An ultracentrifuge device for vaccine production with internal cleaning function

Abstract

The present invention discloses an ultracentrifuge device for vaccine production with an internal cleaning function, which relates to the technical field of centrifuge devices. An operator places a tube containing a vaccine on the rotor of a centrifugal rotating mechanism of a centrifugal chamber, a vacuum pump extracts the gas in the centrifugal chamber, and a motor drives the rotor at high speed to centrifuge the tube containing the vaccine. At the same time, the sample is cooled by a cooling mechanism to prevent denaturation or inactivation due to friction heat generated by high-speed centrifugation, thereby ensuring a stable separation environment. An adaptive cleaning mechanism that can shrink or pop out with the rotor speed cleans the inner wall of the centrifugal chamber at a low speed, thereby cleaning the inside of the centrifugal chamber, and the sewage generated by cleaning is discharged through a drainage mechanism, thereby preventing residual materials from contaminating subsequent vaccine production batches and ensuring vaccine quality.

Description

Technical Field

[0001] The invention relates to the technical field of centrifugal devices, in particular to an ultracentrifugal device for vaccine production with an internal cleaning function. Background Art

[0002] In the existing or traditional ultracentrifuge device, during the vaccine production process, after the vaccine is centrifuged, the rotor and chamber components are usually disassembled manually, and the inner wall of the centrifugal chamber is wiped and cleaned with a brush and detergent. Manual cleaning is often difficult to completely remove the residue on the inner wall of the centrifugal chamber, which may cause contamination to the subsequently produced vaccines.

[0003] Manual cleaning of the interior of an ultracentrifuge usually requires stopping the device, waiting for the ultracentrifuge to slow down and completely cool, and then manually disassembling the rotor and chamber components. This takes a long time, resulting in a long cleaning cycle, which seriously affects the efficiency of vaccine production. In addition, if the operator does not operate properly during manual disassembly and cleaning, liquid splashing may occur, which may lead to operator infection or contaminants remaining in the centrifuge chamber, resulting in contamination of subsequent vaccine production batches. Summary of the Invention

[0004] The object of the present invention is to provide an ultracentrifuge device for vaccine production with an internal cleaning function to solve the problems raised in the prior art.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] An ultracentrifuge device for vaccine production with an internal cleaning function, the centrifuge device includes a No. 1 shell, a centrifugal rotating mechanism, an adaptive cleaning mechanism, a cooling mechanism, a vacuum mechanism, a drainage mechanism and a centrifugal chamber, the No. 1 shell is fixedly connected to the centrifugal chamber, the centrifugal rotating mechanism is fixedly connected to the centrifugal chamber, the adaptive cleaning mechanism is fixedly connected to the centrifugal rotating mechanism, the cooling mechanism is fixedly connected to the centrifugal chamber, the vacuum mechanism is connected to the centrifugal chamber pipeline, and the drainage mechanism is fixedly connected to the centrifugal chamber.

[0007] By using the No. 1 shell as the installation basis for each mechanism, a stable working environment is provided for each mechanism. The operator places the tube containing the vaccine on the centrifugal rotating mechanism of the centrifugal chamber, extracts the gas in the centrifugal chamber through the vacuum mechanism, and rotates the centrifugal rotating mechanism at high speed to separate the vaccine sample in the tube containing the vaccine. At the same time, it is cooled by the cooling mechanism to prevent the sample from denaturing or inactivating due to friction heat generated by high-speed centrifugation, ensuring a stable separation environment. The centrifugal rotating mechanism runs at a low speed to enable the adaptive cleaning mechanism to clean the inner wall of the centrifugal chamber, thereby cleaning the inside of the centrifugal chamber, and the sewage generated by cleaning is discharged through the drainage mechanism, thereby preventing residual materials from contaminating subsequent vaccine production batches and ensuring vaccine quality.

[0008] Furthermore, the centrifugal rotating mechanism includes a motor, a rotating shaft, a base and a rotor, the motor is fixedly connected to the centrifugal chamber, the motor output end is fixedly connected to the rotating shaft, the rotating shaft is fixedly connected to the base, and the rotor is tightly connected to the base.

[0009] The motor is fixed outside the centrifugal chamber, and the motor output end and the rotating shaft are fixed, so that the motor drives the rotating shaft to rotate, the rotating shaft drives the base to rotate, and the base drives the rotor installed thereon to rotate, thereby centrifuging the tube containing the vaccine on the rotor.

[0010] Furthermore, the adaptive cleaning mechanism includes a centrifugal contraction unit, a connecting rod, a spray unit, a fixed rod, an adjusting mechanism, a scraper and a brush. The rotor is provided with a movable groove, the centrifugal contraction unit is placed in the movable groove, the connecting rod and the centrifugal contraction unit are fixedly connected, the spray unit and the connecting rod are fixedly connected, the fixed rod and the connecting rod are fixedly connected, the adjusting mechanism and the fixed rod are fixedly connected, the scraper and the adjusting mechanism are slidably connected, and the brush and the fixed rod are rotatably connected.

[0011] Through the centrifugal contraction unit, when the rotor rotates at high speed, the connecting rod and the components mounted thereon are contracted toward the movable groove of the rotor, so that the fixed rod and the spray unit are respectively embedded in the two reserved grooves of the rotor, thereby reducing air resistance during high-speed rotation and reducing motor energy consumption. At the same time, it avoids additional heat caused by exposed components, which affects sample activity. When the rotor rotates at low speed, the centrifugal contraction unit is reset, so that the connecting rod and the components mounted thereon are ejected, and the scraper and brush on the fixed rod are used to clean the inner wall of the centrifugal chamber. The cleaning liquid is sprayed by the spray unit to flush and moisten the sample residue on the inner wall of the centrifugal chamber, reducing the hardness and adhesion of the residue, making it easier for the scraper and brush to clean the residue on the inner wall of the centrifugal chamber. The contact pressure between the scraper and the inner wall of the centrifugal chamber is adjusted through the adjustment mechanism, and the scraping force of the scraper on stubborn residue is controlled to avoid excessive scraping force that may damage the cavity surface. The flow rate of the spray unit is also adjusted to achieve coordinated cleaning of scraping and rinsing, ensuring efficient removal of stubborn stains.

[0012] Furthermore, the centrifugal contraction unit includes an annular spring, a counterweight slider and a transmission rod. The rotor is provided with an annular groove, the annular spring is placed in the annular groove, the counterweight slider and the annular spring are fixedly connected, the transmission rod and the counterweight slider are movably connected, the transmission rod and the connecting rod are fixedly connected, the transmission rod and the rotor are hinged, and the counterweight slider and the annular groove are slidingly connected.

[0013] By arranging an annular spring and a counterweight slider in the annular groove of the rotor, when the rotor rotates at high speed, the counterweight slider overcomes the pulling force of the annular spring under the action of centrifugal force, the annular spring is stretched, and the counterweight slider slides along the annular groove, so that the counterweight slider pushes the transmission rod. The transmission rod first rotates slowly along the hinge and then rotates quickly to avoid damage to the cleaning components caused by excessive impact force during contraction. The torsion spring provided on the transmission rod hinge is compressed, thereby causing the transmission rod to retract to the movable groove. When the rotor rotates at low speed, the annular spring contracts, and the counterweight slider slides along the annular groove to reset. At the same time, the torsion spring releases the elastic force, causing the transmission rod to rotate along the hinge to reset.

[0014] Furthermore, the spray unit includes a water pump, a rotary joint, a cleaning liquid tank and a spray pipe. The water pump is connected to the rotary joint pipeline, the cleaning liquid tank is connected to the water pump pipeline, the spray pipe is connected to the rotary joint pipeline, and the spray pipe is fixedly connected to the connecting rod.

[0015] The cleaning liquid in the cleaning liquid tank is pumped into the rotary joint through the water pump through the pipeline. The rotary joint is connected to the pipeline inside the rotor and the spray pipe, so that the cleaning liquid flows into the spray pipe and is sprayed from the water outlet of the spray pipe. The water outlet of the spray pipe is directed towards the scraper, thereby flushing the inner wall of the centrifugal chamber and reducing the hardness and adhesion of the residue.

[0016] Furthermore, the adjustment mechanism includes a No. 1 spring, a guide rod, piezoelectric ceramics and an electrode. The No. 1 spring is sleeved outside the guide rod, the guide rod and the fixed rod are fixedly connected, the guide rod and the scraper are slidingly connected, the piezoelectric ceramics and the fixed rod are fixedly connected, the No. 1 spring and the piezoelectric ceramics are abutted, and the electrode and the piezoelectric ceramics are fixedly connected.

[0017] By installing the scraper on the guide rod, the scraper can slide along the guide rod. However, when encountering pollutants with different viscosities, the scraper can overcome the elastic force of the No. 1 spring and slide along the guide rod, so that the scraper fits more closely to the inner wall of the centrifugal chamber, increasing the contact area with the pollutants, thereby increasing the scraping force on the pollutants. Piezoelectric ceramics are installed at the bottom of the No. 1 spring in the compression direction. When the No. 1 spring is compressed, the pressure of the piezoelectric ceramics changes, causing it to produce a piezoelectric effect and generate current. The current passes through the electrodes fixed by the piezoelectric ceramics, and the electrodes are connected to the control system of the centrifugal device through electrical signals, so that the control system controls the water pump according to the current generated by the piezoelectric ceramics, thereby controlling the flow of the cleaning liquid.

[0018] Furthermore, spring No. 1 includes a variable pitch spiral section and a variable diameter spiral section, the variable pitch spiral section is fixedly connected to the scraper, the variable pitch spiral section is fixedly connected to the variable diameter spiral section, and the variable diameter spiral section is fixedly connected to the fixed rod.

[0019] The No. 1 spring is provided with two sections, a variable pitch spiral section and a variable diameter spiral section. When rotating at a low speed for cleaning, the variable pitch spiral section and the scraper are fixed, so that the scraper can adapt to materials of different viscosities. When cleaning high-viscosity pollutants, it provides a greater contact force, and when cleaning low-viscosity pollutants, it provides a smaller contact force, thereby avoiding incomplete cleaning or excessive wear of the inner wall of the centrifugal chamber. The variable diameter spiral section provides a greater elastic supporting force, which limits the displacement of the scraper during high-speed rotation and avoids damage to the adjustment structure caused by excessive centrifugal force.

[0020] Furthermore, the drainage mechanism includes a drainage pipe, an electromagnetic coil, a return spring and a slide. The drainage pipe is fixedly connected to the centrifugal chamber, the drainage pipe is provided with a liquid channel, the electromagnetic coil is fixedly connected to the liquid channel, the return spring is fixedly connected to the liquid channel, the slide is slidably connected to the liquid channel, and the slide is fixedly connected to the return spring.

[0021] By installing an electromagnetic coil in the drain pipe, the electromagnetic coil channel generates magnetic force. The slide is made of metal, so that the slide overcomes the elastic force of the return spring. The slide slides along the liquid channel toward the electromagnetic coil, connecting the drain pipe and the external pipeline, thereby draining the centrifugal chamber. When the centrifugal device is working, the electromagnetic coil is de-energized, and the return spring releases the elastic force, causing the slide to slide upward, thereby closing the drain pipe and preventing air leakage.

[0022] Furthermore, the vacuum mechanism includes a vacuum pump, a No. 2 shell, a No. 2 spring and a sealing cover. The vacuum pump is connected to the centrifugal chamber pipeline, the No. 2 shell is connected to the vacuum pump pipeline, the No. 2 spring is fixedly connected to the No. 2 shell, the sealing cover is fixedly connected to the No. 2 spring, and the sealing cover is abutted against the No. 2 shell.

[0023] The vacuum pump is connected to the internal pipeline of the centrifugal chamber so that the vacuum pump can extract the gas inside the centrifugal chamber. The gas output end of the vacuum pump is connected to the internal pipeline of the No. 2 shell so that the gas can be discharged through the No. 2 shell. A No. 2 spring and a sealing cover are set at the outlet of the No. 2 shell. When the gas needs to be discharged, the No. 2 spring is stretched and the sealing cover slides upward, thereby connecting the No. 2 shell with the outside world. When the vacuum pump stops running, the No. 2 spring pulls the sealing cover to seal the outlet of the No. 2 shell to prevent air leakage.

[0024] Furthermore, the cooling mechanism includes a cooling module, an air outlet pipe and an air return pipe. The cooling module is fixedly connected to the No. 1 shell, the air outlet pipe is fixedly connected to the cooling module, the air return pipe is fixedly connected to the cooling module, the air outlet pipe is connected to the centrifugal chamber, and the air return pipe is connected to the centrifugal chamber.

[0025] A small amount of cooling gas is input into the centrifugal chamber through the air outlet pipe through the cooling module, thereby cooling the inside of the centrifugal chamber to prevent the heat generated by the rotor when rotating at high speed, which may cause denaturation or inactivation of the vaccine sample. The gas inside the centrifugal chamber is extracted through the return air pipe, cooled in the cooling module, and then input into the centrifugal chamber through the air outlet pipe again, thereby continuously cooling the centrifugal chamber.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] 1. Through the adaptive cleaning mechanism integrated in the rotor, the inner wall of the centrifugal chamber can be cleaned after a single centrifugation, without stopping the ultracentrifuge to wait for the ultracentrifuge to slow down and completely cool down, thereby reducing the time required for cleaning, improving production efficiency, and avoiding contamination of subsequent vaccines caused by improper manual operation.

[0028] 2. Through the centrifugal contraction unit, the cleaning components are contracted into the rotor or the reserved slot when the rotor rotates at high speed, reducing the air resistance during high-speed rotation and the energy consumption of the motor. At the same time, it avoids the extra heat caused by the exposed components, which affects the activity of the sample.

[0029] 3. The adjustment unit enables the scraper to automatically adjust the scraping force according to the different viscosities of the pollutants, thereby reducing the scraper's wear on the inside of the centrifugal chamber and increasing the service life of the equipment. The piezoelectric ceramics generate different currents according to the changes in the elastic force of the spring, allowing the control system to accurately control the flow of the cleaning fluid and reduce the waste of the cleaning fluid.

[0030] 4. The temperature of the vaccine during centrifugation is controlled by combining the vacuum mechanism with the cooling mechanism to avoid denaturation or inactivation of the vaccine caused by frictional heat generated by high-speed centrifugation. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0032] Figure 2 It is a structural schematic diagram of the centrifugal rotating mechanism of the present invention;

[0033] Figure 3 Schematic diagram of the structure of the spray unit of the present invention;

[0034] Figure 4 Schematic diagram of the structure of the rotor of the present invention;

[0035] Figure 5 Schematic diagram of the structure of the centrifugal shrinkage unit of the present invention;

[0036] Figure 6 yes Figure 5 A magnified view of a part A;

[0037] Figure 7Schematic diagram of the structure of the annular spring of the present invention;

[0038] Figure 8 Schematic diagram of the connection of the piezoelectric ceramic of the present invention;

[0039] Figure 9 This is a schematic structural diagram of the No. 1 spring of the present invention;

[0040] Figure 10 It is a structural schematic diagram of the drainage mechanism of the present invention;

[0041] Figure 11 This is a schematic structural diagram of the second housing of the present invention;

[0042] Figure 12 It is a structural schematic diagram of the cooling mechanism of the present invention.

[0043] In the figure: 1. No. 1 shell; 2. Centrifugal rotating mechanism; 21. Motor; 22. Rotating shaft; 23. Base; 24. Rotor; 241. Movable groove; 242. Annular groove; 3. Adaptive cleaning mechanism; 31. Centrifugal contraction unit; 311. Annular spring; 312. Counterweight slider; 313. Transmission rod; 32. Connecting rod; 33. Spray unit; 331. Water pump; 332. Rotating joint; 333. Cleaning liquid tank; 334. Spray pipe; 34. Fixed rod; 35. Adjustment mechanism; 351. No. 1 bomb Spring; 3511, variable pitch spiral section; 3512, variable diameter spiral section; 352, guide rod; 353, piezoelectric ceramic; 354, electrode; 36, scraper; 37, brush; 4, cooling mechanism; 41, cooling module; 42, air outlet pipe; 43, air return pipe; 5, vacuum mechanism; 51, vacuum pump; 52, No. 2 shell; 53, No. 2 spring; 54, sealing cover; 6, drainage mechanism; 61, drainage pipe; 611, liquid channel; 62, electromagnetic coil; 63, reset spring; 64, slide; 7, centrifugal chamber. DETAILED DESCRIPTION

[0044] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative work shall fall within the scope of protection of the present invention.

[0045] Example: Figure 1-Figure 3As shown, the present invention provides a technical solution for an ultracentrifuge device for vaccine production with an internal cleaning function, an ultracentrifuge device for vaccine production with an internal cleaning function, the centrifuge device includes a No. 1 shell 1, a centrifugal rotating mechanism 2, an adaptive cleaning mechanism 3, a cooling mechanism 4, a vacuum mechanism 5, a drainage mechanism 6 and a centrifugal chamber 7, the No. 1 shell 1 and the centrifugal chamber 7 are fixedly connected, the centrifugal rotating mechanism 2 and the centrifugal chamber 7 are fixedly connected, the adaptive cleaning mechanism 3 and the centrifugal rotating mechanism 2 are fixedly connected, the cooling mechanism 4 and the centrifugal chamber 7 are fixedly connected, the vacuum mechanism 5 and the centrifugal chamber 7 are connected by a pipe, and the drainage mechanism 6 and the centrifugal chamber 7 are fixedly connected.

[0046] By using the No. 1 shell 1 as the installation basis for each mechanism, a stable working environment is provided for each mechanism. The operator places the tube containing the vaccine on the centrifugal rotating mechanism 2 of the centrifugal chamber 7, extracts the gas in the centrifugal chamber 7 through the vacuum mechanism 5, and rotates the centrifugal rotating mechanism 2 at high speed to separate the vaccine sample in the tube containing the vaccine. At the same time, it is cooled by the cooling mechanism 4 to prevent the sample from denaturing or inactivating due to friction heat generated by high-speed centrifugation, ensuring a stable separation environment. The centrifugal rotating mechanism 2 is operated at a low speed to enable the adaptive cleaning mechanism 3 to clean the inner wall of the centrifugal chamber 7, thereby cleaning the inside of the centrifugal chamber 7, and the sewage generated by cleaning is discharged through the drainage mechanism 6, thereby preventing residual materials from contaminating subsequent vaccine production batches and ensuring vaccine quality.

[0047] like Figure 2 As shown, the centrifugal rotating mechanism 2 includes a motor 21, a rotating shaft 22, a base 23 and a rotor 24. The motor 21 is fixedly connected to the centrifugal chamber 7, the output end of the motor 21 is fixedly connected to the rotating shaft 22, the rotating shaft 22 is fixedly connected to the base 23, and the rotor 24 is tightly connected to the base 23.

[0048] The motor 21 is fixed to the outside of the centrifugal chamber 7, and the output end of the motor 21 is fixed to the rotating shaft 22, so that the motor 21 drives the rotating shaft 22 to rotate, and the rotating shaft 22 drives the base 23 to rotate, and the base 23 drives the rotor 24 mounted thereon to rotate, thereby centrifuging the tube containing the vaccine on the rotor 24.

[0049] like Figure 4-Figure 6 As shown, the adaptive cleaning mechanism 3 includes a centrifugal contraction unit 31, a connecting rod 32, a spray unit 33, a fixed rod 34, an adjusting mechanism 35, a scraper 36 and a brush 37. The rotor 24 is provided with a movable groove 241. The centrifugal contraction unit 31 is placed in the movable groove 241. The connecting rod 32 is fixedly connected to the centrifugal contraction unit 31, the spray unit 33 is fixedly connected to the connecting rod 32, the fixed rod 34 is fixedly connected to the connecting rod 32, the adjusting mechanism 35 is fixedly connected to the fixed rod 34, the scraper 36 is slidably connected to the adjusting mechanism 35, and the brush 37 is rotatably connected to the fixed rod 34.

[0050] Through the centrifugal contraction unit 31, when the rotor 24 rotates at high speed, the connecting rod 32 and the components mounted thereon are contracted toward the movable groove 241 of the rotor 24, so that the fixed rod 34 and the spray unit 33 are respectively embedded in the two reserved grooves of the rotor 24, thereby reducing the air resistance during high-speed rotation and reducing the energy consumption of the motor 21. At the same time, it avoids the additional heat caused by the exposure of the components, which affects the activity of the sample. When the rotor 24 rotates at a low speed, the centrifugal contraction unit 31 is reset, so that the connecting rod 32 and the components mounted thereon are ejected, and the scraper 36 and the brush 37 on the fixed rod 34 are used to clean the sample. The inner wall of the centrifugal chamber 7 is cleaned, and the cleaning liquid is sprayed through the spray unit 33 to flush and moisten the sample residue on the inner wall of the centrifugal chamber 7, reducing the hardness and adhesion of the residue, making it easier for the scraper 36 and the brush 37 to clean the residue on the inner wall of the centrifugal chamber 7. The contact pressure between the scraper 36 and the inner wall of the centrifugal chamber 7 is adjusted through the adjustment mechanism 35, and the scraping force of the scraper 36 on the stubborn residue is controlled to avoid excessive scraping force that may damage the cavity surface, and the flow rate of the spray unit 33 is adjusted to achieve coordinated cleaning of scraping and rinsing, ensuring efficient removal of stubborn stains.

[0051] like Figure 5 and Figure 7 As shown, the centrifugal contraction unit 31 includes an annular spring 311, a counterweight slider 312 and a transmission rod 313. The rotor 24 is provided with an annular groove 242. The annular spring 311 is placed in the annular groove 242. The counterweight slider 312 and the annular spring 311 are fixedly connected. The transmission rod 313 and the counterweight slider 312 are movably connected. The transmission rod 313 and the connecting rod 32 are fixedly connected. The transmission rod 313 and the rotor 24 are hingedly connected. The counterweight slider 312 and the annular groove 242 are slidably connected.

[0052] By arranging an annular spring 311 and a counterweight slider 312 in the annular groove 242 of the rotor 24, when the rotor 24 rotates at a high speed, the counterweight slider 312 overcomes the pulling force of the annular spring 311 under the action of centrifugal force, the annular spring 311 is stretched, and the counterweight slider 312 slides along the annular groove 242, so that the counterweight slider 312 pushes the transmission rod 313, and the transmission rod 313 first rotates slowly along the hinge and then rotates quickly to avoid damage to the cleaning components caused by excessive impact force during contraction. The torsion spring provided on the hinge of the transmission rod 313 is compressed, thereby causing the transmission rod 313 to retract to the movable groove 241. When the rotor 24 rotates at a low speed, the annular spring 311 contracts, and the counterweight slider 312 slides and resets along the annular groove 242. At the same time, the torsion spring releases the elastic force, causing the transmission rod 313 to rotate along the hinge to reset.

[0053] like Figure 2-Figure 4As shown, the spray unit 33 includes a water pump 331, a rotary joint 332, a cleaning liquid tank 333 and a spray pipe 334. The water pump 331 and the rotary joint 332 are connected by a pipeline, the cleaning liquid tank 333 and the water pump 331 are connected by a pipeline, the spray pipe 334 and the rotary joint 332 are connected by a pipeline, and the spray pipe 334 and the connecting rod 32 are fixedly connected.

[0054] The cleaning liquid in the cleaning liquid tank 333 is pumped into the rotary joint 332 through the water pump 331 through the pipeline. The rotary joint 332 is connected to the pipeline inside the rotor 24 and the spray pipe 334, so that the cleaning liquid flows into the spray pipe 334 and is sprayed out from the water outlet of the spray pipe 334. The water outlet of the spray pipe 334 is directed toward the scraper 36, thereby flushing the inner wall of the centrifugal chamber 7 and reducing the hardness and adhesion of the residue.

[0055] like Figure 6 and Figure 8 As shown, the adjustment mechanism 35 includes a No. 1 spring 351, a guide rod 352, a piezoelectric ceramic 353 and an electrode 354. The No. 1 spring 351 is sleeved on the outside of the guide rod 352, the guide rod 352 and the fixed rod 34 are fixedly connected, the guide rod 352 and the scraper 36 are slidably connected, the piezoelectric ceramic 353 and the fixed rod 34 are fixedly connected, the No. 1 spring 351 and the piezoelectric ceramic 353 are abutted, and the electrode 354 and the piezoelectric ceramic 353 are fixedly connected.

[0056] By installing the scraper 36 on the guide rod 352, the scraper 36 can slide along the guide rod 352. However, when encountering pollutants of different viscosities, the scraper 36 can overcome the elastic force of the No. 1 spring 351 and slide along the guide rod 352, so that the scraper 36 is more closely attached to the inner wall of the centrifugal chamber 7, increasing the contact area with the pollutants, thereby increasing the scraping force on the pollutants. A piezoelectric ceramic 353 is installed at the bottom of the compression direction of the No. 1 spring 351. When the No. 1 spring 351 is compressed, the pressure of the piezoelectric ceramic 353 changes, causing it to produce a piezoelectric effect and generate current. The current passes through the electrode 354 fixed to the piezoelectric ceramic 353, and the electrode 354 is connected to the control system of the centrifugal device through an electrical signal, so that the control system controls the water pump 331 according to the current generated by the piezoelectric ceramic 353, thereby controlling the flow of the cleaning liquid.

[0057] like Figure 9 As shown, the No. 1 spring 351 includes a variable pitch spiral section 3511 and a variable diameter spiral section 3512, the variable pitch spiral section 3511 is fixedly connected to the scraper 36, the variable pitch spiral section 3511 is fixedly connected to the variable diameter spiral section 3512, and the variable diameter spiral section 3512 is fixedly connected to the fixed rod 34.

[0058] A variable pitch spiral section 3511 and a variable diameter spiral section 3512 are provided through the No. 1 spring 351. When rotating at a low speed for cleaning, the variable pitch spiral section 3511 and the scraper 36 are fixed, so that the scraper 36 can adapt to materials of different viscosities. When cleaning high-viscosity pollutants, a greater contact force is provided, and when cleaning low-viscosity pollutants, a smaller contact force is provided, thereby avoiding incomplete cleaning or excessive wear of the inner wall of the centrifugal chamber 7. The variable diameter spiral section 3512 provides a greater elastic supporting force, thereby limiting the displacement of the scraper 36 during high-speed rotation, thereby avoiding damage to the adjustment structure caused by excessive centrifugal force.

[0059] like Figure 10 As shown, the drainage mechanism 6 includes a drainage pipe 61, an electromagnetic coil 62, a return spring 63 and a slide 64. The drainage pipe 61 is fixedly connected to the centrifugal chamber 7. The drainage pipe 61 is provided with a liquid channel 611. The electromagnetic coil 62 is fixedly connected to the liquid channel 611. The return spring 63 is fixedly connected to the liquid channel 611. The slide 64 is slidably connected to the liquid channel 611. The slide 64 is fixedly connected to the return spring 63.

[0060] By installing an electromagnetic coil 62 in the drain pipe 61, the electromagnetic coil 62 channel generates magnetic force, and the slide 64 is made of metal, so that the slide 64 overcomes the elastic force of the return spring 63. The slide 64 slides along the liquid channel 611 toward the electromagnetic coil 62, so that the drain pipe 61 and the external pipeline are connected, thereby draining the centrifugal chamber 7. When the centrifugal device is working, the electromagnetic coil 62 is de-energized, and the return spring 63 releases the elastic force, causing the slide 64 to slide upward, thereby closing the drain pipe 61 and preventing air leakage.

[0061] like Figure 2 and Figure 11 As shown, the vacuum mechanism 5 includes a vacuum pump 51, a No. 2 shell 52, a No. 2 spring 53 and a sealing cover 54. The vacuum pump 51 is connected to the centrifugal chamber 7 by a pipeline, the No. 2 shell 52 is connected to the vacuum pump 51 by a pipeline, the No. 2 spring 53 is fixedly connected to the No. 2 shell 52, the sealing cover 54 is fixedly connected to the No. 2 spring 53, and the sealing cover 54 is abutted against the No. 2 shell 52.

[0062] The vacuum pump 51 is connected to the internal pipeline of the centrifugal chamber 7, so that the vacuum pump 51 can extract the gas inside the centrifugal chamber 7. The gas output end of the vacuum pump 51 is connected to the internal pipeline of the No. 2 shell 52, so that the gas is discharged through the No. 2 shell 52. By arranging a No. 2 spring 53 and a sealing cover 54 at the outlet of the No. 2 shell 52, when the gas needs to be discharged, the No. 2 spring 53 is stretched and the sealing cover 54 slides upward, thereby connecting the No. 2 shell 52 with the outside world. When the vacuum pump 51 stops running, the No. 2 spring 53 pulls the sealing cover 54 to seal the outlet of the No. 2 shell 52 to prevent air leakage.

[0063] like Figure 12As shown, the cooling mechanism 4 includes a cooling module 41, an air outlet pipe 42 and an air return pipe 43. The cooling module 41 is fixedly connected to the No. 1 shell 1, the air outlet pipe 42 is fixedly connected to the cooling module 41, the air return pipe 43 is fixedly connected to the cooling module 41, the air outlet pipe 42 is connected to the centrifugal chamber 7, and the air return pipe 43 is connected to the centrifugal chamber 7.

[0064] A small amount of cooling gas is input into the centrifugal chamber 7 through the air outlet pipe 42 through the cooling module 41, thereby cooling the inside of the centrifugal chamber 7 to prevent the rotor 24 from generating heat during high-speed rotation, which may cause the vaccine sample to denature or inactivate. The gas inside the centrifugal chamber 7 is extracted through the return air pipe 43, and after cooling in the cooling module 41, it is input into the centrifugal chamber 7 again through the air outlet pipe 42, thereby continuously cooling the inside of the centrifugal chamber 7.

[0065] Working principle: The operator places the tube containing the vaccine on the rotor 24 of the centrifugal chamber 7. The gas inside the centrifugal chamber 7 can be extracted through the vacuum pump 51, and the rotating shaft 22 is driven to rotate by the motor 21, driving the rotor 24 installed on the base 23 to rotate at an overspeed. The counterweight slider 312 slides along the annular groove 242, so that the counterweight slider 312 pushes the transmission rod 313 to rotate along the hinge, so that the cleaning structure retracts into the rotor 24. At the same time, the cooling module 41 inputs a small amount of cooling gas into the centrifugal chamber 7 through the outlet pipe 42, thereby cooling the inside of the centrifugal chamber 7, and cooperates with the return air pipe 43 to circulate the gas inside the centrifugal chamber 7, thereby continuously cooling the centrifugal chamber 7, thereby centrifugally separating the tube containing the vaccine on the rotor 24. After the separation is completed, the counterweight slider 312 is reset under the action of the annular spring 311 , the transmission rod 313 is reset under the action of the torsion spring, the vaccine sample is taken out, and the rotating shaft 22 is driven by the motor 21 to drive the rotor 24 to rotate at a low speed. The cleaning liquid is sprayed on the inner wall of the centrifugal chamber 7 through the spray unit 33, so that the scraper 36 and the brush 37 clean the inner wall of the centrifugal chamber 7. At the same time, according to the different viscosities of the pollutants, the scraper 36 can overcome the elastic force of the No. 1 spring 351 and slide along the guide rod 352, so that the scraper 36 fits more closely to the inner wall of the centrifugal chamber 7, thereby increasing the scraping force of the pollutants. Different currents are generated by the piezoelectric ceramic 353 at the bottom according to the compression force of the No. 1 spring 351. The current is transmitted to the control system through the electrode 354, so that the control system controls the water pump 331 according to the current generated by the piezoelectric ceramic 353, thereby controlling the flow of the cleaning liquid and discharging the sewage generated by the cleaning through the drain pipe 61.

[0066] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. An ultracentrifuge device for vaccine production with an internal cleaning function, characterized in that: The centrifugal device comprises a first housing (1), a centrifugal rotating mechanism (2), an adaptive cleaning mechanism (3), a cooling mechanism (4), a vacuum mechanism (5), a drainage mechanism (6) and a centrifugal chamber (7), wherein the first housing (1) and the centrifugal chamber (7) are fixedly connected, the centrifugal rotating mechanism (2) and the centrifugal chamber (7) are fixedly connected, the adaptive cleaning mechanism (3) and the centrifugal rotating mechanism (2) are fixedly connected, the cooling mechanism (4) and the centrifugal chamber (7) are fixedly connected, the vacuum mechanism (5) and the centrifugal chamber (7) are connected by a pipeline, and the drainage mechanism (6) and the centrifugal chamber (7) are fixedly connected; The adaptive cleaning mechanism (3) comprises a centrifugal contraction unit (31), a connecting rod (32), a spray unit (33), a fixing rod (34), an adjustment mechanism (35), a scraper (36) and a brush (37); The regulating mechanism (35) includes a No. 1 spring (351), a guide rod (352), a piezoelectric ceramic (353) and an electrode (354), wherein the No. 1 spring (351) is sleeved outside the guide rod (352), the guide rod (352) and the fixed rod (34) are fixedly connected, the guide rod (352) and the scraper (36) are slidably connected, the piezoelectric ceramic (353) and the fixed rod (34) are fixedly connected, the No. 1 spring (351) and the piezoelectric ceramic (353) are in contact, and the electrode (354) and the piezoelectric ceramic (353) are fixedly connected; The centrifugal rotating mechanism (2) includes a motor (21), a rotating shaft (22), a base (23) and a rotor (24); The rotor (24) is provided with a movable groove (241), the centrifugal contraction unit (31) is placed in the movable groove (241), the connecting rod (32) and the centrifugal contraction unit (31) are fixedly connected, the spray unit (33) and the connecting rod (32) are fixedly connected, the fixed rod (34) and the connecting rod (32) are fixedly connected, the adjusting mechanism (35) and the fixed rod (34) are fixedly connected, the scraper (36) and the adjusting mechanism (35) are slidably connected, and the brush (37) and the fixed rod (34) are rotatably connected; The centrifugal contraction unit (31) includes an annular spring (311), a counterweight slider (312) and a transmission rod (313); the rotor (24) is provided with an annular groove (242); the annular spring (311) is placed in the annular groove (242); the counterweight slider (312) and the annular spring (311) are fixedly connected; the transmission rod (313) and the counterweight slider (312) are movably connected; the transmission rod (313) and the connecting rod (32) are fixedly connected; the transmission rod (313) and the rotor (24) are hingedly connected; and the counterweight slider (312) and the annular groove (242) are slidably connected; By arranging an annular spring (311) and a counterweight slider (312) in the annular groove (242) of the rotor (24), when the rotor (24) rotates at a high speed, the counterweight slider (312) overcomes the pulling force of the annular spring (311) under the action of centrifugal force, the annular spring (311) is stretched, and the counterweight slider (312) slides along the annular groove (242), so that the counterweight slider (312) pushes the transmission rod (313), and the transmission rod (313) first rotates slowly along the hinge and then rotates quickly, so as to avoid damage to the cleaning component caused by excessive impact force during contraction. The torsion spring provided on the hinge of the transmission rod (313) is compressed, thereby causing the transmission rod (313) to contract to the movable groove (241). When the rotor (24) rotates at a low speed, the annular spring (311) contracts, and the counterweight slider (312) slides along the annular groove (242) to reset. At the same time, the torsion spring releases its elastic force, so that the transmission rod (313) rotates along the hinge to reset.

2. The ultracentrifuge device for vaccine production with internal cleaning function according to claim 1, characterized in that: The motor (21) is fixedly connected to the centrifugal chamber (7), the output end of the motor (21) is fixedly connected to the rotating shaft (22), the rotating shaft (22) is fixedly connected to the base (23), and the rotor (24) is tightly connected to the base (23).

3. The ultracentrifuge device for vaccine production with internal cleaning function according to claim 2, characterized in that: The spray unit (33) comprises a water pump (331), a rotary joint (332), a cleaning liquid tank (333) and a spray pipe (334); the water pump (331) and the rotary joint (332) are connected by a pipeline; the cleaning liquid tank (333) and the water pump (331) are connected by a pipeline; the spray pipe (334) and the rotary joint (332) are connected by a pipeline; and the spray pipe (334) and the connecting rod (32) are fixedly connected.

4. The ultracentrifuge device for vaccine production with internal cleaning function according to claim 3, characterized in that: The first spring (351) comprises a variable pitch helical section (3511) and a variable diameter helical section (3512); the variable pitch helical section (3511) and the scraper (36) are fixedly connected; the variable pitch helical section (3511) and the variable diameter helical section (3512) are fixedly connected; and the variable diameter helical section (3512) and the fixed rod (34) are fixedly connected.

5. The ultracentrifuge device for vaccine production with internal cleaning function according to claim 4, characterized in that: The drainage mechanism (6) comprises a drainage pipe (61), an electromagnetic coil (62), a return spring (63) and a slide (64); the drainage pipe (61) is fixedly connected to the centrifugal chamber (7); the drainage pipe (61) is provided with a liquid channel (611); the electromagnetic coil (62) is fixedly connected to the liquid channel (611); the return spring (63) is fixedly connected to the liquid channel (611); the slide (64) is slidably connected to the liquid channel (611); and the slide (64) is fixedly connected to the return spring (63).

6. The ultracentrifuge device for vaccine production with internal cleaning function according to claim 5, characterized in that: The vacuum mechanism (5) comprises a vacuum pump (51), a No. 2 housing (52), a No. 2 spring (53) and a sealing cover (54); the vacuum pump (51) is connected to the centrifugal chamber (7) via a pipeline; the No. 2 housing (52) is connected to the vacuum pump (51) via a pipeline; the No. 2 spring (53) is fixedly connected to the No. 2 housing (52); the sealing cover (54) is fixedly connected to the No. 2 spring (53); and the sealing cover (54) is in contact with the No. 2 housing (52).

7. The ultracentrifuge device for vaccine production with internal cleaning function according to claim 6, characterized in that: The cooling mechanism (4) includes a cooling module (41), an air outlet pipe (42) and an air return pipe (43); the cooling module (41) is fixedly connected to the first housing (1); the air outlet pipe (42) is fixedly connected to the cooling module (41); the air return pipe (43) is fixedly connected to the cooling module (41); the air outlet pipe (42) is in communication with the centrifugal chamber (7); and the air return pipe (43) is in communication with the centrifugal chamber (7).

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