Dialysis concentrate solution preparation system and dynamic solution preparation control method

Abstract

A dialysis concentrate solution preparation system, comprising a main machine, a dialysis powder bag body and a matching kit, the main machine is an all-in-one machine, comprising: a plurality of independently controlled dissolving stations, each station is provided with a multi-modal dissolving device, the multi-modal dissolving device integrates three working modes of mechanical shaking mechanism, ultrasonic generator and magnetic stirrer. The dialysis powder bag body comprises: a flexible bag body, the flexible bag body adopts a foldable design, and the flexible bag body is provided with hemodialysis dry powder. Realize present preparation and present use of dialysis solution, and realize efficient and flexible solution preparation effect through the solution preparation system. A dialysis dry powder dynamic solution preparation control method is also provided.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a dialysis concentrate dispensing system and a dynamic dispensing control method. Background Art

[0002] Dialysate composition directly impacts the clinical condition and prognosis of hemodialysis patients. Individual differences exist among hemodialysis patients, especially for specialized patients. Dialysate prescriptions require continuous refinement and updating as their condition progresses to achieve physiological electrolyte and acid-base balance. Using personalized dialysis fluid prescriptions can reduce the incidence of dialysis complications. Providing dialysis fluids with varying ion concentrations reflects the quality of a hospital's dialysis treatment and is a crucial component of personalized clinical treatment. It also addresses the fluid supply requirements for home hemodialysis. The company is developing hemodialysis concentrates with personalized dialysis formulas.

[0003] At the same time, the transportation, storage and packaging costs of the concentrate under the existing model are high, and the changes in the physical and chemical properties of the electrolytes during storage and transportation will lead to a decline in dialysis quality (such as the precipitation of sodium bicarbonate crystals); there is a risk of concentrate contamination during centralized liquid supply and transportation. Existing hemodialysis products on the market are all filled in plastic barrels, and require the use of a dedicated hemodialysis machine to complete the configuration process. The containers used are all hard plastic barrels, which are easily damaged during transportation, and because the barrel body is heavy, it has a certain impact on the patient's mobility. When using dialysis powder or dialysis concentrate, the dialysis powder or concentrate still needs to be transferred to a new container and diluted with water, which causes problems such as easy contamination and inconvenience in use. The new container will also increase the cost. Summary of the Invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a dialysis concentrate dispensing system and a dynamic dispensing control method. The specific technical solutions are as follows:

[0005] The present invention provides a dialysis concentrate dispensing system, comprising a main unit, a dialysis powder bag and accessories. The main unit is an integrated machine, comprising: a plurality of independently controlled dissolution stations, each station being equipped with a multi-modal dissolution device, the multi-modal dissolution device integrating three working modes: a mechanical shaking mechanism, an ultrasonic generator and a magnetic stirrer; the dissolution station is also provided with a transmittance sensor located on the side of the dialysis powder bag; a temperature-controlled circulation pipeline with a built-in RO water heating module and a temperature sensor; a distributed control unit, which adopts a PLC and an HMI human-machine interface to work in coordination, the PLC being equipped with a dissolution mode decision algorithm, automatically selecting the best dissolution mode combination according to the powder type; a robot hand The robot arm is used to connect the temperature-controlled circulation pipeline and the dialysis powder bag to add liquid to the dialysis powder bag; the dialysis powder bag includes: a flexible bag with a foldable design, and the flexible bag contains hemodialysis dry powder; a lid for sealing the bag opening of the flexible bag, and the lid is provided with a connector for installing the dialysis powder bag on the dissolution station; the lid is provided with a liquid addition port and a pipette port for directly adding water to dissolve the dialysis dry powder, and forms an airtight connection with the docking port of the dissolution station through a self-locking quick connector; the accessories include: a dialysis machine pipette filter and a dialysis powder bag placement bucket.

[0006] Furthermore, the dissolution mode decision algorithm performs the following steps: reading the powder type code through the powder bag RFID tag, controlling the RO pure water to be heated to the corresponding temperature and then entering the dialysis powder bag body; calling the pre-stored database to match the corresponding dissolution parameter combination, including: ultrasonic power, shaking frequency, stirring speed, and automatically controlling the quantitative water volume to finally prepare a standard concentrated solution; and dynamically adjusting the parameters according to real-time solubility detection data, wherein the solubility is measured by a transmittance sensor.

[0007] Furthermore, a drug adding port is provided on the cover, and the distributed control unit controls the robot arm to perform drug adding operations.

[0008] Furthermore, the average pore size of the filter element of the dialysis machine pipette is 20 μm, which can filter particles and undissolved powder.

[0009] Furthermore, the host is also provided with an automatic alarm, which automatically monitors abnormal leakage and gives an alarm in real time.

[0010] Furthermore, the host is also provided with a timed cleaning device, which can pre-adjust the timed cleaning time and program, and perform cleaning when the system is not in use.

[0011] Furthermore, the host is also provided with a timed disinfection device, and the disinfection time and program are preset according to the use of the equipment.

[0012] The present invention also provides a dynamic liquid dispensing control method for dialysis dry powder, which is applied to the above-mentioned dialysis concentrate dispensing system, including the following steps: establishing a powder dissolution characteristic library and recording the solubility time curves of different powders; when a new powder is used for the first time, starting a learning mode: sequentially testing the dissolution efficiency of three basic modes and two combination modes, generating an optimal parameter combination and storing it in a database; during continuous production, automatically optimizing the dissolution sequence according to the current workstation load, giving priority to processing powder bags with high prescription urgency.

[0013] The technical solution of the present invention has the following advantages:

[0014] The present invention uses a flexible bag body to contain hemodialysis dry powder, and water is directly added to the bag body to prepare the liquid. The dialysis powder is dissolved and configured in the original bag, avoiding infection during the transfer of the concentrate. It solves the problem of requiring a large amount of medical plastic particles to make barrels of barreled dialysis fluid and the waste disposal of used barrels. It realizes three major application scenarios: hospital preparation and use, home dialysis, and personalized treatment; the volume of the concentrate is reduced by 20%, reducing the transportation damage rate and storage space. Furthermore, the dialysis concentrate dispensing system adopts multimodal collaborative dissolution technology: through the timing coordination of mechanical shaking (amplitude 3mm / frequency 3Hz), ultrasonic cavitation (28kHz / 200W) and magnetic stirring (300rpm), the dissolution time is shortened to 58 minutes; dynamic dispensing logic: based on the powder feature code, historical data is automatically retrieved to optimize parameters, which improves dissolution efficiency compared with the traditional fixed parameter mode; distributed liquid supply architecture: multiple independent workstations can process different prescriptions in parallel, and can also collaboratively supply high-demand scenarios, greatly improving the system throughput; the use of intelligent robotic arms to achieve the flexibility and safety of automatic liquid and drug addition, thereby improving production efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0017] Figure 1 A schematic structural diagram of a dialysis concentrate preparation system according to an embodiment of the present invention;

[0018] Figure 2 A schematic structural diagram of a multimodal dissolution device for a dissolution station provided in an embodiment of the present invention;

[0019] Figure 3A schematic diagram of the temperature control circulation pipeline structure provided by an embodiment of the present invention;

[0020] Figure 4 A schematic diagram of the cover interface structure provided by an embodiment of the present invention;

[0021] Figure 5 A schematic diagram of the supporting parts structure provided for an embodiment of the present invention.

[0022] Reference numerals:

[0023] 100. Main unit; 110. Dissolution station; 111. Multimodal dissolution device; 111a. Mechanical shaking mechanism; 111b. Ultrasonic generator; 111c. Magnetic stirrer; 120. Temperature control circulation pipeline; 121. RO water heating module; 122. Temperature sensor; 130. Distributed control unit; 131. PLC; 132. HMI human-machine interface; 140. Robotic arm; 200. Dialysis powder bag; 210. Flexible bag; 220. Lid; 221. Connector; 222. Liquid adding port; 223. Pipette port; 225. Dosing port; 240. Powder bag RFID tag; 300. Accessories; 310. Dialysis machine aspiration tube filter cartridge; 320. Dialysis powder bag placement bucket; 113. Transmittance sensor. DETAILED DESCRIPTION

[0024] To make the purpose, technical solutions, and advantages of the embodiments of this application more clear, the technical solutions in the embodiments of this application will be clearly and completely described below in conjunction with the drawings in the embodiments of this application. Obviously, the described embodiments are part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0025] The present invention relates to a dialysis concentrate dispensing system and control method thereof, aiming to achieve efficient dissolution and precise dispensing of dialysis dry powder through automated and intelligent equipment design. The technical solution of the present invention is described in detail below in conjunction with specific embodiments.

[0026] 1. System structure and functional modules

[0027] 1. Structure and Function of Host 100

[0028] Dissolution Station 110: The main unit is equipped with multiple independently controlled dissolution stations, each equipped with a multimodal dissolution device 111. The multimodal dissolution device integrates three operating modes: a mechanical shaking mechanism 111a, an ultrasonic generator 111b, and a magnetic stirrer 111c. These three modes can be used individually or in combination to meet the dissolution requirements of different powder types.

[0029] The dissolution station 110 is further provided with a light transmittance sensor 113 located on the side of the dialysis powder bag 200 .

[0030] Temperature control circulation pipeline 120: built-in RO water heating module 121 and temperature sensor 122, used to accurately control the liquid addition temperature to ensure that the powder is dissolved at the optimal temperature.

[0031] Distributed control unit 130: uses PLC 131 and HMI 132 to work together. PLC is equipped with a dissolution mode decision algorithm, which can automatically select the best dissolution mode combination according to the powder type. The PLC module 131 has a built-in memory 133, which pre-stores the dissolution parameter combinations corresponding to different dialysis powder types.

[0032] Robotic arm 140: Connects the temperature-controlled circulation line 120 to the dialysis powder bag 200, allowing for liquid addition to the bag. A pneumatic gripper 141 is located at the end of the robot arm. This gripper 141 mates with a connector 221 on the dialysis powder bag 200, connecting the water outlet of the temperature-controlled circulation line 120 to the liquid addition port 222 of the dialysis powder bag 200.

[0033] 2. Structure and Function of Dialysis Powder Bag 200

[0034] Flexible bag 210: adopts a foldable design and contains hemodialysis dry powder.

[0035] Lid 220: Used to seal the opening of the flexible bag. It features a connector 221 for attaching the dialysis powder bag to the dissolution station. The lid also features a liquid inlet 222 and a pipette port 223, which form an airtight connection to the docking port of the dissolution station via a self-locking quick connector. Furthermore, the lid features a drug inlet 225, which is controlled by a robotic arm controlled by a distributed control unit.

[0036] 3. Accessories 300

[0037] Dialysis machine pipette filter element 310: average pore size is 20μm, used to filter particles and undissolved powder.

[0038] Dialysis powder bag storage bucket 320: used for storing dialysis powder bags.

[0039] 2. Implementation of the Dissolution Pattern Decision Algorithm

[0040] The specific implementation steps of the dissolution mode decision algorithm are as follows:

[0041] 1. Powder type identification: The powder type code is read through the RFID tag 240 on the powder bag, and the RO pure water is heated to the corresponding temperature before entering the dialysis powder bag body 200.

[0042] 2. Parameter matching: Call the pre-stored database to match the corresponding dissolution parameter combination, including ultrasonic power, shaking frequency, stirring speed, etc., and automatically control the quantitative water volume to finally prepare a standard concentrated solution.

[0043] 3. Dynamic adjustment: The solubility is measured in real time by the transmittance sensor 113, and the dissolution parameters are dynamically adjusted according to the real-time data to ensure the efficiency and stability of the dissolution process.

[0044] The memory 133 of the PLC module 131 pre-stores dissolution parameter combinations corresponding to different powder types, including ultrasonic power, shaking frequency and stirring speed; the transmittance sensor 113 is connected to the PLC module 131 via a signal line, and real-time transmittance data is fed back to the HMI human-machine interface 132.

[0045] 3. Implementation of dosing operation

[0046] The drug adding port 225 on the cover 220 is controlled by the distributed control unit 130. When drug addition is required, the robot arm 140 injects the drug into the dialysis powder bag through the drug adding port according to the control instructions to complete the drug addition operation.

[0047] 4. Implementation of automatic alarm and cleaning and disinfection functions

[0048] 1. Automatic alarm: The host is equipped with an automatic alarm to monitor leakage and other abnormalities in real time and give an alarm in time when an abnormality occurs.

[0049] 2. Timed cleaning: The host is equipped with a timed cleaning device, which can be cleaned when the system is not in use according to the pre-adjusted timed cleaning time and program.

[0050] 3. Timed disinfection: The host is equipped with a timed disinfection device. According to the use of the equipment, the disinfection time and procedure are preset to ensure the cleanliness and hygiene of the equipment.

[0051] 5. Implementation of the Dynamic Dosing Control Method for Dialysis Dry Powder

[0052] The present invention also provides a method for controlling the dynamic dispensing of dialysis dry powder, and the specific implementation steps are as follows:

[0053] 1. Establishment of powder dissolution characteristic library: record the solubility time curves of different powders and establish the powder dissolution characteristic library.

[0054] 2. Learning Mode: When using a new powder for the first time, start the learning mode. It sequentially tests the dissolution efficiency of three basic modes (mechanical shaking, ultrasonic, magnetic stirring) and two combined modes, generates the optimal parameter combination, and stores it in the database.

[0055] 3. Dynamic optimization: During continuous production, the dissolution sequence is automatically optimized according to the current workstation load, giving priority to powder bags with high prescription urgency, thereby improving overall production efficiency.

[0056] This invention utilizes a multimodal dissolution device, intelligent control algorithms, and a robotic arm to achieve efficient dissolution and precise preparation of dialysis powder. The automated and intelligent system significantly improves the efficiency and quality of dialysis concentrate preparation while reducing the errors and risks associated with manual operation.

[0057] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, they indicate the presence of features, steps, tasks, devices, components and / or combinations thereof.

[0058] Of course, the above are preferred embodiments of the present invention. It should be noted that those skilled in the art can make several improvements and modifications without departing from the basic principles of the present invention, and these improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. A dialysis concentrate preparation system, comprising a host (100), a dialysis powder bag (200) and accessories (300), characterized in that: The host (100) is an all-in-one machine, comprising: A plurality of independently controlled dissolution stations (110), each station being equipped with a multimodal dissolution device (111), the multimodal dissolution device integrating three working modes: a mechanical shaking mechanism (111a), an ultrasonic generator (111b), and a magnetic stirrer (111c); the dissolution station (110) is further provided with a light transmittance sensor (113), which is located on the side of the dialysis powder bag (200); A temperature-controlled circulation pipeline (120) having a built-in RO water heating module (121) and a temperature sensor (122); A distributed control unit (130) employs a PLC (131) and an HMI (human-machine interface) (132) to work in coordination, wherein the PLC is configured with a dissolution mode decision algorithm to automatically select an optimal dissolution mode combination according to the type of powder; a robotic arm (140), the robotic arm being used to connect the temperature-controlled circulation pipeline (120) and the dialysis powder bag (200), thereby adding liquid to the dialysis powder bag (200); The dialysis powder bag (200) comprises: A flexible bag body (210), wherein the flexible bag body adopts a foldable design and contains hemodialysis dry powder; A cover (220) is provided for sealing the opening of the flexible bag, and a connector (221) is provided on the cover for mounting the dialysis powder bag on the dissolution station; the cover is provided with a liquid addition port (222) and a straw port (223) for directly adding water to dissolve the dialysis dry powder, and is airtightly connected to the docking port of the dissolution station (110) via a self-locking quick connector; The supporting component (300) includes: The dialysis machine liquid suction tube filter element (310) and the dialysis powder bag are placed in the barrel (320).

2. The dialysis concentrate preparation system according to claim 1, wherein: The dissolution mode decision algorithm performs the following steps: (i) reading the powder type code through the powder bag RFID tag (240), controlling the RO purified water to be heated to a corresponding temperature and then entering the dialysis powder bag body (200); (ii) calling a pre-stored database to match the corresponding dissolution parameter combination, including ultrasonic power, shaking frequency, and stirring speed, and automatically controlling the amount of water to prepare a standard concentrated solution; (iii) Dynamically adjusting parameters based on real-time solubility detection data, where the solubility is measured by a transmittance sensor (113).

3. The dialysis concentrate preparation system according to claim 1, wherein: The cover (220) is further provided with a drug adding port (225), and the distributed control unit (130) controls the robot arm (140) to perform a drug adding operation.

4. The dialysis concentrate preparation system according to claim 1, wherein: The average pore size of the filter element of the dialysis machine pipette is 20 μm, and it can filter particles and undissolved powder.

5. The dialysis concentrate preparation system according to claim 1, wherein: The host is also provided with an automatic alarm, which automatically detects abnormal leakage and gives an alarm in real time.

6. The dialysis concentrate preparation system according to claim 1, wherein: The host is also provided with a timing cleaning device, which can pre-adjust the timing cleaning time and program, and perform cleaning when the system is not in use.

7. The dialysis concentrate preparation system according to claim 1, wherein: The host is also provided with a timed disinfection device, and the disinfection time and program are preset according to the use of the equipment.

8. A method for controlling the dynamic dosing of dialysis dry powder, applied to the dialysis concentrate dosing system according to any one of claims 1 to 7, characterized in that: The steps include: (a) Establish a powder dissolution characteristic library and record the solubility-time curves of different powders; (b) When a new powder is used for the first time, the learning mode is activated: the dissolution efficiency of the three basic modes and the two combined modes is tested in sequence, and the optimal parameter combination is generated and stored in the database; (c) During continuous production, the dissolution sequence is automatically optimized based on the current workstation load, giving priority to powder bags with high prescription urgency.

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