436555A discloses a preparation method of selenium disulfide encapsulated by chitosan quaternary ammonium salt. By encapsulating selenium disulfide with chitosan quaternary ammonium salt and applying the obtained product to shampoo, the problem of insolubility of selenium disulfide in water is solved, and the dosage can be reduced, the cost can be lowered, and scalp irritation can be reduced. However, the quaternary ammonium salt chitosan on the market is generally a non-long carbon chain quaternary ammonium salt chitosan product quaternized with trimethyl ammonium chloride, which does not meet the requirements of this patent as a carrier for encapsulating selenium disulfide. Therefore, this technology has a complex production process, is difficult to mass-produce, and the carrier material is expensive. Moreover, in terms of the application of selenium disulfide in products, this technology only provides an "encapsulation" technology, does not involve the problem of unstable suspension of selenium disulfide, and does not provide a solution to the discoloration problem of selenium disulfide products.

[0007] In summary, under the condition of limited selenium disulfide dosage, it is of great practical significance to develop a mild composition containing selenium disulfide that can remove dandruff persistently and enable it to be stably applied in hair cleansing products. Summary of the Invention

[0008] The technical problem to be solved by the present invention is to provide a hair care composition containing selenium disulfide inclusions, which has low irritation, good anti-dandruff effect and good anti-dandruff persistence, and at the same time has good foam stability.

[0009] The technical solution adopted by the present invention to solve the above problems is as follows:

[0010] A hair care composition containing selenium disulfide inclusions, comprising the following raw materials by weight percentage:

[0011] (A) Selenium disulfide inclusions 0.2% - 2.0%;

[0012] (B) Anionic surfactant 8% - 20%;

[0013] (C) Amphoteric surfactant 0.5% - 6%;

[0014] (D) Nonionic surfactant 0.5% - 2%;

[0015] (E) Liquid crystal phase-induced structuring agent 0.5% - 10%;

[0016] (F) Cationic polysaccharide 0.2% - 0.8%;

[0017] (G) Non-volatile conditioner 0.05% - 5%;

[0018] And the balance of

[0019] (H) Pure water.

[0020] Preferably, the selenium disulfide inclusions are formed by encapsulating selenium disulfide with cyclodextrin as a carrier.

[0021] Preferably, the selenium disulfide inclusions are obtained by dissolving cyclodextrin in deionized water to form a solution, mixing and dispersing selenium disulfide powder with a dispersant to form a suspension; then mixing the solution and the suspension and grinding them in a grinder, and finally subjecting them to a drying treatment.

[0022] Specifically, the preparation method of the selenium disulfide inclusions comprises the following steps:

[0023] S1. Mix cyclodextrin and deionized water evenly to obtain a cyclodextrin solution;

[0024] S2. Disperse selenium disulfide powder and a dispersant evenly to obtain a selenium disulfide suspension;

[0025] S3. Mix the cyclodextrin solution and the selenium disulfide suspension and grind them in a grinder to obtain a mixed product;

[0026] S4. Subject the mixed product to a drying treatment to obtain selenium disulfide inclusions.

[0027] Preferably, the mass ratio of the cyclodextrin to the deionized water is 1:1 to 5.

[0028] More preferably, the mass ratio of the cyclodextrin to the deionized water is 1:3 to 5.

[0029] Preferably, the mass ratio of the selenium disulfide powder to the dispersant is 1:1 to 6.

[0030] More preferably, the mass ratio of the selenium disulfide powder to the dispersant is 1:2 to 3.

[0031] Preferably, the particle size of the selenium disulfide powder is 500 to 5000 nm.

[0032] More preferably, the particle size of the selenium disulfide powder is 420 to 770 nm. In order to make selenium disulfide more easily dispersed in the shampoo formulation and reduce the risk of coagulation, the particle size of selenium disulfide should be moderate and evenly dispersed.

[0033] Most preferably, the particle size of the selenium disulfide powder is 537.02 nm.

[0034] Preferably, the dispersant is at least one of polyols, N-acyl amino acid surfactant solution, alkyl betaine surfactant solution, and sulfobetaine surfactant solution.

[0035] Preferably, the polyol is at least one of glycerol, propylene glycol, butylene glycol, and sorbitol.

[0036] More preferably, the dispersant is glycerol.

[0037] Preferably, the mass ratio of the cyclodextrin to the selenium disulfide powder is (1 to 5):(1 to 2).

[0038] More preferably, the mass ratio of the cyclodextrin to the selenium disulfide powder is 1:1. In the final product of selenium disulfide inclusion obtained at this mass ratio, the selenium disulfide content is 40%.

[0039] Preferably, in step S3, the grinding time is 0.5 to 1.5 h. The ground product gradually becomes viscous and pasty.

[0040] Preferably, the structural formula of the anionic surfactant is as follows:

[0041] RO(C2H4O) n SO3 - M + ;

[0042] Among them, R is an alkyl group with 8 - 18 carbon atoms, n is the degree of ethoxylation, n is an integer greater than or equal to zero, and M is a monovalent cation.

[0043] More preferably, the R is an alkyl group with 12 - 14 carbon atoms.

[0044] Specifically, the anionic surfactants applicable to the present invention include: alkyl alcohol sulfates, alkyl alcohol polyether sulfates, alkyl - aryl sulfonates, sulfosuccinates, acyl taurates, acyl amino acid salts, etc. As the commonly used anionic surfactants in the present invention, it includes: one or two of alkyl polyoxyethylene ether sulfates, fatty acid monoglyceride sulfates, fatty alcohol ether sulfosuccinate salts, N - acyl amino acid salts, acyl methyl taurates, acyl methyl taurine taurates. Such anionic surfactants have a relatively large critical packing parameter. Especially when compounded with N - acyl amino acid surfactants, surfactants with a large critical packing parameter help to reduce the irritation of the overall system.

[0045] Specifically, the amphoteric surfactants applicable to the present invention include: alkyl betaines, acyl ethylenediamine derivatives, sulfobetaines, etc. As the commonly used amphoteric surfactants in the present invention, it includes at least one of coconut oil amide propyl betaine, coconut oil amide propyl hydroxy sulfobetaine, lauroyl amphoacetate sodium, coconut oil acyl amphoacetate sodium, lauroyl amphodiacetate sodium, coconut oil acyl amphodiacetate sodium.

[0046] Preferably, the amphoteric surfactant is alkyl amide propyl betaine, and its content is 2% - 6%.

[0047] More preferably, the content of the amphoteric surfactant is 3% - 5%.

[0048] Specifically, the non - ionic surfactants applicable to the present invention include: fatty alcohol polyether - n, alkyl polyglycosides, ethoxylated oils and fats, alkyl alcohol amides, lipids, PEG - n glycerol fatty acid esters, alkyl amine oxides, lipids, etc. Adding non - ionic surfactants is beneficial to the formation of liquid crystal phase - induced structuring agents.

[0049] Preferably, the non - ionic surfactants include coconut oil amide MEA and coconut oil amide methyl MEA. The content of coconut oil amide MEA is 1% - 2%, and the content of coconut oil amide methyl MEA is 0.5% - 1%.

[0050] Preferably, the liquid crystal phase-inducing structurant comprises fatty alcohol and trimethylol stearin. Adding a certain amount of the liquid crystal phase-inducing structurant is sufficient to promote the formation of such a liquid crystal phase-inducing structurant system together with the surfactant, that is, the composition exhibits shear-thinning rheological properties and can suspend water-insoluble or partially water-soluble components. The liquid crystal phase-inducing structurant can be added to the components alone or incorporated with other substances. Some compounds with long-chain alkyl groups can dissolve in the formulation components at high temperatures, but when cooled to room temperature, they crystallize to form a network structure, having rheological properties similar to those of a solid at rest. When the force generated during pouring the composition exceeds the yield stress, the composition can be in a flowing state. Compared with carbomer-based suspending agents, the liquid crystal phase-inducing structurant system is not affected by the ions in the formulation and does not affect the conditioning performance of the shampoo. The crystallization to form a network structure gives the shampoo a certain suspending effect, suspending selenium disulfide and stabilizing it in the formulation system.

[0051] Preferably, the carbon chain of the fatty alcohol has 12 to 22 carbon atoms. More preferably, the carbon chain of the fatty alcohol has 16 to 18 carbon atoms.

[0052] Preferably, the mass ratio of the fatty alcohol to the trimethylol stearin is 5 to 8:3 to 8.

[0053] Preferably, the cationic polysaccharide includes polyquaternium-10, polyquaternium-67, guar hydroxypropyltrimonium chloride, etc. The hair conditioning composition applicable to the present invention is a cationic polysaccharide, which is mainly some modified glucans and has the unique advantage of tightly binding to human skin proteins (negatively charged) and hair. When the cationic polysaccharide in the shampoo is used in combination with an anionic surfactant, due to the strong electrostatic attraction between positive / negative ions intermolecularly, rod-like micelles are easily formed after mutual blending. When the concentration of the surfactant is lower than the critical micelle concentration (CMC) of the surfactant, insoluble aggregates will be formed. When the surfactant concentration is higher than the CMC, this phase will dissolve again. During the shampooing process, the shampoo is continuously diluted. When diluted below the CMC, the condensed phase will phase-separate and deposit on the hair. The effective components are encapsulated in the condensed phase and act on the hair.

[0054] More preferably, the cationic polysaccharide is a compound prepared by mixing guar hydroxypropyltrimonium chloride and polyquaternium-10 in a mass ratio of 3:1. The applicant unexpectedly found in the present invention that the compound prepared by mixing guar hydroxypropyltrimonium chloride and polyquaternium-10 in a mass ratio of 3:1 can achieve the best flocculation effect. At the same time, through experiments, it was found that this composition has a significant flocculation effect in a wide dilution range, indicating that even when diluted with a large amount of water during the cleaning process, it can still flocculate and lock in the effective substances.

[0055] Preferably, the non-volatile conditioner is one or two of emulsified polysiloxane and amino silicone oil.

[0056] More preferably, the particle sizes of the emulsified polysiloxane and the amino silicone oil are 0.05 μm to 80 μm. The emulsified polysiloxane and amino silicone oil with such particle sizes exist in the composition and are considered effective particulate matters, which have a conditioning effect on hair.

[0057] Most preferably, the particle sizes of the emulsified polysiloxane and the amino silicone oil are 30 μm to 50 μm; the internal phase viscosity of the emulsified polysiloxane is 250,000 cps to 550,000 cps. The selected emulsified polysiloxane has good spreading property and forms a thin film on the hair surface. Compared with the unmodified silicone oil, the selected amino silicone oil has stronger adsorption to hair and gives a certain conditioning effect to the shampoo.

[0058] Preferably, the hair cosmetic composition containing selenium disulfide inclusions further comprises at least one of the following raw materials by weight percentage: humectant 0.1% - 5%; sunscreen agent 0.01% - 5%; preservative 0.01% - 1%; pH regulator 0.001% - 2%; essence 0.01% - 3%; viscosity regulator 0.01% - 4%.

[0059] The preparation method of the above hair cosmetic composition containing selenium disulfide inclusions is conventional preparation and mixing techniques, which will not be described in detail here.

[0060] The present invention has the following beneficial effects:

[0061] In the present invention, selenium disulfide inclusions are prepared by grinding method to make cyclodextrin encapsulate selenium disulfide, adopting the "encapsulation technology". Cyclodextrin is highly hydrophilic, which can reduce the irritation of selenium disulfide in cosmetics to skin and mucous membrane tissues, and assist in suspending and stabilizing the system to improve its stability. This "encapsulation technology" greatly improves the situation that selenium disulfide is easy to oxidize and change color, and has a slow-release effect when encapsulated in cyclodextrin, which can improve the bioavailability and the durability of product efficacy. The process for preparing selenium disulfide inclusions is simple, environmentally friendly and has high economic benefits; in addition, this "encapsulation technology" does not affect the foam richness and foam stability.

[0062] The present invention also adds a liquid crystal phase-induced structuring agent to the hair cosmetic composition, using the liquid crystal phase-induced structuring agent to provide good suspension ability and improve the stability of the product, adopting the "suspension technology"; among them, the "encapsulation technology" and the "suspension technology" are applied to the hair cosmetic composition at the same time. The "suspension technology" can synergistically enhance the effect with the "encapsulation technology", reduce the irritation of the hair cosmetic composition, improve the utilization rate of effective substances, and improve the anti-dandruff durability and foam stability of the hair cosmetic composition. Detailed Embodiments

[0063] To make the technical problems, technical solutions, and technical advantages to be solved by the present invention clearer, the following will be described in detail with specific examples. However, the protection scope of the present invention is not limited to the following specific embodiments. The described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and even less a limitation of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the protection scope of the present invention.

[0064] Unless otherwise defined, all professional terms used hereinafter have the same meaning as commonly understood by those skilled in the art. The professional terms used herein are only for the purpose of describing specific embodiments and are not intended to limit the protection scope of the present invention.

[0065] Unless otherwise specifically stated, various raw materials, reagents, instruments, and equipment used in the present invention can be obtained through market purchases or can be prepared by existing methods.

[0066] Examples 1 to 3 and Comparative Examples 1 to 3 respectively provide a hair cosmetic composition, and the amounts of raw materials in each hair cosmetic composition are shown in Table 1.

[0067] Table 1:

[0068]

[0069]

[0070] Specifically, the preparation method of the selenium disulfide inclusion complex in the examples includes the following steps:

[0071] S1. Mix cyclodextrin and deionized water evenly to obtain a cyclodextrin solution;

[0072] S2. Disperse selenium disulfide powder and a dispersant evenly to obtain a selenium disulfide suspension;

[0073] S3. Mix the cyclodextrin solution and the selenium disulfide suspension and grind them in a grinder for 0.5 to 1.5 h. The ground product gradually becomes viscous and pasty to obtain a mixed product;

[0074] S4. Dry the mixed product to obtain a selenium disulfide inclusion complex.

[0075] Specifically, the mass ratio of the cyclodextrin to the deionized water is 1:4.

[0076] Specifically, the mass ratio of the selenium disulfide powder to the dispersant is 1:4.

[0077] Specifically, the particle size of the selenium disulfide powder is 420 to 770 nm.

[0078] Specifically, the dispersant is glycerol.

[0079] Particularly, the selenium disulfide inclusion complex described in the present invention is formed by mixing a cyclodextrin solution and the selenium disulfide suspension, with a mixing ratio of 1:1. The selenium disulfide content in the finally obtained selenium disulfide inclusion complex is 40%.

[0080] The preparation method of the selenium disulfide inclusion complex of Comparative Example 2 can be obtained in the same way. The selenium disulfide in Comparative Example 1 and Comparative Example 3 is directly added to the hair care composition. The preparation methods of the hair care compositions provided in Examples 1 to 3 and Comparative Examples 1 to 3 are conventional preparation and mixing techniques, which will not be described in detail herein.

[0081] The following tests were conducted on the hair care compositions prepared in Examples 1 to 3 and Comparative Examples 1 to 3 above:

[0082] (I) Chicken embryo test:

[0083] (1) Test purpose and principle: Samples prepared from different components of the above experimental examples and comparative examples were taken for chicken embryo vascular reaction tests. The chicken embryo chorioallantoic membrane test (CAM) is a respiratory membrane that surrounds the chicken embryo. This test utilizes the characteristics of the vascular system of the chorioallantoic membrane in the middle stage of the hatched chicken embryo being complete, clear, and transparent. A certain amount of the test substance is directly contacted with the chorioallantoic membrane of the chicken embryo. After acting for a period of time, the changes in the toxicity effect indicators of the chorioallantoic membrane (such as bleeding, coagulation, and vascular lysis) are observed. These indicators reflect the changes in the morphological structure, color, and permeability of blood vessels and vascular networks, as well as the phenomena of protein denaturation of the chorioallantoic membrane and its degree of damage. Then, a score is combined to evaluate the eye irritation of the test substance;

[0084] (2) Test procedure: Six eggs were prepared for each group for hatching. For the chicken embryos on the 8th to 10th day of hatching, a hole was drilled above the air chamber with a hand drill, and part of the eggshell was peeled off with curved pointed forceps to expose the white egg membrane. 2 mL of 0.9% NaCl solution was added with a dropper to moisten the egg membrane, and then the 0.9% NaCl solution was poured out. Carefully tear off the inner membrane with forceps to ensure that the vascular membrane is not damaged. 0.3 mL of the test sample solution was added dropwise to the chicken embryo with a pipette. At this time, the test began. The CAM reaction was observed using a stereomicroscope, and the time when each toxicity effect appeared within 5 minutes was recorded. The specific test results are shown in Table 2 below.

[0085] Table 2:

[0086] Sample Score Average Score Irritation Classification Example 1 4.57 / 4.72 / 4.53 / 4.58 / 4.56 / 4.76 4.62 Mild Irritation Example 2 4.97 / 4.36 / 4.72 / 4.61 / 4.68 / 4.93 4.71 Mild Irritation Example 3 5.04 / 4.74 / 5.03 / 4.71 / 4.73 / 4.67 4.82 Mild Irritation Comparative Example 1 7.97 / 7.72 / 8.83 / 8.18 / 8.56 / 7.76 8.17 Moderate Irritation Comparative Example 2 6.51 / 6.42 / 6.63 / 6.68 / 6.72 / 6.86 6.64 Moderate Irritation Comparative Example 3 7.87 / 8.29 / 8.83 / 8.98 / 8.76 / 8.73 8.58 Moderate Irritation

[0087] As can be seen from Table 2 above, when selenium disulfide inclusions were not added in Comparative Example 1 and Comparative Example 3, their irritation was significantly stronger, indicating that adding selenium disulfide inclusions to the hair care composition of the present invention can significantly reduce the irritation of the product. By comparing Example 2, Comparative Example 2 and Comparative Example 3, it can be found that the irritation of the hair care compositions in Example 2 and Comparative Example 2 has been reduced, but the irritation of the hair care composition in Example 2 is significantly lower than that in Comparative Example 2. This shows that compared with the "encapsulation technology" used alone in Comparative Example 2, the "encapsulation technology" and "suspension technology" used simultaneously in Example 2 can synergistically enhance the effect and can assist in reducing irritation in the hair care composition.

[0088] (II) Anti-dandruff efficacy test:

[0089] The anti-dandruff efficacy test was carried out by taking photos of dandruff at the test points before and after using the sample under ultraviolet light with a magnification of a scalp physiotherapy instrument. Based on the improvement of dandruff, if there is a statistical difference (improvement) between the test sample before and after use or between the control group and the test group, it is considered to have an anti-dandruff effect.

[0090] 30 volunteers with dandruff problems or severe dandruff, aged 20 - 30 years old, were recruited. Qualified subjects were selected according to the inclusion criteria and exclusion criteria, and the "ASFS score" (adherent scalp flaking score) was used to evaluate the scalp in different areas, and those with a score ≥ 2 were selected. The test time points were before using the sample, 24 hours after using the sample, 72 hours after using the sample, and 1 week after using the sample; in the evaluation area of the subjects, four areas with relatively severe dandruff were selected, and these four areas were evaluated at each test time point. During the test, the subjects were required to follow the instructions of the experiment. They were not allowed to wash their hair one day before the test, and were not allowed to wash their hair for one week after using the sample. The dandruff situation of the subjects was observed at the test time points, and photos of the dandruff at the test points of the subjects were taken with an instrument for comparative analysis. The specific test results are shown in Table 3 below.

[0091] Table 3:

[0092]

[0093] As can be seen from Table 3 above, the anti-dandruff persistence of the examples is significantly better than that of the comparative examples, indicating that the "suspension technology" and "encapsulation technology" of the composition of the present invention synergistically enhance the effect and can improve the anti-dandruff persistence of the product; as the addition amount of selenium disulfide inclusions increases, the overall anti-dandruff effect of the hair care composition of the examples also increases; however, by comparing Example 2 and Example 3, it can be found that their anti-dandruff efficacy has reached a saturated state and the anti-dandruff effects are not much different. Considering the product cost, the component ratio of Example 2 is preferably selected.

[0094] (III) Stability test:

[0095] Samples of different components in Examples 1 to 3 and Comparative Examples 1 to 3 were subjected to stability tests. The tests were carried out under five conditions: daylight lamp illumination, -15°C, 25°C, 40°C, and 48°C for 12 weeks, and the observation periods were 1, 2, 4, 8, and 12 weeks respectively. The discoloration and suspension stability were observed, and the specific test results are shown in Table 4 below:

[0096] Table 4:

[0097]

[0098]

[0099] As can be seen from Table 4 above, the Examples were tested for 12 weeks under five conditions: daylight lamp illumination, -15°C, 25°C, 40°C, and 48°C. Their overall stability was much higher than that of the Comparative Examples. Except for slight discoloration under daylight lamp illumination and at high temperature of 48°C at the 12th week, there were basically no other instability phenomena; in Comparative Example 1, selenium disulfide without the encapsulation technology was used, and discoloration and precipitation of different degrees occurred. It can be seen that the "encapsulation technology" of selenium disulfide in the present invention not only greatly improved the discoloration problem of selenium disulfide, but also played a role in suspending selenium disulfide in the system, which can increase the stability of the product; in Comparative Example 2, selenium disulfide without the suspension technology was used, and precipitation of different degrees mainly occurred. It can be seen that the "suspension technology" of selenium disulfide in the present invention improved the problem of uneven suspension and easy sinking of selenium disulfide.

[0100] (4) Foam test:

[0101] Dynamic foam analyzer: It can scientifically analyze liquid foams. By accurately measuring the height of the foam, it can measure the foaming property of the liquid and the stability of the foam, and realize the determination of the liquid content and foam type (the size and distribution of the bubbles) in the foam. The samples of Example 2, Comparative Example 2, and Comparative Example 3 were subjected to foam tests using a dynamic foam analyzer. The specific test results are shown in Table 5 below.

[0102] Table 5:

[0103]

[0104] In the foam stability test, three groups of selenium disulfide samples with the same proportional content were compared, that is, Example 2, Comparative Example 2, and Comparative Example 3 were compared. As can be seen from Table 5 above, Example 2 applying the "encapsulation technology" does not affect its foam richness and foam stability. The "suspension technology" can synergistically enhance the effect with the "encapsulation technology" and can improve the foam stability in the product.

[0105] The "encapsulation technology" of the present invention uses cyclodextrin as a carrier to encapsulate selenium disulfide to form an "inclusion body". Cyclodextrin is a cyclic oligosaccharide, an α-1,4-linked cyclic oligosaccharide obtained from starch degraded by glucosyltransferase. Due to differences in the number of glucose units, cyclodextrins with various cavity sizes are available. Its special structure enables cyclodextrin to form structures with large and small ports, which look like a truncated cone. The large mouth end is composed of secondary hydroxyl groups at the 2,3 positions of cyclodextrin, and the small mouth end is composed of primary hydroxyl groups above the 6 position on the other side of cyclodextrin. This gives cyclodextrin a truncated conical structure, which is characterized by a hydrophobic inner cavity and a hydrophilic outer surface. Therefore, it can provide a hydrophobic binding site like an enzyme and encapsulate various appropriate guests, such as organic molecules, inorganic ions, and gas molecules. The property of its inner cavity being hydrophobic and the outer being hydrophilic enables it to form inclusion compounds and molecular assembly systems with many organic and inorganic molecules based on van der Waals forces, hydrophobic interactions, and the matching between host and guest molecules, thereby protecting the encapsulated compounds from photo- and oxidative degradation and providing host-guest inclusion compounds with controllable release characteristics through molecular encapsulation, improving water solubility and bioavailability. This technology uses the hydrophobic inner cavity of cyclodextrin to encapsulate selenium disulfide molecules of different particle sizes through van der Waals forces. Commonly used cyclodextrins mainly include α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, which are composed of six, seven, and eight glucose molecules respectively.

[0106] Cyclodextrin as a carrier for encapsulating selenium disulfide has the following characteristics: ① Encapsulating selenium disulfide with cyclodextrin can greatly reduce the problem of color change caused by oxidation, and the slow-release effect of the encapsulated selenium disulfide in cyclodextrin can improve bioavailability and the durability of product efficacy; ② Its hydrophobic core can serve as a storage device for selenium disulfide, with a high loading capacity and can assist in the suspension stability system; ③ There are a large number of hydrophilic groups on the surface of cyclodextrin, making it highly hydrophilic and able to reduce the irritation of selenium disulfide in cosmetics to skin and mucosal tissues; ④ Cyclodextrin has good biodegradability and has little impact on the environment, meeting the development concept of green cosmetics.

[0107] The "suspension technology" of the present invention uses a liquid crystal phase-induced structuring agent to provide good suspension ability. The liquid crystal phase-induced structuring agent contains a lamellar surfactant phase, a spherical granular bilayer surfactant phase, or a coexistence of both, and can provide good suspension ability for the "inclusion body" of selenium disulfide in the suspension system. Compared with traditional carbopol suspension, its suspension ability is not affected by electrolytes and can maintain good suspension ability within a wide pH range.

[0108] The liquid crystal phase-inducing structurant exhibits shear thinning and can also suspend water-insoluble or partially water-soluble components. In this case, the surfactant forms a liquid crystal phase with a closely packed three-dimensional structure, which exhibits anisotropy and the characteristics of a non-Newtonian fluid. It can suspend water-insoluble or partially water-soluble components. Below the critical micelle concentration (CMC), the surfactant exists in the form of single molecules or ions and adsorbs on the solution surface to form surface adsorption. The concentration of the bulk phase is lower than the surface concentration, reducing its free energy. When the concentration reaches the CMC, the concentration inside the solution increases, and the surfactant forms molecular aggregates. When the concentration of the surfactant solution reaches the CMC, the surfactant exists in the form of micelle-spherical particles. As the concentration increases, the micelles form cylinders. With further increase in concentration, the cylinders are closely packed to form a lamellar structure. The hydrophobic part of the surfactant is on the inner side of the bilayer, and the hydrophilic part is on the outer side. Or it forms spheres with a series of concentric multilayer structures, i.e., onion-like structures. Between the layers of each ring, the hydrophilic groups are connected to water. Under close packing of the surfactant, the composition has excellent suspension properties, and selenium disulfide forms an independent discontinuous phase in the continuous matrix composed of the surfactant composition.

[0109] The applicant has found through experiments that when dextrin-coated selenium disulfide and the liquid crystal phase-inducing structurant are simultaneously applied to a product, it can effectively reduce the irritation of the product and improve the foam stability of the product.

[0110] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solutions of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0111] In addition, it should be noted that, in the above specific embodiments, the various specific technical features described can be combined in any appropriate manner without contradiction. To avoid unnecessary repetition, the present invention will not separately describe various possible combination methods.

[0112] In addition, any combination can be made between various different embodiments of the present invention as long as it does not violate the idea of the present invention, and it should also be regarded as the content disclosed by the present invention.

Claims

1. A hair cosmetic composition containing selenium disulfide inclusions, characterized in that, Comprising the following raw materials by weight percentage: (A) Selenium disulfide inclusion 0.2% - 2.0%; (B) Anionic surfactant 8% - 20%; (C) Amphoteric surfactant 0.5% - 6%; (D) Nonionic surfactant 0.5% - 2%; (E) Liquid crystal phase - induced structuring agent 0.5% - 10%; (F) Cationic polysaccharide 0.2% - 0.8%; (G) Non - volatile conditioner 0.05% - 5%; And the balance of (H) pure water.

2. The hair cosmetic composition containing selenium disulfide inclusions according to claim 1, characterized in that, The selenium disulfide inclusion is obtained by dissolving cyclodextrin in deionized water to form a solution, mixing and dispersing selenium disulfide powder with a dispersant to form a suspension; then mixing the solution and the suspension and grinding in a grinder, and finally drying.

3. The hair care composition containing selenium disulfide inclusions according to claim 2, characterized in that, The dispersant is at least one of polyol, N - acyl amino acid surfactant solution, alkyl betaine surfactant solution, and sulfobetaine surfactant solution.

4. The hair cosmetic composition containing selenium disulfide inclusions according to claim 1, characterized in that, The structural formula of the anionic surfactant is as follows: RO(C2H4O) n SO3 - M + ; Wherein, R is an alkyl group of C8 - C18, n is the degree of ethoxylation, n is an integer greater than or equal to zero, and M is a monovalent cation.

5. The hair cosmetic composition containing selenium disulfide inclusions according to claim 1, characterized in that, The amphoteric surfactant includes at least one of cocamidopropyl betaine, cocamidopropyl hydroxysulfobetaine, sodium lauroamphoacetate, sodium cocoamphoacetate, sodium lauroamphodiacetate, and sodium cocoamphodiacetate.

6. The hair cosmetic composition containing selenium disulfide inclusions according to claim 1, characterized in that The nonionic surfactant includes coconut oil amide MEA and coconut oil amide methyl MEA. The content of coconut oil amide MEA is 1% - 2%, and the content of coconut oil amide methyl MEA is 0.5% - 1%.

7. The hair cosmetic composition containing selenium disulfide inclusions according to claim 1, characterized in that, The liquid crystal phase - induced structuring agent includes fatty alcohol and trihydroxystearin; the mass ratio of the fatty alcohol to the trihydroxystearin is 5 - 8:3 - 8.

8. The hair care composition containing selenium disulfide inclusions according to claim 1, characterized in that The cationic polysaccharide is a compound of guar gum hydroxypropyltrimethylammonium chloride and polyquaternium - 10 in a mass ratio of 3:

1.

9. The hair cosmetic composition containing selenium disulfide inclusions according to claim 1, wherein The non - volatile conditioner is one or two of emulsified polysiloxane and amino silicone oil.

10. The hair cosmetic composition containing selenium disulfide inclusions according to claim 1, characterized in that, The hair - care composition containing selenium disulfide inclusion further includes at least one of the following raw materials by weight percentage: humectant 0.1% - 5%; sunscreen 0.01% - 5%; preservative 0.01% - 1%; pH regulator 0.001% - 2%; essence 0.01% - 3%; viscosity regulator 0.01% - 4%.

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