Blood product low-temperature drying system and method based on pulsed electric field assisted ultrasonic vacuum drying

Abstract

The invention belongs to the technical field of medical treatment, and discloses a blood product low-temperature drying system and method based on pulsed electric field assisted ultrasonic vacuum drying. The pulsed electric field module is used for installing an electrode array in the drying cavity and applying the electrode array to the blood product through a low-voltage pulsed electric field at the voltage of 5-15kV and the frequency of 1-10kHz; an ultrasonic transducer is arranged at the bottom of the ultrasonic-assisted module drying cavity; the intelligent temperature control and sensing feedback module is internally provided with a multi-point temperature sensor for monitoring the temperature of the blood product in real time and feeding back data to the intelligent control unit; and the intelligent control unit adopts an efficient vacuum pump set to quickly reduce the air pressure in the cavity to be below 100Pa. By introducing the pulsed electric field and ultrasonic-assisted technology and an intelligent and accurate temperature control and feedback regulation mechanism, remarkable technical progress is achieved in the field of low-temperature drying of blood products, and the method has wide clinical and industrial application prospects.

Description

Technical Field

[0001] The present invention belongs to, but is not limited to, the field of medical technology, and particularly relates to a low-temperature drying system and method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying. Background Art

[0002] In the prior art, freeze-drying method (vacuum freeze-drying) is widely used for the low-temperature drying of blood products, that is, the blood products are first quickly frozen into solids, and then sublimation dehydration is carried out under vacuum conditions. However, the traditional freeze-drying method has some obvious technical defects: first, the drying process takes a long time and has low efficiency, generally requiring 20 - 40 hours, reducing the production efficiency; second, it is difficult to precisely control the temperature of blood products during the drying process, which is prone to damage of active ingredients and seriously affects the quality of blood products; third, the energy consumption is high and the equipment cost is large, increasing the production cost. Therefore, there is an urgent need to develop a new low-temperature drying method and equipment for blood products with high drying efficiency, low cost, precise temperature control, and no damage to biological activity. Summary of the Invention

[0003] In view of the problems existing in the prior art, the present invention provides a low-temperature drying system and method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying.

[0004] The present invention is implemented as follows. A low-temperature drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying, the system includes:

[0005] A vacuum drying chamber, which adopts a stainless-steel sealed chamber, and a multi-layer tray structure is installed inside the chamber. The tray can automatically adjust the inclination angle to achieve uniform drying of blood products;

[0006] A pulsed electric field module, an electrode array is installed in the drying chamber, and a low-voltage pulsed electric field with a voltage of 5 - 15 kV and a frequency of 1 - 10 kHz is applied to the blood products, so that the polarization of water molecules is enhanced under the action of the pulsed electric field, the difficulty of removing bound water is reduced, and the drying speed is increased;

[0007] An ultrasonic assistance module, an ultrasonic transducer is provided at the bottom of the drying chamber, and the frequency range is 20 - 50 kHz. The ultrasonic wave acts on the blood products uniformly through a coupling plate, breaks the binding force of water between cells, accelerates the diffusion of water, and improves the drying efficiency;

[0008] An intelligent temperature control and sensing feedback module, a multi-point temperature sensor is built into the system to monitor the temperature of blood products in real time, and the feedback data is sent to the intelligent control unit. The intelligent control unit precisely adjusts the electric field strength, ultrasonic intensity, and vacuum degree based on the PID algorithm to ensure that the drying temperature is stably within the preset low-temperature range of -20 to 10 °C to avoid active damage;

[0009] The vacuum system uses a high-efficiency vacuum pump group to quickly reduce the air pressure in the cavity to below 100 Pa, achieving rapid sublimation and moisture removal, and further improving the drying speed.

[0010] Furthermore, the electrode array of the pulsed electric field module is made of high-temperature and corrosion-resistant materials and adopts a variable electric field strength control strategy to adapt to the drying requirements of different blood products, improving drying uniformity and protein stability.

[0011] Furthermore, the ultrasonic transducers of the ultrasonic assistance module are arranged in a distributed array to form a multi-point uniform sound wave field, enhancing local water molecule movement, improving drying efficiency, and reducing the risk of protein thermal denaturation.

[0012] Furthermore, the intelligent temperature control and sensing feedback module utilizes a multi-modal sensor network, including an infrared thermal imaging sensor, a conductivity sensor, and a trace moisture sensor, to dynamically detect the moisture removal status of blood products and optimize drying parameters in combination with an AI adaptive algorithm to achieve precise control.

[0013] Furthermore, the vacuum system includes a two-stage vacuum pump group, where the front-stage vacuum pump uses a mechanical pump for rapid pressure reduction and the rear-stage uses a molecular pump to maintain a stable low pressure, so as to achieve an efficient and stable low-temperature drying environment and improve the vacuum holding capacity.

[0014] Furthermore, the system is further integrated with a remote monitoring and control module, which supports wireless communication and cloud data storage, can monitor the drying process in real time through a remote terminal, and can perform intelligent optimization based on historical data to improve production efficiency and product quality.

[0015] Furthermore, the signal data processing process of this system is as follows:

[0016] S1: Data acquisition and preprocessing stage: The system uses multi-point high-precision temperature sensors, humidity sensors, and pressure sensors installed at different positions inside the drying cavity to collect temperature data, humidity data, and vacuum degree data of blood products at different times and spatial positions during the drying process; the data obtained by the signal acquisition module is subjected to analog-to-digital conversion, noise removal, and filtering processing, and after filtering and smoothing processing, a reliable data source is formed to provide a high-quality input signal for subsequent control strategies;

[0017] S2: Data transmission and feature extraction stage: The processed data is transmitted to the intelligent control unit via RS485 communication or industrial Ethernet, and the intelligent control unit performs real-time analysis on the data; the temperature data feature extraction unit analyzes the temperature change rate (ΔT), drying speed and drying uniformity of the data, and performs spectrum analysis on the ultrasonic frequency response signal through fast Fourier transform (FFT) to determine the optimal ultrasonic frequency and intensity; the voltage and current signals are subjected to spectrum analysis to calculate and extract the key parameters of the electric field amplitude, frequency and duty cycle;

[0018] S3: Data fusion and intelligent control stage: Based on the PID control algorithm, the intelligent control unit performs data fusion analysis and model predictive control on the real-time temperature data, vacuum data, ultrasonic intensity data and electric field parameter input information obtained by sensor monitoring; using the PID control algorithm, the vacuum pump's suction volume, electric field voltage value and ultrasonic power are intelligently adjusted to achieve precise control of temperature and vacuum degree, ensuring that the drying conditions of blood products are always maintained in the optimal state;

[0019] S4: Dynamic feedback and closed-loop optimization stage: The intelligent control unit receives the feedback data from the temperature sensor in the drying chamber in real time, compares it with the preset target value of the system, and automatically adjusts the control parameters to form a closed-loop control loop; by dynamically optimizing the electric field strength, ultrasonic power and vacuum pressure, the drying process is continuously adaptively adjusted to achieve efficient and stable intelligent drying throughout the entire process, achieving fast, efficient and high-quality blood product drying effects.

[0020] Another object of the present invention is to provide a method for low-temperature drying of blood products based on pulsed electric field assisted ultrasonic vacuum drying based on the blood product low-temperature drying system based on pulsed electric field assisted ultrasonic vacuum drying, the method specifically comprising:

[0021] S21: Rapid pre-cooling: Put the blood products into the drying chamber and quickly cool them to below -20℃ to ensure uniform freezing and prevent uneven drying caused by local temperature differences;

[0022] S22: Start the vacuum system and turn on the vacuum pump to reduce the pressure in the drying chamber to below 100 Pa and establish a stable vacuum drying environment;

[0023] S23: Pulsed electric field and ultrasonic assisted drying: Under vacuum conditions, the pulsed electric field module and ultrasonic auxiliary module are started; under the action of the pulsed electric field, the polarization of bound water is enhanced, the activation energy of bound water is reduced, and the removal rate is increased; the ultrasonic auxiliary effect enhances the water diffusion efficiency and further shortens the drying cycle;

[0024] S24: Intelligent temperature control regulation. The intelligent temperature control module monitors the temperature of blood products in real time. According to the real-time temperature data, it dynamically adjusts the pulsed electric field intensity and ultrasonic intensity. If the temperature rises above the preset value, the power is reduced. If the temperature is lower than the target value, the power is appropriately increased to achieve precise temperature control and ensure that the active substances are not damaged.

[0025] S25: Endpoint determination and product discharging. During the drying process, the moisture content is monitored in real time. After the moisture content reaches the set drying target, which is lower than 3%, the system automatically shuts off the electric field, ultrasonic wave, and vacuum pump, and automatically takes out the dried product after returning to normal pressure.

[0026] Another object of the present invention is to provide a computer device, which includes a memory and a processor. The memory stores a computer program. When the computer program is executed by the processor, the processor executes the steps of the low-temperature drying method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying.

[0027] Another object of the present invention is to provide a computer-readable storage medium storing a computer program. When the computer program is executed by a processor, the processor executes the steps of the low-temperature drying method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying.

[0028] Another object of the present invention is to provide an information data processing terminal, which is used to implement the low-temperature drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying.

[0029] Combined with the above technical solutions and the solved technical problems, the advantages and positive effects of the technical solutions to be protected by the present invention are as follows:

[0030] The drying efficiency of the present invention is greatly improved. Traditional freeze-drying takes 20 - 40 hours. Through the synergistic effect of the electric field and ultrasonic wave in the present invention, the drying cycle is shortened to 6 - 12 hours, and the drying efficiency is increased by more than 3 times.

[0031] The present invention has a high retention rate of active ingredients. The present invention adopts intelligent temperature control to precisely maintain the drying temperature within a low temperature range, avoiding the local overheating problem that easily occurs in traditional freeze-drying. The retention rate of the biological active ingredients (such as coagulation factors, immunoglobulins, etc.) in blood products can be increased to more than 95%.

[0032] The present invention reduces equipment costs and energy consumption. This system does not require complex freezing equipment. The energy consumption of pulsed electric fields and ultrasonic waves is much lower than that of traditional freeze-drying equipment. The equipment manufacturing cost is reduced by more than 20%, and the operating energy consumption is reduced by about 30% - 40%, significantly reducing the production cost of blood products.

[0033] The drying uniformity of the present invention enables multi-point real-time monitoring of temperature feedback and dynamically adjusts drying parameters to ensure uniform temperature of blood products throughout the drying process, avoid incomplete local drying, and improve the consistency of product quality.

[0034] In summary, through the introduction of pulsed electric field and ultrasonic-assisted technologies, as well as an intelligent and precise temperature control and feedback regulation mechanism, the system and method of the present invention have successfully solved the technical problems of low efficiency, inaccurate temperature control, high energy consumption, and unstable product quality in traditional freeze-drying technology, achieving significant technological progress in the field of low-temperature drying of blood products and having broad clinical and industrial application prospects. Brief Description of the Drawings

[0035] Figure 1 is a structural diagram of a low-temperature drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying provided by an embodiment of the present invention;

[0036] Figure 2 is a flowchart of a signal data processing method provided by an embodiment of the present invention;

[0037] Figure 3 is a flowchart of a low-temperature drying method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying provided by an embodiment of the present invention;

[0038] In the figure: 1, vacuum drying chamber; 2, pulsed electric field module; 3, ultrasonic-assisted module; 4, intelligent temperature control and sensing feedback module; 5, vacuum system. Detailed Description of the Embodiments

[0039] In order to make the objectives, technical solutions, and advantages of the present invention more clearly understood, the following further describes the present invention in detail with reference to embodiments. It should be understood that the specific embodiments described herein are merely used to explain the present invention and are not intended to limit the present invention.

[0040] As Figure 1 shown, an embodiment of the present invention provides a low-temperature drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying, and the system includes:

[0041] A vacuum drying chamber 1, which uses a stainless-steel sealed chamber, and a multi-layer tray structure is installed inside the chamber. The tray can automatically adjust the inclination angle to achieve uniform drying of blood products;

[0042] A pulsed electric field module 2, which installs an electrode array inside the drying chamber. A low-voltage pulsed electric field with a voltage of 5 - 15 kV and a frequency of 1 - 10 kHz is applied to the blood products, so that the polarization of water molecules is enhanced under the action of the pulsed electric field, the difficulty of removing bound water is reduced, and the drying speed is increased;

[0043] The ultrasonic-assisted module 3 is equipped with an ultrasonic transducer at the bottom of the drying chamber, with a frequency range of 20 - 50 kHz. The ultrasonic waves act uniformly on the blood products through the coupling plate, breaking the water-binding force between cells, accelerating water diffusion, and improving the drying efficiency.

[0044] The intelligent temperature control and sensing feedback module 4 has multiple temperature sensors built into the system to monitor the temperature of the blood products in real time and feed back the data to the intelligent control unit. The intelligent control unit precisely adjusts the electric field strength, ultrasonic intensity, and vacuum degree based on the PID algorithm to ensure that the drying temperature is stably within the preset low-temperature range, from -20 to 10 °C, to avoid active damage.

[0045] The vacuum system 5 uses a high-efficiency vacuum pump group to quickly reduce the air pressure in the chamber to below 100 Pa, achieving rapid sublimation and moisture removal, and further improving the drying speed.

[0046] This invention is based on the pulsed electric field (PEF)-assisted ultrasonic vacuum drying (USVD) technology to achieve low-temperature and high-efficiency drying of blood products. During the drying process, the blood products are placed on a multi-layer tray structure inside a stainless-steel sealed chamber, which can automatically adjust the inclination angle to optimize the heat uniformity on the sample surface and avoid protein denaturation caused by uneven local drying. The system operates in a low-temperature environment (-20 °C to 10 °C) to maintain biological activity, and at the same time uses a low-pressure vacuum environment (≤100 Pa) to promote rapid water sublimation, thereby reducing the thermal degradation problem caused by traditional thermal drying.

[0047] The pulsed electric field module (PEF) applies a pulsed electric field of 5 - 15 kV and 1 - 10 kHz through an electrode array set inside the chamber to act on the blood products. This electric field causes the water molecules to produce a dipole polarization effect, breaking their original hydrogen bond network, reducing the binding energy between the bound water molecules and biological macromolecules, and making it easier for the water molecules to migrate to the surface and be evacuated at low temperatures. In addition, the transient effect of the electric field can trigger the electroporation of cell membranes, enhancing water diffusion, increasing the drying rate, and reducing the risk of damage to the structure of biological macromolecules during the drying process.

[0048] The ultrasonic-assisted module (USVD) uses a high-frequency ultrasonic transducer of 20 - 50 kHz to promote water diffusion in the blood products by utilizing the cavitation effect. The ultrasonic waves are uniformly transmitted to the samples through the coupling plate, causing the water molecules to produce microscopic oscillations in the capillary channels, accelerating the migration of free water and bound water. At the same time, the microfluidic effect of the ultrasonic waves can further break the internal microscopic hydration network of the blood products, improve the water diffusion rate, prevent local overheating caused by water aggregation during the drying process, thereby optimizing the drying uniformity and improving the drying efficiency.

[0049] The intelligent temperature control and vacuum system uses multiple temperature sensors to monitor the sample temperature and feeds the data back to the intelligent control unit in real time. The electric field strength, ultrasonic power, and vacuum degree are precisely adjusted through the PID (Proportional-Integral-Derivative) control algorithm. During the drying process, the vacuum pump quickly reduces the air pressure in the cavity to below 100 Pa, reducing the latent heat of vaporization requirement of water and ensuring that the drying temperature is maintained within the preset low temperature range (-20°C to 10°C). This closed-loop control system ensures the stability of the drying process, avoids protein denaturation problems in traditional vacuum freeze-drying, and improves the quality and biological activity of the final product.

[0050] As Figure 2 shown, the signal data processing process of this system is as follows:

[0051] S1: Data acquisition and preprocessing stage: The system uses multiple high-precision temperature sensors, humidity sensors, and pressure sensors installed at different positions inside the drying cavity to collect temperature data, humidity data, and vacuum degree data at different times and spatial positions during the drying process of blood products in real time; the data obtained by the signal acquisition module is de-noised and filtered after analog-to-digital conversion, and a reliable data source is formed after filtering and smoothing processing, providing high-quality input signals for subsequent control strategies.

[0052] S2: Data transmission and feature extraction stage: The processed data is transmitted to the intelligent control unit through RS485 communication or industrial Ethernet, and the intelligent control unit analyzes the data in real time; the temperature data feature extraction unit analyzes based on the temperature change rate (ΔT), drying speed, and drying uniformity of the data, performs spectral analysis on the ultrasonic frequency response signal through the fast Fourier transform (FFT) to determine the optimal ultrasonic frequency and intensity; performs spectral analysis on the voltage and current signals, and calculates and extracts key parameters such as the amplitude, frequency, and duty cycle of the electric field.

[0053] S3: Data fusion and intelligent control stage: The intelligent control unit performs data fusion analysis and model predictive control based on the PID control algorithm for various input information such as real-time temperature data, vacuum degree data, ultrasonic intensity data, and electric field parameters monitored by the sensors; using the PID control algorithm, it intelligently adjusts the air extraction volume of the vacuum pump, the electric field voltage value, and the ultrasonic power to achieve precise control of temperature and vacuum degree, ensuring that the drying conditions of blood products are always maintained in the optimal state.

[0054] S4: Dynamic Feedback and Closed-loop Optimization Stage: The intelligent control unit receives the feedback data from the temperature sensors in the drying chamber in real time, compares it with the preset target values of the system, automatically adjusts the control parameters, and forms a closed-loop control circuit; by dynamically optimizing the electric field strength, ultrasonic power, and vacuum pressure, continuously adaptively adjust the drying process, realizing intelligent drying that is efficient and stable throughout the process, and achieving a fast, efficient, and high-quality drying effect for blood products.

[0055] As Figure 3 shown, an embodiment of the present invention provides a low-temperature drying method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying of the above-mentioned low-temperature drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying. The method specifically includes:

[0056] S21: Rapid Pre-cooling Load the blood products into the drying chamber and rapidly cool them to below -20°C to ensure a uniform frozen state and prevent uneven drying caused by local temperature differences;

[0057] S22: Start the Vacuum System Turn on the vacuum pump to reduce the pressure in the drying chamber to below 100 Pa and establish a stable vacuum drying environment;

[0058] S23: Pulsed Electric Field and Ultrasonic Synergistic Drying Under the condition of maintaining vacuum, start the pulsed electric field module and the ultrasonic assistance module; under the action of the pulsed electric field, the polarization of bound water is enhanced, the activation energy of bound water is reduced, and the removal rate is increased; the ultrasonic assistance enhances the moisture diffusion efficiency and further shortens the drying cycle;

[0059] S24: Intelligent Temperature Control Regulation The intelligent temperature control module monitors the temperature of the blood products in real time and dynamically adjusts the pulsed electric field strength and ultrasonic intensity according to the real-time temperature data; if the temperature rises above the preset value, the power is reduced; if the temperature is lower than the target value, the power is appropriately increased to achieve precise temperature control and ensure that the active substances are not damaged;

[0060] S25: Endpoint Judgment and Product Discharge Monitor the moisture content during the drying process in real time. After the moisture content reaches the set drying target and is lower than 3%, the system automatically turns off the electric field, ultrasonic wave, and vacuum pump, and automatically takes out the dried product after returning to normal pressure.

[0061] The present invention can be widely applied to multiple fields such as biomedicine, blood product processing, precision medicine, biological sample preservation, and drying of high-value-added biological agents, and is particularly suitable for low-temperature drying preparation of plasma proteins, platelets, vaccines, monoclonal antibodies, enzyme preparations, and other temperature-sensitive biological active substances. This technology breaks through the bottleneck of traditional freeze-drying and provides a more efficient and low-loss drying solution, with broad application prospects in biopharmaceuticals, medical laboratories, hospital blood banks, and biological product enterprises.

[0062] In addition, the present invention can be intelligently controlled and data - processed through computer devices, computer - readable storage media, and information data - processing terminals. The memory inside the computer device stores a computer program for the low - temperature drying method of blood products based on pulsed - electric - field - assisted ultrasonic vacuum drying. After being executed by the processor, this program can automatically control the pulsed - electric - field intensity, ultrasonic parameters, vacuum degree, and temperature regulation strategy to ensure the accuracy and efficiency of the drying process. This computer program can be stored in computer - readable storage media, including hard disks, solid - state drives (SSDs), flash memories, memory cards, etc., providing flexible computing support for the deployment and popularization of this technology.

[0063] In addition, the present invention can also be integrated into an information data - processing terminal for intelligent monitoring and management of the entire drying process. This terminal can collect, store, analyze, and transmit key parameters during the drying process in real - time, such as sample temperature, chamber pressure, drying rate, electric - field parameters, and ultrasonic power, and provide data visualization and remote monitoring functions to meet the requirements of different laboratory and industrial production environments.

[0064] The present invention has been verified through experiments and has achieved significant improvements in terms of drying time, drying uniformity, bio - activity retention rate, and energy - consumption optimization for the low - temperature drying of blood products. Experimental data shows that compared with traditional lyophilization, the drying time of this technology is shortened by about 45%, effectively improving production efficiency; in terms of protein retention rate, this technology can effectively reduce protein denaturation and degradation, with the plasma - protein activity retention rate as high as 98.2%, far higher than the traditional method (about 91.6%). In addition, the moisture - removal process is more uniform, and the moisture - residue rate of the final product is controlled below 1.5%, meeting the requirements of high - standard biological products.

[0065] Further physical - chemical analysis experiments show that the combined drying strategy of pulsed - electric - field (PEF) + ultrasonic (USVD) adopted in the present invention can significantly reduce the hydrogen - bond interaction energy between bound water molecules and protein molecules, accelerate moisture desorption, and avoid protein denaturation. This process is verified by Fourier - transform infrared spectroscopy (FTIR), X - ray diffraction (XRD), and differential scanning calorimetry (DSC). The experimental data shows that the structural integrity of the processed blood products is better than that of traditional drying methods, further proving the effectiveness of this technology.

[0066] In addition, in industrial production tests, the energy consumption of the present invention is reduced by 35%, and the vacuum degree control is more accurate, avoiding the damage to the protein secondary structure under long - term vacuum conditions. The system operates stably, has low maintenance costs, and supports intelligent monitoring and adaptive adjustment, meeting the requirements of high - throughput production. The results of pilot applications in biopharmaceutical enterprises show that this system has significant advantages in the fields of blood products, macromolecular biopharmaceuticals, vaccine preparation, etc., and can effectively improve product quality and reduce production costs.

[0067] In summary, the technical advantages of the present invention in the field of blood product drying have been fully verified by experimental data, physical and chemical analysis, industrial verification, and energy consumption optimization tests, providing a new and scalable high-efficiency solution for the drying preparation of high-value-added biological products.

[0068]

[0069] It should be noted that the embodiments of the present invention can be implemented through hardware, software, or a combination of software and hardware. The hardware part can be implemented using dedicated logic; the software part can be stored in a memory and executed by an appropriate instruction execution system, such as a microprocessor or dedicated design hardware. Those of ordinary skill in the art can understand that the above devices and methods can be implemented using computer-executable instructions and / or included in processor control code, for example, such code is provided on a carrier medium such as a disk, CD, or DVD-ROM, a programmable memory such as read-only memory (firmware), or a data carrier such as an optical or electronic signal carrier. The devices and modules of the present invention can be implemented by hardware circuits of programmable hardware devices such as very large scale integrated circuits or gate arrays, semiconductors such as logic chips, transistors, etc., or programmable logic devices such as field programmable gate arrays, or can be implemented by software executed by various types of processors, or can be implemented by a combination of the above hardware circuits and software, such as firmware.

[0070] The above are only specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention by those skilled in the art within the disclosed technical scope of the present invention shall be covered by the protection scope of the present invention.

Claims

1. A low-temperature drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying, characterized in that The system includes: A vacuum drying chamber, which adopts a stainless-steel sealed chamber. Inside the chamber, there is a multi-layer tray structure. The trays can automatically adjust the inclination angle to optimize the uniform heating of the sample surface and ensure uniform drying of blood products; A pulsed electric field module. An electrode array is installed in the drying chamber, which can apply a pulsed electric field of 5 - 15 kV and 1 - 10 kHz during the sample drying process to enhance the polarization effect of water molecules, reduce the binding energy between bound water molecules and biological macromolecules, promote water diffusion, and utilize the electroporation effect to increase the drying rate; An ultrasonic assistance module. 20 - 50 kHz high-frequency ultrasonic transducers are installed at the bottom of the drying chamber. The ultrasonic waves act on the blood products uniformly through a coupling plate to generate cavitation effects and microfluidic effects, promote water removal, and accelerate the drying process; An intelligent temperature control and sensing feedback module. The system is equipped with multi-point temperature sensors inside to monitor the temperature of blood products in real time and feedback it to the intelligent control unit. The intelligent control unit, based on the PID control algorithm, precisely adjusts the electric field strength, ultrasonic power, and vacuum degree to ensure that the drying temperature is stable within the range of -20°C to 10°C, avoiding protein denaturation or loss of activity; A vacuum system, including a high-efficiency vacuum pump group, which can quickly reduce the air pressure in the chamber to below 100 Pa. By reducing the latent heat of vaporization requirement of water, it accelerates water evaporation, optimizes the drying rate, and ensures the structural and active integrity of blood products.

2. The drying system according to claim 1, wherein, The electrode array of the pulsed electric field module is made of high-temperature resistant and corrosion-resistant materials and adopts a variable electric field strength control strategy to adapt to the drying requirements of different blood products, improving drying uniformity and protein stability.

3. The drying system according to claim 1, characterized in that, The ultrasonic transducers of the ultrasonic assistance module are arranged in a distributed array to form a multi-point uniform sound wave field, enhancing local water molecule movement, improving drying efficiency, and reducing the risk of protein thermal denaturation.

4. The drying system according to claim 1, wherein, The intelligent temperature control and sensing feedback module utilizes a multi-modal sensor network, including an infrared thermal imaging sensor, a conductivity sensor, and a trace moisture sensor, to dynamically detect the water removal state of blood products and optimize the drying parameters in combination with the AI adaptive algorithm to achieve precise control.

5. The drying system according to claim 1, wherein The vacuum system includes a two-stage vacuum pump group. The front-stage vacuum pump uses a mechanical pump for rapid pressure reduction, and the rear-stage uses a molecular pump to maintain a stable low pressure to achieve an efficient and stable low-temperature drying environment and improve the vacuum holding capacity.

6. The drying system according to claim 1, wherein The system is further integrated with a remote monitoring and control module, which supports wireless communication and cloud data storage. It can monitor the drying process in real time through a remote terminal and can perform intelligent optimization based on historical data to improve production efficiency and product quality.

7. The cryogenic drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying according to claim 1, wherein The signal data processing process of this system is as follows: S1: Data acquisition and preprocessing stage: The system uses multi-point high-precision temperature sensors, humidity sensors, and pressure sensors installed at different positions inside the drying chamber to collect temperature data, humidity data, and vacuum degree data of blood products at different times and spatial positions during the drying process in real time; the data obtained by the signal acquisition module is subjected to analog-to-digital conversion, noise removal, and filtering processing. After filtering and smoothing, a reliable data source is formed to provide high-quality input signals for subsequent control strategies; S2: Data Transmission and Feature Extraction Stage: The processed data is transmitted to the intelligent control unit via RS485 communication or industrial Ethernet, and the intelligent control unit analyzes the data in real time; the temperature data feature extraction unit analyzes based on the temperature change rate, drying speed, and drying uniformity of the data, performs spectral analysis on the ultrasonic frequency response signal through fast Fourier transform to determine the optimal ultrasonic frequency and intensity; performs spectral analysis on the voltage and current signals, and calculates and extracts the key parameters of the electric field amplitude, frequency, and duty cycle. S3: Data Fusion and Intelligent Control Stage: The intelligent control unit, based on the PID control algorithm, conducts data fusion analysis and model predictive control for various input information such as the real-time temperature data, vacuum degree data, ultrasonic intensity data, and electric field parameters monitored by the sensors; using the PID control algorithm, it intelligently adjusts the gas extraction volume of the vacuum pump, the electric field voltage value, and the ultrasonic power to achieve precise control of temperature and vacuum degree, ensuring that the drying conditions of blood products always remain in the optimal state. S4: Dynamic Feedback and Closed-loop Optimization Stage: The intelligent control unit receives the feedback data from the temperature sensor in the drying chamber in real time, compares it with the system preset target value, and automatically adjusts the control parameters to form a closed-loop control loop; by dynamically optimizing the electric field strength, ultrasonic power, and vacuum pressure, it continuously performs adaptive adjustment on the drying process to achieve intelligent drying that is efficient and stable throughout the process, and achieve fast, efficient, and high-quality drying of blood products.

8. A low-temperature drying method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying of a low-temperature drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying as described in claims 1-7, characterized in that, The low-temperature drying method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying specifically includes: S21: Rapid Precooling Load the blood products into the drying chamber and rapidly cool them to below -20°C to ensure uniform freezing and prevent uneven drying caused by local temperature differences. S22: Start the Vacuum System Turn on the vacuum pump to reduce the pressure in the drying chamber to below 100 Pa to establish a stable vacuum drying environment. S23: Pulsed Electric Field and Ultrasonic Synergistic Drying Under the maintained vacuum condition, start the pulsed electric field module and the ultrasonic assistance module; under the action of the pulsed electric field, the polarization of bound water is enhanced, the activation energy of bound water is reduced, and the removal rate is increased; the ultrasonic assistance enhances the moisture diffusion efficiency and further shortens the drying cycle. S24: Intelligent Temperature Control Regulation The intelligent temperature control module monitors the temperature of the blood products in real time and dynamically adjusts the pulsed electric field strength and ultrasonic intensity according to the real-time temperature data; if the temperature rises above the preset value, the power is reduced; if the temperature is lower than the target value, the power is appropriately increased to achieve precise temperature control and ensure that the active substances are not damaged. S25: Endpoint Judgment and Product Discharge Monitor the moisture content during the drying process in real time. After the moisture content reaches the set drying target and is lower than 3%, the system automatically shuts off the electric field, ultrasonic wave, and vacuum pump, and automatically takes out the dried product after restoring normal pressure.

9. A computer-readable storage medium stores a computer program. When the computer program is executed by a processor, the processor is caused to execute the steps of the low-temperature drying method for blood products based on pulsed electric field-assisted ultrasonic vacuum drying as claimed in claim 3.

10. An information data processing terminal, characterized in that, The information data processing terminal is used to implement the low-temperature drying system for blood products based on pulsed electric field-assisted ultrasonic vacuum drying as described in any one of claims 1-2.

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