Antibacterial toothpaste

Abstract

The invention discloses toothpaste with efficient antibacterial and whitening functions. The core component of the toothpaste is a 2D / 2D KNbO / MoSpiezoelectric heterojunction nano material and tea polyphenol composite system. The KNbO / MoSheterojunction is synthesized through a hydrothermal method, the specific surface area reaches 11.13 m / g, the average pore size is 28.81 nm, and the antibacterial rate on escherichia coli within 3 minutes of ultrasonic treatment is 70%, and the antibacterial rate on staphylococcus aureus is 60.03%. The tea polyphenol (1-5mM) is preferably ester catechin (EGCG: ECG = 1: 1), and can synergistically enhance the inhibition on oral pathogenic bacteria (such as streptococcus mutans). According to the toothpaste, active oxygen sterilization is triggered by mechanical force through a piezoelectric-chemical synergistic effect, meanwhile, pigments are degraded, and the toothpaste has the functions of non-invasive whitening and enamel protection.

Description

Technical Field

[0001] The present invention relates to the technical field of oral care materials, and specifically to a composite toothpaste based on piezoelectric-polyphenol synergistic antibacterial effect. Background Art

[0002] In the prior art, traditional antibacterial toothpastes rely on chemical bactericides such as chlorhexidine, which easily lead to the imbalance of oral flora; most whitening toothpastes use peroxides, which damage tooth enamel. Although nano-zinc oxide antibacterial toothpaste has been proposed, its antibacterial efficiency is low and it has no mechanical responsiveness. The present invention solves the above problems by combining the piezoelectric catalysis of 2D / 2D KNbO3 / MoS2 heterojunction with the targeted antibacterial effect of tea polyphenols. Summary of the Invention

[0003] Core innovation points: Material design: The KNbO3 / MoS2 heterojunction is prepared by a hydrothermal method (Example 1). The modification of MoS2 nanosheets increases the specific surface area by more than 40%, promoting charge separation under ultrasound; Tea polyphenols are preferably mixed with EGCG:ECG = 1:1, and their o-quinone intermediates can enhance the damage to the cell membrane of Gram-positive bacteria (see the antibacterial experiment in Example 3).

[0004] Synergistic mechanism: Brushing mechanical force → KNbO3 / MoS2 piezoelectric polarization → generation of ·OH / O2 - → Destroy the bacterial cell membrane; Tea polyphenols penetrate the damaged bacterial membrane and further inhibit metabolism through thiol binding. Specific Embodiments

[0005] Example 1 (Preparation of KNbO3 / MoS2) Synthesize the KM-10 heterojunction according to the following steps: Dissolve 5.5 g of KOH and 1.404 g of Nb2O5 in 100 mL of ethylene glycol, react at 200 °C for 8 h, and calcine at 900 °C for 2 h to obtain KNbO3 nanosheets; Take 0.5 g of KNbO3, 0.195 g of Na2MoO4·2H2O, and 0.39 g of thiourea and react at 200 °C for 24 h in 60 mL of 0.075 M oxalic acid; The product is washed with ethanol and dried at 60 °C to obtain a heterojunction with 10% mass fraction of MoS2.

[0006] Example 2 (Toothpaste formulation) Mix by weight percentage: KNbO3 / MoS2 5% Green tea extract (EGCG 60%) 0.3% Sorbitol (humectant) 20% Sodium lauryl sulfate (foaming agent) 1.5% Sodium carboxymethyl cellulose (thickener) 1% The balance is deionized water.

[0007] Example 3 (Performance test) Antibacterial property (GB / T 20944.3-2008): The antibacterial rate against Streptococcus mutans is 98.2% (ultrasonic treatment for 3 min); Compared with commercially available chlorhexidine toothpaste (antibacterial rate 91.5%), there is no bacterial drug resistance.

[0008] Whitening property (ISO 28399:2013): After treating coffee-stained teeth for 7 days, the ΔE value increases by 4.8, which is better than the hydrogen peroxide group (ΔE 3.2) and there is no enamel damage.

Claims

1. An antibacterial toothpaste, characterized in that, It contains the following components: Piezoelectric material: 2D / 2D KNbO3 / MoS2 heterojunction nanoparticles with a specific surface area of 8–15 m² / g and an average pore diameter of 20–35 nm; Antibacterial synergist: tea polyphenols with a concentration of 1–5 mM; Toothpaste matrix: including foaming agent, humectant, and thickener.

2. The antibacterial toothpaste according to claim 1, wherein: In the KNbO3 / MoS2 heterojunction, the mass fraction of MoS2 is 5–20%.

3. The antibacterial toothpaste according to claim 1, wherein: The tea polyphenols are derived from green tea extract with an EGCG content of ≥50%.

4. The antibacterial toothpaste according to claim 1, wherein: The piezoelectric material generates hydroxyl radicals (·OH) and superoxide radicals (O2 - ) under the action of mechanical brushing force, and synergistically inhibits Streptococcus mutans and Porphyromonas gingivalis with tea polyphenols.

5. The antibacterial toothpaste according to claim 1, characterized in that Adding tea polyphenols with a concentration of 1–5 mM, in which the molar ratio of the ester-type catechins EGCG to ECG is 1:1–2:1, and the oxidized condensed theaflavins and thearubigins, can inhibit more than 80% of Streptococcus mutans and Staphylococcus aureus.