Oil-soluble composition with relieving and itching relieving functions as well as preparation method and application of oil-soluble composition

Abstract

The invention belongs to the technical field of cosmetic preparation, and particularly relates to an oil-soluble composition with relieving and itching relieving functions as well as a preparation method and application of the oil-soluble composition. After the alkanet root extract, the lavender oil, the bisabolol, the ginger root extract and the tocopheryl acetate are specifically combined, the oil-soluble composition can perform multi-target itching relieving according to an itching part, namely, itching is inhibited through different signal channels, and the effects of relieving itching and relieving are fast. Therefore, by applying the oil-soluble composition provided by the invention to corresponding products, the symptoms such as red and swollen skin and pruritus can be reduced, and the oil-soluble composition takes effect quickly and is high in safety performance.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetic preparation, and particularly relates to an oil-soluble composition with soothing and antipruritic functions, and a preparation method and application thereof. Background Art

[0002] With the continuous advancement of science and technology, the living environment is also constantly improving. However, environmental pollution continues to trouble people's lives, and more and more people have skin problems, such as itching, stinging, and redness. Although there are some products on the market for relieving skin itching, they often take a long time to heal, causing inconvenience to patients.

[0003] In addition, since skin allergies and other problems are difficult to prevent before they show symptoms such as itching and redness, it also increases the difficulty of subsequent rapid treatment. Therefore, how to provide a soothing product that is fast-acting and highly safe is a problem that needs to be solved urgently in this field. Summary of the invention

[0004] The purpose of the present invention is to provide an oil-soluble composition with soothing and antipruritic functions, and a preparation method and application thereof, which has the characteristics of rapid effect and high safety performance.

[0005] The invention provides an oil-soluble composition with soothing and antipruritic functions, which comprises, by weight, 0.001-1.0 parts of lithospermum root extract, 0.02-5.0 parts of lavender oil, 0.02-1.0 parts of bisabolol, 0.001-1.0 parts of ginger root extract and 0.1-1.0 parts of tocopherol acetate.

[0006] Preferably, the composition comprises, by weight: 0.1 part of lithospermum root extract, 0.5 part of lavender oil, 0.2 part of bisabolol, 0.001-1.0 part of ginger root extract and 0.1-1.0 part of tocopherol acetate.

[0007] Preferably, the composition comprises, by weight: 0.1 part of lithospermum root extract, 0.5 part of lavender oil, 1.0 part of bisabolol, 1.0 part of ginger root extract and 1.0 part of tocopherol acetate.

[0008] The present invention provides the use of the oil-soluble composition described in the above technical solution in the preparation of a product for reducing redness and swelling and / or relieving itching.

[0009] The present invention provides a cosmetic, comprising: the oil-soluble composition described in the above technical solution.

[0010] The present invention provides an oily agent with soothing and antipruritic functions, wherein the oily agent comprises the following components in percentage by mass:

[0011] 5%-15% hydrogenated palm kernel oil, 5%-15% cocoa seed butter, 5%-20% C12-15 alkyl benzoate, 5%-15% sunflower seed wax, 5%-15% castor oil, 0.5%-5% methyl glucoside sesquistearate, 10%-20% synthetic wax, 0.2%-15% of the oil-soluble composition described in the above technical solution, and the balance rapeseed oil with low erucic acid content.

[0012] Preferably, the synthetic wax includes one or more of microcrystalline wax, synthetic beeswax and polyethylene wax.

[0013] The present invention provides a preparation method of the oil agent described in the above technical solution, including the following steps:

[0014] Mix and stir the hydrogenated palm kernel oil, cocoa seed butter, C12-15 alkyl benzoate, sunflower seed wax, castor oil, methyl glucoside sesquistearate, synthetic wax, the oil-soluble composition described in the above technical solution, and the balance rapeseed oil with low erucic acid content.

[0015] Preferably, the temperature of the mixing and stirring is 85-120°C.

[0016] Beneficial effects:

[0017] The present invention provides an oil-soluble composition with a soothing and antipruritic function. By mass, it includes: 0.001-1.0 part of purple gromwell root extract, 0.02-5.0 parts of lavender oil, 0.02-1.0 part of bisabolol, 0.001-1.0 part of ginger root extract, and 0.1-1.0 part of tocopheryl acetate. After specifically combining purple gromwell root extract, lavender oil, bisabolol, ginger root extract and tocopheryl acetate, the oil-soluble composition can relieve itching at multiple targets according to the itchy part, that is, inhibit the occurrence of itching through different signal pathways, and has a fast effect of relieving itching and soothing.

[0018] Based on the above technical advantages, the present invention also provides the application of the oil-soluble composition described in the above technical solution in the preparation of products for reducing swelling and / or relieving itching. By applying the oil-soluble composition provided by the present invention to corresponding products, it can reduce symptoms such as skin swelling and itching, with a fast effect and high safety performance. Detailed implementation manners

[0019] In the present invention, unless otherwise specified, the reagents and equipment used are all conventional selections.

[0020] The synthetic wax preferably includes one or more of microcrystalline wax, synthetic beeswax and polyethylene wax; when the synthetic wax preferably includes multiple raw materials of microcrystalline wax, synthetic beeswax and polyethylene wax, there are no special requirements for the addition ratios of the respective raw materials, as long as the total amount meets the requirements.

[0021] To further illustrate the present invention, the solutions provided by the present invention will be described in detail below in conjunction with embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0022] Example 1

[0023] An oil-soluble composition with a soothing and antipruritic function, by mass fraction, includes:

[0024] 0.1 part of Lithospermum erythrorhizon extract;

[0025] 0.5 part of lavender oil;

[0026] 0.2 part of bisabolol;

[0027] 1.0 part of ginger root extract;

[0028] and 1.0 part of tocopheryl acetate;

[0029] Mix the above raw materials evenly to prepare an oil-soluble composition.

[0030] Example 2

[0031] An oil-soluble composition with a soothing and antipruritic function, by mass fraction, includes: 0.1 part of Lithospermum erythrorhizon extract;

[0032] 0.5 part of lavender oil;

[0033] 1 part of bisabolol;

[0034] 1.0 part of ginger root extract;

[0035] and 1.0 part of tocopheryl acetate;

[0036] Mix the above raw materials evenly to prepare an oil-soluble composition.

[0037] Example 3

[0038] An oil-soluble composition with a soothing and antipruritic function, by mass fraction, includes: 0.5 part of Lithospermum erythrorhizon extract;

[0039] 4.5 parts of lavender oil;

[0040] 0.2 part of bisabolol;

[0041] 0.5 part of ginger root extract;

[0042] and 0.5 part of tocopheryl acetate;

[0043] Mix the above raw materials evenly to prepare an oil-soluble composition.

[0044] Comparative Example 1

[0045] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight: 2 parts of lithospermum root extract;

[0046] 4.5 parts of lavender oil;

[0047] 0.2 parts of bisabolol;

[0048] 0.5 parts of ginger root extract;

[0049] and tocopherol acetate 0.5 parts;

[0050] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0051] Comparative Example 2

[0052] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight: 0.5 parts of lithospermum root extract;

[0053] 10 parts lavender oil;

[0054] 0.2 parts of bisabolol;

[0055] Ginger root extract 0.5 parts

[0056] and tocopherol acetate 0.5 parts;

[0057] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0058] Comparative Example 3

[0059] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight: 0.5 parts of lithospermum root extract;

[0060] 4.5 parts of lavender oil;

[0061] 2 parts of bisabolol;

[0062] 0.5 parts of ginger root extract;

[0063] and tocopherol acetate 0.5 parts;

[0064] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0065] Comparative Example 4

[0066] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight: 4.5 parts of lavender oil;

[0067] 0.2 parts of bisabolol;

[0068] 0.5 parts of ginger root extract;

[0069] and tocopherol acetate 0.5 parts;

[0070] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0071] Comparative Example 5

[0072] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight: 5 parts of lithospermum root extract;

[0073] 4.5 parts of lavender oil;

[0074] 0.2 parts of bisabolol;

[0075] 0.5 parts of ginger root extract;

[0076] and tocopherol acetate 0.5 parts;

[0077] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0078] Comparative Example 6

[0079] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight: 0.5 parts of lithospermum root extract;

[0080] 0.2 parts of bisabolol;

[0081] 0.5 parts of ginger root extract;

[0082] and tocopherol acetate 0.5 parts;

[0083] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0084] Comparative Example 7

[0085] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight:

[0086] 0.5 parts of Lithospermum officinale root extract;

[0087] 4.5 parts of lavender oil;

[0088] 0.5 parts of ginger root extract;

[0089] and tocopherol acetate 0.5 parts;

[0090] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0091] Comparative Example 8

[0092] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight:

[0093] 0.5 parts of Lithospermum officinale root extract;

[0094] 4.5 parts of lavender oil;

[0095] 0.2 parts of bisabolol;

[0096] and ginger root extract 0.5 parts;

[0097] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0098] Comparative Example 9

[0099] An oil-soluble composition with soothing and antipruritic functions, comprising, by weight:

[0100] 0.5 parts of Lithospermum officinale root extract;

[0101] 4.5 parts of lavender oil;

[0102] 0.2 parts of bisabolol;

[0103] and tocopherol acetate 0.5 parts;

[0104] The above raw materials are mixed evenly to prepare an oil-soluble composition.

[0105] Application Example 1

[0106] The oil-soluble compositions prepared in Examples 1-3 and Comparative Examples 1-9 were taken as test samples;

[0107] 130 mice with basically the same growth conditions were selected and divided into 13 groups, with 10 mice in each group; the mice treated with the test sample were the experimental group, and the mice treated with clean water were the control group;

[0108] The hair on the back of each group of mice was cut with scissors, and then depilatory cream was used to remove the hair to expose the skin. Sandpaper was used to rub the depilatory area of ​​the mice to make it red but not bleeding. The wound surface was 2 cm × 2 cm. 0.05 mL of 0.05% histamine phosphate solution was dripped on the wound surface every 5 minutes until the mice scratched their heads with their front paws, their trunks with their hind paws, and bit all parts of their bodies with their mouths. The itching stopped, indicating that the model was successfully established.

[0109] Drugs were administered to the wounds of mice with successful modeling, i.e., different test samples were applied to the wounds at a dosage of 1g / kg, and the control group was applied with the same mass of clean water, and the drugs were administered twice a day; after the first administration, the number of mice that stopped scratching the head with their front paws, scratching the trunk with their hind paws, biting various parts of the body with their mouths, etc. was counted every 2 hours, and the time when the last mouse in the group stopped scratching was recorded. The results are shown in Table 1; after continuous administration for 3 days and 2 days of discontinuation, the cure rate was checked based on the adverse reactions of no redness, swelling, and itching on the wounds. The results are shown in Table 1.

[0110] Table 1 Cure rate of mice in different treatments

[0111] Treatment Number of cured animals Cure rate (%) Time to stop scratching (h) Example 1 10 100 24h Example 2 9 90 22h Example 3 9 90 24h Control 1 5 50 72h Control 2 6 60 70h Control 3 5 50 74h Control 4 4 40 68h Control 5 4 40 50h Control 6 5 50 66h Control 7 4 40 52h Control 8 3 30 56h Control 9 6 60 50h Blank control 0 0 Did not stop

[0112] As can be seen from the data in Table 1, the oil-soluble composition prepared by the technical solution of the present invention has a significant antipruritic effect. After 3 days of medication, the antipruritic rate reaches up to 100%, and the pruritus symptoms all end at the latest after 24 hours. For the oil-soluble composition prepared in the comparative example, the cure rate only remains at about 50%, and the time for the pruritus to stop is longer. It can be seen that the soothing antipruritic oil-soluble composition provided by this application not only has a high cure rate but also has a quick effect.

[0113] Application Example 2

[0114] According to the results of Application Example 1, the oil-soluble composition prepared in Example 1 was selected to prepare an oil agent, and the verification was carried out. The process is as follows:

[0115] Test Group 1: The oil agent comprises the following components in mass percentage:

[0116] Hydrogenated palm kernel oil: 5%;

[0117] Cocoa seed butter: 5%;

[0118] C12-15 alkyl benzoate: 5%;

[0119] Microcrystalline wax: 5%;

[0120] Sunflower seed wax: 5%;

[0121] Castor oil: 5%;

[0122] Synthetic beeswax: 5%;

[0123] Methyl glucoside sesquistearate: 0.5%;

[0124] The oil-soluble composition prepared in Example 1: 0.2%; and the balance is low-erucic rapeseed oil. The above raw materials were stirred evenly under the condition of 100 °C.

[0125] Test Group 2: The oil agent comprises the following components in mass percentage:

[0126] Hydrogenated palm kernel oil: 8%;

[0127] Cocoa seed butter: 5%;

[0128] C12-15 alkyl benzoate: 5%;

[0129] Polyethylene wax: 10%;

[0130] Sunflower seed wax: 5%;

[0131] Castor oil: 5%;

[0132] Methyl glucoside sesquistearate: 0.5%;

[0133] The oil-soluble composition prepared in Example 1: 5%; and the balance is low erucic acid rapeseed oil. The above raw materials are stirred evenly under the condition of 100 °C.

[0134] Test Group 3: The oil agent comprises the following components in mass percentage:

[0135] Hydrogenated palm kernel oil: 5%;

[0136] Cocoa seed butter: 5%;

[0137] C12-15 alkyl benzoate: 5%;

[0138] Microcrystalline wax: 5%;

[0139] Polyethylene wax: 1%;

[0140] Sunflower seed wax: 5%;

[0141] Castor oil: 5%;

[0142] Synthetic beeswax: 5%;

[0143] Methyl glucoside sesquistearate: 0.5%;

[0144] The oil-soluble composition prepared in Example 1: 15%; and the balance is low erucic acid rapeseed oil. The above raw materials are stirred evenly under the condition of 100 °C.

[0145] Test Group 4: The oil agent comprises the following components in mass percentage:

[0146] Hydrogenated palm kernel oil: 5%;

[0147] Cocoa seed butter: 5%;

[0148] C12-15 alkyl benzoate: 5%;

[0149] Microcrystalline wax: 5%;

[0150] Sunflower seed wax: 5%;

[0151] Castor oil: 5%;

[0152] Synthetic beeswax: 5%;

[0153] Methyl glucoside sesquistearate: 0.5%;

[0154] The oil-soluble composition prepared in Example 1: 20%; and the balance is low erucic acid rapeseed oil. The above raw materials are stirred evenly under the condition of 100 °C.

[0155] Test Group 5: The oil agent comprises the following components in mass percentage:

[0156] Hydrogenated palm kernel oil: 5%;

[0157] Cocoa seed butter: 5%;

[0158] C12 - 15 alkyl benzoate: 5%;

[0159] Sunflower seed wax: 5%;

[0160] Castor oil: 5%;

[0161] Synthetic beeswax: 11%;

[0162] Methyl glucoside sesquistearate: 0.5%;

[0163] The oil-soluble composition prepared in Example 1: 0.1%; and the balance is low erucic acid rapeseed oil. The above raw materials are stirred evenly under the condition of 100°C.

[0164] Test group 6: The oil agent comprises the following components in mass percentage:

[0165] Hydrogenated palm kernel oil: 5%;

[0166] Cocoa seed butter: 5%;

[0167] C12 - 15 alkyl benzoate: 5%;

[0168] Microcrystalline wax: 5%;

[0169] Sunflower seed wax: 5%;

[0170] Castor oil: 5%;

[0171] Synthetic beeswax: 5%;

[0172] Methyl glucoside sesquistearate: 0.5%;

[0173] The oil-soluble composition prepared in Example 1: 0.05%; and the balance is low erucic acid rapeseed oil. The above raw materials are stirred evenly under the condition of 100°C.

[0174] Respectively take the oil agents prepared in Test groups 1 - 6 for testing: The method for constructing the itchy mouse model is the same as that in Application Example 1; 10 mice are selected in each test group, and the mice treated with clear water are used as the control group;

[0175] Drugs were administered to the wounds of mice with successful modeling, i.e., different test samples were applied to the wounds at a dosage of 1.5 g / kg, and the control group was applied with clean water of the same mass, and the drugs were administered 3 times a day; after the first administration, the number of mice that stopped scratching the head with their front paws, scratching the trunk with their hind paws, biting various parts of the body with their mouths, etc. was counted every 2 hours, and the time when the last mouse in the group stopped scratching was recorded. The results are shown in Table 2; after continuous administration for 3 days and 2 days of discontinuation, the cure rate was checked based on the adverse reactions of no redness, swelling, and itching on the wounds. The results are shown in Table 2.

[0176] Table 2 Cure rate of mice in different treatments

[0177] Treatment Number of cured animals Cure rate (%) Time to stop scratching (h) Test group 1 10 100 21h Test group 2 10 100 22h Test group 3 10 100 24h Test group 4 9 90 28h Test group 5 9 90 24h Test group 6 8 80 48h Blank control 0 0 Did not stop

[0178] It can be seen from the data in Table 2 that when the oil-soluble composition prepared by the present invention is added to different products for use, the addition ratio of the oil-soluble composition affects the use effect of the corresponding product; when the mass percentage of the oil-soluble composition in the product is 0.2%-15%, the oil-soluble composition can fully release its antipruritic effect, and its antipruritic rate can reach up to 100%; and increasing or decreasing the addition ratio of the oil-soluble composition in the corresponding product is not conducive to the soothing and antipruritic effect of the product.

[0179] In summary, the present invention specifically combines comfrey root extract, lavender oil, bisabolol, ginger root extract and tocopherol acetate, and the oil-soluble composition can perform multi-target antipruritic according to the itching site, that is, inhibit the occurrence of itching through different signal pathways, and can effectively reduce symptoms such as skin redness, swelling and itching, with rapid effect and high safety performance.

[0180] Although the above embodiment describes the present invention in detail, it is only a part of the embodiments of the present invention, not all of the embodiments. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all fall within the protection scope of the present invention.

Claims

1. An oil-soluble composition with a soothing and antipruritic function, characterized in that, By mass parts, it includes: 0.001 - 1.0 part of Lithospermum erythrorhizon extract, 0.02 - 5.0 parts of lavender oil, 0.02 - 1.0 part of bisabolol, 0.001 - 1.0 part of Zingiber officinale root extract, and 0.1 - 1.0 part of tocopheryl acetate.

2. The oil-soluble composition according to claim 1, characterized in that, By mass parts, it includes: 0.1 part of Lithospermum erythrorhizon extract, 0.5 part of lavender oil, 0.2 part of bisabolol, 0.001 - 1.0 part of Zingiber officinale root extract, and 0.1 - 1.0 part of tocopheryl acetate.

3. The oil-soluble composition according to claim 1, wherein By mass parts, it includes: 0.1 part of Lithospermum erythrorhizon extract, 0.5 part of lavender oil, 1.0 part of bisabolol, 1.0 part of Zingiber officinale root extract, and 1.0 part of tocopheryl acetate.

4. Use of the oil-soluble composition according to any one of claims 1 - 3 in the preparation of a product for reducing swelling and / or relieving itching.

5. A cosmetic, characterized in that, The cosmetic includes: the oil-soluble composition according to any one of claims 1 - 3.

6. An oil agent with a function of soothing itching and relieving itching, characterized in that, The oil agent includes the following components by mass percentage: 5% - 15% of hydrogenated palm kernel oil, 5% - 15% of cocoa seed butter, 5% - 20% of C12 - 15 alkyl benzoate, 5% - 15% of sunflower seed wax, 5% - 15% of castor oil, 0.5% - 5% of methyl glucoside sesquistearate, 10% - 20% of synthetic wax, 0.2% - 15% of the oil-soluble composition according to any one of claims 1 - 3, and the balance of low erucic acid rapeseed oil.

7. The sizing agent according to claim 6, characterized in that, The synthetic wax includes: one or more of microcrystalline wax, synthetic beeswax, and polyethylene wax.

8. The preparation method of the sizing agent according to claim 6 or 7, characterized in that, It includes the following steps: Mix and stir the hydrogenated palm kernel oil, cocoa seed butter, C12 - 15 alkyl benzoate, sunflower seed wax, castor oil, methyl glucoside sesquistearate, synthetic wax, the oil-soluble composition according to any one of claims 1 - 3, and the balance of low erucic acid rapeseed oil.

9. The preparation method according to claim 8, wherein The temperature of the mixing and stirring is 85 - 120 °C.