Animal fixing device, fixator and radiation dose real-time regulation and control method

Abstract

The invention provides an animal fixing device, an animal fixing apparatus and a radiation dose real-time regulation and control method, and solves the problems that a fixing device in the prior art is difficult to conveniently and accurately regulate and control the radiation dose, and more difficult to conveniently and accurately regulate and control the radiation dose on line in real time; the technical problems of complex operation, low efficiency and low accuracy of radiation dose regulation and control are solved. The animal fixing device comprises a box body and a radiation adjusting assembly, and an opening is formed in the top of the box body; the radiation adjusting assembly comprises a shielding plate, the shielding plate can shield radiation, and the shielding plate is in sliding connection with the top of the box body; a gap is formed between one end of the shielding plate and the top of the side wall of the box body; a pull rod is fixed at one end, far away from the gap, of the shielding plate, and scales are arranged on the pull rod; after the animal fixing device is fixed in the fixator, the pull rod extends out of the fixator from the interior of the fixator.

Description

Technical Field

[0001] The present invention relates to the field of neutron therapy animal experiments, and particularly relates to an animal fixing device, a fixator, and a method for real-time regulation of radiation dose. Background Art

[0002] In neutron therapy animal experiments, a neutron beam is used to irradiate the target position of an experimental animal to obtain the experimental results of the influence of the neutron beam on the target. During the experiment, there are many types of animal irradiation fixing devices, which have initially taken shape, but still expose some shortcomings and deficiencies. The existing technologies for fixing animals mainly include two types of devices. The first is a single-animal fixing device. Although it achieves the fixing effect, its limitation is that it cannot conduct batch experiments, reducing the experimental efficiency and unable to ensure that the irradiation doses of different batches of animals are exactly the same. The second is a multi-animal juxtaposed fixing device, which can simultaneously fix multiple fixing devices on the fixing disk surface. Although it achieves the purpose of batch experiments to a certain extent, due to the distance difference between the animals and the neutron beam, it is difficult to ensure the uniformity and consistency of the radiation dose.

[0003] Moreover, the existing fixing devices have many deficiencies. Experimental animals are usually fixed on a limit plate, and a shielding plate is arranged on the side facing the neutron beam. The shielding plate and the limit plate are connected by a plurality of bolts. An irradiation hole is arranged on the shielding plate for the neutron beam to pass through to irradiate the experimental animal. Due to the existence of the shielding plate, other places will not be irradiated by the neutron beam.

[0004] Due to the continuous update of experimental methods, there is currently a need to adjust the radiation dose in real time during the experiment. However, since the shielding cover arranged on the fixing device is fixed, when adjusting the radiation dose of the experimental animal, it is necessary to replace the shielding cover with different sizes of irradiation holes or adjust the parameters of the neutron beam. Adjusting the parameters of the neutron beam involves the regulation of many module parameters, and the regulation process is cumbersome and complex, and it cannot be guaranteed that the desired radiation dose can be achieved; if the shielding cover is selected to be replaced, it is necessary to stop the machine and disassemble all the fixing devices, and then install the bolts and start the machine in sequence. For the multi-animal juxtaposed fixing device, each fixing device needs to be fixed to the fixing disk by bolts, the workload is huge, and the disassembly and assembly processes are all manual operations, and the quality of disassembly and assembly is difficult to guarantee.

[0005] Therefore, it is difficult to achieve convenient and accurate regulation of the radiation dose, and it is even more difficult to achieve convenient and accurate real-time online regulation of the radiation dose, resulting in technical problems such as complex operation, low efficiency, and low accuracy of radiation dose regulation.

[0006] Therefore, it is necessary to improve the fixing device for fixing experimental animals during neutron therapy, so as to achieve convenient and accurate regulation of radiation dose in real time during the experiment. Summary of the Invention

[0007] The object of the present invention is to provide an animal fixing device, a fixator and a method for real-time regulation of radiation dose, so as to solve the problem that the shielding cover of the existing fixing device is difficult to move. When adjusting the radiation dose of experimental animals, it is necessary to replace the shielding cover with different-sized openings or adjust the parameters of the neutron beam. Adjusting the parameters of the neutron beam involves the regulation of many module parameters, and the regulation process is cumbersome and complex, and it cannot be guaranteed that the desired radiation dose can be achieved; replacing the shielding cover requires shutting down the machine, disassembling all fixing devices, then installing and starting up one by one. Therefore, it is difficult to achieve convenient and accurate regulation of radiation dose, and it is even more difficult to achieve real-time online regulation, resulting in complex operation, low efficiency, and low accuracy of radiation dose regulation.

[0008] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0009] In the first aspect, the present invention provides an animal fixing device for being fixed in a fixator, including a box body and a radiation adjustment component. The box body is used to fix the body of an experimental animal, and the top of the box body has an opening;

[0010] The radiation adjustment component includes a shielding plate that can shield radiation, and the shielding plate is slidably connected to the top of the box body;

[0011] There is a gap between one end of the shielding plate and the top of the side wall of the box body;

[0012] When the shielding plate slides on the top of the box body, the opening degree of the gap can increase or decrease;

[0013] A pull rod is fixed to the end of the shielding plate away from the gap. A scale is provided on the pull rod. The pull rod is used to adjust the position of the shielding plate during radiation exposure, and the scale is used to mark the position of the shielding plate;

[0014] After the animal fixing device is fixed in the fixator, the pull rod extends from the inside of the fixator to the outside of the fixator.

[0015] During implementation, the neutron beam can irradiate the corresponding part of the body of the experimental animal in the box through the gap, while other parts are shielded by the shielding plate and the neutron beam will not irradiate other parts of the experimental animal. Since the shielding plate can slide, the opening degree of the gap can be adjusted, and thus the irradiation dose can be adjusted. The specific increment or decrement of the irradiated dose can be achieved through the pull rod and the scale on it. After the animal fixing device is fixed to the fixator, the pull rod extends outside the fixator. Then, during the radiation irradiation process, the opening degree of the gap can be adjusted in real time without disassembling the fixator or the animal fixing device, realizing the online adjustment of the radiation dose, providing an intuitive dose control means for the experimental personnel, and thus improving the accuracy and reliability of the experiment.

[0016] Preferably, the third mapping relationship between the scale value of the scale and the radiation dose is used to adjust the radiation dose by adjusting the scale value:

[0017] D B =(Ф0 - λA0 / (kL))tσ B N B κ B RBE;

[0018] Wherein, Ф0 is the thermal neutron flux density at beam output, λ is a confidential constant, A0 is the initial area of the beam current at beam output, k is the area coefficient, L is the scale value, t is the irradiation time, σ B neutron therapy capture cross section, N B boron concentration in the tumor, κ B dose conversion coefficient, RBE is the relative biological effectiveness coefficient.

[0019] Preferably, the box body includes a bottom plate, and a fixing plate is slidably connected near the bottom plate. The fixing plate is provided with a strap, and both ends of the strap respectively pass through the fixing plate and extend to one side of the bottom plate. Both ends of the strap are respectively fixed to an adjusting knob, and the adjusting knob can adjust the tightness of the strap.

[0020] Traditional fixing methods may cause unstable fixing due to differences in animal body sizes, affecting the experimental results. The technical solution of this embodiment can make the strap closely fit the animal's body shape by adjusting the number of turns of the adjusting knob. This design improves the flexibility and applicability of the fixing device, can adapt to animals of different body sizes, and avoids experimental errors caused by animal movement, thus enhancing the diversity and accuracy of the experiment.

[0021] Preferably, at the position of the fixing plate corresponding to the gap, a head holder is provided for holding the head of the experimental animal.

[0022] Preferably, one side of the bottom plate has an inclined portion extending outwardly and obliquely, and there is an included angle between the plane where the inclined portion is located and the plane where the bottom plate is located, and the included angle is an obtuse angle; a head holder is provided on the inclined portion for holding the head of the experimental animal.

[0023] Preferably, the head holder includes a first clamping block and a second clamping block, the first clamping block and the second clamping block are respectively slidably connected to the fixing plate, and the head of the experimental animal is placed between the first clamping block and the second clamping block.

[0024] In this way, after fixing the experimental animal on the fixing plate, slide the first clamping block and the second clamping block away from each other, place the head of the experimental animal between the first clamping block and the second clamping block, and then slide the first clamping block and the second clamping block towards each other to fix the head of the experimental animal at a preset position to avoid head displacement during irradiation.

[0025] Preferably, a first side plate extends upward from one side of the bottom plate, and a second side plate extends upward from the other side of the bottom plate;

[0026] First upper sliding grooves and second upper sliding grooves are respectively provided at the tops of the first side plate and the second side plate;

[0027] Two sides of the shielding plate are respectively slidably connected in the first upper sliding groove and the second upper sliding groove;

[0028] First lower sliding grooves and second lower sliding grooves are respectively provided at positions of the first side plate and the second side plate close to the bottom plate;

[0029] Two sides of the fixing plate are respectively slidably connected in the first lower sliding groove and the second lower sliding groove.

[0030] In a second aspect, the present invention provides a fixing device, including a fixing disk and a shielding disk, and a plurality of the above-mentioned animal fixing devices are fixed on the fixing disk;

[0031] Each of the animal fixing devices is evenly distributed radially along a circumference with the center of the fixing disk as the center of the circle;

[0032] One end of the box body of each of the animal fixing devices away from the pull rod is a tip, and one end of the corresponding bottom plate has an acute-angled triangular end;

[0033] After each of the animal fixing devices is fixed on the fixing disk, the tips of each of the box bodies can be joined on the central axis of the fixing disk; each of the pull rods extends from the inside of the fixing device to the outside of the fixing device;

[0034] The outer peripheral side of the shielding disk is detachably connected to the outer peripheral side of the fixing disk, and each of the animal fixing devices is located between the shielding disk and the fixing disk.

[0035] During implementation, the neutron beam can pass through the fixed disk and irradiate the corresponding part of the body of the experimental animal in the box through the gap on the animal fixing device. For other parts, due to the shielding plate, radiation can be shielded, and the neutron beam will not irradiate other parts of the experimental animal. Since the shielding plate can slide, the opening degree of the gap can be adjusted, and thus the irradiation dose can be adjusted. The specific increase or decrease in the irradiated dose can be achieved through the pull rod and the scale on it. After the animal fixing device is fixed to the fixator, the pull rod extends outside the fixator. Then, during the radiation irradiation process, the opening degree of the gap can be adjusted in real time without disassembling the fixator or the animal fixing device, realizing the online adjustment of the radiation dose.

[0036] In a third aspect, the present invention provides a method for real-time regulation and control of radiation dose, using the fixator equipped with the animal experiment device as described above, including the following steps:

[0037] S1. Obtain the target radiation dose;

[0038] S2. According to the third mapping relationship, obtain the target scale value;

[0039] S3. Pull each pull rod to make each pull rod reach the target scale position;

[0040] S4. Complete the real-time adjustment of the radiation dose.

[0041] The present invention has the following beneficial effects: The animal fixing device of the present invention has a shielding plate structure with adjustable position, and can be adjusted in real time and online by pulling the pull rod. Furthermore, the opening degree of the gap can be adjusted, and thus the irradiation dose can be adjusted. The specific increase or decrease in the irradiated dose can be achieved through the pull rod and the scale on it. After the animal fixing device is fixed to the fixator, the pull rod extends outside the fixator. Then, during the radiation irradiation process, the opening degree of the gap can be adjusted in real time without disassembling the fixator or the animal fixing device, realizing the online adjustment of the radiation dose, providing an intuitive dose control means for experimental personnel, thereby improving the accuracy and reliability of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] In order to make the purpose, technical solutions and advantages of the invention clearer, the present invention will be further described in detail below with reference to the drawings, where:

[0043] Figure 1 It is a schematic diagram of the structure of the fixed box in the prior art.

[0044] Figure 2 It is a schematic diagram of the structure of the fixator in the prior art.

[0045] Figure 3 It is a schematic diagram of the structure of the fixed disk in the prior art.

[0046] Figure 4 It is a schematic diagram of the structure of the shielding disk in the prior art.

[0047] Figure 5 It is a schematic diagram of the overall structure of the animal fixing device according to the embodiment of the present invention.

[0048] Figure 6 It is an exploded view of the structure of the animal fixing device according to the embodiment of the present invention.

[0049] Figure 7 It is a schematic diagram of the structure of the box body of the animal fixing device according to the embodiment of the present invention.

[0050] Figure 8 It is a schematic diagram of the top structure of the fixing plate of the animal fixing device according to the embodiment of the present invention.

[0051] Figure 9 It is a schematic diagram of the bottom structure of the fixing plate of the animal fixing device according to the embodiment of the present invention.

[0052] Figure 10 It is a schematic diagram of the optimized structure of the animal fixing device according to the embodiment of the present invention.

[0053] Figure 11 It is an exploded view of the optimized structure of the animal fixing device according to the embodiment of the present invention.

[0054] Figure 12 It is a rear view sketch of the overall structure of the fixer according to the embodiment of the present invention.

[0055] Figure 13 It is a schematic sketch of the internal structure of the fixer according to the embodiment of the present invention.

[0056] Explanation of reference numerals: 1. Radiation adjustment assembly; 11. Shielding plate; 111. Limiting part; 12. Pull rod; 121. Scale; 13. Operation part; 2. Box body; 21. Tilted part; 22. Bottom plate; 221. Slot; 23. First side plate; 231. First ventilation hole; 24. Second side plate; 241. Second ventilation hole; 25. First upper sliding groove; 26. Second upper sliding groove; 27. First lower sliding groove; 28. Second lower sliding groove; 3. Head gripper; 31. First slider; 32. Second slider; 33. Slideway; 4. Fixing plate; 41. Binding strap; 42. Adjusting knob; 5. Fixing box; 51. Upper limiting plate; 52. Lower limiting plate; 53. Ventilation hole; 54. Irradiation hole; 55. Stud; 6. Fixer; 61. Fixed disk; 62. Fixing position; 63. Shielding disk. Detailed implementation manners

[0057] To more clearly elaborate the purpose, technical solution, and advantages of the embodiments of the present invention, the following will, in conjunction with the accompanying drawings, provide a detailed and complete description of the technical solutions in the embodiments of the present invention. It should be noted that the same reference numerals and letters in the drawings represent similar components. Once a component is defined in one drawing, it will not be re-defined and explained in subsequent drawings.

[0058] Regarding the multi-animal juxtaposition fixing device mentioned in the background art, common specific structural examples are given here, such as Figure 1 and Figure 2 shown.

[0059] As Figure 1 , the fixing box 5 includes an upper limiting plate 51 and a lower limiting plate 52. Among them, the animal is fixed at the fixing position 62 between the upper limiting plate 51 and the lower limiting plate 52. The upper limiting plate 51 is a shielding material capable of shielding radiation. The upper limiting plate 51 is respectively provided with a ventilation hole 53 and an irradiation hole 54. The ventilation hole 53 is used for ventilation to ensure the survival state of the animal during the experiment. The irradiation hole 54 is used to allow radiation to pass through, so that the target part of the experimental animal can be irradiated by radiation to achieve the purpose of the experiment. In the prior art, the position of the irradiation hole 54 is fixed and is often located at the head position of the animal. A plurality of studs 55 are detachably fixed between the upper limiting plate 51 and the lower limiting plate 52. After each stud 55 is correctly installed, its position is fixed, and each stud 55 can only be disassembled or installed at a relatively fixed position. Each stud 55 is evenly or unevenly distributed on both sides of the fixing position 62. After each stud 55 is correctly installed, it can limit the position of the experimental animal from both sides of the body of the experimental animal respectively.

[0060] After assembling the fixing box 5 shown in Figure 1 , as Figures 2 to 4 shown, a plurality of the fixing boxes 5 are respectively fixed in the fixer 6. The fixer 6 has a disc-shaped fixing plate 61. The neutron beam can irradiate a circular area that is centered on the center point of the fixing plate 61 and radially diverges uniformly outward along a certain radius. It should be noted that this circular area does not completely cover the entire fixing plate 61, but only the circular area near the center of the fixing plate 61. The fixing plate 61 has a plurality of fixing positions 62 that are evenly distributed radially along the circumference. Each of the fixing boxes 5 is respectively fixed to the fixing position 62 by screws, and one end of each fixing box 5 having the irradiation hole 54 is located at a position corresponding to the circular area to ensure that the neutron beam can irradiate each experimental animal evenly.

[0061] There are often multiple influencing factors for experimental results. Therefore, when conducting experiments, it is often necessary to set up multiple experimental groups to study the effects of multiple influencing factors on experimental results from multiple dimensions. Among them, in the experiment on the effect of radiation dose on experimental animals, other influencing factors need to be set as non-variables, and only the radiation dose is used as a variable for the experiment. To reduce experimental errors, multiple control group experiments will be set up simultaneously, that is, multiple fixing boxes 5 need to be fixed on the fixing plate 61 at the same time.

[0062] Then, when using the fixing box 5 as shown in Figure 1 the position of the irradiation hole 54 on the same upper limit plate 51 is fixed, and the size is also fixed. It is difficult to adjust the radiation dose in real time during irradiation. If you want to study the effect of radiation dose on experimental animals, you need to indirectly achieve it by replacing the upper limit plate 51 with different-sized irradiation holes 54 or adjusting the parameters of the neutron beam. However, regulating the parameters of the neutron beam involves the regulation of many module parameters, and the regulation process is cumbersome and complex, and it cannot be guaranteed that the desired radiation dose can be achieved.

[0063] In practical applications, in order to prevent the neutron beam from passing through the fixing plate 61 and irradiating to other places, the fixer 6 also includes a shielding plate 63. The material of the shielding plate 63 is a shielding material. The shielding area of the shielding plate 63 is adapted to the area of the fixing plate 61. The edge of the shielding plate 63 is detachably connected to the edge of the fixing plate 61. If you want to adjust the size of the irradiation hole 54 by replacing the upper limit plate 51 corresponding to each fixing box 5, not only the fixing plate 61 and the shielding plate 63 need to be disassembled, but also each fixing box 5 on the fixing plate 61 needs to be disassembled one by one, and then each upper limit plate 51 needs to be disassembled one by one.

[0064] This process is cumbersome and time-consuming, greatly affecting the experimental efficiency. Since it involves live animal experiments, it is necessary to anesthetize each experimental animal in advance during the experiment. Therefore, it is also necessary to consider the waking state and waking degree of each experimental animal. If the disassembly and replacement time is too long, each experimental animal may enter the waking state at different time periods.

[0065] If it enters the waking state during irradiation, then it may struggle during irradiation, causing the animal's position to change, making it difficult to continue irradiating the target position, and even the experimental animal may escape from the fixing device, thus affecting the accuracy of the experimental results.

[0066] If it enters the waking state when accurately conducting the next experiment, then it needs to be anesthetized again, which not only increases the dosage of the anesthetic, but also may affect the physical state of the experimental animal itself, thus affecting the accuracy of the experimental results.

[0067] Based on the above background, the technical concept of the present invention is: how to set the structure of the fixing box so that the size of the irradiation hole can be adjusted in real time.

[0068] Then, based on the above technical concept, the following embodiments are provided. Each of the following embodiments can be applied to the animal fixing device, the integrated device and the radiation dose regulation in the process of neutron therapy animal experiments, and solves the problem that the shielding cover of the existing fixing device is difficult to move. When adjusting the radiation dose of the experimental animal, it is necessary to replace the shielding cover with different-sized openings or adjust the parameters of the neutron beam. However, the regulation of the parameters of the neutron beam involves the regulation of many module parameters, and the regulation process is cumbersome and complex, and it cannot be guaranteed that the desired radiation dose can be achieved; replacing the shielding cover requires shutting down and disassembling all the fixing devices, and then installing and powering on them in sequence. Therefore, it is difficult to achieve convenient and precise regulation of the radiation dose, and it is even more difficult to achieve convenient and precise regulation of the radiation dose in real time online, resulting in technical problems such as complex operation, low efficiency, and low accuracy of radiation dose regulation.

[0069] Embodiment 1. This embodiment provides an animal fixing device for being fixed in a fixator 6. Please refer to Figure 5 and Figure 6 , which includes a box body 2 and a radiation adjustment component 1. The box body 2 is used to fix the body of the experimental animal, and the top of the box body 2 has an opening;

[0070] The radiation adjustment component 1 includes a shielding plate 11, the shielding plate 11 can shield radiation, and the shielding plate 11 is slidably connected to the top of the box body 2;

[0071] There is a gap between one end of the shielding plate 11 and the top of the side wall of the box body 2;

[0072] When the shielding plate 11 slides on the top of the box body 2, the opening degree of the gap can increase or decrease;

[0073] A pull rod 12 is fixed to the end of the shielding plate 11 away from the gap. A scale 121 is provided on the pull rod 12. The pull rod 12 is used to adjust the position of the shielding plate 11 during radiation irradiation, and the scale 121 is used to mark the position of the shielding plate 11;

[0074] After the animal fixing device is fixed in the fixator 6, the pull rod 12 extends from the inside of the fixator 6 to the outside of the fixator 6.

[0075] During implementation, the neutron beam can radiate to the corresponding part of the body of the experimental animal in the box body 2 through the gap, while other parts are shielded from radiation by the shielding plate 11, and the neutron beam will not irradiate other parts of the experimental animal. Since the shielding plate 11 can slide, the opening degree of the gap can be adjusted, and thus the irradiation dose can be adjusted. The specific increment or decrement of the irradiated dose can be achieved through the pull rod 12 and the scale 121 thereon. After the animal fixing device is fixed to the fixator 6, the pull rod 12 extends outside the fixator 6. Then, during the radiation irradiation process, the opening degree of the gap can be adjusted in real time without disassembling the fixator 6 or the animal fixing device, realizing the on-line adjustment of the radiation dose, providing an intuitive dose control means for the experimenter, and thus improving the accuracy and reliability of the experiment.

[0076] Specifically, in Embodiment 1, an operation part 13 is provided at one end of the pull rod 12 away from the shielding plate 11, which is convenient for hand operation.

[0077] Specifically, the gap is located at positions corresponding to parts such as the head, chest, and limbs of the experimental animal. In actual application, it can be adjusted. The experimenter can select different types of shielding plates 11 according to actual needs to meet different irradiation requirements, improving the treatment flexibility.

[0078] Embodiment 2, based on Embodiment 1, there is a first mapping relationship between the scale value of the scale 121 and the area value of the gap, and a second mapping relationship between the area value of the gap and the radiation dose. By combining the first mapping relationship and the second mapping relationship, a third mapping relationship between the scale value of the scale 121 and the radiation dose is obtained. According to the third mapping relationship, by adjusting the scale value, the adjustment of the radiation dose is realized. Furthermore, by observing the scale value outside the fixator 6, the radiation dose at this time can be calculated according to the third mapping relationship, realizing the on-line and precise adjustment of the radiation dose. It should be noted that a fixed reference scale 121 line is provided at the outer edge of the fixator 6 to indicate the position of the scale 121, which is convenient for calculating the scale value.

[0079] Specifically, the first mapping relationship is as follows:

[0080] A r =kL (1)

[0081] where A r is the gap area, k is the area coefficient, and L is the scale value.

[0082] Specifically, the area coefficient k can be obtained through mathematical calculation or simulation.

[0083] The derivation process of the second mapping relationship is as follows:

[0084] D B = Фtσ B N B κ B RBE (2)

[0085] Wherein, D B is the radiation dose, t is the irradiation time, σ B is the neutron therapy capture cross-section, N B is the boron concentration in the tumor, κ B is the dose conversion coefficient, RBE is the relative biological effectiveness coefficient, and Ф is the thermal neutron flux density.

[0086] Specifically, the radiation dose refers to the dose of α particles and lithium nuclei generated by neutron therapy.

[0087] Wherein, the relationship between the thermal neutron flux density Ф and the gap area is:

[0088] Ф = Ф0 - λA0 / A r (3)

[0089] Wherein, Ф0 is the thermal neutron flux density at the beam output, λ is a confidential constant, A0 is the initial area of the beam current at the beam output, and A r is the gap area, that is, the exposed area.

[0090] Then, from equations (2) and (3), the second mapping relationship can be deduced, that is, the relationship between the radiation dose D B and the gap area A r is:

[0091] D B = (Ф0 - λA0 / A r )tσ B N B κ B RBE (4)

[0092] Furthermore, it can also be obtained that the relationship between the radiation dose and the scale value is:

[0093] D B = (Ф0 - λA0 / (kL))tσ B N B κ B RBE (5)

[0094] Wherein, Ф0 is the thermal neutron flux density at the beam output, λ is a confidential constant, A0 is the initial area of the beam current at the beam output, k is the area coefficient, L is the scale value, t is the irradiation time, σ B is the neutron therapy capture cross-section, N B is the boron concentration in the tumor, κ BDose conversion factor, RBE (relative biological effectiveness coefficient).

[0095] A fixing plate is installed inside the box body, and the body of the experimental animal is used to be fixed on the fixing plate.

[0096] Example 3, based on Example 1 or Example 2, please refer to Figures 6 to 9 , the box body 2 includes a bottom plate 22, and a fixing plate 4 is slidably connected near the position of the bottom plate 22. A binding strap 41 is arranged on the fixing plate 4. Two ends of the binding strap 41 respectively extend through the fixing plate 4 to one side of the bottom plate 22, and two ends of the binding strap 41 are respectively fixed to adjusting knobs 42, and the adjusting knobs 42 can adjust the tightness of the binding strap 41.

[0097] Traditional fixing methods may lead to unstable fixation due to differences in animal body sizes, affecting the experimental results. The technical solution of this embodiment can make the binding strap 41 closely fit the animal's body shape by adjusting the number of turns of the adjusting knob 42. This design improves the flexibility and applicability of the fixing device, can adapt to animals of different body sizes, avoids experimental errors caused by animal movement, and thus enhances the diversity and accuracy of the experiment.

[0098] Specifically, the material of the binding strap 41 is a flexible material, such as PU, leather, nylon, chemical fiber, cotton, linen, etc.

[0099] Specifically, please refer to Figure 7 and Figure 9 , a slot 221 is formed on the bottom plate 22. There are 3 adjusting knobs 42, and correspondingly 3 binding straps 41 are also provided. Each adjusting knob 42 can extend into the slot 221. The adjusting knobs 42 can limit the position of the fixing plate 4, prevent the position of the fixing plate 4 from changing during irradiation, and at the same time do not affect the disassembly of the fixing plate 4.

[0100] Example 4, based on Example 3, please refer to Figure 6 and Figure 8 , at the position of the fixing plate 4 corresponding to the gap, a head holder 3 is provided for clamping the head of the experimental animal.

[0101] Example 5, due to the structural limitations of the current neutron source, the neutron beam generally exits from the neutron source in the horizontal direction. Then, from Figure 2It can also be seen that the fixed disk 61 extends vertically, and the disk surface of the fixed disk 61 is perpendicular to the irradiation direction of the neutron beam. According to the current device, for several fixed boxes 5 fixed above the fixed disk 61 vertically, if their irradiation holes 54 need to be located at positions corresponding to the circular area, they need to be installed upside down. That is, after installation, the head of the experimental animal will face downward vertically. During the experiment, the experimental animal is in an inclined inverted or completely vertical position, which is likely to cause congestion in the head while compressing the respiratory system, making the animal prone to respiratory depression during anesthesia and stress after waking up, thus affecting the subsequent observation results, causing additional animal deaths, resulting in the lack of experimental group data of the set experimental factors, causing waste of the experiment, and may also affect the credibility of the experimental results.

[0102] Therefore, based on the above background, the technical problem that the present invention still needs to further solve is: how to further improve on the basis of Embodiments 1 to 3 to avoid the experimental animal having an inclined inverted or completely inverted position.

[0103] Based on the above solved technical problem, the following embodiments are given. The technical concept is: on the premise that the experimental animal has a soft body and each joint has an adjustable space, change the extending direction of the animal's head so that the extending direction of the head and the extending direction of the disk surface of the fixed disk 61 are not in the same spatial plane, but are distributed in different spatial planes, and there is an included angle between the extending directions.

[0104] Specifically, please refer to Figure 10 and Figure 11 , one side of the bottom plate 22 has an inclined portion 21 that extends obliquely outward. There is an included angle between the plane where the inclined portion 21 is located and the plane where the bottom plate 22 is located, and the included angle is an obtuse angle; a head holder 3 is provided on the inclined portion 21 for holding the head of the experimental animal.

[0105] In this way, after fixing the animal fixing device with such a structure on the fixed disk 61, for several animal fixing devices fixed above the fixed disk 61 vertically, the head of the experimental animal will not face downward vertically, changing the animal's position, making its head flat and the lower body elevated, thereby reducing the compression of the inverted position on the animal's respiratory system, not easily causing congestion in the head and stress, resulting in additional animal deaths, reducing the risk of asphyxia, greatly improving the comfort of the animal during the experiment, improving the comfort and survival quality of the animal during the experiment, making all the experimental group data of the set experimental factors valid, reducing the waste of the experiment, and improving the credibility of the experimental results. Moreover, this design does not need to add accessories, and solves the problem of accidental death of experimental animals caused by uncomfortable body positions in an economical and convenient way, and has good application prospects.

[0106] Specifically, the included angle preferably ranges from 120 to 150°, preferably 135° and 150°, which better conforms to the physiological curve of experimental animals.

[0107] Example 6, based on Example 4 or Example 5, please refer to Figure 8 , the head holder 3 includes a first clamping block and a second clamping block. The first clamping block and the second clamping block are respectively slidably connected to the fixing plate 4, and the head of the experimental animal is placed between the first clamping block and the second clamping block.

[0108] In this way, after fixing the experimental animal on the fixing plate 4, slide the first clamping block and the second clamping block away from each other, place the head of the experimental animal between the first clamping block and the second clamping block, and then slide the first clamping block and the second clamping block towards each other to fix the head of the experimental animal at a preset position, avoiding head displacement during irradiation.

[0109] Specifically, a slideway 33 is provided on the fixing plate 4, and the first clamping block and the second clamping block are respectively slidably connected to the slideway 33; the bottoms of the first clamping block and the second clamping block extend into the slideway 33, and damping members are respectively arranged between the two sides of the bottoms of the first clamping block and the second clamping block and the inner walls of the two sides of the slideway 33 to maintain the clamping force of the first clamping block and the second clamping block on the head of the experimental animal and reduce the possibility of displacement of the first clamping block and the second clamping block during irradiation.

[0110] Specifically, flexible pads are respectively fixed on the opposite sides of the first clamping block and the second clamping block to increase the comfort of the experimental animal. The flexible pad is preferably made of silica gel, which improves the fixing stability and ensures the comfort and safety of the animal during the experiment.

[0111] Example 7, based on Example 6, please refer to Figure 6 and Figure 7 , a first side plate 23 extends upward from one side of the bottom plate 22, and a second side plate 24 extends upward from the other side of the bottom plate 22; first upper slideways 25 and second upper slideways 26 are respectively arranged at the tops of the first side plate 23 and the second side plate 24; both sides of the shielding plate 11 are respectively slidably connected in the first upper slideway 25 and the second upper slideway 26; first lower slideways 27 and second lower slideways 28 are respectively arranged at positions of the first side plate 23 and the second side plate 24 close to the bottom plate 22; both sides of the fixing plate 4 are respectively slidably connected in the first lower slideway 27 and the second lower slideway 28.

[0112] Example 8, based on Example 1, please refer to Figure 12 and Figure 13, this embodiment provides a fixator 6, including a fixing disk 61 and a shielding disk 63. The fixing disk 61 is used to fix a plurality of the animal fixing devices. Each of the animal fixing devices is radially and evenly distributed along a circumference with the center of the fixing disk 61 as the center of the circle. One end of the box body 2 of each of the animal fixing devices, which is away from the pull rod 12, is a tip, and one end of the corresponding bottom plate 22 has an acute-angled triangular end. After each of the animal fixing devices is fixed to the fixing disk 61, the tips of each of the box bodies 2 can be joined on the central axis of the fixing disk 61. Each of the pull rods 12 extends from the inside of the fixator 6 to the outside of the fixator 6. The outer peripheral side of the shielding disk 63 is detachably connected to the outer peripheral side of the fixing disk 61, and each of the animal fixing devices is located between the shielding disk 63 and the fixing disk 61.

[0113] During implementation, the neutron beam can pass through the fixing disk 61 and irradiate the corresponding part of the experimental animal's body in the box body 2 through the gap on the animal fixing device. For other parts, due to the shielding plate 11, the radiation can be shielded, and the neutron beam will not irradiate other parts of the experimental animal. Since the shielding plate 11 can slide, the opening degree of the gap can be adjusted, and thus the irradiation dose can be adjusted. The specific increase or decrease amount of the adjusted radiation dose can be achieved through the pull rod 12 and the scale 121 thereon. After the animal fixing device is fixed to the fixator 6, the pull rod 12 extends outside the fixator 6. Then, during the radiation irradiation process, the opening degree of the gap can be adjusted in real time without disassembling the fixator 6 or the animal fixing device, realizing the on-line adjustment of the radiation dose.

[0114] Embodiment 9. As a preference, for the technical solution of Embodiment 8, each of the box bodies 2 has an inclined portion 21. One end of each of the box bodies 2 having the inclined portion 21 is also a tip. Each of the tips can be joined on the central axis of the fixing disk 61, and after each of the inclined portions 21 is joined, a multi-faceted hollow cone side surface is formed.

[0115] Embodiment 10. On the basis of Embodiment 8, this embodiment provides a method for real-time regulation of radiation dose, using the fixator 6 equipped with the animal experiment device as in Embodiment 8, including the following steps:

[0116] S1. Obtain the target radiation dose;

[0117] S2. According to the third mapping relationship, obtain the target scale value;

[0118] S3. Pull each of the pull rods 12 to make each of the pull rods 12 reach the target scale position;

[0119] S4. Complete the real-time adjustment of the radiation dose.

[0120] Specifically, in step S1, the obtained target radiation dose is determined according to specific experimental protocol parameters.

[0121] In specific implementation, the following steps are included: First, fix multiple experimental animals to the corresponding animal fixing devices respectively; then install each animal fixing device with an experimental animal fixed thereon on the fixing plate 61 respectively, and connect the fixing plate 61 with the shielding plate 63; then turn on the neutron source and irradiate the fixator 6 from one side of the fixing plate 61; when it is necessary to adjust the radiation dose, obtain the target scale value according to the third mapping relationship; pull each pull rod 12 to make each pull rod 12 reach the target scale position to complete the real-time adjustment of the radiation dose.

[0122] Specifically, for the third mapping relationship in step S2, formula (5) in Embodiment 2 is adopted, which will not be elaborated here.

[0123] In summary, adopting the animal fixing device, fixator and real-time radiation dose regulation method disclosed by the present invention has the following technical effects:

[0124] 1. The animal fixing device of the present invention has a shielding plate structure with adjustable position, and can perform real-time online position adjustment by pulling the pull rod, and further can adjust the opening degree of the gap, and further can adjust the irradiation dose. The specific increase or decrease amount of the adjusted radiation dose can be realized by the pull rod and the scale thereon. After the animal fixing device is fixed to the fixator, the pull rod extends outside the fixator. Then, during the radiation irradiation process, the opening degree of the gap can be adjusted in real time without disassembling the fixator or the animal fixing device, realizing the online adjustment of the radiation dose, providing an intuitive dose control means for experimental personnel, and thus improving the accuracy and reliability of the experiment.

[0125] 2. The present invention provides a third mapping relationship between the scale value of the scale and the radiation dose. By observing the scale value outside the fixator, the radiation dose at this time can be calculated according to the third mapping relationship, realizing the online and accurate adjustment of the radiation dose. At the same time, the control of the irradiation area is also realized, which helps to improve the accuracy and reliability of the experiment.

[0126] 3. The present invention uses a torsion type fixing belt to fix animals, adds a sliding head holder, and can closely fit according to the body size of the animals to ensure that the animals remain stable during blood collection and irradiation. Compared with the fixing methods in the prior art, the fixing effect of the present invention is more stable and reliable, avoiding errors in blood collection or irradiation caused by animal movement.

[0127] 4. The present invention not only improves the accuracy and reliability of experiments, but also enhances the experimental efficiency. Experimenters can complete experiments more quickly and reduce unnecessary repeated experiments. In addition, the cost of the present invention is relatively low, it is easy to operate and maintain, reducing the operation difficulty and time cost of experimenters.

[0128] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, or the conventional placement orientation or positional relationship when the inventive product is in use. The use of these terms is only for the convenience of describing the present invention and simplifying the description, and does not mean that the indicated device or element must have a specific orientation, be constructed and operated in a specific orientation, and should not be construed as a limitation to the present invention. In addition, terms such as "first", "second", "third", etc. are only used to distinguish different components or steps, and are not used to indicate or imply relative importance. Additionally, terms such as "horizontal" and "vertical" do not mean that the components must be absolutely horizontal or hanging vertically, but allow for a certain degree of inclination. For example, "horizontal" only means that its direction is closer to the horizontal state relative to "vertical", rather than requiring the structure to be completely horizontal. In the description of the present invention, it should also be noted that unless otherwise clearly specified and defined, terms such as "set", "installed", "connected", "coupled" should be understood in a broad sense. For example, the connection can be a fixed connection, a detachable connection or an integral connection; it can be a mechanical connection, an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and can also be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0129] It should also be noted that the present invention is illustrated by several embodiments. Those skilled in the art should understand that without departing from the core spirit and scope of the present invention, various modifications, adjustments or equivalent replacements can be made to the features in these embodiments. According to the guiding ideology of the present invention, technicians can make appropriate adjustments to the embodiments according to specific application scenarios and materials without exceeding the protection scope of the present invention. It should be pointed out that the embodiments described in the present invention are only a part of the numerous embodiments of the present invention, rather than all. Each component of the embodiments of the present invention shown in the drawings can be arranged and designed in different configurations according to actual needs. Therefore, the above detailed description of the embodiments shown in the drawings is not intended to limit the protection scope of the present invention, but only to elaborate on some embodiments of the present invention. The protection scope of the present invention should not be limited to the specific embodiments disclosed herein. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative labor shall fall within the protection scope of the present invention.

Claims

1. An animal fixing device, which is used to be fixed inside a fixator, and is characterized in that, It includes a box body and a radiation adjustment component. The box body is used to fix the body of the experimental animal, and the top of the box body has an opening; The radiation adjustment component includes a shielding plate that can shield radiation, and the shielding plate is slidably connected to the top of the box body; There is a gap between one end of the shielding plate and the top of the side wall of the box body; When the shielding plate slides on the top of the box body, the opening degree of the gap can increase or decrease; A pull rod is fixed at one end of the shielding plate away from the gap. A scale is provided on the pull rod. The pull rod is used to adjust the position of the shielding plate during radiation irradiation, and the scale is used to mark the position of the shielding plate; After the animal fixing device is fixed in the fixator, the pull rod extends from the inside of the fixator to the outside of the fixator.

2. The animal fixing device according to claim 1, wherein The third mapping relationship between the scale value of the scale and the radiation dose is used to adjust the radiation dose by adjusting the scale value: D B = (Ф0 - λA0 / (kL))tσ B N B κ B RBE; Among them, Ф0 is the thermal neutron flux density at the beam output, λ is a confidential constant, A0 is the initial area of the beam current at the beam output, k is the area coefficient, L is the calibration value, t is the irradiation time, σ B Neutron therapy capture cross-section, N B Boron concentration in the tumor, κ B Dose conversion coefficient, RBE relative biological effectiveness coefficient.

3. The animal fixing device according to claim 1, characterized in that, The box body includes a bottom plate. A fixing plate is slidably connected near the bottom plate. Straps are provided on the fixing plate. The two ends of the straps respectively pass through the fixing plate and extend to one side of the bottom plate. The two ends of the straps are respectively fixed to adjustment knobs, and the adjustment knobs can adjust the tightness of the straps.

4. The animal fixing device according to claim 3, characterized in that, At the position of the fixing plate corresponding to the gap, a head holder is provided for holding the head of the experimental animal.

5. The animal fixing device according to claim 3, characterized in that, One side of the bottom plate has an inclined portion extending outwardly. There is an angle between the plane of the inclined portion and the plane of the bottom plate, and the angle is an obtuse angle; A head holder is provided on the inclined portion for holding the head of the experimental animal.

6. The animal fixing device according to claim 4 or 5, characterized in that, The head holder includes a first clamping block and a second clamping block. The first clamping block and the second clamping block are respectively slidably connected to the fixing plate, and the head of the experimental animal is placed between the first clamping block and the second clamping block.

7. The animal fixing device according to claim 3, characterized in that, One side of the bottom plate extends upward to form a first side plate, and the other side of the bottom plate extends upward to form a second side plate; First upper sliding grooves and second upper sliding grooves are respectively provided at the tops of the first side plate and the second side plate; The two sides of the shielding plate are respectively slidably connected in the first upper sliding groove and the second upper sliding groove; First lower sliding grooves and second lower sliding grooves are respectively provided at positions of the first side plate and the second side plate close to the bottom plate; The two sides of the fixing plate are respectively slidably connected in the first lower sliding groove and the second lower sliding groove.

8. A fixator, characterized in that, It includes a fixed disk and an occlusion disk. A plurality of animal fixing devices as described in claim 1 are fixed on the fixed disk; Each of the animal fixing devices is radially and evenly distributed along the circumference with the center of the fixed disk as the center; One end of the box body of each animal fixing device away from the pull rod is a tip, and one end of the corresponding bottom plate has an acute-angled triangular end; After each animal fixing device is fixed on the fixed disk, the tips of each box body can be joined on the central axis of the fixed disk; Each pull rod extends from the inside of the fixator to the outside of the fixator; The outer peripheral side of the occlusion disk is detachably connected to the outer peripheral side of the fixed disk, and each animal fixing device is located between the occlusion disk and the fixed disk.

9. A real-time radiation dose regulation method, which uses the fixture installed with the animal experiment device as described in claim 8, and includes the following steps: S1. Obtain the target radiation dose; S2. Obtain the target scale value according to the third mapping relationship; S3. Pull each pull rod so that each pull rod reaches the target scale position; S4. Complete the real-time adjustment of the radiation dose.

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