Medical implant and medical system

Abstract

The invention provides a medical implant and a medical system.The medical implant comprises a latticed structure formed by weaving a plurality of wires, and at least part of the wires are drainage wires; a liquid injection opening is formed in the end face of at least one end of the liquid guide wire; the liquid guide wire is provided with a liquid guide cavity which extends in the axial direction of the liquid guide wire and communicates with the liquid injection opening; and a spraying hole communicated with the liquid guide cavity is further formed in the side wall of the liquid guide wire material. The medical implant is used for being implanted into the body of a patient and covering a tumor neck opening of an aneurysm, a liquid embolism agent is injected into the liquid guiding cavity through the liquid injection opening and is sprayed out from the spraying hole to form a filament, and the filament is at least attached to the surface of the area, covering the tumor neck opening, of the medical implant to form a covering film so as to enhance blocking of the tumor neck opening. According to the medical implant, the grid-shaped structure is arranged in the tumor cavity, cells are induced to climb, thrombus can be rapidly and stably formed in the tumor cavity, meanwhile, the grid-shaped structure is allowed to be woven and formed by few wires, the hardness of the medical implant is not too large during conveying, the pushing resistance is reduced, and conveying is convenient.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to a medical implant and a medical system. Background Art

[0002] Intracranial aneurysm is a common disease in neurosurgery and neurology. In its initial stage, it has no typical symptoms and only shows headache, blurred consciousness or drowsiness. When the aneurysm ruptures, it can cause subarachnoid hemorrhage, with a high disability rate and fatality rate, seriously threatening the life of patients.

[0003] Neurointerventional surgery can be used to treat intracranial aneurysms. The main treatment methods of neurointerventional surgery include coil embolization, flow diversion with a dense mesh stent, and intratumoral occlusion, etc. Among them, coil embolization may require multiple surgical interventions, and each intervention will cause damage to the patient. Moreover, coil embolization also has problems such as low embolization efficiency, long operation time, more radiation exposure for the operator and the patient, and the coil is prone to produce a mass effect and herniate out of the aneurysm. The dense mesh stent blood flow diversion device is used to be implanted into the parent artery and cover the aneurysm neck. The dense mesh stent blood flow diversion device has a high-density mesh coverage and has a strong blood flow guiding ability. Therefore, it can reshape the local blood flow, divert the blood flow impacting the aneurysm to the normal blood vessels, change the hemodynamics in the aneurysm and finally form a thrombus, thereby occluding the aneurysm. The treatment method of intratumoral occlusion interferes with the blood flow in the aneurysm neck entering the aneurysm, can strengthen the aneurysm wall strength, and can overcome the shortcomings of the traditional dense mesh stent blood flow diversion device.

[0004] Whether it is the dense mesh stent blood flow diversion device or the traditional occlusion instrument used in the aneurysm, in order to effectively disturb the blood flow at the aneurysm neck, a large number of braided wires are needed for braiding. This results in the dense mesh stent blood flow diversion device or the occlusion instrument being relatively hard during delivery, prone to straightening the blood vessels and causing spasm, and a large-sized pusher rod needs to be selected, and a microcatheter and an intermediate catheter with a higher hardness need to be equipped for support, which brings more risks and difficulties to the actual operation of the operator. Summary of the Invention

[0005] The purpose of the present invention is to provide a medical implant and a medical system, which can still effectively disturb the blood flow at the aneurysm neck with fewer braided wire materials, and then occlude the aneurysm.

[0006] To achieve the above-mentioned purpose, the present invention provides a medical implant, comprising a grid-like structure woven from a plurality of wires, and at least part of the wires are liquid-conducting wires; a liquid injection port is formed on the end surface of at least one end of the liquid-conducting wire, and the liquid injection port is located at the proximal end of the grid-like structure; the liquid-conducting wire also has a liquid-conducting cavity extending along its axial direction, and the liquid-conducting cavity is connected to the liquid injection port; and a spray hole connected to the liquid-conducting cavity is opened on the side wall of the liquid-conducting wire.

[0007] Optionally, the number of the liquid-conducting filaments is not less than 1 / 2 of the number of the filaments.

[0008] Optionally, the number of the wires is 24 to 48.

[0009] Optionally, a plurality of ejection hole groups are provided on the side wall of the liquid-conducting wire, and the plurality of ejection hole groups are arranged at intervals along the circumference of the liquid-conducting wire; each of the ejection hole groups includes a plurality of the ejection holes, and all the ejection holes of the same ejection hole group are arranged at intervals along the axial direction of the liquid-conducting wire.

[0010] Optionally, the medical implant comprises a target area, and the target area is used to cover the neck of the aneurysm; the ejection hole is at least arranged in a portion of the liquid-conducting wire material located in the target area.

[0011] Optionally, the outer diameter of the wire is 0.05 mm to 0.1 mm; the inner diameter of the liquid-conducting wire is 0.04 mm to 0.08 mm; and the aperture of the ejection hole is 0.01 mm to 0.02 mm.

[0012] Optionally, the medical implant is a medical embolization material or a medical stent.

[0013] To achieve the above-mentioned purpose, the present invention also provides a medical system, comprising a push rod and the medical implant as described above, wherein the distal end of the push rod is connected to the proximal end of the medical implant, and the push rod is provided with an injection channel extending through it along its axial direction, and the injection channel is connected to the liquid conducting cavity of all the liquid conducting wires through the injection ports of all the liquid conducting wires.

[0014] Optionally, the ends of all the liquid-conducting wires provided with the liquid injection ports are retracted and embedded in the distal end of the liquid injection channel.

[0015] Optionally, a liquid embolic agent is further included, and the liquid embolic agent is used to enter the liquid guiding cavity through the injection channel and the injection port, and is sprayed out from the spray hole. The sprayed liquid embolic agent solidifies to form a filament, and the filament is attached to at least a portion of the surface of the medical implant to form a coating.

[0016] Optionally, the liquid embolizing agent includes at least one of polyvinyl alcohol, ethylene-vinyl alcohol copolymer, and n-butyl α-cyanoacrylate.

[0017] Compared with the prior art, the medical implant and medical system of the present invention have the following advantages:

[0018] The aforementioned medical implant includes a grid-like structure woven from multiple filaments, and at least some of the filaments are liquid-conducting filaments; a liquid injection port is formed on the end surface of at least one end of the liquid-conducting filament, and the liquid injection port is located at the proximal end of the grid-like structure; the liquid-conducting filament also has a liquid-conducting cavity extending along its axial direction, and the liquid-conducting cavity is communicated with the liquid injection port; ejection holes communicated with the liquid-conducting cavity are also provided on the side wall of the liquid-conducting filament. The medical implant can be used for implantation into a patient's body, and a part of the area of the medical implant is used to cover the aneurysm neck orifice. After the medical implant is at least partially deployed in the body, a liquid embolizing agent is perfused into the liquid-conducting cavity through the liquid injection port, and the liquid embolizing agent is ejected from at least some of the ejection holes. The ejected liquid embolizing agent can form filaments and at least adhere to the surface of the area of the medical implant covering the aneurysm neck orifice to form a film. On the one hand, the film can enhance the occlusion at the aneurysm neck orifice to direct blood to normal blood vessels and reduce the impact of blood on the aneurysm. On the other hand, it can also induce the climbing of fibroblast cells and tissue cells and improve tissue reactivity to quickly and stably embolize the aneurysm cavity, so that a complete embolism is formed in the aneurysm cavity. That is to say, the medical implant actually serves as a carrier matrix for the film, and it acts together with the film to achieve the occlusion of the aneurysm, resulting in aneurysm thrombosis. Therefore, it is allowed that the grid-like structure is woven and formed by fewer filaments, so that the hardness of the medical implant during delivery is not too large, it is not easy to straighten blood vessels, and a pusher with a smaller size and a microcatheter with a smaller hardness can be used for delivery, reducing the risk during the operation of the operator. Description of the Drawings

[0019] The drawings are used to better understand the present invention and do not constitute an improper limitation to the present invention. Among them:

[0020] Figure 1 is a schematic diagram of the shape of the medical implant of the medical system provided by the present invention according to an embodiment when it is in the deployed state. The medical implant in the figure is a medical embolism;

[0021] Figure 2 is according to the present invention Figure 1 a schematic diagram of the medical system provided by the present invention when the liquid embolizing agent solidifies into filaments and adheres to a part of the surface of the medical implant during use. The medical implant in the figure is a medical embolism;

[0022] Figure 3It is a schematic diagram of the shape of the medical implant of the medical system provided by the present invention according to an embodiment when it is in the deployed state. Figure 3 The medical implant in Figure 1 is a medical embolism, and the deployed shape of this medical embolism is different from that of the medical embolism in

[0023] Figure 4 It is according to the present invention Figure 3 Schematic diagram of the formation of a film when the liquid embolizing agent solidifies into filaments and adheres to a part of the surface of the medical implant in the medical system provided.

[0024] Figure 5 It is a schematic diagram of the shape of the medical implant of the medical system provided by the present invention according to an embodiment when it is in the deployed state. Figure 3 The medical implant in Figure 1 and Figure 2 is a medical embolism, and the deployed shape of this medical embolism is different from that of the medical embolisms in

[0025] Figure 6 It is a schematic diagram of the shape of the medical implant of the medical system provided by the present invention according to an embodiment when it is in the deployed state. Figure 4 The medical implant in Figure 1 , Figure 3 and Figure 5 is a medical embolism, and the deployed shape of this medical embolism is different from that of the medical embolisms in

[0026] Figure 7 It is a schematic diagram of the medical implant of the medical system provided by the present invention according to an embodiment being packed into an aneurysm and a film being formed on the surface of its target area.

[0027] Figure 8 It is a schematic diagram of the structure of the medical implant provided by the present invention according to an embodiment. The medical implant shown in the figure is a medical stent.

[0028] Figure 9 It is a schematic diagram of the structure of the medical implant provided by the present invention according to an embodiment. The medical implant shown in the figure is a medical stent, and it has a different viewing orientation from Figure 7 ;

[0029] Figure 10 It is a schematic diagram when a film is formed on the surface of the medical implant provided by the present invention according to an embodiment. The medical implant shown in the figure is a medical stent.

[0030] Figure 11 It is a schematic diagram when a film is formed on the surface of the medical implant provided by the second embodiment of the present invention. The medical implant shown in the figure is a medical stent, and it has a different viewing orientation fromFigure 9 The observation directions are different;

[0031] Figure 12 It is a schematic diagram of a medical implant provided by an embodiment of the present invention being implanted into a flowing artery, and a film is formed on the surface of a partial area thereof to cover the aneurysm neck opening;

[0032] Figure 13 It is a schematic structural diagram of a liquid guiding wire of a medical implant of a medical system provided by an embodiment of the present invention;

[0033] Figure 14 It is a partial schematic diagram of a medical system provided by an embodiment of the present invention.

[0034] [Description of reference numerals is as follows]:

[0035] 10 - Medical implant, 11 - Main body segment, 12 - Auxiliary segment, 100 - Mesh structure, 101 - First mesh body, 102 - Second mesh body, 103 - Third mesh body, 104 - Fourth mesh body, 105 - Fifth mesh body, 110 - Liquid guiding wire, 111 - Liquid guiding cavity, 112 - Ejection hole, 20 - Pushing rod, 21 - Liquid injection channel, 30 - Film, 40 - Conductive wire, 41 - Electrochemical detachment point. Detailed implementation manners

[0036] The following uses specific specific examples to illustrate the implementation manners of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation manners. Various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the diagrams provided in this embodiment only illustrate the basic concept of the present invention in a schematic manner. Therefore, only the components related to the present invention are shown in the diagrams, rather than being drawn according to the number, shape, and size of the components in actual implementation. The types, quantities, and ratios of the components in actual implementation can be arbitrarily changed, and the component layout type may also be more complex.

[0037] In addition, each of the following description contents of the embodiments has one or more technical features. However, this does not mean that those who use the present invention must implement all the technical features in any one embodiment at the same time, or can only separately implement some or all of the technical features in different embodiments. In other words, on the premise that implementation is possible, those skilled in the art can, according to the disclosed content of the present invention and depending on the design specifications or implementation requirements, selectively implement some or all of the technical features in any one embodiment, or selectively implement the combination of some or all of the technical features in multiple embodiments, thereby increasing the flexibility when implementing the present invention.

[0038] As used in this specification, the singular forms "a", "an" and "the" include plural referents, and the plural form "plural" includes more than two referents, unless the context clearly indicates otherwise. As used in this specification, the term "or" is generally used in the sense of including "and / or", unless the context clearly indicates otherwise, and the terms "mounted", "connected" and "coupled" should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection. It may be a mechanical connection or an electrical connection. It may be directly connected or indirectly connected through an intermediate medium, and it may be the communication inside two components or the interaction relationship between two components. The relational terms such as "first", "second" etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations, nor do they indicate or imply relative importance or implicitly specify the quantity of the indicated technical features. It should be understood that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential" etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the indicated device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0039] The terms "distal end" and "proximal end" are described according to the relative positions and relative orientations of the respective elements and components of the medical device. Although non-limiting, the "distal end" is usually the end that first enters the patient's body during normal use of the medical device, and the "proximal end" is the end closer to the operator.

[0040] The object of the present invention is to provide a medical system, which includes a medical implant and a pusher rod. The pusher rod is used to push and at least partially release the medical implant to a target position related to an aneurysm in the patient's body, so that the medical implant covers the neck opening of the aneurysm, and based on the configuration characteristics of the pusher rod and the medical implant, a film is formed at least on the surface of the area where the medical implant covers the neck opening, so as to further block the neck opening by using the film and direct the blood to the normal blood vessels, promote the embolization of the aneurysm cavity, while ensuring the embolization effect, and also enabling the medical implant to be woven and formed with fewer wire materials, thereby making the medical implant have a smaller hardness during transportation and reducing the risk during transportation.

[0041] To make the objectives, advantages and features of the present invention more clear, the present invention will be further described in detail below with reference to the accompanying drawings. It should be noted that the drawings are all in a very simplified form and use non-precise scales, only for conveniently and clearly assisting in explaining the objectives of the embodiments of the present invention. The same or similar reference numerals in the drawings represent the same or similar components.

[0042] Please refer to Figures 1 to 13 , the medical system includes a medical implant 10 and a push rod 20. Among them, the medical implant 10 includes a grid-like structure 100 woven from multiple filaments. At least a part of the multiple filaments are liquid-conducting filaments 110. A liquid injection port (not shown in the figure) is formed on the end surface of at least one end of the liquid-conducting filament 110. The liquid injection port is located at the proximal end of the grid-like structure 100, that is, the end of the liquid-conducting filament 110 provided with the liquid injection port is located at the proximal end of the grid-like structure 100. The liquid-conducting filament 110 also has a liquid-conducting cavity 111 extending along its axial direction, and the liquid-conducting cavity 111 communicates with the liquid injection port. A spray hole 112 communicating with the liquid-conducting cavity 111 is also formed on the side wall of the liquid-conducting filament 110. It should be noted that if both ends of some of the liquid-conducting filaments 110 are located at the proximal end of the grid-like structure 100, then the liquid injection ports can be formed on both of these ends of the liquid-conducting filaments 110, that is, the liquid-conducting cavities 111 of these liquid-conducting filaments 110 extend axially through. If one end of some of the liquid-conducting filaments 110 is located at the proximal end of the grid-like structure 100 and the other end is located at the distal end of the grid-like structure 100, then the liquid injection ports are formed on the ends of these liquid-conducting filaments 110 located at the proximal end of the grid-like structure 100, and the liquid injection ports are not formed on the ends located at the distal end of the grid-like structure 100.

[0043] The distal end of the push rod 20 is connected to the proximal end of the medical implant 10. The push rod 20 is provided with a liquid injection channel 21 extending axially through, and the liquid injection channel 21 communicates with the liquid-conducting cavity 111 of the liquid-conducting filament 110 through the liquid injection port.

[0044] The medical implant 10 of the medical system is used to be implanted at a target position in a patient's body and is used to treat an aneurysm so that the aneurysm cavity is embolized. The push rod 20 is used to cooperate with a microcatheter (not shown in the figure) and an intermediate catheter (not shown in the figure) to transport and release the medical implant 10 at the target position, so that the medical implant 10 unfolds and at least covers the aneurysm neck opening. In this article, the area where the medical implant 10 covers the aneurysm neck opening is called the target area. In other words, the medical system is used in a neurointerventional surgery.

[0045] During the operation, the operator also injects a liquid embolizing agent into the liquid guiding cavity 111 through the liquid injection channel 21 on the pushing rod 20, and makes the liquid embolizing agent spray out from at least part of the ejection holes 112. After the liquid embolizing agent enters the blood from the ejection holes 112, the solvent therein diffuses into the blood, and the blood penetrates into the liquid embolizing agent, so that the concentration of the liquid embolizing agent reaches the critical concentration, and then precipitates and solidifies in the blood to form filaments, and at least partially adheres to the surface of the target area of the grid-like structure 100. It can be understood that due to the relatively high concentration of the liquid embolizing agent itself, after it sprays out from the ejection holes 112 and forms filaments, the distance between the filaments is short, and it can quickly adhere to the surface of the grid-like structure and is not washed away by the blood, thus forming a net-like object and gradually forming the film 30. On the one hand, the film 30 can enhance the occlusion of the aneurysm neck opening, direct the blood to the normal blood vessels, and reduce the impact of the blood on the aneurysm. On the other hand, it can also well induce the climbing of fibroblast cells and tissue cells, and also improve the tissue reaction activity to quickly and stably embolize the aneurysm cavity, so that a complete embolization is formed in the aneurysm cavity. That is to say, the medical implant 10 provided by the embodiment of the present invention can be used as the bearing matrix of the film 30 and cooperate with the film 30 to promote the embolization of the aneurysm cavity. This enables the grid-like structure 100 of the medical implant 10 to be woven and formed by fewer wire materials. Generally, the number of wire materials can be reduced to at least 75% of the prior art. For example, it can be reduced from 64 wires in the prior art to 48 wires, or even 32 wires, or even less. This makes the medical implant 10 have a smaller hardness during transportation, is not easy to straighten the blood vessels, and can be transported by a pushing rod with a smaller size and a microcatheter with a smaller hardness, making the transportation operation easier to achieve and reducing the operation risk of the operator. Moreover, the film 30 is formed in the patient's body and will not have an adverse impact on the transportation of the medical implant 10.

[0046] In practice, the liquid embolizing agent can be solidified within 1 - 2 s after spraying out from the ejection holes 112. With the cooperation of the grid-like structure 100, the relatively thin film 30 can be formed within 1 - 2 min.

[0047] It can be understood that in the embodiment of the present invention, it is preferably that the grid-like structure 100 has radiopacity to facilitate the operator to judge the current position and posture of the medical implant 10 during the operation. To achieve this purpose, it is preferred that at least part of the wire materials used to weave the grid-like structure 100 have radiopacity. In some implementation manners, all the wire materials are DFT wires. Those skilled in the art know that the materials of the DFT wires include nitinol alloy and platinum. In other implementation manners, part of the wire materials are made of shape memory alloy and part of the wire materials are made of developable metal wires. Optional shape memory alloys include but are not limited to nitinol alloy, and developable metal wires include but are not limited to platinum.

[0048] In practice, the number of the liquid-conducting filaments 110 is not less than 1 / 2 of the total number of the filaments. Optionally, the total number of the filaments is 24 to 48, and accordingly, the number of the liquid-conducting filaments 110 is at least 12 to 24.

[0049] Since the liquid-conducting cavity 111 is formed on the liquid-conducting wire 110 , the wire diameter of the liquid-conducting wire 110 (i.e., the outer diameter of the liquid-conducting wire 110 ) is slightly larger, specifically, it can be 0.05 mm to 0.1 mm, and the diameter of the liquid-conducting cavity 111 (i.e., the inner diameter of the liquid-conducting wire 110 ) can be 0.04 mm to 0.08 mm.

[0050] All of the ejection holes 112 may be divided into a plurality of ejection hole groups, each of which includes a plurality of ejection holes 112. All of the ejection hole groups are arranged at intervals along the circumference of the liquid-conducting wire 110, for example, arranged at equal intervals. All of the ejection holes 112 in the same ejection hole group are aligned in the circumferential direction of the liquid-conducting wire 110, and are arranged at intervals along the axial direction of the liquid-conducting wire 110.

[0051] The embodiment of the present invention has no particular restrictions on the specific orientation of the ejection hole group, as long as the liquid embolic agent can be ejected through at least part of the ejection holes and form the coating 30 on the surface of the medical implant 10 after the medical implant 10 is implanted in the target position. In the embodiment of the present invention, the outer peripheral surface of the liquid-conducting wire 110 can be divided into a first surface, a second surface and a third surface, wherein the first surface refers to the portion of the outer peripheral surface of the liquid-conducting wire 10 facing the inner cavity of the grid structure 100 (i.e., the inner surface of the grid structure 100), the second surface refers to the portion of the outer peripheral surface of the liquid-conducting wire 110 facing away from the inner cavity of the grid structure 100 (i.e., the outer surface of the grid structure 100); the third surface refers to the portion of the outer peripheral surface of the liquid-conducting wire 110 connecting the first surface and the second surface. In some embodiments, at least part of the ejection hole group is located on the first surface, in other embodiments, at least part of the ejection hole group is located on the second surface, and in still other embodiments, at least part of the ejection hole group is located on the third surface. Alternatively, a portion of the ejection hole group spans the first surface and the third surface, or a portion of the ejection hole group spans the second surface and the third surface. For the ejection holes at least partially located on the third side surface, the liquid embolic agent ejected therefrom is more likely to adhere to the surface of the target area of ​​the medical implant 10.

[0052] The number of the ejection hole groups is two, three, four or more, which is specifically set according to requirements. The distance between two adjacent ejection holes 112 in the same ejection hole group is 1 mm to 3 mm (that is, the distance between two adjacent sandblasting holes 112 in the axial direction is 1 mm to 3 mm). This is because if the distance between two adjacent ejection holes 112 in the axial direction is too small, there is a problem that the liquid guiding wire 110 is not easy to process. If the distance between two adjacent ejection holes 112 in the axial direction is too large, there is a problem that the formed filamentous object is difficult to form a continuous coating film 30. In addition, the aperture of the ejection hole 112 can be 0.01 mm to 0.02 mm.

[0053] As described above, the filamentous object formed by the liquid embolic agent adheres to at least the surface of the target area of the medical implant 10. Therefore, the ejection holes 112 are formed at least on the side wall of the part of the liquid guiding wire 110 located in the target area, so that the liquid embolic agent can be ejected and cured at the target area to form the coating film 30.

[0054] In some implementation manners, the medical implant 10 is a medical embolization object as Figures 1 to 6 shown. Thus, as Figure 7 shown, the target position is the aneurysm cavity. In this case, by forming the coating film 30 at least in the target area of the medical implant 10, it is possible to effectively block the aneurysm neck opening by using one medical implant 10 and the coating film 30 thereon, without using multiple medical implants 10. It avoids the possibility of damaging the patient caused by the multiple delivery processes required when using multiple medical implants, shortens the operation time, and reduces the time that the operator and the patient are exposed to X-rays, reducing the harm of X-rays to the operator and the patient.

[0055] It can be understood that the embodiment of the present invention has no special requirements for the shape of the medical embolization object when it is in the deployed state, as long as it is suitable for filling in the aneurysm cavity. For example, the shape of the grid-like structure 100 when it is in the deployed state is as Figure 1 shown, similar to a frustum of a cone. Or, the shape of the grid-like structure 100 when it is in the deployed state is the spiral shape as Figure 2 shown. Or, as Figure 3 shown, when the grid-like structure 100 is in the deployed state, the embolization body 100 includes a first grid body 101 and a second grid body 102 connected along the axial direction. The first grid body 101 and the second grid body 102 are both in the shape of a flat disc structure and have a relatively large outer diameter, and the outer diameter at the connection of the first grid body 101 and the second grid body 102 is smaller; or, as Figure 4As shown, the grid-like structure 100 includes a third grid body 103, a fourth grid body 104, and a fifth grid body 105 that are sequentially connected along its axis. When the embolism body 100 is in the deployed form, both the third grid body 103 and the fifth grid body 105 are wound into a spiral structure, and the second grid body 104 forms a planar arc-shaped structure with an arc length not exceeding one circle.

[0056] For the medical embolism as Figure 1 and Figure 5 shown, the target area can be determined as its proximal end face and proximal outer peripheral face during production (for the medical embolism as Figure 5 shown, the target area is the proximal end face of the second grid body 102 and at least a part of its outer peripheral face), so the ejection holes 112 can be provided only at the part of the liquid guiding wire 110 located in the target area.

[0057] For the medical embolism as Figure 3 and Figure 6 described, if the position of the target area is set during production, it will result in extremely high accuracy required for the release of the medical embolism, increasing the operation difficulty for the operator. Therefore, the position of the target area is generally not limited during the production process. In this case, it is preferred to provide the ejection holes 112 throughout the entire axial length of the liquid guiding wire 110 to ensure that when the medical embolism fills the aneurysm cavity and any suitable position thereof is used as the target area, the liquid embolizing agent can be ejected at the target area to form the film 30.

[0058] In some other implementation manners, the medical implant 10 is a medical stent as Figures 7 to 10 shown. Thus, as Figure 11 shown, the target position is the position corresponding to the aneurysm neck opening and its vicinity in the aneurysm-bearing artery.

[0059] The medical stent includes a main body segment 11 and auxiliary segments 12 located at both axial ends of the main body segment 11. Among them, a part of the area of the main body segment 11 is the target area. The medical stent has the same problem as the medical embolism as Figure 2 and Figure 4 shown. Here, it is preferred to provide the ejection holes on the side wall of the part of the liquid guiding wire 110 located in the main body segment 11.

[0060] To facilitate the operator to inject the liquid embolizing agent into all the liquid guiding cavities 112 of the liquid guiding wires 110 through the liquid injection channel 21 at one time. As Figure 14As shown, when connecting the medical implant 10 to the push rod 20, it is preferred that at least the ends of all the liquid guiding filaments 110 provided with the liquid injection ports are gathered together and embedded in the distal end of the liquid injection channel 21. In this way, the liquid injection ports of all the liquid guiding filaments 110 are located within the liquid injection channel 21 and communicate with the liquid injection channel 21. During actual production, the proximal ends of all the filaments can be gathered together and embedded in the distal end of the liquid injection channel 21.

[0061] Among them, for the case where the medical implant 10 is the medical embolism, the medical implant 10 may further include a connecting ring (not shown in the figure), and the connecting ring is at least sleeved on the outer peripheral surface of the ends of all the liquid guiding filaments 110 provided with the liquid injection ports to fix the ends of all the liquid guiding filaments 110 provided with the liquid injection ports together. The connecting ring is, for example, a radiopaque ring.

[0062] To enhance the connection effectiveness between the push rod 20 and the medical implant 10, the medical system further includes a conductive wire 40. The conductive wire 40 can be at least partially inserted into the liquid injection channel 21, and the proximal end of the conductive wire 40 is connected to the push rod 20 by bonding, welding or any other suitable means, and the distal end of the conductive wire 40 is connected to the proximal end of the medical implant 10 by bonding, welding or any other suitable means. That is, the push rod 20 and the medical implant 10 are also indirectly connected through the conductive wire 40. An electrolytic detachment point 41 is further formed on the conductive wire 40, and the electrolytic detachment point 41 is located at the proximal end of the connection point between the conductive wire 40 and the medical implant 10. Thus, after the medical implant 10 is implanted at the target position and the film 30 is formed on the medical implant 10, the operator can disconnect the conductive wire 40 from the medical implant 10 by electrolytic detachment, and then pull the push rod 20 to make the push rod 20 separate from the liquid guiding filaments 110, and the push rod 20 and the conductive wire 40 thereon can be withdrawn from the body.

[0063] It can be understood that the push rod 20 used in the embodiments of the present invention can be a hollow push rod existing in the prior art, and the hollow chamber therein is used as the liquid injection channel 21.

[0064] In addition, the medical system may include the liquid embolism. Optionally, the liquid embolism includes but is not limited to at least one of polyvinyl alcohol, ethylene-vinyl alcohol copolymer, and n-butyl α-cyanoacrylate. It should be understood that the liquid embolism should be dissolved in the solvent, and then injected into the body together with the solvent to form the film 30. The solvent is, for example, ethanol.

[0065] Next, the working mode of the medical system will be introduced.

[0066] For the case where the medical implant 10 is the medical embolism, the process of performing a neurointerventional operation using the medical system is generally as follows:

[0067] First, a microcatheter is introduced to establish a passage that can reach the neck opening of the aneurysm. Then, the medical embolism is completely released into the aneurysm cavity and covers the neck opening by using the push rod 20 and the microcatheter in a conventional method. Next, the liquid embolizing agent is injected into the liquid guiding cavity 111 and ejected from the ejection hole 112, and solidifies to form a filamentous substance, and the filamentous substance adheres to at least the target area to form the film 30. Subsequently, electrolytic detachment of the conductive wire 40 is performed. After that, the push rod 20 is pulled in the direction from the distal end to the proximal end, so that the proximal end of the medical embolism is separated from the push rod 20. Finally, the push rod 20 and the microcatheter are withdrawn.

[0068] During the operation, the operator can determine the moment to stop injecting the liquid embolizing agent according to the angiography situation. It can be understood that the more the liquid embolizing agent is injected, the thicker the formed film 30 will be.

[0069] For the case where the medical implant 10 is the medical stent, the process of performing a neurointerventional operation using the medical system is generally as follows:

[0070] First, a microcatheter is introduced to establish a passage that can reach the neck opening of the aneurysm. Then, the medical stent is delivered to the parent artery containing the aneurysm by using the push rod 20 and the microcatheter in a conventional method, and reaches the neck opening, and the auxiliary segment 12 and the main segment 11 at the distal end of the medical stent are deployed to cover the neck opening. It can be understood that at this time, the proximal end of the medical stent is still connected to the push rod 20, so that the auxiliary segment 12 at the proximal end of the medical stent is not fully deployed. Next, the liquid embolizing agent is injected into the liquid guiding cavity 111 and ejected from the ejection hole 112, and solidifies to form a filamentous substance, and the filamentous substance adheres to at least the target area to form the film 30. Subsequently, electrolytic detachment of the conductive wire 40 is performed. After that, the push rod 20 is pulled in the direction from the distal end to the proximal end, so that the proximal end of the medical stent is separated from the push rod 20, and the auxiliary segment 12 at the proximal end of the medical stent is fully deployed. Finally, the push rod 20 and the microcatheter are withdrawn.

[0071] In summary, when the medical implant and medical system provided by the embodiments of the present invention are applied to the treatment of aneurysms, they can provide a basic framework for liquid embolization agents and serve as a carrier matrix for the membrane. Furthermore, they can understand the membrane abdominal aneurysm neck opening to effectively reduce the impact of blood on the tumor body and promote the formation of embolization in the tumor cavity. Moreover, the medical implant has a relatively low hardness during delivery, causes low damage to blood vessels, and is more easily pushed into the tumor cavity.

[0072] Although the present invention is disclosed as above, it is not limited thereto. Those skilled in the art can make various modifications and variations to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and its equivalent technologies, the present invention also intends to include these modifications and variations.

Claims

1. A medical implant, characterized in that, The invention comprises a grid-like structure woven from a plurality of wires, and at least some of the wires are liquid-conducting wires; a liquid injection port is formed on the end surface of at least one end of the liquid-conducting wire, and the liquid injection port is located at the proximal end of the grid-like structure; the liquid-conducting wire also has a liquid-conducting cavity extending along its axial direction, and the liquid-conducting cavity is connected to the liquid injection port; and a spray hole connected to the liquid-conducting cavity is opened on the side wall of the liquid-conducting wire.

2. The medical implant according to claim 1, characterized in that, The number of the liquid-conducting filaments is not less than 1 / 2 of the number of the filaments.

3. The medical implant according to claim 2, characterized in that, The number of the wires is 24 to 48.

4. The medical implant according to claim 1, characterized in that, A plurality of ejection hole groups are arranged on the side wall of the liquid-conducting wire, and the plurality of ejection hole groups are arranged at intervals along the circumference of the liquid-conducting wire; each ejection hole group includes a plurality of ejection holes, and all the ejection holes of the same ejection hole group are arranged at intervals along the axial direction of the liquid-conducting wire.

5. The medical implant according to claim 1 or 4, characterized in that, The medical implant comprises a target area, and the target area is used to cover the aneurysm neck; the ejection hole is at least arranged in the portion of the liquid-conducting wire material located in the target area.

6. The medical implant according to claim 1, wherein, The outer diameter of the wire is 0.05 mm to 0.1 mm; the inner diameter of the liquid-conducting wire is 0.04 mm to 0.08 mm; and the aperture of the ejection hole is 0.01 mm to 0.02 mm.

7. The medical implant according to claim 1, characterized in that, The medical implant is a medical embolization material or a medical stent.

8. A medical system, characterized in that, The medical implant comprises a push rod and the medical implant as claimed in any one of claims 1 to 7, wherein the distal end of the push rod is connected to the proximal end of the medical implant, and the push rod is provided with an injection channel extending through the axial direction thereof, and the injection channel is connected to the liquid conducting cavities of all the liquid conducting wires through the injection ports of all the liquid conducting wires.

9. The medical system according to claim 8, characterized in that, The ends of all the liquid-conducting wires provided with the liquid injection ports are gathered and embedded in the distal end of the liquid injection channel.

10. The medical system according to claim 8, characterized in that, The medical implant also includes a liquid embolic agent, which is used to enter the liquid guiding cavity through the injection channel and the injection port and be sprayed out from the spray hole. The sprayed liquid embolic agent solidifies to form a filament, and the filament adheres to at least a portion of the surface of the medical implant to form a coating.

11. The medical system according to claim 10, characterized in that, The liquid embolic agent comprises at least one of polyvinyl alcohol, ethylene-vinyl alcohol copolymer, and α-butyl cyanoacrylate.

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