Anti-hair loss and hair densification essence

Abstract

The invention relates to an anti-hair loss and dense hair essence which comprises the following raw materials in percentage by weight: 76.95% of water, 8% of a hair conditioner, 0.5% of an antioxidant, 6.5% of a humectant and 0.5% of an anti-hair loss agent, the hair conditioner is prepared from water, butanediol, PPG-26-butanol polyether-26, PEG-40 hydrogenated castor oil, tetrahydromethylpyrimidine carboxylic acid, caprylyl glycol, a ginseng root extract, copper tripeptide-1 and palmitoyl tetrapeptide-7, the hair loss preventing agent is a cacumen biotae extract, the antioxidant is p-hydroxyacetophenone, compared with the prior art, the hair conditioner has the effects of moisturizing and moistening, and the hair conditioner has the advantages that the anti-hair loss agent is a cacumen biotae extract, and the antioxidant is p-hydroxyacetophenone; the hair conditioner can help the hair to maintain moisture, prevent the hair from being dry and broken, and also can play a role in adjusting the viscosity of the product.

Description

Technical Field

[0001] The present invention belongs to the technical field of hair care, and specifically relates to an anti - hair - loss and hair - thickening essence. Background Art

[0002] Currently, hair loss is a relatively common problem. According to relevant research surveys, a considerable proportion of the global population is troubled by hair loss problems. In China, the number of people suffering from hair loss is also relatively large and shows an increasing trend year by year. Data shows that the number of people with hair loss in China has exceeded 200 million. Among them, the number of men with hair loss is more than that of women, but the incidence of hair loss in women is also gradually increasing.

[0003] Hair loss not only affects an individual's appearance, but may also bring psychological pressure and social barriers to patients. Many hair - loss patients will experience negative emotions such as inferiority, anxiety, and depression, which affect their quality of life and work efficiency. Therefore, there is an urgent need for a hair - care essence that can promote hair growth and reduce hair loss. Summary of the Invention

[0004] The purpose of the present invention is to provide a hair - thickening essence that can improve hair texture, promote the healthy growth of hair, and reduce hair loss.

[0005] To achieve the above - mentioned purpose, the technical solution adopted by the present invention is an anti - hair - loss and hair - thickening essence, which includes water with a raw material content ratio of 76.95%, a hair conditioner of 8%, an antioxidant of 0.5%, a humectant of 6.5%, and an anti - hair - loss agent of 0.5%. The hair conditioner consists of water, butylene glycol, PPG - 26 - buteth - 26, PEG - 40 hydrogenated castor oil, ectoine, octanediol, ginseng root extract, copper tripeptide - 1, and palmitoyl tetrapeptide - 7. The anti - hair - loss agent is extract of Platycladus orientalis, and the antioxidant is p - hydroxyacetophenone.

[0006] Furthermore, it also includes a thickener and a pH regulator, and the thickener and the pH regulator are carbomer of 0.15% and triethanolamine of 0.15% respectively.

[0007] Furthermore, the humectant includes 5% of butylene glycol, 0.5% of 1,2 - hexanediol, 0.05% of hydrolyzed sodium hyaluronate, and 0.05% of hydrolyzed collagen.

[0008] Furthermore, the hair conditioner also includes 0.05% of hydrolyzed elastin.

[0009] A preparation method of the anti - hair - loss and hair - thickening essence as described in any one of claims 1 to 4 includes the following steps:

[0010] S1, Preparation of the aqueous phase: Add the formulated amount of deionized water, humectant, and hair conditioner into a reaction kettle, and start the stirrer for stirring;

[0011] S2. Add antioxidants and anti - hair - loss agents: When the temperature of the aqueous phase drops below 40 °C, add antioxidants and stir to fully mix the antioxidants.

[0012] S3. Thickening treatment: Slowly add thickeners, continuously stir and observe the viscosity change of the system. The stirring time is 30 - 40 minutes.

[0013] S4. Adjust the pH value: Use a pH regulator to adjust the pH value of the hair conditioner to between 5.5 - 7.0. During the adjustment process, continuously stir and monitor with a pH meter to ensure the accuracy of the pH value.

[0014] A preparation method of a hair conditioner for an anti - hair - loss and hair - thinning essence according to any one of claims 1 to 5, comprising the following steps:

[0015] S1, Preparation of the aqueous phase: Add an appropriate amount of deionized water to the reaction kettle, turn on the stirrer, stir at a speed of 200 - 300 r / min, slowly add butylene glycol, and continue to stir for 10 - 15 minutes to completely dissolve butylene glycol in water.

[0016] S2, Preparation of the oil phase: In another container, mix PPG - 26 - buteth - 26 and PEG - 40 hydrogenated castor oil, heat to 50 - 60 °C, and stir evenly to fully mix the two.

[0017] S3, Emulsification: Slowly add the oil phase to the aqueous phase, while increasing the stirring speed to 400 - 500 r / min, and stir for 20 - 30 minutes to emulsify the oil phase and the aqueous phase.

[0018] S4, Add active ingredients: Lower the temperature in the reaction kettle below 40 °C, and sequentially add ectoine, caprylyl glycol, ginseng root extract, copper tripeptide - 1, and palmitoyl tetrapeptide - 7. After adding each ingredient, stir for 5 - 10 minutes to ensure that the ingredients are evenly dispersed in the conditioner.

[0019] S5, Adjust the pH value: Use a pH regulator to adjust the pH value of the hair conditioner to between 5.5 - 7.0. During the adjustment process, continuously stir and monitor with a pH meter to ensure the accuracy of the pH value.

[0020] Furthermore, after the emulsification step is completed, use a homogenizer for homogenization treatment. The homogenization pressure is controlled at 20 - 30 MPa, and the homogenization time is 5 - 10 minutes to ensure the stability and uniformity of the emulsion.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: It has the effects of moisturizing and nourishing, can help the hair retain moisture, prevent the hair from drying and breaking, and at the same time can also play a role in adjusting the viscosity of the product. PPG-26-buteth-26 has good emulsifying and dispersing properties, which can evenly distribute components such as oils in the conditioner on the hair, increasing the luster and softness of the hair. PEG-40 hydrogenated castor oil can better dissolve oil-soluble components in water, helping the conditioner to be evenly applied and spread on the hair, and at the same time can also improve the combability of the hair. Ginseng root extract is rich in various active ingredients such as ginsenosides, which has the effects of nourishing the scalp and promoting scalp blood circulation, helping to improve the hair growth environment, enhancing the toughness of the hair, reducing hair loss and breakage, and making the hair healthier and stronger. Detailed implementation mode

[0022] The technical solutions in the embodiments of the present invention are clearly and completely described below. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments.

[0023] This application is an anti-hair loss and hair thickening essence, which includes water with a raw material content ratio of 76.95%, hair conditioner 8%, antioxidant 0.5%, moisturizer 6.5% and anti-hair loss agent 0.5%, a thickener and a pH regulator. The thickener and the pH regulator are carbomer 0.15% and triethanolamine 0.15% respectively; the hair conditioner is composed of water, butylene glycol, PPG-26-buteth-26, PEG-40 hydrogenated castor oil, ectoine, octanediol, ginseng root extract, copper tripeptide-1, palmitoyl tetrapeptide-7, the anti-hair loss agent is Platycladus orientalis leaf extract, and the antioxidant is p-hydroxyacetophenone.

[0024] The moisturizer therein includes 5% butylene glycol, 0.5% 1,2-hexanediol, 0.05% hydrolyzed sodium hyaluronate and 0.05% hydrolyzed collagen.

[0025] When making the above anti-hair loss and hair thickening essence, the following steps are adopted:

[0026] S1, Preparation of aqueous phase: Add the formulated amount of deionized water, moisturizer and hair conditioner into the reaction kettle, and start the stirrer to stir;

[0027] S2. Adding antioxidant and anti-hair loss agent: When the temperature of the aqueous phase drops below 40 °C, add the antioxidant and stir to fully mix the antioxidant.

[0028] S3, Thickening treatment: Slowly add the thickener, continuously stir and observe the viscosity change of the system, and the stirring time is 30-40 minutes;

[0029] S4. Adjust the pH value: Use a pH regulator to adjust the pH value of the hair conditioner to between 5.5 and 7.0. During the adjustment process, continuously stir and monitor with a pH meter to ensure the accuracy of the pH value.

[0030] The above hair conditioner also contains 0.05% hydrolyzed elastin.

[0031] The hair conditioner of the present invention has the effects of moisturizing and nourishing, can help the hair retain moisture, prevent the hair from drying and breaking, and at the same time can also play a role in adjusting the viscosity of the product. It has good emulsifying and dispersing properties, can evenly distribute components such as oils in the conditioner on the hair, increase the gloss and softness of the hair, can better dissolve oil-soluble components in water, contribute to the uniform application and spreading of the conditioner on the hair, and at the same time can improve the combability of the hair. It has excellent moisturizing performance, can form a moisturizing film on the hair surface, prevent the loss of hair moisture, improve the elasticity and gloss of the hair, has the dual functions of moisturizing and anti-corrosion, can help maintain the moisture of the hair, while inhibiting the growth of microorganisms, extending the shelf life of the product, is rich in various active ingredients such as ginsenosides, has the effect of nourishing the scalp and promoting scalp blood circulation, helps to improve the hair growth environment, enhance the toughness of the hair, reduce hair loss and breakage, make the hair healthier and stronger, can promote the production of collagen and elastin, help repair damaged hair fibers, enhance the elasticity and toughness of the hair, improve the texture and appearance of the hair, can inhibit the inflammatory response, soothe the scalp, reduce problems such as scalp sensitivity and itching, and at the same time can promote hair growth, improve the density and quality of the hair, making the hair conditioner have multiple effects such as moisturizing, nourishing, repairing, and soothing, can improve the appearance and texture of the hair, and promote the healthy growth of the hair.

[0032] Conduct a human trial of the anti-hair loss cosmetics of this application:

[0033] I. Materials and methods

[0034] 1. Test substance: The original product of the final cosmetic product.

[0035] 2. Subjects: A total of 30 people, 11 males and 19 females, aged 26 to 57 years old, with an average age of 43.80 ± 9.42 years old, meeting the volunteer selection criteria for subjects.

[0036] 3. Test method: Let the subjects directly use the test product according to the usage characteristics and methods indicated on the cosmetic product label. Observe or follow up with the subjects by phone once a week for skin reactions, and record the results according to the grading standard of skin adverse reactions in the "Cosmetics Safety and Technical Specifications" (2015 version). The test time is not less than 4 weeks.

[0037] II. Test results

[0038] Results of Human Trial of Anti-Hair Loss Cosmetics

[0039]

[0040] Note: The skin reaction conditions of 30 subjects at different observation times are shown in the attachment.

[0041] The results of the human trial showed that 0 out of 30 people had skin adverse reactions.

[0042] Skin Reaction Conditions of 30 Subjects at Different Observation Times

[0043]

[0044]

[0045] Note: The results of the first 30 valid subjects were statistically analyzed using the systematic sampling method.

[0046] Appendix 1: Test Results of the Test Product Group and the Control Product Group (Table of Measurement Data Results)

[0047]

[0048]

[0049]

[0050] Continued Appendix 1: Test Results of the Test Product Group and the Control Product Group (Table of Measurement Data Results)

[0051]

[0052]

[0053] Then, the anti-hair loss efficacy of this product was tested:

[0054] I. Materials and Methods

[0055] 1. Test product: The original product of the cosmetic final product.

[0056] 2. Control product: The corresponding test product matrix formula product without anti-hair loss efficacy ingredients, which was tested in parallel with the test product.

[0057] 3. Elution period product: The same as the control product. During the elution period, both the test group and the control group used the control product.

[0058] 4. Instrument and Equipment

[0059] 4.1 Professional digital cameras: The pixel count is not less than 15 million, and parameters such as aperture size, ISO (sensitivity), and focal length remain consistent throughout the entire test process.

[0060] 4.2 Image shooting bracket: It can fix the position of the subject's head, keep the top of the head perpendicular to the camera lens, and cooperate with the professional digital camera to take photos of all the hair with the top of the head as the center.

[0061] 4.3 Dermoscope: LED light source, wavelength 450 - 750 nm, color temperature 6500 - 8000 K, illuminance not less than 5401x, magnification ≥ 20 times, detection diameter not less than 1.0 cm or area not less than 0.8 cm 2 .

[0062] 4.4 Comb: The tooth density is moderate (tooth spacing 0.9 - 1.1 mm), the tooth length is 2.0 - 3.0 cm, the comb length is not less than 10 cm (excluding the comb handle), and the same specification and material of the comb must be used throughout the entire test process. After each use, it is disinfected according to the relevant requirements in the "Technical Specification for Disinfection in Medical Institutions" (WS-T 367 - 2012).

[0063] 5. Subjects: A total of 60 subjects completed the test effectively, aged 29 to 60 years old. Among them, there were 30 subjects in the experimental group, 1 males and 29 females, with an average age of 48.23±9.23 years old; there were 30 subjects in the control group, 3 males and 27 females, with an average age of 49.90±8.89 years old. They met the volunteer inclusion and exclusion criteria for the subjects.

[0064] 6. Test method: Conduct the test according to the specific requirements of the current effective technical specification method. Subjects who passed the initial screening need to undergo a 2-week washout period, and then be screened again after the washout period. Qualified subjects selected for the formal test are divided into an experimental group and a control group according to the stratified random method, and the test products and control products are distributed respectively. Use the products correctly according to the product instructions for 12 weeks. During the test period, the subjects are required to keep a usage diary and strictly abide by the restrictive requirements. Visit the subjects before using the product (baseline value), and at 4 weeks, 8 weeks, and 12 weeks after using the product. Conduct hair loss counting, evaluate the local hair density, visually evaluate the overall hair density, take images, and record each time. After all the visits are completed, evaluate the overall hair density of the images.

[0065] II. Test Results

[0066] Table 1 Results of hair loss counting before and after product use (mean ± standard deviation) Unit: root

[0067]

[0068] Note: The paired t-test (or the Wilcoxon signed-rank test for two related samples) was used for statistical analysis of the test product group. Compared with the baseline value before use, *P < 0.05. Table 2 Results of the difference in hair loss count before and after product use (mean ± standard deviation) Unit: root

[0069]

[0070] Note: 1. The independent samples t-test (or the Wilcoxon rank-sum test for two independent samples) was used for statistical analysis. Compared with the control product group, *P < 0.05.

[0071] 2. Difference = Test parameter after product use - Test parameter before product use.

[0072] Table 3 Results of local hair density before and after product use (mean ± standard deviation) Unit: root / cm 2

[0073]

[0074] Note: The paired t-test (or the Wilcoxon signed-rank test for two related samples) was used for statistical analysis of the test product group. Compared with the baseline value before use, *P < 0.05. Table 4 Results of the difference in local hair density before and after product use (mean ± standard deviation) Unit: root / cm 2

[0075]

[0076] Note: 1. The independent samples t-test (or the Wilcoxon rank-sum test for two independent samples) was used for statistical analysis. Compared with the control product group, *P < 0.05.

[0077] 2. Difference = Test parameter after product use - Test parameter before product use.

[0078] ____________________________________________________________________

[0079] Table 5 Results of overall hair density before and after product use [Median (Minimum, Maximum)] Unit: grade

[0080]

[0081] Note: The Wilcoxon signed-rank test for two related samples was used for statistical analysis of the test product group. Compared with the baseline value before use, *P < 0.05.

[0082] III. Test Conclusions

[0083] 1. After using the test product, the hair loss count in the test product group showed significant improvement at the 4-week follow-up time point compared with the baseline value before use (P<0.05), and there was no significant difference at the 8-week and 12-week follow-up time points compared with the baseline value before use. Moreover, the difference in hair loss count showed significant improvement compared with the control product group at the 4-week and 12-week follow-up time points (P<0.05);

[0084] 2. After using the test product, the local hair density in the test product group showed significant differences at each follow-up time point compared with the baseline value before use (P<0.05), and the difference in local hair density showed significant differences compared with the control product group at the 12-week follow-up time point (P<0.05);

[0085] 3. After using the test product, the overall hair density in the test product group showed significant differences at the 8-week and 12-week follow-up time points compared with the baseline value before use (P<0.05), and the difference in overall hair density showed significant differences compared with the control product group at the 8-week and 12-week follow-up time points (P<0.05).

[0086] In summary, under the conditions of this test, the test product has the efficacy of preventing hair loss.

[0087] Finally, the preparation of the hair conditioning agent in this application includes the following steps:

[0088] S1, Preparation of the aqueous phase: Add an appropriate amount of deionized water to the reaction kettle, turn on the stirrer, stir at a speed of 200 - 300 r / min, slowly add butylene glycol, and continue stirring for 10 - 15 minutes to completely dissolve butylene glycol in water;

[0089] S2, Preparation of the oil phase: In another container, mix PPG-26-butanol polyether-26 and PEG-40 hydrogenated castor oil, heat to 50 - 60 °C, and stir evenly to fully mix the two;

[0090] S3, Emulsification: Slowly add the oil phase to the aqueous phase, while increasing the stirring speed to 400 - 500 r / min, and stir for 20 - 30 minutes to emulsify the oil phase and the aqueous phase;

[0091] S4, Adding active ingredients: Lower the temperature in the reaction kettle below 40 °C, and sequentially add ectoine, caprylyl glycol, ginseng root extract, copper tripeptide-1, and palmitoyl tetrapeptide-7. After adding each ingredient, stir for 5 - 10 minutes to ensure that the ingredients are evenly dispersed in the conditioning agent;

[0092] S5, Adjusting the pH value: Use a pH regulator to adjust the pH value of the hair conditioning agent to between 5.5 - 7.0. During the adjustment process, continuously stir and monitor with a pH meter to ensure the accuracy of the pH value.

[0093] After completing the emulsification step, homogenization is carried out using a homogenizer. The homogenization pressure is controlled at 20 - 30 MPa, and the homogenization time is 5 - 10 minutes to ensure the stability and uniformity of the emulsion.

[0094] As described above, it is only the specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention can easily think of changes or substitutions, which should all be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. An anti - hair loss and hair - strengthening essence, characterized in that, It includes water with a raw material content ratio of 76.95%, a hair conditioner of 8%, an antioxidant of 0.5%, a humectant of 6.5% and an anti - hair - loss agent of 0.5%. The hair conditioner consists of water, butylene glycol, PPG - 26 - buteth - 26, PEG - 40 hydrogenated castor oil, ectoine, octyldecanol, ginseng root extract, copper tripeptide - 1, and palmitoyl tetrapeptide - 7. The anti - hair - loss agent is Platycladus orientalis leaf extract, and the antioxidant is 4 - hydroxyacetophenone.

2. The anti - hair loss and hair - growth essence according to claim 1, wherein: It also includes a thickener and a pH regulator, and the thickener and the pH regulator are carbomer of 0.15% and triethanolamine of 0.15% respectively.

3. The anti - hair - loss and hair - growth essence according to claim 1, characterized in that: The humectant includes 5% of butylene glycol, 0.5% of 1,2 - hexanediol, 0.05% of hydrolyzed sodium hyaluronate and 0.05% of hydrolyzed collagen.

4. The anti-hair loss and hair growth essence according to claim 1, characterized in that: The hair conditioner also includes 0.05% of hydrolyzed elastin.

5. A preparation method of the anti - hair - loss and hair - growth essence according to any one of claims 1 to 4, characterized in that, It includes the following steps: S1, Preparation of aqueous phase: Add the formulated amount of deionized water, humectant and hair conditioner into the reaction kettle, and start the stirrer to stir. S2. Adding antioxidant and anti - hair - loss agent: When the temperature of the aqueous phase drops below 40 °C, add the antioxidant and stir to make the antioxidant fully mixed. S3, Thickening treatment: Slowly add the thickener, continuously stir and observe the viscosity change of the system, and the stirring time is 30 - 40 minutes. S4. Adjusting pH value: Use the pH regulator to adjust the pH value of the hair conditioner to between 5.5 and 7.

0. During the adjustment process, continuously stir and monitor with a pH meter to ensure the accuracy of the pH value.

6. A preparation method of a hair conditioner for the anti - hair - loss and hair - growth essence according to any one of claims 1 to 5, characterized in that, It includes the following steps: S1, Preparation of aqueous phase: Add an appropriate amount of deionized water into the reaction kettle, start the stirrer, stir at a speed of 200 - 300 r / min, slowly add butylene glycol, and continue to stir for 10 - 15 minutes to completely dissolve butylene glycol in water. S2, Preparation of oil phase: In another container, mix PPG - 26 - buteth - 26 and PEG - 40 hydrogenated castor oil, heat to 50 - 60 °C, and stir evenly to make the two fully mixed. S3, Emulsification: Slowly add the oil phase into the aqueous phase, while increasing the stirring speed to 400 - 500 r / min, and stir for 20 - 30 minutes to emulsify the oil phase and the aqueous phase. S4, Adding active ingredients: Lower the temperature in the reaction kettle below 40 °C, and sequentially add ectoine, octyldecanol, ginseng root extract, copper tripeptide - 1 and palmitoyl tetrapeptide - 7. After adding each ingredient, stir for 5 - 10 minutes to ensure that the ingredients are evenly dispersed in the conditioner. S5, Adjusting pH value: Use the pH regulator to adjust the pH value of the hair conditioner to between 5.5 and 7.

0. During the adjustment process, continuously stir and monitor with a pH meter to ensure the accuracy of the pH value.

7. The preparation method of the hair conditioner of an anti - hair loss and anti - hair thinning essence according to claim 6, characterized in that, After the emulsification step is completed, use a homogenizer for homogenization treatment. The homogenization pressure is controlled at 20 - 30 MPa, and the homogenization time is 5 - 10 minutes to ensure the stability and uniformity of the emulsion.

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