Acne removal composition, preparation method and application of acne removal composition in cosmetics

Abstract

The invention relates to the technical field of cosmetics, and particularly discloses an acne-removing composition, a preparation method thereof and application of the acne-removing composition in cosmetics. The acne-removing composition is prepared from water, a humectant, salicylic acid, a radix sanguisorbae extract, a rheum palmatum extract, a honeysuckle flower extract, a radix salviae miltiorrhizae extract, 1, 2-hexanediol, a preservative, a thickening agent and a chelating agent. The acne removing composition can effectively remove acnes, the barrier function of skin is improved through the multi-dimensional synergistic effect, the skin side effect possibly caused by salicylic acid is remarkably reduced, and therefore the efficient and safe acne removing effect is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and particularly to an acne-removing composition, a preparation method thereof, and an application in cosmetics. Background Art

[0002] Acne, commonly known as "pimples", is a common chronic inflammatory skin disease that often occurs in areas rich in sebaceous glands such as the face. The typical manifestations of acne include comedones, papules, pustules, nodules, and cysts. The occurrence mechanism of acne involves multiple factors, such as excessive sebum secretion, blockage of the hair follicle sebaceous gland duct, bacterial infection (especially Propionibacterium acnes), and skin inflammatory reactions. These factors act together to cause the occurrence and development of acne, seriously affecting the appearance and mental health of patients. Therefore, acne removal has become one of the important research directions in skin care products.

[0003] Currently, there are various acne-removing products on the market, aiming to prevent or treat acne through different channels. Traditional treatment methods include the use of antibiotics, hormonal drugs, plant extracts, chemical components such as fruit acids or salicylic acids, and physical therapies such as laser treatment. Among them, salicylic acid, as a lipophilic organic acid, is widely used in acne-removing products because of its antibacterial properties against microorganisms, its ability to dissolve skin cutin, promote the shedding of the cutin layer, remove the too-thick cutin layer to dredge pores, and its anti-inflammatory properties. Compared with other commonly used acne-removing ingredients, salicylic acid can enter the hair follicle to exert its effects and is suitable for daily skin care, and can be used without the guidance of a doctor. However, despite the above advantages of salicylic acid, there are also some significant problems in its actual application.

[0004] In view of this, it is necessary to develop a new acne-removing composition formula containing salicylic acid, which can not only effectively inhibit Propionibacterium acnes, but also reduce the irritation of salicylic acid to the skin, and provide a more gentle and efficient acne-removing solution. Summary of the Invention

[0005] In order to develop an acne-removing composition that can not only effectively inhibit Propionibacterium acnes but also reduce the irritation of salicylic acid to the skin, the present application provides an acne-removing composition, a preparation method thereof, and an application in cosmetics. The acne-removing composition of the present application can not only effectively remove acne, but also enhance the skin barrier function through multi-dimensional synergistic effects, significantly reducing the skin side effects that may be caused by salicylic acid, thus achieving an efficient and safe acne-removing effect.

[0006] In the first aspect, an acne-removing composition provided by the present application adopts the following technical solution: An anti-acne composition, comprising raw materials in the following mass percentages: 6% - 12% humectant, 1.5% - 2% salicylic acid, 0.5% - 1% sanguisorba officinalis extract, 0.5% - 1% rheum palmatum extract, 0.5% - 1% honeysuckle flower extract, 0.5% - 1% salvia miltiorrhiza root extract, 0.3% - 0.5% 1,2 - hexanediol, 0.3% - 0.5% - 1% preservative, 0.2% - 0.3% thickener, 0.02% - 0.06% chelating agent, and the balance is water.

[0007] In the above technical solution, sanguisorba officinalis, as a traditional Chinese medicine, has good antioxidant capacity and anti-inflammatory properties. The sanguisorba officinalis extract is mainly derived from the roots of sanguisorba officinalis and contains rich polyphenolic compounds, which can effectively scavenge free radicals and protect cells from oxidative damage. In addition, the sanguisorba officinalis extract has a certain anti-inflammatory effect, which helps to reduce the inflammatory reaction caused by acne, thereby promoting the repair and regeneration of damaged skin tissue.

[0008] Rheum palmatum is a plant of the polygonaceae family, and its rhizome is rich in anthraquinone derivatives and other active substances, such as emodin, etc. These components endow rheum palmatum with the effects of clearing heat and detoxifying, and purging heat and promoting defecation. Adding the rheum palmatum extract to skin care products can help regulate sebum secretion, inhibit the growth of propionibacterium acnes, and at the same time, the rheum palmatum extract also has a slight keratolytic effect, which helps to prevent pore blockage and improve skin texture.

[0009] Honeysuckle flower is the dried flower bud or newly opened flower of the genus lonicera, and is widely used in traditional Chinese medicine for treating febrile diseases. The components such as chlorogenic acid and luteoloside contained in the honeysuckle flower extract have antibacterial, anti-inflammatory, antiviral and anti-allergic effects, which endow it with good soothing and anti-inflammatory effects, and the honeysuckle flower extract also has a certain sense of coolness, which well relieves the skin discomfort caused by salicylic acid.

[0010] Salvia miltiorrhiza is one of the commonly used traditional Chinese medicines for promoting blood circulation and removing blood stasis. The salvia miltiorrhiza root extract contains various active ingredients such as tanshinone and cryptotanshinone, which endow it with good antioxidant capacity. Using the salvia miltiorrhiza root extract in skin care products can promote skin blood circulation, help remove aging keratinocytes, and make the skin smoother and more delicate. At the same time, the salvia miltiorrhiza root extract can also enhance the skin barrier function, improve the resistance of the skin to external stimuli, and has an auxiliary effect on reducing the irritation caused by salicylic acid.

[0011] In this application, by compounding four natural plant extracts, namely sanguisorba officinalis extract, rheum palmatum extract, honeysuckle flower extract and salvia miltiorrhiza root extract, a complex interaction network is formed. The sanguisorba officinalis extract and rheum palmatum extract act together on the skin surface, strengthening the physical barrier of the skin and enhancing the skin's tolerance to salicylic acid. While honeysuckle flower and salvia miltiorrhiza further optimize the internal microenvironment of the skin, inhibit the release of inflammatory factors, and further enhance the skin's tolerance to salicylic acid. Thus, while ensuring the acne treatment effect, the irritation of salicylic acid to the skin is significantly reduced. At the same time, the compounding of sanguisorba officinalis extract, rheum palmatum extract, honeysuckle flower extract and salvia miltiorrhiza root extract also further strengthens the acne treatment effect of the acne treatment composition, and through the synergistic effects in aspects such as inhibiting the reproduction of pathogenic bacteria, regulating sebum secretion, dredging pores, reducing skin inflammation and promoting wound healing, a better acne treatment effect is achieved.

[0012] Preferably, the mass ratio of the sanguisorba officinalis extract, rheum palmatum extract, honeysuckle flower extract, and salvia miltiorrhiza root extract is 0.75:0.83:0.68:0.6.

[0013] In the above technical solution, this application further optimizes the mass ratio of the sanguisorba officinalis extract, rheum palmatum extract, honeysuckle flower extract, and salvia miltiorrhiza root extract to 0.75:0.83:0.68:0.6, ensuring the maximization of the synergistic effect of the sanguisorba officinalis extract, rheum palmatum extract, honeysuckle flower extract, and salvia miltiorrhiza root extract in the composition. It not only further improves the acne treatment effect, but also significantly reduces the possible side effects brought by salicylic acid, achieving the high efficiency and mildness of the acne treatment composition.

[0014] Preferably, the acne treatment composition further includes 0.5% - 1% scutellaria baicalensis root extract and 0.5% - 1% oldenlandia diffusa extract.

[0015] In the above technical solution, the Scutellaria baicalensis root extract is rich in active ingredients such as baicalin, and has good antibacterial, anti-inflammatory and antioxidant properties, which can effectively inhibit the growth of Propionibacterium acnes and reduce skin inflammatory reactions; the Hedyotis diffusa extract is famous for its effects of clearing heat and detoxifying, and antiviral, which can further purify the skin environment and enhance the skin's self-repair ability. In this application, by adding the Scutellaria baicalensis root extract and the Hedyotis diffusa extract to the acne treatment composition, the flavonoid components in the Scutellaria baicalensis root extract directly inhibit melanin synthesis, while the Hedyotis diffusa extract promotes skin repair and improves the local microenvironment. The combination of the two can not only effectively reduce inflammatory reactions and reduce the formation of new acne marks, but also accelerate the fading of existing acne marks, solving the problem of acne marks from multiple perspectives, thereby comprehensively improving the comprehensive effect of the acne treatment composition and enabling the skin to recover to a healthy state in a short time. In addition, the addition of the Scutellaria baicalensis root extract and the Hedyotis diffusa extract can further effectively balance skin oil secretion, reduce the problem of pore blockage caused by excessive oil, and further prevent the recurrence of acne.

[0016] Preferably, the mass ratio of the Scutellaria baicalensis root extract to the Hedyotis diffusa extract is 0.65:0.72.

[0017] In the above technical solution, in this application, by further optimizing the mass ratio of the Scutellaria baicalensis root extract to the Hedyotis diffusa extract to 0.65:0.72, it is ensured that the synergistic effect of the two in the acne treatment composition reaches the best, further enhancing the repair ability of the skin barrier, further effectively reducing the formation of acne marks and the recurrence of acne, and further fading existing acne marks, thereby further improving the overall health of the skin.

[0018] Preferably, the moisturizer is composed of propylene glycol and betaine, and in terms of the mass percentage of the acne treatment composition, it includes 5% - 10% propylene glycol and 1% - 2% betaine.

[0019] In the above technical solution, in this application, propylene glycol and betaine are used as the moisturizer of the acne treatment composition. Propylene glycol, as a commonly used moisturizer, has good hygroscopicity and moisturizing effect, and can effectively lock in skin moisture and prevent skin dryness. Betaine, with its natural source and mild characteristics, further enhances the moisturizing effect and gives the product a good skin feel. By compounding propylene glycol and betaine in this application, it is ensured that while the acne treatment composition effectively treats acne, it can provide long-lasting moisturizing and nourishment for the skin.

[0020] In the second aspect, a preparation method of an acne treatment composition provided by this application adopts the following technical solution: A preparation method of an acne treatment composition includes the following steps: Step 1: Mix water, moisturizer, preservative, thickener, and chelating agent and heat to 80 - 85 °C, and stir evenly; Step 2: Cool the material obtained in Step 1 to below 40°C, add the remaining raw materials, and after stirring evenly, obtain the anti-acne composition.

[0021] In the above technical solution, in the present application, by adopting the method of step-by-step mixing in the preparation method, it is ensured that the components of the anti-acne composition are uniform, have good stability, and can retain the activity of each active ingredient to the greatest extent, ensuring the anti-acne effect and mildness of the anti-acne composition.

[0022] In the third aspect, an application of an anti-acne composition provided by the present application in cosmetics adopts the following technical solution: An application of an anti-acne composition in cosmetics, adding the anti-acne composition to cosmetics.

[0023] Preferably, the cosmetics include but are not limited to anti-acne lotion, anti-acne emulsion, anti-acne essence, anti-acne cream, etc., anti-acne mask liquid, etc.

[0024] In the above technical solution, the anti-acne composition provided by the present application can be widely applied to a variety of cosmetics, such as anti-acne lotion, anti-acne emulsion, anti-acne essence, anti-acne cream, and anti-acne mask liquid. Adding the anti-acne composition of the present application to cosmetics can not only effectively solve the acne problem, but also improve the overall skin care effect of the cosmetics, enabling consumers to feel a significant improvement in skin condition during use.

[0025] In summary, the present application includes at least one of the following beneficial technical effects: 1. Through the compounding of four natural plant extracts, namely Sanguisorba officinalis extract, Rheum palmatum extract, Lonicera japonica flower extract, and Salvia miltiorrhiza root extract, the present application can form a complex interaction network on the skin, thereby while ensuring the anti-acne effect, significantly reducing the irritation of salicylic acid to the skin, and synergistically acting from aspects such as inhibiting the reproduction of pathogenic bacteria, regulating sebum secretion, dredging pores, reducing skin inflammation, and promoting wound healing, achieving a better anti-acne effect.

[0026] 2. By further adding Scutellaria baicalensis root extract and Hedyotis diffusa extract to the anti-acne composition, the combination of the two can not only effectively reduce the inflammatory response, reduce the formation of new acne marks, but also accelerate the fading of existing acne marks, solve the acne mark problem from multiple angles, thereby comprehensively improving the comprehensive effect of the anti-acne composition, enabling the skin to recover to a healthy state in a short time, and further preventing the recurrence of acne. Specific Embodiments

[0027] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0028] The purchase manufacturers of some raw materials in the specific embodiments are shown in Table 1.

[0029] Table 1: Example 1 An acne removing composition, comprising water, a humectant, salicylic acid, sanguisorba officinalis extract, rheum palmatum extract, lonicera japonica flower extract, salvia miltiorrhiza root extract, 1,2 - hexanediol, a preservative, a thickener, a chelating agent.

[0030] Among them, the humectant is composed of propylene glycol and betaine.

[0031] Among them, the preservative is p - hydroxyacetophenone.

[0032] Among them, the thickener is xanthan gum.

[0033] Among them, the chelating agent is disodium ethylenediaminetetraacetate.

[0034] Among them, the preparation method of the acne removing composition comprises the following steps: Step 1: Mix water, the humectant, the preservative, the thickener, and the chelating agent and heat to 85 °C, and stir evenly; Step 2: Cool the material obtained in Step 1 to below 40 °C, add the remaining raw materials, and stir evenly to obtain the acne removing composition.

[0035] Example 2 An acne removing composition, different from Example 1, comprising water, a humectant, salicylic acid, sanguisorba officinalis extract, rheum palmatum extract, lonicera japonica flower extract, salvia miltiorrhiza root extract, 1,2 - hexanediol, a preservative, a thickener, a chelating agent.

[0036] Example 3 An acne removing composition, different from Example 1, comprising water, a humectant, salicylic acid, sanguisorba officinalis extract, rheum palmatum extract, lonicera japonica flower extract, salvia miltiorrhiza root extract, 1,2 - hexanediol, a preservative, a thickener, a chelating agent.

[0037] Example 4 An acne removing composition, different from Example 3, with inconsistent dosages of each raw material.

[0038] Example 5 An acne removing composition, different from Example 3, with inconsistent dosages of each raw material.

[0039] The dosages of each raw material in Examples 1 - 5 are shown in Table 2.

[0040] Table 2: Example 6 An anti-acne composition, different from Example 3, further comprises Scutellaria baicalensis root extract and Hedyotis diffusa extract.

[0041] Example 7 An anti-acne composition, different from Example 3, further comprises Scutellaria baicalensis root extract and Hedyotis diffusa extract.

[0042] Example 8 An anti-acne composition, different from Example 3, further comprises Scutellaria baicalensis root extract and Hedyotis diffusa extract.

[0043] The dosage of each raw material in Examples 6 to 8 is shown in Table 3.

[0044] Table 3: Example 9 An anti-acne composition, different from Example 6, the Scutellaria baicalensis root extract is replaced with Coptis chinensis extract in equal amount.

[0045] Example 10 An anti-acne composition, different from Example 6, the Hedyotis diffusa extract is replaced with Houttuynia cordata extract in equal amount.

[0046] Comparative Example 1 An anti-acne composition, different from Example 3, the Sanguisorba officinalis extract is replaced with tea extract in equal amount.

[0047] Comparative Example 2 An anti-acne composition, different from Example 3, the Rheum palmatum extract is replaced with Phellodendron amurense extract in equal amount.

[0048] Comparative Example 3 An anti-acne composition, different from Example 3, the Lonicera japonica flower extract is replaced with Poria cocos extract in equal amount.

[0049] Comparative Example 4 An anti-acne composition, different from Example 3, the Salvia miltiorrhiza root extract is replaced with Spatholobus suberectus extract in equal amount.

[0050] Comparative Example 5 An anti-acne composition, different from Example 1, the Sanguisorba officinalis extract, Rheum palmatum extract, Lonicera japonica flower extract, and Salvia miltiorrhiza root extract are replaced with water in equal amount.

[0051] 1. Irritation test Referring to the skin irritation / corrosion test in the Cosmetics Safety and Technology Standard (2015 Edition), the irritation effects of the anti-acne compositions of Examples 1 to 10 and Comparative Examples 1 to 5 on the skin were evaluated.

[0052] Select several adult, healthy white rabbits without skin lesions as experimental animals. After adaptive feeding, they are evenly divided into 15 groups, with 4 rabbits in each group, half male and half female. About 3 cm * 3 cm of hair is removed from both sides of the spine 24 h before the experiment. Take 0.5 mL of the anti-acne composition and apply it correspondingly on the left skin of the white rabbits, then fix it with gauze, and the right skin is used as a control. After 4 h of application, wash it with warm water, dry the skin, and observe and record whether there are skin irritation reactions such as erythema and edema at the skin administration site at 1 h, 12 h, and 24 h. Refer to the scoring criteria in Table 4 for acute skin irritation evaluation, and the scoring results are the average scores of each animal in each group, as shown in Table 5.

[0053] Select several adult, healthy white rabbits without skin lesions as experimental animals. After adaptive feeding, they are evenly divided into 15 groups, with 4 rabbits in each group, half male and half female. About 3 cm * 3 cm of hair is removed from both sides of the spine 24 h before the experiment. Take 0.5 mL of the anti-acne composition and apply it correspondingly on the left skin of the white rabbits, then fix it with gauze, and the right skin is used as a control. Apply it once a day for 7 consecutive days. Starting from the second day of administration, remove the test residues with warm water every day. Observe and record whether there are skin irritation reactions such as erythema and edema at the skin administration site at 1 h, 12 h, and 24 h, and refer to the scoring criteria in Table 4 for multiple skin irritation evaluation. The scoring results are the average scores of each animal in each group every day, as shown in Table 5.

[0054] Table 4: Table 5: Specifically, in combination with Examples 1 to 10, Comparative Examples 1 to 5 and Table 5 for analysis, it can be seen that in the examples, no obvious irritation reactions occurred in the anti-acne compositions, which indicates that the anti-acne composition of the present application has no irritation to the skin and high safety. Thus, it can be seen that in the present application, the compounding of the four natural plant extracts of Sanguisorba officinalis extract, Rheum palmatum L. extract, Lonicera japonica Thunb. extract and Salvia miltiorrhiza Bunge root extract can significantly reduce the irritation of salicylic acid to the skin while ensuring the anti-acne effect.

[0055] 2. Anti-acne efficacy test Select 150 volunteers with strong facial oil secretion and at least 3 acne in the outbreak period on each side of the left and right cheeks. The age range is between 18 and 40 years old. They are evenly divided into 15 groups, with 10 people in each group, and evaluate the anti-acne efficacy of the anti-acne compositions of the above examples and comparative examples. The usage method is to apply it on the whole face after morning and evening cleansing and massage until completely absorbed.

[0056] During the experiment, the facial skin conditions of the volunteers were collected at baseline, on the 14th day, and on the 28th day respectively. The collected contents included the skin heme content (E value) and the change in facial acne volume (%). The collection instruments were the Mexameter MX18 skin melanin and heme test probe of CK Company in Germany and the skin rapid three-dimensional imaging system PRIMOS pico. The average value of the detection results of each group was taken, as shown in Table 6. Among them, the change rate of skin heme content (%) = [(baseline value - subsequent value) / baseline value] * 100%.

[0057] Table 6: Specifically, in combination with Examples 1-10, Comparative Examples 1-5, and Table 6 for analysis, it can be seen that in the examples, the acne-removing compositions significantly reduced the skin heme content on the faces of the volunteers and significantly reduced the acne volume. This indicates that the acne-removing compositions of the present application have a significant acne-removing effect, which shows that the compounding of the four natural plant extracts of Sanguisorba officinalis extract, Rheum palmatum extract, Lonicera japonica flower extract, and Salvia miltiorrhiza root extract can synergistically act in aspects such as inhibiting the reproduction of pathogenic bacteria, regulating sebum secretion, dredging pores, reducing skin inflammation, and promoting wound healing, achieving a better acne-removing effect.

[0058] 3. Evaluation of the effect of fading acne marks A total of 60 volunteers with a history of acne, currently having no acne on the face or an acne grade not higher than Grade II (Pillsbury four-grade modified classification method), and having residual erythema and / or pigmentation were selected. The age range was between 18 and 40 years old, and they were evenly divided into 6 groups with 10 people in each group. The effect of fading acne marks of the acne-removing compositions of Examples 3 and 6-10 was evaluated. The usage method was to apply it evenly on the whole face after cleansing in the morning and evening and massage until completely absorbed.

[0059] During the experiment, the facial skin conditions of the volunteers were collected at baseline, on the 14th day, and on the 28th day respectively to evaluate the fading situation of the acne marks of the volunteers. The evaluation criteria are shown in Table 7, and the average value of the evaluation results of each group is shown in Table 8.

[0060] Table 7: Table 8: Group Baseline Day 14 Day 28 Example 3 5.42 4.51 3.43 Example 6 5.63 3.92 2.29 Example 7 5.55 4.05 2.44 Example 8 5.57 3.97 2.36 Example 9 5.48 4.36 3.11 Example 10 5.61 4.39 3.09 Specifically, in combination with Examples 3 and 6-10 and Table 8 for analysis, it can be seen that in Examples 6-8, the acne-removing compositions significantly reduced the acne mark scores on the faces of the volunteers, indicating that the acne-removing compositions of Examples 6-8 have an obvious effect of fading acne marks, which shows that the acne-removing compositions containing Scutellaria baicalensis root extract and Hedyotis diffusa extract have a significant effect on fading acne marks.

[0061] This specific embodiment is only an interpretation of the present application and does not limit the present application. After reading this specification, those skilled in the art can make modifications to this embodiment that do not contribute creatively as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. An acne-removing composition, characterized in that, The raw materials include the following components by mass percentage: 6% - 12% humectant, 1.5% - 2% salicylic acid, 0.5% - 1% Sanguisorba officinalis extract, 0.5% - 1% Rheum palmatum L. extract, 0.5% - 1% Lonicera japonica Thunb. extract, 0.5% - 1% Salvia miltiorrhiza Bunge root extract, 0.3% - 0.5% 1,2 - hexanediol, 0.3% - 0.5% - 1% preservative, 0.2% - 0.3% thickener, 0.02% - 0.06% chelating agent, and the balance is water.

2. The anti-acne composition according to claim 1, wherein The mass ratio of the Sanguisorba officinalis extract, Rheum palmatum L. extract, Lonicera japonica Thunb. extract, and Salvia miltiorrhiza Bunge root extract is 0.75:0.83:0.68:0.

6.

3. The anti-acne composition according to claim 1, wherein The acne - removing composition further includes 0.5% - 1% Scutellaria baicalensis Georgi root extract and 0.5% - 1% Hedyotis diffusa Willd. extract.

4. A acne removing composition according to claim 3, characterized in that, The mass ratio of the Scutellaria baicalensis Georgi root extract and Hedyotis diffusa Willd. extract is 0.65:0.

72.

5. The acne-removing composition according to claim 1, characterized in that The humectant is composed of propylene glycol and betaine, and by mass percentage of the acne - removing composition, it includes 5% - 10% propylene glycol and 1% - 2% betaine.

6. A method for preparing an acne-removing composition according to any one of claims 1 to 5, characterized in that, It includes the following steps: Step 1: Mix water, humectant, preservative, thickener, and chelating agent and heat to 80 - 85 °C, and stir evenly. Step 2: Cool the material obtained in Step 1 to below 40 °C, add the remaining raw materials, and after stirring evenly, obtain the acne - removing composition.

7. Use of an acne-removing composition according to any one of claims 1 to 5 in cosmetics, characterized in that, Add the acne - removing composition into cosmetics.

8. Use of an anti-acne composition according to claim 7 in cosmetics, characterized in that, The cosmetics include, but are not limited to, acne - removing lotion, acne - removing emulsion, acne - removing essence, acne - removing cream, etc., acne - removing mask liquid, etc.

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