Traditional Chinese medicine preparation for preventing and treating venous thrombosis at PICC (Peripherally Inserted Central Catheter) and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine preparation for preventing and treating venous thrombosis at a PICC (Peripherally Inserted Central Catheter) and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following components in parts by weight: 25-35 parts of caulis spatholobi, 25-35 parts of radix astragali, 15-25 parts of radix cyathulae, 10-20 parts of herba artemisiae anomalae, 10-20 parts of vinegar-processed curcuma zedoary, 10-20 parts of cassia twig, 10-20 parts of lycopodium clavatum, 5-12 parts of fructus forsythiae, 5-12 parts of ground beeltle, 5-12 parts of fructus liquidambaris and 3-9 parts of liquorice. The traditional Chinese medicine preparation is prepared from antithrombotic and heat-clearing and detoxifying traditional Chinese medicines, is proper in compatibility of the components, clear in mechanism and synergistic in effect, and has better clinical application value. Clinical verifications prove that the traditional Chinese medicine preparation has no toxic or side effect and is not easy to generate adverse reaction.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site, its preparation method and application. Background Art

[0002] During chemotherapy for tumor patients, in order to avoid infection or vascular damage caused by repeated punctures, peripherally inserted central catheter (PICC) has become a commonly used infusion method. However, affected by factors such as psychology and venous thrombosis, it is prone to difficult catheter removal, leading to an increased risk of vascular damage and infection in patients, which not only affects the treatment effect but also aggravates the condition. Therefore, early prevention of common adverse reactions of PICC catheterization is required clinically to reduce patient pain, enhance the curative effect and patient compliance.

[0003] As an invasive operation, PICC catheterization can increase the risk of thrombosis, infection, etc. in patients to a certain extent. Venous thrombosis is a serious complication in PICC catheterization patients, which can affect the treatment of patients and even increase the mortality rate of patients. Some patients with malignant tumors die due to concurrent venous thrombosis. PICC catheterization infection is also a common adverse reaction. When it occurs, the patient has local pain, redness, swelling or purulent discharge at the catheterization site, which affects the quality of life and compliance of the patient. Its occurrence may be related to the history of underlying diseases, catheterization time, number of chemotherapy sessions and changes in the levels of related cytokines.

[0004] Most existing externally applied traditional Chinese medicine preparations use Sihuang powder water honey as the internal medicine, and its composition includes Phellodendron amurense, Coptis chinensis, Scutellaria baicalensis, etc., which can be applied to phlebitis, gout, joint pain, lower extremity venous thrombosis and other diseases. However, its effect of clearing heat and detoxifying, anti-inflammatory and preventing venous thrombosis is limited, the preparation process is cumbersome, and the quality standard is difficult to control. Sihuangshuimi may cause skin allergic reactions such as itching and rash, and it is not suitable for everyone. For example, patients allergic to Sihuang powder and adhesive tape, pregnant patients, those with damaged skin where application is required, and those with joint swelling and pain caused by deficiency syndrome and cold syndrome are not suitable to use Sihuangshuimi powder. Summary of the Invention

[0005] Aiming at the defects of the existing externally applied traditional Chinese medicine preparations in preventing venous thrombosis, the present invention provides a traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site, which has a positive therapeutic effect on venous thrombosis at the PICC catheterization site.

[0006] The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site of the present invention is made from the following components: 15-50 parts by weight of Caulis Spatholobi, 8-30 parts by weight of Astragalus membranaceus, 8-30 parts by weight of Cyathula officinalis Kuan, 8-30 parts by weight of Herba Artemisiae Anomalae, 8-30 parts by weight of Rhizoma Curcumae Aromaticae, 8-30 parts by weight of Ramulus Cinnamomi, 8-30 parts by weight of Herba Lycopodii, 5-18 parts by weight of Forsythia suspensa, 5-18 parts by weight of Eupolyphaga seu Steleophaga, 5-18 parts by weight of Clerodendrum cyrtophyllum Turcz., and 3-9 parts by weight of Glycyrrhiza uralensis Fisch..

[0007] In some embodiments of the present invention, the traditional Chinese medicine preparation is made from the following components: 25-35 parts by weight of Caulis Spatholobi, 25-35 parts by weight of Astragalus membranaceus, 15-25 parts by weight of Cyathula officinalis Kuan, 10-20 parts by weight of Herba Artemisiae Anomalae, 10-20 parts by weight of Rhizoma Curcumae Aromaticae, 10-20 parts by weight of Ramulus Cinnamomi, 10-20 parts by weight of Herba Lycopodii, 5-12 parts by weight of Forsythia suspensa, 5-12 parts by weight of Eupolyphaga seu Steleophaga, 5-12 parts by weight of Clerodendrum cyrtophyllum Turcz., and 3-9 parts by weight of Glycyrrhiza uralensis Fisch..

[0008] In one embodiment of the present invention, the traditional Chinese medicine preparation is made from the following components: 30 parts by weight of Caulis Spatholobi, 30 parts by weight of Astragalus membranaceus, 20 parts by weight of Cyathula officinalis Kuan, 15 parts by weight of Herba Artemisiae Anomalae, 15 parts by weight of Rhizoma Curcumae Aromaticae, 15 parts by weight of Ramulus Cinnamomi, 15 parts by weight of Herba Lycopodii, 9 parts by weight of Forsythia suspensa, 9 parts by weight of Eupolyphaga seu Steleophaga, 9 parts by weight of Clerodendrum cyrtophyllum Turcz., and 6 parts by weight of Glycyrrhiza uralensis Fisch..

[0009] In one embodiment of the present invention, the traditional Chinese medicine preparation is made from the following components: 30 parts by weight of Caulis Spatholobi, 25 parts by weight of Astragalus membranaceus, 20 parts by weight of Cyathula officinalis Kuan, 10 parts by weight of Herba Artemisiae Anomalae, 10 parts by weight of Rhizoma Curcumae Aromaticae, 20 parts by weight of Ramulus Cinnamomi, 20 parts by weight of Herba Lycopodii, 10 parts by weight of Forsythia suspensa, 10 parts by weight of Eupolyphaga seu Steleophaga, 9 parts by weight of Clerodendrum cyrtophyllum Turcz., and 6 parts by weight of Glycyrrhiza uralensis Fisch..

[0010] In one embodiment of the present invention, the venous thrombosis at the PICC catheterization site is the venous thrombosis at the PICC catheterization site of a patient with malignant tumor.

[0011] In one embodiment of the present invention, the venous thrombosis at the PICC catheterization site includes PICC-related upper extremity venous thrombosis.

[0012] In some embodiments of the present invention, the preparation is an external preparation.

[0013] In one embodiment of the present invention, the external preparation is a patch, an ointment, a cream, a gel, a paste, a spray, an aerosol, a microneedle preparation or a lotion.

[0014] In one embodiment of the present invention, the preparation method of the patch is: taking the original medicinal materials in the formula amount, grinding them into powder, adding an appropriate amount of water to make a paste, and placing it in a non-woven fabric medicine bag to obtain the patch.

[0015] The present invention also provides the use of the traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site in the preparation of drugs for venous thrombosis at the PICC catheterization site.

[0016] The properties and effects of each Chinese medicinal material in the present invention are as follows:

[0017] Caulis Spatholobi: Bitter and slightly sweet in taste, warm in nature, attributing to the liver and kidney meridians, promoting blood circulation and nourishing blood, regulating menstruation, and relaxing tendons and activating collaterals; used for irregular menstruation, dysmenorrhea, amenorrhea, rheumatic arthralgia, numbness of hands and feet, limb paralysis, and sallow complexion due to blood deficiency.

[0018] Astragalus membranaceus: Sweet in taste, slightly warm in nature, attributing to the lung and spleen meridians, tonifying qi and lifting yang, securing the exterior and stopping sweating, promoting diuresis and alleviating edema, generating body fluid and nourishing blood, promoting qi movement and dredging collaterals, expelling pus by supporting healthy qi, and promoting granulation for sore healing; used for qi deficiency with weakness, poor appetite and loose stools, qi sinking, chronic diarrhea with rectal prolapse, hematochezia, metrorrhagia and metrostaxis, spontaneous sweating due to exterior deficiency, qi deficiency edema, internal heat with thirst, sallow complexion due to blood deficiency, hemiplegia, arthralgia and numbness, carbuncle and ulcer difficult to rupture, and non-healing of chronic ulcer.

[0019] Cyathula officinalis Kuan: Sweet and slightly bitter in taste, neutral in nature, attributing to the liver and kidney meridians, expelling wind and removing dampness, dredging channels and activating blood circulation; used for treating rheumatic pain in the waist and knees, flaccidity of feet and tendons, bloody strangury, hematuria, amenorrhea in women, mass in the abdomen, retention of the placenta, arthralgia of joints, flaccidity of feet and tendons, bloody strangury and hematuria, and traumatic injury.

[0020] Artemisia anomala S. Moore: Bitter in taste, cold in nature, attributing to the spleen, stomach, liver and gallbladder meridians, promoting blood circulation to remove stasis, dredging channels and stopping pain, cooling blood and stopping bleeding, clearing heat and promoting diuresis, purging heat by bitter taste and clearing heat by cold nature, treating those with blood stasis and concurrent heat; used for traumatic injury, external bleeding, stasis obstruction of menstruation, irregular menstruation, postpartum stasis pain, mass accumulation, bloody dysentery, bloody strangury, damp-heat jaundice, edema and abdominal distension, and excessive leukorrhea.

[0021] Rhizoma Curcumae Aromaticae Vinegar Processed: Pungent and bitter in taste, warm in nature, attributing to the liver and spleen meridians, promoting qi movement and breaking blood stasis, promoting digestion and relieving pain; used for qi and blood pain, food retention and stagnation, abdominal distension and pain, blood stasis obstruction of menstruation, dysmenorrhea, mass and lump, and traumatic injury.

[0022] Ramulus Cinnamomi: Sweet in taste, slightly warm in nature, attributing to the lung and spleen meridians, tonifying qi and lifting yang, securing the exterior and stopping sweating, promoting diuresis and alleviating edema, generating body fluid and nourishing blood, promoting qi movement and dredging collaterals, expelling pus by supporting healthy qi, and promoting granulation for sore healing; used for qi deficiency with weakness, poor appetite and loose stools, qi sinking, chronic diarrhea with rectal prolapse, hematochezia, metrorrhagia and metrostaxis, spontaneous sweating due to exterior deficiency, and qi deficiency edema.

[0023] Herba Lycopodii: Slightly bitter and pungent in taste, warm in nature, attributing to the liver, spleen and kidney meridians, expelling wind and removing dampness, relaxing tendons and activating collaterals; used for wind-cold-damp arthralgia, pain due to contraction of tendons and vessels, and externally for traumatic sprain and swelling pain.

[0024] Fructus Forsythiae: Bitter in taste, cool in nature, attributing to the heart, liver and gallbladder meridians, clearing heat, detoxifying, dissipating binds, and detumescing; used for warm diseases, erysipelas, macula, carbuncle and sore, scrofula, and strangury with difficult urination.

[0025] Eupolyphaga seu Steleophaga: Salty in flavor, cold in nature, attributing to the Liver Meridian, promoting blood circulation to remove blood stasis, and reconnecting tendons and bones; used for traumatic injury, tendon injury and fracture, blood stasis amenorrhea, postpartum stasis abdominal pain, masses and nodules.

[0026] Liquidambar formosana Hance: Bitter in flavor, neutral in nature, attributing to the Liver and Kidney Meridians, expelling wind and activating collaterals, promoting diuresis, and dredging channels; used for arthralgia, numbness and contracture, edema and fullness, less lactation, and amenorrhea.

[0027] Glycyrrhiza uralensis Fisch.: Sweet in flavor, neutral in nature, attributing to the Heart, Lung, Spleen and Stomach Meridians, invigorating the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, alleviating spasm and pain, and coordinating the actions of various medicinal ingredients; used for weakness of the spleen and stomach, lassitude and fatigue, palpitation and shortness of breath, profuse phlegm and cough, abdominal and limb spasmodic pain, carbuncles and sores, and relieving toxicity and potency of drugs.

[0028] The traditional Chinese medicine preparation of the present invention selects traditional Chinese medicines for anti-thrombosis and clearing heat and detoxifying. Each component is properly combined, with clear mechanism and synergistic effect, and has good clinical application value. The dressing material and the traditional Chinese medicine are combined to prepare a traditional Chinese medicine dressing, which is wrapped in a non-woven bag for external use. The drug does not directly contact the skin, is not likely to cause skin damage at the catheterization site, the drug dose is controllable, and the drug delivery amount of each patch can be accurately controlled. It can be used immediately after being ground and mixed in clinical research, which can ensure the drug quality, so as to achieve the effect of preventing venous thrombosis at the PICC catheterization site in patients with malignant tumors.

[0029] Compared with the prior art, the present invention has the following advantages:

[0030] The traditional Chinese medicine preparation of the present invention can significantly shorten the time for the recovery of venous thrombosis after tumor PICC catheterization and the time for the subsidence of skin redness and swelling, effectively treat the formation of venous thrombosis after PICC catheterization in tumor patients, and provide a better product for clinically reducing and curing venous thrombosis after PICC catheterization.

[0031] Verified by clinical trials, this traditional Chinese medicine preparation has no toxic and side effects and is not likely to cause adverse reactions. Description of the Drawings

[0032] Figure 1 Comparison of the recovery time of each group. Different lowercase letters above the bar graph indicate significant differences between different groups (P < 0.05).

[0033] Figure 2 Comparison of the time for the subsidence of redness and swelling in each group. Different lowercase letters above the bar graph indicate significant differences between different groups (P < 0.05).

[0034] Figure 3 Comparison of the clinical efficacy of each group. Detailed Embodiments

[0035] To verify the efficacy of the traditional Chinese medicine preparation of the present invention, the inventor conducted a pharmacodynamic experiment study. It should be noted that the drugs selected for the pharmacodynamic experiment study of the present invention are the drugs obtained from the representative formula of the present invention and its preparation method. Due to space limitations, the experiments and results of the drugs obtained from other formulas and preparation methods included in the present invention are not listed one by one here.

[0036] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention pertains. Although the present invention only describes the preferred methods and materials, any methods and materials similar or equivalent to those described herein can also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to the said documents. In case of conflict with any incorporated document, the content of this specification shall prevail.

[0037] Example 1

[0038] Caulis Spatholobi 30g, Astragalus membranaceus 30g, Cyathula officinalis 20g, Herba Salviae Plebeiae 15g, Rhizoma Curcumae 15g (processed with vinegar), Ramulus Cinnamomi 15g, Lycopodium clavatum 15g, Forsythia suspensa 9g, Eupolyphaga seu Steleophaga 9g, Clerodendrum cyrtophyllum Turcz. 9g, Glycyrrhiza uralensis 6g.

[0039] The preparation method is as follows: Take the original medicinal materials in the formula amount, grind them into powder, add an appropriate amount of water to mix into a paste, and place it in a non-woven fabric medicine bag to obtain the patch.

[0040] Example 2

[0041] Caulis Spatholobi 30g, Astragalus membranaceus 25g, Cyathula officinalis 20g, Herba Salviae Plebeiae 10g, Rhizoma Curcumae 10g (processed with vinegar), Ramulus Cinnamomi 20g, Lycopodium clavatum 20g, Forsythia suspensa 10g, Eupolyphaga seu Steleophaga 10g, Clerodendrum cyrtophyllum Turcz. 9g, Glycyrrhiza uralensis 6g.

[0042] The preparation method is as follows: Take the original medicinal materials in the formula amount, grind them into powder, add an appropriate amount of water to mix into a paste, and place it in a non-woven fabric medicine bag to obtain the patch.

[0043] Example 3

[0044] Caulis Spatholobi 35g, Astragalus membranaceus 30g, Cyathula officinalis 15g, Herba Salviae Plebeiae 20g, Rhizoma Curcumae 15g (processed with vinegar), Ramulus Cinnamomi 10g, Lycopodium clavatum 20g, Forsythia suspensa 12g, Eupolyphaga seu Steleophaga 9g, Clerodendrum cyrtophyllum Turcz. 9g, Glycyrrhiza uralensis 9g.

[0045] The preparation method is as follows: Take the original medicinal materials in the formula amount, grind them into powder, add an appropriate amount of water to mix into a paste, and place it in a non-woven fabric medicine bag to obtain the patch.

[0046] Example 4

[0047] 35 g of Millettia reticulata Benth., 25 g of Astragalus membranaceus (Fisch.) Bunge, 25 g of Cyathula officinalis Kuan, 10 g of Artemisia anomala S. Moore, 20 g of Rhizoma Curcumae with vinegar, 10 g of Cinnamomum cassia Presl, 20 g of Lycopodium clavatum L., 5 g of Forsythia suspensa (Thunb.) Vahl, 12 g of Eupolyphaga sinensis Walker, 5 g of Liquidambar formosana Hance, 3 g of Glycyrrhiza uralensis Fisch.

[0048] The preparation method is as follows: Take the original medicinal materials in the formula amount, grind them into powder, add an appropriate amount of water to reconcile into a paste, and place it in a non-woven fabric medicine bag to obtain the patch.

[0049] Example 5

[0050] 25 g of Millettia reticulata Benth., 35 g of Astragalus membranaceus (Fisch.) Bunge, 15 g of Cyathula officinalis Kuan, 20 g of Artemisia anomala S. Moore, 10 g of Rhizoma Curcumae with vinegar, 20 g of Cinnamomum cassia Presl, 10 g of Lycopodium clavatum L., 12 g of Forsythia suspensa (Thunb.) Vahl, 5 g of Eupolyphaga sinensis Walker, 12 g of Liquidambar formosana Hance, 9 g of Glycyrrhiza uralensis Fisch.

[0051] The preparation method is as follows: Take the original medicinal materials in the formula amount, grind them into powder, add an appropriate amount of water to reconcile into a paste, and place it in a non-woven fabric medicine bag to obtain the patch.

[0052] Control Example 1

[0053] 30 g of Millettia reticulata Benth., 30 g of Astragalus membranaceus (Fisch.) Bunge, 25 g of Cyathula officinalis Kuan, 15 g of Rhizoma Curcumae with vinegar, 20 g of Cinnamomum cassia Presl, 20 g of Lycopodium clavatum L., 9 g of Forsythia suspensa (Thunb.) Vahl, 9 g of Eupolyphaga sinensis Walker, 9 g of Liquidambar formosana Hance, 6 g of Glycyrrhiza uralensis Fisch.

[0054] Compared with Example 1, the difference is that it does not contain Artemisia anomala S. Moore, and the dosages of Cyathula officinalis Kuan, Cinnamomum cassia Presl, and Lycopodium clavatum L. are increased.

[0055] The preparation method refers to Example 1.

[0056] Clinical Example Observation on the Efficacy of the Traditional Chinese Medicine Preparation of the Invention in Patients with Venous Thrombosis after PICC Catheterization

[0057] I. Data and Methods

[0058] 1. General Data

[0059] Ninety patients with venous thrombosis after PICC catheterization admitted to our hospital were selected as the research objects and randomly divided into a control group, a treatment group 1, and a treatment group 2, with 30 people in each group. Among them, the average age of the control group was (59.4 ± 8.6) years old; the average age of the treatment group 1 was (57.3 ± 7.1) years old; the average age of the treatment group 2 was (63.7 ± 10.2) years old.

[0060] Comparing the general data of each group of patients, there was no statistical difference (P > 0.05), and they were comparable.

[0061] 2. Inclusion Criteria

[0062] The patient was diagnosed with venous thrombosis after PICC catheterization; a tumor patient without other major diseases; the patient and his / her family were informed and consented to participate in this trial.

[0063] 3. Exclusion Criteria

[0064] Patients with indwelling catheters who are not tumor patients; patients with mental diseases; patients with severe systemic diseases; tumor patients who are pregnant or lactating.

[0065] 4. Treatment Methods

[0066] The patients in the control group were treated with low molecular heparin calcium injection, subcutaneously injected once a day for 7 days.

[0067] The patients in Treatment Group 1 applied the patch of Example 1, which was fixed with plastic wrap externally, applied to the catheterization site of PICC catheterized patients, and wet compress was performed locally twice a day in the morning and evening, 20 - 30 minutes each time.

[0068] The patients in Treatment Group 2 applied the patch of Comparative Example 1, which was fixed with plastic wrap externally, applied to the catheterization site of PICC catheterized patients, and wet compress was performed locally twice a day in the morning and evening, 20 - 30 minutes each time.

[0069] Each group was treated for 7 days.

[0070] 5. Observation Indicators

[0071] 5.1 Time for Clinical Symptoms to Disappear

[0072] During the treatment process and at the follow - up after treatment, record the time from the discovery to the cure and the time to cure of superficial thrombophlebitis.

[0073] 5.2 Treatment Effective Rate

[0074] Cure: The pain and swelling on the affected side completely disappear, and color Doppler ultrasound examination confirms that the diseased blood vessels are completely recanalized; Marked effect: The pain and swelling on the affected side basically disappear, and color Doppler ultrasound examination confirms that there is blood flow signal in the diseased blood vessels and mild reflux; Effective: The pain and swelling on the affected side are both reduced, and color Doppler ultrasound examination confirms that a small part of the diseased blood vessels is recanalized; Ineffective: The pain and swelling on the affected side are not reduced, and color Doppler ultrasound examination confirms no blood flow signal.

[0075] Total effective rate = (number of marked effect + effective) cases / total number of cases × 100%.

[0076] 6. Statistical Methods

[0077] SPSS 19.0 software was used for data processing, and the obtained data were expressed as For normal distribution test and homogeneity of variance test of each group of data, one - way analysis of variance was used for comparison between groups, and P < 0.05 was considered as having statistically significant difference.

[0078] II. Results

[0079] 1. Comparison of Time for Clinical Symptoms to Disappear in Each Group

[0080] Compared with the control group, there were differences in the time for the healing of superficial thrombophlebitis and the time for the subsidence of skin redness and swelling in the first treatment group on the 7th day after intervention between the groups.

[0081] Compared with the second treatment group, there were differences in the time for the healing of superficial thrombophlebitis and the time for the subsidence of skin redness and swelling in the first treatment group between the groups.

[0082] The results are shown in Figure 1 、 Figure 2 。

[0083] 2. Comparison of clinical efficacy of each group

[0084] Table 1 Comparison of clinical efficacy

[0085] Group Number of cases Total effective rate / % Control group 30 83.33 Treatment group 1 30 93.33 Treatment group 2 30 76.67

[0086] From Figure 3 and Table 1, it can be seen that the total effective rate of the control group was 83.33%, the total effective rate of the first treatment group was 93.33%, and the total effective rate of the second treatment group was 76.67%. The clinical efficacy of the first treatment group in improving patients with venous thrombosis after PICC catheterization was significantly better than that of the control group and the second treatment group.

[0087] The traditional Chinese medicine preparation of the present invention can significantly shorten the time for the healing of venous thrombosis after PICC catheterization for tumors and the time for the subsidence of skin redness and swelling, effectively treat the formation of venous thrombosis after PICC catheterization in tumor patients, and provide a better product for clinically alleviating and curing venous thrombosis after PICC catheterization.

[0088] The above embodiments do not impose any formal limitations on the present invention. For those skilled in the art, any modifications, substitutions, etc. made within the scope of the technical essence of the present invention and within the scope of the technical solution of the present invention still fall within the protection scope of the technical solution of the present invention.

Claims

1. A traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site, characterized in that, The traditional Chinese medicine preparation is made from the following components: 15 - 50 parts by weight of Caulis Spatholobi, 8 - 30 parts by weight of Radix Astragali, 8 - 30 parts by weight of Radix Cyathulae Officinalis, 8 - 30 parts by weight of Herba Artemisiae Anomalae, 8 - 30 parts by weight of Rhizoma Curcumae Aeruginosae processed with vinegar, 8 - 30 parts by weight of Ramulus Cinnamomi, 8 - 30 parts by weight of Herba Lycopodii, 5 - 18 parts by weight of Forsythia suspensa, 5 - 18 parts by weight of Eupolyphaga seu Steleophaga, 5 - 18 parts by weight of Fructus Liquidambaris, and 3 - 9 parts by weight of Glycyrrhiza uralensis Fisch..

2. The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to claim 1, wherein 25 - 35 parts by weight of Caulis Spatholobi, 25 - 35 parts by weight of Radix Astragali, 15 - 25 parts by weight of Radix Cyathulae Officinalis, 10 - 20 parts by weight of Herba Artemisiae Anomalae, 10 - 20 parts by weight of Rhizoma Curcumae Aeruginosae processed with vinegar, 10 - 20 parts by weight of Ramulus Cinnamomi, 10 - 20 parts by weight of Herba Lycopodii, 5 - 12 parts by weight of Forsythia suspensa, 5 - 12 parts by weight of Eupolyphaga seu Steleophaga, 5 - 12 parts by weight of Fructus Liquidambaris, and 3 - 9 parts by weight of Glycyrrhiza uralensis Fisch..

3. The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to claim 2, wherein The traditional Chinese medicine preparation is made from the following components: 30 parts by weight of Caulis Spatholobi, 30 parts by weight of Radix Astragali, 20 parts by weight of Radix Cyathulae Officinalis, 15 parts by weight of Herba Artemisiae Anomalae, 15 parts by weight of Rhizoma Curcumae Aeruginosae processed with vinegar, 15 parts by weight of Ramulus Cinnamomi, 15 parts by weight of Herba Lycopodii, 9 parts by weight of Forsythia suspensa, 9 parts by weight of Eupolyphaga seu Steleophaga, 9 parts by weight of Fructus Liquidambaris, and 6 parts by weight of Glycyrrhiza uralensis Fisch..

4. The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to claim 1, wherein The traditional Chinese medicine preparation is made from the following components: 30 parts by weight of Caulis Spatholobi, 25 parts by weight of Radix Astragali, 20 parts by weight of Radix Cyathulae Officinalis, 10 parts by weight of Herba Artemisiae Anomalae, 10 parts of Rhizoma Curcumae Aeruginosae processed with vinegar, 20 parts by weight of Ramulus Cinnamomi, 20 parts by weight of Herba Lycopodii, 10 parts by weight of Forsythia suspensa, 10 parts by weight of Eupolyphaga seu Steleophaga, 9 parts by weight of Fructus Liquidambaris, and 6 parts by weight of Glycyrrhiza uralensis Fisch..

5. The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to any one of claims 1-4, wherein, The venous thrombosis at the PICC catheterization site is the venous thrombosis at the PICC catheterization site of cancer patients.

6. The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to any one of claims 1 to 4, characterized in that The venous thrombosis at the PICC catheterization site includes PICC - related upper extremity venous thrombosis.

7. The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to any one of claims 1-4, characterized in that, The preparation is an external preparation.

8. The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to claim 7, wherein, The external preparation is a patch, an ointment, a cream, a gel, a paste, a spray, an aerosol, a microneedle preparation or a lotion.

9. The traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to claim 8, characterized in that, The preparation method of the patch is as follows: Take the original medicinal materials in the formula amount, grind them into powder, add an appropriate amount of water and mix them into a paste, and place them in a non - woven fabric medicine bag to obtain the patch.

10. Use of the traditional Chinese medicine preparation for preventing and treating venous thrombosis at the PICC catheterization site according to claim 1 in the preparation of drugs for preventing and treating venous thrombosis at the PICC catheterization site.

Images