Ganoderma lucidum and mesona chinensis preparation for treating uremia
The Lingzhi Xiancao Uremia Treatment herbal formulation addresses the lack of effective treatments for chronic kidney diseases by regulating kidney function and reducing urea levels, enabling patients to live normal lives.
Patent Information
- Application Number
- CN202510520307.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-17
- Publication Date
- 2025-07-15
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing technology cannot effectively cure uremia. Traditional Chinese and Western medicine treatment can only alleviate the condition. Dialysis therapy has a burden on patients' lives and is difficult for young patients to bear for a long time.
Combined with the Ganoderma lucidum recipe from our ancestors, we added a variety of Chinese herbal medicines such as rapeseed, water prickly, pierced stone, embroidery needle, etc. to make Ganoderma lucidum uremicang preparation. Through multiple clinical trials, the prescription is optimized to enhance the effect of treating uremia.
Significantly reduces serum creatinine levels, improves renal function, controls blood sugar and liver function, reduces complications, and improves patients' quality of life.
Abstract
Description
[0001] Technical Field: The present invention belongs to the field of traditional Chinese medicine preparations. This prescription is an improved version of the ancestral Ganoderma lucidum and fairy herb prescription by adding some Chinese herbal medicines, specifically the Ganoderma lucidum and fairy herb uremia rehabilitation preparation.
[0002] Background Art: With the development of society and the progress of industry, the environment and climate are constantly changing. In the past decade, the number of patients suffering from uremia has been increasing. Several cases can be found among every thousand people. Uremia (i.e., renal failure) is a clinical comprehensive disease caused by the gradual development of various chronic kidney diseases, which severely damages the renal parenchyma. The main causes are the continuous progression of kidney diseases such as glomerulonephritis, chronic pyelonephritis, kidney stones, renal tuberculosis, prostatic hyperplasia, malignant hypertension, hyperglycemia, hyperuricemia, and hereditary nephritis. The clinical manifestations include various syndromes such as pale, sallow or grayish-black complexion, eyelid edema, elevated blood pressure, arrhythmia, dry and itchy skin, rashes, fetid breath, fatigue, dizziness, drowsiness, etc. In the late stage, symptoms such as diarrhea, severe anemia, gastrointestinal perforation, bleeding, tremors, pericarditis, pleurisy, deep breathing, and pathological fractures occur. The incidence rate of this disease is high, and the recurrence rate and mortality rate are also relatively high. The existing traditional Chinese and Western medicine treatments can only relieve the condition and prolong life, and there is no specific and radical treatment method. The dialysis therapy requires high skills, and it is extremely difficult for ordinary patients to bear it for a long time. Especially for those young patients, once they start dialysis, they cannot work normally, and the burden on society and families is unimaginable. Based on the ancestral Ganoderma lucidum and fairy herb prescription and with family members as the core, with the help of several veteran Chinese medicine doctors, through adding various Chinese herbal medicines and conducting hundreds of clinical trials, a major breakthrough has been achieved in the treatment of this disease, and the clinical effect is good.
[0003] SUMMARY OF THE INVENTION: The Ganoderma lucidum and Mesona chinensis Uremia-Kang preparation is composed of: Ganoderma lucidum, Mesona chinensis (Mesona procumbens), Polygonatum sibiricum, Astragalus membranaceus, Taraxacum mongolicum, Cirsium setosum, Gardenia jasminoides, Lonicera japonica, Pilea microphylla, Kyllinga brevifolia, Cudrania tricuspidata, each 10 g - 100 g; Saururus chinensis, Momordica charantia, Saururus chinensis, Glycyrrhiza glabra, Plantago asiatica, Leonurus japonicus, Agrimonia pilosa, each 4 g - 40 g; Angelica sinensis, Rheum palmatum, Lygodium japonicum, Microsorum fortunei (Pyrrosia lingua), Akebia trifoliata, Imperata cylindrica, Lophatherum gracile, Epimedium brevicornu, Poria cocos, Hemerocallis fulva, Cirsium setosum, Lysimachia christinae, Curculigo orchioides, each 2 g - 20 g. Ganoderma lucidum is a traditional Chinese medicinal material, and its main effects include enhancing immunity, regulating metabolism, antioxidation, protecting the liver, and calming the nerves and promoting sleep; Pilea microphylla (scientific name: Pilea microphylla) is a plant of the genus Pilea in the family Urticaceae. It is commonly called "stone amaranth", "peperomia" etc. in folk. The whole herb can be used as medicine, and its main effects include clearing heat and detoxifying, reducing swelling and alleviating pain, and promoting diuresis and relieving stranguria. It is traditionally used to relieve sore throat, traumatic injury, sores and ulcers, etc. Modern research shows that it may contain active ingredients such as flavonoids, volatile oils, etc., and has potential effects such as antibacterial, anti-inflammatory, and antioxidation; Kyllinga brevifolia (the Chinese medicine name, the whole herb of the plant Kyllinga brevifolia in the Cyperaceae family) is a traditional Chinese medicinal material, with the effects of clearing heat and detoxifying, reducing swelling and alleviating pain, dispelling wind and removing dampness, etc., and is mainly used to treat cold and fever, cough and sore throat, rheumatic arthralgia, skin eczema, traumatic injury, etc.; Astragalus membranaceus has the effects of invigorating qi and refreshing the mind, enhancing the body surface defense, reducing sweating, eliminating edema, improving blood circulation, relieving arthralgia, expelling toxins from the body, and eliminating abscesses, etc.; Saururus chinensis (the Chinese medicine name, also known as Damnacanthus indicus, Damnacanthus officinalis) is a traditional Chinese medicinal material. Its dried root or whole herb is used as medicine. Its main effects are dispelling wind and dampness, promoting blood circulation and reducing swelling, clearing heat and detoxifying, and is commonly used to relieve rheumatic pain, traumatic injury and gynecological problems; Momordica charantia is a plant with both medicinal and edible uses. Its main effects include clearing heat and relieving summer heat, assisting in regulating blood sugar, promoting digestion, antioxidation, and regulating blood lipid. The main treatment directions cover relieving summer heat and thirst, assisting in controlling diabetes, improving skin problems, etc.; Saururus chinensis is a traditional Chinese medicinal material. Its dried rhizome or whole herb is used as medicine, with the effects of clearing heat and detoxifying, promoting diuresis and reducing swelling, antibacterial and anti-inflammatory, etc., and is commonly used to treat damp-heat jaundice, edema, sores and ulcers, etc. Modern research also finds that it has a certain effect on regulating immunity; Leonurus japonicus mainly plays a role by regulating uterine contraction, promoting blood circulation, preventing thrombus formation, protecting heart blood supply, increasing urine output, and inhibiting fungal infection, etc.; Agrimonia pilosa: has the effects of quickly stopping bleeding, relieving inflammation, alleviating pain, inhibiting the growth of cancer cells, regulating blood sugar and blood pressure, helping the wound to stop bleeding quickly, and can fight malaria and vaginal parasite infection, etc., and can help restore physical strength and improve complexion; Lygodium japonicum: has pharmacological effects such as clearing heat and promoting diuresis, relieving stranguria and pain, etc., and is commonly used to treat urinary tract infections, calculi, etc.; Hemerocallis fulva is the dried root of the plant Hemerocallis fulva in the Liliaceae family. As a traditional Chinese medicinal material, it has the effects of clearing heat and promoting diuresis, reducing swelling and promoting diuresis, cooling blood and detoxifying, calming the nerves and relieving uneasiness, etc., and is applicable to damp-heat, edema, insomnia, etc.Centella asiatica helps prevent and improve urinary tract stones, promotes bile secretion to aid digestion, excretes small stones by increasing urine output, inhibits bacterial infection, reduces inflammatory response, regulates overactive immune response, and delays cell aging; Curculigo can regulate weak constitution, help enhance immunity, relieve hypoxia discomfort, relieve inflammatory pain, protect liver function and prevent bone loss; we have conducted many experiments on every herb in the prescription, no matter how it is composed, it is very safe, and the monarch, minister, adjuvant and envoy can be flexibly changed. The ancestral Lingzhi Xiancao prescription is composed of Lingzhi, Xiancao (Liangfencao), Polygonatum, Astragalus, Dandelion, Thistle, Gardenia, and Honeysuckle. It was mainly used to treat nephritis and kidney stones at that time. Later, with the help of many old Chinese medicine practitioners, I have performed hundreds of trials on it. Clinical trials have added rapeseed, water centipede, piercing stone, rust needle, bitter melon, three white grass, licorice, plantain, motherwort, agrimony, angelica, rhubarb, sea gold sand, Jiangnan star fern, August lily, white hair root, light bamboo leaf, epimedium, cloud Poria, small thistle, money grass, daylily root, and curculigo to further improve the prescription and expand the scope of treatment, especially in the treatment of uremia has made a major breakthrough, so this prescription is also named Lingzhi Xiancao Uremia Kang Preparation; doctors and patients are well known that the creatinine of patients with nephritis will increase day by day as the disease progresses, and finally develop into uremia (renal failure). During the treatment process, the reversal of blood creatinine becomes a problem. Through long-term clinical trials, I found that this preparation has a good conditioning effect on blood creatinine. ;
[0004] Preparation method: Lingzhixiancao Uremic Kang preparation is composed of 10kg each of Lingzhi, Xiancao (Liangfencao), Polygonatum, Astragalus, Dandelion, Honeysuckle, Thistle, Gardenia, Petroleum rape, Water centipede, and Chuanpo stone, 4kg each of embroidery needle, bitter melon, Three White Grass, Licorice, Plantain, Motherwort, and Agrimonia, 2kg each of Angelica, Rhubarb, Sea Gold Sand, Jiangnan Star Fern (Stone Reed), August Fern, White Hair Root, Light Bamboo Leaf, Epimedium, Poria, Hemerocallis Root, Thistle, Money Grass, and Curculigo. First, make each Chinese medicine into a 10:1 extract. The powder of each extract is then put together and evenly mixed, packaged into 100 grams per bottle, and stored at room temperature. This is the best preparation method of the present invention. I made a lot of comparisons. Only by extracting each Chinese medicine separately and then mixing them can the best therapeutic effect be achieved. If they are mixed first and then extracted together to make the preparation, the efficacy of the product will be greatly reduced. The appearance of this difference may be caused by the chemical reaction between them at high temperature after mixing, which causes the loss of the effective ingredients.
[0005] Dosage and administration: 2-3 times a day, 3g-15g each time, taken with warm water.
[0006] Example: <1> , Deng XX, female, 56 years old, had a heart disease that could not be cured for a long time. Due to long-term medication, her fasting blood sugar was 24mmol / L. She took a lot of western medicine and could not control it with metformin hydrochloride. Later, she injected insulin. Her blood sugar was sometimes high and sometimes low, and her condition was very unstable. Later, she developed edema in the lower limbs, urine protein +++, creatinine 750μmol / L, hepatitis B, liver cirrhosis and a small amount of ascites. At the same time, she was found to have renal cysts and kidney stones. Her liver function was not normal, and her transaminase was 160U / L. She came to my place for treatment on July 9, 2018. I prescribed her the above preparation method The prepared Lingzhi Xiancao Uremic Kang preparation <stop taking other Chinese and Western medicines> was taken twice a day, 15 grams each time, for 45 days. The blood sugar was 8mmol / L, urine protein turned negative, creatinine dropped to 200μmol / L, there were no kidney cysts and kidney stones, liver function was normal, various complications disappeared, and blood sugar was significantly controlled. After taking it for 7 consecutive months, the medicine was stopped. Ultrasound examination showed no cirrhosis and ascites, hepatitis B virus had turned negative, creatinine was normal, and other indicators of liver and kidney function were normal. Follow-up for three years showed normal blood sugar, normal liver and kidney function, no discomfort, and no other symptoms recurred.
[0007] <2> , Yu XX, male, 68 years old, likes to eat high-fat food, is 1.56 meters tall, weighs more than 150 kilograms, has high blood pressure, high blood lipids, pharyngitis, cough, stomatitis, blood sugar fluctuates between 19mmol / L and 25mmol / L, blood creatinine is 658uml / L, urea nitrogen is 35uml / L, uric acid is 580uml / L (since the age of 62, he needs to take various western medicines on time every day, but there is no obvious improvement in his health. He feels abnormal after stopping the medicine for one to two days. Moreover, his creatinine was only 130uml / L at that time, and it increased year by year. In April 2017, his creatinine reached 658uml / L). I lost confidence in the treatment of western medicine because of no improvement after taking western medicine for a long time. On May 8, 2017, I came to our place to take the Lingzhi Xiancao Uremic Kang preparation prepared according to this preparation method, twice a day, 10g each time. After two months, the dosage was halved. After taking the medicine, my blood pressure, blood sugar, and blood lipids were normal, my blood creatinine dropped to 358uml / L, urea was 10uml / L, and uric acid was normal. The effect was ideal. After taking it for another six months, my blood pressure, blood sugar and various blood indicators were all normal. In the future, I will check my blood creatinine regularly, and they are all within the normal range. I have been healthy ever since.
[0008] <3>, Fan XX, male, 65 years old. On February 8, 2010, due to a cold, he had headache, cough, accompanied by dry mouth, frequent urination, blood in urine and feces. After long-term treatment in the local area, the condition did not improve. The cough recurred and worsened, accompanied by weakness in breathing, tachycardia, and at the same time, he had asthma, pulmonary heart disease, stomatitis, and diabetes. The uric acid in renal function was 600 uml / L, creatinine was 750 uml / L, and urea nitrogen was 38 μml / L. After taking traditional Chinese and Western medicines, there was no obvious improvement. For more than one year, he always felt unwell all over, and all functional indicators continued to rise. Due to damaged renal function, he could not live a normal life and sometimes could not even take care of himself. On May 8, 2011, he came to our place and took the Ganoderma lucidum and fairy herb uremia-kang preparation prepared according to this preparation method, 15 g each time, 3 times a day. After using it for 30 days, he felt significantly better. After continuing to use it for 9 months and going to the hospital for reexamination, there was no cerebral arteriosclerosis, pharyngitis, or stomatitis. Renal function and blood sugar were normal, and asthma had been controlled. Since then, during regular reexaminations, liver and renal functions and creatinine have always been within the normal range. He has not relapsed since stopping the medicine. Now he can work normally and is in good health.
Claims
1. The Ganoderma lucidum Xiancao Uremia Kang preparation is characterized in that The preparation is made from 10 g - 100 g each of Ganoderma lucidum, Mesona chinensis Benth., Polygonatum sibiricum Redoute, Astragalus membranaceus (Fisch.) Bunge, Taraxacum mongolicum Hand.-Mazz., Cirsium setosum (Willd.) MB., Gardenia jasminoides Ellis, Lonicera japonica Thunb., Pilea cavaleriei Levl., Saururus chinensis (Lour.) Baill., Cudrania tricuspidata (Carr.) Bur. ex Lavallee; 4 g - 40 g each of Prunella vulgaris L., Momordica charantia L., Saururus chinensis (Lour.) Baill., Glycyrrhiza uralensis Fisch., Plantago asiatica L., Leonurus japonicus Houtt., Agrimonia pilosa Ledeb.; and 2 g - 20 g each of Angelica sinensis (Oliv.) Diels, Rheum palmatum L., Lygodium japonicum (Thunb.) Sw., Lepisorus thunbergianus (Kaulf.) Ching, Akebia trifoliata (Thunb.) Koidz., Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb., Lophatherum gracile Brongn., Epimedium brevicornu Maxim., Poria cocos (Schw.) Wolf, Hemerocallis fulva L., Cirsium setosum (Willd.) MB., Lysimachia christinae Hance, Curculigo orchioides Gaertn..
2. The Ganoderma lucidum and Mesona chinensis Benth. uremia - relieving preparation according to claim 1 is made from 10 g of Ganoderma lucidum, 10 parts of Pilea cavaleriei Levl., 10 parts of Saururus chinensis (Lour.) Baill., 10 parts of Cudrania tricuspidata (Carr.) Bur. ex Lavallee, 10 g of Astragalus membranaceus (Fisch.) Bunge, 4 parts of Prunella vulgaris L., 4 parts of Momordica charantia L., 4 parts of Saururus chinensis (Lour.) Baill., 4 parts of Glycyrrhiza uralensis Fisch., 4 parts of Plantago asiatica L., 4 parts of Leonurus japonicus Houtt., 4 parts of Agrimonia pilosa Ledeb., 2 parts of Angelica sinensis (Oliv.) Diels, 2 parts of Rheum palmatum L., 2 parts of Lygodium japonicum (Thunb.) Sw., 2 parts of Lepisorus thunbergianus (Kaulf.) Ching (or Lepisorus thunbergianus (Kaulf.) Ching), 2 parts of Akebia trifoliata (Thunb.) Koidz., 2 parts of Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb., 2 parts of Lophatherum gracile Brongn., 2 parts of Epimedium brevicornu Maxim., 2 parts of Poria cocos (Schw.) Wolf, 2 parts each of Cirsium setosum (Willd.) MB., Lysimachia christinae Hance, Hemerocallis fulva L., Curculigo orchioides Gaertn..