Analgesic ointment and preparation method thereof

Abstract

The present invention belongs to the technical field of compositions and discloses an analgesic ointment and its preparation method. The analgesic ointment comprises: Component A: a thickener, methylparaben, and water; Component B: an emulsifier, menthyl lactate, and menthol; Component C: a neutralizer, panthenol, white willow bark extract, and water; and Component D: phenoxyethanol, menthone glycerol ketal, CTR50, and water. The preparation method comprises: preparing CTR50; adding the thickener and methylparaben to water and mixing to obtain Component A; adding the materials in Component B to Component A to obtain a mixed material; sequentially adding the white willow bark extract, the neutralizer, and panthenol dissolved in water by heating to the mixed material; and finally adding the materials in Component D and mixing to obtain the ointment. The present invention incorporates Corydalis root extract into the analgesic ointment in the form of CTR50, compounding it with the other components. This provides the ointment with the ability to relieve labor pains while maintaining its stability, and can alleviate symptoms such as various strains, sprains, and lumbar muscle strain.

Description

Technical Field

[0001] The invention belongs to the technical field of compositions, and particularly relates to an analgesic ointment and a preparation method thereof. Background Art

[0002] With changes in modern working environments and lifestyles, inflammation, strains and sprains, lower back and knee pain, shoulder and neck discomfort, and other symptoms caused by various factors are increasingly impacting people's health and daily lives. Conventional Western medicine treatments typically involve simple trauma management and symptomatic treatment, which can relieve inflammation and pain in a short period of time but often cause local skin irritation and side effects. While effective quickly, these treatments only address the symptoms and not the root cause. Furthermore, soft tissue injuries rely solely on the body's natural repair, and complete recovery still requires a long time. Botanicals, on the other hand, are natural medicines with minimal toxicity, high safety, and cost-effectiveness, and have gradually become the preferred choice for cosmetics and pharmaceuticals.

[0003] Corydalis yanhusuo (W.T. Wang), also known as Yanhusuo, Xuanhusuo, Yuanhusuo, and Yuanhusuo, is a perennial herbaceous plant in the Papaveraceae family and the genus Corydalis. Its rhizome is a well-known and commonly used traditional Chinese medicine, containing over 20 alkaloids. It is used to promote qi circulation, relieve pain, promote blood circulation, and treat traumatic injuries. Corydalis yanhusuo is primarily produced in Northeast China and northern Hebei Province, growing under sparse forests, in thickets at the edge of forests, and on moist hillsides. It is listed in the Chinese Pharmacopoeia as a traditional Chinese medicine.

[0004] Therefore, the present invention provides a plant extract analgesic ointment with soothing and analgesic effects, which has important clinical significance. Summary of the Invention

[0005] The present invention aims to solve at least one of the technical problems existing in the above-mentioned prior art. To this end, the present invention provides an analgesic ointment, which is prepared by compounding a Corydalis extract and other components, and has a soothing and analgesic effect, and can effectively relieve pain caused by joint strains and sprains, shoulder and neck discomfort, and lumbar muscle strain.

[0006] The invention also provides a preparation method of the analgesic ointment.

[0007] According to one aspect of the present invention, an analgesic ointment is provided, which comprises, calculated by the percentage of each component to the total weight of the analgesic ointment:

[0008] Component A: thickener 0.47-0.80%, methylparaben 0.13-0.18%, water 65.00-75.00%;

[0009] Component B: emulsifier 3.40-4.80%, menthyl lactate 0.18-0.23%, menthol 1.00-1.20%;

[0010] Component C: neutralizer 0.30-1.20%, panthenol 0.70-1.10%, white willow bark extract 0.50-1.30%, water 8.00-14.00%;

[0011] Component D: phenoxyethanol 0.20-0.80%, menthone glyceryl ketal 0.50-0.80%, CTR50 5.00-13.00%, water 1.80-2.50%.

[0012] In some embodiments of the present invention, based on the percentage of each component in the total weight of the analgesic ointment, the thickener includes: 0.17-0.25% carbomer and 0.30-0.55% sodium polyacrylate grafted starch.

[0013] In some embodiments of the present invention, the emulsifier includes, based on the percentage of each component in the total weight of the analgesic ointment, 2.80-3.80% of cetearyl alcohol and 0.60-1.00% of sodium polyacrylate / ethylhexyl stearate / tridecyl alcohol polyether-6.

[0014] In some embodiments of the present invention, the neutralizing agent is triethanolamine.

[0015] In some embodiments of the present invention, the CTR50 comprises, by mass percentage, 2.00-10.00% of Corydalis yanhusuo root extract, 70.00-85.00% of butylene glycol, 0.50-4.00% of citric acid, and 5.00-25.00% of dimethyl isosorbide.

[0016] In some embodiments of the present invention, the water is selected from deionized water.

[0017] According to another aspect of the present invention, a method for preparing the analgesic ointment is provided, comprising the following steps:

[0018] S1: Preparation of CTR50;

[0019] S2: adding a thickener and methylparaben to water and mixing to prepare component A;

[0020] S3: adding the emulsifier, menthyl lactate and menthol in component B to component A and mixing to obtain a mixed material;

[0021] S4: Add the willow bark extract dissolved in advance by heating with water to the mixture, then add the neutralizer and panthenol in component C, and finally add the phenoxyethanol, menthone glycerol ketal, CTR50 and water in component D, and mix to obtain the analgesic ointment.

[0022] In some embodiments of the present invention, the specific steps of preparing CTR50 in step S1 include:

[0023] A1: Mix butanediol and citric acid in a mass ratio of (2-3):1 and dissolve to obtain Solution A;

[0024] A2: Weigh the remaining butylene glycol in proportion, mix with the Corydalis yanhusuo root extract, and dissolve to obtain Solution B;

[0025] A3: Add the liquid A to the liquid B and mix to obtain liquid C; add isosorbide dimethyl ether to the liquid C in proportion, mix, and then process using a high-pressure microfluidizer to obtain the CTR50.

[0026] In some embodiments of the present invention, before step A1, the process further includes: weighing the Corydalis yanhusuo root extract and citric acid respectively according to proportions.

[0027] In some embodiments of the present invention, in step A1, the butanediol and the citric acid are mixed, and then heated in a water bath at 50-60° C. to dissolve the mixture to obtain the solution A.

[0028] In some embodiments of the present invention, in step A2, the butanediol and the Corydalis yanhusuo root extract are mixed, heated to 110-120° C., and stirred to dissolve to obtain the solution B.

[0029] In some embodiments of the present invention, in step A3, when the temperature of the solution B drops to 90-95° C., the solution A is added to the solution B and mixed to obtain the solution C.

[0030] In some embodiments of the present invention, step A3 uses the high-pressure microfluidizer for treatment 2 to 3 times to obtain the CTR50.

[0031] In some embodiments of the present invention, in step S2, the thickener is first added to the water for soaking and dispersion, and then the methylparaben is added, heated to 80-90° C., homogenized at 2500-3000 r / min for 3-5 minutes, stirred and cooled to obtain the component A.

[0032] In some embodiments of the present invention, in step S3, when the temperature of component A drops to 60-70° C., the stirring speed is reduced, and the emulsifier, menthyl lactate, and menthol in component B are added and mixed to obtain the mixed material.

[0033] In some embodiments of the present invention, in step S4, after the temperature of the mixed material drops to 50-60° C., the willow bark extract pre-dissolved by heating with water is added, and then the neutralizer and panthenol in component C are added.

[0034] In some embodiments of the present invention, in step S4, after the temperature drops below 45° C., phenoxyethanol, menthone glycerol ketal, CTR50 and water in component D are added, mixed, and the analgesic ointment is obtained.

[0035] According to a preferred embodiment of the present invention, there are at least the following beneficial effects:

[0036] The present invention incorporates the Corydalis root extract into an analgesic ointment in the form of CTR50, a dispersion system with buffering, solubilizing, and permeation-enhancing functions. The Corydalis root extract can be stably present in this system and has good solubility. Furthermore, this system can maintain the stability of the analgesic ointment. Adding CTR50 to the analgesic ointment appropriately increases the content of the Corydalis root extract, ensuring stable efficacy.

[0037] The present invention adds the Corydalis root extract to the analgesic ointment and compounds it with various components, so as to give the analgesic ointment the effect of soothing and relieving pain, and can relieve pain symptoms such as various strains, sprains, lumbar muscle strain and the like. DETAILED DESCRIPTION

[0038] The following will clearly and completely describe the concept of the present invention and the technical effects produced in conjunction with the embodiments, so as to fully understand the purpose, characteristics and effects of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention. The test methods used in the embodiments are all conventional methods unless otherwise specified; the materials, reagents, etc. used, unless otherwise specified, can all be reagents and materials obtained from commercial channels.

[0039] Example 1

[0040] In this embodiment, an analgesic ointment 1 is prepared, which comprises, by percentage of each component to the total weight of the analgesic ointment:

[0041] Component A: Carbomer 0.20%, sodium polyacrylate grafted starch 0.40%, methylparaben 0.15%, deionized water 74.25%;

[0042] Component B: Cetearyl Alcohol 3.20%, Sodium Polyacrylate / Ethylhexyl Stearate / Trideceth-60.80%, Menthyl Lactate 0.20%, Menthol 1.20%;

[0043] Component C: triethanolamine 0.30%, panthenol 0.80%, white willow bark extract 0.50%, deionized water 10%;

[0044] Component D: phenoxyethanol 0.40%, menthone glyceryl ketal 0.60%, CTR50 5.00%, deionized water 2.00%.

[0045] Among them, CTR50 includes: 5.00% of Corydalis yanhusuo root extract, 72.00% of butylene glycol, 3.00% of citric acid, and 20.00% of isosorbide dimethyl ether.

[0046] The specific preparation process is:

[0047] (1) Preparation of CTR50: 5.00% of Corydalis yanhusuo root extract and 3.00% of citric acid were weighed separately;

[0048] According to the mass ratio of butanediol to citric acid of 2:1, weigh butanediol, add citric acid, heat in a water bath at 50-60℃, and obtain solution A after it is fully dissolved;

[0049] Weigh the remaining butylene glycol in proportion, add the Corydalis root extract, heat to 110-120°C, and stir continuously to fully dissolve it to obtain Solution B;

[0050] When the temperature of liquid B drops to 90-95°C, add liquid A to liquid B and stir evenly to obtain liquid C; add 20.00% isosorbide dimethyl ether to the cooled liquid C, mix evenly, and process twice using a high-pressure microfluidizer to obtain CTR50.

[0051] (2) Add a thickener (0.20% carbomer and 0.40% sodium polyacrylate grafted starch) to 74.25% deionized water for soaking and dispersion, then add 0.15% methylparaben, heat to 80-90°C, homogenize at 2500 rpm for 5 minutes, stir and cool to obtain component A.

[0052] (3) When the temperature drops to 60-70°C, reduce the stirring speed and add the emulsifier (3.20% of cetearyl alcohol and 0.80% of sodium polyacrylate / ethylhexyl stearate / trideceth-6) in component B, 0.20% of menthyl lactate and 1.20% of menthol, and stir slowly to disperse evenly to obtain a mixed material.

[0053] (4) After the temperature of the mixed material has dropped to 50-60°C, 0.50% white willow bark extract, previously dissolved in 10% deionized water, is added, followed by 0.30% triethanolamine and 0.80% panthenol, and the mixture is stirred evenly. After the temperature has dropped to below 45°C, the materials in component D (0.40% phenoxyethanol, 0.60% menthone glycerol ketal, 5.00% CTR50, and 2.00% deionized water) are added, stirred evenly, and the analgesic ointment 1 is obtained.

[0054] Example 2

[0055] In this example, analgesic ointment 2 was prepared, which comprises the following components, calculated by weight:

[0056] Component A: Carbomer 0.20%, sodium polyacrylate grafted starch 0.40%, methylparaben 0.15%, deionized water 71.50%;

[0057] Component B: Cetearyl Alcohol 3.20%, Sodium Polyacrylate / Ethylhexyl Stearate / Trideceth-60.80%, Menthyl Lactate 0.20%, Menthol 1.20%;

[0058] Component C: triethanolamine 0.55%, panthenol 0.80%, white willow bark extract 0.50%, deionized water 10%;

[0059] Component D: phenoxyethanol 0.40%, menthone glyceryl ketal 0.60%, CTR50 7.50%, deionized water 2.00%.

[0060] The specific preparation process is the same as that in Example 1.

[0061] Example 3

[0062] In this example, an analgesic ointment 3 was prepared, which comprises, by percentage of each component to the total weight of the analgesic ointment:

[0063] Component A: Carbomer 0.20%, sodium polyacrylate grafted starch 0.40%, methylparaben 0.15%, deionized water 68.75%;

[0064] Component B: Cetearyl Alcohol 3.20%, Sodium Polyacrylate / Ethylhexyl Stearate / Trideceth-60.80%, Menthyl Lactate 0.20%, Menthol 1.20%;

[0065] Component C: triethanolamine 0.80%, panthenol 0.80%, white willow bark extract 0.50%, deionized water 10%;

[0066] Component D: phenoxyethanol 0.40%, menthone glyceryl ketal 0.60%, CTR501 0.00%, deionized water 2.00%.

[0067] The specific preparation process is the same as that in Example 1.

[0068] Example 4

[0069] In this example, an analgesic ointment 4 was prepared, which comprises, by percentage of each component to the total weight of the analgesic ointment:

[0070] Component A: Carbomer 0.20%, sodium polyacrylate grafted starch 0.40%, methylparaben 0.15%, deionized water 65.45%;

[0071] Component B: Cetearyl Alcohol 3.20%, Sodium Polyacrylate / Ethylhexyl Stearate / Trideceth-60.80%, Menthyl Lactate 0.20%, Menthol 1.20%;

[0072] Component C: triethanolamine 1.10%, panthenol 0.80%, white willow bark extract 0.50%, deionized water 10%;

[0073] Component D: phenoxyethanol 0.40%, menthone glyceryl ketal 0.60%, CTR501 3.00%, deionized water 2.00%.

[0074] The specific preparation process is the same as that in Example 1.

[0075] Test example

[0076] This test example tested the effect of the analgesic ointment prepared in Example.

[0077] 1. Evaluation of usage effect:

[0078] 40 subjects with joint strains and sprains, shoulder and neck discomfort, and lumbar muscle strain were screened and filled out questionnaires after using the analgesic ointments 1 to 4 prepared in Examples 1 to 4 for a period of time. The "onset time" and "duration time" of the analgesic ointments were evaluated and recorded. The specific results are shown in Table 1.

[0079] Table 1 Evaluation results of onset time and duration (n=40)

[0080]

[0081] As can be seen from Table 1, all four analgesic ointments have a faster onset and a longer duration, with Analgesic Ointment 4 > Analgesic Ointment 3 > Analgesic Ointment 2 > Analgesic Ointment 1. As can be seen from the formulas of Examples 1-4, Analgesic Ointment 1 includes 5.00% CTR50, Analgesic Ointment 2 includes 7.50% CTR50, Analgesic Ointment 3 includes 10.00% CTR50, and Analgesic Ointment 4 includes 13.00% CTR50. This indicates that the higher the CTR50 content, that is, the higher the content of Corydalis root extract, the faster the onset of the analgesic ointment, the longer the duration, and the better the pain relief effect. It also shows that due to the addition of Corydalis root extract through the CTR50 system, it can maintain a high content and can be stably present in the analgesic ointment to exert its analgesic effect.

[0082] 2. Evaluation of soothing and analgesic effects:

[0083] 40 subjects with joint strains and sprains, shoulder and neck discomfort, and lumbar muscle strain were screened respectively. After using the analgesic ointments 1 to 4 prepared in Examples 1 to 4, they filled out a questionnaire survey with reference to the standards in Table 2, and evaluated the three points of "relieving joint strains and sprains", "relieving shoulder and neck discomfort", and "relieving lumbar muscle strain". The specific results are shown in Tables 3, 4, and 5.

[0084] Table 2 Self-assessment scoring standards (7-level scoring method)

[0085]

[0086] Table 3 Evaluation results of analgesic ointment in relieving joint strains and sprains (n=40)

[0087]

[0088] Table 4 Evaluation results of analgesic ointment in relieving shoulder and neck discomfort (n=40)

[0089]

[0090] Table 5 Evaluation results of analgesic ointment in relieving lumbar muscle strain (n=40)

[0091]

[0092] Tables 3, 4, and 5 show that for the evaluation of the effects of "relieving joint strains and sprains", "relieving shoulder and neck discomfort", and "relieving lumbar muscle strain", all mean scores after using analgesic creams 1 to 4 were above 4.90. Statistically, more than 50% of the subjects gave positive comments on the soothing and analgesic effect scores of analgesic creams 1 to 4, among which analgesic creams 3 and 4 had better effects.

[0093] While the embodiments of the present invention have been described in detail above, the present invention is not limited to the embodiments described above. Various modifications may be made within the scope of knowledge possessed by a person skilled in the art without departing from the spirit of the present invention. Furthermore, the embodiments of the present invention and the features thereof may be combined with one another unless there is a conflict.

Claims

1. A pain-relieving ointment, characterized in that: Calculated by the percentage of each component in the total weight of the analgesic ointment: Component A: thickener 0.47-0.80%, methylparaben 0.13-0.18%, water 65.00-75.00%; Component B: emulsifier 3.40-4.80%, menthyl lactate 0.18-0.23%, menthol 1.00-1.20%; Component C: neutralizer 0.30-1.20%, panthenol 0.70-1.10%, white willow bark extract 0.50-1.30%, water 8.00-14.00%; Component D: phenoxyethanol 0.20-0.80%, menthone glyceryl ketal 0.50-0.80%, CTR50 5.00-13.00%, water 1.80-2.50%; Wherein, the CTR50 is: 2.00-10.00% of Corydalis yanhusuo root extract, 70.00-85.00% of butylene glycol, 0.50-4.00% of citric acid, and 5.00-25.00% of dimethyl isosorbide; Calculated by the percentage of each component in the total weight of the analgesic ointment, the thickener comprises: 0.17-0.25% of carbomer and 0.30-0.55% of sodium polyacrylate grafted starch.

2. The analgesic ointment according to claim 1, characterized in that Calculated by the percentage of each component in the total weight of the analgesic ointment, the emulsifier comprises: 2.80-3.80% of cetearyl alcohol, 0.60-1.00% of sodium polyacrylate / ethylhexyl stearate / trideceth-6.

3. The analgesic ointment according to claim 1, characterized in that The neutralizing agent is triethanolamine.

4. The method for preparing the analgesic ointment according to any one of claims 1 to 3, characterized in that: For the following steps: S1: Preparation of CTR50; S2: adding a thickener and methylparaben to water and mixing to prepare component A; S3: adding the emulsifier, menthyl lactate and menthol in component B to component A and mixing to obtain a mixed material; S4: adding the willow bark extract previously dissolved in water by heating to the mixture, then adding the neutralizer and panthenol in component C, and finally adding the phenoxyethanol, menthone glycerol ketal, CTR50 and water in component D, and mixing to obtain the analgesic ointment; The specific steps of preparing CTR50 are as follows: A1: Mix butanediol and citric acid in a mass ratio of (2-3):1 and dissolve to obtain Solution A; A2: Weigh the remaining butylene glycol in proportion, mix with the Corydalis yanhusuo root extract, and dissolve to obtain Solution B; A3: Add the liquid A to the liquid B and mix to obtain liquid C; add isosorbide dimethyl ether to the liquid C in proportion, mix, and then process using a high-pressure microfluidizer to obtain the CTR50.

5. The preparation method according to claim 4, characterized in that Step S2: first, add the thickener into the water to soak and disperse it, then add the methylparaben, heat to 80-90° C., homogenize at 2500-3000 r / min for 3-5 minutes, stir and cool to obtain the component A.

6. The preparation method according to claim 4, characterized in that In step S3, when the temperature of the component A drops to 60-70° C., the stirring speed is reduced, and the emulsifier, menthyl lactate and menthol in the component B are added and mixed to obtain the mixed material.

7. The preparation method according to claim 4, characterized in that In step S4, after the temperature of the mixed material drops to 50-60° C., the willow bark extract dissolved in water is added, and then the neutralizer and panthenol in component C are added.

8. The preparation method according to claim 7, characterized in that In step S4, after the temperature drops to below 45° C., phenoxyethanol, menthone glycerol ketal, CTR50 and water in the D component are added, mixed, and the analgesic ointment is obtained.

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