A device for degradation experiments of alginate hydrogels

Abstract

This application discloses an experimental apparatus for the degradation of alginate hydrogel, belonging to the technical field of degradation testing devices. It includes, from top to bottom, an infusion device, a distributor, several sample chambers, and several body fluid recovery tanks. A first pipe connects the infusion device to the main channel of the distributor, and a check valve is installed on the first pipe. Each branch channel of the distributor corresponds to one of the sample chambers. A second pipe connects each branch channel of the distributor to its corresponding sample chamber, and a flow rate regulator is installed on the second pipe. Each sample chamber corresponds to one of the body fluid recovery tanks, and a third pipe connects each sample chamber to its corresponding body fluid recovery tank. This application improves experimental efficiency.

Description

Technical Field

[0001] This application relates to the technical field of degradation testing apparatus, and in particular to a degradation testing apparatus for alginate hydrogel. Background Technology

[0002] Alginate hydrogels are a class of natural polymeric materials with excellent biocompatibility and biodegradability, widely used in drug delivery, wound dressings, food packaging, environmental protection, and many other fields. Especially in the medical field, alginate hydrogels have become an important drug delivery system or tissue engineering material in clinical treatment due to their ability to mimic the biological tissue environment and their good biodegradability. Studying the degradation time and degradation patterns of calcium alginate gels provides fundamental data support for in vivo implantation of calcium alginate gels. By controlling the degradation rate and mode, sustained drug release, tissue engineering, and biomedical applications can be achieved. Therefore, research on the degradation of alginate hydrogels has significant scientific and practical value.

[0003] To study the degradation properties of alginate hydrogels, ultrapure sodium alginate is typically used to prepare a gel. The resulting alginate hydrogel is then placed in an in vitro simulated body fluid environment to mimic its degradation in vivo. The degradation rate is calculated based on the mass change of the alginate hydrogel. However, the flow rate of body fluids varies in different parts of the human body, requiring experimenters to control different simulated body fluid flow rates, making the experimental procedure quite cumbersome. Summary of the Invention

[0004] To address the issue of experimental operators needing to simulate the flow rate of bodily fluids in different parts of the human body for testing, this application provides an experimental apparatus for the degradation of alginate hydrogels.

[0005] The experimental apparatus for the degradation of alginate hydrogel provided in this application adopts the following technical solution:

[0006] An experimental apparatus for the degradation of alginate hydrogel includes, from top to bottom, an infusion device, a diverter, several sample chambers, and several body fluid recovery tanks. A first pipe connects the infusion device to the main channel of the diverter, and a check valve is installed on the first pipe. Each branch channel of the diverter corresponds to one of the sample chambers. A second pipe connects each branch channel of the diverter to its corresponding sample chamber, and a flow rate regulator is installed on the second pipe. Each sample chamber corresponds to one of the body fluid recovery tanks, and a third pipe connects each sample chamber to its corresponding body fluid recovery tank.

[0007] By adopting the above technical solution, alginate hydrogel is placed in the sample chamber, and simulated body fluid is placed in the infusion device. The check valve is opened, and the simulated body fluid enters the splitter through pipe one. The simulated body fluid in the splitter enters the sample chamber through the branch channel and pipe two. After flowing through the alginate hydrogel in the sample chamber, it flows into the body fluid recovery pool through pipe three. The flow rate regulator can adjust the flow rate of the simulated body fluid in different pipes two, so that the flow rate of the simulated body fluid is consistent with the flow rate of body fluid in different parts of the human body. Thus, the degradation rate of alginate hydrogel in different parts of the human body can be simulated for experimental testing. The operation is simple and the experimental efficiency is high.

[0008] Preferably, the sample chamber includes a mounting sleeve for placing samples, a pagoda connector is installed at the bottom of the mounting sleeve, the top of the pagoda connector is fixedly connected to the bottom of the mounting sleeve, and the bottom of the pagoda connector is connected to the three-way pipe.

[0009] By adopting the above technical solution, closing the stop valve, and then removing the pagoda connector, the alginate hydrogel inside the installation sleeve can be taken out and weighed. The degradation rate of the alginate hydrogel can be calculated based on the mass change of the alginate hydrogel. The operation is simple and the test cost is low.

[0010] Preferably, the device further includes a temperature control device, which includes a water tank. The inner wall of the water tank is provided with a heating wire. A limiting frame for placing the infusion device is fixed on the inner bottom surface of the water tank. Several through holes are provided on the sides of the limiting frame. A pressure plate is provided on the limiting frame. The bottom surface of the pressure plate can abut against the infusion device. Several through holes are provided on the top surface of the pressure plate. A clearance groove for placing the pipe is provided on the top surface of the limiting frame. A squeezing component for squeezing the infusion device is provided inside the limiting frame.

[0011] By adopting the above technical solution, the infusion device is placed in the limiting frame, and then the pipeline passes through the relief groove. The pressure plate abuts against the top of the infusion device, thereby limiting the infusion device. The squeezing component squeezes the infusion device, causing the simulated body fluid in the infusion device to flow downward through the pipeline. The water temperature in the water tank can be controlled by the heating wire, so that the simulated body fluid in the infusion device is kept at a constant temperature, reducing the impact of temperature changes on the test results. At the same time, it is possible to test the degradation rate of alginate hydrogel at different body fluid temperatures to understand the effect of different body fluid temperatures on the degradation rate of alginate hydrogel.

[0012] Preferably, the extrusion assembly includes an extrusion roller, and the limiting frame has grooves on opposite sides. Slider blocks are provided at both ends of the extrusion roller, and the sliders slide and engage with the limiting frame along its length via the grooves. A movable through-slot is provided on the side of the limiting frame away from the pipe, allowing the extrusion roller to move into the movable through-slot.

[0013] By adopting the above technical solution, in the initial state, the squeezing roller is located in the moving channel, the infusion device is placed in the limiting frame, the squeezing roller is located on the side of the infusion device away from the pipeline, the squeezing roller is moved towards the direction closer to the pipeline, the squeezing roller squeezes the infusion device, so that the simulated body fluid in the infusion device flows smoothly into the pipeline.

[0014] Preferably, a drive screw is rotatably mounted in one of the slides, the drive screw passes through the slider, the slider and the drive screw are threadedly engaged, a motor is fixed to the side of the limiting frame, and the output end of the motor is fixedly connected to the end of the drive screw.

[0015] By adopting the above technical solution, the motor is started, the motor drives the drive screw to rotate, the drive screw drives the slider to move, and then drives the extrusion roller to move towards the direction closer to the pipe.

[0016] Preferably, a rotating rod is fixed at each end of the extrusion roller, and the rotating rod is rotatably connected to the slider. A bevel gear one is fixedly sleeved on the outer periphery of one of the rotating rods, and a bevel gear two is sleeved on the outer periphery of the drive screw. The bevel gear two meshes with the bevel gear one. A synchronizing block is fixed on the inner circumferential surface of the bevel gear two. A synchronizing groove is formed on the outer circumferential surface of the drive screw. The synchronizing block slides and engages with the drive screw along the length direction of the drive screw through the synchronizing groove.

[0017] By adopting the above technical solution, the drive screw drives the second bevel gear to rotate through the synchronizing block and synchronizing groove. The second bevel gear drives the first bevel gear to rotate, and the first bevel gear drives the rotating rod to rotate, which in turn drives the extrusion roller to rotate.

[0018] Preferably, the top surface of the limiting frame is fixed with two fixing blocks, and a fixing rod is rotatably installed between the two fixing blocks. The pressure plate is sleeved on the outer periphery of the fixing rod, and the bottom surface of the pressure plate can abut against the top surface of the limiting frame. A torsion spring is sleeved on the outer periphery of the fixing rod, one end of the torsion spring is fixedly connected to the fixing block, and the other end of the torsion spring is fixedly connected to the pressure plate.

[0019] By adopting the above technical solution, after opening the pressure plate and placing the infusion device into the limiting frame, the pressure plate rotates downward under the elastic force of the torsion spring and abuts against the top surface of the limiting frame, while the bottom surface of the pressure plate fits against the infusion device, thereby limiting the infusion device.

[0020] Preferably, the first pipeline includes a connecting pipe 1 connected to the infusion device and a connecting pipe 2 connected to the diverter. A buffer sleeve is connected between the first connecting pipe and the second connecting pipe. A control groove is formed on the inner top surface of the buffer sleeve. A control block is vertically slidably installed on the buffer sleeve through the control groove. A movable contact piece is fixed on the side of the control block. A moving groove is formed on the inner wall of the control groove. The movable contact piece slides vertically with the buffer sleeve through the moving groove. A fixed contact piece for electrical contact with the movable contact piece is fixed on the inner bottom surface of the moving groove. The fixed contact piece is electrically connected to a power source. The movable contact piece is electrically connected to a motor. A float ring is vertically slidably installed inside the buffer sleeve. The top surface of the float ring can abut against the bottom surface of the control block.

[0021] By adopting the above technical solution, when the motor starts and the squeezing roller squeezes the infusion device, the simulated body fluid in the infusion device enters the buffer sleeve through the first connecting pipe, and then enters the diverter through the second connecting pipe. As the body fluid in the buffer sleeve gradually increases, the float ring moves upward and abuts against the control block, thereby pushing the control block upward, causing the moving contact to separate from the fixed contact, the motor is de-energized, and the squeezing roller stops moving, thereby reducing the possibility of the infusion device bursting after being subjected to strong squeezing.

[0022] Preferably, a pressing block is fixed to the side of the control block, and a pressing groove is formed on the inner wall of the control groove. The pressing block slides vertically with the buffer sleeve through the pressing groove. A pressing spring is fixed to the top surface of the pressing block, and the top end of the pressing spring is fixedly connected to the inner top surface of the pressing groove.

[0023] By adopting the above technical solution, when the floating ring is not in contact with the control block, the control block maintains electrical contact between the moving contact and the fixed contact under the elastic force of the compression spring, thereby energizing the motor.

[0024] Preferably, a vertically arranged guide rod is fixed inside the buffer sleeve, the guide rod passes through the floating ring, and the floating ring slides vertically through the guide rod.

[0025] By adopting the above technical solution, the guide rod provides guidance for the floating ring, so that the floating ring always moves vertically, so that the floating ring can smoothly contact the control block.

[0026] In summary, this application includes at least one of the following beneficial technical effects:

[0027] 1. Place the alginate hydrogel in the sample chamber, then place the simulated body fluid in the infusion device. Open the check valve, and the simulated body fluid enters the splitter through pipe one. The body fluid in the splitter enters the sample chamber through the branch channel and pipe two. After flowing through the sample chamber (containing the alginate hydrogel), it flows into the body fluid recovery pool through pipe three. The flow rate regulator can adjust the flow rate of the simulated body fluid in different pipes two, so that the flow rate of the simulated body fluid is consistent with the flow rate of body fluid in different parts of the human body. This allows for the experimental testing of the degradation rate of the alginate hydrogel in different parts of the human body. The operation is simple and the experimental efficiency is high.

[0028] 2. Close the stop valve, then remove the pagoda connector to take out the alginate hydrogel inside the installation sleeve, weigh it, and calculate the degradation rate of the alginate hydrogel based on the mass change of the alginate hydrogel. The operation is simple and the test cost is low.

[0029] 3. Place the infusion device within the limiting frame, then pass the tubing through the relief groove. The pressure plate abuts against the top of the infusion device to limit its movement. Use the squeezing assembly to squeeze the infusion device, causing the simulated body fluid inside to flow downwards through the tubing. The water temperature in the tank can be controlled by the heating wire to maintain the simulated body fluid inside the infusion device at a constant temperature, reducing the impact of temperature changes on the experimental results. Simultaneously, the temperature can be adjusted to simulate the degradation rate of alginate hydrogel at different body fluid temperatures, thus understanding the effect of different body fluid temperatures on the degradation rate of alginate hydrogel. Attached Figure Description

[0030] Figure 1 This is a schematic diagram of the overall structure of Embodiment 1 of this application.

[0031] Figure 2 This is a schematic diagram of the overall structure of Embodiment 2 of this application.

[0032] Figure 3 This is a cross-sectional view of the water tank in Embodiment 2 of this application.

[0033] Figure 4 This is a schematic diagram of the extrusion roller in Embodiment 2 of this application.

[0034] Figure 5 This is a schematic diagram of the pressure plate in Embodiment 2 of this application.

[0035] Figure 6 This is a cross-sectional view of the slider in Embodiment 2 of this application.

[0036] Figure 7 This is a cross-sectional view of the buffer sleeve in Embodiment 2 of this application.

[0037] Figure 8 yes Figure 7 Enlarged diagram of point A in the middle.

[0038] Attached reference numerals: 1. Infusion device; 11. Pipeline 1; 111. Connecting pipe 1; 112. Connecting pipe 2; 12. Check valve; 13. Diverter; 14. Pipeline 2; 15. Flow regulator; 16. Sample chamber; 161. Mounting sleeve; 162. Pagoda connector; 17. Pipeline 3; 18. Body fluid recovery tank; 2. Temperature control equipment; 21. Water tank; 22. Heating wire; 23. Limiting frame; 231. Through hole 1; 24. Clearance groove; 25. Sliding block; 26. Slide groove; 27. Moving passage 3. Slot; 4. Pressure plate; 5. Fixing block; 6. Fixing rod; 7. Torsion spring; 8. Through hole two; 9. Extrusion roller; 10. Drive screw; 11. Synchronization slot; 12. Motor; 13. Rotating rod; 14. Bevel gear one; 15. Bevel gear two; 16. Synchronization block; 17. Buffer sleeve; 18. Control block; 19. Control slot; 20. Pressing block; 31. Pressing slot; 42. Pressing spring; 53. Moving contact piece; 64. Moving slot; 75. Fixed contact piece; 86. Floating ring; 97. Guide rod. Detailed Implementation

[0039] The following is in conjunction with the appendix Figure 1-8 This application will be described in further detail.

[0040] This application discloses an experimental apparatus for the degradation of alginate hydrogels.

[0041] Example 1

[0042] Reference Figure 1 The experimental apparatus for the degradation of alginate hydrogels includes, from top to bottom, an infusion device 1, a diverter 13, several sample chambers 16, and several body fluid recovery pools 18. The infusion device 1 can be an infusion bag, infusion bottle, etc. A pipe 11 connects the infusion device 1 to the main channel of the diverter 13. Pipe 11 can be a plastic tube, rubber tube, glass tube, etc., and a check valve 12 is installed on pipe 11. The branch channels of the diverter 13 correspond one-to-one with the sample chambers 16. A pipe 2 14 is installed between the branch channels of the diverter 13 and the corresponding sample chambers 16. A flow rate regulator 15 is installed on pipe 2 14. The sample chambers 16 correspond one-to-one with the body fluid recovery pools 18. A pipe 3 17 connects the sample chambers 16 and the corresponding body fluid recovery pools 18.

[0043] Reference Figure 1The sample chamber 16 includes a mounting sleeve 161 for placing samples, and a pagoda connector 162 is installed at the bottom of the mounting sleeve 161. The top end of the pagoda connector 162 is fixedly connected to the bottom of the mounting sleeve 161, and the bottom end of the pagoda connector 162 is connected to the pipe 17. After the degradation experiment is completed, the check valve 12 is closed, and then the pagoda connector 162 is removed, allowing the alginate hydrogel inside the mounting sleeve 161 to be taken out, weighed, and the degradation rate of the alginate hydrogel to be calculated based on the change in mass of the alginate hydrogel.

[0044] The implementation principle of Embodiment 1 of this application is as follows: Alginate hydrogel is placed in sample chamber 16, and simulated body fluid is placed in infusion device 1. The check valve 12 is opened, and the simulated body fluid enters the diverter 13 through pipe 11. The body fluid in the diverter 13 enters the sample chamber 16 through branch channels and pipe 2 14. After flowing through the alginate hydrogel in sample chamber 16, it flows into the body fluid recovery pool 18 through pipe 3 17. The flow rate regulator 15 can adjust the flow rate of the simulated body fluid in different pipes 2 14 so that the flow rate of the simulated body fluid is consistent with the flow rate of body fluid in different parts of the human body. Thus, the degradation rate of alginate hydrogel in different parts of the human body can be tested. The operation is simple and the test efficiency is high.

[0045] Example 2

[0046] Reference Figure 2 , Figure 3 and Figure 4 The difference between Example 2 and Example 1 is that Example 2 also includes a temperature control device 2. The temperature control device 2 includes a water tank 21, and an electric heating wire 22 is installed on the inner wall of the water tank 21. The water temperature inside the water tank 21 can be controlled by controlling the electric heating wire 22. A limiting frame 23 for placing the infusion device 1 is fixed to the inner bottom surface of the water tank 21. Several through holes 231 are opened on the sides of the limiting frame 23, and a clearance groove 24 for placing the pipe 11 is opened on the top surface of the limiting frame 23. The sample chamber 16 is located inside a constant temperature and humidity chamber, and the temperature inside the sample chamber 16 is maintained by the constant temperature and humidity chamber. (Refer to...) Figure 4 and Figure 5 Two fixing blocks 31 are fixed to the top surface of the limiting frame 23, and a fixing rod 32 is rotatably installed between the two fixing blocks 31. A pressure plate 3 is sleeved on the outer periphery of the fixing rod 32, and several through holes 34 are opened on the top surface of the pressure plate 3. A torsion spring 33 is sleeved on the outer periphery of the fixing rod 32. One end of the torsion spring 33 is fixedly connected to the fixing block 31, and the other end of the torsion spring 33 is fixedly connected to the pressure plate 3. After opening the pressure plate 3 and placing the infusion device 1 into the limiting frame 23, the pipe 11 is passed through the relief groove 24. Under the elastic force of the torsion spring 33, the pressure plate 3 rotates downward and abuts against the top surface of the limiting frame 23, and the bottom surface of the pressure plate 3 fits against the infusion device 1, thereby limiting the infusion device 1.

[0047] Reference Figure 4 and Figure 6 The limiting frame 23 has grooves 26 on its inner sides, and a slider 25 is mounted on the limiting frame 23 along its length through the grooves 26. A pressing roller 4 is rotatably mounted between the two sliders 25. A movable channel 27 is provided on the side of the limiting frame 23 away from the pipe 11, and the pressing roller 4 can move into the movable channel 27. A drive screw 41 is rotatably mounted in one of the grooves 26. The drive screw 41 passes through the slider 25, and the slider 25 and the drive screw 41 are threadedly connected. A motor 42 is fixed to the side of the limiting frame 23, and the output end of the motor 42 is fixedly connected to the end of the drive screw 41. Rotating rods 43 are fixed to both ends of the pressing roller 4, and the rotating rods 43 are rotatably connected to the sliders 25. A bevel gear 44 is fixedly sleeved on the outer periphery of one of the rotating rods 43, and a bevel gear 45 is sleeved on the outer periphery of the drive screw 41. The bevel gear 45 meshes with the bevel gear 44. A synchronizing block 46 is fixed on the inner circumferential surface of the bevel gear 45, and a synchronizing groove 412 is provided on the outer circumferential surface of the drive screw 41. The synchronizing block 46 slides and engages with the drive screw 41 along the length direction of the drive screw 41 through the synchronizing groove 412.

[0048] In the initial state, the squeezing roller 4 is located in the moving channel 27. The motor 42 is started, and the motor 42 drives the drive screw 41 to rotate. The drive screw 41 drives the slider 25 to move, which in turn drives the squeezing roller 4 to move towards the pipe 11. At the same time, the drive screw 41 drives the bevel gear 2 45 to rotate through the synchronization block 46 and the synchronization groove 412. The bevel gear 2 45 drives the bevel gear 1 44 to rotate. The bevel gear 1 44 drives the rotating rod 43 to rotate, which in turn drives the squeezing roller 4 to rotate. The squeezing roller 4 squeezes the infusion device 1, so that the simulated body fluid in the infusion device 1 flows smoothly into the pipe 11.

[0049] Reference Figure 2 , Figure 7 and Figure 8 The conduit 11 includes a connecting pipe 111 connected to the infusion device 1 and a connecting pipe 112 connected to the diverter 13. A buffer sleeve 5 is connected between the connecting pipe 111 and the connecting pipe 112. A control groove 52 is provided on the inner top surface of the buffer sleeve 5, and a control block 51 is vertically mounted on the buffer sleeve 5 through the control groove 52. A pressure block 53 is fixed on the side of the control block 51, and a pressure groove 54 is provided on the inner wall of the control groove 52. The pressure block 53 slides vertically with the buffer sleeve 5 through the pressure groove 54. A pressure spring 55 is fixed on the top surface of the pressure block 53, and the top of the pressure spring 55 is fixedly connected to the inner top surface of the pressure groove 54.

[0050] Reference Figure 7 and Figure 8A movable contact 56 is fixed to the side of the control block 51. A movable groove 57 is provided on the inner wall of the control slot 52. The movable contact 56 slides vertically with the buffer sleeve 5 through the movable groove 57. A fixed contact 58 is fixed on the inner bottom surface of the movable groove 57 for electrical contact with the movable contact 56. The fixed contact 58 is electrically connected to the power supply, and the movable contact 56 is electrically connected to the motor 42. A vertically arranged guide rod 61 is fixed inside the buffer sleeve 5. A floating ring 6 is sleeved on the outer periphery of the guide rod 61. The floating ring 6 slides vertically through the guide rod 61, and the top surface of the floating ring 6 can abut against the bottom surface of the control block 51.

[0051] When the motor 42 starts and the squeezing roller 4 squeezes the infusion device 1, the simulated body fluid in the infusion device 1 enters the buffer sleeve 5 through the connecting pipe 111, and then enters the diverter 13 through the connecting pipe 112. As the body fluid in the buffer sleeve 5 gradually increases, the float ring 6 moves upward and comes into contact with the control block 51, thereby pushing the control block 51 to move upward, causing the moving contact 56 to separate from the fixed contact 58. The motor 42 is de-energized, and the squeezing roller 4 stops moving, thereby reducing the possibility of the infusion device 1 bursting after being subjected to strong squeezing.

[0052] The implementation principle of Embodiment 2 of this application is as follows: the infusion device 1 is placed in the limiting frame 23, and then the pipe 11 passes through the relief groove 24. The pressure plate 3 abuts against the top of the infusion device 1, thereby limiting the infusion device 1. The squeezing component is used to squeeze the infusion device 1, so that the simulated body fluid in the infusion device 1 flows downward through the pipe 11. The water temperature in the water tank 21 can be controlled by the heating wire 22, so that the simulated body fluid in the infusion device 1 is kept at a constant temperature, reducing the influence of temperature changes on the test results. At the same time, the degradation rate of alginate hydrogel at different body fluid temperatures can be tested to understand the influence of different body fluid temperatures on the degradation rate of alginate hydrogel.

[0053] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A device for degradation experiments of alginate hydrogels, characterized in that: The device comprises, from top to bottom, a transfusion device (1), a flow divider (13), a plurality of sample chambers (16) and a plurality of body fluid recovery pools (18), a pipe I (11) is connected between the transfusion device (1) and the main channel of the flow divider (13), a flow stop valve (12) is installed on the pipe I (11), the branch channels of the flow divider (13) correspond to the sample chambers (16) one by one, a pipe II (14) is installed between the branch channels of the flow divider (13) and the corresponding sample chambers (16), a flow rate regulator (15) is installed on the pipe II (14), the sample chambers (16) correspond to the body fluid recovery pools (18) one by one, and a pipe III (17) is connected between the sample chambers (16) and the corresponding body fluid recovery pools (18); The device further comprises a temperature control device (2), which comprises a water tank (21), the inner bottom surface of the water tank (21) is fixed with a limiting frame (23) for placing the transfusion device (1), and a pressing assembly is arranged in the limiting frame (23) for pressing the transfusion device (1); The pressing assembly comprises a pressing roller (4), opposite inner sides of the limiting frame (23) are respectively provided with sliding grooves (26), both ends of the pressing roller (4) are respectively provided with sliding blocks (25), the sliding blocks (25) are slidably connected with the limiting frame (23) along the length direction of the limiting frame (23) through the sliding grooves (26), and a moving through slot (27) is formed in the side of the limiting frame (23) away from the pipe I (11), and the pressing roller (4) can move into the moving through slot (27); One of the sliding grooves (26) is rotatably installed with a driving screw (41), the driving screw (41) penetrates through the sliding block (25), the sliding block (25) is threadedly connected with the driving screw (41), the side of the limiting frame (23) is fixed with a motor (42), and the output end of the motor (42) is fixedly connected with the end of the driving screw (41). The pipeline one (11) includes the connecting pipe one (111) connected with the infusion device (1) and the connecting pipe two (112) connected with the shunt (13), the connecting pipe one (111) and the connecting pipe two (112) are connected with the buffer sleeve (5), the inner top surface of the buffer sleeve (5) is provided with the control groove (52), the buffer sleeve (5) is vertically slidably installed with the control block (51) through the control groove (52), the side surface of the control block (51) is fixed with the movable contact (56), the inner wall of the control groove (52) is provided with the moving groove (57), the movable contact (56) is vertically slidably matched with the buffer sleeve (5) through the moving groove (57), the inner bottom surface of the moving groove (57) is fixed with the fixed contact (58) for electrically contacting with the movable contact (56), the fixed contact (58) is electrically connected with the power supply, the movable contact (56) is electrically connected with the motor (42), the buffer sleeve (5) is vertically slidably installed with the floating ring (6) in the inside, the top surface of the floating ring (6) can abut against the bottom surface of the control block (51). When the motor starts and the extrusion roller extrudes the infusion device, the body fluid in the buffer sleeve gradually increases, the floating ring moves upward and abuts against the control block, and then pushes the control block to move upward, so that the movable contact and the fixed contact are separated, the motor is powered off, and the extrusion roller stops moving, thereby reducing the possibility of the infusion device being broken after being strongly extruded.

2. The device for alginate hydrogel degradation experiment according to claim 1, characterized in that: The sample chamber (16) includes an installation sleeve (161) for placing a sample, a boss joint (162) is installed at the bottom of the installation sleeve (161), the top end of the boss joint (162) is fixedly connected with the bottom of the installation sleeve (161), and the bottom end of the boss joint (162) is communicated with the pipeline three (17).

3. The device for alginate hydrogel degradation experiment according to claim 2, characterized in that: The inner wall of the water tank (21) is provided with an electric heating wire (22), the side surface of the limiting frame (23) is provided with a plurality of through holes one (231), the limiting frame (23) is provided with a pressing plate (3), the bottom surface of the pressing plate (3) can abut against the infusion device (1), the top surface of the pressing plate (3) is provided with a plurality of through holes two (34), and the top surface of the limiting frame (23) is provided with a gap slot (24) for placing the pipeline one (11).

4. The device for alginate hydrogel degradation experiment according to claim 3, characterized in that: The two ends of the extrusion roller (4) are respectively fixed with rotating rods (43), the rotating rods (43) are rotationally connected with the sliding blocks (25), one of the rotating rods (43) is fixedly sleeved with a bevel gear one (44), the driving screw (41) is sleeved with a bevel gear two (45), the bevel gear two (45) is meshed with the bevel gear one (44), the inner circumferential surface of the bevel gear two (45) is fixed with a synchronous block (46), the outer circumferential surface of the driving screw (41) is provided with a synchronous groove (412), and the synchronous block (46) is slidably matched with the driving screw (41) along the length direction of the driving screw (41) through the synchronous groove (412).

5. The device for alginate hydrogel degradation experiment according to claim 3, characterized in that: The top surface of the limiting frame (23) is fixed with two fixed blocks (31), the two fixed blocks (31) are rotationally installed with a fixed rod (32), the pressing plate (3) is sleeved on the outer periphery of the fixed rod (32), the bottom surface of the pressing plate (3) can abut against the top surface of the limiting frame (23), the outer periphery of the fixed rod (32) is sleeved with a torsion spring (33), one end of the torsion spring (33) is fixedly connected with the fixed block (31), and the other end of the torsion spring (33) is fixedly connected with the pressing plate (3).

6. A device for the degradation of alginate hydrogels according to claim 5, characterized in that: The side surface of the control block (51) is fixed with a pressing block (53), the inner wall of the control groove (52) is provided with a pressing groove (54), the pressing block (53) is vertically slidably connected with the buffer sleeve (5) through the pressing groove (54), and the top surface of the pressing block (53) is fixed with a pressing spring (55).

7. The alginate hydrogel degradation assay device of claim 1, wherein: The buffer sleeve (5) is fixedly provided with a vertically arranged guide rod (61), the guide rod (61) penetrates through the floating ring (6), and the floating ring (6) vertically slides through the guide rod (61).

Images