Sample filtering device and filtering method

Abstract

The invention relates to a filtering device and a filtering method, in particular to a sample filtering device and a filtering method. The sample filtering device comprises a pushing and injecting assembly, a clamping plate and a filtering assembly, the pushing and injecting assembly is arranged in a containing groove of the fixing seat, the fixing seat is in sliding connection with the sliding guide rod, the two ends of the sliding guide rod are connected with the first fixing plate and the second fixing plate respectively, and the clamping plate is arranged between the first fixing plate and the fixing seat and used for being matched with the fixing seat to fix the pushing and injecting assembly. The clamping plate is in sliding connection with the sliding guide rod, the sliding guide rod is sleeved with a spring, and an adjusting mechanism is arranged on the first fixing plate and used for adjusting the clamping force of the clamping plate; one end of the filter assembly is connected with the output end of the injection assembly, and the other end is connected with the second fixing plate. The problems of sample leakage, low filtering efficiency and unstable operation caused by low coaxiality in an existing manual filtering device are solved.

Description

Technical Field

[0001] The present invention relates to a filtering device and a filtering method, and particularly to a sample filtering device and a filtering method. Background Art

[0002] In sample filtering, for example, during ion chromatography analysis, precise filtering of samples is one of the key steps to ensure the accuracy and repeatability of experimental results. However, existing sample filtering devices often face some technical challenges in practical applications. The main problem of traditional filtering devices is the low coaxiality between the injection assembly and the filtering assembly, that is, it is difficult for the two to maintain a straight alignment state during assembly and use. Especially relying on manual pushing, this low coaxiality not only causes the movement of the piston rod of the injection assembly in the cylinder to be unstable, increasing the operation difficulty, but also makes it easy for the injection assembly and the filtering assembly to be offset or tilted. This situation will cause sample leakage and a decrease in filtering efficiency, seriously affecting the quality and reliability of sample filtering.

[0003] Now, the present invention designs a sample filtering device and a filtering method to solve the above technical problems. Summary of the Invention

[0004] The present invention provides a sample filtering device and a filtering method, aiming to solve the problems of sample leakage, low filtering efficiency, and unstable operation caused by low coaxiality in existing manual filtering devices. The technical solutions are as follows: A sample filtering device includes an injection assembly, a clamping plate, and a filtering assembly; the injection assembly is arranged in the receiving groove of a fixed seat, the fixed seat is slidably connected with a sliding guide rod, both ends of the sliding guide rod are respectively connected to a first fixing plate and a second fixing plate, the clamping plate is arranged between the first fixing plate and the fixed seat and is used to cooperate with the fixed seat to fix the injection assembly, the clamping plate is slidably connected with the sliding guide rod, a spring is sleeved on the sliding guide rod, and an adjusting mechanism is arranged on the first fixing plate for adjusting the clamping force of the clamping plate; one end of the filtering assembly is connected to the output end of the injection assembly, and the other end is connected to the second fixing plate.

[0005] Based on the above technical solution, the adjusting mechanism is a screw, which is threadedly connected to the first fixing plate to adjust the distance between the clamping plate and the fixed seat, so as to clamp and loosen the injection assembly.

[0006] Based on the above technical solution, a receiving hole is formed on the fixed seat, and the receiving hole includes an arc-shaped positioning part and a linear limiting part, and the width of the linear limiting part is smaller than the diameter of the arc-shaped positioning part.

[0007] Preferably, a flank accommodation groove for accommodating the flank of the injection assembly is provided on the fixed seat, and a pressing protrusion is provided on the clamping plate, and the shape of the pressing protrusion matches the shape of the flank accommodation groove.

[0008] A sample filtering method using the filtering device as described above specifically includes the following steps: S1. Loosen the adjusting mechanism to separate the clamping plate from the fixed seat; S2. Move the fixed seat, place the injection assembly in the fixed seat, and ensure that the piston rod is not pushed into the cylinder when placing; S3. Place the filtering assembly so that its end passes through the second fixing plate, enabling the filtering assembly to be connected to an external device; S4. Align the filtering assembly and the injection assembly and insert and fix them; S5. Move the fixed seat back to clamp the injection assembly with the accommodation hole; S6. Move the clamping plate to the right so that the clamping plate and the fixed seat jointly clamp the flank of the injection assembly; S7. Operate the adjusting mechanism to tightly press the clamping plate against the injection assembly to fix it; S8. Start the power unit to drive the piston rod to push the sample into the filtering assembly to complete the injection and filtering process of the sample.

[0009] Beneficial Effects Compared with the prior art, the beneficial effects of the present invention are as follows: 1. Improve coaxiality and operation stability: Through the fixed seat and the clamping plate, high coaxiality between the injection assembly and the filtering assembly is ensured, solving the problem of difficult linear alignment in traditional manual operations. This not only improves the movement stability of the piston rod in the cylinder but also reduces the risk of sample leakage. 2. Ensure high coaxiality: The accommodation hole is designed to include an arc-shaped positioning portion and a linear limiting portion, and the width of the linear limiting portion is smaller than the diameter of the arc-shaped positioning portion, which can effectively guide and limit the position of the injection assembly to ensure high coaxiality between it and the filtering assembly. Description of the Drawings

[0010] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only one embodiment of the present invention, and for those of ordinary skill in the art, without creative efforts, other implementation drawings can be obtained by extending according to the provided drawings.

[0011] Figure 1 : Schematic structural diagram of the present invention; Figure 2 : Schematic diagram of the positions of the clamping plate and the fixed seat of the present invention; Figure 3 : Side view of the present invention; Figure 4 : Figure 3 Cross-sectional view at A-A in [it]; Figure 5 : Schematic structural view of the fixing base of the present invention; Figure 6 : Schematic structural view of the receiving hole of the present invention; Figure 7 : Schematic structural view of the clamping plate of the present invention; Figure 8 : Schematic structural view of the filter element of the present invention; Figure 9 : Schematic structural view of the injection assembly of the present invention; Figure 10 : Schematic structural view of the installation groove of the temperature control module of the present invention; Among them, 1. Injection assembly; 11. Cylinder body; 12. Piston rod; 13. Power unit; 2. First fixing plate; 3. Clamping plate; 31. Pressing protrusion; 4. Fixing base; 41. Receiving hole; 411. Arc-shaped positioning part; 412. Linear limiting part; 42. Flank receiving groove; 43. Detection installation groove; 44. Module installation groove; 5. Sliding guide rod; 6. Second fixing plate; 7. Spring; 8. Screw; 91. Filter sheet; 92. First connecting pipe; 93. Second connecting pipe. Detailed implementation manners

[0012] The present invention will be further described below in conjunction with the drawings and examples: The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the drawings, where the same or similar reference numerals indicate the same or similar elements or elements with the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are only used to explain the present invention and should not be construed as a limitation to the present invention.

[0013] In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, the terms "installation", "connection", and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection or an indirect connection through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0014] In the description of the present invention, it should be understood that the orientation or positional relationships indicated by the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. are based on the orientation or positional relationships shown in the drawings. These are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation on the present invention. Embodiment 1 As Figure 1 shown, a sample filtering device includes a pushing assembly 1, a clamping plate 3, and a filtering assembly; the pushing assembly 1 is arranged in the receiving groove of a fixed seat 4.

[0015] The receiving groove provides a positioning space for the pushing assembly 1. This ensures that each time it is installed, the pushing assembly can be in the same position, greatly improving the positioning accuracy and repeatability.

[0016] As Figure 2 shown, the fixed seat 4 is slidably connected to a sliding guide rod 5. Both ends of the sliding guide rod 5 are respectively connected to a first fixing plate 2 and a second fixing plate 6, and the number of the sliding guide rods 5 is two.

[0017] By providing two sliding guide rods 5, the stability of the fixed seat 4 during movement can be significantly improved. The double-guide-rod structure can more effectively resist lateral forces and torques, reduce the swaying or offset of the fixed seat during operation, and ensure that it maintains linear motion.

[0018] As Figure 3 and 4 shown, the clamping plate 3 is arranged between the first fixing plate 2 and the fixed seat 4 and is used to cooperate with the fixed seat 4 to fix the pushing assembly 1. The clamping plate 3 is slidably connected to the sliding guide rod 5.

[0019] The clamping plate 3 and the fixed seat 4 can be used in cooperation to firmly clamp the side wings of the pushing assembly 1, ensuring that it will not loosen or shift during operation.

[0020] Since the clamping plate 3 is slidably connected to the sliding guide rod 5, it can move freely along the direction of the sliding guide rod 5 as needed, thereby conveniently adjusting the position of the clamping plate 3 to adapt to different sizes or types of pushing assemblies 1.

[0021] A spring 7 is sleeved on the sliding guide rod 5. The spring 7 is located at one end of the sliding guide rod 5 close to the second fixing plate 6, that is, between the second fixing plate 6 and the fixed seat 4.

[0022] The spring 7 applies a continuous pre-tightening force to the fixed seat 4, which helps to maintain the stability and position accuracy of the fixed seat 4 during operation. This pre-tightening force can prevent the fixed seat 4 from making unnecessary movements due to vibration or external interference, ensuring that it always remains in the optimal working position.

[0023] One end of the filtering component is connected to the output end of the injection assembly 1, and the other end is connected to the second fixing plate 6.

[0024] An adjustment mechanism is provided on the first fixing plate 2 for adjusting the clamping force of the clamping plate 3. The adjustment mechanism is a screw 8, and the screw 8 is threadedly connected to the first fixing plate 2 to adjust the distance between the clamping plate 3 and the fixed seat 4, so as to achieve the clamping and relaxation of the injection assembly 1. The screw adjustment mechanism allows the user to make very fine adjustments. By rotating the screw 8, the position of the clamping plate 3 can be precisely controlled, so as to achieve the ideal clamping force.

[0025] After adjusting the adjustment mechanism such as the screw 8, the spring 7 can also cooperate with the adjustment mechanism to fix and clamp the fixed seat 4.

[0026] As Figure 5 and Figure 7 shown, a flank receiving groove 42 for receiving the flank of the injection assembly 1 is provided on the fixed seat 4, and a pressing protrusion 31 is provided on the clamping plate 3. The shape of the pressing protrusion 31 matches the shape of the flank receiving groove 42.

[0027] This design makes the installation of the injection assembly 1 more intuitive and simple. The user only needs to align the flank of the injection assembly and place it into the flank receiving groove 42, and then fix it through the pressing protrusion 31 on the clamping plate 3. There is no need for complex adjustment steps, which greatly simplifies the assembly process and reduces the operation time and difficulty.

[0028] As Figure 6 shown, a receiving hole 41 is formed on the fixed seat 4. The receiving hole 41 includes an arc-shaped positioning portion 411 and a linear limiting portion 412. The width of the linear limiting portion 412 is smaller than the diameter of the arc-shaped positioning portion 411.

[0029] If the receiving hole 41 adopts a U-shaped design, during the injection process, there is no restraint on one side of the U-shaped opening, which is likely to cause the injection assembly 1 to deviate or tilt in this direction, affecting the coaxiality. The existence of the linear limiting portion 412 can effectively limit this deviation. Through the restraint provided by the linear limiting portion 412, the shaking or vibration of the injection assembly during operation can be effectively reduced.

[0030] The arc-shaped positioning portion 411 and the linear limiting portion 412 work together to constrain the injection assembly 1. This ensures that the injection assembly 1 can maintain high-precision coaxiality throughout the operation, reducing problems such as sample leakage, difficult operation, and low filtration efficiency caused by misalignment.

[0031] As Figure 8 shown, the filtration assembly is a filter element, and the filter element includes a filter sheet 91. First connecting pipes 92 and second connecting pipes 93 are respectively arranged at both ends of the filter sheet 91. The first connecting pipe 92 is connected to the output end of the injection assembly 1, and the second connecting pipe 93 is used to connect to external equipment.

[0032] The filtration assembly is composed of a plurality of filter elements connected in sequence. Between adjacent two filter elements, the second connecting pipe 93 of the previous filter element is connected to the first connecting pipe 92 of the subsequent filter element.

[0033] The first connecting pipe 92 is a tapered pipe, and the diameter of the end close to the filter sheet 91 is smaller than the end far from the filter sheet 91. When the first connecting pipe 92 is inserted into the second connecting pipe 93, a tight contact surface can be formed, reducing the possibility of leakage.

[0034] Adopting a modular design allows for flexible combination of different numbers and types of filter elements according to specific requirements. For example, filter sheets 91 with different pore sizes, materials, or functions can be selected according to sample characteristics or filtration requirements, thereby realizing a customized filtration solution.

[0035] As Figure 9 shown, the injection assembly 1 includes a cylinder body 11 and a piston rod 12. The piston rod 12 is slidably arranged inside the cylinder body 11. A power unit 13 is installed on the fixed seat 4, and the output end of the power unit 13 is connected to the piston rod 12. The power unit 13 drives the piston rod 12 to perform reciprocating motion inside the cylinder body 11.

[0036] The power unit 13 can provide very precise control to ensure that the movement amount and speed of the piston rod 12 inside the cylinder body 11 can be accurately adjusted. This is particularly important for application scenarios that require strict control of the sample injection volume, such as ion chromatography analysis, etc. The power unit 13 can be a linear motor or an electric push rod. The main body of the electric push rod is connected to the fixed seat 4, and the output rod is connected to the piston rod 12, driving the electric push rod to push the piston rod 12 into the cylinder body 11.

[0037] As Figure 10 shown, a module installation groove 44 is opened at the bottom of the fixed seat 4, and a refrigeration module, a heating module, or an ultraviolet lamp is installed in the module installation groove 44.

[0038] Some chemical substances or biological samples such as enzymes, proteins, antibodies, etc. are prone to denaturation or degradation at room temperature or high temperature. Or some chemical reactions need to be carried out effectively at a specific temperature. In order to complete the sample filtration at a specific temperature, a refrigeration module or a heating module can be set in the module installation groove 44. By integrating the refrigeration module or the heating module, cooling or heating operations can be carried out according to the needs of the sample. This flexibility enables the device to adapt to experimental conditions with different temperature requirements.

[0039] A detection installation groove 43 is provided on the inner side wall of the fixed seat 4, and a temperature sensor is installed in the detection installation groove 43. The temperature sensor can monitor the temperature change inside the fixed seat in real time and feed the data back to the control system, so as to realize temperature control and ensure temperature stability and accuracy.

[0040] The fixed seat 4 is made of a heat-conducting material, and a heat-insulating cover is also provided on the fixed seat 4. The design of the heat-insulating cover reduces the influence of the external environment on the temperature inside the fixed seat 4, maintains the stability of the internal temperature, reduces energy loss, and improves the energy efficiency ratio of the system.

[0041] When dealing with pathogenic microorganisms or highly pathogenic samples, in order to ensure the effective killing of microorganisms on the experimental equipment, workbench surface and in the air, ultraviolet irradiation can be used as an additional protective measure. Specifically, an ultraviolet lamp is set in the module installation groove 44. Ultraviolet (UV) sterilization mainly depends on ultraviolet rays of a specific wavelength, which can destroy the DNA or RNA structure of microorganisms, thereby effectively killing or inactivating bacteria, viruses and other pathogens.

[0042] Embodiment 2 A sample filtration method using the above filtration device specifically includes the following steps: Release the fixation of the injection assembly 1 to prepare for subsequent installation or replacement: loosen the adjustment mechanism such as the screw 8 to separate the clamping plate 3 from the fixed seat 4; the clamping plate 3 and the fixed seat 4 can slide on the sliding guide rod 5.

[0043] Install the injection assembly 1 to ensure its smooth operation: move the fixed seat 4 along the sliding guide rod 5 to a suitable position to facilitate the installation of the injection assembly 1, insert the cylinder body 11 of the injection assembly 1 into the receiving groove of the fixed seat 4, and be careful not to push the piston rod 12 into the cylinder body 11. Confirm that the injection assembly 1 is placed firmly, and the side wings of the injection assembly 1 are aligned with the side wing receiving grooves 42 of the fixed seat 4.

[0044] Assemble the filtration assembly and install the filtration assembly: put in the filtration assembly so that its end passes through the second fixing plate 6, so that the filtration assembly can be connected to external equipment; one end of the filtration assembly, usually the second connecting pipe 93, passes through the hole on the second fixing plate 6 to ensure that it can be connected to external equipment such as a collection bottle, a detection instrument, etc.

[0045] Align the filtering component and the syringe component 1, and insert and fix them. Align the output end of the syringe component 1 with the first connecting pipe 92 of the filtering component.

[0046] Move the fixed seat 4 backward to make the receiving hole 41 tightly clamp the syringe component 1; Slowly move the fixed seat 4 backward along the sliding guide rod 5 until the receiving hole 41 catches the syringe component 1.

[0047] Move the clamping plate 3 to the right so that the clamping plate 3 and the fixed seat 4 jointly clamp the side wing of the syringe component 1. Move the clamping plate 3 to the right along the sliding guide rod 5 until its pressing protrusion 31 contacts the side wing of the syringe component 1.

[0048] Operate the adjusting mechanism to make the adjusting mechanism tightly press against the clamping plate 3 to fix the syringe component 1. Operate the adjusting mechanism such as the screw 8, and gradually increase the pressure on the clamping plate 3. Until an ideal clamping force is achieved between the clamping plate 3 and the syringe component 1 to ensure that the syringe component 1 will not be displaced or loosened during operation.

[0049] Start the power unit 13 to drive the piston rod 12 to push the sample into the filtering component to complete the injection and filtering process of the sample.

[0050] When disassembling the filtering device, operate the adjusting mechanism to loosen the clamping plate 3, and move the clamping plate 3 to the left to separate it from the fixed seat 4. Separate the filtering component from the syringe component 1 and release the fixation of the fixed seat 4 on the syringe component 1: Gently pull out the connection between the output end of the syringe component 1 and the second connecting pipe 93 of the filtering component. Remove the syringe component 1 and then remove the filtering component.

[0051] It should be noted that the syringe component, refrigeration module, heating module, temperature sensor, heat preservation cover, etc. in this embodiment are all general standard parts or components known to those skilled in the art, and their structures and principles can be known to those skilled in the art through technical manuals or obtained through conventional experimental methods.

[0052] The present invention has been described by way of example above, but the present invention is not limited to the above specific embodiments, and any modification or variation based on the present invention falls within the scope of protection required by the present invention.

Claims

1. A sample filtering device, characterized in that: It includes a syringe component (1), a clamping plate (3) and a filtering component; the syringe component (1) is arranged in the receiving groove of a fixed seat (4), the fixed seat (4) is slidably connected with a sliding guide rod (5), both ends of the sliding guide rod (5) are respectively connected to a first fixing plate (2) and a second fixing plate (6), the clamping plate (3) is arranged between the first fixing plate (2) and the fixed seat (4) and is used to cooperate with the fixed seat (4) to fix the syringe component (1), the clamping plate (3) is slidably connected with the sliding guide rod (5), a spring (7) is sleeved on the sliding guide rod (5), and an adjusting mechanism is arranged on the first fixing plate (2) for adjusting the clamping force of the clamping plate (3); one end of the filtering component is connected to the output end of the syringe component (1), and the other end is connected to the second fixing plate (6).

2. The sample filtering device according to claim 1, characterized in that: The adjusting mechanism is a screw (8), the screw (8) is threadedly connected to the first fixing plate (2) to adjust the distance between the clamping plate (3) and the fixed seat (4) so as to realize the clamping and loosening of the syringe component (1).

3. The sample filtration device according to claim 1, wherein: A receiving hole (41) is formed in the fixed seat (4), the receiving hole (41) includes an arc-shaped positioning part (411) and a linear limiting part (412), and the width of the linear limiting part (412) is smaller than the diameter of the arc-shaped positioning part (411).

4. The sample filtering device according to claim 2, characterized in that: A flank receiving groove (42) for receiving the flank of the syringe component (1) is arranged on the fixed seat (4), and a pressing protrusion (31) is arranged on the clamping plate (3), and the shape of the pressing protrusion (31) matches the shape of the flank receiving groove (42).

5. A sample filtering device according to claim 1, characterized in that: The filtering component is a filtering element, the filtering element includes a filtering sheet (91), first connecting pipes (92) and second connecting pipes (93) are respectively arranged at both ends of the filtering sheet (91), the first connecting pipe (92) is connected to the output end of the syringe component (1), and the second connecting pipe (93) is used for connecting an external device.

6. The sample filtering device according to claim 5, wherein: The filtering component is composed of a plurality of filtering elements connected in sequence, and adjacent two filtering elements are connected through the second connecting pipe (93) of the previous filtering element and the first connecting pipe (92) of the next filtering element.

7. The sample filtering device according to claim 1, characterized in that: The syringe component (1) includes a cylinder body (11) and a piston rod (12), the piston rod (12) is slidably arranged inside the cylinder body (11), a power unit (13) is installed on the fixed seat (4), the output end of the power unit (13) is connected to the piston rod (12), and the power unit (13) drives the piston rod (12) to reciprocate inside the cylinder body (11).

8. The sample filtering device according to claim 1, characterized in that: A module installation groove (44) is formed at the bottom of the fixed seat (4), a refrigeration module, a heating module or an ultraviolet lamp is installed in the module installation groove (44); a detection installation groove (43) is arranged on the inner side wall of the fixed seat (4), and a temperature sensor is installed in the detection installation groove (43).

9. The sample filtering device according to claim 8, wherein: The fixed seat (4) is made of a heat-conducting material, and a heat-insulating cover is further arranged on the fixed seat (4).

10. A sample filtering method, using the filtering device as claimed in claim 7, specifically including the following steps: characterized in that S1. Loosen the adjusting mechanism to separate the clamping plate (3) from the fixed seat (4). S2. Move the fixed seat (4), and place the injection assembly (1) into the fixed seat (4), ensuring that the piston rod (12) is not pushed into the cylinder body (11) during placement. S3. Place the filter assembly, and make its end pass through the second fixing plate (6) so that the filter assembly can be connected to external equipment. S4. Align the filter assembly and the injection assembly (1), and insert and fix them. S5. Move the fixed seat (4) back to make the receiving hole (41) clamp the injection assembly (1). S6. Move the clamping plate (3) to the right so that the clamping plate (3) and the fixed seat (4) jointly clamp the side wings of the injection assembly (1). S7. Operate the adjusting mechanism to make the adjusting mechanism tightly press against the clamping plate (3) to fix the injection assembly (1). S8. Start the power unit (13) to drive the piston rod (12) to push the sample into the filter assembly to complete the injection and filtration process of the sample.

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