Quick-drying hand-washing-free disinfection gel and preparation method thereof

Abstract

The invention relates to the technical field of disinfection gels, and discloses a quick-dry hand-washing-free disinfection gel and a preparation method thereof.The disinfection gel is prepared from, by weight, 70%-80% of ethyl alcohol, 0.3%-0.8% of carbomer, 0.1%-1% of glycosylglycerol, 0.05%-0.5% of hydroxyethyl cellulose, 0.05%-0.2% of triethanolamine, 1%-5% of a humectant, 0.15%-0.9% of an anti-allergy agent, 0.02%-0.1% of a soothing agent and the balance water. The storage time of the disinfection gel can be prolonged, so that the service life is prolonged, and the sterilization effect of the disinfection gel is kept.

Description

Technical Field

[0001] This application relates to the technical field of handwashing and disinfection gels, and particularly to a quick-drying and waterless hand disinfection gel and its preparation method. Background Art

[0002] The quick-drying and waterless hand disinfection gel is a portable disinfection product made with alcohol (usually 70%-80% ethanol) as the core bactericidal ingredient, combined with a gel matrix, humectants, and functional additives. Its emergence is closely related to the upgrading of public health needs. Especially due to its characteristics of not requiring a water source and rapid sterilization, it has quickly become an important tool for personal protection and epidemic prevention in public places.

[0003] The core advantages of the quick-drying and waterless hand disinfection gel lie in the balance between rapid sterilization and convenience. The alcohol component can kill 99.9% of common pathogens (such as Escherichia coli and Staphylococcus aureus) within 30 seconds, and the gel texture avoids the fluidity problem of liquid disinfectants, making it convenient to carry and use. The formulation is also constantly being improved and optimized. For example, adding moisturizing ingredients such as hyaluronic acid can relieve the irritation of alcohol to the skin, and honeysuckle plant extracts endow the product with natural antibacterial and soothing effects. Although the above components can improve the comfort of the disinfection gel, during the use of the quick-drying and waterless hand disinfection gel, due to the volatile nature of ethanol, after the product is unsealed and stored for a certain period of time, the ethanol concentration is likely to decrease and the bactericidal ability is weakened. Summary of the Invention

[0004] In order to extend the service life of the quick-drying and waterless hand disinfection gel, this application provides a quick-drying and waterless hand disinfection gel. By using a compound of carbomer, glucosyl glycerol, hydroxyethyl cellulose, and triethanolamine in the formulation, a more stable network structure is formed, which is not prone to molecular chain curling and has a good wrapping effect on ethanol molecules. As a result, the storage time of the disinfection gel is greatly extended, and the disinfection effect is not easily weakened due to ethanol volatilization.

[0005] In the first aspect, this application provides a quick-drying and waterless hand disinfection gel, adopting the following technical solution: A quick-drying and waterless hand disinfection gel, by weight percentage, comprises the following components: ethanol 70-80%, carbomer 0.3-0.8%, glucosyl glycerol 0.1-1%, hydroxyethyl cellulose 0.05-0.5%, triethanolamine 0.05-0.2%, humectant 1-5%, anti-allergy agent 0.15-0.9%, soother 0.02-0.1%, and the balance is water.

[0006] By adopting the above technical solution, carbomer, as the gel component in the disinfection gel, can form a gel network, adsorb and lock in moisture, provide a long-lasting moisturizing effect for the skin, reduce moisture loss, and cooperate with ethanol to provide a certain antibacterial effect; and glyceroglucoside, hydroxyethyl cellulose and triethanolamine are added to the components. Glyceroglucoside has good film-forming properties and can form a structure similar to small capsules with the other components, thereby strengthening the action on ethanol, thus slowing down the ethanol volatilization rate. Hydroxyethyl cellulose forms a three-dimensional network structure through the entanglement of molecular chains, and cooperates with carbomer to improve the stability of the gel state and wrap ethanol molecules, thereby reducing the decrease in viscosity and ethanol volatilization. Triethanolamine promotes the stretching of carbomer chain segments, thereby promoting the formation of a three-dimensional network structure by carbomer and hydroxyethyl cellulose, so as to better wrap ethanol. Therefore, through the compound use of carbomer and glyceroglucoside, hydroxyethyl cellulose and triethanolamine, they not only have good compatibility in the system, but also can interact synergistically to form a more stable network structure, improve the action on ethanol molecules, and thus reduce the weakening of the bactericidal effect caused by the decrease in ethanol content after storage for a period of time.

[0007] Optionally, by weight percentage, it includes the following components: ethanol 75 - 80%, carbomer 0.5 - 0.6%, glyceroglucoside 0.4 - 0.6%, hydroxyethyl cellulose 0.2 - 0.3%, triethanolamine 0.1 - 0.15%, moisturizer 3 - 4%, anti-allergy agent 0.3 - 0.5%, soother 0.02 - 0.1%, and the balance is water.

[0008] By adopting the above technical solution, by further defining each component, the obtained disinfection gel has better effects.

[0009] Optionally, the anti-allergy agent includes bisabolol and purslane extract, and the weight ratio of bisabolol to purslane extract is 1:(2 - 10).

[0010] By adopting the above technical solution, it can promote the penetration of moisturizing components, repair the sebum membrane, reduce transdermal water loss. The combination of bisabolol and purslane extract can not only enhance the antibacterial and antiviral abilities of the product, but also significantly improve the irritation of the high-alcohol-content formula to the skin.

[0011] Optionally, the moisturizer is selected from glycerol.

[0012] By adopting the above technical solution, the moisturizer is selected from glycerol, which relieves skin dryness caused by ethanol and reduces defatting irritation. In addition, glycerol can form hydrogen bonds with ethanol and cooperate with other components to delay its volatilization rate, thereby further increasing the storage time of the hand sanitizer gel.

[0013] Optionally, the soother is selected from aloe powder.

[0014] By adopting the above technical solution, the aloe powder can not only enhance the moisturizing and soothing effects, but also improve the adsorption capacity of ethanol through its natural polysaccharide structure, thereby prolonging the shelf life of the product.

[0015] Optionally, the mass ratio of carbomer, glucosyl glycerol, hydroxyethyl cellulose and triethanolamine is 5:5:1:1.

[0016] Optionally, by weight percentage, it further includes 0.2 - 0.4% of allantoin.

[0017] By adopting the above technical solution, allantoin has multiple effects such as repair, moisturizing, and anti - inflammation. At the same time, it can form multiple hydrogen - bond interactions with ethanol, further synergizing with other components to delay the volatilization of ethanol.

[0018] In a second aspect, the present application provides a quick - drying hand - sanitizing gel.

[0019] A preparation method of a quick - drying hand - sanitizing gel includes the following steps: (1) Dissolve hydroxyethyl cellulose in a part of water, stir until dissolved under heating conditions, and then add the remaining water to obtain a hydroxyethyl cellulose solution; (2) Under stirring conditions, add carbomer to the hydroxyethyl cellulose solution, let it stand and then stir evenly until melted to obtain a homogeneous mixture of hydroxyethyl cellulose and carbomer; (3) Add ethanol to a container, and while stirring, add glucosyl glycerol, a moisturizer, an anti - allergen, and a soother until evenly mixed to obtain a mixture; (4) Filter the homogeneous mixture obtained in step (2) through a 200 - 400 mesh sieve, and add it to the mixture obtained in step (3), stir evenly, and keep standing for 1 h; (5) Add a triethanolamine solution to the mixture in step (4) and stir evenly to obtain the quick - drying hand - sanitizing gel.

[0020] Optionally, in step (1), the heating temperature is 70 - 80°C.

[0021] In summary, the present application includes at least one of the following beneficial effects: 1. By the compound use of carbomer, glucosyl glycerol, hydroxyethyl cellulose and triethanolamine in the component formulation, a more stable network structure is formed, which is not easy to occur molecular chain curling and has a good wrapping force on ethanol molecules, thereby greatly improving the shelf life of the sanitizing gel and not easily reducing the disinfection effect due to ethanol volatilization; 2. By using glycerol as a humectant, not only can the wetting effect of the disinfection gel be improved, but it can also cooperate with other components in the form of hydrogen bonding to reduce the volatilization of ethanol. Detailed implementation manners

[0022] The present application will be further described in detail below in conjunction with embodiments.

[0023] Example 1: Prepare raw materials. Calculated by 100 parts by weight, 70 parts of ethanol, 0.3 part of carbomer, 0.1 part of glucosylglycerol, 0.05 part of hydroxyethyl cellulose, 0.05 part of triethanolamine, 1 part of humectant (selected from glycerol), 0.15 part of anti-allergy agent (the anti-allergy agent is selected from bisabolol and purslane extract, and the mass ratio of bisabolol to purslane extract is 1:2), 0.02 part of soother (selected from aloe powder), and the balance is purified water.

[0024] The preparation of the disinfection gel includes the following steps: (1) Add hydroxyethyl cellulose to 10% of the total amount of water in the formula, heat to 70 - 80 °C to promote the dissolution of hydroxyethyl cellulose, and continuously stir. After the hydroxyethyl cellulose is dissolved, add the remaining water to obtain a hydroxyethyl cellulose solution; (2) Under stirring conditions, add carbomer to the above-mentioned hydroxyethyl cellulose solution, let it stand for 30 minutes, and then stir evenly to dissolve to obtain a homogeneous mixture of hydroxyethyl cellulose and carbomer; (3) Add 95% ethanol to the reaction kettle, and while stirring, add glycerol, glucosylglycerol, aloe powder, bisabolol and purslane extract until completely mixed evenly; (4) Filter the homogeneous mixture obtained in step (2) through a 200 - 400 mesh sieve, add the filtered homogeneous mixture to the mixture obtained in step (3), stir evenly, and let it stand for 1 h to eliminate air bubbles; (5) Add a 20% aqueous solution of triethanolamine to the mixture in step (4), and stir slowly and evenly to prepare a quick-drying hand sanitizing gel.

[0025] Example 2: Prepare raw materials. Calculated by 100 parts by weight, 75 parts of ethanol, 0.5 part of carbomer, 0.4 part of glucosylglycerol, 0.2 part of hydroxyethyl cellulose, 0.1 part of triethanolamine, 3 parts of humectant (selected from glycerol), 0.3 part of anti-allergy agent (the anti-allergy agent is selected from bisabolol and purslane extract, and the mass ratio of bisabolol to purslane extract is 1:10), 0.02 part of soother (selected from aloe powder), and the balance is purified water.

[0026] The preparation of the disinfection gel includes the following steps: (1) Add hydroxyethyl cellulose to 10% of the total amount of water in the formulation, heat it to 70 - 80 °C to promote the dissolution of hydroxyethyl cellulose, and continuously stir. After the hydroxyethyl cellulose is dissolved, add the remaining water to obtain a hydroxyethyl cellulose solution; (2) Under stirring conditions, add carbomer to the above-mentioned hydroxyethyl cellulose solution, let it stand for 30 minutes, and then stir evenly until it melts to obtain a homogeneous mixture of hydroxyethyl cellulose and carbomer; (3) Add 95% ethanol to the reaction kettle, and while stirring, add glycerol, glucosylglycerol, aloe powder, bisabolol, and purslane extract until completely mixed evenly; (4) Filter the homogeneous mixture obtained in step (2) through a 200 - 400 mesh sieve, add the filtered homogeneous mixture to the mixture obtained in step (3), stir evenly, and keep it standing for 1 h to eliminate air bubbles; (5) Add a 20% aqueous solution of triethanolamine to the mixture in step (4), and stir slowly and evenly to prepare a quick-drying hand sanitizing gel.

[0027] Example 3: This example has the same process steps and components as Example 2, except for the different raw material dosages. Calculated by 100 parts by weight, 80 parts of ethanol, 0.8 part of carbomer, 1 part of glucosylglycerol, 0.5 part of hydroxyethyl cellulose, 0.2 part of triethanolamine, 5 parts of moisturizer (selected from glycerol), 0.9 part of anti-allergy agent (the anti-allergy agent is selected from bisabolol and purslane extract, and the mass ratio of bisabolol to purslane extract is 1:10), 0.1 part of soother (selected from aloe powder), and the balance is purified water.

[0028] Example 4: This example has the same process steps and components as Example 2, except for the different raw material dosages. Calculated by 100 parts by weight, 80 parts of ethanol, 0.5 part of carbomer, 0.6 part of glucosylglycerol, 0.3 part of hydroxyethyl cellulose, 0.15 part of triethanolamine, 4 parts of moisturizer (selected from glycerol), 0.5 part of anti-allergy agent (the anti-allergy agent is selected from bisabolol and purslane extract, and the mass ratio of bisabolol to purslane extract is 1:10), 0.1 part of soother (selected from aloe powder), and the balance is purified water.

[0029] Example 5: This example has the same process steps and components as Example 2, except for the different raw material dosages. Calculated by 100 parts by weight, 75 parts of ethanol, 0.5 part of carbomer, 0.5 part of glucosylglycerol, 0.1 part of hydroxyethyl cellulose, 0.1 part of triethanolamine, 2 parts of moisturizer (selected from glycerol), 0.45 part of anti-allergy agent (the anti-allergy agent is selected from bisabolol and purslane extract, and the mass ratio of bisabolol to purslane extract is 1:2), 0.2 part of soother (selected from aloe powder), and the balance is purified water.

[0030] Example 6. The process steps and component contents of this example are the same as those of Example 5, except that it further includes 0.3 parts of allantoin.

[0031] Comparative Example 1. The process steps and component contents of this comparative example are the same as those of Example 1, except that an equal amount of glucosylglycerol is used to replace hydroxyethyl cellulose.

[0032] Comparative Example 2. The process steps and component contents of this comparative example are the same as those of Example 1, except that an equal amount of hydroxyethyl cellulose is used to replace glucosylglycerol.

[0033] Comparative Example 3. The process steps and component contents of this comparative example are the same as those of Example 1, except that an equal amount of glucosylglycerol is used to replace triethanolamine.

[0034] Performance test: The opened product is placed in an oven at 38 ± 1°C for 90 days, and the active ingredient (ethanol) on the 1st day and the 90th day is tested by gas chromatography, and the decrease rate of the active ingredient is calculated. Decrease rate = (original active ingredient concentration - active ingredient concentration after testing) / original active ingredient concentration * 100%.

[0035] The decrease rates of the ethanol concentrations of Examples 1 - 6 and Comparative Examples 1 - 3 are as follows in the table:

[0036] By comparing Examples 5 and 6, it can be seen that by adding allantoin to the components, the decrease rate of the active ingredient (ethanol) is lower in the constant-temperature test environment, indicating that allantoin can cooperate with other components to enhance the interaction force on ethanol molecules, thereby reducing the volatilization of ethanol, improving the service life of the disinfection gel product. After 90 days of the opened product, the ethanol content still remains at a high level, thus maintaining the bactericidal and disinfecting effect.

[0037] By comparing Example 1 with Comparative Examples 1 - 3, it can be seen that hydroxyethyl cellulose, glucosylglycerol, and triethanolamine can cooperate with each other to better promote the stability of ethanol molecules in the disinfection gel, thereby greatly improving the storage time of the disinfection gel product after being opened.

[0038] The above are all the preferred embodiments of this application. The protection scope of this application is not limited by this. Therefore, all equivalent changes made according to the structure, shape, and principle of this application should be covered within the protection scope of this application.

Claims

1. A quick-drying hand sanitizing gel without rinsing, characterized in that: By weight percentage, it comprises the following components: ethanol 70 - 80%, carbomer 0.3 - 0.8%, glucosyl glycerol 0.1 - 1%, hydroxyethyl cellulose 0.05 - 0.5%, triethanolamine 0.05 - 0.2%, humectant 1 - 5%, anti - allergy agent 0.15 - 0.9%, soother 0.02 - 0.1%, and the balance is water.

2. The quick-drying hand sanitizing gel according to claim 1, wherein: By weight percentage, it comprises the following components: ethanol 75 - 80%, carbomer 0.5 - 0.6%, glucosyl glycerol 0.4 - 0.6%, hydroxyethyl cellulose 0.2 - 0.3%, triethanolamine 0.1 - 0.15%, humectant 3 - 4%, anti - allergy agent 0.3 - 0.5%, soother 0.02 - 0.1%, and the balance is water.

3. The quick-drying hand sanitizing gel according to claim 2, wherein: The anti - allergy agent comprises bisabolol and purslane extract, and the weight ratio of bisabolol to purslane extract is 1:(2 - 10).

4. A quick-drying hand sanitizing gel according to claim 1, wherein: The humectant is selected from glycerol.

5. The instant-drying hand-free disinfectant gel according to claim 1, wherein: The soother is selected from aloe powder.

6. The quick-drying hand sanitizing gel according to claim 5, wherein: The mass ratio of carbomer, glucosyl glycerol, hydroxyethyl cellulose and triethanolamine is 5:5:1:

1.

7. The instant-drying hand sanitizing gel according to claim 1, characterized in that: By weight percentage, it further comprises 0.2 - 0.4% of allantoin.

8. A method for preparing a quick-drying hand sanitizing gel without rinsing according to any one of claims 1-6, characterized in that: It comprises the following steps: (1) Dissolve hydroxyethyl cellulose in part of water, stir until dissolved under heating conditions, and add the remaining water to obtain a hydroxyethyl cellulose solution; (2) Under stirring conditions, add carbomer to the hydroxyethyl cellulose solution, let it stand and then stir evenly until melted to obtain a homogeneous substance of hydroxyethyl cellulose and carbomer; (3) Add ethanol to a container, and while stirring, add glucosyl glycerol, humectant, anti - allergy agent, soother until evenly mixed to obtain a mixture; (4) Filter the homogeneous substance obtained in step (2) through a 200 - 400 mesh sieve, and add it to the mixture obtained in step (3), stir evenly, and keep standing for 1 h; (5) Add the triethanolamine solution to the mixture in step (4), and stir evenly to obtain the quick - drying hand - sanitizing gel.

9. The preparation method of a quick-drying hand-free hand sanitizing gel according to claim 8, characterized in that: In step (1), the heating temperature is 70 - 80 °C.

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