Vaccination cold compress patch and application thereof

Abstract

The invention relates to a vaccination cold compress patch and application thereof, and belongs to the technical field of biology. The cold compress patch sequentially comprises a back lining layer, a medicine layer and a gel layer from top to bottom, wherein the medicine layer is prepared from the following raw materials in parts by weight: 8 to 12 parts of honeysuckle flower, 8 to 12 parts of folium isatidis, 2 to 4 parts of herba menthae and 4 to 6 parts of fructus crataegi. The medicine layer is arranged on the upper layer of the gel layer, so that the medicine layer is not in direct contact with the skin, the medicine effect is relieved, the inhibiting effect on local adverse reactions after vaccination is better, the local adverse reactions after vaccination can be rapidly and effectively reduced under the interaction of all the medicines, such as fever, redness and swelling, pain and allergy, and the curative effect is good. The tolerance of the skin after the vaccination is improved.

Description

Technical Field

[0001] The present invention belongs to the field of biotechnology, and particularly relates to a cold compress patch for vaccination and its application. Background Art

[0002] The general reactions after vaccination include local reactions and systemic reactions. The local reaction is the local tissue reaction caused by the stimulation of the vaccine, which mostly occurs within 24 hours after vaccination. Redness, swelling and pain may occur at the injection site, and lymph node swelling and pain are occasionally seen. Generally, it gradually subsides after 24 - 48 hours. Usually, when the diameter of redness and induration is less than 15mm, no treatment is required, but the subsidence time is relatively long, about 24h or longer. For local reactions with a redness diameter and induration of 15 - 30mm, cold compress is applied within the first 24 hours and hot compress is applied in the later 24 hours, several times a day, 10 - 15 minutes each time. When the redness is obvious, it is wet-compressed with fresh potato slices several times a day. The treatment frequency is high and the subsidence time is long. Therefore, the local reaction after vaccination leads to poor tolerance of vaccination, especially for people with easy allergies. Therefore, there is an urgent need for a method that can quickly and effectively reduce the local adverse reactions after vaccination.

[0003] The cold compress patch is a plaster improved from traditional cold compress methods (such as cold water, ice water, alcohol, etc.). Currently, it is mostly used for physical cooling of high fever, local sedation and recovery after surgery, or adjuvant treatment of rheumatic bone diseases, etc. Among them, the cold compress patch for rheumatic bone diseases mostly adopts a medicated cold compress patch. In order to obtain better drug efficacy, the drug layer is directly in contact with the skin to enable the drug to quickly penetrate the skin and achieve the purpose of quickly reducing inflammation and relieving pain for bone joints. Currently, there is no report on using a cold compress patch to reduce local adverse reactions after vaccination. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to provide a cold compress patch for vaccination and its application. After using the cold compress patch for vaccination, it can quickly and effectively reduce the adverse reactions after vaccination, and reduce local redness, fever, pain and allergic reactions.

[0005] The present invention provides a cold compress patch for vaccination, which successively includes a backing layer, a drug layer and a gel layer from top to bottom; the drug layer includes the following drugs in parts by weight: 8 - 12 parts of honeysuckle, 8 - 12 parts of folium isatidis, 2 - 4 parts of mint and 4 - 6 parts of hawthorn.

[0006] Preferably, the drug layer further includes a hydrogel, and the hydrogel includes xanthan gum and glycerol, and the mass ratio of xanthan gum to glycerol is (0.8 - 1.2)∶(5 - 10).

[0007] Preferably, the mass ratio of the drug in the drug layer to the hydrogel is (3 - 7)∶100.

[0008] Preferably, the gel layer comprises xanthan gum and glycerol, and the mass ratio of xanthan gum to glycerol is (0.8 - 1.2)∶(5 - 10).

[0009] Preferably, the backing layer comprises non-woven fabric.

[0010] The present invention also provides a preparation method of the cold compress patch, comprising the following steps:

[0011] Flos Lonicerae, Folium Isatidis, Herba Menthae and Fructus Crataegi are mixed and pulverized into medicinal powder;

[0012] Xanthan gum is added to glycerol, then mixed with water, heated to 75°C - 85°C, and stirred to obtain hydrogel;

[0013] Take a part of the hydrogel and mix it with the medicinal powder, cool it to 30°C - 35°C, coat it on the backing layer, and let it stand to form a drug layer;

[0014] The remaining hydrogel is cooled to 30°C - 35°C and coated on the drug layer, and let it stand to form a gel layer.

[0015] Preferably, the particle size of the medicinal powder is < 10 μm.

[0016] Preferably, the coating thickness is 0.8 - 1.1 mm.

[0017] The present invention also provides an application of the cold compress patch for vaccination or the preparation method in the preparation of a product for reducing local adverse reactions after vaccination.

[0018] The present invention also provides an application of the cold compress patch for vaccination or the preparation method in the preparation of a product for treating skin allergy.

[0019] Beneficial effects:

[0020] The present invention provides a cold compress patch for vaccination, which sequentially comprises a backing layer, a drug layer and a gel layer from top to bottom. By arranging the drug layer on the upper layer of the gel layer, the drug layer does not directly contact the skin, not only the drug effect is slow-releasing, but also the inhibitory effect on local adverse reactions after vaccination is better. Under the combined action of various drugs and the synergistic effect of the hydrogel, it can quickly and effectively reduce local adverse reactions after vaccination, reduce phenomena such as fever, swelling, pain and allergy, and improve the skin tolerance after vaccination. At the same time, the cold compress patch for vaccination of the present invention can also effectively reduce the area of erythema and edema caused by skin allergy, achieving the effect of treating skin allergy. Specific embodiments

[0021] The present invention provides a cold compress patch for vaccination. The cold compress patch sequentially includes a backing layer, a drug layer, and a gel layer from top to bottom. The drug layer includes the following drugs in parts by weight: 8-12 parts of honeysuckle, 8-12 parts of folium isatidis, 2-4 parts of mint, and 4-6 parts of hawthorn. Preferably, it includes the following drugs in parts by weight: 9-11 parts of honeysuckle, 9-11 parts of folium isatidis, 2.5-3.5 parts of mint, and 4.5-5.5 parts of hawthorn. More preferably, it includes the following drugs in parts by weight: 10 parts of honeysuckle, 10 parts of folium isatidis, 3 parts of mint, and 5 parts of hawthorn. The present invention has no special limitation on the sources of the honeysuckle, folium isatidis, mint, and hawthorn, and conventional commercially available products in the art can be used.

[0022] The drug compatibility in the drug layer of the present invention is reasonable, and the combined action can achieve the effects of detumescence, pain relief, and anti-allergy. Although mint and hawthorn in the present invention cannot fully exert the effects of detumescence, pain relief, and anti-allergy when used alone, their addition can significantly improve the drug efficacy and achieve a synergistic effect.

[0023] In the present invention, the drug layer preferably further includes a hydrogel. The hydrogel preferably includes xanthan gum and glycerol. The mass ratio of xanthan gum to glycerol is preferably (0.8-1.2):(5-10), more preferably (0.9-1.1):(6-9), and further preferably 1:8. The hydrogel is preferably prepared from xanthan gum, glycerol, and water. The mass ratio of the drug in the drug layer to the hydrogel is preferably (3-7):100, more preferably (4-6):100, and further preferably 5:100. The drug layer is preferably obtained by coating the mixture of the drug and the hydrogel on the backing layer.

[0024] Preferably, the gel layer preferably includes xanthan gum and glycerol. The mass ratio of xanthan gum to glycerol is preferably (0.8-1.2):(5-10), more preferably (0.9-1.1):(6-9), and further preferably 1:8. The gel layer is preferably obtained by coating the hydrogel on the drug layer. The hydrogel is preferably prepared from xanthan gum, glycerol, and water.

[0025] The drug layer of the present invention is located on the upper layer of the gel layer, avoiding direct contact between the drug layer and the skin, which can make the drug action more soothing and improve the effect of the drug in reducing local adverse reactions after vaccination.

[0026] The backing layer preferably includes non-woven fabric.

[0027] The present invention does not particularly limit the sources of glycerol, xanthan gum and non-woven fabric, and conventional commercially available products in the art can be used. In the present invention, there are no particular limitations on the shape, size and relative positions of the vaccination cold compress patch. In one embodiment: the cold compress patch can be circular or square, the drug layer and the gel layer can be located at the central position of the backing layer, the size of the backing layer can be larger than that of the drug layer and the gel layer, and the drug layer and the gel layer can be a square of 1.5 cm × 1.5 cm or a circle with a diameter of 1.5 cm. The vaccination cold compress patch is preferably used for children or adults. When used for children, a pattern can preferably be provided on the side of the backing layer away from the drug layer.

[0028] The present invention also provides a method for preparing the cold compress patch, comprising the following steps:

[0029] Flos Lonicerae, Folium Isatidis, Herba Menthae and Fructus Crataegi are mixed and pulverized into a medicinal powder; the particle size of the medicinal powder is preferably <10 μm. Pulverizing to the above particle size can not only make the drug disperse better in the gel, but also facilitate the penetration of the medicinal efficacy components and improve the medicinal efficacy; the present invention does not particularly limit the pulverizing method, and conventional pulverizing methods in the art can be used. In one embodiment, an ultrafine pulverizing method can be selected.

[0030] Xanthan gum is added to glycerol, and then mixed with water and heated to 75 °C to 85 °C, and stirred to obtain a hydrogel; adding xanthan gum to glycerol and then mixing with water can make xanthan gum disperse and dissolve better. Further heating and stirring can promote gelation to form a hydrogel. The heating temperature can be 75 °C, 78 °C, 80 °C, 82 °C or 85 °C.

[0031] Take a part of the hydrogel and mix it with the medicinal powder. The present invention does not particularly limit the specific amount of the hydrogel taken, and the conventional dosage for preparing the drug gel layer in the art can be used. The mixing is preferably carried out while it is hot to improve the uniformity of drug distribution; after mixing, it is cooled to 30 °C to 35 °C, more preferably cooled to 30 °C, 31 °C, 32 °C, 33 °C, 34 °C or 35 °C, and then coated on the backing layer; cooling to this temperature can increase the viscosity of the hydrogel and medicinal powder mixture and reduce its fluidity, so as to be coated on the backing layer more evenly; the thickness of the coating is preferably 0.8 to 1.1 mm, more preferably 0.8 mm, 0.9 mm, 1 mm or 1.1 mm. After coating, it is left standing until the hydrogel containing the medicinal powder solidifies and forms a drug layer;

[0032] The remaining hydrogel is cooled to 30°C to 35°C, more preferably cooled to 30°C, 31°C, 32°C, 33°C, 34°C or 35°C, to reduce the fluidity of the hydrogel, and then coated on the drug layer; the coating thickness is preferably 0.8 to 1.1 mm, more preferably 0.8 mm, 0.9 mm, 1 mm or 1.1 mm; in the present invention, the coating thickness of the drug layer and the gel layer may be the same or different; after coating, it is left standing until the hydrogel solidifies and forms a gel layer.

[0033] In the present invention, the vaccination cold compress patch is preferably wrapped with a protective layer to achieve the effects of anti-sticking and preventing contamination, thereby avoiding contaminating the wound when using the cold compress patch. The present invention has no special limitation on the material of the protective layer, and the materials commonly used in the art for the protective layer of cold compress patches can be used. In one embodiment, a polyethylene film can be selected as the protective layer.

[0034] The present invention also provides the use of the vaccination cold compress patch or the preparation method thereof in the preparation of products for reducing local adverse reactions after vaccination. The vaccination cold compress patch provided by the present invention can reduce local adverse reactions after vaccination, such as redness, fever, pain and allergic reactions, through the combined action of the drugs in the drug layer and then in synergistic action with the gel layer.

[0035] The present invention also provides the use of the vaccination cold compress patch or the preparation method thereof in the preparation of products for treating skin allergies. The vaccination cold compress patch provided by the present invention can also treat skin allergic reactions and reduce the area of erythema and edema of allergic skin.

[0036] The technical solutions provided by the present invention will be described in detail below in conjunction with embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0037] In the following embodiments, unless otherwise specified, all are conventional methods.

[0038] In the following embodiments, the materials, reagents, etc. used, unless otherwise specified, can be obtained from commercial channels.

[0039] Example 1

[0040] A vaccination cold compress patch

[0041] It is composed of a backing layer, a drug layer, and a gel layer from top to bottom. The drugs contained in the drug layer are: honeysuckle, folium isatidis, mint, and hawthorn.

[0042] Preparation method of the vaccination cold compress patch:

[0043] (1) 10 g of honeysuckle, 10 g of folium isatidis, 3 g of mint, and 5 g of hawthorn are mixed and ultrafinely pulverized to a particle size of <10 μm to obtain a medicinal powder.

[0044] (2) Add 1 g of xanthan gum into 8 g of glycerol, disperse evenly, then add water, heat to 80 °C, and stir evenly to obtain 100 g of hydrogel;

[0045] (3) Take 1 / 2 of the hydrogel from step (2), while it is still hot, add 5% (add 5 g of medicinal powder per 100 g of hydrogel) of medicinal powder, stir evenly to make the medicinal powder evenly distributed in the hydrogel. When the temperature drops to 32 °C, evenly coat it on the non-woven fabric with a coating thickness of 1 mm, and let it stand and form on the non-woven fabric to form a drug layer;

[0046] (4) Take the remaining 1 / 2 of the hydrogel from step (2). When the temperature drops to 32 °C, evenly coat it on the drug layer with a coating thickness of 1 mm, and let it stand and form to form a gel layer; obtain a cold compress patch for vaccination. Then wrap the cold compress patch for vaccination with a polyethylene film (protective layer) and store it for standby.

[0047] Example 2

[0048] A cold compress patch for vaccination

[0049] It consists of a backing layer, a drug layer, and a gel layer from top to bottom in sequence. The drugs contained in the drug layer are: honeysuckle, folium isatidis, mint, and hawthorn.

[0050] Preparation method of the cold compress patch for vaccination:

[0051] (1) Mix 12 g of honeysuckle, 8 g of folium isatidis, 4 g of mint, and 4 g of hawthorn, and then ultrafinely pulverize them to a particle size of <10 μm to obtain medicinal powder.

[0052] (2) Add 0.8 g of xanthan gum into 5 g of glycerol, disperse evenly, then add water, heat to 85 °C, and stir evenly to obtain 100 g of hydrogel;

[0053] (3) Take 1 / 2 of the hydrogel from step (2), while it is still hot, add 7% of the medicinal powder, stir evenly to make the medicinal powder evenly distributed on the hydrogel. When the temperature drops to 30 °C, evenly coat it on the non-woven fabric with a coating thickness of 0.8 mm, and let it stand and form on the non-woven fabric to form a drug layer;

[0054] (4) Take the remaining hydrogel from step (2). When the temperature drops to 30 °C, evenly coat it on the drug layer with a coating thickness of 0.8 mm, and let it stand and form to form a gel layer; obtain a cold compress patch for vaccination. Then wrap the cold compress patch for vaccination with a polyethylene film (protective layer) and store it for standby.

[0055] Example 3

[0056] A cold compress patch for vaccination

[0057] It consists of a backing layer, a drug layer, and a gel layer from top to bottom. The drugs contained in the drug layer are: honeysuckle, folium isatidis, mint, and hawthorn.

[0058] Preparation method of cold compress patch for vaccination:

[0059] (1) Mix 8 g of honeysuckle, 12 g of folium isatidis, 2 g of mint, and 6 g of hawthorn, and then ultrafinely pulverize them to a particle size of < 10 μm to obtain a drug powder.

[0060] (2) Add 1.2 g of xanthan gum to 10 g of glycerol, disperse evenly, then add water, heat to 75 °C, and stir evenly to obtain 100 g of hydrogel;

[0061] (3) Take 1 / 2 of the hydrogel from step (2), while it is still hot, add 3% of the drug powder, stir evenly to make the drug powder evenly distributed on the hydrogel. When the temperature drops to 35 °C, evenly coat it on the non-woven fabric with a coating thickness of 1.1 mm, and let it stand and form on the non-woven fabric to form a drug layer;

[0062] (4) Take the remaining hydrogel from step (2), when the temperature drops to 35 °C, evenly coat it on the drug layer with a coating thickness of 1.1 mm, let it stand and form to form a gel layer; obtain the cold compress patch for vaccination. Then wrap the cold compress patch for vaccination with a polyethylene film (protective layer) and store it for later use.

[0063] Comparative Example 1

[0064] The difference from Example 1 is only that the drug layer does not contain hawthorn, and the rest are the same as in Example 1.

[0065] Comparative Example 2

[0066] The difference from Example 1 is only that the drug layer does not contain mint, and the rest are the same as in Example 1.

[0067] Comparative Example 3

[0068] The difference from Example 1 is only that the mass of mint in step (1) is 8 g, and the rest are the same as in Example 1.

[0069] Comparative Example 4

[0070] The difference from Example 1 is only that the mass of hawthorn in step (1) is 10 g, and the rest are the same as in Example 1.

[0071] Comparative Example 5

[0072] The difference from Example 1 is only that:

[0073] Step (3) is: take 1 / 2 of the hydrogel from step (2), when the temperature drops to 32 °C, evenly coat it on the non-woven fabric with a coating thickness of 1 mm, and let it stand and form to form a gel layer;

[0074] Step (4) is as follows: Take the remaining hydrogel from step (2), add 5% medicinal powder to the hydrogel while it is still hot, stir evenly to make the medicinal powder evenly distributed on the hydrogel. When the temperature drops to 32°C, coat it evenly on the gel layer with a coating thickness of 1 mm, and let it stand and form on the gel layer to form a drug layer; thus obtaining a cold compress patch for vaccination. Then wrap the cold compress patch for vaccination with a polyethylene film (protective layer) and store it for later use.

[0075] The rest are the same as in Example 1.

[0076] Test Example 1

[0077] Effect of the cold compress patch for vaccination on local reactions after vaccination

[0078] After vaccination, the skin is prone to local reactions such as redness, fever, pain, and inflammation. These reactions are mainly caused by local tissue damage and drug allergy due to acupuncture. Therefore, the effect of the cold compress patch for vaccination on guinea pig skin allergy and after intramuscular injection in guinea pigs was studied to investigate the effect of the cold compress patch for vaccination on local reactions after vaccination.

[0079] 1. Effect of the cold compress patch for vaccination on local skin allergy in guinea pigs

[0080] Sensitizing contact: Take 90 healthy guinea pigs, with an equal number of males and females, and randomly divide them into 9 groups, namely Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, Comparative Example 4 group, Comparative Example 5 group, and blank group.

[0081] 24 h before administering the sensitizer, depilate 3 cm × 3 cm symmetrically on both sides of the backs of 90 guinea pigs and keep the skin intact. Apply 0.2 mL of 1% 2,4-dinitrochlorobenzene as the sensitizer to the depilated area on the left side of the animal. After 6 h, remove the sensitizer, and repeat it once each on the 7th day and the 14th day (a total of 3 times of administering the sensitizer, with the same dose). 14 days after the last administration of the sensitizer for sensitization, administer 0.1% 2,4-dinitrochlorobenzene again. After 6 h, remove the test drug, and immediately observe the area of skin erythema and edema in each group. The results show that more than 80% of the area of erythema and edema occurred in the depilated area on the left side of all animals, and there was no erythema or edema in the depilated area on the right side. The number of animals with more than 80% of the area of erythema and edema in the depilated area on the left side was recorded as the number of animals in stage 1.

[0082] After the observation, except for the blank group, the left depilated areas of the guinea pigs in each group were applied with the prophylactic vaccination cold compress patches prepared in the above Examples 1-3 and Comparative Examples 1-5 (the cold compress patches prepared in Examples 1-3 were used for the groups of Examples 1-3 in sequence, and the cold compress patches prepared in Comparative Examples 1-5 were used for the groups of Comparative Examples 1-5 in sequence), and the blank group was not treated with application. The number of animals with more than half reduction in the skin erythema and edema area and disappearance of the skin erythema and edema area in the left depilated area of the guinea pigs was counted 2 h and 6 h after the application respectively. The number of animals with more than half reduction in the skin erythema and edema area 2 h after the application was recorded as the number of animals in stage 2-1, and the number of animals with disappearance of the skin erythema and edema area 2 h after the application was recorded as the number of animals in stage 2-2; the number of animals with more than half reduction in the skin erythema and edema area 6 h after the application was recorded as the number of animals in stage 3-1, and the number of animals with disappearance of the skin erythema and edema area 6 h after the application was recorded as the number of animals in stage 3-2. The statistical results of the number of animals in each stage are shown in Table 1 below.

[0083] Table 1 Number of animals in different stages of skin erythema and edema in each group of guinea pigs

[0084]

[0085]

[0086] As can be seen from Table 1, the cold compress patches of Examples 1-3 and Comparative Examples 1-5 were significantly superior to the control group in terms of the effects on erythema and edema caused by skin allergy. Among them, the groups of Examples 1-3 were the best, and the effective rates of reducing the skin erythema and edema area reached 100% both 2 h and 6 h after the application, which were significantly superior to 60% and 80% of Comparative Example 1, 50% and 70% of Comparative Example 2, 70% and 90% of Comparative Example 3, 70% and 90% of Comparative Example 4, and 80% and 90% of Comparative Example 5. At the same time, the effective rate of complete disappearance of the erythema and edema area and complete cure reached 80%-90% 6 h after the application of the cold compress patches of Examples 1-3, while the highest of Comparative Examples 1-5 was only 20%. Although in the first 2 h, the erythema and edema area of 80% of the guinea pigs in the group of Comparative Example 5 was reduced by more than half, there were no guinea pigs with complete disappearance of the erythema and edema area 6 h after the application. It shows that whether it is the change of the formula and dosage or the different setting order of each layer of the cold compress patch, it will lead to a significant decrease in the application effect.

[0087] 2. Influence of prophylactic vaccination cold compress patch on the intramuscular skin of guinea pigs

[0088] Sensitizing contact: 90 healthy guinea pigs, half male and half female, were randomly divided into 7 groups, namely Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, Comparative Example 4 group, Comparative Example 5 group and blank group.

[0089] Twenty-four hours before acupuncture stimulation, the outer thigh muscles on both hind limbs of 90 guinea pigs were symmetrically depilated in an area of 2 cm × 2 cm, and the skin was kept intact. The center point of the depilated area on the left side of the guinea pig was selected, and 0.2 mL of normal saline was injected into the muscle at the center point on the left side of the guinea pig using a syringe. After acupuncture, except for the blank group, the remaining groups were immediately applied with the prophylactic cold compresses prepared in Examples 1-3 and Comparative Examples 1-5 above (the groups of Examples 1-3 were sequentially applied with the cold compresses prepared in Examples 1-3, and the groups of Comparative Examples 1-5 were sequentially applied with the cold compresses prepared in Comparative Examples 1-5), while the blank group was not treated with application.

[0090] After application, the time when the guinea pigs actively tried to lick the injection site was observed (the time from the end of injection and application to the last attempt to lick the injection site). The results showed that the time when the guinea pigs in the blank group actively tried to lick the injection site was 8-10 minutes, while after applying the cold compresses of Examples 1-3 and Comparative Examples 1-5, the time when the guinea pigs actively tried to lick the injection site was significantly shortened, up to 3 minutes. Among them, the time when the guinea pigs actively tried to lick the injection site after applying the cold compresses of Examples 1-3 was only 1 minute at most, which was significantly better than the cold compress effects of other groups. The guinea pigs actively tried to lick the injection site mainly due to the pain after acupuncture, indicating that the cold compress of the present invention can play a pain-relieving and soothing effect after vaccination.

[0091] Then, the number of animals with skin flushing, swelling, induration or local fever on the left side of the guinea pigs was counted at 0.5 h, 1 h and 12 h after application respectively. The statistical results of the number of animals in each stage are shown in Table 1 below.

[0092] Table 2 Number of animals with skin swelling, induration or local fever in each group of guinea pigs

[0093]

[0094] As can be seen from Table 2, the cold compresses of Examples 1-3 and Comparative Examples 1-5 were significantly better than the control group in terms of the effects on local reactions such as skin flushing, swelling, induration or local fever after intramuscular injection. Among them, the groups of Examples 1-3 were the best, and all local swelling and fever reactions caused by intramuscular injection in all guinea pigs could be relieved in 0.5 h. Although the cold compresses of Comparative Examples 1-5 could also significantly relieve the corresponding symptoms, the effective rate was lower than that of Examples 1-3, and the onset was slow.

[0095] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A cold compress patch for vaccination, characterized in that, The cold compress patch sequentially includes a backing layer, a drug layer, and a gel layer from top to bottom; the drug layer includes the following drugs in parts by weight: 8-12 parts of honeysuckle, 8-12 parts of folium isatidis, 2-4 parts of mint, and 4-6 parts of hawthorn.

2. The cold compress patch according to claim 1, wherein The drug layer further includes a hydrogel, and the hydrogel includes xanthan gum and glycerol, and the mass ratio of xanthan gum to glycerol is (0.8-1.2):(5-10).

3. The cold compress patch according to claim 2, wherein The mass ratio of the drug in the drug layer to the hydrogel is (3-7):

100.

4. The cold compress patch according to claim 1, wherein The gel layer includes xanthan gum and glycerol, and the mass ratio of xanthan gum to glycerol is (0.8-1.2):(5-10).

5. The cold compress patch according to claim 1, characterized in that, The backing layer includes non-woven fabric.

6. The preparation method of the cold compress patch according to any one of claims 1 to 5, characterized in that, It includes the following steps: Honeysuckle, folium isatidis, mint, and hawthorn are mixed and pulverized into medicinal powder. Xanthan gum is added to glycerol, then mixed with water, heated to 75°C - 85°C, and stirred to obtain a hydrogel. Take a part of the hydrogel and mix it with the medicinal powder, cool it to 30°C - 35°C, coat it on the backing layer, and let it stand to form a drug layer. The remaining hydrogel is cooled to 30°C - 35°C, coated on the drug layer, and let it stand to form a gel layer.

7. The method according to claim 6, wherein The particle size of the medicinal powder < 10 μm.

8. The method according to claim 6, wherein The coating thickness is 0.8 - 1.1 mm.

9. Use of the cold compress patch for vaccination according to any one of claims 1 - 5 or the preparation method according to any one of claims 6 - 8 in the preparation of a product for reducing local adverse reactions after vaccination.

10. Use of the cold compress patch for vaccination according to any one of claims 1 - 5 or the preparation method according to any one of claims 6 - 8 in the preparation of a product for treating skin allergies.

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