Blood sampling and collecting device in animal test

Abstract

The invention discloses a blood sampling and collecting device in animal experiments, which comprises a base, a collecting basin is fixed on the base, a rotating drum is rotatably arranged on the collecting basin, a certain gap is formed between the outer wall of the rotating drum and the inner wall of the collecting basin, a plurality of clamping grooves are distributed on the circumference of the outer wall of the rotating drum, and test tubes can be placed in the clamping grooves. A driving motor connected to the rotary drum is arranged in the base; a support is fixed to the side wall of the collecting basin, a suction assembly is arranged on the support, the lower portion of the suction assembly corresponds to the circumferential position where the clamping groove is located, a hose is connected to the suction assembly, and a needle head is connected to the tail end of the hose. Compared with the prior art, the invention provides an efficient, accurate and economical blood sampling solution through the innovation of automatic test tube alternation, closed negative pressure collection and intelligent cleaning.

Description

Technical Field

[0001] The present invention relates to the technical field of blood sampling and collection, and specifically to a blood sampling and collection device in animal experiments. Background Art

[0002] In biomedical research, drug development, and toxicology experiments, the analysis of animal blood samples is a key means to evaluate physiological status, pharmacokinetics, and toxicological responses. Efficient and accurate blood collection can ensure the reliability of experimental data.

[0003] Currently, animal blood collection mainly relies on manual blood collection. The operator directly holds a syringe to puncture the animal's blood vessel, and after drawing blood, manually transfers it to a test tube. It can only collect a single sample, and for large-scale experiments, test tubes need to be frequently changed, which is time-consuming and laborious. Semi-automatic blood collection devices use a fixed test tube rack in combination with an electric suction pump, but still require manual placement of test tubes and sample switching, and cannot achieve continuous collection. Interrupted operation affects the experimental rhythm. Fully automatic high-throughput blood collection systems integrate robotic arms and conveyor belts, which can achieve automatic switching and transportation of test tubes, but they require a large amount of disposable consumables, and multi-module independent control occupies a large space, making it difficult to adapt to the conventional laboratory environment and unable to achieve the efficient combination of continuous collection and closed cleaning.

[0004] Therefore, it is necessary to provide a blood sampling and collection device in animal experiments to solve the problems raised in the above background art. Summary of the Invention

[0005] To achieve the above object, the present invention provides the following technical solution: A blood sampling and collection device in animal experiments, including a base, a collection basin is fixed on the base, a rotating cylinder is rotatably arranged on the collection basin, there is a certain gap between the outer wall of the rotating cylinder and the inner wall of the collection basin, a plurality of card slots are circumferentially distributed on the outer wall of the rotating cylinder, test tubes can be placed in the card slots, and a driving motor connected to the rotating cylinder is arranged in the base;

[0006] A support is fixed on the side wall of the collection basin, a suction assembly is arranged on the support, the lower part of the suction assembly corresponds to the circumferential position where the card slots are located, a hose is connected to the suction assembly, and the end of the hose is connected to a needle.

[0007] Further, an input conveyor belt and an output conveyor belt are respectively arranged around the collection basin, and the input conveyor belt and the output conveyor belt penetrate into the gap between the collection basin and the rotating cylinder.

[0008] Further, the suction assembly includes a housing, a blood collection tube and a suction tube are fixed on the housing, the blood collection tube is connected to the hose, and the suction tube is connected to a suction pump fixed on the support.

[0009] Furthermore, a rubber plug ring that penetrates into the interior of the housing is slidably provided below the bottom of the housing. The rubber plug ring is fixed in a support ring inside the housing, and a plurality of springs are provided between the upper part of the support ring and the top of the housing.

[0010] Furthermore, an arc-shaped convex block is provided at the position of the bottom of the collection basin corresponding to the location of the bracket.

[0011] Furthermore, an inner cylinder is fixed inside the housing. The inner cylinder penetrates through the housing vertically. A sliding cover is slidably provided above the inner cylinder. A dropper and a suction head are respectively fixed below the sliding cover. The blood collection tube and the suction tube respectively penetrate through the dropper and the suction head slidably.

[0012] Furthermore, a rotating cover is rotatably provided below the inner cylinder. When the rotating cover rotates to a horizontal state, it can seal the lower part of the inner cylinder.

[0013] Furthermore, a cleaning liquid cylinder is fixed in the bracket, and a clamping plate is fixed in the bracket at the position above the cleaning liquid cylinder.

[0014] Furthermore, a central gear is rotatably provided on the front and rear of the outer wall of the inner cylinder. A first rack and a second rack that mesh with the central gear are respectively slidably provided on both sides of each central gear. Each first rack is fixed in the support ring, and each second rack is fixed in a connecting bar. The connecting bar is fixed above the sliding cover.

[0015] Furthermore, both ends of the rotating shaft of the rotating cover penetrate outside the inner cylinder and are fixed with driven gears, and the driven gears mesh with the central gears in the corresponding directions.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0017] In the present invention, the card slots distributed circumferentially on the rotating cylinder cooperate with the input / output conveyor belt to realize the automatic supply and recovery of test tubes, without the need for manual frequent replacement of test tubes, which is especially suitable for large-scale animal experiments.

[0018] In the present invention, the elastic seal between the rubber plug ring and the test tube mouth combines with the negative pressure of the suction pump to ensure the stable inhalation of blood into the test tube. The sliding cover drives the dropper and the suction head to extend into the interior of the test tube, avoiding blood splashing into the suction assembly.

[0019] In the present invention, the rotating cover in the horizontal state can seal the inner cylinder to form a closed cleaning circuit. The needle is fixed to the cleaning liquid cylinder through the clamping plate, and the suction pump is used to flush the hose, the blood collection tube and the inner cylinder, which can thoroughly remove the residual blood, avoid sample contamination, and can be directly used for the next blood collection after cleaning, reducing the consumption of disposable consumables.

[0020] In the present invention, the test tube is lifted to trigger the gear rack, which synchronously controls the downward movement of the dripper and the opening of the rotating cover, thereby reducing manual intervention, and the spring ensures that each component automatically returns to its position. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the structure of a blood sampling and collecting device in animal experiments;

[0022] Figure 2 It is a schematic diagram of the structure inside the collection basin;

[0023] Figure 3 It is a schematic diagram of the structure inside the suction component;

[0024] Figure 4 is a schematic diagram of the cross-sectional structure of the suction component;

[0025] In the figure: 1. base; 2. collecting basin; 21. arc-shaped protrusion; 3. rotating drum; 31. card slot; 4. input conveyor belt; 5. output conveyor belt; 6. test tube; 7. bracket; 8. suction assembly; 81. shell; 82. blood collection tube; 83. suction tube; 84. inner cylinder; 85. sliding cover; 86. dripper; 87. suction head; 88. rotating cover; 89. rubber plugging ring; 810. support ring; 811. spring; 812. center gear; 813. first rack; 814. second rack; 815. driven gear; 816. connecting strip; 9. hose; 10. needle; 11. suction pump; 12. card plate; 13. cleaning liquid cylinder. DETAILED DESCRIPTION

[0026] See also Figures 1-4 In an embodiment of the present invention, a blood sampling and collecting device in an animal experiment includes a base 1, a collecting basin 2 is fixed on the base 1, a rotating drum 3 is rotatably arranged on the collecting basin 2, an outer wall of the rotating drum 3 and an inner wall of the collecting basin 2 have a certain gap, a plurality of slots 31 are distributed on the outer wall of the rotating drum 3, a test tube 6 can be placed in the slot 31, and a driving motor connected to the rotating drum 3 is arranged in the base 1;

[0027] A bracket 7 is fixed to the side wall of the collection basin 2, and a suction assembly 8 is arranged on the bracket 7. The lower part of the suction assembly 8 corresponds to the circumferential position of the card slot 31. The suction assembly 8 is connected to a hose 9, and a needle 10 is connected to the end of the hose 9.

[0028] Blood sampling is performed on the animal by manually operating the hose 9 and the needle 10. When the needle 10 pierces the animal's blood vessel, the blood in the animal's blood vessel flows along the hose 9 into the suction assembly 8 through the suction assembly 8, and drips from the bottom of the suction assembly 8 into the test tube 6 in the collection basin 2. By rotating the drum 3, different test tubes 6 can pass under the suction assembly 8 in turn, thereby quickly completing blood sampling.

[0029] In this embodiment, an input conveyor belt 4 and an output conveyor belt 5 are respectively arranged around the collection basin 2, and the input conveyor belt 4 and the output conveyor belt 5 penetrate into the gap between the collection basin 2 and the rotary drum 3.

[0030] That is to say, the test tube can be continuously input and output into the collection basin 2 through the input conveyor belt 4 and the output conveyor belt 5.

[0031] In this embodiment, the suction assembly 8 includes a housing 81, a blood collection tube 82 and a suction pipe 83 are fixed on the housing 81, the blood collection tube 82 is connected to a hose 9, and the suction pipe 83 is connected to a suction pump 11 fixed on a bracket 7.

[0032] That is to say, when both the blood collection tube 82 and the suction pipe 83 are connected to the test tube 6 and kept in a sealed state, a negative pressure can be generated in the test tube 6 through the suction pump 11, so that the blood in the animal blood vessel drips into the test tube 6 along the hose 9.

[0033] In this embodiment, a rubber plug ring 89 penetrating into the interior of the housing 81 is slidably arranged below the bottom of the housing 81, the rubber plug ring 89 is fixed in a support ring 810 inside the housing 81, and a plurality of springs 811 are arranged between the upper part of the support ring 810 and the top of the housing 81.

[0034] When the test tube 6 moves to be concentric with the rubber plug ring 89, moving the test tube 6 upward can make its opening fit with the rubber plug ring 89 with a certain pressure, thereby sealing the opening of the test tube 6.

[0035] In this embodiment, an arc-shaped convex block 21 is arranged at the position corresponding to the bracket 7 at the bottom of the collection basin 2.

[0036] When the test tube 6 moves to the position of the bracket 7 along with the rotation of the rotary drum 3, its bottom contacts the arc-shaped convex block 21 to lift the test tube 6, which will cause the test tube 6 to move upward by a certain distance, so that the test tube 6 fits with the rubber plug ring 89.

[0037] In this embodiment, an inner cylinder 84 is fixed inside the housing 81, the inner cylinder 84 penetrates the housing 81 up and down, a sliding cover 85 is slidably arranged above the inner cylinder 84, a drip head 86 and a suction head 87 are respectively fixed below the sliding cover 85, and the blood collection tube 82 and the suction pipe 83 respectively penetrate through the drip head 86 and the suction head 87 slidably.

[0038] That is to say, by sliding the sliding cover 85, the heights of the drip head 86 and the suction head 87 can be changed, so that the drip head 86 and the suction head 87 can extend into the test tube 6 to avoid blood splashing into the inner cylinder 84 when the blood suction is unstable.

[0039] In this embodiment, a rotating cover 88 is rotatably arranged below the inner cylinder 84. When the rotating cover 88 rotates to the horizontal state, it can seal the lower part of the inner cylinder 84.

[0040] By controlling the rotation of the rotating cover 88 to the horizontal or vertical state, the inner cylinder 84 and the test tube 6 can be sealed or communicated with each other. And when the rotating cover 88 is in the vertical state, the sliding cover 85 slides down, and the dropper head 86 and the suction head 87 can penetrate from one side of the rotating cover 88 to the lower part of the rotating cover 88 to enter the interior of the test tube 6.

[0041] In this embodiment, a cleaning liquid cylinder 13 is fixed in the bracket 7, and a clamping plate 12 is fixed in the bracket 7 at a position above the cleaning liquid cylinder 13.

[0042] The hose 9 can be clamped in the clamping plate 12, so that the needle 10 is in the cleaning liquid cylinder 13 filled with cleaning liquid. And when the needle 10 is in the cleaning liquid cylinder 13 filled with cleaning liquid and the rotating cover 88 rotates to the horizontal state, since the inner cylinder 84 is in a sealed state, when the suction pump 11 is started at this time, the cleaning liquid in the cleaning liquid cylinder 13 can flow along the hose 9 into the inner cylinder 84 and be discharged out of the discharge port of the suction pump 11 along the suction pipe 83, thereby cleaning the needle 10, the hose 9, the blood collection tube 82 and the dropper head 86, and avoiding cross-contamination caused by residual blood during the next blood sampling.

[0043] In this embodiment, central gears 812 are rotatably arranged on the front and rear outer walls of the inner cylinder 84. On both sides of each central gear 812, a first rack 813 and a second rack 814 meshing with it are slidably arranged. Each first rack 813 is fixed to the support ring 810, and each second rack 814 is fixed to the connecting bar 816. The connecting bar 816 is fixed above the sliding cover 85.

[0044] That is to say, under the action of the central gear 812, the first rack 813 and the second rack 814 always slide in opposite directions. Once the test tube 6 moves up and pushes up the rubber plug ring 89 and the support ring 810, the sliding cover 85 and the dropper head 86 and the suction head 87 will slide down, so that the dropper head 86 and the suction head 87 extend into the test tube 6.

[0045] In this embodiment, both ends of the rotating shaft of the rotating cover 88 penetrate outside the inner cylinder 84 and are fixed with driven gears 815, and the driven gears 815 mesh with the central gears 812 in the corresponding directions.

[0046] That is to say, when the sliding cover 85 and the dropper head 86 and the suction head 87 slide down, the rotating cover 88 will synchronously open to the vertical state for the dropper head 86 and the suction head 87 to pass through.

[0047] During specific implementation:

[0048] The rotary drum 3 rotates, moving the empty test tube 6 to directly below the suction assembly 8. The bottom of the test tube 6 contacts the arc-shaped bump 21 of the collection basin 2 and is pushed up. The mouth of the test tube is hermetically fitted with the rubber plug ring 89. At this time, the support ring 810 moves up, the first rack 813 pushes the central gear 812 to rotate, the second rack 814 pulls down the sliding cover 85, the central gear 812 synchronously drives the driven gear 815, and the rotating cover 88 rotates to the vertical state. The dropper 86 and the suction head 87 extend into the test tube;

[0049] Remove the needle 10 from the clamping plate 12, puncture the blood vessel of the animal, start the suction pump 11, and the blood drips into the test tube 6 along the hose 9, the blood collection tube 82, and the dropper 86;

[0050] After the current test tube collection is completed, the drive motor rotates the rotary drum 3 to move the test tube 6 away from directly below the suction assembly 8. At this time, the spring 811 rebounds to move the support ring 810 down. Similarly, the dropper 86 and the suction head 87 retract into the inner cylinder 84 and the rotating cover 88 is in the horizontal state;

[0051] Clamp the hose 9 to the clamping plate 12 so that the needle 10 is in the cleaning liquid cylinder 13, start the suction pump 11, and the cleaning liquid flows along the hose 9, the blood collection tube 82, the inner cylinder 84, and the suction tube 83, and is discharged after flushing the pipeline;

[0052] Repeating the above steps can perform continuous blood sampling. The collected test tube rotates with the rotary drum to the position of the output conveyor belt 5 and is automatically sent out of the collection basin 2.

[0053] The above is only the preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

Claims

1. A blood sampling and collection device for animal experiments, characterized in that, It includes a base (1), a collection basin (2) is fixed on the base (1), a rotating cylinder (3) is rotatably arranged on the collection basin (2), there is a certain gap between the outer wall of the rotating cylinder (3) and the inner wall of the collection basin (2), a plurality of card slots (31) are circumferentially distributed on the outer wall of the rotating cylinder (3), test tubes (6) can be placed in the card slots (31), and a driving motor connected to the rotating cylinder (3) is arranged in the base (1). A bracket (7) is fixed on the side wall of the collection basin (2), a suction assembly (8) is arranged on the bracket (7), the lower part of the suction assembly (8) corresponds to the circumferential position where the card slots (31) are located, a hose (9) is connected to the suction assembly (8), and the end of the hose (9) is connected to a needle (10).

2. The blood sampling and collection device in an animal experiment according to claim 1, wherein, An input conveyor belt (4) and an output conveyor belt (5) are respectively arranged around the collection basin (2), and the input conveyor belt (4) and the output conveyor belt (5) penetrate into the gap between the collection basin (2) and the rotating cylinder (3).

3. The blood sampling and collection device in an animal experiment according to claim 1, characterized in that, The suction assembly (8) includes a housing (81), a blood collection tube (82) and a suction tube (83) are fixed on the housing (81), the blood collection tube (82) is connected to the hose (9), and the suction tube (83) is connected to a suction pump (11) fixed on the bracket (7).

4. An animal experiment blood sampling and collection device according to claim 3, wherein, A rubber plug ring (89) penetrating into the interior of the housing (81) is slidably arranged below the bottom of the housing (81), the rubber plug ring (89) is fixed in a support ring (810) inside the housing (81), and a plurality of springs (811) are arranged between the upper part of the support ring (810) and the top of the housing (81).

5. The blood sampling and collection device in an animal experiment according to claim 1, characterized in that, An arc-shaped convex block (21) is arranged at the bottom of the collection basin (2) corresponding to the position of the bracket (7).

6. The blood sampling and collection device in an animal experiment according to claim 4, characterized in that, An inner cylinder (84) is fixed inside the housing (81), the inner cylinder (84) penetrates the housing (81) up and down, a sliding cover (85) is slidably arranged above the inner cylinder (84), a drip head (86) and a suction head (87) are respectively fixed below the sliding cover (85), and the blood collection tube (82) and the suction tube (83) respectively penetrate through the drip head (86) and the suction head (87) slidably.

7. The blood sampling and collection device in an animal experiment according to claim 6, characterized in that, A rotating cover (88) is rotatably arranged below the inner cylinder (84), and when the rotating cover (88) rotates to a horizontal state, it can seal the lower part of the inner cylinder (84).

8. The blood sampling and collection device in an animal experiment according to claim 1, characterized in that, A cleaning liquid cylinder (13) is fixed in the bracket (7), and a clamping plate (12) is fixed in the bracket (7) at the upper position of the cleaning liquid cylinder (13).

9. The blood sampling and collection device in animal experiments according to claim 7, characterized in that, Central gears (812) are rotatably arranged on the front and rear of the outer wall of the inner cylinder (84), a first rack (813) and a second rack (814) meshing with each central gear (812) are respectively slidably arranged on both sides of each central gear (812), each first rack (813) is fixed in the support ring (810), each second rack (814) is fixed in a connecting strip (816), and the connecting strip (816) is fixed above the sliding cover (85).

10. The blood sampling and collection device in an animal experiment according to claim 9, characterized in that Both ends of the rotating shaft of the rotating cover (88) penetrate outside the inner cylinder (84) and are fixed with driven gears (815), and the driven gears (815) are engaged with the central gears (812) in the corresponding directions.

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