Integrated proton treatment system and method based on online diagnosis and treatment and electronic equipment

Abstract

The invention discloses an integrated proton treatment system and method based on online diagnosis and treatment and electronic equipment, and relates to the technical field of proton treatment. The system comprises an online diagnosis and treatment module used for obtaining theoretical patient state information in advance, obtaining a treatment scheme according to the theoretical patient state information and a preset treatment scheme, and performing proton treatment on the patient; the data acquisition module is used for acquiring actual patient state information and actual treatment parameter information; the data processing module is used for obtaining a first information deviation between the actual patient state information and the theoretical patient state information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; and the real-time feedback module is used for sending the first information deviation and the second information deviation to the online diagnosis and treatment module, so that the online diagnosis and treatment module performs patient positioning adjustment according to the first information deviation and updates a preset treatment scheme according to the second information deviation and the treatment scheme after the proton treatment of the patient is completed.

Description

Technical Field

[0001] The present invention relates to the technical field of proton therapy, and particularly to an integrated proton therapy system, method and electronic device based on online diagnosis and treatment. Background Art

[0002] In the proton therapy scheme in the related art, it is necessary to collect images of a patient several days or weeks before treatment, so as to delineate the tumor target area and formulate a preset treatment scheme according to the image collection results for proton radiotherapy. However, due to the uncertainty caused by the malignant growth of the tumor, the preset treatment scheme generated in advance may not reflect the changes caused by the malignant growth of the tumor during the process of image collection and treatment, affecting the effect of image-guided proton therapy. Summary of the Invention

[0003] The present invention aims to at least solve one of the technical problems in the related art to some extent. For this purpose, the first object of the present invention is to propose an integrated proton therapy system based on online diagnosis and treatment to improve the effect of proton therapy.

[0004] The second object of the present invention is to propose an integrated proton therapy method based on online diagnosis and treatment.

[0005] The third object of the present invention is to propose an electronic device.

[0006] To achieve the above object, an integrated proton therapy system based on online diagnosis and treatment according to an embodiment of the first aspect of the present invention includes: an online diagnosis and treatment module, configured to obtain theoretical patient status information in advance, obtain a current treatment plan according to the theoretical patient status information and a preset treatment plan, and perform proton therapy on the current patient according to the current treatment plan; a data collection module, configured to collect actual patient status information and actual treatment parameter information; a data processing module, connected to the data collection module, configured to obtain a first information deviation between the actual patient status information and the theoretical patient status information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; and a real-time feedback module, connected to the data processing module and the online diagnosis and treatment module, configured to send the first information deviation and the second information deviation to the online diagnosis and treatment module, so that the online diagnosis and treatment module adjusts the patient positioning according to the first information deviation, and updates the preset treatment plan according to the second information deviation and the current treatment plan after completing the proton therapy on the current patient.

[0007] In addition, the integrated proton therapy system based on online diagnosis and treatment according to an embodiment of the present invention may further have the following additional technical features:

[0008] In one embodiment of the present invention, the data acquisition module includes: an X-ray imaging acquisition device, configured to acquire a patient's image using X-rays and use the acquired X-ray image as the actual patient status information.

[0009] In one embodiment of the present invention, the online diagnosis and treatment module includes a proton therapy device configured to emit a proton beam to the patient for proton therapy of the patient. The data acquisition module further includes: a range information acquisition device, configured to acquire the rays generated when the proton beam irradiates the patient, obtain the actual range of the proton beam based on the rays, and use the actual range as the actual treatment parameter information.

[0010] In one embodiment of the present invention, the data acquisition module further includes: a simulated CT device, configured to acquire a simulated CT image of the patient and use the simulated CT image of the patient as the theoretical patient status information.

[0011] In one embodiment of the present invention, the data processing module is further configured to: after the online diagnosis and treatment module completes the proton therapy of the patient, update the preset treatment plan according to all the second information deviations obtained during the proton therapy of the patient by the online diagnosis and treatment module.

[0012] In one embodiment of the present invention, the theoretical patient status information is the information acquired within 24 hours before the current proton therapy of the patient.

[0013] To achieve the above object, a second aspect embodiment of the present invention proposes an integrated proton therapy method based on online diagnosis and treatment. The method includes: obtaining theoretical patient status information in advance, obtaining the current treatment plan according to the theoretical patient status information and the preset treatment plan; performing the current proton therapy of the patient according to the current treatment plan, and acquiring the actual patient status information and the actual treatment parameter information; obtaining a first information deviation between the actual patient status information and the theoretical patient status information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; adjusting the patient's positioning according to the first information deviation, and updating the preset treatment plan according to the second information deviation and the current treatment plan after completing the current proton therapy of the patient.

[0014] In addition, the integrated proton therapy method based on online diagnosis and treatment according to the embodiments of the present invention further has the following additional technical features:

[0015] In one embodiment of the present invention, the theoretical patient status information is the information acquired within 24 hours before the current proton therapy of the patient.

[0016] In an embodiment of the present invention, the actual patient status information includes X-ray images, the actual treatment parameter information includes the actual range, and the theoretical patient status information includes the patient's simulated CT images; wherein, the X-ray images are images obtained by collecting patient images using X-rays, the actual range is the actual range of the proton beam obtained based on the positron nuclide generated when the proton beam irradiates the patient, and the patient's simulated CT images are images obtained by using a simulated CT device for collection.

[0017] To achieve the above object, an embodiment of the third aspect of the present invention provides an electronic device, including a memory, a processor, and a computer program stored on the memory and running on the processor. When the computer program is executed by the processor, the above-mentioned integrated proton therapy method based on online diagnosis and treatment is implemented.

[0018] According to the integrated proton therapy system, method, and electronic device based on online diagnosis and treatment of the embodiments of the present invention, the system includes: an online diagnosis and treatment module, configured to pre-obtain theoretical patient status information, obtain the current treatment plan based on the theoretical patient status information and a preset treatment plan, and perform proton therapy on the current patient according to the current treatment plan; a data acquisition module, configured to acquire actual patient status information and actual treatment parameter information; a data processing module, connected to the data acquisition module, configured to obtain a first information deviation between the actual patient status information and the theoretical patient status information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; a real-time feedback module, connected to the data processing module and the online diagnosis and treatment module, configured to send the first information deviation and the second information deviation to the online diagnosis and treatment module, so that the online diagnosis and treatment module adjusts the patient's positioning according to the first information deviation, and updates the preset treatment plan according to the second information deviation and the current treatment plan after completing the proton therapy on the current patient. Through this system, when performing proton therapy on a patient in the online diagnosis module, treatment can be carried out based on the pre-obtained theoretical patient status information, thereby avoiding the influence of changes caused by the malignant growth of tumors during the process of image acquisition and treatment on the effect of proton therapy.

[0019] Additional aspects and advantages of the present invention will be given in part in the following description, become apparent in part from the following description, or be understood through the practice of the present invention. Description of the Drawings

[0020] Figure 1 is a structural block diagram of the integrated proton therapy system based on online diagnosis and treatment according to an embodiment of the present invention;

[0021] Figure 2 is a flowchart of the integrated proton therapy method based on online diagnosis and treatment according to an embodiment of the present invention;

[0022] Figure 3It is a structural block diagram of the electronic device according to an embodiment of the present invention. Detailed implementation manners

[0023] The integrated proton therapy system, method and electronic device based on online diagnosis and treatment according to the embodiments of the present invention will be described below with reference to the accompanying drawings, in which the same or similar reference numerals represent the same or similar elements or elements with the same or similar functions throughout. The embodiments described with reference to the accompanying drawings are exemplary and should not be construed as limiting the present invention.

[0024] Figure 1 It is a structural block diagram of the integrated proton therapy system based on online diagnosis and treatment according to an embodiment of the present invention.

[0025] As Figure 1 shown, the integrated proton therapy system 100 based on online diagnosis and treatment includes: an online diagnosis and treatment module 101, configured to pre-obtain theoretical patient state information, obtain the current treatment plan according to the theoretical patient state information and a preset treatment plan, and perform proton therapy on the current patient according to the current treatment plan; a data acquisition module 102, configured to acquire actual patient state information and actual treatment parameter information; a data processing module 103, connected to the data acquisition module 102, configured to obtain a first information deviation between the actual patient state information and the theoretical patient state information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; a real-time feedback module 104, connected to the data processing module 103 and the online diagnosis and treatment module 101, configured to send the first information deviation and the second information deviation to the online diagnosis and treatment module 101, so that the online diagnosis and treatment module 101 adjusts the patient positioning according to the first information deviation, and updates the preset treatment plan according to the second information deviation and the current treatment plan after completing the proton therapy on the current patient.

[0026] Specifically, the integrated proton therapy system 100 based on online diagnosis and treatment is set to include an online diagnosis and treatment module 101, a data acquisition module 102, a data processing module 103, and a real-time feedback module 104. A preset treatment plan is pre-generated, so that the online diagnosis and treatment module 101 can perform treatment on the patient to be treated based on the preset treatment plan, and realize proton therapy for the patient.

[0027] While the online diagnosis and treatment module 101 performs proton therapy on the patient, the data acquisition module 102 needs to perform data acquisition, and needs to simultaneously acquire the state of the patient and the working state of the online diagnosis and treatment module 101 to obtain actual patient state information and actual treatment parameter information.

[0028] After obtaining the actual treatment information, the data processing module 103 obtains the information deviation between the actual treatment information and the theoretical treatment information, including the above-mentioned first information deviation and second information deviation, so as to update the preset treatment plan according to the information deviation, so that the online diagnosis and treatment module 101 can perform proton therapy on the patient according to the updated plan.

[0029] The above-mentioned real-time feedback module 104 and data processing module 103 can be implemented by electronic devices set on the online platform. The above-mentioned data acquisition module 102 can be implemented by specific acquisition devices and their supporting electronic devices. The above-mentioned online diagnosis and treatment module 101 can be implemented by diagnosis and treatment devices (such as treatment couches) and their supporting electronic devices. Moreover, the supporting electronic devices of the online diagnosis and treatment module 101 and the data acquisition module 102 can also be set on the online platform.

[0030] Among them, the treatment of the patient by the online diagnosis and treatment module 101 is fractionated treatment to improve the treatment effect and reduce the damage caused by proton therapy to the patient's body. Therefore, it is set that before each proton therapy for the patient, the online diagnosis and treatment module 101 pre-obtains the theoretical patient status information, and adjusts the currently stored preset treatment plan according to the theoretical patient status information to obtain the treatment plan for this time. Thus, it is possible to avoid the influence of the changes caused by the malignant growth of the tumor during the process of image acquisition and treatment on the effect of proton therapy.

[0031] The above-mentioned theoretical patient status information includes theoretical patient positioning information, the position information of the patient's lesion (such as a tumor), the shape information of the patient's lesion, etc. The above-mentioned actual patient status information includes actual patient positioning information, the position information of the patient's lesion (such as a tumor), the shape information of the patient's lesion, etc. The above-mentioned theoretical treatment parameter information includes the irradiation angle, irradiation depth, dose distribution, etc. of the theoretical proton beam. The above-mentioned actual treatment parameter information includes the irradiation angle, irradiation depth, dose distribution, etc. of the actual proton beam.

[0032] After obtaining the treatment plan for this time, the online diagnosis and treatment module 101 performs proton therapy on the patient according to the treatment plan for this time. And during the treatment, it is necessary to obtain the actual patient status information and the actual treatment parameter information.

[0033] The above-mentioned treatment plan for this time includes information such as the patient's position and proton range during this treatment process. That is to say, when performing this patient's proton therapy according to the treatment plan for this time, it is necessary to first move the patient's position according to the treatment plan for this time, and then irradiate the patient with a proton beam according to the treatment plan for this time.

[0034] After moving the patient's position according to the current treatment plan, the actual patient information can be obtained, and then the first information difference between the actual patient status information and the theoretical patient status information can be obtained, so as to adjust the patient's positioning according to the first information difference. For example, if the tumor position in the actual patient status information is inconsistent with the tumor position in the theoretical patient status information, the patient's positioning can be adjusted to adjust the tumor position to the position in the theoretical patient status information.

[0035] Moreover, after adjusting the tumor position to the position in the theoretical patient status information and performing proton beam irradiation on the patient, the second information difference between the actual treatment parameter information and the theoretical treatment parameter information is also obtained. Then, after the completion of this proton therapy, the preset treatment plan is updated according to the second information difference and the current treatment plan, so as to enable subsequent fractional treatments to be carried out according to the updated treatment plan.

[0036] Therefore, an integrated proton therapy system 100 based on online diagnosis and treatment is provided, including: an online diagnosis and treatment module 101, which is used to pre-obtain the theoretical patient status information, obtain the current treatment plan according to the theoretical patient status information and the preset treatment plan, and perform the current patient proton therapy according to the current treatment plan; a data acquisition module 102, which is used to collect the actual patient status information and the actual treatment parameter information in real time during the current patient proton therapy process; a data processing module 103, which is connected to the data acquisition module 102 and is used to obtain the first information deviation between the actual patient status information and the theoretical patient status information and the second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; a real-time feedback module 104, which is connected to the data processing module 103 and the online diagnosis and treatment module 101, and is used to send the first information deviation and the second information deviation to the online diagnosis and treatment module 101, so that the online diagnosis and treatment module 101 adjusts the patient's positioning according to the first information deviation, and updates the preset treatment plan according to the second information deviation and the current treatment plan after the completion of the current patient proton therapy. Through this system, when the online diagnosis and treatment module 101 performs patient proton therapy, treatment can be carried out according to the pre-obtained theoretical patient status information, thereby avoiding the influence of the changes caused by the malignant growth of the tumor during the process of image acquisition and treatment on the effect of proton therapy.

[0037] In some embodiments of the present invention, the data acquisition module 102 includes: an X-ray image acquisition device, which is used to acquire patient images using X-rays and use the acquired X-ray images as the actual patient status information.

[0038] Specifically, after the patient lies on the treatment couch, the treatment couch will be moved to the preset treatment position in the current treatment plan, and the two-dimensional image of the patient is acquired by the X-ray image acquisition device or the two-dimensional image is reconstructed into a three-dimensional image, and the obtained two-dimensional image or three-dimensional image is used as the actual patient status information.

[0039] Register the actual patient status information with the theoretical patient status information to obtain the setup error between the actual treatment position and the preset treatment position of the patient. This setup error is the first information deviation mentioned above. After obtaining this setup error, the patient setup can be adjusted according to this setup error. For example, if the setup error is not very large, the position of the treatment couch can be adjusted according to the setup error.

[0040] The beneficial effect of this stage is as follows: When the patient lies on the treatment couch, due to breathing, unstable body position or natural physiological changes, there will be a deviation from the position during the imaging acquisition before treatment. Even if these changes are very small, they may affect the treatment accuracy. Since the range and energy release of the proton beam are very precise, any small deviation may result in incomplete irradiation of the tumor or additional radiation to healthy tissues. By image registration, the current setup error is obtained. If the error is within the set error threshold range, the setup error can be sent to the treatment couch to control the precise movement of the treatment couch, so that the patient reaches the true treatment position for proton therapy, improving the treatment accuracy and ensuring that the proton beam can accurately irradiate the tumor area during each treatment. If the setup deviation exceeds the error threshold, it is considered that the initial setup deviation of the patient is too large, and the patient needs to be repositioned using the positioning device, and then X-ray images are acquired for image registration until the setup error meets the requirements.

[0041] In some embodiments of the present invention, the online diagnosis and treatment module 101 includes a proton therapy device for emitting a proton beam to the patient for proton therapy of the patient.

[0042] For proton therapy, the range of protons is usually calculated using Monte Carlo simulation and fast calculation models. However, the range calculated using the model is only a theoretical value. During the treatment process, the uncertainty of the range of the beam in the patient's body causes a deviation between the actual range of the proton and the theoretical value, which will affect the efficacy of proton therapy.

[0043] Therefore, to solve the above problems existing in proton therapy, the data acquisition module 102 is further provided with: a range information acquisition device for acquiring the rays generated when the proton beam irradiates the patient, obtaining the actual range of the proton beam according to the rays, and using the actual range as the actual treatment parameter information.

[0044] Among them, the above range information acquisition device can adopt a PET (Positron Emission Tomography) detection device. For example, a dual-panel digital PET detection system can be adopted.

[0045] Specifically, when the proton beam irradiates the tumor target area, a nuclear reaction occurs between the proton beam and the tumor tissue, generating a positron nuclide and releasing a pair of gamma rays. The gamma ray signals are collected by the dual-plate digital PET detection system and reconstructed to obtain the actual range of the proton beam in the tumor target area.

[0046] The beneficial effect of this stage is that the range of the proton beam in the tumor target area is uncertain. The range in this treatment plan is calculated based on a model, resulting in the inability to verify the actual range of the proton beam in the tumor target area. Therefore, it is impossible to ensure that the proton beam irradiates accurately according to the range in this treatment plan. If there is a deviation, it may lead to incomplete irradiation of the tumor or additional radiation to healthy tissues, failing to achieve the best treatment effect of proton therapy. By obtaining the actual range of the proton beam in the tumor target area in real time, on the one hand, it can be cross-validated with the theoretical range value to improve the model calculation algorithm and enhance the accuracy of model calculation. On the other hand, it can evaluate the treatment effect online, and it is possible to see in real time the situation of the proton beam irradiating the tumor area, whether it fully covers the tumor area or only partially covers it, and adjust the subsequent fractionated treatment plan as needed.

[0047] Moreover, the above actual range can be compared with the preset value (theoretical treatment parameter information) in this treatment plan to update the preset treatment plan according to the deviation of this second information. For example, the deviation of this second information can be displayed to provide it to medical staff for online diagnostic treatment.

[0048] The beneficial effect of this stage is that by comparing the actual range of the proton beam with the theoretical value of this treatment plan to obtain a deviation value, if the deviation value is greater than the set range threshold, an alarm prompt message will pop up on the online platform to guide medical staff for online diagnostic evaluation. If the proton beam irradiates normal tissues outside the tumor target area, it is recommended that medical staff take necessary measures to reduce the damage to the patient's normal tissues and reduce the treatment risk. If it can continue to be treated according to this treatment plan after evaluation, the subsequent fractionated treatment plan can be adjusted to make up for the deficiencies of this treatment and improve the effect of proton therapy.

[0049] In some embodiments of the present invention, the above theoretical patient status information can be the patient's simulated CT image. That is to say, it can be set that the data acquisition module 102 further includes: a simulated CT device for acquiring the patient's simulated CT image and using the patient's simulated CT image as the theoretical patient status information.

[0050] Specifically, the simulated CT device is used to acquire the patient's simulated CT image and transmit it to the online platform. Medical staff evaluate the tumor structure of the patient, outline the tumor target area on the simulated CT image, and formulate this treatment plan, including parameters such as the irradiation angle, irradiation depth, and dose distribution of the proton beam, to formulate a treatment plan for the patient.

[0051] The beneficial effects of this stage are as follows: During the treatment period, the position and shape of the patient's tumor will show uncertain changes. By collecting the latest simulation CT image before treatment, medical staff can redraw the tumor target area, accurately adjust the current treatment plan, formulate personalized treatment plans for each patient, enable more accurate and effective proton therapy, and improve the treatment effect. At the same time, by obtaining the latest information on the size and position of the tumor through the simulation CT image, the accuracy of image registration can be improved when registering images before the patient's treatment, ensuring that the patient is accurately moved to the treatment position and improving the accuracy of treatment.

[0052] Furthermore, after obtaining the above two-dimensional or three-dimensional image, the two-dimensional or three-dimensional image can be registered with the simulation CT image, so that the data processing module 103 obtains the information deviation between the above two-dimensional or three-dimensional image and the above simulation CT image. This information deviation is the above first information deviation, and the patient's positioning can be adjusted according to this first information deviation, and then a proton beam can be emitted to the patient after the positioning is adjusted.

[0053] In some embodiments of the present invention, the data processing module 103 is further configured to: after the online diagnosis and treatment module 101 completes the treatment of the patient, update the preset treatment plan according to all the second information deviations obtained during the treatment process of the patient by the online diagnosis and treatment module 101.

[0054] Specifically, the online platform will collect and process all the range information deviations (i.e., the above second information deviations) generated during the patient's multiple proton therapy processes. Medical staff will optimize the subsequent treatment plan according to the feedback data and the actual treatment situation.

[0055] The beneficial effects of this stage are as follows: If the proton beam irradiates normal tissues outside the tumor target area or fails to completely cover the tumor target area during proton therapy, the subsequent treatment plan will be adjusted according to the actual situation, including adjusting parameters such as the irradiation angle, irradiation depth, and dose distribution of the proton beam, to ensure that the patient obtains the maximum therapeutic effect in subsequent treatments.

[0056] In some embodiments of the present invention, the patient's theoretical state information is the information collected within 24 hours before the patient's proton therapy this time.

[0057] The following will be described with a specific embodiment.

[0058] In the pre-treatment stage, patient image acquisition and treatment plan evaluation are divided into three steps.

[0059] The first step is to collect the patient's simulation CT image. Use the simulation CT device to collect the patient's simulation CT image and obtain detailed three-dimensional image data of the patient's tumor target area, including the position, size, shape of the tumor and its relationship with the surrounding normal tissues.

[0060] In the second step, the images are transmitted to the online platform. The simulated CT images of the patient are transmitted to the online platform through the medical information system. The online platform evaluates the changes in the tumor and surrounding normal tissues through an automated algorithm, and combines the historical data with the historical treatment plans to conduct a preliminary evaluation of the treatment plan.

[0061] In the third step, the treatment plan is adjusted online: Based on the image evaluation, medical staff can accurately outline the contour of the tumor, adjust the treatment plan, and obtain the final treatment plan for this treatment to be put into use. The adjusted content may include parameters such as the irradiation angle, irradiation depth, and dose distribution of the proton beam. After the generation of this treatment plan, the treatment position and plan of the patient will be saved on the online platform for use in subsequent treatment stages.

[0062] In the patient positioning stage, image registration and precise positioning are carried out in two steps.

[0063] In the first step, patient positioning: After the patient lies on the treatment couch, the treatment couch is first moved to the treatment position according to this treatment plan, and the laser is aligned with the tumor target point of the patient. Here, the target point is a marked point drawn on the skin at the tumor position of the patient or on the thermoplastic mold used to fix the patient. Using the laser to align with the target point allows medical staff to quickly adjust the patient's body position and place the tumor target area in the correct position in the treatment area.

[0064] In the second step, obtaining the setup error: The two-dimensional image of the patient is collected through the X-ray image acquisition device or the two-dimensional image is reconstructed into a three-dimensional image, and the two-dimensional or three-dimensional image is registered with the simulated CT image to obtain the setup error. This setup error is the first information deviation between the actual patient state information and the theoretical patient state information.

[0065] If the setup error is within the set error threshold range, the setup error can be sent to the treatment couch. The treatment couch applies the six-axis coordinates in the setup error, including translation in three degrees of freedom of up and down, left and right, front and back, and rotation in three degrees of freedom of pitch, yaw, and roll, and moves the treatment couch to change the actual treatment position of the patient.

[0066] If the setup error exceeds the set error threshold, it indicates that there is a deviation during the setup or the patient moves during the process of collecting the X-ray image. Then, medical staff needs to reposition the patient, adjust the patient's body position and posture, collect the X-ray image again, and perform image registration to obtain the setup error until the setup error is within the error threshold range, completing the precise positioning of the tumor target area before the patient's treatment.

[0067] In the data acquisition stage, proton beam irradiation and real-time feedback are carried out in three steps.

[0068] Step 1, Proton beam irradiation: After confirming the accurate positioning of the patient, proton therapy begins, and the proton beam is irradiated to the tumor target area according to the pre-designed plan.

[0069] Step 2, Positron nuclide detection: After the proton beam penetrates the tumor target area, it interacts with the tumor tissue to generate a nuclear reaction, releasing positrons and producing a pair of gamma rays. These gamma rays are collected in real time by the PET detection device and converted into the actual range data of the proton beam.

[0070] Step 3, Feedback and real-time data processing: By reconstructing the activity distribution of the PET detection signal, the system calculates the actual range of the proton beam in real time and feeds the result back to the online platform. The online platform compares the calculated range with the preset value in the current treatment plan to generate a deviation report, which is the information deviation between the actual treatment parameter information and the theoretical treatment parameter information.

[0071] In the treatment evaluation stage, the comparison of the actual range with the plan and feedback adjustment are carried out in three steps.

[0072] Step 1, Deviation value evaluation: Compare the actual range of the proton beam with the preset value in the current treatment plan to judge the difference between the two. If the difference exceeds the set tolerance range, the treatment deviation value is automatically calculated and the information deviation is fed back to the online platform.

[0073] Step 2, Real-time feedback and evaluation: The deviation between the preset range and the actual range in the current treatment plan is fed back to the medical staff in real time, and the medical staff can evaluate whether subsequent treatment plan adjustments are needed based on the real-time feedback information.

[0074] Step 3, Treatment plan adjustment: If there is a significant deviation, the medical staff can, with the help of the online platform, adjust the plan for subsequent treatment fractions, including adjusting parameters such as the range, dose distribution, and irradiation angle, to ensure that the proton beam can irradiate the tumor target area more precisely.

[0075] In the post-treatment stage, the adjustment and optimization of the subsequent treatment fractions are carried out in two steps.

[0076] Step 1, Collection and analysis of information deviation: After each treatment, all the range information deviations generated during the treatment process are collected and stored in the online platform. These data will serve as the basis for subsequent treatment adjustments.

[0077] Step 2, Adjust the treatment plan for subsequent fractions: The medical staff analyzes the accuracy of the current treatment plan based on the information deviation during the treatment process and adjusts the subsequent treatment plan. The adjustment of the treatment plan can include re-evaluating the position of the treatment target area, adjusting parameters such as the irradiation angle, irradiation depth, and dose distribution of the proton beam, to ensure that the patient achieves the maximum therapeutic effect in subsequent treatments.

[0078] It can be seen that the above adjustment mechanism is a continuous feedback loop. By obtaining the information deviation of the patient in each treatment in real time, the treatment plan is optimized, making each subsequent treatment more accurate, thereby improving the treatment effect and reducing side effects.

[0079] In summary, the integrated proton therapy system based on online diagnosis and treatment according to the embodiments of the present invention includes: an online diagnosis and treatment module for obtaining theoretical patient status information in advance, obtaining the current treatment plan according to the theoretical patient status information and the preset treatment plan, and performing proton therapy on the current patient according to the current treatment plan; a data acquisition module for collecting actual patient status information and actual treatment parameter information; a data processing module connected to the data acquisition module for obtaining a first information deviation between the actual patient status information and the theoretical patient status information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; a real-time feedback module connected to the data processing module and the online diagnosis and treatment module for sending the first information deviation and the second information deviation to the online diagnosis and treatment module, so that the online diagnosis and treatment module adjusts the patient positioning according to the first information deviation, and updates the preset treatment plan according to the second information deviation and the current treatment plan after completing the proton therapy on the current patient. Through this system, when performing proton therapy on a patient in the online diagnosis module, treatment can be carried out according to the pre-obtained theoretical patient status information, thereby avoiding the influence of changes caused by the malignant growth of tumors during the process of image acquisition and treatment on the effect of proton therapy.

[0080] Furthermore, the present invention proposes an integrated proton therapy method based on online diagnosis and treatment.

[0081] Figure 2 It is a flowchart of the integrated proton therapy method based on online diagnosis and treatment according to the embodiments of the present invention.

[0082] As Figure 2 shown, the integrated proton therapy method based on online diagnosis and treatment includes:

[0083] S21, obtaining theoretical patient status information in advance, and obtaining the current treatment plan according to the theoretical patient status information and the preset treatment plan.

[0084] S22, performing proton therapy on the current patient according to the current treatment plan, and collecting actual patient status information and actual treatment parameter information.

[0085] S23, obtaining a first information deviation between the actual patient status information and the theoretical patient status information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information.

[0086] S24. Adjust the patient's positioning according to the first information deviation, and update the preset treatment plan according to the second information deviation and the current treatment plan after completing the current proton therapy for the patient.

[0087] In an embodiment of the present invention, the theoretical patient status information is the information collected within 24 hours before the current proton therapy for the patient.

[0088] In an embodiment of the present invention, the actual patient status information includes X-ray images, the actual treatment parameter information includes the actual range, and the theoretical patient status information includes the patient's simulated CT images; wherein, the X-ray images are the images obtained by collecting the patient's images using X-rays, the actual range is the actual range of the proton beam obtained based on the positron nuclide generated when the proton beam irradiates the patient, and the patient's simulated CT images are the images obtained by using a simulated CT device for collection.

[0089] It should be noted that for other specific implementation manners of the integrated proton therapy method based on online diagnosis and treatment in the embodiments of the present invention, reference can be made to the integrated proton therapy system based on online diagnosis and treatment in the above embodiments.

[0090] The integrated proton therapy method based on online diagnosis and treatment in the embodiments of the present invention can achieve that when the patient undergoes proton therapy in the online diagnosis module, the treatment is carried out according to the pre-obtained theoretical patient status information, thereby avoiding the influence of the changes caused by the malignant growth of the tumor during the process of image acquisition and treatment on the effect of proton therapy.

[0091] Furthermore, the present invention proposes an electronic device.

[0092] As Figure 3 shown, the electronic device 500 includes: a processor 501 and a memory 503. Among them, the processor 501 and the memory 503 are connected, such as through a bus 502. Optionally, the electronic device 500 may further include a transceiver 504. It should be noted that in actual applications, the transceiver 504 is not limited to one, and the structure of the electronic device 500 does not constitute a limitation to the embodiments of the present invention.

[0093] The processor 501 can be a CPU (Central Processing Unit), a general-purpose processor, a DSP (Digital Signal Processor), an ASIC (Application Specific Integrated Circuit), an FPGA (Field Programmable Gate Array), or other programmable logic devices, transistor logic devices, hardware components, or any combination thereof. It can implement or execute various exemplary logical blocks, modules, and circuits described in connection with the disclosure of the present invention. The processor 501 can also be a combination that implements computing functions, such as a combination of one or more microprocessors, a combination of a DSP and a microprocessor, etc.

[0094] The bus 502 can include a path for transmitting information between the above components. The bus 502 can be a PCI (Peripheral Component Interconnect) bus, an EISA (Extended Industry Standard Architecture) bus, or the like. The bus 502 can be divided into an address bus, a data bus, a control bus, etc. For ease of representation, Figure 3 only a thick line is shown herein, but it does not mean that there is only one bus or one type of bus.

[0095] The memory 503 is used to store a computer program corresponding to the integrated proton therapy method based on online diagnosis and treatment of the above embodiments of the present invention, and the computer program is controlled and executed by the processor 501. The processor 501 is used to execute the computer program stored in the memory 503 to implement the content shown in the foregoing method embodiments.

[0096] Among them, Figure 3 the illustrated electronic device 500 is only an example and should not impose any limitation on the functions and usage scope of the embodiments of the present invention.

[0097] The electronic device of the embodiments of the present invention, by implementing the integrated proton therapy method based on online diagnosis and treatment of the above embodiments, can perform treatment according to the pre-obtained theoretical patient status information when the patient's proton therapy is performed in the online diagnosis module, thereby avoiding the influence of the changes caused by the malignant growth of the tumor during the process of image acquisition and treatment on the effect of proton therapy.

[0098] It should be noted that the logic and / or steps represented in the flowchart or otherwise described herein can be considered as a definite sequence of executable instructions for implementing logical functions, which can be specifically implemented in any computer-readable medium for use by an instruction execution system, apparatus or device (such as a computer-based system, a system including a processor, or other systems that can fetch instructions from the instruction execution system, apparatus or device and execute the instructions), or in combination with these instruction execution systems, apparatuses or devices. For the purposes of this specification, a "computer-readable medium" can be any device that can contain, store, communicate, propagate or transport a program for use by or in combination with an instruction execution system, apparatus or device. More specific examples (non-exhaustive list) of the computer-readable medium include the following: an electrical connection portion with one or more wirings (electronic device), a portable computer diskette (magnetic device), a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium can even be paper or other suitable medium on which the program can be printed, because the program can be obtained electronically, for example, by optically scanning the paper or other medium, followed by editing, interpretation or, if necessary, other suitable processing, and then stored in a computer memory.

[0099] It should be understood that the various parts of the present invention can be implemented by hardware, software, firmware or a combination thereof. In the above-described embodiments, multiple steps or methods can be implemented by software or firmware stored in a memory and executed by a suitable instruction execution system. If implemented in hardware, as in another embodiment, any one or a combination of the following techniques well known in the art can be used: discrete logic circuits having logic gate circuits for implementing logical functions on data signals, application specific integrated circuits having appropriate combinational logic gate circuits, programmable gate arrays (PGAs), field programmable gate arrays (FPGAs), etc.

[0100] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples", etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0101] In the description of this specification, the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. is based on the orientation or positional relationship shown in the drawings, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and should not be construed as a limitation on the present invention.

[0102] In addition, the terms "first" and "second" are used only for descriptive purposes and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In the description of the present invention, the meaning of "a plurality" is at least two, such as two, three, etc., unless otherwise specifically defined.

[0103] In the description of this specification, unless otherwise stated, the terms "mounted", "connected", "coupled", "fixed", etc. should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or integrated; it may be a mechanical connection or an electrical connection; it may be directly connected or indirectly connected through an intermediate medium, and it may be the internal communication of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0104] In the present invention, unless otherwise clearly specified and limited, the first feature being "on" or "under" the second feature may be that the first and second features are in direct contact, or the first and second features are indirectly in contact through an intermediate medium. Moreover, the first feature being "above", "over" and "on top of" the second feature may be that the first feature is directly above or obliquely above the second feature, or merely indicates that the first feature has a higher horizontal height than the second feature. The first feature being "under", "beneath" and "underneath" the second feature may be that the first feature is directly below or obliquely below the second feature, or merely indicates that the first feature has a lower horizontal height than the second feature.

[0105] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as a limitation on the present invention. Those of ordinary skill in the art can make changes, modifications, substitutions, and variations to the above embodiments within the scope of the present invention.

Claims

1. An integrated proton therapy system based on online diagnosis and treatment, characterized in that The system includes: An online diagnosis and treatment module, configured to obtain theoretical patient status information in advance, obtain the current treatment plan according to the theoretical patient status information and a preset treatment plan, and perform proton treatment on the current patient according to the current treatment plan; A data acquisition module, configured to acquire actual patient status information and actual treatment parameter information; A data processing module, connected to the data acquisition module, configured to obtain a first information deviation between the actual patient status information and the theoretical patient status information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; A real-time feedback module, connected to the data processing module and the online diagnosis and treatment module, configured to send the first information deviation and the second information deviation to the online diagnosis and treatment module, so that the online diagnosis and treatment module adjusts the patient positioning according to the first information deviation, and updates the preset treatment plan according to the second information deviation and the current treatment plan after completing the proton treatment on the current patient.

2. The integrated proton therapy system based on online diagnosis and treatment according to claim 1, characterized in that, The data acquisition module includes: An X-ray image acquisition device, configured to acquire patient images using X-rays and use the acquired X-ray images as the actual patient status information.

3. The integrated proton therapy system based on online diagnosis and treatment according to claim 1, wherein The online diagnosis and treatment module includes a proton treatment device for emitting a proton beam to the patient to perform proton treatment on the patient. The data acquisition module further includes: A range information acquisition device, configured to acquire the rays generated when the proton beam irradiates the patient, obtain the actual range of the proton beam according to the rays, and use the actual range as the actual treatment parameter information.

4. The integrated proton therapy system based on online diagnosis and treatment according to claim 1, wherein The data acquisition module further includes: A simulated CT device, configured to acquire simulated CT images of the patient and use the simulated CT images of the patient as the theoretical patient status information.

5. The integrated proton therapy system based on online diagnosis and treatment according to claim 1, characterized in that The data processing module is further configured to: After the online diagnosis and treatment module completes the proton treatment on the patient, update the preset treatment plan according to all the second information deviations obtained during the process of the online diagnosis and treatment module performing proton treatment on the patient.

6. The integrated proton therapy system based on online diagnosis and treatment according to claim 1, characterized in that The theoretical patient status information is the information acquired within 24 hours before the current proton treatment on the patient.

7. An integrated proton therapy method based on online diagnosis and treatment, characterized in that, The method includes: Obtaining theoretical patient status information in advance, and obtaining the current treatment plan according to the theoretical patient status information and a preset treatment plan; Performing proton treatment on the current patient according to the current treatment plan, and acquiring actual patient status information and actual treatment parameter information; Obtaining a first information deviation between the actual patient status information and the theoretical patient status information and a second information deviation between the actual treatment parameter information and the theoretical treatment parameter information; Adjusting the patient positioning according to the first information deviation, and updating the preset treatment plan according to the second information deviation and the current treatment plan after completing the proton treatment on the current patient.

8. The integrated proton therapy method based on online diagnosis and treatment according to claim 7, characterized in that, The theoretical patient status information is the information acquired within 24 hours before the current proton treatment on the patient.

9. The integrated proton therapy method based on online diagnosis and treatment according to claim 7, wherein The actual patient status information includes X-ray images, the actual treatment parameter information includes the actual range, and the theoretical patient status information includes simulated CT images of the patient; wherein, the X-ray images are images obtained by collecting patient images using X-rays, the actual range is the actual range of the proton beam obtained based on the positron nuclide generated when the proton beam irradiates the patient, and the simulated CT images of the patient are images obtained by using a simulated CT device for collection.

10. An electronic device, characterized in that, It includes a memory, a processor, and a computer program stored on the memory and running on the processor. When the computer program is executed by the processor, it implements the integrated proton therapy method based on online diagnosis and treatment according to any one of claims 7-9.

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